                         SEQUENCE LISTING

<110>  Scribe Therapeutics Inc.
 
<120>  ENGINEERED CASX SYSTEMS

<130>  SCRB-011/03WO 333322-2084

<150>  US 63/030,838
<151>  2020-05-27

<150>  US 62/944,892
<151>  2019-12-06

<150>  US 62/858,750
<151>  2019-06-07

<160>  4415  

<170>  PatentIn version 3.5

<210>  1
<211>  986
<212>  PRT
<213>  Unknown

<220>
<223>  Deltaproteobacteria sp.

<400>  1

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr 
            820                 825                 830         


Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly 
        835                 840                 845             


Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser 
865                 870                 875                 880 


Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser 
                885                 890                 895     


Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys 
        915                 920                 925             


Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  2
<211>  978
<212>  PRT
<213>  Unknown

<220>
<223>  Planctomycetes sp.

<400>  2

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3
<211>  855
<212>  PRT
<213>  Unknown

<220>
<223>  Candidatus Sungbacteria sp.

<400>  3

Met Asp Asn Ala Asn Lys Pro Ser Thr Lys Ser Leu Val Asn Thr Thr 
1               5                   10                  15      


Arg Ile Ser Asp His Phe Gly Val Thr Pro Gly Gln Val Thr Arg Val 
            20                  25                  30          


Phe Ser Phe Gly Ile Ile Pro Thr Lys Arg Gln Tyr Ala Ile Ile Glu 
        35                  40                  45              


Arg Trp Phe Ala Ala Val Glu Ala Ala Arg Glu Arg Leu Tyr Gly Met 
    50                  55                  60                  


Leu Tyr Ala His Phe Gln Glu Asn Pro Pro Ala Tyr Leu Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Tyr Glu Thr Phe Phe Lys Gly Arg Pro Val Leu Asn Gly Leu 
                85                  90                  95      


Arg Asp Ile Asp Pro Thr Ile Met Thr Ser Ala Val Phe Thr Ala Leu 
            100                 105                 110         


Arg His Lys Ala Glu Gly Ala Met Ala Ala Phe His Thr Asn His Arg 
        115                 120                 125             


Arg Leu Phe Glu Glu Ala Arg Lys Lys Met Arg Glu Tyr Ala Glu Cys 
    130                 135                 140                 


Leu Lys Ala Asn Glu Ala Leu Leu Arg Gly Ala Ala Asp Ile Asp Trp 
145                 150                 155                 160 


Asp Lys Ile Val Asn Ala Leu Arg Thr Arg Leu Asn Thr Cys Leu Ala 
                165                 170                 175     


Pro Glu Tyr Asp Ala Val Ile Ala Asp Phe Gly Ala Leu Cys Ala Phe 
            180                 185                 190         


Arg Ala Leu Ile Ala Glu Thr Asn Ala Leu Lys Gly Ala Tyr Asn His 
        195                 200                 205             


Ala Leu Asn Gln Met Leu Pro Ala Leu Val Lys Val Asp Glu Pro Glu 
    210                 215                 220                 


Glu Ala Glu Glu Ser Pro Arg Leu Arg Phe Phe Asn Gly Arg Ile Asn 
225                 230                 235                 240 


Asp Leu Pro Lys Phe Pro Val Ala Glu Arg Glu Thr Pro Pro Asp Thr 
                245                 250                 255     


Glu Thr Ile Ile Arg Gln Leu Glu Asp Met Ala Arg Val Ile Pro Asp 
            260                 265                 270         


Thr Ala Glu Ile Leu Gly Tyr Ile His Arg Ile Arg His Lys Ala Ala 
        275                 280                 285             


Arg Arg Lys Pro Gly Ser Ala Val Pro Leu Pro Gln Arg Val Ala Leu 
    290                 295                 300                 


Tyr Cys Ala Ile Arg Met Glu Arg Asn Pro Glu Glu Asp Pro Ser Thr 
305                 310                 315                 320 


Val Ala Gly His Phe Leu Gly Glu Ile Asp Arg Val Cys Glu Lys Arg 
                325                 330                 335     


Arg Gln Gly Leu Val Arg Thr Pro Phe Asp Ser Gln Ile Arg Ala Arg 
            340                 345                 350         


Tyr Met Asp Ile Ile Ser Phe Arg Ala Thr Leu Ala His Pro Asp Arg 
        355                 360                 365             


Trp Thr Glu Ile Gln Phe Leu Arg Ser Asn Ala Ala Ser Arg Arg Val 
    370                 375                 380                 


Arg Ala Glu Thr Ile Ser Ala Pro Phe Glu Gly Phe Ser Trp Thr Ser 
385                 390                 395                 400 


Asn Arg Thr Asn Pro Ala Pro Gln Tyr Gly Met Ala Leu Ala Lys Asp 
                405                 410                 415     


Ala Asn Ala Pro Ala Asp Ala Pro Glu Leu Cys Ile Cys Leu Ser Pro 
            420                 425                 430         


Ser Ser Ala Ala Phe Ser Val Arg Glu Lys Gly Gly Asp Leu Ile Tyr 
        435                 440                 445             


Met Arg Pro Thr Gly Gly Arg Arg Gly Lys Asp Asn Pro Gly Lys Glu 
    450                 455                 460                 


Ile Thr Trp Val Pro Gly Ser Phe Asp Glu Tyr Pro Ala Ser Gly Val 
465                 470                 475                 480 


Ala Leu Lys Leu Arg Leu Tyr Phe Gly Arg Ser Gln Ala Arg Arg Met 
                485                 490                 495     


Leu Thr Asn Lys Thr Trp Gly Leu Leu Ser Asp Asn Pro Arg Val Phe 
            500                 505                 510         


Ala Ala Asn Ala Glu Leu Val Gly Lys Lys Arg Asn Pro Gln Asp Arg 
        515                 520                 525             


Trp Lys Leu Phe Phe His Met Val Ile Ser Gly Pro Pro Pro Val Glu 
    530                 535                 540                 


Tyr Leu Asp Phe Ser Ser Asp Val Arg Ser Arg Ala Arg Thr Val Ile 
545                 550                 555                 560 


Gly Ile Asn Arg Gly Glu Val Asn Pro Leu Ala Tyr Ala Val Val Ser 
                565                 570                 575     


Val Glu Asp Gly Gln Val Leu Glu Glu Gly Leu Leu Gly Lys Lys Glu 
            580                 585                 590         


Tyr Ile Asp Gln Leu Ile Glu Thr Arg Arg Arg Ile Ser Glu Tyr Gln 
        595                 600                 605             


Ser Arg Glu Gln Thr Pro Pro Arg Asp Leu Arg Gln Arg Val Arg His 
    610                 615                 620                 


Leu Gln Asp Thr Val Leu Gly Ser Ala Arg Ala Lys Ile His Ser Leu 
625                 630                 635                 640 


Ile Ala Phe Trp Lys Gly Ile Leu Ala Ile Glu Arg Leu Asp Asp Gln 
                645                 650                 655     


Phe His Gly Arg Glu Gln Lys Ile Ile Pro Lys Lys Thr Tyr Leu Ala 
            660                 665                 670         


Asn Lys Thr Gly Phe Met Asn Ala Leu Ser Phe Ser Gly Ala Val Arg 
        675                 680                 685             


Val Asp Lys Lys Gly Asn Pro Trp Gly Gly Met Ile Glu Ile Tyr Pro 
    690                 695                 700                 


Gly Gly Ile Ser Arg Thr Cys Thr Gln Cys Gly Thr Val Trp Leu Ala 
705                 710                 715                 720 


Arg Arg Pro Lys Asn Pro Gly His Arg Asp Ala Met Val Val Ile Pro 
                725                 730                 735     


Asp Ile Val Asp Asp Ala Ala Ala Thr Gly Phe Asp Asn Val Asp Cys 
            740                 745                 750         


Asp Ala Gly Thr Val Asp Tyr Gly Glu Leu Phe Thr Leu Ser Arg Glu 
        755                 760                 765             


Trp Val Arg Leu Thr Pro Arg Tyr Ser Arg Val Met Arg Gly Thr Leu 
    770                 775                 780                 


Gly Asp Leu Glu Arg Ala Ile Arg Gln Gly Asp Asp Arg Lys Ser Arg 
785                 790                 795                 800 


Gln Met Leu Glu Leu Ala Leu Glu Pro Gln Pro Gln Trp Gly Gln Phe 
                805                 810                 815     


Phe Cys His Arg Cys Gly Phe Asn Gly Gln Ser Asp Val Leu Ala Ala 
            820                 825                 830         


Thr Asn Leu Ala Arg Arg Ala Ile Ser Leu Ile Arg Arg Leu Pro Asp 
        835                 840                 845             


Thr Asp Thr Pro Pro Thr Pro 
    850                 855 


<210>  4
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  4
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag agaaaccgau aaguaaaacg caucaaag                   108


<210>  5
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  5
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  6
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  6
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucggag a                                                 81


<210>  7
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  7
acaucuggcg cguuuauucc auuacuuugg agccaguccc agcgacuaug ucguauggac       60

gaagcgcuua uuuaucgg                                                     78


<210>  8
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  8
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga                                                   80


<210>  9
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  9
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgg                                                      77


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  10
guuuacacac ucccucucau agggu                                             25


<210>  11
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  11
guuuacacac ucccucucau gaggu                                             25


<210>  12
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  12
uuuuacauac ccccucucau gggau                                             25


<210>  13
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA sequence

<400>  13
guuuacacac ucccucucau ggggg                                             25


<210>  14
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  14
ccagcgacua ugucguaugg                                                   20


<210>  15
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  15
gcgcuuauuu aucggagaga aauccgauaa auaagaagc                              39


<210>  16
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  reference sgRNA

<400>  16
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cgga                                                         74


<210>  17
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgNA variant

<400>  17
attatctcat tact                                                         14


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  18
tccgagggga ccgtcccctc ggta                                              24


<210>  19
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  19
ggccggcatg gtcccagcct cctcgctggc gccggctggg aacat                       45


<210>  20
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  20
atggcgaatg ggaccc                                                       16


<210>  21
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  21
ttttggccgg catggtccca gcctcctcgc tggcgccggc tgggcaacat gcttcggcat       60

ggcgaatggg accccggg                                                     78


<210>  22
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gNA variant

<400>  22
cccggggtcc cattcgccat gccgaagcat gttgcccagc cggcgccagc gaggaggctg       60

ggaccatgcc ggccaaaa                                                     78


<210>  23
<211>  98
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sgNA variant

<400>  23
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttac ggacttcggt ccgtaagaag catcaaag                               98


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  24
gtgtagtaca agagatagaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  25
tgaagctgac agcattcggg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  26
tagatcgaga catgtaagca                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  27
ggccgagatg tctcgctccg                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  28
aggccagaaa gagagagtag                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  29
tgtggtcggg gtagcggctg                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  30
tcaagtccgc catgcccgaa                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  31
ccagggtgtc gccctcgaac                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  32
tgaccaccct gacctacggc                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  33
tggggcacaa gctggagtac                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  34
gtcgtgctgc ttcatgcaac                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  35
gtcgtgctgc tttgcatggt                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  36
gtcgtgctat cccatgtggt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  37
gtcgcatcgc ttcatgtggt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  38
actatgctgc ttcatgtggt                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  39
gtcgtgctgc ttcatacagt                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  40
gtcgtgctgc tttgcgtggt                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  41
gtcgtgctgt cccatgtggt                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  42
gtcgtgtcac ttcatgtggt                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  43
gtcacactgc ttcatgtggt                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  44
actgtgctgc ttcatgtggt                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  45
gtcgtgctgc ttcatgtgac                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  46
gtcgtgctgc ttcatgcagt                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  47
gtcgtgctgc ttcacatggt                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  48
gtcgtgctgc tttgtgtggt                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  49
gtcgtgctgc cccatgtggt                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  50
gtcgtgctat ttcatgtggt                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  51
gtcgtgtcgc ttcatgtggt                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  52
gtcgcactgc ttcatgtggt                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  53
gttatgctgc ttcatgtggt                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  54
accgtgctgc ttcatgtggt                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  55
gtcgtgctgc ttcatgtgat                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  56
gtcgtgctgc ttcatgcggt                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  57
gtcgtgctgc ttcacgtggt                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  58
gtcgtgctgc tttatgtggt                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  59
gtcgtgctgc ctcatgtggt                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  60
gtcgtgctac ttcatgtggt                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  61
gtcgtgttgc ttcatgtggt                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  62
gtcgcgctgc ttcatgtggt                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  63
gttgtgctgc ttcatgtggt                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  64
atcgtgctgc ttcatgtggt                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  65
gtcgtgctgc ttcatgtggt                                                   20


<210>  66
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  66
gaagtcgtgc tgcttcatgt aac                                               23


<210>  67
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  67
gaagtcgtgc tgcttcgcac ggt                                               23


<210>  68
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  68
gaagtcgtgc tgtcctatgt ggt                                               23


<210>  69
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  69
gaagtcgtat cacttcatgt ggt                                               23


<210>  70
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  70
gaagctacgc tgcttcatgt ggt                                               23


<210>  71
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  71
aggatcgtgc tgcttcatgt ggt                                               23


<210>  72
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  72
gaagtcgtgc tgcttcatgt gac                                               23


<210>  73
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  73
gaagtcgtgc tgcttcatac agt                                               23


<210>  74
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  74
gaagtcgtgc tgctttgcgt ggt                                               23


<210>  75
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  75
gaagtcgtgc tgtcccatgt ggt                                               23


<210>  76
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  76
gaagtcgtgt cacttcatgt ggt                                               23


<210>  77
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  77
gaagtcacac tgcttcatgt ggt                                               23


<210>  78
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  78
gaaactgtgc tgcttcatgt ggt                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  79
agggtcgtgc tgcttcatgt ggt                                               23


<210>  80
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  80
gaagtcgtgc tgcttcatgt aat                                               23


<210>  81
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  81
gaagtcgtgc tgcttcatac ggt                                               23


<210>  82
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  82
gaagtcgtgc tgcttcgcgt ggt                                               23


<210>  83
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  83
gaagtcgtgc tgctctatgt ggt                                               23


<210>  84
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  84
gaagtcgtgc tgtctcatgt ggt                                               23


<210>  85
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  85
gaagtcgtgc cacttcatgt ggt                                               23


<210>  86
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  86
gaagtcgtat tgcttcatgt ggt                                               23


<210>  87
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  87
gaagtcacgc tgcttcatgt ggt                                               23


<210>  88
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  88
gaagctgtgc tgcttcatgt ggt                                               23


<210>  89
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  89
gagatcgtgc tgcttcatgt ggt                                               23


<210>  90
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  90
agagtcgtgc tgcttcatgt ggt                                               23


<210>  91
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  91
gaagtcgtgc tgcttcatgt ggc                                               23


<210>  92
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  92
gaagtcgtgc tgcttcatgt agt                                               23


<210>  93
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  93
gaagtcgtgc tgcttcatat ggt                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  94
gaagtcgtgc tgcttcgtgt ggt                                               23


<210>  95
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  95
gaagtcgtgc tgctccatgt ggt                                               23


<210>  96
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  96
gaagtcgtgc tgtttcatgt ggt                                               23


<210>  97
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  97
gaagtcgtgc cgcttcatgt ggt                                               23


<210>  98
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  98
gaagtcgtac tgcttcatgt ggt                                               23


<210>  99
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  99
gaagtcatgc tgcttcatgt ggt                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  100
gaagccgtgc tgcttcatgt ggt                                               23


<210>  101
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  101
gaggtcgtgc tgcttcatgt ggt                                               23


<210>  102
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  102
aaagtcgtgc tgcttcatgt ggt                                               23


<210>  103
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  103
gaagtcgtgc tgcttcatgt ggt                                               23


<210>  104
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  104
agggcgacac cctggtaggt                                                   20


<210>  105
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  105
agggcgacac cccaacgaac                                                   20


<210>  106
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  106
agggcgacgt tttggtgaac                                                   20


<210>  107
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  107
agggtagtac cctggtgaac                                                   20


<210>  108
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  108
gaaacgacac cctggtgaac                                                   20


<210>  109
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  109
agggcgacac cctggcagac                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  110
agggcgacac cccaatgaac                                                   20


<210>  111
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  111
agggcgacat tttggtgaac                                                   20


<210>  112
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  112
agggcggtgc cctggtgaac                                                   20


<210>  113
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  113
aggataacac cctggtgaac                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  114
gaagcgacac cctggtgaac                                                   20


<210>  115
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  115
agggcgacac cctggtgagt                                                   20


<210>  116
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  116
agggcgacac cctggtagac                                                   20


<210>  117
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  117
agggcgacac cctgacgaac                                                   20


<210>  118
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  118
agggcgacac cccagtgaac                                                   20


<210>  119
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  119
agggcgacac tttggtgaac                                                   20


<210>  120
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  120
agggcgacgt cctggtgaac                                                   20


<210>  121
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  121
agggcggtac cctggtgaac                                                   20


<210>  122
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  122
agggtaacac cctggtgaac                                                   20


<210>  123
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  123
agaacgacac cctggtgaac                                                   20


<210>  124
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  124
gaggcgacac cctggtgaac                                                   20


<210>  125
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  125
agggcgacac cctggtgagc                                                   20


<210>  126
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  126
agggcgacac cctggtaaac                                                   20


<210>  127
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  127
agggcgacac cctgatgaac                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  128
agggcgacac cccggtgaac                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  129
agggcgacac tctggtgaac                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  130
agggcgacgc cctggtgaac                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  131
agggcggcac cctggtgaac                                                   20


<210>  132
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  132
agggtgacac cctggtgaac                                                   20


<210>  133
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  133
agagcgacac cctggtgaac                                                   20


<210>  134
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  134
ggggcgacac cctggtgaac                                                   20


<210>  135
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  135
agggcgacac cctggtgaac                                                   20


<210>  136
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  136
gaagttcgag ggtagtaccc                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  137
gaagttcgga aacgacaccc                                                   20


<210>  138
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  138
gaagcctaag ggcgacaccc                                                   20


<210>  139
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  139
aggattcgag ggcgacaccc                                                   20


<210>  140
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  140
gaagttcgag ggcgatgtcc                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  141
gaagttcgag ggtagcaccc                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  142
gaagttcgaa aacgacaccc                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  143
gaagtttagg ggcgacaccc                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  144
gaaacccgag ggcgacaccc                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  145
agggttcgag ggcgacaccc                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  146
gaagttcgag ggcgacactt                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  147
gaagttcgag ggcgacgtcc                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  148
gaagttcgag ggcggtaccc                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  149
gaagttcgag ggtaacaccc                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  150
gaagttcgag aacgacaccc                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  151
gaagttcgga ggcgacaccc                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  152
gaagtttaag ggcgacaccc                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  153
gaagcccgag ggcgacaccc                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  154
gagattcgag ggcgacaccc                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  155
agagttcgag ggcgacaccc                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  156
gaagttcgag ggcgacactc                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  157
gaagttcgag ggcgacgccc                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  158
gaagttcgag ggcggcaccc                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  159
gaagttcgag ggtgacaccc                                                   20


<210>  160
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  160
gaagttcgag agcgacaccc                                                   20


<210>  161
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  161
gaagttcggg ggcgacaccc                                                   20


<210>  162
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  162
gaagtttgag ggcgacaccc                                                   20


<210>  163
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  163
gaagctcgag ggcgacaccc                                                   20


<210>  164
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  164
gaggttcgag ggcgacaccc                                                   20


<210>  165
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  165
aaagttcgag ggcgacaccc                                                   20


<210>  166
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  166
gaagttcgag ggcgacaccc                                                   20


<210>  167
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  167
tcgccctcga acttcacctc aat                                               23


<210>  168
<211>  24
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  168
tcgccctcga acttcattcc tggc                                              24


<210>  169
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  169
tcgccctcga accctgcctc ggc                                               23


<210>  170
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  170
tcgccctcag gtttcacctc ggc                                               23


<210>  171
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  171
tcgcttctga acttcacctc ggc                                               23


<210>  172
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  172
ctatcctcga acttcacctc ggc                                               23


<210>  173
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  173
tcgccctcga acttcacctc gat                                               23


<210>  174
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  174
tcgccctcga acttcaccct agc                                               23


<210>  175
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  175
tcgccctcga acttcgtttc ggc                                               23


<210>  176
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  176
tcgccctcga accctacctc ggc                                               23


<210>  177
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  177
tcgccctcgg gtttcacctc ggc                                               23


<210>  178
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  178
tcgcccctaa acttcacctc ggc                                               23


<210>  179
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  179
tcgttttcga acttcacctc ggc                                               23


<210>  180
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  180
ctaccctcga acttcacctc ggc                                               23


<210>  181
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  181
tcgccctcga acttcacctc aac                                               23


<210>  182
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  182
tcgccctcga acttcaccct ggc                                               23


<210>  183
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  183
tcgccctcga acttcatttc ggc                                               23


<210>  184
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  184
tcgccctcga actttgcctc ggc                                               23


<210>  185
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  185
tcgccctcga accccacctc ggc                                               23


<210>  186
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  186
tcgccctcga gtttcacctc ggc                                               23


<210>  187
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  187
tcgccctcag acttcacctc ggc                                               23


<210>  188
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  188
tcgcccctga acttcacctc ggc                                               23


<210>  189
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  189
tcgctttcga acttcacctc ggc                                               23


<210>  190
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  190
tcatcctcga acttcacctc ggc                                               23


<210>  191
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  191
ctgccctcga acttcacctc ggc                                               23


<210>  192
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  192
tcgccctcga acttcacctc ggt                                               23


<210>  193
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  193
tcgccctcga acttcacctc agc                                               23


<210>  194
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  194
tcgccctcga acttcacccc ggc                                               23


<210>  195
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  195
tcgccctcga acttcatctc ggc                                               23


<210>  196
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  196
tcgccctcga actttacctc ggc                                               23


<210>  197
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  197
tcgccctcga acctcacctc ggc                                               23


<210>  198
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  198
tcgccctcga gcttcacctc ggc                                               23


<210>  199
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  199
tcgccctcaa acttcacctc ggc                                               23


<210>  200
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  200
tcgcccccga acttcacctc ggc                                               23


<210>  201
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  201
tcgctctcga acttcacctc ggc                                               23


<210>  202
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  202
tcaccctcga acttcacctc ggc                                               23


<210>  203
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  203
ccgccctcga acttcacctc ggc                                               23


<210>  204
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  204
tcgccctcga acttcacctc ggc                                               23


<210>  205
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  205
tgtggtcggg gtagcgatca                                                   20


<210>  206
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  206
tgtggtcggg gtgatagctg                                                   20


<210>  207
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  207
tgtggtcgaa acagcggctg                                                   20


<210>  208
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  208
tgtgactagg gtagcggctg                                                   20


<210>  209
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  209
cacagtcggg gtagcggctg                                                   20


<210>  210
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  210
tgtggtcggg gtagcaattg                                                   20


<210>  211
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  211
tgtggtcggg gtgatggctg                                                   20


<210>  212
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  212
tgtggtcgga acagcggctg                                                   20


<210>  213
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  213
tgtggttaag gtagcggctg                                                   20


<210>  214
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  214
tgtaaccggg gtagcggctg                                                   20


<210>  215
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  215
cacggtcggg gtagcggctg                                                   20


<210>  216
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  216
tgtggtcggg gtagcggcca                                                   20


<210>  217
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  217
tgtggtcggg gtagcgattg                                                   20


<210>  218
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  218
tgtggtcggg gtagtagctg                                                   20


<210>  219
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  219
tgtggtcggg gtgacggctg                                                   20


<210>  220
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  220
tgtggtcggg acagcggctg                                                   20


<210>  221
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  221
tgtggtcgaa gtagcggctg                                                   20


<210>  222
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  222
tgtggttagg gtagcggctg                                                   20


<210>  223
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  223
tgtgaccggg gtagcggctg                                                   20


<210>  224
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  224
tgcagtcggg gtagcggctg                                                   20


<210>  225
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  225
catggtcggg gtagcggctg                                                   20


<210>  226
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  226
tgtggtcggg gtagcggccg                                                   20


<210>  227
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  227
tgtggtcggg gtagcgactg                                                   20


<210>  228
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  228
tgtggtcggg gtagtggctg                                                   20


<210>  229
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  229
tgtggtcggg gtggcggctg                                                   20


<210>  230
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  230
tgtggtcggg atagcggctg                                                   20


<210>  231
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  231
tgtggtcgag gtagcggctg                                                   20


<210>  232
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  232
tgtggttggg gtagcggctg                                                   20


<210>  233
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  233
tgtgatcggg gtagcggctg                                                   20


<210>  234
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  234
tgcggtcggg gtagcggctg                                                   20


<210>  235
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  235
cgtggtcggg gtagcggctg                                                   20


<210>  236
<211>  20
<212>  DNA
<213>  Unknown

<220>
<223>  spacer sequence

<400>  236
tgtggtcggg gtagcggctg                                                   20


<210>  237
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  scaffold stem loop of an exemplary reference sgRNA

<400>  237
ccaucaccag cgacuauguc guaugg                                            26


<210>  238
<211>  46
<212>  RNA
<213>  Unknown

<220>
<223>  extended stem loop sequence of an exemplary reference sgRNA

<400>  238
guaaacgcuu auuuaucgga gagaaauccg auaaauaaga agcauc                      46


<210>  239
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SOD1 targeting spacer 2

<400>  239
atgttcatga gtttggagat                                                   20


<210>  240
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(28)
<223>  These individual nucleotides may be absent

<400>  240
uuunnnnnnn nnnnnnnnnn nnnnnnnnuu u                                      31


<210>  241
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(28)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (8)..(18)
<223>  These individual nucleotides may be absent

<400>  241
uuunnnnnnn nnnnnnnnuu u                                                 21


<210>  242
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  scaffold stem loop sequence of a gNA

<400>  242
ccagcgacua ugucguaugg                                                   20


<210>  243
<211>  23
<212>  RNA
<213>  Unknown

<220>
<223>  crRNA sequence

<400>  243
ccgauaagua aaacgcauca aag                                               23


<210>  244
<211>  26
<212>  RNA
<213>  Unknown

<220>
<223>  crRNA sequence

<400>  244
ucuccgauaa auaagaagca ucaaag                                            26


<210>  245
<211>  21
<212>  RNA
<213>  Unknown

<220>
<223>  scaffold stem loop

<400>  245
ccagcgacua ugucguagug g                                                 21


<210>  246
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  zinc finger/ribbon domain


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  246

Cys Xaa Xaa Cys 
1               


<210>  247
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  247

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys 
            100                 105                 110         


Leu Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu 
                165                 170                 175     


Lys Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  248
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  248

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Thr Ala Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser 
            820                 825                 830         


Asp Gly Trp Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu 
    850                 855                 860                 


Leu Ser Ala Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Lys Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu 
            900                 905                 910         


Asp Cys Gly His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  249
<211>  985
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  249

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys 
        195                 200                 205             


Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn 
                245                 250                 255     


Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu 
            260                 265                 270         


Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro 
305                 310                 315                 320 


Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg Arg 
                325                 330                 335     


Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys Leu 
            340                 345                 350         


Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val Thr 
        355                 360                 365             


Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro Asn 
    370                 375                 380                 


Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys Lys 
385                 390                 395                 400 


Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys Lys 
                405                 410                 415     


Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg Ile 
            420                 425                 430         


Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu Ala 
        435                 440                 445             


Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp Leu 
    450                 455                 460                 


Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp Glu 
465                 470                 475                 480 


Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly Asp 
                485                 490                 495     


Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val Asp 
            500                 505                 510         


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
        515                 520                 525             


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
    530                 535                 540                 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
545                 550                 555                 560 


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
                565                 570                 575     


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
            580                 585                 590         


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
        595                 600                 605             


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
    610                 615                 620                 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
625                 630                 635                 640 


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
                645                 650                 655     


Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp Arg 
            660                 665                 670         


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
        675                 680                 685             


Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile Leu 
    690                 695                 700                 


Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala Ala 
705                 710                 715                 720 


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe Ala 
                725                 730                 735     


Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala Arg 
            740                 745                 750         


Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe Glu 
        755                 760                 765             


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Thr 
    770                 775                 780                 


Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
785                 790                 795                 800 


Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln 
                805                 810                 815     


Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Thr Ala 
            820                 825                 830         


Asp Tyr Asp Gly Met Leu Val Arg Leu Lys Lys Thr Ser Asp Gly Trp 
        835                 840                 845             


Ala Thr Thr Leu Asn Asn Lys Glu Leu Lys Ala Glu Gly Gln Ile Thr 
    850                 855                 860                 


Tyr Tyr Asn Arg Tyr Lys Arg Gln Thr Val Glu Lys Glu Leu Ser Ala 
865                 870                 875                 880 


Glu Leu Asp Arg Leu Ser Glu Glu Ser Gly Asn Asn Asp Ile Ser Lys 
                885                 890                 895     


Trp Thr Lys Gly Arg Arg Asp Glu Ala Leu Phe Leu Leu Lys Lys Arg 
            900                 905                 910         


Phe Ser His Arg Pro Val Gln Glu Gln Phe Val Cys Leu Asp Cys Gly 
        915                 920                 925             


His Glu Val His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser 
    930                 935                 940                 


Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys Ser 
945                 950                 955                 960 


Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg Arg 
                965                 970                 975     


Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985 


<210>  250
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  250

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Asn Ala Ala Asn Asn 
    50                  55                  60                  


Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala Ile Leu 
65                  70                  75                  80  


Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu Met Cys 
                85                  90                  95      


Lys Phe Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys 
            100                 105                 110         


Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser 
    130                 135                 140                 


Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala 
145                 150                 155                 160 


Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp 
                165                 170                 175     


Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu Arg 
                325                 330                 335     


Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys Lys 
            340                 345                 350         


Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly Val 
        355                 360                 365             


Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu Pro 
    370                 375                 380                 


Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro Lys 
385                 390                 395                 400 


Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu Lys 
                405                 410                 415     


Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu Arg 
            420                 425                 430         


Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu Glu 
        435                 440                 445             


Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp Trp 
    450                 455                 460                 


Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met Asp 
465                 470                 475                 480 


Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr Gly 
                485                 490                 495     


Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Arg Val Val 
            500                 505                 510         


Asp Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr 
        515                 520                 525             


Arg Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe 
    530                 535                 540                 


Tyr Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp 
545                 550                 555                 560 


Gly Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly 
                565                 570                 575     


Gly Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu 
            580                 585                 590         


Gln Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu 
        595                 600                 605             


Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu 
    610                 615                 620                 


Ala Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly 
625                 630                 635                 640 


Arg Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu 
                645                 650                 655     


Val Val Asp Pro Ser Asn Ile Lys Pro Val Asn Leu Ile Gly Val Asp 
            660                 665                 670         


Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly 
        675                 680                 685             


Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro Thr Asp Ile 
    690                 695                 700                 


Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala Ile Gln Ala 
705                 710                 715                 720 


Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Phe 
                725                 730                 735     


Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg Asn Ser Ala 
            740                 745                 750         


Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val Leu Val Phe 
        755                 760                 765             


Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met 
    770                 775                 780                 


Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr Ala Lys Leu 
785                 790                 795                 800 


Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
                805                 810                 815     


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
            820                 825                 830         


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
        835                 840                 845             


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
    850                 855                 860                 


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
865                 870                 875                 880 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
                885                 890                 895     


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
            900                 905                 910         


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
        915                 920                 925             


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
    930                 935                 940                 


Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser Tyr Lys 
945                 950                 955                 960 


Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr Lys Arg 
                965                 970                 975     


Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
            980                 985     


<210>  251
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  251

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala 
        915                 920     


<210>  252
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  252

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala 
        915                 920 


<210>  253
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  253

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Asn Ala Ala 
    50                  55                  60                  


Asn Asn Leu Arg Met Leu Leu Asp Asp Tyr Thr Lys Met Lys Glu Ala 
65                  70                  75                  80  


Ile Leu Gln Val Tyr Trp Gln Glu Phe Lys Asp Asp His Val Gly Leu 
                85                  90                  95      


Met Cys Lys Phe Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  254
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  254

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  255
<211>  925
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  255

Met Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp 
1               5                   10                  15      


Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe 
            20                  25                  30          


Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro 
        35                  40                  45              


Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu 
    50                  55                  60                  


Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu 
65                  70                  75                  80  


Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr 
                85                  90                  95      


Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu 
            100                 105                 110         


Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser 
        115                 120                 125             


Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val 
    130                 135                 140                 


Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly 
145                 150                 155                 160 


Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys 
                165                 170                 175     


Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu 
            180                 185                 190         


Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu 
        195                 200                 205             


Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu 
    210                 215                 220                 


Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val 
225                 230                 235                 240 


Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu 
                245                 250                 255     


Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe 
            260                 265                 270         


Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp 
        275                 280                 285             


Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp 
    290                 295                 300                 


Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala 
305                 310                 315                 320 


Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys 
                325                 330                 335     


Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys 
            340                 345                 350         


His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile 
        355                 360                 365             


Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu 
    370                 375                 380                 


Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu 
385                 390                 395                 400 


Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys 
                405                 410                 415     


Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp 
            420                 425                 430         


Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Arg Val Val Asp 
        435                 440                 445             


Ile Ser Gly Phe Ser Ile Gly Ser Asp Gly His Ser Ile Gln Tyr Arg 
    450                 455                 460                 


Asn Leu Leu Ala Trp Lys Tyr Leu Glu Asn Gly Lys Arg Glu Phe Tyr 
465                 470                 475                 480 


Leu Leu Met Asn Tyr Gly Lys Lys Gly Arg Ile Arg Phe Thr Asp Gly 
                485                 490                 495     


Thr Asp Ile Lys Lys Ser Gly Lys Trp Gln Gly Leu Leu Tyr Gly Gly 
            500                 505                 510         


Gly Lys Ala Lys Val Ile Asp Leu Thr Phe Asp Pro Asp Asp Glu Gln 
        515                 520                 525             


Leu Ile Ile Leu Pro Leu Ala Phe Gly Thr Arg Gln Gly Arg Glu Phe 
    530                 535                 540                 


Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Leu Ile Lys Leu Ala 
545                 550                 555                 560 


Asn Gly Arg Val Ile Glu Lys Thr Ile Tyr Asn Lys Lys Ile Gly Arg 
                565                 570                 575     


Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val 
            580                 585                 590         


Val Asp Pro Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg 
        595                 600                 605             


Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys 
    610                 615                 620                 


Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu 
625                 630                 635                 640 


Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys 
                645                 650                 655     


Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala 
            660                 665                 670         


Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg 
        675                 680                 685             


Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu 
    690                 695                 700                 


Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala 
705                 710                 715                 720 


Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala 
                725                 730                 735     


Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr 
            740                 745                 750         


Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp 
        755                 760                 765             


Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met 
    770                 775                 780                 


Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr 
785                 790                 795                 800 


Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu 
                805                 810                 815     


Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp 
            820                 825                 830         


Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe 
        835                 840                 845             


Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe 
    850                 855                 860                 


Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp 
865                 870                 875                 880 


Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr 
                885                 890                 895     


Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe 
            900                 905                 910         


Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
        915                 920                 925 


<210>  256
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  256

Met Glu Lys Arg Ile Asn Lys Ile Arg Lys Lys Leu Ser Ala Asp Asn 
1               5                   10                  15      


Ala Thr Lys Pro Val Ser Arg Ser Gly Pro Met Lys Thr Leu Leu Val 
            20                  25                  30          


Arg Val Met Thr Asp Asp Leu Lys Lys Arg Leu Glu Lys Arg Arg Lys 
        35                  40                  45              


Lys Pro Glu Val Met Pro Gln Val Ile Ser Asn Thr Ser Arg Ala Asn 
    50                  55                  60                  


Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu 
65                  70                  75                  80  


His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser 
                85                  90                  95      


Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile 
            100                 105                 110         


Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys 
        115                 120                 125             


Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn 
    130                 135                 140                 


Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser 
145                 150                 155                 160 


Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn 
                165                 170                 175     


Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu 
            180                 185                 190         


Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys 
        195                 200                 205             


Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly 
    210                 215                 220                 


Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr 
225                 230                 235                 240 


Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn 
                245                 250                 255     


Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu 
            260                 265                 270         


Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly 
        275                 280                 285             


Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn 
    290                 295                 300                 


Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro 
305                 310                 315                 320 


Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln 
                325                 330                 335     


Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu 
            340                 345                 350         


Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala 
        355                 360                 365             


Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu 
    370                 375                 380                 


Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu 
385                 390                 395                 400 


Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr 
                405                 410                 415     


Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys 
            420                 425                 430         


His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys 
        435                 440                 445             


Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu 
    450                 455                 460                 


Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys 
465                 470                 475                 480 


Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu 
                485                 490                 495     


Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn 
            500                 505                 510         


Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr 
        515                 520                 525             


Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile 
    530                 535                 540                 


Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys 
545                 550                 555                 560 


Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp 
                565                 570                 575     


Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg 
            580                 585                 590         


Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys 
        595                 600                 605             


Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr 
    610                 615                 620                 


Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg 
625                 630                 635                 640 


Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile 
                645                 650                 655     


Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu 
            660                 665                 670         


Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His 
        675                 680                 685             


Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln 
    690                 695                 700                 


Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys 
705                 710                 715                 720 


Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr 
                725                 730                 735     


Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile 
            740                 745                 750         


Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe 
        755                 760                 765             


Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys 
    770                 775                 780                 


Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala 
785                 790                 795                 800 


Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser 
                805                 810                 815     


Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly 
            820                 825                 830         


Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile 
        835                 840                 845             


Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser 
    850                 855                 860                 


Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser 
865                 870                 875                 880 


Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys 
                885                 890                 895     


Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys 
            900                 905                 910         


Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg 
        915                 920                 925             


Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn 
    930                 935                 940                 


Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln 
945                 950                 955                 960 


Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975 


<210>  257
<211>  982
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  257

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Arg Val Val Asp Ile Ser Gly Phe Ser Ile Gly 
            500                 505                 510         


Ser Asp Gly His Ser Ile Gln Tyr Arg Asn Leu Leu Ala Trp Lys Tyr 
        515                 520                 525             


Leu Glu Asn Gly Lys Arg Glu Phe Tyr Leu Leu Met Asn Tyr Gly Lys 
    530                 535                 540                 


Lys Gly Arg Ile Arg Phe Thr Asp Gly Thr Asp Ile Lys Lys Ser Gly 
545                 550                 555                 560 


Lys Trp Gln Gly Leu Leu Tyr Gly Gly Gly Lys Ala Lys Val Ile Asp 
                565                 570                 575     


Leu Thr Phe Asp Pro Asp Asp Glu Gln Leu Ile Ile Leu Pro Leu Ala 
            580                 585                 590         


Phe Gly Thr Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Gly Leu Ile Lys Leu Ala Asn Gly Arg Val Ile Glu Lys 
    610                 615                 620                 


Thr Ile Tyr Asn Lys Lys Ile Gly Arg Asp Glu Pro Ala Leu Phe Val 
625                 630                 635                 640 


Ala Leu Thr Phe Glu Arg Arg Glu Val Val Asp Pro Ser Asn Ile Lys 
                645                 650                 655     


Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val 
            660                 665                 670         


Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp 
        675                 680                 685             


Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys 
    690                 695                 700                 


Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg 
705                 710                 715                 720 


Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala 
                725                 730                 735     


Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val 
            740                 745                 750         


Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly 
        755                 760                 765             


Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met 
    770                 775                 780                 


Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr 
785                 790                 795                 800 


Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn 
                805                 810                 815     


Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys 
            820                 825                 830         


Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu 
        835                 840                 845             


Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln 
    850                 855                 860                 


Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu 
865                 870                 875                 880 


Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu 
                885                 890                 895     


Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu 
            900                 905                 910         


Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln 
        915                 920                 925             


Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu 
    930                 935                 940                 


Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg 
945                 950                 955                 960 


Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu 
                965                 970                 975     


Val Trp Lys Pro Ala Val 
            980         


<210>  258
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  258

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  259
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  259

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala 
    


<210>  260
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  260

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  261
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  261

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  262
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  262

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  263
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  263

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  264
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  264

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  265
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  265

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  266
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  266

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  267
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  267

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  268
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  268

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  269
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  269

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  270
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  270

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  271
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  271

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  272
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  272

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  273
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  273

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  274
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  274

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  275
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  275

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  276
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  276

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  277
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  277

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  278
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  278

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  279
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  279

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  280
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  280

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  281
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  281

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  282
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  282

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  283
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  283

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  284
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  284

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  285
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  285

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  286
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  286

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  287
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  287

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Val 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  288
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  288

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  289
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  289

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  290
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  290

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  291
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  291

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  292
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  292

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  293
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  293

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  294
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  294

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  295
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  295

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  296
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  296

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  297
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  297

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  298
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  298

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  299
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  299

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  300
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  300

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Ser Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  301
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  301

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  302
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  302

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  303
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  303

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  304
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  304

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  305
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  305

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  306
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  306

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  307
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  307

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  308
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  308

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  309
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  309

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  310
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  310

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  311
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  311

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  312
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  312

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  313
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  313

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  314
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  314

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  315
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  315

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  316
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  316

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  317
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  317

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  318
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  318

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  319
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  319

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  320
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  320

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  321
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  321

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  322
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  322

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  323
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  323

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  324
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  324

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  325
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  325

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  326
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  326

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  327
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  327

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  328
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  328

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  329
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  329

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  330
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  330

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  331
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  331

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  332
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  332

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val 
        195                 200                 205             


Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu 
225                 230                 235                 240 


Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly 
                245                 250                 255     


Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn 
            260                 265                 270         


Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys 
305                 310                 315                 320 


Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  333
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  333

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  334
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  334

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  335
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  335

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  336
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  336

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Lys Glu Ser Thr His Pro 
        195                 200                 205             


Val Lys Pro Leu Ala Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe 
225                 230                 235                 240 


Leu Ser Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Val Lys 
                245                 250                 255     


Gly Asn Gln Lys Arg Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu 
            260                 265                 270         


Asn Leu Glu Tyr Pro Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Val Asp Ala Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala 
305                 310                 315                 320 


Lys Pro Leu Leu Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  337
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  337

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu 
            100                 105                 110         


Lys Pro Glu Met Asp Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Gly Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Ser Glu Lys Gly Lys Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ala Glu His Glu Lys Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys 
                165                 170                 175     


Asp Ser Asp Glu Ala Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  338
<211>  84
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  338

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Cys Met Gln Val Trp Pro Pro Ile 
    50                  55                  60                  


Gly Lys Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Pro Leu Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Ala 
                


<210>  339
<211>  57
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  339

Met Ala Ser Met Ile Ser Ser Ser Ala Val Thr Thr Val Ser Arg Ala 
1               5                   10                  15      


Ser Arg Gly Gln Ser Ala Ala Met Ala Pro Phe Gly Gly Leu Lys Ser 
            20                  25                  30          


Met Thr Gly Phe Pro Val Arg Lys Val Asn Thr Asp Ile Thr Ser Ile 
        35                  40                  45              


Thr Ser Asn Gly Gly Arg Val Lys Ser 
    50                  55          


<210>  340
<211>  85
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  340

Met Ala Ser Ser Met Leu Ser Ser Ala Thr Met Val Ala Ser Pro Ala 
1               5                   10                  15      


Gln Ala Thr Met Val Ala Pro Phe Asn Gly Leu Lys Ser Ser Ala Ala 
            20                  25                  30          


Phe Pro Ala Thr Arg Lys Ala Asn Asn Asp Ile Thr Ser Ile Thr Ser 
        35                  40                  45              


Asn Gly Gly Arg Val Asn Cys Met Gln Val Trp Pro Pro Ile Glu Lys 
    50                  55                  60                  


Lys Lys Phe Glu Thr Leu Ser Tyr Leu Pro Asp Leu Thr Asp Ser Gly 
65                  70                  75                  80  


Gly Arg Val Asn Cys 
                85  


<210>  341
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  341

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Gln Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  342
<211>  76
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  342

Met Ala Gln Val Ser Arg Ile Cys Asn Gly Val Trp Asn Pro Ser Leu 
1               5                   10                  15      


Ile Ser Asn Leu Ser Lys Ser Ser Gln Arg Lys Ser Pro Leu Ser Val 
            20                  25                  30          


Ser Leu Lys Thr Gln Gln His Pro Arg Ala Tyr Pro Ile Ser Ser Ser 
        35                  40                  45              


Trp Gly Leu Lys Lys Ser Gly Met Thr Leu Ile Gly Ser Glu Leu Arg 
    50                  55                  60                  


Pro Leu Lys Val Met Ser Ser Val Ser Thr Ala Cys 
65                  70                  75      


<210>  343
<211>  72
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  343

Met Ala Gln Ile Asn Asn Met Ala Gln Gly Ile Gln Thr Leu Asn Pro 
1               5                   10                  15      


Asn Ser Asn Phe His Lys Pro Gln Val Pro Lys Ser Ser Ser Phe Leu 
            20                  25                  30          


Val Phe Gly Ser Lys Lys Leu Lys Asn Ser Ala Asn Ser Met Leu Val 
        35                  40                  45              


Leu Lys Lys Asp Ser Ile Phe Met Gln Leu Phe Cys Ser Phe Arg Ile 
    50                  55                  60                  


Ser Ala Ser Val Ala Thr Ala Cys 
65                  70          


<210>  344
<211>  69
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  344

Met Ala Ala Leu Val Thr Ser Gln Leu Ala Thr Ser Gly Thr Val Leu 
1               5                   10                  15      


Ser Val Thr Asp Arg Phe Arg Arg Pro Gly Phe Gln Gly Leu Arg Pro 
            20                  25                  30          


Arg Asn Pro Ala Asp Ala Ala Leu Gly Met Arg Thr Val Gly Ala Ser 
        35                  40                  45              


Ala Ala Pro Lys Gln Ser Arg Lys Pro His Arg Phe Asp Arg Arg Cys 
    50                  55                  60                  


Leu Ser Met Val Val 
65                  


<210>  345
<211>  77
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  345

Met Ala Ala Leu Thr Thr Ser Gln Leu Ala Thr Ser Ala Thr Gly Phe 
1               5                   10                  15      


Gly Ile Ala Asp Arg Ser Ala Pro Ser Ser Leu Leu Arg His Gly Phe 
            20                  25                  30          


Gln Gly Leu Lys Pro Arg Ser Pro Ala Gly Gly Asp Ala Thr Ser Leu 
        35                  40                  45              


Ser Val Thr Thr Ser Ala Arg Ala Thr Pro Lys Gln Gln Arg Ser Val 
    50                  55                  60                  


Gln Arg Gly Ser Arg Arg Phe Pro Ser Val Val Val Cys 
65                  70                  75          


<210>  346
<211>  57
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  346

Met Ala Ser Ser Val Leu Ser Ser Ala Ala Val Ala Thr Arg Ser Asn 
1               5                   10                  15      


Val Ala Gln Ala Asn Met Val Ala Pro Phe Thr Gly Leu Lys Ser Ala 
            20                  25                  30          


Ala Ser Phe Pro Val Ser Arg Lys Gln Asn Leu Asp Ile Thr Ser Ile 
        35                  40                  45              


Ala Ser Asn Gly Gly Arg Val Gln Cys 
    50                  55          


<210>  347
<211>  65
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  347

Met Glu Ser Leu Ala Ala Thr Ser Val Phe Ala Pro Ser Arg Val Ala 
1               5                   10                  15      


Val Pro Ala Ala Arg Ala Leu Val Arg Ala Gly Thr Val Val Pro Thr 
            20                  25                  30          


Arg Arg Thr Ser Ser Thr Ser Gly Thr Ser Gly Val Lys Cys Ser Ala 
        35                  40                  45              


Ala Val Thr Pro Gln Ala Ser Pro Val Ile Ser Arg Ser Ala Ala Ala 
    50                  55                  60                  


Ala 
65  


<210>  348
<211>  72
<212>  PRT
<213>  Unknown

<220>
<223>  chloroplast transit peptide

<400>  348

Met Gly Ala Ala Ala Thr Ser Met Gln Ser Leu Lys Phe Ser Asn Arg 
1               5                   10                  15      


Leu Val Pro Pro Ser Arg Arg Leu Ser Pro Val Pro Asn Asn Val Thr 
            20                  25                  30          


Cys Asn Asn Leu Pro Lys Ser Ala Ala Pro Val Arg Thr Val Lys Cys 
        35                  40                  45              


Cys Ala Ser Ser Trp Asn Ser Thr Ile Asn Gly Ala Ala Ala Thr Thr 
    50                  55                  60                  


Asn Gly Ala Ser Ala Ala Ser Ser 
65                  70          


<210>  349
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  endosomal escape peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys, His or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, His or Arg

<400>  349

Gly Leu Phe Xaa Ala Leu Leu Xaa Leu Leu Xaa Ser Leu Trp Xaa Leu 
1               5                   10                  15      


Leu Leu Xaa Ala 
            20  


<210>  350
<211>  20
<212>  PRT
<213>  Unknown

<220>
<223>  endosomal escape peptide

<400>  350

Gly Leu Phe His Ala Leu Leu His Leu Leu His Ser Leu Trp His Leu 
1               5                   10                  15      


Leu Leu His Ala 
            20  


<210>  351
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  endosomal escape peptide

<400>  351

His His His His His His His His His 
1               5                   


<210>  352
<211>  7
<212>  PRT
<213>  Betapolyomavirus macaca mulatta polyomavirus 1nuclear localization signal

<400>  352

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  353
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  353

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  354
<211>  9
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  354

Pro Ala Ala Lys Arg Val Lys Leu Asp 
1               5                   


<210>  355
<211>  11
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  355

Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Pro 
1               5                   10      


<210>  356
<211>  38
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  356

Asn Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly 
1               5                   10                  15      


Arg Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro 
            20                  25                  30          


Arg Asn Gln Gly Gly Tyr 
        35              


<210>  357
<211>  42
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  357

Arg Met Arg Ile Glx Phe Lys Asn Lys Gly Lys Asp Thr Ala Glu Leu 
1               5                   10                  15      


Arg Arg Arg Arg Val Glu Val Ser Val Glu Leu Arg Lys Ala Lys Lys 
            20                  25                  30          


Asp Glu Gln Ile Leu Lys Arg Arg Asn Val 
        35                  40          


<210>  358
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  358

Val Ser Arg Lys Arg Pro Arg Pro 
1               5               


<210>  359
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  359

Pro Pro Lys Lys Ala Arg Glu Asp 
1               5               


<210>  360
<211>  8
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  360

Pro Gln Pro Lys Lys Lys Pro Leu 
1               5               


<210>  361
<211>  12
<212>  PRT
<213>  Mus musculusnuclear localization signal

<400>  361

Ser Ala Leu Ile Lys Lys Lys Lys Lys Met Ala Pro 
1               5                   10          


<210>  362
<211>  5
<212>  PRT
<213>  Alphainfluenzavirus influenza A virusnuclear localization signal

<400>  362

Asp Arg Leu Arg Arg 
1               5   


<210>  363
<211>  7
<212>  PRT
<213>  Alphainfluenzavirus influenza A virusnuclear localization signal

<400>  363

Pro Lys Gln Lys Lys Arg Lys 
1               5           


<210>  364
<211>  10
<212>  PRT
<213>  Deltavirus  hepatitis delta virusnuclear localization signal

<400>  364

Arg Lys Leu Lys Lys Lys Ile Lys Lys Leu 
1               5                   10  


<210>  365
<211>  10
<212>  PRT
<213>  Mus musculusnuclear localization signal

<400>  365

Arg Glu Lys Lys Lys Phe Leu Lys Arg Arg 
1               5                   10  


<210>  366
<211>  20
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  366

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Val Ala Lys Lys 
1               5                   10                  15      


Lys Ser Lys Lys 
            20  


<210>  367
<211>  17
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  367

Arg Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys 
1               5                   10                  15      


Lys 
    


<210>  368
<211>  8
<212>  PRT
<213>  Orthobornavirus mammalian 1 orthobornavirusnuclear localization signal

<400>  368

Pro Arg Pro Arg Lys Ile Pro Arg 
1               5               


<210>  369
<211>  9
<212>  PRT
<213>  Hepacivirus  hepacivirus Cnuclear localization signal

<400>  369

Pro Pro Arg Lys Lys Arg Thr Val Val 
1               5                   


<210>  370
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  370

Asn Leu Ser Lys Lys Lys Lys Arg Lys Arg Glu Lys 
1               5                   10          


<210>  371
<211>  10
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  371

Arg Arg Pro Ser Arg Pro Phe Arg Lys Pro 
1               5                   10  


<210>  372
<211>  8
<212>  PRT
<213>  Lymphocryptovirus human gammaherpesvirus 4nuclear localization signal

<400>  372

Lys Arg Pro Arg Ser Pro Ser Ser 
1               5               


<210>  373
<211>  19
<212>  PRT
<213>  Alphainfluenzavirus influenza A virusnuclear localization signal

<400>  373

Lys Arg Gly Ile Asn Asp Arg Asn Phe Trp Arg Gly Glu Asn Glu Arg 
1               5                   10                  15      


Lys Thr Arg 
            


<210>  374
<211>  11
<212>  PRT
<213>  Homo sapiensnuclear localization signal

<400>  374

Pro Arg Pro Pro Lys Met Ala Arg Tyr Asp Asn 
1               5                   10      


<210>  375
<211>  8
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  375

Lys Arg Ser Phe Ser Lys Ala Phe 
1               5               


<210>  376
<211>  9
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  376

Lys Leu Lys Ile Lys Arg Pro Val Lys 
1               5                   


<210>  377
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  377

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  378
<211>  17
<212>  PRT
<213>  Deltaretrovirus human T-lymphotropic virus 1nuclear localization signal

<400>  378

Pro Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro 
1               5                   10                  15      


Thr 
    


<210>  379
<211>  24
<212>  PRT
<213>  Caenorhabditis elegansnuclear localization signal

<400>  379

Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala Lys 
1               5                   10                  15      


Lys Leu Ala Lys Glu Val Glu Asn 
            20                  


<210>  380
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  380

Lys Thr Arg Arg Arg Pro Arg Arg Ser Gln Arg Lys Arg Pro Pro Thr 
1               5                   10                  15      


<210>  381
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  381

Arg Arg Lys Lys Arg Arg Pro Arg Arg Lys Lys Arg Arg 
1               5                   10              


<210>  382
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  382

Pro Lys Lys Lys Ser Arg Lys Pro Lys Lys Lys Ser Arg Lys 
1               5                   10                  


<210>  383
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  383

His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210>  384
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  384

Gln Arg Pro Gly Pro Tyr Asp Arg Pro Gln Arg Pro Gly Pro Tyr Asp 
1               5                   10                  15      


Arg Pro 
        


<210>  385
<211>  16
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  385

Leu Ser Pro Ser Leu Ser Pro Leu Leu Ser Pro Ser Leu Ser Pro Leu 
1               5                   10                  15      


<210>  386
<211>  18
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  386

Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210>  387
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  387

Pro Lys Arg Gly Arg Gly Arg Pro Lys Arg Gly Arg Gly Arg 
1               5                   10                  


<210>  388
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  388

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala Lys Arg Val 
1               5                   10                  15      


Lys Leu Asp 
            


<210>  389
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  389

Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys Lys Arg Lys 
1               5                   10                  15      


Val 
    


<210>  390
<211>  11
<212>  PRT
<213>  Lentivirus human immunodeficiency viruspeptide transduction domain

<400>  390

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  391
<211>  8
<212>  PRT
<213>  Lentivirus human immunodeficiency viruspeptide transduction domain

<400>  391

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  392
<211>  11
<212>  PRT
<213>  Lentivirus human immunodeficiency viruspeptide transduction domain

<400>  392

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  393
<211>  11
<212>  PRT
<213>  Lentivirus human immunodeficiency viruspeptide transduction domain

<400>  393

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  394
<211>  11
<212>  PRT
<213>  Lentivirus human immunodeficiency viruspeptide transduction domain

<400>  394

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  395
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  peptide transduction domain

<400>  395

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  396
<211>  27
<212>  PRT
<213>  Unknown

<220>
<223>  peptide transduction domain

<400>  396

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  397
<211>  33
<212>  PRT
<213>  Unknown

<220>
<223>  peptide transduction domain

<400>  397

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  398
<211>  16
<212>  PRT
<213>  Drosophila melanogaster peptide transduction domain

<400>  398

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  399
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  399

Gly Ser Gly Gly Ser 
1               5   


<210>  400
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  400

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  401
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  401

Gly Gly Gly Ser 
1               


<210>  402
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  402

Gly Gly Ser Gly 
1               


<210>  403
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  403

Gly Gly Ser Gly Gly 
1               5   


<210>  404
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  404

Gly Ser Gly Ser Gly 
1               5   


<210>  405
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  405

Gly Ser Gly Gly Gly 
1               5   


<210>  406
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  406

Gly Gly Gly Ser Gly 
1               5   


<210>  407
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  407

Gly Ser Ser Ser Gly 
1               5   


<210>  408
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  408

Gly Pro Gly Pro 
1               


<210>  409
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  409

Pro Pro Ala Pro Pro Ala 
1               5       


<210>  410
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  410

Pro Pro Pro Gly Pro Pro Pro 
1               5           


<210>  411
<211>  25
<212>  PRT
<213>  Unknown

<220>
<223>  nuclear localization signal

<400>  411

Met Ser Arg Arg Arg Lys Ala Asn Pro Thr Lys Leu Ser Glu Asn Ala 
1               5                   10                  15      


Lys Lys Leu Ala Lys Glu Val Glu Asn 
            20                  25  


<210>  412
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  412
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  413
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  413
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  414
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  414
cctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  415
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  415
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  416
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  416
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  417
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  417
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  418
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  418
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  419
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  419
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  420
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  420
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  421
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  421
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  422
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  422
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  423
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  423
cctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  424
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  424
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  425
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  425
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  426
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  426
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  427
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  427
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  428
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  428
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  429
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  429
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tagtgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  430
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  430
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  431
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  431
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  432
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  432
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  433
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  433
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  434
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  434
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  435
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  435
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  436
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  436
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  437
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  437
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  438
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  438
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  439
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  439
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  440
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  440
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  441
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  441
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  442
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  442
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  443
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  443
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  444
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  444
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  445
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  445
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaccgataa ataagaagca tcaaag                     106


<210>  446
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  446
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  447
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  447
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  448
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  448
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  449
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  449
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  450
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  450
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  451
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  451
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  452
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  452
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  453
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  453
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  454
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  454
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  455
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  455
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  456
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  456
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  457
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  457
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  458
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  458
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  459
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  459
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  460
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  460
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  461
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  461
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  462
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  462
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  463
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  463
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  464
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  464
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  465
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  465
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  466
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  466
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  467
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  467
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  468
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  468
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  469
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  469
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  470
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  470
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  471
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  471
gctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  472
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  472
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatgcgg agagaaatcc gataaataag aagcatcaaa      120

g                                                                      121


<210>  473
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  473
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  474
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  474
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  475
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  475
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  476
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  476
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  477
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  477
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  478
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  478
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  479
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  479
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  480
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  480
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  481
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  481
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  482
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  482
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  483
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  483
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  484
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  484
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  485
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  485
tctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  486
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  486
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  487
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  487
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  488
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  488
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  489
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  489
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  490
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  490
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  491
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  491
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  492
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  492
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  493
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  493
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  494
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  494
tctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  495
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  495
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  496
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  496
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  497
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  497
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  498
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  498
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  499
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  499
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  500
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  500
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  501
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  501
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  502
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  502
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  503
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  503
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  504
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  504
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  505
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  505
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  506
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  506
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  507
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  507
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  508
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  508
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  509
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  509
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  510
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  510
tctggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  511
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  511
cctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  512
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  512
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctggagag aaatccgata aataagaagc atcaaag                    107


<210>  513
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  513
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  514
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  514
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  515
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  515
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  516
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  516
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  517
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  517
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  518
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  518
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  519
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  519
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  520
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  520
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  521
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  521
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  522
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  522
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  523
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  523
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  524
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  524
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  525
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  525
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  526
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  526
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  527
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  527
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  528
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  528
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  529
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  529
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  530
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  530
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  531
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  531
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  532
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  532
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  533
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  533
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  534
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  534
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  535
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  535
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  536
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  536
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  537
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  537
tcggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  538
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  538
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  539
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  539
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  540
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  540
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  541
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  541
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  542
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  542
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  543
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  543
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  544
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  544
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  545
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  545
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  546
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  546
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  547
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  547
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  548
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  548
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  549
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  549
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  550
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  550
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  551
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  551
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  552
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  552
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  553
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  553
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  554
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  554
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  555
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  555
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aaccgataaa taagaagcat caaag                      105


<210>  556
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  556
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  557
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  557
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  558
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  558
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  559
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  559
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  560
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  560
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  561
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  561
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  562
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  562
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  563
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  563
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  564
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  564
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  565
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  565
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  566
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  566
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  567
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  567
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  568
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  568
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  569
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  569
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  570
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  570
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  571
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  571
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  572
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  572
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  573
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  573
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  574
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  574
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  575
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  575
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  576
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  576
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  577
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  577
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  578
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  578
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagag aaatccgata aataagaagc atcaaag                    107


<210>  579
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  579
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  580
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  580
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  581
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  581
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  582
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  582
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  583
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  583
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  584
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  584
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  585
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  585
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaaa tccgataaat aagaagcatc aaag                       104


<210>  586
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  586
cctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  587
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  587
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  588
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  588
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aataccgata aataagaagc atcaaag                    107


<210>  589
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  589
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  590
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  590
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  591
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  591
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  592
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  592
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  593
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  593
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  594
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  594
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  595
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  595
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  596
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  596
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  597
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  597
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcctgata aataagaagc atcaaag                    107


<210>  598
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  598
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  599
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  599
cctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  600
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  600
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  601
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  601
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  602
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  602
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  603
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  603
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  604
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  604
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  605
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  605
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  606
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  606
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  607
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  607
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  608
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  608
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  609
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  609
actggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  610
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  610
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  611
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  611
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  612
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  612
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggacga aatccgataa ataagaagca tcaaag                     106


<210>  613
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  613
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  614
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  614
gctggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  615
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  615
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  616
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  616
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  617
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  617
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  618
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  618
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  619
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  619
actggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  620
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  620
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  621
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  621
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  622
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  622
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  623
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  623
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  624
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  624
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  625
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  625
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  626
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  626
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  627
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  627
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  628
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  628
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  629
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  629
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  630
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  630
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  631
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  631
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  632
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  632
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  633
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  633
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  634
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  634
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  635
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  635
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  636
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  636
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  637
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  637
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  638
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  638
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  639
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  639
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  640
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  640
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  641
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  641
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  642
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  642
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  643
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  643
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  644
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  644
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  645
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  645
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  646
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  646
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  647
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  647
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  648
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  648
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  649
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  649
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  650
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  650
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  651
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  651
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  652
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  652
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  653
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  653
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  654
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  654
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  655
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  655
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  656
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  656
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  657
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  657
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  658
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  658
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  659
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  659
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  660
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  660
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  661
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  661
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  662
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  662
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  663
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  663
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  664
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  664
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  665
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  665
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  666
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  666
cctggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  667
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  667
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  668
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  668
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  669
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  669
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  670
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  670
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  671
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  671
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  672
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  672
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  673
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  673
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  674
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  674
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  675
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  675
cctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  676
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  676
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  677
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  677
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  678
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  678
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  679
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  679
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  680
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  680
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  681
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  681
cctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  682
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  682
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  683
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  683
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagaa atccgataaa taagaagcat caaag                      105


<210>  684
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  684
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  685
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  685
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  686
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  686
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  687
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  687
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  688
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  688
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  689
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  689
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaagcgat aaataagaag catcaaag                   108


<210>  690
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  690
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  691
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  691
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  692
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  692
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  693
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  693
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  694
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  694
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  695
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  695
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  696
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  696
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  697
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  697
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  698
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  698
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  699
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  699
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  700
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  700
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  701
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  701
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  702
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  702
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcacgata aataagaagc atcaaag                    107


<210>  703
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  703
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  704
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  704
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagaa atccgataaa taagaagcat caaag                      105


<210>  705
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  705
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  706
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  706
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  707
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  707
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  708
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  708
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  709
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  709
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  710
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  710
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  711
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  711
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  712
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  712
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgact aaataagaag catcaaag                   108


<210>  713
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  713
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  714
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  714
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  715
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  715
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  716
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  716
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  717
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  717
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  718
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  718
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  719
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  719
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  720
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  720
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  721
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  721
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  722
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  722
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  723
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  723
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgtata aataagaagc atcaaag                    107


<210>  724
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  724
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  725
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  725
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  726
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  726
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  727
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  727
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  728
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  728
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  729
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  729
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  730
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  730
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  731
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  731
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  732
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  732
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtaga gaaatccgat aaataagaag catcaaag                   108


<210>  733
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  733
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  734
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  734
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  735
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  735
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  736
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  736
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  737
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  737
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  738
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  738
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  739
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  739
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  740
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  740
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  741
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  741
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  742
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  742
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  743
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  743
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  744
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  744
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  745
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  745
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  746
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  746
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  747
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  747
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  748
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  748
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  749
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  749
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  750
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  750
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgaata aataagaagc atcaaag                    107


<210>  751
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  751
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  752
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  752
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  753
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  753
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  754
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  754
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  755
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  755
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  756
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  756
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  757
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  757
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agagtccgat aaataagaag catcaaag                   108


<210>  758
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  758
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  759
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  759
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  760
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  760
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  761
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  761
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  762
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  762
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  763
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  763
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  764
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  764
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  765
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  765
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  766
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  766
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  767
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  767
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  768
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  768
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  769
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  769
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagag aaatccgata aataagaagc atcaaag                    107


<210>  770
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  770
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtat aaataagaag catcaaag                   108


<210>  771
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  771
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  772
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  772
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  773
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  773
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  774
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  774
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  775
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  775
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  776
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  776
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgtgagaa atccgataaa taagaagcat caaag                      105


<210>  777
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  777
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattgataa ataagaagca tcaaag                     106


<210>  778
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  778
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  779
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  779
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  780
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  780
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  781
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  781
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta atccgataaa taagaagcat caaag                      105


<210>  782
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  782
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  783
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  783
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  784
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  784
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  785
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  785
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  786
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  786
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aattgataaa taagaagcat caaag                      105


<210>  787
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  787
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  788
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  788
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agtccgataa ataagaagca tcaaag                     106


<210>  789
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  789
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgagt aaataagaag catcaaag                   108


<210>  790
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  790
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  791
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  791
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  792
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  792
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  793
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  793
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  794
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  794
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  795
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  795
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  796
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  796
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaatccgat aaataagaag catcaaag                   108


<210>  797
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  797
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  798
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  798
tactggcgct tttatctcat tactttagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  799
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  799
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  800
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  800
cctggcgctt ttatctcatt actttgtaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  801
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  801
ctggcgcttt tatctcatta ctttcgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  802
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  802
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  803
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  803
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  804
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  804
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  805
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  805
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  806
<211>  121
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  806
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatacgg agagaaatcc gataaataag aagcatcaaa      120

g                                                                      121


<210>  807
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  807
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  808
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  808
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  809
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  809
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  810
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  810
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  811
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  811
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  812
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  812
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  813
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  813
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  814
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  814
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  815
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  815
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  816
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  816
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  817
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  817
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  818
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  818
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  819
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  819
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctggaga gaaatccgat aaataagaag catcaaag                   108


<210>  820
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  820
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  821
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  821
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  822
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  822
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctagagaaa tccgataaat aagaagcatc aaag                       104


<210>  823
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  823
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcaga gaaatccgat aaataagaag catcaaag                   108


<210>  824
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  824
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  825
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  825
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  826
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  826
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagca aatccgataa ataagaagca tcaaag                     106


<210>  827
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  827
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga aaataagaag catcaaag                   108


<210>  828
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  828
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  829
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  829
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  830
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  830
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  831
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  831
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  832
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  832
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcaagagaaa tccgataaat aagaagcatc aaag                       104


<210>  833
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  833
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  834
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  834
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  835
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  835
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  836
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  836
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  837
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  837
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  838
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  838
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  839
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  839
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  840
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  841
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  841
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  842
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  842
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  843
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  843
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aagcgataaa taagaagcat caaag                      105


<210>  844
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  844
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  845
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  845
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  846
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  846
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  847
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  847
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  848
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  848
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  849
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  849
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  850
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  850
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  851
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  851
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  852
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  852
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  853
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  853
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  854
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  854
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  855
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  855
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  856
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  856
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  857
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  857
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  858
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  858
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  859
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  859
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagccgataa ataagaagca tcaaag                     106


<210>  860
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  860
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  861
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  861
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  862
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  862
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  863
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  863
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  864
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  864
tactggcgct tttatctcat tactttgcag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  865
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  865
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  866
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  866
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcggtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  867
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  867
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  868
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  868
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  869
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  869
gctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  870
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  870
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagtg aaatccgata aataagaagc atcaaag                    107


<210>  871
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  871
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  872
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  872
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  873
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  873
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  874
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  874
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  875
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  875
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  876
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  876
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  877
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  877
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  878
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  878
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  879
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  879
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  880
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  880
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  881
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  881
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  882
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  882
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  883
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  883
cctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  884
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  884
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  885
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  885
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  886
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  886
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  887
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  887
tctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  888
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  888
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  889
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  889
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  890
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  890
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tactcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  891
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  891
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  892
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  892
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  893
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  893
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  894
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  894
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  895
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  895
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  896
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  896
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  897
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  897
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  898
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  898
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  899
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  899
tactggcgct tttatctcat tactttgtag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  900
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  900
ctggcgcttt tatctcatta ctttagagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  901
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  901
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgcgagaa atccgataaa taagaagcat caaag                      105


<210>  902
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  902
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta atccgataaa taagaagcat caaag                      105


<210>  903
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  903
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  904
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  904
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  905
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  905
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  906
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  906
tacggcgctt ttatctcatt actttcgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  907
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  907
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  908
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  908
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  909
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  909
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attgagagaa atccgataaa taagaagcat caaag                      105


<210>  910
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  910
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  911
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  911
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  912
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  912
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  913
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  913
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgtaaa taagaagcat caaag                      105


<210>  914
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  914
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  915
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  915
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  916
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  916
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcaagagaaa tccgataaat aagaagcatc aaag                       104


<210>  917
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  917
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  918
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  918
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  919
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  919
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  920
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  920
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  921
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  921
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagcaa atccgataaa taagaagcat caaag                      105


<210>  922
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  922
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  923
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  923
gctggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  924
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  924
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  925
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  925
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  926
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  926
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  927
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  927
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  928
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  928
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcagata aataagaagc atcaaag                    107


<210>  929
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  929
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  930
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  930
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagca aatccgataa ataagaagca tcaaag                     106


<210>  931
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  931
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  932
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  932
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaatccgat aaataagaag catcaaag                   108


<210>  933
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  933
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggaa ataagaagca tcaaag                     106


<210>  934
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  934
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag actccgataa ataagaagca tcaaag                     106


<210>  935
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  935
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  936
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  936
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aaacgataaa taagaagcat caaag                      105


<210>  937
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  937
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  938
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  938
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  939
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  939
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  940
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  940
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  941
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  941
tacggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  942
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  942
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  943
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  943
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatggaga gaaatccgat aaataagaag catcaaag                   108


<210>  944
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  944
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  945
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  945
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  946
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  946
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  947
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  947
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  948
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  948
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  949
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  949
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  950
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  950
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  951
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  951
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgcata aataagaagc atcaaag                    107


<210>  952
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  952
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  953
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  953
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  954
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  954
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atggagagaa atccgataaa taagaagcat caaag                      105


<210>  955
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  955
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  956
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  956
actggcgctt ttatctcatt actttagaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  957
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  957
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  958
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  958
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  959
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  959
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  960
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  960
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  961
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  961
actggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  962
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  962
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  963
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  963
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  964
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  964
gctggcgctt ttatcttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  965
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  965
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  966
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  966
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagagagc atcaaag                    107


<210>  967
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  967
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  968
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  968
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  969
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  969
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatggataa ataagaagca tcaaag                     106


<210>  970
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  970
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  971
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  971
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  972
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  972
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  973
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  973
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  974
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  974
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga aatccgataa ataagaagca tcaaag                     106


<210>  975
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  975
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgaaa ataagaagca tcaaag                     106


<210>  976
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  976
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  977
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  977
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  978
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  978
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  979
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  979
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  980
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  980
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  981
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  981
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  982
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  982
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acccgataaa taagaagcat caaag                      105


<210>  983
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  983
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  984
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  984
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  985
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  985
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  986
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  986
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  987
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  987
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  988
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  988
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  989
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  989
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  990
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  990
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  991
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  991
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccagagaaa tccgataaat aagaagcatc aaag                       104


<210>  992
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  992
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  993
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  993
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  994
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  994
actggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  995
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  995
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgaaaa taagaagcat caaag                      105


<210>  996
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  996
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  997
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  997
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  998
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  998
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccggt aaataagaag catcaaag                   108


<210>  999
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  999
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  1000
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1000
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  1001
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1001
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1002
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1002
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1003
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1003
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  1004
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1004
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1005
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1005
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1006
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1006
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1007
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1007
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1008
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1008
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1009
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1009
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  1010
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1010
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1011
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1011
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgaa atccgataaa taagaagcat caaag                      105


<210>  1012
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1012
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  1013
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1013
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1014
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1014
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  1015
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1015
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1016
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1016
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcagat aaataagaag catcaaag                   108


<210>  1017
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1017
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1018
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1018
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1019
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1019
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1020
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1020
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  1021
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1021
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1022
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1022
tctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1023
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1023
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  1024
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1024
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1025
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1025
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1026
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1026
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagccgataa ataagaagca tcaaag                     106


<210>  1027
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1027
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1028
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1028
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  1029
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1029
cctggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1030
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1030
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1031
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1031
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaaatccgat aaataagaag catcaaag                   108


<210>  1032
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1032
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1033
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1033
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1034
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1034
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1035
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1035
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1036
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1037
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1037
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1038
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1038
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  1039
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1039
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccat aaataagaag catcaaag                   108


<210>  1040
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1040
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1041
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1041
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1042
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1042
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1043
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1043
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1044
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1044
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tcttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1045
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1045
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1046
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1046
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1047
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1047
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  1048
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1048
ttactggcgc ttttatctca ttactttcga gagccatcac cagcgactat gtcgtatggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1049
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  1050
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1050
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt actcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1051
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1051
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1052
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1052
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1053
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1053
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1054
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1054
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtagag aaatccgata aataagaagc atcaaag                    107


<210>  1055
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1055
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1056
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1056
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1057
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1057
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagag aaatccgata aataagaagc atcaaag                    107


<210>  1058
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1058
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1059
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1059
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcagagaa atccgataaa taagaagcat caaag                      105


<210>  1060
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1060
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1061
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1061
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1062
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1062
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  1063
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1063
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1064
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1064
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1065
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1065
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1066
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1066
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  1067
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1067
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1068
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1068
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1069
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1069
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1070
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1070
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agacaatccg ataaataaga agcatcaaag                 110


<210>  1071
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1071
gctggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1072
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1072
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  1073
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1073
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaggaa atccgataaa taagaagcat caaag                      105


<210>  1074
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1074
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1075
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1075
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1076
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1076
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaaag catcaaag                   108


<210>  1077
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1077
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  1078
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1078
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1079
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1079
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  1080
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1080
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1081
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1082
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1082
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1083
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1083
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1084
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1084
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1085
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1085
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1086
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1086
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1087
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1087
tctggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1088
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1088
actggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1089
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1089
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1090
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1090
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1091
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1091
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1092
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1092
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1093
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1093
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1094
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1094
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcgat aaataagaag catcaaag                   108


<210>  1095
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1095
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1096
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1096
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  1097
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1097
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1098
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1098
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1099
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1099
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1100
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1100
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatgccgata aataagaagc atcaaag                    107


<210>  1101
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1101
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  1102
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1102
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1103
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1103
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1104
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1104
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga gtccgataaa taagaagcat caaag                      105


<210>  1105
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1105
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctggagag aaatccgata aataagaagc atcaaag                    107


<210>  1106
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1106
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  1107
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1107
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1108
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1108
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcattattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1109
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1109
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1110
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1110
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  1111
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1111
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tattgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1112
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1112
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1113
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1113
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1114
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1114
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1115
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1115
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1116
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1116
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caatccgata aataagaagc atcaaag                    107


<210>  1117
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1117
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat gaataagaag catcaaag                   108


<210>  1118
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1118
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaagcgat aaataagaag catcaaag                   108


<210>  1119
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1119
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1120
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1120
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1121
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1121
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gatccgataa ataagaagca tcaaag                     106


<210>  1122
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1122
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1123
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1123
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaacgataa ataagaagca tcaaag                     106


<210>  1124
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1124
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1125
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1125
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcacgata aataagaagc atcaaag                    107


<210>  1126
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1126
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgtttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1127
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1127
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1128
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1128
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  1129
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1129
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggattt ctctccgata aataagaagc atcaaag                    107


<210>  1130
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1130
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgataaa taagaagcat caaag                      105


<210>  1131
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1131
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1132
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1132
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1133
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1133
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1134
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1134
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  1135
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1135
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1136
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1136
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1137
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1137
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1138
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1138
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1139
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1139
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1140
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1140
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1141
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1141
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1142
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1142
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1143
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1143
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agccttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1144
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1144
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1145
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1145
actggcgctt ttatctcatt actttagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1146
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1146
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1147
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1147
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga tccgataaat aagaagcatc aaag                       104


<210>  1148
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1148
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1149
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1149
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaggaa atccgataaa taagaagcat caaag                      105


<210>  1150
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1150
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1151
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1151
tacggcgctt ttatctcatt actttgcaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1152
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1152
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1153
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1153
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1154
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1154
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1155
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1155
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaacgataaa taagaagcat caaag                      105


<210>  1156
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1156
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1157
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1157
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1158
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1158
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1159
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1159
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  1160
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1160
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1161
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1161
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1162
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1162
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1163
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1163
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1164
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1164
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1165
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1165
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1166
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1166
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  1167
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1167
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1168
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1168
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1169
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1169
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1170
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1170
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1171
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1171
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtgaga aatccgataa ataagaagca tcaaag                     106


<210>  1172
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1172
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggat ttctctccga taaataagaa gcatcaaag                  109


<210>  1173
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1173
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1174
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1174
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1175
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1175
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt atatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1176
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1176
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1177
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1177
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag agaaatccga taaataagaa gcatcaaag                  109


<210>  1178
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1178
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  1179
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1179
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1180
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1180
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaaccgataa ataagaagca tcaaag                     106


<210>  1181
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1181
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1182
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1182
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta aataagaagc atcaaag                    107


<210>  1183
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1183
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caaatccgat aaataagaag catcaaag                   108


<210>  1184
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1184
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga ttccgataaa taagaagcat caaag                      105


<210>  1185
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1185
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1186
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1186
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1187
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1187
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1188
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1188
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  1189
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1189
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1190
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1190
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1191
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1191
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1192
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1192
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1193
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1193
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1194
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1194
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1195
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1195
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1196
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1196
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1197
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1197
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1198
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1198
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1199
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1199
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaacgataa ataagaagca tcaaag                     106


<210>  1200
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1200
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1201
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1201
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1202
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1202
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1203
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1203
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat ccggagagaa atccgataaa taagaagcat caaag                      105


<210>  1204
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1204
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1205
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1205
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1206
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1206
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1207
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1207
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1208
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1208
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1209
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1209
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1210
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1210
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgaa taaataagaa gcatcaaag                  109


<210>  1211
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1211
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1212
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1212
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt taggagagaa atccgataaa taagaagcat caaag                      105


<210>  1213
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1213
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1214
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1214
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1215
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1215
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1216
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1216
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1217
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1217
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1218
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1218
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1219
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1219
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1220
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1220
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcagag aaatccgata aataagaagc atcaaag                    107


<210>  1221
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1221
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1222
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1222
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  1223
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1223
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1224
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1224
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1225
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1225
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ttccgataaa taagaagcat caaag                      105


<210>  1226
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1226
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1227
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1227
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgataaat aagaagcatc aaag                       104


<210>  1228
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1228
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1229
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1229
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1230
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1230
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1231
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1231
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1232
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1232
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agatccgata aataagaagc atcaaag                    107


<210>  1233
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1233
actggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1234
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1234
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtgaga aatccgataa ataagaagca tcaaag                     106


<210>  1235
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1235
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1236
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1236
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgag aaatccgata aataagaagc atcaaag                    107


<210>  1237
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1237
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1238
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1238
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  1239
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1239
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1240
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1240
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatagaga gaaatccgat aaataagaag catcaaag                   108


<210>  1241
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1241
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  1242
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1242
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1243
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1243
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1244
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1244
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1245
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1245
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1246
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1246
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccat aaataagaag catcaaag                   108


<210>  1247
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1247
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1248
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1248
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1249
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1249
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1250
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1250
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1251
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1251
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1252
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1252
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg aataagaagc atcaaag                    107


<210>  1253
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1253
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1254
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1254
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1255
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1255
ctggcgcttt tatcttcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1256
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1256
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1257
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1257
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1258
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1258
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1259
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1259
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1260
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1260
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1261
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1261
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttgtatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1262
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1262
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  1263
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1263
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1264
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1264
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1265
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1265
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1266
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1266
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1267
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1267
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag caaatccgat aaataagaag catcaaag                   108


<210>  1268
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1268
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1269
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1269
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1270
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1270
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1271
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1271
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1272
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1272
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1273
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1273
tactggcgct tttatctcat tactttgctc attactttga gagccatcac cagcgactat       60

gtcgtatggg taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag      120


<210>  1274
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1274
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  1275
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1275
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  1276
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1276
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtattgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1277
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1277
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1278
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1278
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1279
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1279
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1280
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1280
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1281
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1281
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg ataagaagca tcaaag                     106


<210>  1282
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1282
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  1283
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1283
cctggcgctt ttaatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1284
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1284
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1285
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1285
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1286
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1286
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1287
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1287
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa agcatcaaag                 110


<210>  1288
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1288
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga gtaaataaga agcatcaaag                 110


<210>  1289
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1289
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1290
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1290
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1291
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1291
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata tccgataaat aagaagcatc aaag                       104


<210>  1292
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1292
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagag aaatccgata aataagaagc atcaaag                    107


<210>  1293
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1293
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1294
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1294
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1295
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1295
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1296
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1296
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1297
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1297
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1298
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1298
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  1299
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1299
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  1300
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1300
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1301
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1301
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1302
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1302
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1303
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1303
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  1304
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1304
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  1305
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1305
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1306
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1306
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgg ataaataaga agcatcaaag                 110


<210>  1307
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1307
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1308
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1308
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1309
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1309
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaatccgata aataagaagc atcaaag                    107


<210>  1310
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1310
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggaa atccgataaa taagaagcat caaag                      105


<210>  1311
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1311
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1312
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1312
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1313
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1313
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1314
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1314
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1315
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1315
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  1316
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1316
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1317
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1317
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1318
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1318
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggattt ctctccgata aataagaagc atcaaag                    107


<210>  1319
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1319
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1320
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1320
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1321
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1321
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1322
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1322
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1323
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1323
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1324
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1324
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1325
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1325
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1326
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1326
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcattattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1327
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1327
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga atccgataaa taagaagcat caaag                      105


<210>  1328
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1328
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1329
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1329
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1330
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1330
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1331
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1331
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gattccgata aataagaagc atcaaag                    107


<210>  1332
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1332
ctggcgcttt tattctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1333
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1333
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1334
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1334
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1335
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1335
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1336
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1336
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1337
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1337
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1338
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1338
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1339
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1339
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  1340
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1340
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1341
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1341
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1342
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1342
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1343
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1343
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1344
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1344
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1345
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1345
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctgat aaataagaag catcaaag                   108


<210>  1346
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1346
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1347
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1347
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1348
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1348
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1349
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1349
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1350
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1350
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1351
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1351
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1352
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1352
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1353
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1353
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1354
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1354
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1355
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1355
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1356
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1356
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1357
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1357
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatatccgat aaataagaag catcaaag                   108


<210>  1358
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1358
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1359
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1359
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1360
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1360
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1361
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1361
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1362
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1362
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1363
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1363
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1364
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1364
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1365
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1365
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1366
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1366
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1367
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1367
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1368
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1368
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1369
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1369
tctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1370
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1370
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa agcatcaaag                 110


<210>  1371
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1371
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1372
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1372
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1373
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1373
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agataatccg ataaataaga agcatcaaag                 110


<210>  1374
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1374
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1375
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1375
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1376
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1376
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcta aataagaagc atcaaag                    107


<210>  1377
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1377
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1378
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1378
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1379
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1379
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1380
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1380
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1381
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1381
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1382
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1382
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1383
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1383
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1384
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1384
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1385
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1385
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1386
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1386
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1387
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1387
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1388
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1388
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggggag aaatccgata aataagaagc atcaaag                    107


<210>  1389
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1389
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1390
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1390
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1391
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1391
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1392
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1392
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1393
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1393
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  1394
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1394
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggaagaaa tccgataaat aagaagcatc aaag                       104


<210>  1395
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1395
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  1396
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1396
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1397
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1397
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1398
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1398
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  1399
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1399
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga tatccgataa ataagaagca tcaaag                     106


<210>  1400
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1400
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1401
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1401
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatttagag aaatccgata aataagaagc atcaaag                    107


<210>  1402
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1402
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tccggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1403
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1403
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1404
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1404
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atagagagaa atccgataaa taagaagcat caaag                      105


<210>  1405
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1405
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1406
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1406
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1407
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1407
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga aatccgataa ataagaagca tcaaag                     106


<210>  1408
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1408
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1409
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1409
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1410
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1410
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1411
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1411
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1412
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1412
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcgggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1413
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1413
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccggtaa ataagaagca tcaaag                     106


<210>  1414
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1414
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1415
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1415
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1416
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1416
tcggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1417
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1417
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1418
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1418
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1419
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1419
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  1420
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1420
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1421
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1421
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1422
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1422
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatt aaataagaag catcaaag                   108


<210>  1423
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1423
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1424
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1424
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1425
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1425
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1426
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1426
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1427
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1427
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1428
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1428
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1429
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1429
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agcatccgat aaataagaag catcaaag                   108


<210>  1430
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1430
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1431
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1431
gctggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1432
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1432
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta taaataagaa gcatcaaag                  109


<210>  1433
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1433
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga taatccgata aataagaagc atcaaag                    107


<210>  1434
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1434
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1435
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1435
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  1436
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1436
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1437
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1437
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1438
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1438
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga gtccgataaa taagaagcat caaag                      105


<210>  1439
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1439
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1440
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1440
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaatccgat aaataagaag catcaaag                   108


<210>  1441
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1441
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1442
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1442
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1443
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1443
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  1444
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1444
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1445
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1445
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1446
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1446
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1447
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1447
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaagagaa atccgataaa taagaagcat caaag                      105


<210>  1448
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1448
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tctcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1449
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1449
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  1450
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1450
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1451
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1451
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1452
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1452
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1453
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1453
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagtaagc atcaaag                    107


<210>  1454
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1454
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  1455
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1455
tactggcgct tttatctcat tactttagag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1456
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1456
tctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1457
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1457
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1458
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1458
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcggtat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1459
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1459
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1460
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1460
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagtaa atccgataaa taagaagcat caaag                      105


<210>  1461
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1461
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  1462
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1462
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1463
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1463
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1464
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1464
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1465
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1465
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattgataa ataagaagca tcaaag                     106


<210>  1466
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1466
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga aatccgataa ataagaagca tcaaag                     106


<210>  1467
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1467
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt ctcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1468
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1468
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1469
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1469
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1470
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1470
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  1471
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1471
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  1472
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1472
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1473
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1473
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  1474
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1474
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1475
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1475
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1476
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1476
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1477
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1477
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1478
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1478
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  1479
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1479
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1480
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1480
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagctttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1481
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1481
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1482
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1482
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1483
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1483
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aacatccgat aaataagaag catcaaag                   108


<210>  1484
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1484
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1485
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1485
taaggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1486
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1486
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag acaatccgat aaataagaag catcaaag                   108


<210>  1487
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1487
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1488
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1488
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1489
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1489
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgaa atccgataaa taagaagcat caaag                      105


<210>  1490
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1490
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1491
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1491
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1492
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1492
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1493
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1493
ctggcgcttt tatctctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1494
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1494
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttgtatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1495
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1495
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata tataagaagc atcaaag                    107


<210>  1496
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1496
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1497
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1497
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1498
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1498
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag ataatccgat aaataagaag catcaaag                   108


<210>  1499
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1499
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1500
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1500
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga aaataagaag catcaaag                   108


<210>  1501
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1501
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccggaaa taagaagcat caaag                      105


<210>  1502
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1502
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggggaga aatccgataa ataagaagca tcaaag                     106


<210>  1503
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1503
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1504
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1504
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1505
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1505
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1506
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1506
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1507
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1507
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccagagaa atccgataaa taagaagcat caaag                      105


<210>  1508
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1508
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga caatccgata aataagaagc atcaaag                    107


<210>  1509
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1509
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  1510
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1510
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  1511
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1511
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1512
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1512
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgggagaaat ccgataaata agaagcatca aag                        103


<210>  1513
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1513
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  1514
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1514
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  1515
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1515
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1516
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1516
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1517
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1517
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga accgataaat aagaagcatc aaag                       104


<210>  1518
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1518
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1519
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1519
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaaa tccgataaat aagaagcatc aaag                       104


<210>  1520
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1520
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1521
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1521
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1522
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1522
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1523
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1523
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tccagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1524
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1524
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1525
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1525
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1526
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1526
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  1527
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1527
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1528
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1528
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tcatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1529
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1529
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1530
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1530
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1531
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1531
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1532
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1532
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1533
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1533
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1534
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1534
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttatttt cggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1535
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1535
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1536
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1536
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taatccgata aataagaagc atcaaag                    107


<210>  1537
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1537
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1538
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1538
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1539
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1539
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1540
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1540
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1541
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1541
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaccgataaa taagaagcat caaag                      105


<210>  1542
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1542
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcgat aaataagaag catcaaag                   108


<210>  1543
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1543
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1544
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1544
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg aataagaagc atcaaag                    107


<210>  1545
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1545
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1546
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1546
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1547
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1547
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1548
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1548
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagagag catcaaag                   108


<210>  1549
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1549
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1550
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1550
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1551
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1551
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1552
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1552
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1553
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1553
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1554
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1554
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatagagaga aatccgataa ataagaagca tcaaag                     106


<210>  1555
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1555
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1556
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1556
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  1557
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1557
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1558
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1558
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1559
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1559
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1560
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1560
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1561
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1561
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1562
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1562
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaaag catcaaag                   108


<210>  1563
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1563
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  1564
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1564
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaagatccg ataaataaga agcatcaaag                 110


<210>  1565
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1565
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggcagaga aatccgataa ataagaagca tcaaag                     106


<210>  1566
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1566
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1567
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1567
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1568
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1568
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1569
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1569
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgagagaaat ccgataaata agaagcatca aag                        103


<210>  1570
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1570
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1571
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1571
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1572
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1572
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagtccgat aaataagaag catcaaag                   108


<210>  1573
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1573
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1574
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1574
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1575
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1575
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1576
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1576
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1577
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1577
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1578
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1578
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1579
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1579
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1580
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1580
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1581
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1581
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1582
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1582
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1583
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1583
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1584
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1584
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1585
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1585
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1586
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1586
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1587
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1587
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaataccgat aaataagaag catcaaag                   108


<210>  1588
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1588
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1589
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1589
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag agaatccgat aaataagaag catcaaag                   108


<210>  1590
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1590
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  1591
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1591
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1592
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1592
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1593
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1593
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  1594
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1594
gctggcgctt ttatctctat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1595
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1595
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1596
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1596
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttctcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1597
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1597
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1598
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1598
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaacgataaa taagaagcat caaag                      105


<210>  1599
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1599
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1600
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1600
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1601
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1601
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  1602
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1602
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  1603
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1603
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa gaaatccgat aaataagaag catcaaag                   108


<210>  1604
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1604
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1605
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1605
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1606
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1606
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1607
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1607
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1608
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1608
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1609
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1609
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1610
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1610
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1611
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1611
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcggtat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1612
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1612
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1613
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1613
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1614
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1614
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1615
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1615
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggtg agaaatccga taaataagaa gcatcaaag                  109


<210>  1616
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1616
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1617
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1617
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gaaatccgat aaataagaag catcaaag                   108


<210>  1618
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1618
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  1619
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1619
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgatg ataagaagca tcaaag                     106


<210>  1620
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1620
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gctttattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1621
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1621
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctgagaa atccgataaa taagaagcat caaag                      105


<210>  1622
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1622
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1623
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1623
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1624
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1624
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1625
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1625
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgatattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1626
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1626
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1627
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1627
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgg ataaataaga agcatcaaag                 110


<210>  1628
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1628
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1629
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1629
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1630
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1630
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1631
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1631
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1632
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1632
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1633
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1633
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  1634
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1634
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  1635
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1635
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1636
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1636
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1637
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1637
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1638
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1638
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  1639
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1639
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1640
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1640
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcattattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  1641
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1641
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1642
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1642
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1643
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1643
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1644
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1644
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  1645
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1645
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  1646
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1646
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggcgaga aatccgataa ataagaagca tcaaag                     106


<210>  1647
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1647
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1648
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1648
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1649
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1649
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  1650
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1650
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1651
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1651
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1652
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1652
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1653
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1653
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1654
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1654
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agacaatccg ataaataaga agcatcaaag                 110


<210>  1655
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1655
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagaaat ccgataaata agaagcatca aag                        103


<210>  1656
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1656
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1657
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1657
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1658
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1658
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1659
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1659
tacggcgctt ttatcctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1660
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1660
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1661
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1661
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagtaag catcaaag                   108


<210>  1662
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1662
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta ttgagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1663
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1663
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgga aataagaagc atcaaag                    107


<210>  1664
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1664
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1665
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1665
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcta aataagaagc atcaaag                    107


<210>  1666
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1666
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1667
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1667
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1668
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1668
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  1669
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1669
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1670
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1670
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1671
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1671
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1672
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1672
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccataaa taagaagcat caaag                      105


<210>  1673
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1673
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  1674
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1674
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1675
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1675
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcga gaaatccgat aaataagaag catcaaag                   108


<210>  1676
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1676
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  1677
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1677
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1678
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1678
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1679
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1679
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattc tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1680
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1680
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1681
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1681
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aagtccgata aataagaagc atcaaag                    107


<210>  1682
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1682
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gaaatccgat aaataagaag catcaaag                   108


<210>  1683
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1683
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  1684
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1684
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1685
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1685
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaca atccgataaa taagaagcat caaag                      105


<210>  1686
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1686
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1687
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1687
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1688
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1688
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1689
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1689
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1690
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1690
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1691
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1691
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1692
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1692
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1693
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1693
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  1694
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1694
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1695
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1695
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgagagaaat ccgataaata agaagcatca aag                        103


<210>  1696
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1696
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  1697
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1697
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1698
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1698
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagataaat aagaagcatc aaag                       104


<210>  1699
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1699
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1700
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1700
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1701
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1701
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  1702
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1702
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1703
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1703
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1704
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1704
tactggcgct tttatcgtca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1705
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1705
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcgcgataa ataagaagca tcaaag                     106


<210>  1706
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1706
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  1707
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1707
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatagataa ataagaagca tcaaag                     106


<210>  1708
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1708
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1709
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1709
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1710
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1710
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1711
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1711
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1712
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1712
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgcat aaataagaag catcaaag                   108


<210>  1713
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1713
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1714
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1714
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1715
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1715
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1716
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1716
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1717
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1717
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cgggagaaat ccgataaata agaagcatca aag                        103


<210>  1718
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1718
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1719
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1719
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1720
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1720
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1721
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1721
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggatgaa atccgataaa taagaagcat caaag                      105


<210>  1722
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1722
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1723
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1723
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1724
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1724
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagag aaatccgata aataagaagc atcaaag                    107


<210>  1725
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1725
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1726
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1726
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1727
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1727
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1728
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1728
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  1729
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1729
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1730
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1730
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1731
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1731
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1732
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1732
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atccggagag aaatccgata aataagaagc atcaaag                    107


<210>  1733
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1733
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  1734
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1734
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1735
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1735
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1736
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1736
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1737
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1737
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1738
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1738
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1739
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1739
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1740
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1740
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1741
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1741
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1742
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1742
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  1743
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1743
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  1744
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1744
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atctagagaa atccgataaa taagaagcat caaag                      105


<210>  1745
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1745
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggaggaaa tccgataaat aagaagcatc aaag                       104


<210>  1746
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1746
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatacgata aataagaagc atcaaag                    107


<210>  1747
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1747
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1748
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1748
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1749
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1749
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtcag aaatccgata aataagaagc atcaaag                    107


<210>  1750
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1750
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  1751
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1751
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaatccgat aaataagaag catcaaag                   108


<210>  1752
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1752
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  1753
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1753
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgtagag aaatccgata aataagaagc atcaaag                    107


<210>  1754
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1754
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1755
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1755
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1756
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1756
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctgata aataagaagc atcaaag                    107


<210>  1757
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1757
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcccgat aaataagaag catcaaag                   108


<210>  1758
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1758
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1759
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1759
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1760
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1760
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat cggagagaaa tccgataaat aagaagcatc aaag                       104


<210>  1761
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1761
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagta agcatcaaag                 110


<210>  1762
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1762
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1763
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1763
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1764
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1764
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1765
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1765
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1766
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1766
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1767
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1767
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1768
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1768
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  1769
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1769
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  1770
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1770
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  1771
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1771
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1772
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1772
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1773
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1773
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1774
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1774
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggta aataagaagc atcaaag                    107


<210>  1775
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1775
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaagcgata aataagaagc atcaaag                    107


<210>  1776
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1776
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1777
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1777
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagata atccgataaa taagaagcat caaag                      105


<210>  1778
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1778
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagta aatccgataa ataagaagca tcaaag                     106


<210>  1779
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1779
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1780
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1780
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1781
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1781
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1782
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1782
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1783
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1783
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1784
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1784
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcagga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1785
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1785
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag ataatccgat aaataagaag catcaaag                   108


<210>  1786
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1786
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1787
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1787
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1788
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1788
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1789
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1789
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaacgata aataagaagc atcaaag                    107


<210>  1790
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1790
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcctgata aataagaagc atcaaag                    107


<210>  1791
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1791
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1792
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1792
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1793
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1793
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1794
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1794
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgcagag aaatccgata aataagaagc atcaaag                    107


<210>  1795
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1795
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1796
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1796
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1797
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1797
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag atccgataaa taagaagcat caaag                      105


<210>  1798
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1798
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1799
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1799
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1800
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1800
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1801
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1801
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1802
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1802
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1803
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1803
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1804
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1804
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1805
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1805
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgt aaataagaag catcaaag                   108


<210>  1806
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1806
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1807
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1807
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1808
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1808
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1809
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1809
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1810
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1810
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1811
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1811
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgag taaataagaa gcatcaaag                  109


<210>  1812
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1812
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1813
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1813
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1814
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1814
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttataaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1815
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1815
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1816
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1816
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1817
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1817
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1818
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1818
cctggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1819
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1819
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  1820
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1820
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  1821
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1821
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaaa gaaatccgat aaataagaag catcaaag                   108


<210>  1822
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1822
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1823
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1823
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1824
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1824
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1825
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1825
cctggcgctt ttatctacat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1826
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1826
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1827
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1827
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1828
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1828
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1829
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1829
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1830
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1830
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1831
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1831
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1832
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1832
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1833
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1833
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1834
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1834
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  1835
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1835
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagatag catcaaag                   108


<210>  1836
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1836
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1837
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1837
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1838
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1838
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1839
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1839
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  1840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1840
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccat aaataagaag catcaaag                   108


<210>  1841
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1841
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1842
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1842
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1843
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1843
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1844
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1844
tactggcgct tttatctcat tactttcgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatggat aaataagaag catcaaag                   108


<210>  1845
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1845
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccct aaataagaag catcaaag                   108


<210>  1846
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1846
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaagcgataa ataagaagca tcaaag                     106


<210>  1847
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1847
cctggcgctt ttatctcaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1848
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1848
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccat aaataagaag catcaaag                   108


<210>  1849
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1849
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1850
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1850
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  1851
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1851
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttatatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1852
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1852
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1853
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1853
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  1854
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1854
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  1855
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1855
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1856
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1856
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga gtaaataaga agcatcaaag                 110


<210>  1857
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1857
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  1858
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1858
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1859
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1859
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1860
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1860
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1861
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1861
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  1862
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1862
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1863
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1863
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1864
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1864
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1865
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1865
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1866
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1866
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1867
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1867
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga gaaatccgat aaataagaag catcaaag                   108


<210>  1868
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1868
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcaggagag aaatccgata aataagaagc atcaaag                    107


<210>  1869
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1869
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  1870
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1870
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agatccgata aataagaagc atcaaag                    107


<210>  1871
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1871
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagagagc atcaaag                    107


<210>  1872
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1872
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1873
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1873
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  1874
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1874
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaatccgata aataagaagc atcaaag                    107


<210>  1875
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1875
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1876
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1876
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1877
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1877
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagag agcatcaaag                 110


<210>  1878
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1878
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagtaag catcaaag                   108


<210>  1879
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1879
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1880
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1880
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  1881
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1881
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1882
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1882
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1883
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1883
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatctcgata aataagaagc atcaaag                    107


<210>  1884
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1884
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ctatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1885
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1885
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  1886
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1886
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1887
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1887
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  1888
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1888
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  1889
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1889
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  1890
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1890
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  1891
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1891
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1892
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1892
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcagata aataagaagc atcaaag                    107


<210>  1893
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1893
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1894
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1894
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1895
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1895
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gagaaatccg ataaataaga agcatcaaag                 110


<210>  1896
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1896
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1897
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1897
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  1898
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1898
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1899
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1899
actggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1900
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1900
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  1901
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1901
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggcg agaaatccga taaataagaa gcatcaaag                  109


<210>  1902
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1902
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt agtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1903
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1903
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  1904
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1904
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1905
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1905
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atggagagaa atccgataaa taagaagcat caaag                      105


<210>  1906
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1906
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1907
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1907
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  1908
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1908
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag aggatccgat aaataagaag catcaaag                   108


<210>  1909
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1909
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1910
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1910
tactggcgct tttaatcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1911
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1911
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcgataa ataagaagca tcaaag                     106


<210>  1912
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1912
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccggat aaataagaag catcaaag                   108


<210>  1913
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1913
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1914
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1914
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt atccgataaa taagaagcat caaag                      105


<210>  1915
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1915
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgagt aaataagaag catcaaag                   108


<210>  1916
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1916
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  1917
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1917
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcccgat aaataagaag catcaaag                   108


<210>  1918
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1918
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1919
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1919
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttatta tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1920
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1920
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1921
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1921
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1922
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1922
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1923
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1923
actggcgctt ttatctgcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1924
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1924
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga gaaatccgat aaataagaag catcaaag                   108


<210>  1925
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1925
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  1926
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1926
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtaga aatccgataa ataagaagca tcaaag                     106


<210>  1927
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1927
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag aaatccgata aataagaagc atcaaag                    107


<210>  1928
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1928
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1929
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1929
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccctaa ataagaagca tcaaag                     106


<210>  1930
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1930
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1931
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1931
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1932
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1932
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1933
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1933
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaataccg ataaataaga agcatcaaag                 110


<210>  1934
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1934
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1935
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1935
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcccgataa ataagaagca tcaaag                     106


<210>  1936
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1936
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga ttatccgata aataagaagc atcaaag                    107


<210>  1937
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1937
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1938
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1938
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1939
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1939
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1940
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1940
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  1941
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1941
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1942
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1942
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1943
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1943
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggcgag aaatccgata aataagaagc atcaaag                    107


<210>  1944
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1944
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggggaaa tccgataaat aagaagcatc aaag                       104


<210>  1945
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1945
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  1946
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1946
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1947
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1947
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagta agcatcaaag                 110


<210>  1948
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1948
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1949
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1949
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  1950
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1950
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1951
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1951
tactggcgct tttaatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  1952
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1952
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgagta aataagaagc atcaaag                    107


<210>  1953
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1953
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag taaatccgat aaataagaag catcaaag                   108


<210>  1954
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1954
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggtg agaaatccga taaataagaa gcatcaaag                  109


<210>  1955
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1955
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1956
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1956
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1957
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1957
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctgagag aaatccgata aataagaagc atcaaag                    107


<210>  1958
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1958
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1959
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1959
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1960
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1960
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1961
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1961
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga tagtaagaag catcaaag                   108


<210>  1962
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1962
cctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1963
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1963
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  1964
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1964
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  1965
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1965
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1966
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1966
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1967
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1967
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  1968
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1968
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta gtcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1969
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1969
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1970
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1970
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  1971
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1971
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggtgaa atccgataaa taagaagcat caaag                      105


<210>  1972
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1972
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1973
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1973
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  1974
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1974
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  1975
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1975
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaaatccgat aaataagaag catcaaag                   108


<210>  1976
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1976
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggta gaaatccgat aaataagaag catcaaag                   108


<210>  1977
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1977
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1978
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1978
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  1979
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1979
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  1980
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1980
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1981
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1981
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  1982
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1982
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1983
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1983
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  1984
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1984
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  1985
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1985
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1986
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1986
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  1987
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1987
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  1988
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1988
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1989
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1989
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  1990
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1990
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1991
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1991
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1992
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1992
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1993
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1993
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  1994
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1994
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  1995
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1995
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  1996
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1996
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  1997
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1997
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  1998
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1998
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  1999
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  1999
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggaagaa atccgataaa taagaagcat caaag                      105


<210>  2000
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2000
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggac gaaatccgat aaataagaag catcaaag                   108


<210>  2001
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2001
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2002
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2002
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagag agcatcaaag                 110


<210>  2003
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2003
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2004
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2004
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatgcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2005
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2005
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2006
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2006
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggatga aatccgataa ataagaagca tcaaag                     106


<210>  2007
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2007
ctggcgcttt tatcctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2008
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2008
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2009
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2009
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2010
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2010
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  2011
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2011
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2012
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2012
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2013
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2013
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2014
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2014
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  2015
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2015
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga caatccgata aataagaagc atcaaag                    107


<210>  2016
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2016
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2017
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2017
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  2018
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2018
tactggcgct tttatcttat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2019
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2019
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatgccgata aataagaagc atcaaag                    107


<210>  2020
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2020
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2021
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2021
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa agcatcaaag                 110


<210>  2022
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2022
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2023
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2023
cctggcgctt ttatcatcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2024
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2024
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2025
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2025
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2026
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2026
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2027
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2027
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2028
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2028
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  2029
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2029
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt gcggagagaa atccgataaa taagaagcat caaag                      105


<210>  2030
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2030
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2031
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2031
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2032
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2032
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaatccgat aaataagaag catcaaag                   108


<210>  2033
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2033
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2034
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2034
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2035
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2035
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2036
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatacgat aaataagaag catcaaag                   108


<210>  2037
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2037
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2038
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2038
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2039
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2039
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2040
<211>  103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2040
ggcgctttta tctcattact ttgagagcca tcaccagcga ctatgtcgta tgggtaaagc       60

gcttatttat caagagaaat ccgataaata agaagcatca aag                        103


<210>  2041
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2041
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  2042
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2042
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2043
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2043
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2044
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2044
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2045
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2045
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgaat aaataagaag catcaaag                   108


<210>  2046
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2046
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccataa ataagaagca tcaaag                     106


<210>  2047
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2047
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2048
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2048
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2049
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2050
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2050
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2051
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2051
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2052
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2052
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2053
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2053
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2054
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2054
tacctggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2055
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2055
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2056
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2056
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2057
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2057
gctggcgctt ttatctcgat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2058
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2058
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgta aataagaagc atcaaag                    107


<210>  2059
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2059
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2060
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2060
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atccgtaaat aagaagcatc aaag                       104


<210>  2061
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2061
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2062
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2062
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2063
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2063
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcttgag aaatccgata aataagaagc atcaaag                    107


<210>  2064
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2064
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2065
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2065
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaaag catcaaag                   108


<210>  2066
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2066
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2067
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2067
tactggcgct tttatctttt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2068
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2068
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  2069
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2069
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2070
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2070
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2071
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2071
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcctg ataaataaga agcatcaaag                 110


<210>  2072
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2072
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2073
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2073
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag gaatccgata aataagaagc atcaaag                    107


<210>  2074
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2074
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2075
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2075
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatgccgat aaataagaag catcaaag                   108


<210>  2076
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2076
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2077
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2077
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2078
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2078
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttctcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2079
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2079
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2080
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2080
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggatg aaatccgata aataagaagc atcaaag                    107


<210>  2081
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2082
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2082
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2083
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2083
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2084
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2084
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  2085
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2085
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gaaatccgat aaataagaag catcaaag                   108


<210>  2086
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2086
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2087
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2087
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2088
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2088
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2089
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2089
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2090
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2090
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  2091
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2091
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2092
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2092
tactggccct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2093
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2093
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagat atccgataaa taagaagcat caaag                      105


<210>  2094
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2094
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2095
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2095
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaccgat aaataagaag catcaaag                   108


<210>  2096
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2096
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2097
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2097
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatatccgat aaataagaag catcaaag                   108


<210>  2098
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2098
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2099
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2099
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2100
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2100
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatagata aataagaagc atcaaag                    107


<210>  2101
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2101
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2102
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2102
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgacgcgucc ucgagcagaa gcaucaaag                              99


<210>  2103
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2103
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cgcuccguuc gagcagaagc aucaaag                                97


<210>  2104
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2104
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcccu cuucggaggg aagcaucaaa g                                      91


<210>  2105
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2105
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcagga guuucuaugg aaacccugaa gcaucaaag                              99


<210>  2106
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2106
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2107
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2107
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcg cuugcgcaga agcaucaaag                                        90


<210>  2108
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2108
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2109
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2109
uacuggcgcu uuuaucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2110
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2110
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga cuucgguccg auaaauaaga agcaucaaag                 110


<210>  2111
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2111
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcacau gaggauuacc caugugaagc aucaaag                                97


<210>  2112
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2112
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucgugaga aauccgauaa auaagaagca ucaaag                     106


<210>  2113
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2113
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugca ugucuaagac agcagaagca ucaaag                                 96


<210>  2114
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2114
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccga agcaucaaag                                        90


<210>  2115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2115
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaauc cauugcacuc cggauugaag caucaaag                               98


<210>  2116
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2116
uacuggcgcu uuucucgcau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2117
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2117
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2118
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2118
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcugcu cguuugcggc uacgagcaga agcaucaaag                            100


<210>  2119
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2119
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagag auaaauaaga agcaucaaag                            100


<210>  2120
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2120
uacggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2121
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2121
uacuggcgcc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2122
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2122
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaucggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2123
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2123
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggacu ucgguccgau aaauaagaag caucaaag                   108


<210>  2124
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2124
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgagaa auccgauaaa uaagaagcau caaag                      105


<210>  2125
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2125
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggagagaaau ccgauaaaua agaagcauca aag                        103


<210>  2126
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2126
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gagauaaaua agaagcauca aag                        103


<210>  2127
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2127
uacuggcgcu uuuaucucau uacuuuggag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag aguauccgau aaauaagaag caucaaag                   108


<210>  2128
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2128
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2129
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2129
agcgcuuuua ucucauuacu uugagagcca ucaccagcga cuaugucgua uggguaaagc       60

gcuuauuuau cggagagaaa ugccgauaaa uaagaagcau caaag                      105


<210>  2130
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2130
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaauaagaa gcaucaaag                  109


<210>  2131
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2131
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uguaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2132
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2132
gcgcuuuuau cucauuacuu ugagagccau caccagcgac uaugucguau ggguaaagcg       60

cuuauuuauc ggacuucggu ccgauaaaua agcgcaucaa ag                         102


<210>  2133
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2133
uacuggcgcu uuucucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2134
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2134
guggcgcuuu uaucucauua cuuugagagc caucaccagc gacuaugucg uauggguaaa       60

gcgcuuauuu aucggagaga aauccgauaa auaagaagca ucaaag                     106


<210>  2135
<211>  110
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2135
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaccuuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag                 110


<210>  2136
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2136
gauggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2137
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2137
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaagaagca ucaaag                     106


<210>  2138
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2138
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgaucuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2139
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2139
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aaggcuuauu uaucggagag aaauccgaua aaaagaagca ucaaag                     106


<210>  2140
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2140
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaaaagaagc aucaaag                    107


<210>  2141
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2141
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggacuu cgguccgaua aauaagaagc aucaaag                    107


<210>  2142
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2142
cggcgcuuuu cucgcauuac uuugagagcc aucaccagcg acuaugucgu auggguaaag       60

cgcuuauugu aucgagagau aaauaagaag caucaaag                               98


<210>  2143
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2143
cacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2144
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2144
uacuggcgcu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau guaucggcuu cggccgauac auaagaagca ucaaag                     106


<210>  2145
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2145
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uguaucggcu ucggccgaua cauaagaagc aucaaag                    107


<210>  2146
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2146
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggug       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2147
<211>  64
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2147
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaag                                                                    64


<210>  2148
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2148
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

ag                                                                      62


<210>  2149
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2149
gaugggcuuu uaucucauua cuuugagagc caucaccagc gacuucgguc guauggguaa       60

agcgcuuauu uaucggcuuc ggccgauaaa uaagaagcau caaag                      105


<210>  2150
<211>  156
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2150
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuaca cugggaucgc ugaauuagag aucggcgucc uuucauucua uauacuuugg      120

aguuuuaaaa ugucucuaag uacagaagca ucaaag                                156


<210>  2151
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2151
ggcgcuuuua ucucauuacu uugagagcca ucaccagcga cuucggucgu auggguaaag       60

cgcuuauuua ucggcuucgg ccgauaaaua agaagcauca aag                        103


<210>  2152
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2152
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuucggu cguaugggua       60

aagcgcuuau uuaucggcuu cggccgauaa auaagaagca ucaaag                     106


<210>  2153
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2153
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuucgg ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2154
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2154
uacuggcgcu uuuaucucau uacuuugaga gccaugcucc accagcgacu augucguaug       60

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              112


<210>  2155
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2155
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgggguu aggguuaggg uuagggaagc aucaaag                                97


<210>  2156
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2156
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcggaggg agggagggag agggaaagca ucaaag                                 96


<210>  2157
<211>  101
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2157
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcguuggg uuaggguuag gguuagggaa aagcaucaaa g                          101


<210>  2158
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2158
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggg cuucggccgg aagcaucaaa g                                      91


<210>  2159
<211>  103
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2159
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccugc ucaguacgag aggaaccgca ggaagcauca aag                        103


<210>  2160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2160
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2161
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2161
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2162
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2162
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2163
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2163
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2164
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2164
uacuggcgcc uuuaucugca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2165
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2165
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2166
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2166
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2167
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2167
uacuggcgcc uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2168
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2168
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2169
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2169
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2170
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2170
uacuggcgcc uuuaucauca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2171
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2171
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg ccggcauggu      120

cccagccucc ucgcuggcgc cggcugggca acauuccgag gggaccgucc ccucgguaau      180

ggcgaauggg accc                                                        194


<210>  2172
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2172
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcaggu gggacgaccu cucggucguc cuaucugaag caucaaag                   108


<210>  2173
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2173
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga aauccgauaa auaagaagca ucaaag                     106


<210>  2174
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2174
uacuggcgcc uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2175
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2175
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgccgga cuucgguccg gaagcaucaa ag                                     92


<210>  2176
<211>  108
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2176
uacuggcgcu uuuaucggau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   108


<210>  2177
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2177
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcggac gaccucucgg ucguccgaag caucaaag                               98


<210>  2178
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2178
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2179
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2179
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2180
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2180
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gucggcaugg      120

caucuccacc uccucgcggu ccgaccuggg cauccgaagg aggacgcacg uccacucgga      180

uggcuaaggg agagcca                                                     197


<210>  2181
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2181
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggcg caucaaag                                          88


<210>  2182
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2182
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaguu uuggccggca      120

uggucccagc cuccucgcug gcgccggcug ggcaacaugc uucggcaugg cgaaugggac      180

cccggg                                                                 186


<210>  2183
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2183
gauggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2184
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2184
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2185
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2185
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucuuacg gacuucgguc cguaagagca ucaaag                                 96


<210>  2186
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2186
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucggacg accucucggu cguccgagca ucaaag                                 96


<210>  2187
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2187
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc ugucaccgga      120

ugugcuuucc ggucugauga guccgugagg acgaaacagg                            160


<210>  2188
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2188
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2189
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2189
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2190
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2190
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucaggug ggacgaccuc ucggucgucc uaucugagca ucaaag                     106


<210>  2191
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2191
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagga uggccggcau      120

ggucccagcc uccucgcugg cgccggcugg gcaacaccuu cggguggcga augggac         177


<210>  2192
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2192
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2193
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2193
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguacugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2194
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2194
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucgugag aaauccgaua aauaagaagc aucaaag                    107


<210>  2195
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2195
guacuggcgc uuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua uuuaucggag agaaauccga uaaauaagaa gcaucaaag                  109


<210>  2196
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2196
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2197
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2197
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2198
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2198
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag                    107


<210>  2199
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2199
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2200
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2200
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2201
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2201
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2202
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2202
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2203
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2203
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugaagc aucaaag                    107


<210>  2204
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2204
uacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2205
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2205
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcccucu ucggagggaa gcaucaaag                                         89


<210>  2206
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2206
gcuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2207
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2207
gcuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcggacg accucucggu cguccgaagc aucaaag                                97


<210>  2208
<211>  177
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2208
gauggccggc auggucccag ccuccucgcu ggcgccggcu gggcaacacc uucggguggc       60

gaaugggacu acuggcgcuu uuaucucauu acuuugagag ccaucaccag cgacuauguc      120

guauggguaa agcgcuuauu uaucggagag aaauccgaua aauaagaagc aucaaag         177


<210>  2209
<211>  194
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2209
ggccggcaug gucccagccu ccucgcuggc gccggcuggg caacauuccg aggggaccgu       60

ccccucggua auggcgaaug ggacccuacu ggcgcuuuua ucucauuacu uugagagcca      120

ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau      180

aagaagcauc aaag                                                        194


<210>  2210
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2210
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagcgca ucaaag                                 96


<210>  2211
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2211
cgugguuagg gccacguuaa auaguugcuu aagcccuaag cguugaucuu cggaucaggu       60

gcaauacugg cgcuuuuauc ucauuacuuu gagagccauc accagcgacu augucguaug      120

gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa ag              172


<210>  2212
<211>  197
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2212
gggucggcau ggcaucucca ccuccucgcg guccgaccug ggcauccgaa ggaggacgca       60

cguccacucg gauggcuaag ggagagccau acuggcgcuu uuaucucauu acuuugagag      120

ccaucaccag cgacuauguc guauggguaa agcgcuuauu uaucggagag aaauccgaua      180

aauaagaagc aucaaag                                                     197


<210>  2213
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2213
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcc aguacugaug      120

aguccgugag gacgaaacga guaagcucgu cuacuggcgc uuuuaucuca u               171


<210>  2214
<211>  99
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2214
uacuggcgcc uuuaucucau uacuuuagag agccaucacc agcgacuaug ucguaugggu       60

aaagcgcuua cggacuucgg uccguaagaa gcaucaaag                              99


<210>  2215
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2215
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgu acuggcgcuu       60

uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa agcgcuuauu      120

uaucggagag aaauccgaua aauaagaagc aucaaag                               157


<210>  2216
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2216
gcuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcaggug ggacgaccuc ucggucgucc uaucugcgca ucaaag                     106


<210>  2217
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2217
uacuggcgcc uuuaucucau uacuuuagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2218
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2218
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagca uuccucagaa      120

aaugacaaac cuguggggcg uaaguagauc uucggaucua ugaucgugca gacguuaaaa      180

ucaggu                                                                 186


<210>  2219
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2219
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucgcgu guagcgaagc a               171


<210>  2220
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2220
cauuccucag aaaaugacaa accugugggg cguaaguaga ucuucggauc uaugaucgug       60

cagacguuaa aaucagguua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2221
<211>  186
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2221
uuuuggccgg caugguccca gccuccucgc uggcgccggc ugggcaacau gcuucggcau       60

ggcgaauggg accccgggua cuggcgcuuu uaucucauua cuuugagagc caucaccagc      120

gacuaugucg uauggguaaa gcgcuuauuu aucggagaga aauccgauaa auaagaagca      180

ucaaag                                                                 186


<210>  2222
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2222
cgacuacuga ugaguccgug aggacgaaac gaguaagcuc gucuagucgc guguagcgaa       60

gcauacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2223
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2223
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg gagccccgcu      120

gaugaggucg gggagaccga aagggacuuc ggucccuacg gggcuccc                   168


<210>  2224
<211>  144
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2224
ccacccccac caccaccccc acccccacca ccacccuacu ggcgcuuuua ucucauuacu       60

uugagagcca ucaccagcga cuaugucgua uggguaaagc gcuuauuuau cggagagaaa      120

uccgauaaau aagaagcauc aaag                                             144


<210>  2225
<211>  157
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2225
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg acuacugaug      120

aguccgugag gacgaaacga guaagcucgu cuagucg                               157


<210>  2226
<211>  172
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2226
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagcg ugguuagggc      120

cacguuaaau aguugcuuaa gcccuaagcg uugaucuucg gaucaggugc aa              172


<210>  2227
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2227
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaaggg caauaaagcg      120

guuacaagcc cgcaaaaaua gcagaguaau gucgcgauag cgcggcauua augcagcuuu      180

auug                                                                   184


<210>  2228
<211>  122
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2228
uacuggcgcu uuuaucucau uacuauuauc ucauuacuuu gagagccauc accagcgacu       60

augucguaug gguaaagcgc uuauuuaucg gagagaaauc cgauaaauaa gaagcaucaa      120

ag                                                                     122


<210>  2229
<211>  184
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2229
ggcaauaaag cgguuacaag cccgcaaaaa uagcagagua augucgcgau agcgcggcau       60

uaaugcagcu uuauuguacu ggcgcuuuua ucucauuacu uugagagcca ucaccagcga      120

cuaugucgua uggguaaagc gcuuauuuau cggagagaaa uccgauaaau aagaagcauc      180

aaag                                                                   184


<210>  2230
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2230
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaagac ccgcaaggcc      120

gacggcaucc gccgccgcug gugcaagucc agccgccccu ucgggggcgg gcgcucaugg      180

guaac                                                                  185


<210>  2231
<211>  63
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2231
uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aag                                                                     63


<210>  2232
<211>  168
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2232
gggagccccg cugaugaggu cggggagacc gaaagggacu ucggucccua cggggcuccc       60

uacuggcgcu uuuaucucau uacuuugaga gccaucacca gcgacuaugu cguaugggua      120

aagcgcuuau uuaucggaga gaaauccgau aaauaagaag caucaaag                   168


<210>  2233
<211>  171
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2233
ccaguacuga ugaguccgug aggacgaaac gaguaagcuc gucuacuggc gcuuuuaucu       60

cauuacuggc gcuuuuaucu cauuacuuug agagccauca ccagcgacua ugucguaugg      120

guaaagcgcu uauuuaucgg agagaaaucc gauaaauaag aagcaucaaa g               171


<210>  2234
<211>  185
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2234
acccgcaagg ccgacggcau ccgccgccgc uggugcaagu ccagccgccc cuucgggggc       60

gggcgcucau ggguaacuac uggcgcuuuu aucucauuac uuugagagcc aucaccagcg      120

acuaugucgu auggguaaag cgcuuauuua ucggagagaa auccgauaaa uaagaagcau      180

caaag                                                                  185


<210>  2235
<211>  160
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2235
ccugucaccg gaugugcuuu ccggucugau gaguccguga ggacgaaaca gguacuggcg       60

cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg uaaagcgcuu      120

auuuaucgga gagaaauccg auaaauaaga agcaucaaag                            160


<210>  2236
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2236
guacuggcgc cuuuaucuca uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag                            100


<210>  2237
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2237
guacuggcgc uuuuaucuga uuacuuugag agccaucacc agcgacuaug ucguaguggg       60

uaaagcuccc ucuucggagg gagcaucaaa g                                      91


<210>  2238
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2238
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2239
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2239
acuggcgccu uuaucucauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2240
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2240
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2241
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2241
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2242
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2242
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2243
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2243
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2244
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2244
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2245
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2245
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2246
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2246
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2247
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2247
acuggcgccu uuaucaucau uacuuugaga gccaucacca gcgacuaugu cguaugggua       60

aagcgcuuac ggacuucggu ccguaagaag caucaaag                               98


<210>  2248
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2248
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcgcccuc uucggaggga agcaucaaag                                        90


<210>  2249
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2249
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucacau gaggaucacc caugugagca ucaaag                                 96


<210>  2250
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2250
acuggcacuu uuaccugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2251
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2251
acuggcacuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2252
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2252
acuggcccuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2253
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2253
acuggcgcuu uuaccugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2254
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2254
acuggcgcuu uuaucugauu acuuugagag ccaacaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2255
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2255
acuggcaccu uuaccugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2256
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2256
acuggcaccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2257
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2257
acuggccccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2258
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2258
acuggcgccu uuaucugauu acuuugagag ccaacaccag cgacuauguc guauggguaa       60

agcgcuuacg gacuucgguc cguaagaagc aucaaag                                97


<210>  2259
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2259
gcuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2260
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2260
gacuggcgcu uuuaucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2261
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2261
acuggcgccu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2262
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2262
acuggcgcau uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2263
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2263
acuggcgccu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2264
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2264
acuggcgcuu uuaucugauu acuuuggaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2265
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2265
acuggcgcau uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2266
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2266
acuggcgcuu uuaucugauu acuuugugag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2267
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2267
acuggcgcuu uuauucugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2268
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2268
acggcgcuuu uaucugauua cuuugagagc caucaccagc gacuaugucg uaguggguaa       60

agcucccucu ucggagggag caucaaag                                          88


<210>  2269
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2269
acuggcgcuu uuauaugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2270
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2270
acuggcgcuu uuaucuugau uacuuugaga gccaucacca gcgacuaugu cguagugggu       60

aaagcucccu cuucggaggg agcaucaaag                                        90


<210>  2271
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2271
acuggcgcuu uuaucugauu acuuugagag ccagcaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2272
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2272
acuggcgcug uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2273
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2273
acuggcgcuc uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2274
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2274
acuggcgcuu guaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2275
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2275
acuggcgcuu cuaucugauu acucugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucagag                                         89


<210>  2276
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2276
acuggcgcuu ugaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2277
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2277
acuggcgcuu ucaucugauu accuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaagg                                         89


<210>  2278
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2278
acuggcgcug uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2279
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2279
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucgaag                                         89


<210>  2280
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  gNA Variant Scaffold

<400>  2280
acuggcgcuu uuaucugauu acuucgagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaag                                         89


<210>  2281
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2281
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2282
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2282
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2283
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2283
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2284
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2284
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2285
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2285
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2286
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2286
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2287
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2287
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2288
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2288
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2289
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2289
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2290
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2290
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2291
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2291
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2292
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2292
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2293
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2293
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2294
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2294
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2295
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2295
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2296
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2296
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2297
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2297
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2298
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2298
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2299
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2299
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2300
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2300
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2301
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2301
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2302
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2302
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttattcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2303
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2303
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2304
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2304
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2305
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2305
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2306
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2306
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2307
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2307
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  2308
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2308
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2309
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2309
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2310
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2310
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2311
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2311
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2312
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2312
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2313
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2313
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2314
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2314
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2315
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2315
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2316
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2316
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tagtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2317
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2317
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgtcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2318
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2318
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2319
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2319
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2320
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2320
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagctttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2321
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2321
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2322
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2322
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2323
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2323
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2324
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2324
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2325
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2325
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tataggagag aaatccgata aataagaagc atcaaag                    107


<210>  2326
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2326
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagagag catcaaag                   108


<210>  2327
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2327
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2328
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2328
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2329
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2329
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2330
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2330
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2331
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2331
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2332
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2332
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2333
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2333
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2334
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2334
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2335
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2335
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2336
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2336
tcactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcaaga gaaatccgat aaataagaag catcaaag                   108


<210>  2337
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2337
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2338
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2338
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2339
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2339
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2340
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2340
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2341
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2341
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2342
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2342
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2343
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2343
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaagagata aataagaagc atcaaag                    107


<210>  2344
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2344
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  2345
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2345
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2346
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2346
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2347
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2347
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggaa gaaatccgat aaataagaag catcaaag                   108


<210>  2348
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2348
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtattggg       60

taaagcgctt atttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2349
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2349
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2350
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2350
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2351
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2351
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2352
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2352
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2353
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2353
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag acaatccgat aaataagaag catcaaag                   108


<210>  2354
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2354
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2355
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2355
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2356
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2356
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2357
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2357
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2358
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2358
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagtaag catcaaag                   108


<210>  2359
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2359
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2360
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2360
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgaat aaataagaag catcaaag                   108


<210>  2361
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2361
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tgtatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2362
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2362
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2363
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2363
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2364
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2364
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2365
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2365
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccat aaataagaag catcaaag                   108


<210>  2366
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2366
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2367
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2367
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttagtcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2368
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2368
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccataa ataagaagca tcaaag                     106


<210>  2369
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2369
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcgcgata aataagaagc atcaaag                    107


<210>  2370
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2370
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2371
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2371
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2372
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2372
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2373
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2373
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2374
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2374
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttaatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2375
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2375
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2376
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2376
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  2377
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2377
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2378
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2378
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2379
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2379
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2380
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2380
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2381
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2381
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2382
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2382
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2383
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2383
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2384
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2384
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2385
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2385
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2386
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2386
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2387
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2387
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2388
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2388
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2389
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2389
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  2390
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2390
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2391
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2391
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaagc                   108


<210>  2392
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2392
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2393
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2393
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgaa taaataagaa gcatcaaag                  109


<210>  2394
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2394
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2395
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2395
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gatccgataa ataagaagca tcaaag                     106


<210>  2396
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2396
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2397
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2397
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2398
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2398
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2399
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2399
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2400
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2400
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2401
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2401
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2402
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2402
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg agaaatccga taaataagaa gcatcaaag                  109


<210>  2403
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2403
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2404
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2404
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatcctgat aaataagaag catcaaag                   108


<210>  2405
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2405
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2406
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2406
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2407
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2407
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2408
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2408
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2409
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2409
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2410
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2410
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagc atccgataaa taagaagcat caaag                      105


<210>  2411
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2411
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  2412
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2412
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2413
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2413
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2414
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2414
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2415
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2415
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  2416
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2416
tactggcgct tttatctgca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  2417
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2417
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2418
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2418
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2419
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2419
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2420
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2420
tactggcgct tttattcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2421
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2421
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt gtatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2422
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2422
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2423
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2423
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatctcgat aaataagaag catcaaag                   108


<210>  2424
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2424
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2425
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2425
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2426
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2426
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2427
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2427
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtagtgggt       60

aaagcgctta tttatccaga gaaatccgat aaataagaag catcaaag                   108


<210>  2428
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2428
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2429
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2429
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2430
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2430
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  2431
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2431
gctggcgctt ttaatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2432
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2432
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccta aataagaagc atcaaag                    107


<210>  2433
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2433
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt aatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2434
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2434
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2435
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2435
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtagtggg       60

taaagcgctt atttatcgga gagaaatccg ataaataagt aaagcatcaa ag              112


<210>  2436
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2436
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag agaaatccga taaataagaa gcatcaaag                  109


<210>  2437
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2437
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata gtaagaagca tcaaag                     106


<210>  2438
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2438
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2439
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2439
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2440
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2440
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2441
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2441
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2442
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2442
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2443
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2443
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2444
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2444
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2445
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2445
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  2446
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2446
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2447
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2447
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2448
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2448
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggaaag aaatccgata aataagaagc atcaaag                    107


<210>  2449
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2449
actggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2450
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2450
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2451
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2451
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2452
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2452
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2453
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2453
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2454
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2454
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2455
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2455
tcctggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2456
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2456
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2457
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2457
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2458
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2458
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2459
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2459
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2460
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2460
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2461
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2461
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagc atccgataaa taagaagcat caaag                      105


<210>  2462
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2462
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagag agcatcaaag                 110


<210>  2463
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2463
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2464
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2464
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgtattta tcggagagaa atccgataaa taagaagcat caaag                      105


<210>  2465
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2465
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2466
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2466
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2467
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2467
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2468
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2468
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2469
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2469
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2470
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2470
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2471
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2471
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2472
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2472
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagg atccgataaa taagaagcat caaag                      105


<210>  2473
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2473
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2474
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2474
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2475
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2475
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2476
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2476
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2477
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2477
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taataagaag catcaaag                   108


<210>  2478
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2478
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2479
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2479
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2480
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2480
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2481
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2481
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2482
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2482
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2483
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2483
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2484
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2484
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2485
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2485
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2486
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2486
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2487
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2487
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2488
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2488
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2489
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2489
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tcggagagaa atcacgataa ataagaagca tcaaag                     106


<210>  2490
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2490
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2491
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2491
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2492
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2492
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2493
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2493
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2494
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2494
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2495
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2495
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2496
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2496
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2497
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2497
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2498
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2498
cctgtcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2499
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2499
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga tcatccgata aataagaagc atcaaag                    107


<210>  2500
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2500
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2501
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2501
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2502
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2502
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2503
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2503
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2504
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2504
tactggcgct tttatctatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga gaaatccgat aaataagaag catcaaag                   108


<210>  2505
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2505
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2506
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2506
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2507
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2507
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2508
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2508
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2509
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2509
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2510
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2510
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatcacg ataaataaga agcatcaaag                 110


<210>  2511
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2511
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2512
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2512
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2513
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2513
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2514
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2514
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2515
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2515
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2516
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2516
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2517
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2517
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2518
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2518
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2519
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2519
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2520
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2520
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  2521
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2521
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2522
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2522
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatagat aaataagaag catcaaag                   108


<210>  2523
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2523
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgtcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2524
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2524
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2525
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2525
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2526
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2526
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2527
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2527
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatctcgat aaataagaag catcaaag                   108


<210>  2528
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2528
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2529
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2529
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2530
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2530
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctcgag aaatccgata aataagaagc atcaaag                    107


<210>  2531
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2531
ctggcgcttt tatctgcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2532
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2532
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2533
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2533
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgt ataaataaga agcatcaaag                 110


<210>  2534
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2534
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaaagata aataagaagc atcaaag                    107


<210>  2535
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2535
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2536
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2536
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  2537
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2537
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2538
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2538
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2539
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2539
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2540
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2540
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aataccgata aataagaagc atcaaag                    107


<210>  2541
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2541
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2542
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2542
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2543
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2543
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2544
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2544
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2545
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2545
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2546
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2546
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2547
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2547
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2548
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2548
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2549
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2549
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2550
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2550
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2551
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2551
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2552
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2552
tctggcgctt ttattcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2553
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2553
tactggcgct tttatcttat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2554
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2554
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2555
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2555
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag tatccgataa ataagaagca tcaaag                     106


<210>  2556
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2556
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag catccgataa ataagaagca tcaaag                     106


<210>  2557
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2557
tctggcgctt ttattctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2558
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2558
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatcgat aaataagaag catcaaag                   108


<210>  2559
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2559
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2560
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2560
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2561
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2561
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2562
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2562
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2563
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2563
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccataa ataagaagca tcaaag                     106


<210>  2564
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2564
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2565
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2565
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2566
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2566
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2567
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2567
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2568
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2568
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2569
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2569
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2570
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2570
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2571
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2571
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2572
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2572
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2573
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2573
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2574
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2574
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2575
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2575
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2576
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2576
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2577
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2577
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2578
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2578
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2579
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2579
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag aaaatccgat aaataagaag catcaaag                   108


<210>  2580
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2580
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2581
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2581
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2582
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2582
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatcacgat aaataagaag catcaaag                   108


<210>  2583
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2583
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2584
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2584
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2585
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2585
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2586
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2586
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2587
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2587
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tcttatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2588
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2588
tctggcgctt ttatctatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2589
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2589
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2590
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2590
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2591
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2591
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2592
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2592
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2593
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2593
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2594
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2594
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttactcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2595
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2595
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2596
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2596
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2597
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2597
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2598
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2598
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2599
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2599
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaatccgat aaataagaag catcaaag                   108


<210>  2600
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2600
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2601
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2601
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaatccgat aaataagaag catcaaag                   108


<210>  2602
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2602
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2603
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2603
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2604
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2604
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga tgataagaag catcaaag                   108


<210>  2605
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2605
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  2606
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2606
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2607
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2607
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2608
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2608
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag aaatccgata aataagaagc atcaaag                    107


<210>  2609
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2609
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2610
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2610
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2611
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2611
tctggcgctt ttatcatcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2612
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2612
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2613
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2613
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggtagag aaatccgata aataagaagc atcaaag                    107


<210>  2614
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2614
tactggcgct tttatcatca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2615
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2615
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2616
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2616
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2617
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2617
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2618
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2618
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2619
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2619
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  2620
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2620
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgtaa ataagaagca tcaaag                     106


<210>  2621
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2621
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgcga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2622
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2622
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2623
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2623
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2624
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2624
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatctcg ataaataaga agcatcaaag                 110


<210>  2625
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2625
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga taaataagag agcatcaaag                 110


<210>  2626
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2626
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2627
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2627
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2628
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2628
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2629
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2629
ctggcgcttt tatcccatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2630
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2630
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2631
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2631
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2632
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2632
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2633
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2633
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2634
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2634
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2635
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2635
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2636
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2636
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2637
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2637
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2638
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2638
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagac aatccgataa ataagaagca tcaaag                     106


<210>  2639
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2639
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2640
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2640
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2641
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2641
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2642
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2642
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt attcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2643
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2643
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2644
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2644
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  2645
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2645
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2646
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2646
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2647
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2647
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2648
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2648
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2649
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2649
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2650
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2650
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagaa atccgataaa taagaagcat caaag                      105


<210>  2651
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2651
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2652
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2652
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2653
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2653
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2654
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2654
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2655
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2655
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2656
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2656
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2657
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2657
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaaag catcaaag                   108


<210>  2658
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2658
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2659
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2659
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2660
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2660
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2661
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2661
gatggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2662
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2662
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctaga gaaatccgat aaataagaag catcaaag                   108


<210>  2663
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2663
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agtatccgat aaataagaag catcaaag                   108


<210>  2664
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2664
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga ataaataaga agcatcaaag                 110


<210>  2665
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2665
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2666
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2666
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcgat aaataagaag catcaaag                   108


<210>  2667
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2667
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  2668
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2668
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2669
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2669
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2670
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2670
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tataggagag aaatccgata aataagaagc atcaaag                    107


<210>  2671
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2671
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccgg taaataagaa gcatcaaag                  109


<210>  2672
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2672
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2673
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2673
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2674
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2674
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2675
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2675
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2676
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2676
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg aaatccgata aataagaagc atcaaag                    107


<210>  2677
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2677
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2678
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2678
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2679
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2679
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgaga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2680
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2680
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2681
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2681
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2682
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2682
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2683
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2683
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2684
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2684
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  2685
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2685
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  2686
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2686
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2687
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2687
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2688
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2688
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2689
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2689
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag attccgataa ataagaagca tcaaag                     106


<210>  2690
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2690
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag ggaaatccga taaataagaa gcatcaaag                  109


<210>  2691
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2691
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2692
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2692
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tgtatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2693
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2693
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2694
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2694
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2695
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2695
ttactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2696
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2696
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatc tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2697
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2697
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag aaatccgata aataagaagc atcaaag                    107


<210>  2698
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2698
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2699
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2699
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2700
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2700
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaaag catcaaag                   108


<210>  2701
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2701
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2702
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2702
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2703
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2703
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2704
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2704
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2705
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2705
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2706
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2706
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2707
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2707
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2708
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2708
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2709
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2709
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcgcg ataaataaga agcatcaaag                 110


<210>  2710
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2710
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2711
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2711
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2712
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2712
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2713
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2713
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2714
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2714
atggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga tccgataaat aagaagcatc aaag                       104


<210>  2715
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2715
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2716
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2716
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2717
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2717
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2718
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2718
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2719
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2719
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2720
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2720
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatcccg ataaataaga agcatcaaag                 110


<210>  2721
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2721
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2722
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2722
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2723
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2723
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2724
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2724
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2725
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2725
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2726
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2726
cctggcgctc ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2727
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2727
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2728
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2728
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2729
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2729
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2730
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2730
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  2731
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2731
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2732
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2732
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2733
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2733
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagagag catcaaag                   108


<210>  2734
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2734
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagt aaatccgata aataagaagc atcaaag                    107


<210>  2735
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2735
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2736
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2736
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2737
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2737
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2738
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2738
cctggcgctt ttatctcata actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2739
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2739
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2740
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2740
atactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggga gaaatccgat aaataagaag catcaaag                   108


<210>  2741
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2741
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2742
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2742
ccttgcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2743
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2743
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2744
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2744
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaagc                   108


<210>  2745
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2745
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2746
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2746
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2747
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2747
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2748
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2748
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2749
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2749
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgat aaataagaga gcatcaaag                  109


<210>  2750
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2750
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2751
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2751
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaataccga taaataagaa gcatcaaag                  109


<210>  2752
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2752
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2753
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2753
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2754
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2754
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2755
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2755
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2756
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2756
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2757
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2757
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2758
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2758
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2759
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2759
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga tgataagaag catcaaag                   108


<210>  2760
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2760
gctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2761
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2761
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga tagtaagaag catcaaag                   108


<210>  2762
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2762
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2763
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2763
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2764
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2764
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  2765
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2765
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  2766
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2766
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2767
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2767
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2768
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2768
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2769
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2769
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2770
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2770
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatcacgat aaataagaag catcaaag                   108


<210>  2771
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2771
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2772
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2772
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2773
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2773
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  2774
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2774
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgatatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2775
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2775
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2776
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2776
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaagc                   108


<210>  2777
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2777
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2778
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2778
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2779
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2779
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2780
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2780
tactggcgct tttatactca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2781
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2781
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag taaatccgat aaataagaag catcaaag                   108


<210>  2782
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2782
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggca gagaaatccg ataaataaga agcatcaaag                 110


<210>  2783
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2783
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2784
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2784
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagagt aaatccgata aataagaagc atcaaag                    107


<210>  2785
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2785
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2786
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2786
tactggcgct tttatctcga ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  2787
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2787
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt acggagagaa atccgataaa taagaagcat caaag                      105


<210>  2788
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2788
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatcgataa ataagaagca tcaaag                     106


<210>  2789
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2789
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgttag aaatccgata aataagaagc atcaaag                    107


<210>  2790
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2790
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaaacgat aaataagaag catcaaag                   108


<210>  2791
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2791
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2792
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2792
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2793
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2793
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agagaatccg ataaataaga agcatcaaag                 110


<210>  2794
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2794
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  2795
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2795
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2796
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2796
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag agaaatccga taaataagaa gcatcaaag                  109


<210>  2797
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2797
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2798
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2798
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2799
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2799
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2800
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2800
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2801
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2801
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccataa ataagaagca tcaaag                     106


<210>  2802
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2802
tactggcgct tttatctcta ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgggg aaatccgata aataagaagc atcaaag                    107


<210>  2803
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2803
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2804
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2804
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2805
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2805
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2806
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2806
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agctcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2807
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2807
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2808
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2808
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gattccgata aataagaagc atcaaag                    107


<210>  2809
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2809
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2810
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2810
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2811
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2811
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2812
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2812
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2813
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2813
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag agaaatccga taaataagaa gcatcaaag                  109


<210>  2814
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2814
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccataa ataagaagca tcaaag                     106


<210>  2815
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2815
tactggcgct tttatcctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2816
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2816
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2817
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2817
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2818
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2818
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2819
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2819
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2820
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2820
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaaacgata aataagaagc atcaaag                    107


<210>  2821
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2821
ctactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcgtga gaaatccgat aaataagaag catcaaag                   108


<210>  2822
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2822
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  2823
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2823
tactggcgct tttatcttca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttgtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2824
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2824
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2825
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2825
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagat aatccgataa ataagaagca tcaaag                     106


<210>  2826
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2826
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaaag catcaaag                   108


<210>  2827
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2827
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagagag aaatccgata aataagaagc atcaaag                    107


<210>  2828
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2828
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2829
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2829
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2830
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2830
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2831
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2831
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2832
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2832
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2833
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2833
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata gtaagaagca tcaaag                     106


<210>  2834
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2834
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2835
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2835
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2836
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2836
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2837
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2837
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2838
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2838
tctgtcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2839
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2839
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2840
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2840
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agtatccgat aaataagaag catcaaag                   108


<210>  2841
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2841
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2842
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2842
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2843
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2843
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2844
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2844
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2845
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2845
tactggcgct tttatctaca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2846
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2846
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2847
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2847
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2848
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2848
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2849
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2849
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggcaga gaaatccgat aaataagaag catcaaag                   108


<210>  2850
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2850
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2851
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2851
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2852
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2852
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2853
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2853
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2854
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2854
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  2855
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2855
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2856
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2856
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2857
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2857
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2858
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2858
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2859
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2859
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2860
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2860
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2861
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2861
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  2862
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2862
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2863
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2863
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2864
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2864
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2865
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2865
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2866
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2866
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2867
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2867
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2868
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2868
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  2869
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2869
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2870
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2870
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2871
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2871
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2872
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2872
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2873
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2873
cctggcgctt ttattcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2874
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2874
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccat aaataagaag catcaaag                   108


<210>  2875
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2875
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2876
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2876
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaagc                   108


<210>  2877
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2877
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2878
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2878
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2879
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2879
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgggagaa atccgataaa taagaagcat caaag                      105


<210>  2880
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2880
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2881
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2881
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2882
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2882
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2883
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2883
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaattcgata aataagaagc atcaaag                    107


<210>  2884
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2884
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  2885
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2885
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2886
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2886
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2887
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2887
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaaatccg ataaataaga agcatcaaag                 110


<210>  2888
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2888
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2889
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2889
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgttat ttatcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  2890
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2890
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2891
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2891
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2892
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2892
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2893
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2893
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2894
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2894
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2895
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2895
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2896
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2896
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taataagaag catcaaag                   108


<210>  2897
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2897
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2898
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2898
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2899
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2899
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2900
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2900
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2901
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2901
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  2902
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2902
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2903
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2903
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2904
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2904
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2905
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2905
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttatacgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2906
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2906
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga tagtaagaag catcaaag                   108


<210>  2907
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2907
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2908
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2908
tactggcgct tttattctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta tttatctgag agaaatccga taaataagaa gcatcaaag                  109


<210>  2909
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2909
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2910
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2910
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2911
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2911
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga ataaataaga agcatcaaag                 110


<210>  2912
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2912
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggga gagaaatccg ataaataaga agcatcaaag                 110


<210>  2913
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2913
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2914
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2914
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2915
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2915
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2916
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2916
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2917
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2917
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2918
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2918
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcggagag aaatcgcgat aaataagaag catcaaag                   108


<210>  2919
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2919
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatcgat aaataagaag catcaaag                   108


<210>  2920
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2920
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2921
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2921
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt ttcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2922
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2922
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2923
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2923
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  2924
<211>  105
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2924
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcgagagaa atccgataaa taagaagcat caaag                      105


<210>  2925
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2925
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2926
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2926
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  2927
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2927
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2928
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2928
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagag agcatcaaag                 110


<210>  2929
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2929
tactggcgct tttatctcat tactttgaga gccatcaaca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2930
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2930
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatagggag aaatccgata aataagaagc atcaaag                    107


<210>  2931
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2931
tactggcgct tttatcccat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2932
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2932
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccat aaataagaag catcaaag                   108


<210>  2933
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2933
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatcccgat aaataagaag catcaaag                   108


<210>  2934
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2934
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2935
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2935
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2936
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2936
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgaagag aaatccgata aataagaagc atcaaag                    107


<210>  2937
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2937
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2938
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2938
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2939
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2939
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  2940
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2940
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2941
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2941
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2942
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2942
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2943
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2943
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  2944
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2944
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2945
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2945
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  2946
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2946
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattgggt       60

aaagcgctta tttattgaga gaaatccgat aaataagaag catcaaag                   108


<210>  2947
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2947
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  2948
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2948
cactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  2949
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2949
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatcccgata aataagaagc atcaaag                    107


<210>  2950
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2950
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2951
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2951
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2952
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2952
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatctagaga aatccgataa ataagaagca tcaaag                     106


<210>  2953
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2953
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgcat aaataagaag catcaaag                   108


<210>  2954
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2954
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2955
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2955
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  2956
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2956
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2957
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2957
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatccat aaataagaag catcaaag                   108


<210>  2958
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2958
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2959
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2959
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2960
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2960
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2961
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2961
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag gaatccgata aataagaagc atcaaag                    107


<210>  2962
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2962
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2963
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2963
cctggcgctt ttatcccatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2964
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2964
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcacga taaataagaa gcatcaaag                  109


<210>  2965
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2965
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2966
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2966
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2967
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2967
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2968
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2968
tggcgctttt atctcattac tttgagagcc atcaccagcg actatgtcgt atgggtaaag       60

cgcttattta tctggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2969
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2969
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2970
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2970
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatccagaga aatccgataa ataagaagca tcaaag                     106


<210>  2971
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2971
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2972
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2972
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  2973
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2973
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  2974
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2974
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2975
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2975
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2976
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2976
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtag aaatccgata aataagaagc atcaaag                    107


<210>  2977
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2977
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2978
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2978
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  2979
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2979
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatcccgat aaataagaag catcaaag                   108


<210>  2980
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2980
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagga aatccgataa ataagaagca tcaaag                     106


<210>  2981
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2981
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  2982
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2982
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2983
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2983
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2984
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2984
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2985
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2985
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2986
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2986
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcacttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2987
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2987
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2988
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2988
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2989
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2989
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2990
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2990
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2991
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2991
tacggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  2992
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2992
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcctga taaataagaa gcatcaaag                  109


<210>  2993
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2993
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  2994
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2994
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  2995
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2995
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttactcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  2996
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2996
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2997
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2997
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  2998
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2998
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  2999
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  2999
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3000
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3000
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3001
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3001
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3002
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3002
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccat aaataagaag catcaaag                   108


<210>  3003
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3003
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggaaga aatccgataa ataagaagca tcaaag                     106


<210>  3004
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3004
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3005
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3005
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  3006
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3006
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3007
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3007
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3008
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3008
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3009
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3009
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3010
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3010
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3011
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3011
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatgccg ataaataaga agcatcaaag                 110


<210>  3012
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3012
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  3013
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3013
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3014
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3014
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3015
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3015
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3016
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3016
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag ggaaatccga taaataagaa gcatcaaag                  109


<210>  3017
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3017
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3018
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3018
cctggcgctt ttatctaatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3019
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3019
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatcgat aaataagaag catcaaag                   108


<210>  3020
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3020
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3021
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3021
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatccgata aataagaagc atcaaag                    107


<210>  3022
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3022
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3023
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3023
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3024
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3024
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3025
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3025
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3026
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3026
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  3027
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3027
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3028
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3028
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3029
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3029
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3030
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3030
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3031
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3031
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  3032
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3032
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3033
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3033
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  3034
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3034
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag aggatccgat aaataagaag catcaaag                   108


<210>  3035
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3035
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3036
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3036
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3037
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3037
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3038
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3038
tactggcgct tttatttcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  3039
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3039
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3040
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3040
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3041
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3041
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  3042
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3042
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3043
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3043
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3044
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3044
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  3045
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3045
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt agtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3046
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3046
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3047
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3047
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgcgag aaatccgata aataagaagc atcaaag                    107


<210>  3048
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3048
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3049
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3049
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3050
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3050
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gatccgataa ataagaagca tcaaag                     106


<210>  3051
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3051
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3052
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3052
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3053
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3053
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3054
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3054
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3055
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3055
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3056
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3056
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3057
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3057
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3058
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3058
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3059
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3059
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaatccgat aaataagaag catcaaag                   108


<210>  3060
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3060
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaagc                   108


<210>  3061
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3061
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcaagaga aatccgataa ataagaagca tcaaag                     106


<210>  3062
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3062
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattaggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3063
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3063
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3064
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3064
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3065
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3065
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3066
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3066
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3067
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3067
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3068
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3068
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3069
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3069
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3070
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3070
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3071
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3071
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3072
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3072
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccagag aaatccgata aataagaagc atcaaag                    107


<210>  3073
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3073
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tattcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3074
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3074
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3075
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3075
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3076
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3076
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggtga gaaatccgat aaataagaag catcaaag                   108


<210>  3077
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3077
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3078
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3078
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  3079
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3079
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3080
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3080
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3081
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3081
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3082
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3082
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  3083
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3083
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3084
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3084
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3085
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3085
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3086
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3086
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcccga taaataagaa gcatcaaag                  109


<210>  3087
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3087
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3088
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3088
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3089
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3089
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3090
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3090
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3091
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3091
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaagc                 110


<210>  3092
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3092
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3093
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3093
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3094
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3094
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3095
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3095
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3096
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3096
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag gaaatccgat aaataagaag catcaaag                   108


<210>  3097
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3097
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tgcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3098
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3098
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aatccgataa ataagaagca tcaaag                     106


<210>  3099
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3099
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3100
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3100
tactggcgcc tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatctcga taaataagaa gcatcaaag                  109


<210>  3101
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3101
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaagc                   108


<210>  3102
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3102
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3103
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3103
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aatccgataa ataagaagca tcaaag                     106


<210>  3104
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3104
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3105
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3105
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3106
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3106
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3107
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3107
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3108
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3108
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3109
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3109
catggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3110
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3110
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatacggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3111
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3111
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agtatccgat aaataagaag catcaaag                   108


<210>  3112
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3112
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3113
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3113
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3114
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3114
cctggcgctt ttatctcatt actttgagag caatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3115
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3115
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag gaatccgata aataagaagc atcaaag                    107


<210>  3116
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3116
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3117
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3117
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3118
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3118
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  3119
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3119
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3120
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3120
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3121
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3121
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3122
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3122
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3123
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3123
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3124
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3124
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3125
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3125
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tacggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3126
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3126
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggga gaaatccgat aaataagaag catcaaag                   108


<210>  3127
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3127
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3128
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3128
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga aatccgataa ataagaagca tcaaag                     106


<210>  3129
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3129
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3130
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3130
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3131
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3131
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatgccga taaataagaa gcatcaaag                  109


<210>  3132
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3132
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatgcggag aggaatccga taaataagaa gcatcaaag                  109


<210>  3133
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3133
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3134
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3134
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgaggg aaatccgata aataagaagc atcaaag                    107


<210>  3135
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3135
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcgggaga aatccgataa ataagaagca tcaaag                     106


<210>  3136
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3136
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatatagag aaatccgata aataagaagc atcaaag                    107


<210>  3137
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3137
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3138
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3138
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3139
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3139
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3140
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3140
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcctgag agaaatccga taaataagaa gcatcaaag                  109


<210>  3141
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3141
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3142
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3142
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3143
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3143
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3144
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3144
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc ataaaag                    107


<210>  3145
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3145
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3146
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3146
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3147
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3147
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  3148
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3148
taactggcgc ttttatctca ttactttgag agccatcacc agcgactatg tcgtatgggt       60

aaagcgctta ttctatcgga gagaaatccg ataaataaga agcatcaaag                 110


<210>  3149
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3149
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3150
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3150
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3151
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3151
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3152
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3152
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatggagag aaatcgataa ataagaagca tcaaag                     106


<210>  3153
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3153
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3154
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3154
cctggcgctt ttatcttatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3155
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3155
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3156
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3156
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3157
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3157
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3158
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3158
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3159
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3159
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3160
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3160
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3161
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3161
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3162
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3162
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3163
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3163
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3164
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3164
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3165
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3165
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3166
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3166
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3167
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3167
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagccttatt tatcgagaga aatccgataa ataagaagca tcaaag                     106


<210>  3168
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3168
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagctcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3169
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3169
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3170
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3170
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tctatcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3171
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3171
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttaccgagag aaatccgata aataagaagc atcaaag                    107


<210>  3172
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3172
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3173
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3173
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3174
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3174
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3175
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3175
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3176
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3176
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3177
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3177
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3178
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3178
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3179
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3179
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3180
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3180
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3181
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3181
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3182
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3182
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3183
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3183
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3184
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3184
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccgata aataagaagc atcaaag                    107


<210>  3185
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3185
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatcagata aataagaagc atcaaag                    107


<210>  3186
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3186
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tatatcggag agaatccgat aaataagaag catcaaag                   108


<210>  3187
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3187
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3188
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3188
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccataa ataagaagca tcaaag                     106


<210>  3189
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3189
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag aaatccataa ataagaagca tcaaag                     106


<210>  3190
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3190
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3191
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3191
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3192
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3192
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatacgata aataagaagc atcaaag                    107


<210>  3193
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3193
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcggtattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3194
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3194
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3195
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3195
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3196
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3196
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3197
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3197
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3198
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3198
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3199
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3199
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3200
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3200
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3201
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3201
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3202
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3202
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccgc ataaataaga agcatcaaag                 110


<210>  3203
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3203
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatacggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3204
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3204
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3205
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3205
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3206
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3206
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3207
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3207
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3208
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3208
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3209
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3209
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3210
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3210
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3211
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3211
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaaga atcaaag                    107


<210>  3212
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3212
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3213
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3213
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3214
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3214
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtattggta       60

aagcgcttat ttatgcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3215
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3215
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3216
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3216
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3217
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3217
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3218
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3218
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3219
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3219
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3220
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3220
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3221
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3221
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatctcgat aaataagaag catcaaag                   108


<210>  3222
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3222
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3223
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3223
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3224
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3224
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttgcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3225
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3225
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaagc                   108


<210>  3226
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3226
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatggttaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3227
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3227
ctggcgcttt tatctcatta ctttgagagc catcaccagc gactatgtcg tatgggtaaa       60

gcgcttattt atcggagaga aatccgataa ataagaagca tcaaag                     106


<210>  3228
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3228
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3229
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3229
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3230
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3230
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3231
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3231
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3232
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3232
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3233
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3233
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3234
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3234
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3235
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3235
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3236
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3236
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3237
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3237
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3238
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3238
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3239
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3239
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3240
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3240
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccata aataagaagc atcaaag                    107


<210>  3241
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3241
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3242
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3242
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3243
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3243
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3244
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3244
tctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3245
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3245
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3246
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3246
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3247
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3247
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3248
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3248
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga taatccgata aataagaagc atcaaag                    107


<210>  3249
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3249
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgtgag aaatccgata aataagaagc atcaaag                    107


<210>  3250
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3250
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3251
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3251
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3252
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3252
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgata aataagaagc atcaaag                    107


<210>  3253
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3253
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3254
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3254
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatccgca taaataagaa gcatcaaag                  109


<210>  3255
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3255
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggagg aaatccgata aataagaagc atcaaag                    107


<210>  3256
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3256
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3257
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3257
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3258
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3258
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3259
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3259
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3260
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3260
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3261
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3261
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3262
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3262
cctggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3263
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3263
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatgcggaga gaaatccgat aaataagaag catcaaag                   108


<210>  3264
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3264
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctggag aaatccgata aataagaagc atcaaag                    107


<210>  3265
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3265
tactggcgct tttatctcat tactttgaga gccataacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcaagag aaatccgata aataagaagc atcaaag                    107


<210>  3266
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3266
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3267
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3267
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttacggagag aaatccgcat aaataagaag catcaaag                   108


<210>  3268
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3268
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag agaaatccga taaataagaa gcatcaaag                  109


<210>  3269
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3269
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3270
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3270
tactggctct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3271
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3271
actggcgctt ttatctcatt actttgagag ccatcaccag cgactatgtc gtatgggtaa       60

agcgcttatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3272
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3272
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttataggaga gaaatcgcga taaataagaa gcatcaaag                  109


<210>  3273
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3273
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gtatccgata aataagaagc atcaaag                    107


<210>  3274
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3274
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttagtcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3275
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3275
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3276
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3276
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattgagag aaatccgata aataagaagc atcaaag                    107


<210>  3277
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3277
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3278
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3278
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3279
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3279
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3280
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3280
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3281
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3281
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3282
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3282
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatccggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3283
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3283
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggcag agaaatccga taaataagaa gcatcaaag                  109


<210>  3284
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3284
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt agtatgggta       60

aagcgcttat ttatcgagag aaatccgata aataagaagc atcaaag                    107


<210>  3285
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3285
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaag aaatccgata aataagaagc atcaaag                    107


<210>  3286
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3286
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3287
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3287
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3288
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3288
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3289
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3289
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat tttcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3290
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3290
tactggcgct tttatctaat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3291
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3291
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcggtatt tatcggagag aaatccgata aataagaagc atcaaag                    107


<210>  3292
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3292
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggggg aaatccgata aataagaagc atcaaag                    107


<210>  3293
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3293
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatctagag aaatccgata aataagaagc atcaaag                    107


<210>  3294
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3294
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttatcggaga gaaatcgata aataagaagc atcaaag                    107


<210>  3295
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scaffold variant

<400>  3295
tactggcgct tttatctcat tactttgaga gccatcacca gcgactatgt cgtatgggta       60

aagcgcttat ttattcggag agaaatccga taaataagaa gcatcaaag                  109


<210>  3296
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  3296
nnttcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  3297
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  3297
nnctcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  3298
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GTC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  3298
nngtcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  3299
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  3299
nnatcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  3300
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TC protospacer adjacent motif


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(47)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (21)..(42)
<223>  These individual nucleotides may be absent

<400>  3300
nnntcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnn                     47


<210>  3301
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3301

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3302
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3302

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Ala Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3303
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3303

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3304
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3304

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Gln Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3305
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3305

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Gln Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3306
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3306

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Ile Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3307
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3307

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3308
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3308

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3309
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3309

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3310
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3310

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3311
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3311

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Lys Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3312
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3312

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3313
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3313

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3314
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3314

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3315
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3315

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3316
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3316

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3317
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3317

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Asp Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3318
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3318

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Phe Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3319
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3319

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3320
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3320

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3321
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3321

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3322
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3322

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Ile Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Asn Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3323
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3323

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Lys Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3324
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3324

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3325
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3325

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Met Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3326
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3326

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3327
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3327

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Arg Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3328
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3328

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3329
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3329

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3330
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3330

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Ala Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3331
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3331

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3332
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3332

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3333
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3333

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Gly Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3334
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3334

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3335
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3335

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Lys Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3336
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3336

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Asn Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3337
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3337

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Ala Ser Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3338
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3338

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe His Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3339
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3339

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3340
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3340

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Trp Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3341
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3341

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3342
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3342

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3343
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3343

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Met Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3344
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3344

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3345
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3345

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Pro Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3346
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3346

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Gln Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3347
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3347

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Lys Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3348
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3348

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3349
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3349

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Gln Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3350
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3350

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Ala Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3351
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3351

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3352
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3352

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Leu Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3353
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3353

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3354
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3354

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Thr Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3355
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3355

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Gln Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3356
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3356

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3357
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3357

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Ser Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3358
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3358

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Ser Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3359
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3359

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Lys Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3360
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3360

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Asn Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3361
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3361

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3362
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3362

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Arg Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3363
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3363

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3364
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3364

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Arg Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3365
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3365

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Glu 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3366
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3366

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3367
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3367

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Lys Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3368
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3368

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile His Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3369
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3369

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Lys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Thr Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3370
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3370

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Arg Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3371
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3371

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Lys Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3372
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3372

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Arg Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3373
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3373

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Arg Pro 
                965                 970                 975     


Ala Val 
        


<210>  3374
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3374

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Met Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3375
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3375

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Ser Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3376
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3376

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Ser Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3377
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3377

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Thr Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3378
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3378

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Gln Pro 
                965                 970                 975     


Ala Val 
        


<210>  3379
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3379

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Arg Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3380
<211>  977
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3380

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210>  3381
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3381

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Trp Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3382
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3382

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3383
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3383

Met Gln Glu Ile Lys Arg Phe Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3384
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3384

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Lys Ile Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3385
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3385

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Glu Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3386
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3386

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Ala Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3387
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3387

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3388
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3388

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Gln Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3389
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3389

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asn Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3390
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3390

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Lys Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3391
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3391

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Arg Lys Thr Leu Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3392
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3392

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3393
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3393

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Lys Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3394
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3394

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Pro Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3395
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3395

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Gly Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3396
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3396

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Leu Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3397
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3397

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Lys Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3398
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3398

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Arg Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3399
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3399

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Lys Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3400
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3400

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Lys Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3401
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3401

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Gln Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3402
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3402

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asn Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3403
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3403

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Arg Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3404
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3404

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile His Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3405
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3405

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Lys Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3406
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3406

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Glu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3407
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3407

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Arg Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3408
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3408

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro Asp Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3409
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3409

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Gly Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3410
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3410

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Pro Pro Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3411
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3411

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Phe Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3412
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3412

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Met Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3413
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3413

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Arg Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3414
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3414

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Arg Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3415
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3415

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Gly Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3416
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3416

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Val Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3417
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3417

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Gly 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3418
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3418

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Glu Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3419
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3419

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Lys Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3420
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3420

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Gln Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3421
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3421

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Phe Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3422
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3422

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Gln Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3423
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3423

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Lys Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3424
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3424

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Ala Ser Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3425
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3425

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Glu Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3426
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3426

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Ala Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3427
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3427

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Glu Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3428
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3428

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Gln Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3429
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3429

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Ala Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3430
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3430

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Gln Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3431
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3431

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Lys Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3432
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3432

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Ile Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3433
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3433

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asp 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3434
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3434

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Met Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3435
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3435

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Ser Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3436
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3436

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Lys Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ser Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3437
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3437

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Ile Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3438
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3438

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Gln Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3439
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3439

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asp Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3440
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3440

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Met Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3441
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3441

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Asp Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3442
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3442

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Leu Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3443
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3443

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ala Ser Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3444
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3444

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Ser Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3445
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3445

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Trp Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3446
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3446

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ser Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3447
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3447

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Arg Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3448
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3448

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Lys Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3449
<211>  980
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3449

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Ala Ser Lys Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
                805                 810                 815     


Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys 
            820                 825                 830         


Lys Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys 
        835                 840                 845             


Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val 
    850                 855                 860                 


Val Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val 
865                 870                 875                 880 


Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu 
                885                 890                 895     


Ser Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe 
            900                 905                 910         


Val Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala 
        915                 920                 925             


Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys 
    930                 935                 940                 


Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe 
945                 950                 955                 960 


Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp 
                965                 970                 975     


Lys Pro Ala Val 
            980 


<210>  3450
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3450

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Tyr Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3451
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3451

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Arg Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3452
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3452

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Asp Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3453
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3453

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Glu 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3454
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3454

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Ile Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3455
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3455

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Arg Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3456
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3456

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Pro Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3457
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3457

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Leu Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3458
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3458

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Asp Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3459
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3459

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Lys 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3460
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3460

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Arg Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3461
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3461

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Lys 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3462
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3462

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Val Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3463
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3463

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Glu Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3464
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3464

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Thr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3465
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3465

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Ser Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3466
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3466

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Glu Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3467
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3467

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Thr Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3468
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3468

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asn Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3469
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3469

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Phe His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3470
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3470

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Ser Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3471
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3471

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Ala Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3472
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3472

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Asn Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3473
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3473

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Arg Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3474
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3474

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Pro Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3475
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3475

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Ile Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3476
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3476

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Thr Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3477
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3477

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Gly Arg Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3478
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3478

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Asn Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3479
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3479

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Pro Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3480
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3480

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Arg Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3481
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3481

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Gly Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3482
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3482

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Met Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser 
785                 790                 795                 800 


Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe 
                805                 810                 815     


Thr Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys 
            820                 825                 830         


Thr Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val 
        835                 840                 845             


Glu Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val 
    850                 855                 860                 


Lys Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn 
865                 870                 875                 880 


Asn Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser 
                885                 890                 895     


Leu Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val 
            900                 905                 910         


Cys Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu 
        915                 920                 925             


Asn Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys 
    930                 935                 940                 


Tyr Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val 
945                 950                 955                 960 


Glu Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys 
                965                 970                 975     


Pro Ala Val 
            


<210>  3483
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3483

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys Arg Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3484
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3484

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ser Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3485
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3485

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Lys 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3486
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3486

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Asn Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3487
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3487

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu Arg Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3488
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3488

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Ile Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Ala Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Asp Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ser Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Pro Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3489
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3489

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile His Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3490
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3490

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Val Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3491
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3491

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Asp Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3492
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3492

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Ala Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3493
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX Protein Variant

<400>  3493

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Pro Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  3494
<211>  3120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct WT Cas X sequence of SEQ ID NO: 2 fused to an N 
       terminal NLS

<400>  3494
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcttccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcagc caaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgccgtcta aaacttacct gagcaagacc ctggctcagt acaccagtaa aacctgtagt     2460

aattgcggct ttaccatcac cagcgccgat tatgaccgcg tgctggaaaa gctgaagaaa     2520

accgccaccg gctggatgac caccatcaat ggtaaagagc ttaaagtcga agggcagatt     2580

acttattaca accgttataa gcggcaaaac gtggtgaaag atctgtcggt tgagctggac     2640

cgtttgtctg aagaaagcgt gaacaatgat atcagctcct ggaccaaagg tcgttccggc     2700

gaagcgttaa gtctgttgaa aaagcgcttt agccatcgcc cggtgcagga aaaattcgtt     2760

tgcctgaact gtggcttcga aacccacgcc gacgagcaag cggcgctcaa tattgcgcgt     2820

agctggctgt tcctgcgcag ccaggaatat aaaaaatatc aaaccaacaa aacaactggc     2880

aataccgaca agcgtgcctt tgttgaaacc tggcagagct tctatcgcaa aaaactgaaa     2940

gaggtctgga aaccggcggt agcgccaaag aaaaaacgca aagtgagcga aaatctttat     3000

tttcaaggta gcgcatggag tcatcctcaa ttcgagaaag gtggaggttc tggcggtgga     3060

tcgggaggtt cagcgtggag ccacccgcag ttcgaaaaag gaaggggatc cggctgctaa     3120


<210>  3495
<211>  3123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 119

<400>  3495
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcgtccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gtttggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtat tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcaaa gaaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgtctaaaa cttacctgag caagaccctg gctcagtaca ccagtaaaac ctgtagtaat     2460

tgcggcttta ccatcaccag cgccgattat gaccgcgtgc tggaaaagct gaagaaaacc     2520

gccaccggct ggatgaccac catcaatggt aaagagctta aagtcgaagg gcagattact     2580

tattacaacc gttataagcg gcaaaacgtg gtgaaagatc tgtcggttga gctggaccgt     2640

ttgtctgaag aaagcgtgaa caatgatatc agctcctgga ccaaaggtcg ttccggcgaa     2700

gcgttaagtc tgttgaaaaa gcgctttagc catcgcccgg tgcaggaaaa attcgtttgc     2760

ctgaactgtg gcttcgaaac ccacgccgac gagcaagcgg cgctcaatat tgcgcgtagc     2820

tggctgttcc tgcgcagcca ggaatataaa aaatatcaaa ccaacaaaac aactggcaat     2880

accgacaagc gtgcctttgt tgaaacctgg cagagcttct atcgcaagaa gctgaaagag     2940

gtctggaaac cggcggtacc acctgcgcca aagaaaaaac gcaaagtgag cgaaaatctt     3000

tattttcaag gtagcgcatg gagtcatcct caattcgaga aaggtggagg ttctggcggt     3060

ggatcgggag gttcagcgtg gagccacccg cagttcgaaa aaggaagggg atccggctgc     3120

taa                                                                   3123


<210>  3496
<211>  3123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 438

<400>  3496
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

cagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcgtccgtat ctctcttcag aagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gttgggcgat ttattaaagc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaacgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtgt tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcaaa gaaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgtctaaaa cttacctgag caagaccctg gctcagtaca ccagtaaaac ctgtagtaat     2460

tgcggcttta ccatcaccag cgccgattat gaccgcgtgc tggaaaagct gaagaaaacc     2520

gccaccggct ggatgaccac catcaatggt aaagagctta aagtcgaagg gcagattact     2580

tattacaacc gtcgtaagcg gcaaaacgtg gtgaaagatc tgtcggttga gctggaccgt     2640

ttgtctgaag aaagcgtgaa caatgatatc agctcctgga ccaaaggtcg ttccggcgaa     2700

gcgttaagtc tgttgaaaaa gcgctttagc catcgcccgg tgcaggaaaa attcgtttgc     2760

ctgaactgtg gcttcgaaac ccacgccgac gagcaagcgg cgctcaatat tgcgcgtagc     2820

tggctgttcc tgcgcagcca ggaatataaa aaatatcaaa ccaacaaaac aactggcaat     2880

accgacaagc gtgcctttgt tgaaacctgg cagagcttct atcgcaagaa gctgaaagag     2940

gtctggaaac cggcggtacc acctgcgcca aagaaaaaac gcaaagtgag cgaaaatctt     3000

tattttcaag gtagcgcatg gagtcatcct caattcgaga aaggtggagg ttctggcggt     3060

ggatcgggag gttcagcgtg gagccacccg cagttcgaaa aaggaagggg atccggctgc     3120

taa                                                                   3123


<210>  3497
<211>  3123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 457

<400>  3497
atggctccga agaagaagcg aaaggtcagc caggaaatta aacgcatcaa caagatccgc       60

cgtcgtctgg taaaagacag caatacgaaa aaagccggaa aaaccggtcc gatgaaaacg      120

ctgctggtgc gcgtgatgac gccggatctc cgcgaacgtc ttgagaattt gcgtaagaaa      180

cctgaaaata ttccgcaacc gatttctaac acctcgcgcg ccaatctgaa taaactgctg      240

accgattaca ccgaaatgaa gaaagcgatt ctgcacgttt actgggaaga gttccagaaa      300

gacccggtcg gtctgatgag ccgcgttgcg caacctgcgc cgaaaaatat cgatcagcgc      360

aagttaatcc cggttaaaga tggtaatgaa cgtttaacct ccagcggctt tgcctgcagt      420

cagtgctgcc agccacttta tgtttataaa cttgaacagg ttaacgataa agggaaaccc      480

cataccaatt atttcggccg ctgcaatgtc agcgaacatg aacgcctgat tttgttaagc      540

ccgcataaac cggaagcgaa tgacgaactg gtgacctatt ccctgggtaa atttggtcag      600

cgggcgctgg atttttacag cattcatgtg acgcgggaaa gtaaccatcc ggtaaagcca      660

ctggaacaaa tcggcggtaa cagctgcgcc tctggcccgg ttggcaaagc gcttagcgat      720

gcctgtatgg gcgcggtggc gagctttctg acaaaatacc aggatattat cctggagcat      780

aagaaggtga tcaaaaagaa cgagaaacgt ctggcaaatt taaaggatat tgcctccgct      840

aacggcctgg cgttcccgaa gattacctta ccgccgcagc cgcacaccaa agaaggtatc      900

gaagcgtata acaacgttgt tgcccagatc gtcatctggg tgaatctcaa cctgtggcaa      960

aaactgaaaa ttggtcgtga tgaagcaaaa ccgttgcagc gactgaaagg attcccgtcg     1020

tttccgctgg ttgaacgaca ggcgaacgaa gtggattggt gggatatggt ttgtaacgtc     1080

aaaaaattga tcaacgaaaa aaaggaagat ggcaaagttt tctggcaaaa tctggcgggt     1140

tacaaacgtc aggaggcgtt gcgtccgtat ctctcttcac cagaagatcg caaaaaaggc     1200

aagaagtttg ctcgctatca gttgggcgat ttattactgc atctggaaaa aaaacacggc     1260

gaagactggg gcaaagtgta cgatgaagcc tgggagcgta tcgacaaaaa agtggaaggt     1320

ttgtcgaaac atattaaact cgaagaagag cgccgcagtg aagatgcgca gtcaaaagca     1380

gcgctgacgg actggttacg tgcgaaagcc agttttgtga ttgaaggatt aaaagaagct     1440

gataaagatg aattttgccg ttgcgaactg aaactgcaaa aatggtatgg cgacctgcgc     1500

ggcaaaccgt tcgccattga ggcagaaaat agcatccttg atatctccgg tttcagcaaa     1560

caatataact gcgcgtttat ttggcagaaa gacggcgtga aaaagcttaa cctgtatctg     1620

atcattaact attttaaagg cgggaaactg cgtttcaaga aaatcaagcc ggaagcattt     1680

gaagccaatc gtttttatac cgttattaat aaaaaaagcg gtgaaatcgt gccgatggaa     1740

gttaatttta actttgatga tccgaacttg attattctgc cgctggcatt cggtaaacgg     1800

cagggccgtg agtttatctg gaacgacctg ttatcgctgg aaacgggcag cctgaaatta     1860

gccaacggtc gcgtcattga aaaaccgctc tacaaccgcc gcacccgcca ggatgagccg     1920

gcactgtttg tcgcgctgac ctttgaacgg cgtgaagtcc tcgatagcag caacatcaaa     1980

ccaatgaacc ttatcggtgt tgatcgtggt gaaaacattc ctgccgttat cgccctgact     2040

gatccagaag gctgcccgct ttctcgcttc aaagattcac tgggcaaccc gacccatatc     2100

ctccgtattg gcgagagcta caaagagaaa cagcgtacca ttcaggcaaa gaaagaagtg     2160

gagcagcgtc gcgcgggcgg ctatagccgt aaatatgcca gcaaagctaa aaacctggcg     2220

gatgacatgg tgcgtaacac ggcgcgcgat ttgctgtact acgccgtcac ccaggacgcg     2280

atgctgattt ttgagaacct ctcccgcggt tttgggcgtc agggtaaacg cacgtttatg     2340

gcggaacgcc agtatacgcg tatggaggac tggctgaccg cgaagctggc ctatgaaggc     2400

ttgtctaaaa cttacctgag caagaccctg gctcagtaca ccagtaaaac ctgtagtaat     2460

tgcggcttta ccatcaccag cgccgattat gaccgcgtgc tggaaaagct gaagaaaacc     2520

gccaccggct ggatgaccac catcaatggt aaagagctta aagtcgaagg gcagattact     2580

tattacaacc gtcgtaagcg gcaaaacgtg gtgaaagatc tgtcggttga gctggaccgt     2640

ttgtctgaag aaagcgtgaa caatgatatc agctcctgga ccaaaggtcg ttccggcgaa     2700

gcgttaagtc tgttgaaaaa gcgctttagc catcgcccgg tgcaggaaaa attcgtttgc     2760

ctgaactgtg gcttcgaaac ccacgccgac gagcaagcgg cgctcaatat tgcgcgtagc     2820

tggctgttcc tgcgcagcca ggaatataaa aaatatcaaa ccaacaaaac aactggcaat     2880

accgacaagc gtgcctttgt tgaaacctgg cagagcttct atcgcaagaa gctgaaagag     2940

gtctggaaac cggcggtacc acctgcgcca aagaaaaaac gcaaagtgag cgaaaatctt     3000

tattttcaag gtagcgcatg gagtcatcct caattcgaga aaggtggagg ttctggcggt     3060

ggatcgggag gttcagcgtg gagccacccg cagttcgaaa aaggaagggg atccggctgc     3120

taa                                                                   3123


<210>  3498
<211>  1039
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct WT Cas X sequence of SEQ ID NO: 2 fused to an N 
       terminal NLS

<400>  3498

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Gln Glu Ile Lys Arg Ile 
1               5                   10                  15      


Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys Ala 
            20                  25                  30          


Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr Pro 
        35                  40                  45              


Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn Ile 
    50                  55                  60                  


Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu 
65                  70                  75                  80  


Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu 
                85                  90                  95      


Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro 
            100                 105                 110         


Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly 
        115                 120                 125             


Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln 
    130                 135                 140                 


Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro 
145                 150                 155                 160 


His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu 
                165                 170                 175     


Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr 
            180                 185                 190         


Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile 
        195                 200                 205             


His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile 
    210                 215                 220                 


Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp 
225                 230                 235                 240 


Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile 
                245                 250                 255     


Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala 
            260                 265                 270         


Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile 
        275                 280                 285             


Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn 
    290                 295                 300                 


Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln 
305                 310                 315                 320 


Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys 
                325                 330                 335     


Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp 
            340                 345                 350         


Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys 
        355                 360                 365             


Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln 
    370                 375                 380                 


Glu Ala Leu Leu Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly 
385                 390                 395                 400 


Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu 
                405                 410                 415     


Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu 
        435                 440                 445             


Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala 
465                 470                 475                 480 


Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Ala Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Ala Pro Lys Lys Lys 
            980                 985                 990         


Arg Lys Val Ser Glu Asn Leu Tyr  Phe Gln Gly Ser Ala  Trp Ser His 
        995                 1000                 1005             


Pro Gln  Phe Glu Lys Gly Gly  Gly Ser Gly Gly Gly  Ser Gly Gly 
    1010                 1015                 1020             


Ser Ala  Trp Ser His Pro Gln  Phe Glu Lys Gly Arg  Gly Ser Gly 
    1025                 1030                 1035             


Cys 
    


<210>  3499
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 119

<400>  3499

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Gln Glu Ile Lys Arg Ile 
1               5                   10                  15      


Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys Ala 
            20                  25                  30          


Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr Pro 
        35                  40                  45              


Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn Ile 
    50                  55                  60                  


Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu 
65                  70                  75                  80  


Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu 
                85                  90                  95      


Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro 
            100                 105                 110         


Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly 
        115                 120                 125             


Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln 
    130                 135                 140                 


Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro 
145                 150                 155                 160 


His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu 
                165                 170                 175     


Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr 
            180                 185                 190         


Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile 
        195                 200                 205             


His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile 
    210                 215                 220                 


Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp 
225                 230                 235                 240 


Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile 
                245                 250                 255     


Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala 
            260                 265                 270         


Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile 
        275                 280                 285             


Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn 
    290                 295                 300                 


Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln 
305                 310                 315                 320 


Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys 
                325                 330                 335     


Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp 
            340                 345                 350         


Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys 
        355                 360                 365             


Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln 
    370                 375                 380                 


Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly 
385                 390                 395                 400 


Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu Glu 
                405                 410                 415     


Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu 
        435                 440                 445             


Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala 
465                 470                 475                 480 


Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val Pro Pro Ala Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Ser Glu Asn Leu  Tyr Phe Gln Gly Ser  Ala Trp Ser 
        995                 1000                 1005             


His Pro  Gln Phe Glu Lys Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1010                 1015                 1020             


Gly Ser  Ala Trp Ser His Pro  Gln Phe Glu Lys Gly  Arg Gly Ser 
    1025                 1030                 1035             


Gly Cys  
    1040 


<210>  3500
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 438

<400>  3500

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Gln Glu Ile Lys Arg Ile 
1               5                   10                  15      


Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys Ala 
            20                  25                  30          


Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr Pro 
        35                  40                  45              


Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn Ile 
    50                  55                  60                  


Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu 
65                  70                  75                  80  


Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu 
                85                  90                  95      


Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro 
            100                 105                 110         


Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly 
        115                 120                 125             


Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln 
    130                 135                 140                 


Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro 
145                 150                 155                 160 


His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu 
                165                 170                 175     


Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr 
            180                 185                 190         


Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile 
        195                 200                 205             


His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile 
    210                 215                 220                 


Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp 
225                 230                 235                 240 


Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile 
                245                 250                 255     


Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala 
            260                 265                 270         


Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile 
        275                 280                 285             


Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn 
    290                 295                 300                 


Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln 
305                 310                 315                 320 


Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys 
                325                 330                 335     


Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp 
            340                 345                 350         


Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys 
        355                 360                 365             


Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln 
    370                 375                 380                 


Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys Gly 
385                 390                 395                 400 


Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu Glu 
                405                 410                 415     


Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu 
        435                 440                 445             


Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala 
465                 470                 475                 480 


Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val Pro Pro Ala Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Ser Glu Asn Leu  Tyr Phe Gln Gly Ser  Ala Trp Ser 
        995                 1000                 1005             


His Pro  Gln Phe Glu Lys Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1010                 1015                 1020             


Gly Ser  Ala Trp Ser His Pro  Gln Phe Glu Lys Gly  Arg Gly Ser 
    1025                 1030                 1035             


Gly Cys  
    1040 


<210>  3501
<211>  1040
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 457

<400>  3501

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Gln Glu Ile Lys Arg Ile 
1               5                   10                  15      


Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys Ala 
            20                  25                  30          


Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr Pro 
        35                  40                  45              


Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn Ile 
    50                  55                  60                  


Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu Leu 
65                  70                  75                  80  


Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp Glu 
                85                  90                  95      


Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln Pro 
            100                 105                 110         


Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp Gly 
        115                 120                 125             


Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys Gln 
    130                 135                 140                 


Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys Pro 
145                 150                 155                 160 


His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg Leu 
                165                 170                 175     


Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val Thr 
            180                 185                 190         


Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser Ile 
        195                 200                 205             


His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln Ile 
    210                 215                 220                 


Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser Asp 
225                 230                 235                 240 


Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp Ile 
                245                 250                 255     


Ile Leu Glu His Lys Lys Val Ile Lys Lys Asn Glu Lys Arg Leu Ala 
            260                 265                 270         


Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys Ile 
        275                 280                 285             


Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr Asn 
    290                 295                 300                 


Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp Gln 
305                 310                 315                 320 


Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu Lys 
                325                 330                 335     


Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val Asp 
            340                 345                 350         


Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys Lys 
        355                 360                 365             


Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg Gln 
    370                 375                 380                 


Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro Glu Asp Arg Lys Lys Gly 
385                 390                 395                 400 


Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu Glu 
                405                 410                 415     


Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu Glu 
        435                 440                 445             


Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu Ala 
465                 470                 475                 480 


Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val Pro Pro Ala Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Ser Glu Asn Leu  Tyr Phe Gln Gly Ser  Ala Trp Ser 
        995                 1000                 1005             


His Pro  Gln Phe Glu Lys Gly  Gly Gly Ser Gly Gly  Gly Ser Gly 
    1010                 1015                 1020             


Gly Ser  Ala Trp Ser His Pro  Gln Phe Glu Lys Gly  Arg Gly Ser 
    1025                 1030                 1035             


Gly Cys  
    1040 


<210>  3502
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 119

<400>  3502
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gttcggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcat cgaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggtacaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  3503
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 457

<400>  3503
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac aagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcc ccgaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgctgc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaacccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  3504
<211>  2928
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 438

<400>  3504
caagagatca agagaatcaa caagatcaga aggagactgg tcaaggacag caacacaaag       60

aaggccggca agacaggccc catgaaaacc ctgctcgtca gagtgatgac ccctgacctg      120

agagagcggc tggaaaacct gagaaagaag cccgagaaca tccctcagcc tatcagcaac      180

accagcaggg ccaacctgaa caagctgctg accgactaca ccgagatgaa gaaagccatc      240

ctgcacgtgt actgggaaga gttccagaaa gaccccgtgg gcctgatgag cagagttgct      300

cagcccgctc ctaagaacat cgaccagaga aagctgatcc ccgtgaagga cggcaacgag      360

agactgacct ctagcggctt tgcctgcagc cagtgttgcc agcctctgta cgtgtacaag      420

ctggaacaag tgaacgacaa gggcaagccc cacaccaact acttcggcag atgcaacgtg      480

tccgagcacg agaggctgat cctgctgtct cctcacaagc ccgaggccaa cgatgagctg      540

gtcacataca gcctgggcaa gttcggacag agagccctgg acttctacag catccacgtg      600

accagggaga gcaatcaccc tgtgaagccc ctggaacaga tcggcggcaa tagctgtgcc      660

tctggacctg tgggaaaagc cctgagcgac gcctgtatgg gagccgtggc atccttcctg      720

accaagtacc aggacatcat cctggaacac cagaaagtga tcaagaagaa cgagaaaaga      780

ctggccaacc tcaaggatat cgccagcgct aacggcctgg cctttcctaa gatcaccctg      840

cctccacagc ctcacaccaa agagggcatc gaggcctaca acaacgtggt ggcccagatc      900

gtgatttggg tcaacctgaa tctgtggcag aagctgaaga tcggcaggga cgaagccaag      960

ccactgcaga gactgaaggg cttccctagc ttccctctgg tggaaagaca ggccaatgaa     1020

gtggattggt gggacatggt ctgcaacgtg aagaagctga tcaacgagaa gaaagaggat     1080

ggcaaggttt tctggcagaa cctggccggc tacaagagac aagaagccct gaggccttac     1140

ctgagcagcg aagaggaccg gaagaagggc aagaagttcg ccagatacca gctgggcgac     1200

ctgctgaagc acctggaaaa gaagcacggc gaggactggg gcaaagtgta cgatgaggcc     1260

tgggagagaa tcgacaagaa ggtggaaggc ctgagcaagc acattaagct ggaagaggaa     1320

agaaggagcg aggacgccca atctaaagcc gctctgaccg attggctgag agccaaggcc     1380

agctttgtga tcgagggcct gaaagaggcc gacaaggacg agttctgcag atgcgagctg     1440

aagctgcaga agtggtacgg cgatctgaga ggcaagccct tcgccattga ggccgagaac     1500

agcatcctgg acatcagcgg cttcagcaag cagtacaact gcgccttcat ttggcagaaa     1560

gacggcgtca agaaactgaa cctgtacctg atcatcaatt acttcaaagg cggcaagctg     1620

cggttcaaga agatcaaacc cgaggccttc gaggctaaca gattctacac cgtgatcaac     1680

aaaaagtccg gcgagatcgt gcccatggaa gtgaacttca acttcgacga ccccaacctg     1740

attatcctgc ctctggcctt cggcaagaga cagggcagag agttcatctg gaacgatctg     1800

ctgagcctgg aaaccggctc tctgaagctg gccaatggca gagtgatcga gaaaaccctg     1860

tacaacagga gaaccagaca ggacgagcct gctctgtttg tggccctgac cttcgagaga     1920

agagaggtgc tggacagcag caacatcaag cccatgaacc tgatcggcgt ggaccggggc     1980

gagaatatcc ctgctgtgat cgccctgaca gaccctgaag gatgcccact gagcagattc     2040

aaggactccc tgggcaaccc tacacacatc ctgagaatcg gcgagagcta caaagagaag     2100

cagaggacaa tccaggccaa gaaagaggtg gaacagagaa gagccggcgg atactctagg     2160

aagtacgcca gcaaggccaa gaatctggcc gacgacatgg tccgaaacac cgccagagat     2220

ctgctgtact acgccgtgac acaggacgcc atgctgatct tcgagaatct gagcagaggc     2280

ttcggccggc agggcaagag aacctttatg gccgagaggc agtacaccag aatggaagat     2340

tggctcacag ctaaactggc ctacgaggga ctgagcaaga cctacctgtc caaaacactg     2400

gcccagtata cctccaagac ctgcagcaat tgcggcttca ccatcaccag cgccgactac     2460

gacagagtgc tggaaaagct caagaaaacc gccaccggct ggatgaccac catcaacggc     2520

aaagagctga aggttgaggg ccagatcacc tactacaaca ggaggaagag gcagaacgtc     2580

gtgaaggatc tgagcgtgga actggacaga ctgagcgaag agagcgtgaa caacgacatc     2640

agcagctgga caaagggcag atcaggcgag gctctgagcc tgctgaagaa gaggtttagc     2700

cacagacctg tgcaagagaa gttcgtgtgc ctgaactgcg gcttcgagac acacgccgat     2760

gaacaggctg ccctgaacat tgccagaagc tggctgttcc tgagaagcca agagtacaag     2820

aagtaccaga ccaacaagac caccggcaac accgacaaga gggcctttgt ggaaacctgg     2880

cagagcttct acagaaaaaa gctgaaagaa gtctggaagc ccgccgtg                  2928


<210>  3505
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 119

<400>  3505

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  3506
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 457

<400>  3506

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Lys Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Pro 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Pro Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  3507
<211>  976
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 438

<400>  3507

Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp 
385                 390                 395                 400 


Leu Leu Lys His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu 
785                 790                 795                 800 


Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr 
                805                 810                 815     


Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr 
            820                 825                 830         


Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln 
        835                 840                 845             


Ile Thr Tyr Tyr Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu 
    850                 855                 860                 


Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile 
865                 870                 875                 880 


Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys 
                885                 890                 895     


Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn 
            900                 905                 910         


Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala 
        915                 920                 925             


Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr 
    930                 935                 940                 


Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp 
945                 950                 955                 960 


Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
                965                 970                 975     


<210>  3508
<211>  987
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 278

<400>  3508

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu Gln 
    210                 215                 220                 


Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg Leu 
            260                 265                 270         


Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro Lys 
        275                 280                 285             


Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala Tyr 
    290                 295                 300                 


Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985         


<210>  3509
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 279

<400>  3509

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val 
            980                 985     


<210>  3510
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 280

<400>  3510

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  3511
<211>  1006
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 285

<400>  3511

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro His Lys Lys 
            980                 985                 990         


Lys His Pro Asp Ala Ser Val Asn  Phe Ser Glu Phe Ser  Lys 
        995                 1000                 1005     


<210>  3512
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 286

<400>  3512

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Gln Arg Pro 
            980                 985                 990         


Gly Pro Tyr Asp Arg Pro Gln Arg  Pro Gly Pro Tyr Asp  Arg Pro 
        995                 1000                 1005         


<210>  3513
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 287

<400>  3513

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Leu Ser Pro 
            980                 985                 990         


Ser Leu Ser Pro Leu Leu Ser Pro  Ser Leu Ser Pro Leu  
        995                 1000                 1005 


<210>  3514
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 288

<400>  3514

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Met Ser Ser Gly 
        115                 120                 125             


Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu 
    130                 135                 140                 


Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys 
145                 150                 155                 160 


Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro 
                165                 170                 175     


Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
            180                 185                 190         


Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His 
        195                 200                 205             


Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly 
    210                 215                 220                 


Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser 
225                 230                 235                 240 


Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile 
                245                 250                 255     


Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala 
            260                 265                 270         


Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr 
        275                 280                 285             


Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile 
    290                 295                 300                 


Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu 
305                 310                 315                 320 


Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val 
                325                 330                 335     


Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val 
            340                 345                 350         


Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln 
        355                 360                 365             


Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser 
    370                 375                 380                 


Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe 
385                 390                 395                 400 


Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly 
                405                 410                 415     


Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly 
            420                 425                 430         


Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala 
        435                 440                 445             


Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe 
    450                 455                 460                 


Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys 
465                 470                 475                 480 


Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe 
                485                 490                 495     


Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys 
            500                 505                 510         


Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu 
        515                 520                 525             


Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe 
    530                 535                 540                 


Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val 
545                 550                 555                 560 


Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn 
                565                 570                 575     


Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg 
            580                 585                 590         


Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly 
        595                 600                 605             


Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn 
    610                 615                 620                 


Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe 
625                 630                 635                 640 


Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu 
                645                 650                 655     


Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr 
            660                 665                 670         


Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn 
        675                 680                 685             


Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg 
    690                 695                 700                 


Thr Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr 
705                 710                 715                 720 


Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val 
                725                 730                 735     


Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala 
            740                 745                 750         


Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys 
        755                 760                 765             


Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu 
    770                 775                 780                 


Thr Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Arg Gly 
            980                 985                 990         


Lys Gly Gly Lys Gly Leu Gly Lys  Gly Gly Ala Lys Arg  His Arg Lys 
        995                 1000                 1005             


<210>  3515
<211>  1013
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 290

<400>  3515

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Ser Arg Arg 
            980                 985                 990         


Arg Lys Ala Asn Pro Thr Lys Leu  Ser Glu Asn Ala Lys  Lys Leu Ala 
        995                 1000                 1005             


Lys Glu  Val Glu Asn 
    1010             


<210>  3516
<211>  998
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 291

<400>  3516

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Pro Ala Ala 
            980                 985                 990         


Lys Arg Val Lys Leu Asp 
        995             


<210>  3517
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 293

<400>  3517

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Ser 
            980                 985                 990         


Phe Ser Lys Ala Phe 
        995         


<210>  3518
<211>  1008
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 300

<400>  3518

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val Thr Ser Pro Lys Lys Lys Arg Lys Val Pro Pro Pro Lys Arg Gly 
            980                 985                 990         


Ile Asn Asp Arg Asn Phe Trp Arg  Gly Glu Asn Glu Arg  Lys Thr Arg 
        995                 1000                 1005             


<210>  3519
<211>  1007
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 492

<400>  3519

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Lys Lys Lys Arg  Lys Val 
        995                 1000                 1005         


<210>  3520
<211>  1009
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX construct CasX 493

<400>  3520

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Met Gln Glu Ile Lys 
1               5                   10                  15      


Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys 
            20                  25                  30          


Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met 
        35                  40                  45              


Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu 
    50                  55                  60                  


Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys 
65                  70                  75                  80  


Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr 
                85                  90                  95      


Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala 
            100                 105                 110         


Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys 
        115                 120                 125             


Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys 
    130                 135                 140                 


Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly 
145                 150                 155                 160 


Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu 
                165                 170                 175     


Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val Pro Pro Pro  Pro Ala Ala Lys Arg  Val Lys Leu 
        995                 1000                 1005             


Asp 
    


<210>  3521
<211>  21
<212>  DNA
<213>  Betapolyomavirus macaca mulatta polyomavirus 1Nuclear localization sequence

<400>  3521
ccaaagaaga agcggaaggt c                                                 21


<210>  3522
<211>  51
<212>  DNA
<213>  Unknown

<220>
<223>  Nuclear localization sequence

<400>  3522
cacaagaaga aacatccaga cgcatcagtc aactttagcg agttcagtaa a                51


<210>  3523
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Nuclear localization sequence

<400>  3523
cagcgccctg ggccttacga taggccgcaa agacccggac cgtatgatcg ccct             54


<210>  3524
<211>  48
<212>  DNA
<213>  Unknown

<220>
<223>  Nuclear localization sequence

<400>  3524
ctcagcccga gtcttagtcc actgctttcc ccgtccctgt ctccactg                    48


<210>  3525
<211>  54
<212>  DNA
<213>  Unknown

<220>
<223>  Nuclear localization sequence

<400>  3525
cggggcaagg gtggcaaggg gcttggcaag gggggggcaa agaggcacag gaag             54


<210>  3526
<211>  72
<212>  DNA
<213>  Caenorhabditis elegansNuclear localization sequence

<400>  3526
agccgccgca gaaaagccaa tcctacaaaa ctgtcagaaa atgcgaaaaa acttgctaag       60

gaggtggaaa ac                                                           72


<210>  3527
<211>  27
<212>  DNA
<213>  Homo sapiensNuclear localization sequence

<400>  3527
cctgccgcaa agcgagtgaa attggac                                           27


<210>  3528
<211>  24
<212>  DNA
<213>  Unknown

<220>
<223>  Nuclear localization sequence

<400>  3528
aagcggtcct tcagtaaggc cttt                                              24


<210>  3529
<211>  57
<212>  DNA
<213>  Alphainfluenzavirus influenza A virusNuclear localization sequence

<400>  3529
aaacggggaa taaacgaccg gaacttctgg cgcggggaaa acgagcgcaa aacccga          57


<210>  3530
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 387 construct

<400>  3530
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3531
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 395 construct

<400>  3531
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagttcggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg catcgaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  3532
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 485 construct

<400>  3532
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  3533
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 486 construct

<400>  3533
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctga agcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggaggaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  3534
<211>  2988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 487 construct

<400>  3534
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcccg ctcctaagaa catcgaccag      360

agaaagctga tccccgtgaa ggacggcaac gagagactga cctctagcgg ctttgcctgc      420

agccagtgtt gccagcctct gtacgtgtac aagctggaac aagtgaacga caagggcaag      480

ccccacacca actacttcgg cagatgcaac gtgtccgagc acgagaggct gatcctgctg      540

tctcctcaca agcccgaggc caacgatgag ctggtcacat acagcctggg caagttcgga      600

cagagagccc tggacttcta cagcatccac gtgaccaaag aaagcacaca ccccgtgaag      660

cccctggctc agatcgccgg caatagatac gcctctggac ctgtgggcaa agccctgtcc      720

gatgcctgca tgggaacaat cgccagcttc ctgagcaagt accaggacat catcatcgag      780

caccagaagg tggtcaaggg caaccagaag agactggaaa gcctgaggga gctggccggc      840

aaagagaacc tggaataccc cagcgtgacc ctgcctcctc agcctcacac aaaagaaggc      900

gtggacgcct acaacgaagt gatcgccaga gtgagaatgt gggtcaacct gaacctgtgg      960

cagaagctga aactgtccag ggacgacgcc aagcctctgc tgagactgaa gggcttccct     1020

agcttccctc tggtggaaag acaggccaat gaagtggatt ggtgggacat ggtctgcaac     1080

gtgaagaagc tgatcaacga gaagaaagag gatggcaagg ttttctggca gaacctggcc     1140

ggctacaaga gacaagaagc cctgaggcct tacctgagca gcgaagagga ccggaagaag     1200

ggcaagaagt tcgccagata ccagctgggc gacctgctgc tgcacctgga aaagaagcac     1260

ggcgaggact ggggcaaagt gtacgatgag gcctgggaga gaatcgacaa gaaggtggaa     1320

ggcctgagca agcacattaa gctggaagag gaaagaagga gcgaggacgc ccaatctaaa     1380

gccgctctga ccgattggct gagagccaag gccagctttg tgatcgaggg cctgaaagag     1440

gccgacaagg acgagttctg cagatgcgag ctgaagctgc agaagtggta cggcgatctg     1500

agaggcaagc ccttcgccat tgaggccgag aacagcatcc tggacatcag cggcttcagc     1560

aagcagtaca actgcgcctt catttggcag aaagacggcg tcaagaaact gaacctgtac     1620

ctgatcatca attacttcaa aggcggcaag ctgcggttca agaagatcaa acccgaggcc     1680

ttcgaggcta acagattcta caccgtgatc aacaaaaagt ccggcgagat cgtgcccatg     1740

gaagtgaact tcaacttcga cgaccccaac ctgattatcc tgcctctggc cttcggcaag     1800

agacagggca gagagttcat ctggaacgat ctgctgagcc tggaaaccgg ctctctgaag     1860

ctggccaatg gcagagtgat cgagaaaacc ctgtacaaca ggagaaccag acaggacgag     1920

cctgctctgt ttgtggccct gaccttcgag agaagagagg tgctggacag cagcaacatc     1980

aagcccatga acctgatcgg cgtggaccgg ggcgagaata tccctgctgt gatcgccctg     2040

acagaccctg aaggatgccc actgagcaga ttcaaggact ccctgggcaa ccctacacac     2100

atcctgagaa tcggcgagag ctacaaagag aagcagagga caatccaggc caagaaagag     2160

gtggaacaga gaagagccgg cggatactct aggaagtacg ccagcaaggc caagaatctg     2220

gccgacgaca tggtccgaaa caccgccaga gatctgctgt actacgccgt gacacaggac     2280

gccatgctga tcttcgagaa tctgagcaga ggcttcggcc ggcagggcaa gagaaccttt     2340

atggccgaga ggcagtacac cagaatggaa gattggctca cagctaaact ggcctacgag     2400

ggactgagca agacctacct gtccaaaaca ctggcccagt atacctccaa gacctgcagc     2460

aattgcggct tcaccatcac cagcgccgac tacgacagag tgctggaaaa gctcaagaaa     2520

accgccaccg gctggatgac caccatcaac ggcaaagagc tgaaggttga gggccagatc     2580

acctactaca acaggtacaa gaggcagaac gtcgtgaagg atctgagcgt ggaactggac     2640

agactgagcg aagagagcgt gaacaacgac atcagcagct ggacaaaggg cagatcaggc     2700

gaggctctga gcctgctgaa gaagaggttt agccacagac ctgtgcaaga gaagttcgtg     2760

tgcctgaact gcggcttcga gacacacgcc gatgaacagg ctgccctgaa cattgccaga     2820

agctggctgt tcctgagaag ccaagagtac aagaagtacc agaccaacaa gaccaccggc     2880

aacaccgaca agagggcctt tgtggaaacc tggcagagct tctacagaaa aaagctgaaa     2940

gaagtctgga agcccgccgt gactagtcca aaaaagaaga gaaaggta                  2988


<210>  3535
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 488 construct

<400>  3535
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagttc ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcatcgac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3536
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 489 construct

<400>  3536
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3537
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 490 construct

<400>  3537
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgaagcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggag gaagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3538
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 491 construct

<400>  3538
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca aagaaagcac acaccccgtg      660

aagcccctgg ctcagatcgc cggcaataga tacgcctctg gacctgtggg caaagccctg      720

tccgatgcct gcatgggaac aatcgccagc ttcctgagca agtaccagga catcatcatc      780

gagcaccaga aggtggtcaa gggcaaccag aagagactgg aaagcctgag ggagctggcc      840

ggcaaagaga acctggaata ccccagcgtg accctgcctc ctcagcctca cacaaaagaa      900

ggcgtggacg cctacaacga agtgatcgcc agagtgagaa tgtgggtcaa cctgaacctg      960

tggcagaagc tgaaactgtc cagggacgac gccaagcctc tgctgagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3539
<211>  2991
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CasX 494 construct

<400>  3539
atggccccaa agaagaagcg gaaggtctct agacaagaga tcaagagaat caacaagatc       60

agaaggagac tggtcaagga cagcaacaca aagaaggccg gcaagacagg ccccatgaaa      120

accctgctcg tcagagtgat gacccctgac ctgagagagc ggctggaaaa cctgagaaag      180

aagcccgaga acatccctca gcctatcagc aacaccagca gggccaacct gaacaagctg      240

ctgaccgact acaccgagat gaagaaagcc atcctgcacg tgtactggga agagttccag      300

aaagaccccg tgggcctgat gagcagagtt gctcagcctg ccagcaagaa gatcgaccag      360

aacaagctga agcccgagat ggacgagaag ggcaatctga ccacagccgg ctttgcctgc      420

tctcagtgtg gccagcctct gttcgtgtac aagctggaac aggtgtccga gaaaggcaag      480

gcctacacca actacttcgg cagatgtaac gtggccgagc acgagaagct gattctgctg      540

gcccagctga aacctgagaa ggactctgat gaggccgtga cctacagcct gggcaagttt      600

ggacagagag ccctggactt ctacagcatc cacgtgacca gggagagcaa tcaccctgtg      660

aagcccctgg aacagatcgg cggcaatagc tgtgcctctg gacctgtggg aaaagccctg      720

agcgacgcct gtatgggagc cgtggcatcc ttcctgacca agtaccagga catcatcctg      780

gaacaccaga aagtgatcaa gaagaacgag aaaagactgg ccaacctcaa ggatatcgcc      840

agcgctaacg gcctggcctt tcctaagatc accctgcctc cacagcctca caccaaagag      900

ggcatcgagg cctacaacaa cgtggtggcc cagatcgtga tttgggtcaa cctgaatctg      960

tggcagaagc tgaagatcgg cagggacgaa gccaagccac tgcagagact gaagggcttc     1020

cctagcttcc ctctggtgga aagacaggcc aatgaagtgg attggtggga catggtctgc     1080

aacgtgaaga agctgatcaa cgagaagaaa gaggatggca aggttttctg gcagaacctg     1140

gccggctaca agagacaaga agccctgagg ccttacctga gcagcgaaga ggaccggaag     1200

aagggcaaga agttcgccag ataccagctg ggcgacctgc tgctgcacct ggaaaagaag     1260

cacggcgagg actggggcaa agtgtacgat gaggcctggg agagaatcga caagaaggtg     1320

gaaggcctga gcaagcacat taagctggaa gaggaaagaa ggagcgagga cgcccaatct     1380

aaagccgctc tgaccgattg gctgagagcc aaggccagct ttgtgatcga gggcctgaaa     1440

gaggccgaca aggacgagtt ctgcagatgc gagctgaagc tgcagaagtg gtacggcgat     1500

ctgagaggca agcccttcgc cattgaggcc gagaacagca tcctggacat cagcggcttc     1560

agcaagcagt acaactgcgc cttcatttgg cagaaagacg gcgtcaagaa actgaacctg     1620

tacctgatca tcaattactt caaaggcggc aagctgcggt tcaagaagat caaacccgag     1680

gccttcgagg ctaacagatt ctacaccgtg atcaacaaaa agtccggcga gatcgtgccc     1740

atggaagtga acttcaactt cgacgacccc aacctgatta tcctgcctct ggccttcggc     1800

aagagacagg gcagagagtt catctggaac gatctgctga gcctggaaac cggctctctg     1860

aagctggcca atggcagagt gatcgagaaa accctgtaca acaggagaac cagacaggac     1920

gagcctgctc tgtttgtggc cctgaccttc gagagaagag aggtgctgga cagcagcaac     1980

atcaagccca tgaacctgat cggcgtggac cggggcgaga atatccctgc tgtgatcgcc     2040

ctgacagacc ctgaaggatg cccactgagc agattcaagg actccctggg caaccctaca     2100

cacatcctga gaatcggcga gagctacaaa gagaagcaga ggacaatcca ggccaagaaa     2160

gaggtggaac agagaagagc cggcggatac tctaggaagt acgccagcaa ggccaagaat     2220

ctggccgacg acatggtccg aaacaccgcc agagatctgc tgtactacgc cgtgacacag     2280

gacgccatgc tgatcttcga gaatctgagc agaggcttcg gccggcaggg caagagaacc     2340

tttatggccg agaggcagta caccagaatg gaagattggc tcacagctaa actggcctac     2400

gagggactga gcaagaccta cctgtccaaa acactggccc agtatacctc caagacctgc     2460

agcaattgcg gcttcaccat caccagcgcc gactacgaca gagtgctgga aaagctcaag     2520

aaaaccgcca ccggctggat gaccaccatc aacggcaaag agctgaaggt tgagggccag     2580

atcacctact acaacaggta caagaggcag aacgtcgtga aggatctgag cgtggaactg     2640

gacagactga gcgaagagag cgtgaacaac gacatcagca gctggacaaa gggcagatca     2700

ggcgaggctc tgagcctgct gaagaagagg tttagccaca gacctgtgca agagaagttc     2760

gtgtgcctga actgcggctt cgagacacac gccgatgaac aggctgccct gaacattgcc     2820

agaagctggc tgttcctgag aagccaagag tacaagaagt accagaccaa caagaccacc     2880

ggcaacaccg acaagagggc ctttgtggaa acctggcaga gcttctacag aaaaaagctg     2940

aaagaagtct ggaagcccgc cgtgactagt ccaaaaaaga agagaaaggt a              2991


<210>  3540
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 387 construct

<400>  3540

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3541
<211>  1005
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 395 construct

<400>  3541

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val Thr Ser Pro Lys  Lys Lys Arg Lys Val  
        995                 1000                 1005 


<210>  3542
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 485 construct

<400>  3542

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  3543
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 486 construct

<400>  3543

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  3544
<211>  996
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 487 construct

<400>  3544

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu Ile Pro Val Lys Asp 
        115                 120                 125             


Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala Cys Ser Gln Cys Cys 
    130                 135                 140                 


Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val Asn Asp Lys Gly Lys 
145                 150                 155                 160 


Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val Ser Glu His Glu Arg 
                165                 170                 175     


Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala Asn Asp Glu Leu Val 
            180                 185                 190         


Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr Ser 
        195                 200                 205             


Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala Gln 
    210                 215                 220                 


Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu Ser 
225                 230                 235                 240 


Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln Asp 
                245                 250                 255     


Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg Leu 
            260                 265                 270         


Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro Ser 
        275                 280                 285             


Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala Tyr 
    290                 295                 300                 


Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu Trp 
305                 310                 315                 320 


Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg Leu 
                325                 330                 335     


Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu Val 
            340                 345                 350         


Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu Lys 
        355                 360                 365             


Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys Arg 
    370                 375                 380                 


Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys Lys 
385                 390                 395                 400 


Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His Leu 
                405                 410                 415     


Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala Trp 
            420                 425                 430         


Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys Leu 
        435                 440                 445             


Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu Thr 
    450                 455                 460                 


Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys Glu 
465                 470                 475                 480 


Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys Trp 
                485                 490                 495     


Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn Ser 
            500                 505                 510         


Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile 
        515                 520                 525             


Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn 
    530                 535                 540                 


Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala 
545                 550                 555                 560 


Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu 
                565                 570                 575     


Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile 
            580                 585                 590         


Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp 
        595                 600                 605             


Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly 
    610                 615                 620                 


Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu 
625                 630                 635                 640 


Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp 
                645                 650                 655     


Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly Glu 
            660                 665                 670         


Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu 
        675                 680                 685             


Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile 
    690                 695                 700                 


Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu 
705                 710                 715                 720 


Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys 
                725                 730                 735     


Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu 
            740                 745                 750         


Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu 
        755                 760                 765             


Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg 
    770                 775                 780                 


Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu 
785                 790                 795                 800 


Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser 
                805                 810                 815     


Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp 
            820                 825                 830         


Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr 
        835                 840                 845             


Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn 
    850                 855                 860                 


Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp 
865                 870                 875                 880 


Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys 
                885                 890                 895     


Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His 
            900                 905                 910         


Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr 
        915                 920                 925             


His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe 
    930                 935                 940                 


Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly 
945                 950                 955                 960 


Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg 
                965                 970                 975     


Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys Lys 
            980                 985                 990         


Lys Arg Lys Val 
        995     


<210>  3545
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 488 construct

<400>  3545

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3546
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 489 construct

<400>  3546

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3547
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 490 construct

<400>  3547

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Lys His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Arg Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3548
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 491 construct

<400>  3548

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Lys Glu Ser Thr His Pro Val Lys Pro Leu Ala 
    210                 215                 220                 


Gln Ile Ala Gly Asn Arg Tyr Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Thr Ile Ala Ser Phe Leu Ser Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Ile Glu His Gln Lys Val Val Lys Gly Asn Gln Lys Arg 
            260                 265                 270         


Leu Glu Ser Leu Arg Glu Leu Ala Gly Lys Glu Asn Leu Glu Tyr Pro 
        275                 280                 285             


Ser Val Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Val Asp Ala 
    290                 295                 300                 


Tyr Asn Glu Val Ile Ala Arg Val Arg Met Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Leu Ser Arg Asp Asp Ala Lys Pro Leu Leu Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3549
<211>  997
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX 494 construct

<400>  3549

Met Ala Pro Lys Lys Lys Arg Lys Val Ser Arg Gln Glu Ile Lys Arg 
1               5                   10                  15      


Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp Ser Asn Thr Lys Lys 
            20                  25                  30          


Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu Val Arg Val Met Thr 
        35                  40                  45              


Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg Lys Lys Pro Glu Asn 
    50                  55                  60                  


Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala Asn Leu Asn Lys Leu 
65                  70                  75                  80  


Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile Leu His Val Tyr Trp 
                85                  90                  95      


Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met Ser Arg Val Ala Gln 
            100                 105                 110         


Pro Ala Ser Lys Lys Ile Asp Gln Asn Lys Leu Lys Pro Glu Met Asp 
        115                 120                 125             


Glu Lys Gly Asn Leu Thr Thr Ala Gly Phe Ala Cys Ser Gln Cys Gly 
    130                 135                 140                 


Gln Pro Leu Phe Val Tyr Lys Leu Glu Gln Val Ser Glu Lys Gly Lys 
145                 150                 155                 160 


Ala Tyr Thr Asn Tyr Phe Gly Arg Cys Asn Val Ala Glu His Glu Lys 
                165                 170                 175     


Leu Ile Leu Leu Ala Gln Leu Lys Pro Glu Lys Asp Ser Asp Glu Ala 
            180                 185                 190         


Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
        195                 200                 205             


Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val Lys Pro Leu Glu 
    210                 215                 220                 


Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val Gly Lys Ala Leu 
225                 230                 235                 240 


Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu Thr Lys Tyr Gln 
                245                 250                 255     


Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys Asn Glu Lys Arg 
            260                 265                 270         


Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly Leu Ala Phe Pro 
        275                 280                 285             


Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu Gly Ile Glu Ala 
    290                 295                 300                 


Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val Asn Leu Asn Leu 
305                 310                 315                 320 


Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys Pro Leu Gln Arg 
                325                 330                 335     


Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg Gln Ala Asn Glu 
            340                 345                 350         


Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys Leu Ile Asn Glu 
        355                 360                 365             


Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu Ala Gly Tyr Lys 
    370                 375                 380                 


Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser Glu Glu Asp Arg Lys 
385                 390                 395                 400 


Lys Gly Lys Lys Phe Ala Arg Tyr Gln Leu Gly Asp Leu Leu Leu His 
                405                 410                 415     


Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val Tyr Asp Glu Ala 
            420                 425                 430         


Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser Lys His Ile Lys 
        435                 440                 445             


Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser Lys Ala Ala Leu 
    450                 455                 460                 


Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile Glu Gly Leu Lys 
465                 470                 475                 480 


Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu Lys Leu Gln Lys 
                485                 490                 495     


Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile Glu Ala Glu Asn 
            500                 505                 510         


Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe 
        515                 520                 525             


Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile 
    530                 535                 540                 


Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu 
545                 550                 555                 560 


Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly 
                565                 570                 575     


Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu 
            580                 585                 590         


Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile 
        595                 600                 605             


Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn 
    610                 615                 620                 


Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp 
625                 630                 635                 640 


Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu 
                645                 650                 655     


Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Val Asp Arg Gly 
            660                 665                 670         


Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro 
        675                 680                 685             


Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg 
    690                 695                 700                 


Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys 
705                 710                 715                 720 


Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser 
                725                 730                 735     


Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp 
            740                 745                 750         


Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn 
        755                 760                 765             


Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu 
    770                 775                 780                 


Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr 
785                 790                 795                 800 


Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
                805                 810                 815     


Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr 
            820                 825                 830         


Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr 
        835                 840                 845             


Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr 
    850                 855                 860                 


Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu 
865                 870                 875                 880 


Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr 
                885                 890                 895     


Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser 
            900                 905                 910         


His Arg Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu 
        915                 920                 925             


Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu 
    930                 935                 940                 


Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr 
945                 950                 955                 960 


Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr 
                965                 970                 975     


Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala Val Thr Ser Pro Lys 
            980                 985                 990         


Lys Lys Arg Lys Val 
        995         


<210>  3550
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 promoter primer

<400>  3550
gaaattaata cgactcacta ta                                                22


<210>  3551
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone fwd

<400>  3551
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaag                                           87


<210>  3552
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2 backbone rev

<400>  3552
ctttgatgct tcttatttat cggatttctc tccgataaat aagcgcttta cccatacgac       60

atagtcgctg gtgatggc                                                     78


<210>  3553
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg2.7.37 spacer primer

<400>  3553
cggagcgaga catctcggcc ctttgatgct tcttatttat cggatttctc tccg             54


<210>  3554
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone fwd

<400>  3554
gaaattaata cgactcacta taggtactgg cgcttttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  3555
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32 backbone rev

<400>  3555
ctttgatgct tccctccgaa gagggcgctt tacccatacg acatag                      46


<210>  3556
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg32.7.37 spacer primer

<400>  3556
cggagcgaga catctcggcc ctttgatgct tccctccgaa gag                         43


<210>  3557
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone fwd

<400>  3557
gaaattaata cgactcacta taggtactgg cgcctttatc tcattacttt gagagccatc       60

accagcgact atgtcgtatg ggtaaagcgc                                        90


<210>  3558
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64 backbone rev

<400>  3558
ctttgatgct tcttacggac cgaagtccgt aagcgcttta cccatacgac atag             54


<210>  3559
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg64.7.37 spacer primer

<400>  3559
cggagcgaga catctcggcc ctttgatgct tcttacggac cgaag                       45


<210>  3560
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone fwd

<400>  3560
gaaattaata cgactcacta taactggcgc ttttatctga ttactttgag agccatcacc       60

agcgactatg tcgtagtggg taaagct                                           87


<210>  3561
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174 backbone rev

<400>  3561
ctttgatgct ccctccgaag agggagcttt acccactacg acatagtcgc                  50


<210>  3562
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sg174.7.37 spacer primer

<400>  3562
cggagcgaga catctcggcc ctttgatgct ccctcc                                 36


<210>  3563
<211>  130
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sg2 RNA product

<400>  3563
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu auuuaucgga gagaaauccg auaaauaaga agcaucaaag ggccgagaug      120

ucucgcuccg                                                             130


<210>  3564
<211>  107
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sg32 RNA product

<400>  3564
gguacuggcg cuuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgccc ucuucggagg gaagcaucaa agggccgaga ugucucg                    107


<210>  3565
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sg64 RNA product

<400>  3565
gguacuggcg ccuuuaucuc auuacuuuga gagccaucac cagcgacuau gucguauggg       60

uaaagcgcuu acggacuucg guccguaaga agcaucaaag ggccgagaug ucucgcuccg      120


<210>  3566
<211>  109
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sg174 RNA product

<400>  3566
acuggcgcuu uuaucugauu acuuugagag ccaucaccag cgacuauguc guagugggua       60

aagcucccuc uucggaggga gcaucaaagg gccgagaugu cucgcuccg                  109


<210>  3567
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-2 microglobulin (B2M) non-target strand oligonucleotide

<400>  3567
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  3568
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  beta-2 microglobulin (B2M) target strand oligonucleotide

<400>  3568
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  3569
<211>  4667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pStX17 construct

<400>  3569
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct gcggcctcta gactcgaggc gttgacattg attattgact agttattaat      180

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac      240

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      300

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      360

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      420

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      480

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc      540

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      600

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      660

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      720

tctatataag cagagctctc tggctaacta ccggtgccac catggcccca aagaagaagc      780

ggaaggtcag ccaagagatc aagagaatca acaagatcag aaggagactg gtcaaggaca      840

gcaacacaaa gaaggccggc aagacaggcc ccatgaaaac cctgctcgtc agagtgatga      900

cccctgacct gagagagcgg ctggaaaacc tgagaaagaa gcccgagaac atccctcagc      960

ctatcagcaa caccagcagg gccaacctga acaagctgct gaccgactac accgagatga     1020

agaaagccat cctgcacgtg tactgggaag agttccagaa agaccccgtg ggcctgatga     1080

gcagagttgc tcagcccgct cctaagaaca tcgaccagag aaagctgatc cccgtgaagg     1140

acggcaacga gagactgacc tctagcggct ttgcctgcag ccagtgttgc cagcctctgt     1200

acgtgtacaa gctggaacaa gtgaacgaca agggcaagcc ccacaccaac tacttcggca     1260

gatgcaacgt gtccgagcac gagaggctga tcctgctgtc tcctcacaag cccgaggcca     1320

acgatgagct ggtcacatac agcctgggca agttcggaca gagagccctg gacttctaca     1380

gcatccacgt gaccagggag agcaatcacc ctgtgaagcc cctggaacag atcggcggca     1440

atagctgtgc ctctggacct gtgggaaaag ccctgagcga cgcctgtatg ggagccgtgg     1500

catccttcct gaccaagtac caggacatca tcctggaaca ccagaaagtg atcaagaaga     1560

acgagaaaag actggccaac ctcaaggata tcgccagcgc taacggcctg gcctttccta     1620

agatcaccct gcctccacag cctcacacca aagagggcat cgaggcctac aacaacgtgg     1680

tggcccagat cgtgatttgg gtcaacctga atctgtggca gaagctgaag atcggcaggg     1740

acgaagccaa gccactgcag agactgaagg gcttccctag cttccctctg gtggaaagac     1800

aggccaatga agtggattgg tgggacatgg tctgcaacgt gaagaagctg atcaacgaga     1860

agaaagagga tggcaaggtt ttctggcaga acctggccgg ctacaagaga caagaagccc     1920

tgctgcctta cctgagcagc gaagaggacc ggaagaaggg caagaagttc gccagatacc     1980

agttcggcga cctgctgctg cacctggaaa agaagcacgg cgaggactgg ggcaaagtgt     2040

acgatgaggc ctgggagaga atcgacaaga aggtggaagg cctgagcaag cacattaagc     2100

tggaagagga aagaaggagc gaggacgccc aatctaaagc cgctctgacc gattggctga     2160

gagccaaggc cagctttgtg atcgagggcc tgaaagaggc cgacaaggac gagttctgca     2220

gatgcgagct gaagctgcag aagtggtacg gcgatctgag aggcaagccc ttcgccattg     2280

aggccgagaa cagcatcctg gacatcagcg gcttcagcaa gcagtacaac tgcgccttca     2340

tttggcagaa agacggcgtc aagaaactga acctgtacct gatcatcaat tacttcaaag     2400

gcggcaagct gcggttcaag aagatcaaac ccgaggcctt cgaggctaac agattctaca     2460

ccgtgatcaa caaaaagtcc ggcgagatcg tgcccatgga agtgaacttc aacttcgacg     2520

accccaacct gattatcctg cctctggcct tcggcaagag acagggcaga gagttcatct     2580

ggaacgatct gctgagcctg gaaaccggct ctctgaagct ggccaatggc agagtgatcg     2640

agaaaaccct gtacaacagg agaaccagac aggacgagcc tgctctgttt gtggccctga     2700

ccttcgagag aagagaggtg ctggacagca gcaacatcaa gcccatgaac ctgatcggca     2760

tcgaccgggg cgagaatatc cctgctgtga tcgccctgac agaccctgaa ggatgcccac     2820

tgagcagatt caaggactcc ctgggcaacc ctacacacat cctgagaatc ggcgagagct     2880

acaaagagaa gcagaggaca atccaggccg ccaaagaggt ggaacagaga agagccggcg     2940

gatactctag gaagtacgcc agcaaggcca agaatctggc cgacgacatg gtccgaaaca     3000

ccgccagaga tctgctgtac tacgccgtga cacaggacgc catgctgatc ttcgagaatc     3060

tgagcagagg cttcggccgg cagggcaaga gaacctttat ggccgagagg cagtacacca     3120

gaatggaaga ttggctcaca gctaaactgg cctacgaggg actgcccagc aagacctacc     3180

tgtccaaaac actggcccag tatacctcca agacctgcag caattgcggc ttcaccatca     3240

ccagcgccga ctacgacaga gtgctggaaa agctcaagaa aaccgccacc ggctggatga     3300

ccaccatcaa cggcaaagag ctgaaggttg agggccagat cacctactac aacaggtaca     3360

agaggcagaa cgtcgtgaag gatctgagcg tggaactgga cagactgagc gaagagagcg     3420

tgaacaacga catcagcagc tggacaaagg gcagatcagg cgaggctctg agcctgctga     3480

agaagaggtt tagccacaga cctgtgcaag agaagttcgt gtgcctgaac tgcggcttcg     3540

agacacacgc cgatgaacag gctgccctga acattgccag aagctggctg ttcctgagaa     3600

gccaagagta caagaagtac cagaccaaca agaccaccgg caacaccgac aagagggcct     3660

ttgtggaaac ctggcagagc ttctacagaa aaaagctgaa agaagtctgg aagcccgccg     3720

tgactagtcc aaaaaagaag agaaaggtag attacaaaga tgacgatgac aaagactaca     3780

aggatgatga tgataaggga tcctacccat acgatgttcc agattacgct tacccatacg     3840

atgttccaga ttacgcttac ccatacgatg ttccagatta cgcttaagaa ttcctagagc     3900

tcgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     3960

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     4020

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     4080

cagcaagggg gaggattggg aagagaatag caggcatgct ggggaggtac cgtgagggcc     4140

tatttcccat gattccttca tatttgcata tacgatacaa ggctgttaga gagataattg     4200

gaattaattt gactgtaaac acaaagatat tagtacaaaa tacgtgacgt agaaagtaat     4260

aatttcttgg gtagtttgca gttttaaaat tatgttttaa aatggactat catatgctta     4320

ccgtaacttg aaagtatttc gatttcttgg ctttatatat cttgtggaaa ggacgaaaca     4380

ccgtactggc gcttttatct cattactttg agagccatca ccagcgacta tgtcgtatgg     4440

gtaaagcgct tatttatcgg agagaaatcc gataaataag aagcatcaaa ggggtcttcg     4500

agaagaccct tttttttggc ggccgcagga acccctagtg atggagttgg ccactccctc     4560

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4620

tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg                   4667


<210>  3570
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3570
gaggaggacg gcctggccga                                                   20


<210>  3571
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3571
accgctgcgc caaggtgcgg                                                   20


<210>  3572
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3572
gccaggccgt cctcctcgga                                                   20


<210>  3573
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3573
gtgctcgggt gcttcggcca                                                   20


<210>  3574
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3574
atggccttct tcctggcttc                                                   20


<210>  3575
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3575
gcaccaccac gtaggtgcca                                                   20


<210>  3576
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3576
tcctggcttc ctggtgaaga                                                   20


<210>  3577
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3577
tggcttcctg gtgaagatga                                                   20


<210>  3578
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3578
ccaggaagcc aggaagaagg                                                   20


<210>  3579
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3579
tccttgcatg gggccaggat                                                   20


<210>  3580
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3580
ggcggcaagt tctgctcagc                                                   20


<210>  3581
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3581
tctccacgat cgtcagcgtg                                                   20


<210>  3582
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3582
acgatcgtca gcgtgagtgc                                                   20


<210>  3583
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3583
ctctagcaat ggatcgtggg                                                   20


<210>  3584
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3584
caaacaaatg tgtcacaaag                                                   20


<210>  3585
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3585
gatgtgtata tcacagacaa                                                   20


<210>  3586
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3586
ggaataatgc tgttgttgaa                                                   20


<210>  3587
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3587
aaatccagtg acaagtctgt                                                   20


<210>  3588
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3588
aggccacagc actgttgctc                                                   20


<210>  3589
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3589
agaagacacc ttcttcccca                                                   20


<210>  3590
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3590
tccccagccc aggtaagggc                                                   20


<210>  3591
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3591
ccagcccagg taagggcagc                                                   20


<210>  3592
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3592
agtccctcaa gtccttccag                                                   20


<210>  3593
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3593
agcagcagca gcagcagcag                                                   20


<210>  3594
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3594
tcagccgccg ccgcaggcac                                                   20


<210>  3595
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3595
agggtcgcca tggcggtctc                                                   20


<210>  3596
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3596
tcagcttttc cagggtcgcc                                                   20


<210>  3597
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3597
gccgcagccg cccccgccgc                                                   20


<210>  3598
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3598
gccacagccg ggccgggtgg                                                   20


<210>  3599
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3599
tcagccacag ccgggccggg                                                   20


<210>  3600
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3600
cggtcggtgc agcggctcct                                                   20


<210>  3601
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3601
ccacaccttc actggtccat                                                   20


<210>  3602
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3602
taaaggaaag taatggacca                                                   20


<210>  3603
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3603
ctggtccatt actttccttt                                                   20


<210>  3604
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3604
tgagtttgga gataatacag                                                   20


<210>  3605
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3605
atagacacat cggccacacc                                                   20


<210>  3606
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3606
ttattaggca tgttggagac                                                   20


<210>  3607
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3607
caggagacca ttgcatcatt                                                   20


<210>  3608
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3608
ggcctggagg ctatccagcg                                                   20


<210>  3609
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3609
ggccgagatg tctcgctccg                                                   20


<210>  3610
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3610
aggccagaaa gagagagtag                                                   20


<210>  3611
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3611
cgctggatag cctccaggcc                                                   20


<210>  3612
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer sequence

<400>  3612
tgaagctgac agcattcggg                                                   20


<210>  3613
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oSH7

<400>  3613
aacacgtccg tcctagaact                                                   20


<210>  3614
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oSH8

<400>  3614
acttggttac gctcaacact                                                   20


<210>  3615
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer SAH24

<400>  3615
ttcaggttgg accggtgcca ccatggcccc aaagaagaag cggaaggtca gccaagagat       60

caagagaatc aacaagatca ga                                                82


<210>  3616
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer SAH25

<400>  3616
ttttggacta gtcacggcgg gcttccag                                          28


<210>  3617
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oIC539

<400>  3617
atggccccaa agaagaagcg gaaggtctct agacaag                                37


<210>  3618
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR primer oIC540

<400>  3618
tacctttctc ttcttttttg gactagtcac gg                                     32


<210>  3619
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR1 Fwd primer


<220>
<221>  misc_feature
<222>  (34)..(40)
<223>  n is any nucleotide

<400>  3619
acactctttc cctacacgac gctcttccga tctnnnnnnn                             40


<210>  3620
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2 Rvs primer

<400>  3620
gtgactggag ttcagacgtg tgctcttccg atct                                   34


<210>  3621
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2 Fwd primer

<400>  3621
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tc               52


<210>  3622
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2 Rvs v1 001 primer

<400>  3622
caagcagaag acggcatacg agatcgtgat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  3623
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Planctomyces reference guide scaffold from the plasmid backbone

<400>  3623
tgacagctag ctcagtccta ggtataatac tagttactgg cgcttttatc tcattacttt       60

gagagccatc accagcgact atgtcgtatg ggtaaagcgc ttatttatcg gagagaaatc      120

cgataaataa gaagcatcaa agctggagtt gtcccaattc ttctagag                   168


<210>  3624
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 4.76

<400>  3624
uguggucggg guagcggcug                                                   20


<210>  3625
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 4.77

<400>  3625
ucaaguccgc caugcccgaa                                                   20


<210>  3626
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 8.2

<400>  3626
auguucauga guuuggagau                                                   20


<210>  3627
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  spacer 8.4

<400>  3627
ucgccauaac ucgcuaggcc                                                   20


<210>  3628
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.13

<400>  3628
cagcattctt gggtgggagc                                                   20


<210>  3629
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.14

<400>  3629
tgggtgggag cagccacggg                                                   20


<210>  3630
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.15

<400>  3630
tggctgtggc ccttgtggct                                                   20


<210>  3631
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.16

<400>  3631
gtgccattca tggctgtggc                                                   20


<210>  3632
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.17

<400>  3632
acgtgccctt ctccaatgcg                                                   20


<210>  3633
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.18

<400>  3633
ccaatgcgac gggtgtggta                                                   20


<210>  3634
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.19

<400>  3634
agtacccaca gtactacctg                                                   20


<210>  3635
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.2

<400>  3635
ccatgctggc cgcctacatg                                                   20


<210>  3636
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.21

<400>  3636
gctgatcgtg ctgggcttcc                                                   20


<210>  3637
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.22

<400>  3637
ccatcaactt cctcacgctc                                                   20


<210>  3638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.23

<400>  3638
tcacgctcta cgtcaccgtc                                                   20


<210>  3639
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.24

<400>  3639
tgtgctggac ggtgacgtag                                                   20


<210>  3640
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.25

<400>  3640
tggtcctagg tggcttcacc                                                   20


<210>  3641
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.26

<400>  3641
ccagcaccct ctacacctct                                                   20


<210>  3642
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.27

<400>  3642
tcttcgggcc cacaggatgc                                                   20


<210>  3643
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.28

<400>  3643
ggcccacagg atgcaatttg                                                   20


<210>  3644
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.29

<400>  3644
ttgccaccct gggcggtatg                                                   20


<210>  3645
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer 11.1

<400>  3645
aaggggctgc gtaccacacc                                                   20


<210>  3646
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.13

<400>  3646
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc agcattcttg ggtgggagc                  109


<210>  3647
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.14

<400>  3647
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt gggtgggagc agccacggg                  109


<210>  3648
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.15

<400>  3648
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt ggctgtggcc cttgtggct                  109


<210>  3649
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.16

<400>  3649
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagg tgccattcat ggctgtggc                  109


<210>  3650
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.17

<400>  3650
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga cgtgcccttc tccaatgcg                  109


<210>  3651
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.18

<400>  3651
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc caatgcgacg ggtgtggta                  109


<210>  3652
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.19

<400>  3652
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga gtacccacag tactacctg                  109


<210>  3653
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.2

<400>  3653
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc catgctggcc gcctacatg                  109


<210>  3654
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.21

<400>  3654
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagg ctgatcgtgc tgggcttcc                  109


<210>  3655
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.22

<400>  3655
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc catcaacttc ctcacgctc                  109


<210>  3656
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.23

<400>  3656
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt cacgctctac gtcaccgtc                  109


<210>  3657
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.24

<400>  3657
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt gtgctggacg gtgacgtag                  109


<210>  3658
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.25

<400>  3658
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt ggtcctaggt ggcttcacc                  109


<210>  3659
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.26

<400>  3659
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagc cagcaccctc tacacctct                  109


<210>  3660
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.27

<400>  3660
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt cttcgggccc acaggatgc                  109


<210>  3661
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.28

<400>  3661
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagg gcccacagga tgcaatttg                  109


<210>  3662
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.29

<400>  3662
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaagt tgccaccctg ggcggtatg                  109


<210>  3663
<211>  109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  174 guide and spacer 11.1

<400>  3663
actggcgctt ttatctgatt actttgagag ccatcaccag cgactatgtc gtagtgggta       60

aagctccctc ttcggaggga gcatcaaaga aggggctgcg taccacacc                  109


<210>  3664
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3664

Val Ser Ser Lys Asp Leu 
1               5       


<210>  3665
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3665

Gly Ser Pro Gly Ile Lys 
1               5       


<210>  3666
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3666

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3667
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3667

Val Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3668
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3668

Gly Ser Pro Gly 
1               


<210>  3669
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3669

Val Ser Ser Lys 
1               


<210>  3670
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3670

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  3671
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3671

Val Ser Ser Lys Asp Leu Gln Ala 
1               5               


<210>  3672
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3672

Gly Ser Pro Gly Ile Lys 
1               5       


<210>  3673
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3673

Val Ser Ser Lys Asp 
1               5   


<210>  3674
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3674

Gly Ser Pro Gly Ile 
1               5   


<210>  3675
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3675

Val Ser Ser Lys Asp Leu Gln Ala Ser 
1               5                   


<210>  3676
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3676

Ile Lys Arg Ile Asn Lys 
1               5       


<210>  3677
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3677

Arg Arg Thr Arg Gln Asp Glu 
1               5           


<210>  3678
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3678

Val Ser Ser Lys Glu 
1               5   


<210>  3679
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3679

Glu Gly Gln Ile Thr Tyr Tyr 
1               5           


<210>  3680
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3680

Leu Ser Arg Phe Lys Asp 
1               5       


<210>  3681
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3681

Lys Lys His Gly Glu Asp 
1               5       


<210>  3682
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3682

Glu Gly Gln Ile 
1               


<210>  3683
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3683

Ser Lys Thr Tyr Leu 
1               5   


<210>  3684
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3684

Val Ser Ser Lys Asp Leu Arg Ala 
1               5               


<210>  3685
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3685

Pro Thr His Ile Leu 
1               5   


<210>  3686
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3686

Ser Leu Leu Lys Lys 
1               5   


<210>  3687
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3687

Gln Gly Arg Glu Phe Ile 
1               5       


<210>  3688
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3688

Glu Thr His Ala Asp Glu 
1               5       


<210>  3689
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3689

Ala Asp Asp Met Val Arg Asn 
1               5           


<210>  3690
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3690

Glu Gly Gln Ile Thr Tyr 
1               5       


<210>  3691
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3691

Val Ser Ser Lys Asp Leu Arg 
1               5           


<210>  3692
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3692

Gly Gln Arg Ala Leu Asp Phe Tyr 
1               5               


<210>  3693
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3693

Arg Arg Thr Arg Gln Asp 
1               5       


<210>  3694
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3694

Ala Leu Leu Pro Tyr 
1               5   


<210>  3695
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3695

Gly Tyr Ser Arg 
1               


<210>  3696
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3696

Asp Arg Lys Lys 
1               


<210>  3697
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3697

Arg Cys Asn Val Ser 
1               5   


<210>  3698
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3698

Arg Cys Glu Leu Lys 
1               5   


<210>  3699
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3699

Ser Phe Ser Ser His 
1               5   


<210>  3700
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3700

Leu Asn Leu Tyr 
1               


<210>  3701
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3701

Val Lys Asp Leu Ser 
1               5   


<210>  3702
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3702

Arg Cys Asn Val 
1               


<210>  3703
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3703

Arg Cys Asn Val Ser Glu His Glu 
1               5               


<210>  3704
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3704

Arg Arg Thr Arg 
1               


<210>  3705
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3705

Gln Ala Ala Leu Asn 
1               5   


<210>  3706
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3706

Val Ser Ser Lys Asp Leu Glu 
1               5           


<210>  3707
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3707

Thr Leu Pro Pro Gln Pro His 
1               5           


<210>  3708
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3708

Ser Leu Leu Lys Lys Arg 
1               5       


<210>  3709
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3709

Ala Asn Arg Phe Tyr 
1               5   


<210>  3710
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3710

Leu Ala Asn Gly Arg 
1               5   


<210>  3711
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3711

Asp Ala Cys Met 
1               


<210>  3712
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3712

Glu Val Leu Asp 
1               


<210>  3713
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3713

Arg Cys Asn Val Ser Glu 
1               5       


<210>  3714
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3714

Val Ser Ser Lys Asp Gln 
1               5       


<210>  3715
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3715

Gly Gly Asn Ser Cys Ala 
1               5       


<210>  3716
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3716

Arg Phe Tyr Thr 
1               


<210>  3717
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3717

Glu Thr Trp Gln Ser Phe Tyr 
1               5           


<210>  3718
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3718

Thr Asp Lys Arg Ala Phe Val Glu 
1               5               


<210>  3719
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3719

Asn Arg Tyr Lys Arg Gln 
1               5       


<210>  3720
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3720

Gly Val Lys Lys Leu Asn Leu Tyr 
1               5               


<210>  3721
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3721

Pro Thr His Ile Leu Arg 
1               5       


<210>  3722
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3722

Gly Asn Thr Asp Lys Arg Ala 
1               5           


<210>  3723
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3723

Lys Gly Lys Pro His 
1               5   


<210>  3724
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3724

Gly Gly Asn Ser Cys Ala Ser Gly 
1               5               


<210>  3725
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3725

Gly Lys Pro His Thr Asn Tyr 
1               5           


<210>  3726
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3726

Ile Phe Glu Asn Leu Ser 
1               5       


<210>  3727
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3727

Ser Leu Leu Lys 
1               


<210>  3728
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3728

Glu Thr His Ala Ala 
1               5   


<210>  3729
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3729

Leu Glu Thr Gly Ser Leu Lys 
1               5           


<210>  3730
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3730

Leu Ser Arg Phe Lys Asp Ser 
1               5           


<210>  3731
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3731

Gly Lys Pro His Thr 
1               5   


<210>  3732
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3732

Thr Lys Tyr Gln Asp 
1               5   


<210>  3733
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3733

Asn Ser Ile Leu Asp 
1               5   


<210>  3734
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3734

Glu Glu Arg Arg 
1               


<210>  3735
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3735

Lys Leu Asn Leu Tyr Leu 
1               5       


<210>  3736
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3736

Pro Thr His Ile 
1               


<210>  3737
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3737

Glu Thr Trp Gln Ser 
1               5   


<210>  3738
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3738

Ser Lys Gln Tyr Asn 
1               5   


<210>  3739
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3739

Asn Pro Thr His Ile Leu Arg 
1               5           


<210>  3740
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3740

Asp Leu Ser Val Glu Leu 
1               5       


<210>  3741
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3741

Ser Asn Ile Lys 
1               


<210>  3742
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3742

Lys Lys His Gly Glu Asp Trp Gly 
1               5               


<210>  3743
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3743

Arg Ser Thr Ala Arg Thr Gly Ala 
1               5               


<210>  3744
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3744

Glu Arg Ile Asp Lys Lys Val 
1               5           


<210>  3745
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3745

Val Cys Asn Val Lys Lys 
1               5       


<210>  3746
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3746

Glu Arg Arg Glu Val Leu Asp 
1               5           


<210>  3747
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3747

Gln Lys Asp Gly Val Lys 
1               5       


<210>  3748
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3748

Leu Ser Glu Glu 
1               


<210>  3749
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3749

Val Ile Glu Lys 
1               


<210>  3750
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3750

Phe Glu Thr His Ala Ala Glu Gln Ala 
1               5                   


<210>  3751
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3751

Gln Ile Gly Gly Asn Ser 
1               5       


<210>  3752
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3752

Lys Pro Ala Val 
1               


<210>  3753
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3753

Asp Ala Cys Met Gly 
1               5   


<210>  3754
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3754

Asp Trp Gly Lys Val Tyr 
1               5       


<210>  3755
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3755

Gly Lys Arg Gln 
1               


<210>  3756
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3756

Ala Asn Leu Lys Asp Ile 
1               5       


<210>  3757
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3757

Ser Lys Thr Leu Ala Gln Tyr Thr 
1               5               


<210>  3758
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3758

Thr Phe Glu Arg 
1               


<210>  3759
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3759

Leu Gly Asn Pro Thr 
1               5   


<210>  3760
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3760

Val Cys Leu Asn 
1               


<210>  3761
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3761

Val Val Lys Asp Leu Ser Val Glu 
1               5               


<210>  3762
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3762

Gly Arg Ile Ile 
1               


<210>  3763
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3763

Asn Ser Ser Leu 
1               


<210>  3764
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3764

Thr His Ala Ala Glu Gln 
1               5       


<210>  3765
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3765

Leu Ala Asn Gly Arg Val Ile Glu 
1               5               


<210>  3766
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3766

Thr Thr Ile Asn 
1               


<210>  3767
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3767

Ala Lys Glu Val Glu Gln Arg 
1               5           


<210>  3768
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3768

Lys Leu Gln Lys 
1               


<210>  3769
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3769

Thr His Ala Ala Glu Gln Ala 
1               5           


<210>  3770
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3770

Ile Gln Ala Ala Lys Glu 
1               5       


<210>  3771
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3771

Gln Arg Ala Leu Asp Phe Tyr 
1               5           


<210>  3772
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3772

Pro Glu Ala Asn Asp Glu 
1               5       


<210>  3773
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3773

Glu Thr His Ala Ala Glu 
1               5       


<210>  3774
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3774

Arg Ser Trp Leu Phe Leu 
1               5       


<210>  3775
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3775

Arg Ser Trp Leu Phe Leu 
1               5       


<210>  3776
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3776

Ala Glu Gln Ala Ala Leu Asn 
1               5           


<210>  3777
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3777

Gly Lys Pro His Thr Asn Tyr Phe 
1               5               


<210>  3778
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3778

Val Lys Lys Leu Asn 
1               5   


<210>  3779
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3779

Ala Asp Asp Met 
1               


<210>  3780
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3780

Val Ser Ser Lys Asp Leu Lys 
1               5           


<210>  3781
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3781

Thr Lys Tyr Gln 
1               


<210>  3782
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3782

Ser His Arg Pro Val Gln Glu 
1               5           


<210>  3783
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3783

Ala Leu Asp Phe Tyr 
1               5   


<210>  3784
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3784

Leu Thr Ala Lys Leu Ala 
1               5       


<210>  3785
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3785

Lys Thr Leu Ala Gln Tyr Thr 
1               5           


<210>  3786
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3786

Asn Arg Phe Tyr Thr Val Ile 
1               5           


<210>  3787
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3787

Lys Pro Met Asn 
1               


<210>  3788
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3788

Thr Asn Tyr Phe Gly 
1               5   


<210>  3789
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3789

Ser Leu Gly Lys Phe Gly Gln 
1               5           


<210>  3790
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3790

Gln Thr Asn Lys 
1               


<210>  3791
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3791

Ile Pro Ala Val 
1               


<210>  3792
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3792

Glu Val Leu Asp Ser Ser Asn 
1               5           


<210>  3793
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3793

Lys Lys Val Glu Gly Leu Ser 
1               5           


<210>  3794
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3794

Asn Val Ser Glu His Glu Arg 
1               5           


<210>  3795
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3795

Pro Ser Lys Thr Tyr 
1               5   


<210>  3796
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3796

Ala Asp Lys Asp Glu Phe Cys 
1               5           


<210>  3797
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3797

Val Glu Gly Gln 
1               


<210>  3798
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3798

Ala Asp Asp Met Val 
1               5   


<210>  3799
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3799

Tyr Tyr Ala Val Thr Gln 
1               5       


<210>  3800
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3800

Ala Leu Ser Asp Ala 
1               5   


<210>  3801
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3801

Ala Tyr Glu Gly 
1               


<210>  3802
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3802

Asp Leu Leu Tyr 
1               


<210>  3803
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3803

Glu Ala Phe Glu 
1               


<210>  3804
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3804

Glu Ala Trp Glu Arg Ile Asp Lys Lys Val 
1               5                   10  


<210>  3805
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3805

Glu Leu Asp Arg 
1               


<210>  3806
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3806

Phe Met Ala Glu Arg Gln Tyr 
1               5           


<210>  3807
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3807

Phe Val Ala Leu 
1               


<210>  3808
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3808

Gly Cys Pro Leu 
1               


<210>  3809
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3809

Gly Gly Lys Leu Arg Phe Lys 
1               5           


<210>  3810
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3810

Gly Lys Phe Gly Gln Arg Ala Leu Asp Phe Tyr 
1               5                   10      


<210>  3811
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3811

Gly Asn Pro Thr 
1               


<210>  3812
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3812

His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
1               5                   10  


<210>  3813
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3813

Ile Leu Arg Ile 
1               


<210>  3814
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3814

Lys Asp Ser Asn Thr Lys Lys 
1               5           


<210>  3815
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3815

Lys Gly Phe Pro Ser 
1               5   


<210>  3816
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3816

Lys Lys His Gly Glu 
1               5   


<210>  3817
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3817

Lys Pro Leu Gln Arg Leu 
1               5       


<210>  3818
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3818

Lys Gln Tyr Asn Cys Ala 
1               5       


<210>  3819
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3819

Lys Ser Gly Glu Ile 
1               5   


<210>  3820
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3820

Lys Trp Tyr Gly 
1               


<210>  3821
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3821

Lys Trp Tyr Gly Asp 
1               5   


<210>  3822
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3822

Lys Trp Tyr Gly Asp Leu 
1               5       


<210>  3823
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3823

Leu Asp Phe Tyr Ser Ile His 
1               5           


<210>  3824
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3824

Leu Asp Phe Tyr Ser Ile His Val 
1               5               


<210>  3825
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3825

Leu Glu Gln Ile Gly 
1               5   


<210>  3826
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3826

Leu Glu Gln Ile Gly Gly 
1               5       


<210>  3827
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3827

Asn Cys Gly Phe Glu Thr 
1               5       


<210>  3828
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3828

Asn Leu Tyr Leu 
1               


<210>  3829
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3829

Pro Lys Ile Thr Leu Pro 
1               5       


<210>  3830
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3830

Arg Ile Asp Lys Lys Val 
1               5       


<210>  3831
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3831

Ser Glu Asp Ala Gln Ser 
1               5       


<210>  3832
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3832

Thr Gly Trp Met 
1               


<210>  3833
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3833

Thr Ile Asn Gly 
1               


<210>  3834
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3834

Thr Leu Tyr Asn 
1               


<210>  3835
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3835

Thr Leu Tyr Asn Arg Arg Thr Arg 
1               5               


<210>  3836
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3836

Val Ala Gln Ile Val 
1               5   


<210>  3837
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3837

Val Lys Asp Ser Asn Thr Lys 
1               5           


<210>  3838
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3838

Val Thr Tyr Ser 
1               


<210>  3839
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3839

Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln 
1               5                   10  


<210>  3840
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant reference

<400>  3840

Val Tyr Asp Glu Ala Trp Glu 
1               5           


<210>  3841
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3841

Ala Ala Glu Gln 
1               


<210>  3842
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3842

Ala Ala Glu Gln Ala 
1               5   


<210>  3843
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3843

Ala Ala Lys Glu Val Glu Gln Arg 
1               5               


<210>  3844
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3844

Ala Ala Ser Cys Gly Ser Arg 
1               5           


<210>  3845
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3845

Ala Asp Asp Met Val Arg 
1               5       


<210>  3846
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3846

Ala Asp Tyr Asp 
1               


<210>  3847
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3847

Ala Glu Arg Gln Tyr 
1               5   


<210>  3848
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3848

Ala Phe Glu Ala Asn Arg Phe Tyr 
1               5               


<210>  3849
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3849

Ala Phe Gly Lys 
1               


<210>  3850
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3850

Ala Phe Gly Lys Arg Gln Gly 
1               5           


<210>  3851
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3851

Ala Gly Tyr Lys Arg Gln 
1               5       


<210>  3852
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3852

Ala Lys Asn Leu 
1               


<210>  3853
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3853

Ala Lys Pro Leu Gln Arg Leu Lys 
1               5               


<210>  3854
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3854

Ala Leu Leu Pro 
1               


<210>  3855
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3855

Ala Leu Asn Ile 
1               


<210>  3856
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3856

Ala Leu Ser Asp Ala Cys Met 
1               5           


<210>  3857
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3857

Ala Leu Thr Asp 
1               


<210>  3858
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3858

Ala Leu Thr Asp Pro Glu 
1               5       


<210>  3859
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3859

Ala Leu Thr Asp Trp Leu Arg 
1               5           


<210>  3860
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3860

Ala Asn Leu Ser 
1               


<210>  3861
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3861

Ala Gln Ile Val Ile Trp 
1               5       


<210>  3862
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3862

Ala Gln Ser Lys 
1               


<210>  3863
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3863

Ala Ser Gly Pro Val Gly 
1               5       


<210>  3864
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3864

Ala Ser Ser Asp Arg Glu Pro Trp Thr Ser Thr 
1               5                   10      


<210>  3865
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3865

Ala Ser Ser Lys 
1               


<210>  3866
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3866

Ala Ser Ser Lys Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  3867
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3867

Ala Thr Leu His 
1               


<210>  3868
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3868

Ala Val Thr Gln 
1               


<210>  3869
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3869

Ala Val Thr Gln Asp 
1               5   


<210>  3870
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3870

Ala Trp Glu Arg Ile Asp Lys 
1               5           


<210>  3871
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3871

Ala Tyr Asn Asn Val 
1               5   


<210>  3872
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3872

Cys Asn Val Ser Glu 
1               5   


<210>  3873
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3873

Cys Thr Met Arg Pro Gly 
1               5       


<210>  3874
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3874

Asp Ala Cys Met Gly Ala Val 
1               5           


<210>  3875
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3875

Asp Ala Gln Ser Lys 
1               5   


<210>  3876
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3876

Asp Asp Met Val 
1               


<210>  3877
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3877

Asp Asp Pro Asn Leu Ile Ile 
1               5           


<210>  3878
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3878

Asp Glu Ala Trp 
1               


<210>  3879
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3879

Asp Glu Ala Trp Glu 
1               5   


<210>  3880
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3880

Asp Glu Ala Trp Glu Arg Ile Asp 
1               5               


<210>  3881
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3881

Asp Glu Phe Cys Arg 
1               5   


<210>  3882
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3882

Asp Glu Phe Cys Arg Cys Glu 
1               5           


<210>  3883
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3883

Asp Glu Leu Val 
1               


<210>  3884
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3884

Asp Phe Tyr Ser Ile 
1               5   


<210>  3885
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3885

Asp Phe Tyr Ser Ile His 
1               5       


<210>  3886
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3886

Asp His Ser Arg Asp 
1               5   


<210>  3887
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3887

Asp Ile Ser Gly 
1               


<210>  3888
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3888

Asp Ile Ser Gly Phe Ser 
1               5       


<210>  3889
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3889

Asp Ile Ser Ser 
1               


<210>  3890
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3890

Asp Lys Arg Ala 
1               


<210>  3891
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3891

Asp Lys Arg Ala Phe Val 
1               5       


<210>  3892
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3892

Asp Leu Leu Leu His 
1               5   


<210>  3893
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3893

Asp Leu Leu Leu His Leu 
1               5       


<210>  3894
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3894

Asp Leu Leu Ser 
1               


<210>  3895
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3895

Asp Leu Leu Ser Leu Glu 
1               5       


<210>  3896
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3896

Asp Met Val Cys 
1               


<210>  3897
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3897

Asp Asn Gln Val 
1               


<210>  3898
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3898

Asp Asn Gln Val Gly 
1               5   


<210>  3899
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3899

Asp Tyr Asp Arg Val Leu Glu 
1               5           


<210>  3900
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3900

Glu Ala Ala Val Gln Ala 
1               5       


<210>  3901
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3901

Glu Ala Asp Lys Asp Glu Phe Cys 
1               5               


<210>  3902
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3902

Glu Ala Glu Asn Ser Ile Leu 
1               5           


<210>  3903
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3903

Glu Ala Gly Cys Ser 
1               5   


<210>  3904
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3904

Glu Ala Asn Asp Glu 
1               5   


<210>  3905
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3905

Glu Ala Trp Glu 
1               


<210>  3906
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3906

Glu Ala Trp Glu Arg 
1               5   


<210>  3907
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3907

Glu Glu Glu Arg Arg Ser 
1               5       


<210>  3908
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3908

Glu Glu Arg Arg Ser 
1               5   


<210>  3909
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3909

Glu Phe Cys Arg Cys 
1               5   


<210>  3910
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3910

Glu Gly Leu Ser 
1               


<210>  3911
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3911

Glu Gly Gln Ile Thr 
1               5   


<210>  3912
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3912

Glu Gly Gln Ile Thr Tyr Tyr Asn 
1               5               


<210>  3913
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3913

Glu His Glu Arg Leu Ile 
1               5       


<210>  3914
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3914

Glu Lys Lys Glu Asp 
1               5   


<210>  3915
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3915

Glu Lys Lys His Gly 
1               5   


<210>  3916
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3916

Glu Arg Leu Ile 
1               


<210>  3917
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3917

Glu Ser Asn His Pro Val 
1               5       


<210>  3918
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3918

Glu Ser Val Asn Asn Asp 
1               5       


<210>  3919
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3919

Glu Thr His Ala 
1               


<210>  3920
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3920

Glu Val Leu Asp Ser 
1               5   


<210>  3921
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3921

Glu Val Asn Phe Asn 
1               5   


<210>  3922
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3922

Phe Ala Ile Glu Ala Glu Asn 
1               5           


<210>  3923
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3923

Phe Glu Arg Arg Glu 
1               5   


<210>  3924
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3924

Phe Gly Lys Arg Gln Gly 
1               5       


<210>  3925
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3925

Phe Gly Gln Arg Ala Leu Asp 
1               5           


<210>  3926
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3926

Phe Ile Trp Asn 
1               


<210>  3927
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3927

Phe Ile Trp Asn Asp Leu Leu 
1               5           


<210>  3928
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3928

Phe Pro Ser Phe Pro Leu Val 
1               5           


<210>  3929
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3929

Phe Ser Lys Gln Tyr Asn 
1               5       


<210>  3930
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3930

Phe Ser Lys Gln Tyr Asn Cys Ala 
1               5               


<210>  3931
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3931

Phe Ser Ser Lys 
1               


<210>  3932
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3932

Phe Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3933
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3933

Phe Ser Ser Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  3934
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3934

Phe Val Cys Leu Asn 
1               5   


<210>  3935
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3935

Phe Tyr Arg Lys Lys 
1               5   


<210>  3936
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3936

Gly Ala Val Ala Ser Phe 
1               5       


<210>  3937
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3937

Gly Cys Pro Leu Ser Arg 
1               5       


<210>  3938
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3938

Gly Cys Pro Leu Ser Arg Phe Lys 
1               5               


<210>  3939
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3939

Gly Asp Leu Leu Leu His 
1               5       


<210>  3940
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3940

Gly Asp Leu Arg 
1               


<210>  3941
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3941

Gly Asp Leu Arg Gly Lys 
1               5       


<210>  3942
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3942

Gly Asp Leu Arg Gly Lys Pro 
1               5           


<210>  3943
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3943

Gly Phe Ser Lys Gln Tyr Asn 
1               5           


<210>  3944
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3944

Gly Lys Glu Leu Lys Val Glu 
1               5           


<210>  3945
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3945

Gly Lys Phe Gly Gln 
1               5   


<210>  3946
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3946

Gly Lys Phe Gly Gln Arg 
1               5       


<210>  3947
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3947

Gly Lys Pro His Thr Asn 
1               5       


<210>  3948
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3948

Gly Lys Val Tyr Asp Glu Ala Trp Glu 
1               5                   


<210>  3949
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3949

Gly Leu Ala Phe Pro Lys 
1               5       


<210>  3950
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3950

Gly Leu Lys Glu Ala Asp Lys 
1               5           


<210>  3951
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3951

Gly Leu Pro Ser Lys 
1               5   


<210>  3952
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3952

Gly Asn Thr Asp 
1               


<210>  3953
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3953

Gly Asn Thr Asp Lys 
1               5   


<210>  3954
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3954

Gly Arg Glu Phe Ile 
1               5   


<210>  3955
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3955

Gly Arg Glu Phe Ile Trp 
1               5       


<210>  3956
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3956

Gly Arg Ser Gly Glu Ala 
1               5       


<210>  3957
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3957

Gly Arg Ser Gly Glu Ala Leu 
1               5           


<210>  3958
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3958

Gly Ser Leu Lys Leu Ala Asn 
1               5           


<210>  3959
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3959

Gly Tyr Lys Arg Gln 
1               5   


<210>  3960
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3960

Gly Tyr Ser Arg Lys 
1               5   


<210>  3961
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3961

Gly Tyr Ser Arg Lys Tyr Ala Ser 
1               5               


<210>  3962
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3962

His Glu Arg Leu Ile Leu Leu 
1               5           


<210>  3963
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3963

His Ile Lys Leu Glu 
1               5   


<210>  3964
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3964

His Arg Pro Val 
1               


<210>  3965
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3965

His Thr Lys Glu 
1               


<210>  3966
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3966

His Thr Lys Glu Gly 
1               5   


<210>  3967
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3967

His Thr Lys Glu Gly Ile Glu 
1               5           


<210>  3968
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3968

Ile Ala Arg Gly Glu 
1               5   


<210>  3969
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3969

Ile Asp Arg Gly Glu Asn 
1               5       


<210>  3970
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3970

Ile Glu Ala Glu Asn Ser 
1               5       


<210>  3971
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3971

Ile Glu Ala Glu Asn Ser Ile 
1               5           


<210>  3972
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3972

Ile Glu Ala Glu Asn Ser Ile Leu Asp 
1               5                   


<210>  3973
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3973

Ile Glu Lys Thr Leu Tyr Asn 
1               5           


<210>  3974
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3974

Ile Phe Ala Asn Leu Ser 
1               5       


<210>  3975
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3975

Ile Phe Ala Asn Leu Ser Arg 
1               5           


<210>  3976
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3976

Ile Leu Glu His Gln Lys 
1               5       


<210>  3977
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3977

Ile Asn Gly Lys Glu Leu Lys 
1               5           


<210>  3978
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3978

Ile Asn Tyr Phe Lys 
1               5   


<210>  3979
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3979

Ile Gln Ala Ala Lys 
1               5   


<210>  3980
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3980

Ile Ser Ser Lys Asp Leu Gln 
1               5           


<210>  3981
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3981

Ile Thr Tyr Tyr 
1               


<210>  3982
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3982

Ile Thr Tyr Tyr Asn 
1               5   


<210>  3983
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3983

Ile Trp Asn Asp 
1               


<210>  3984
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3984

Ile Trp Asn Asp Leu Leu 
1               5       


<210>  3985
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3985

Ile Trp Gln Lys Asp 
1               5   


<210>  3986
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3986

Lys Asp Ser Leu Gly 
1               5   


<210>  3987
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3987

Lys Glu Ala Asp 
1               


<210>  3988
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3988

Lys Glu Ala Asp Lys Asp Glu 
1               5           


<210>  3989
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3989

Lys Glu Asp Gly 
1               


<210>  3990
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3990

Lys Glu Val Glu Gln Arg 
1               5       


<210>  3991
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3991

Lys Gly Lys Pro His Thr Asn 
1               5           


<210>  3992
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3992

Lys Gly Lys Pro His Thr Asn Tyr 
1               5               


<210>  3993
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3993

Lys His Gly Glu Asp 
1               5   


<210>  3994
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3994

Lys Lys Gly Lys 
1               


<210>  3995
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3995

Lys Lys Gly Lys Lys 
1               5   


<210>  3996
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3996

Lys Lys Ile Lys 
1               


<210>  3997
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3997

Lys Lys Leu Ile 
1               


<210>  3998
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3998

Lys Lys Leu Ile Asn Glu 
1               5       


<210>  3999
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  3999

Lys Lys Leu Lys Glu Val Trp 
1               5           


<210>  4000
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4000

Lys Lys Asn Glu 
1               


<210>  4001
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4001

Lys Lys Val Glu 
1               


<210>  4002
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4002

Lys Lys Tyr Gln Thr Asn 
1               5       


<210>  4003
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4003

Lys Leu Lys Ile Gly Arg Asp Glu Ala 
1               5                   


<210>  4004
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4004

Lys Leu Lys Lys 
1               


<210>  4005
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4005

Lys Leu Asn Leu 
1               


<210>  4006
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4006

Lys Leu Gln Lys Trp 
1               5   


<210>  4007
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4007

Lys Leu Arg Phe 
1               


<210>  4008
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4008

Lys Leu Arg Phe Lys 
1               5   


<210>  4009
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4009

Lys Asn Glu Lys Arg 
1               5   


<210>  4010
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4010

Lys Pro Glu Ala 
1               


<210>  4011
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4011

Lys Pro His Thr 
1               


<210>  4012
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4012

Lys Pro His Thr Asn Tyr 
1               5       


<210>  4013
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4013

Lys Pro His Thr Asn Tyr Phe 
1               5           


<210>  4014
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4014

Lys Pro Met Asn Leu Ile Gly 
1               5           


<210>  4015
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4015

Lys Gln Tyr Asn 
1               


<210>  4016
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4016

Lys Gln Tyr Asn Cys 
1               5   


<210>  4017
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4017

Lys Arg Leu Ala 
1               


<210>  4018
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4018

Lys Arg Leu Ala Asn Leu Lys Asp 
1               5               


<210>  4019
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4019

Lys Arg Gln Gly Arg 
1               5   


<210>  4020
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4020

Lys Thr Tyr Leu Ser Lys Thr 
1               5           


<210>  4021
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4021

Lys Val Glu Gly Gln Ile 
1               5       


<210>  4022
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4022

Lys Tyr Gln Asp Ile Ile Leu Glu 
1               5               


<210>  4023
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4023

Leu Ala Phe Gly Lys Arg 
1               5       


<210>  4024
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4024

Leu Ala Phe Pro Lys Ile Thr 
1               5           


<210>  4025
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4025

Leu Ala Asn Gly Arg Val 
1               5       


<210>  4026
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4026

Leu Ala Asn Leu Lys Asp 
1               5       


<210>  4027
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4027

Leu Ala Gln Tyr 
1               


<210>  4028
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4028

Leu Ala Tyr Glu 
1               


<210>  4029
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4029

Leu Asp Phe Tyr Ser Ile His Val Thr 
1               5                   


<210>  4030
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4030

Leu Glu Gln Ile 
1               


<210>  4031
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4031

Leu Glu Gln Ile Gly 
1               5   


<210>  4032
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4032

Leu Phe Leu Arg 
1               


<210>  4033
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4033

Leu Gly Lys Phe Gly Gln Arg 
1               5           


<210>  4034
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4034

Leu Gly Lys Phe Gly Gln Arg Ala 
1               5               


<210>  4035
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4035

Leu Gly Asn Pro Thr His Ile 
1               5           


<210>  4036
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4036

Leu His Leu Glu 
1               


<210>  4037
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4037

Leu His Leu Glu Lys 
1               5   


<210>  4038
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4038

Leu His Leu Glu Lys Lys His 
1               5           


<210>  4039
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4039

Leu Ile Asn Glu Lys Lys Glu 
1               5           


<210>  4040
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4040

Leu Lys Glu Ala Asp 
1               5   


<210>  4041
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4041

Leu Lys Glu Ala Asp Lys Asp 
1               5           


<210>  4042
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4042

Leu Lys Gly Phe Pro 
1               5   


<210>  4043
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4043

Leu Lys Val Glu Gly Gln Ile 
1               5           


<210>  4044
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4044

Leu Leu Pro Tyr 
1               


<210>  4045
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4045

Leu Leu Ser Pro His 
1               5   


<210>  4046
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4046

Leu Leu Ser Pro His Lys 
1               5       


<210>  4047
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4047

Leu Leu Tyr Tyr 
1               


<210>  4048
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4048

Leu Asn Leu Tyr Leu 
1               5   


<210>  4049
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4049

Leu Asn Leu Tyr Leu Ile 
1               5       


<210>  4050
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4050

Leu Pro Leu Ala 
1               


<210>  4051
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4051

Leu Pro Pro Gln 
1               


<210>  4052
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4052

Leu Pro Ser Lys Thr Tyr 
1               5       


<210>  4053
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4053

Leu Pro Tyr Leu Ser Ser Glu 
1               5           


<210>  4054
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4054

Leu Arg Ser Pro Cys Leu 
1               5       


<210>  4055
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4055

Leu Ser Asp Ala Cys Met Gly 
1               5           


<210>  4056
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4056

Leu Ser Glu Glu Ser Val Asn 
1               5           


<210>  4057
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4057

Leu Ser Lys Thr Leu Ala 
1               5       


<210>  4058
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4058

Leu Ser Lys Thr Leu Ala Gln Tyr Thr 
1               5                   


<210>  4059
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4059

Leu Ser Leu Glu Thr Gly Ser 
1               5           


<210>  4060
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4060

Leu Ser Val Glu Leu Asp Arg 
1               5           


<210>  4061
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4061

Leu Thr Lys Tyr 
1               


<210>  4062
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4062

Leu Trp Pro Arg Gly Ser Thr 
1               5           


<210>  4063
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4063

Leu Trp Gln Lys Leu Lys 
1               5       


<210>  4064
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4064

Met Ala Glu Arg Gln Tyr 
1               5       


<210>  4065
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4065

Met Val Arg Asn 
1               


<210>  4066
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4066

Met Val Arg Asn Thr Ala Arg 
1               5           


<210>  4067
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4067

Asn Cys Ala Phe 
1               


<210>  4068
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4068

Asn Cys Ala Phe Ile Trp 
1               5       


<210>  4069
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4069

Asn Cys Ala Phe Ile Trp Gln Lys 
1               5               


<210>  4070
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4070

Asn Asp Ile Ser Ser Trp Thr 
1               5           


<210>  4071
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4071

Asn Glu Lys Arg Leu Ala 
1               5       


<210>  4072
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4072

Asn Gly Leu Ala Phe Pro Lys 
1               5           


<210>  4073
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4073

Asn Ile Ala Arg 
1               


<210>  4074
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4074

Asn Leu Ser Arg 
1               


<210>  4075
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4075

Asn Ser Ser Leu Ser Ala 
1               5       


<210>  4076
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4076

Asn Ser Ser Leu Ser Ala Ser Phe 
1               5               


<210>  4077
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4077

Asn Ser Ser Leu Ser Ala Ser Phe 
1               5               


<210>  4078
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4078

Asn Thr Asp Lys 
1               


<210>  4079
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4079

Asn Val Lys Lys Leu Ile Asn 
1               5           


<210>  4080
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4080

Asn Val Val Ala Gln 
1               5   


<210>  4081
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4081

Asn Val Val Ala Gln Ile 
1               5       


<210>  4082
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4082

Asn Tyr Phe Lys 
1               


<210>  4083
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4083

Pro Ala Leu Phe 
1               


<210>  4084
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4084

Pro Ala Val Ile Ala Leu 
1               5       


<210>  4085
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4085

Pro Ala Val Ile Ala Leu Thr 
1               5           


<210>  4086
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4086

Pro Cys Thr Thr Gly Glu Pro Asp 
1               5               


<210>  4087
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4087

Pro Glu Ala Phe Glu 
1               5   


<210>  4088
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4088

Pro Glu Ala Phe Glu Ala Asn 
1               5           


<210>  4089
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4089

Pro His Thr Lys 
1               


<210>  4090
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4090

Pro His Thr Lys Glu 
1               5   


<210>  4091
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4091

Pro Met Asn Leu 
1               


<210>  4092
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4092

Pro Met Asn Leu Ile 
1               5   


<210>  4093
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4093

Pro Pro Leu Leu 
1               


<210>  4094
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4094

Pro Arg Leu Tyr 
1               


<210>  4095
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4095

Pro Ser Thr Ala 
1               


<210>  4096
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4096

Pro Thr His Ile Leu Arg Ile 
1               5           


<210>  4097
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4097

Pro Thr Arg Asp 
1               


<210>  4098
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4098

Pro Val Lys Pro Leu Glu 
1               5       


<210>  4099
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4099

Gln Asp Ala Met Leu Ile 
1               5       


<210>  4100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4100

Gln Asp Glu Pro Ala Leu Phe 
1               5           


<210>  4101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4101

Gln Gly Lys Arg Thr Phe Met 
1               5           


<210>  4102
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4102

Gln Gly Arg Glu 
1               


<210>  4103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4103

Gln Gly Arg Glu Phe Ile Trp Asn 
1               5               


<210>  4104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4104

Gln Ile Gly Gly Asn 
1               5   


<210>  4105
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4105

Gln Ile Thr Tyr Tyr Asn 
1               5       


<210>  4106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4106

Gln Lys Val Ile Lys 
1               5   


<210>  4107
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4107

Gln Asn Val Val Lys 
1               5   


<210>  4108
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4108

Gln Asn Val Val Lys Asp 
1               5       


<210>  4109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4109

Gln Arg Ala Leu Asp 
1               5   


<210>  4110
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4110

Gln Arg Ala Leu Asp Phe Tyr Ser 
1               5               


<210>  4111
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4111

Gln Arg Leu Lys 
1               


<210>  4112
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4112

Gln Arg Thr Ile 
1               


<210>  4113
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4113

Gln Arg Thr Ile Gln Ala 
1               5       


<210>  4114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4114

Gln Ser Phe Tyr Arg Lys Lys 
1               5           


<210>  4115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4115

Gln Thr Asn Lys Thr 
1               5   


<210>  4116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4116

Gln Thr Asn Lys Thr Thr Gly 
1               5           


<210>  4117
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4117

Gln Tyr Thr Ser Lys Thr 
1               5       


<210>  4118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4118

Arg Ala Lys Ala Ser 
1               5   


<210>  4119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4119

Arg Ala Ser Leu Ala 
1               5   


<210>  4120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4120

Arg Glu Phe Ile Trp 
1               5   


<210>  4121
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4121

Arg Glu Phe Ile Trp Asn Asp Leu Leu 
1               5                   


<210>  4122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4122

Arg Glu Ser Asn His 
1               5   


<210>  4123
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4123

Arg Phe Tyr Thr Val 
1               5   


<210>  4124
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4124

Arg Phe Tyr Thr Val Ile Asn Lys Lys 
1               5                   


<210>  4125
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4125

Arg Gly Arg Pro 
1               


<210>  4126
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4126

Arg Lys Tyr Ala 
1               


<210>  4127
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4127

Arg Asn Arg Ser Ala 
1               5   


<210>  4128
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4128

Arg Asn Arg Ser Ala Ala 
1               5       


<210>  4129
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4129

Arg Asn Thr Ala Arg Asp 
1               5       


<210>  4130
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4130

Arg Asn Thr Ala Arg Asp Leu Leu Tyr 
1               5                   


<210>  4131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4131

Arg Pro Gly Arg Glu Ser Thr Arg Arg Trp 
1               5                   10  


<210>  4132
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4132

Arg Pro Ser Arg 
1               


<210>  4133
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4133

Arg Gln Ala Asn Glu Val Asp 
1               5           


<210>  4134
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4134

Arg Gln Gly Lys 
1               


<210>  4135
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4135

Arg Gln Gly Arg Glu 
1               5   


<210>  4136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4136

Arg Gln Asn Val Val Lys Asp Leu 
1               5               


<210>  4137
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4137

Arg Gln Tyr Thr 
1               


<210>  4138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4138

Arg Arg Thr Arg Gln 
1               5   


<210>  4139
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4139

Arg Ser Gly Glu Ala 
1               5   


<210>  4140
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4140

Arg Ser Gln Glu Tyr Lys 
1               5       


<210>  4141
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4141

Arg Ser Thr Ala Arg 
1               5   


<210>  4142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4142

Arg Thr Ala Thr Gln Arg Arg 
1               5           


<210>  4143
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4143

Arg Thr Phe Met 
1               


<210>  4144
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4144

Arg Thr Phe Met Ala Glu 
1               5       


<210>  4145
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4145

Arg Thr Ile Gln Ala Ala Lys 
1               5           


<210>  4146
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4146

Arg Thr Ser Thr Ala Ser Thr 
1               5           


<210>  4147
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4147

Arg Thr Ser Thr Ala Ser Thr 
1               5           


<210>  4148
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4148

Ser Glu Glu Asp Arg 
1               5   


<210>  4149
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4149

Ser Phe Val Ile 
1               


<210>  4150
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4150

Ser Phe Val Ile Glu 
1               5   


<210>  4151
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4151

Ser Phe Val Ile Glu Gly Leu Lys 
1               5               


<210>  4152
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4152

Ser Phe Tyr Arg 
1               


<210>  4153
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4153

Ser Gly Cys Val 
1               


<210>  4154
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4154

Ser Gly Glu Ile 
1               


<210>  4155
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4155

Ser Gly Glu Ile Val 
1               5   


<210>  4156
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4156

Ser His Cys Arg Asp 
1               5   


<210>  4157
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4157

Ser His Leu Gln 
1               


<210>  4158
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4158

Ser His Leu Gln Asn Ser 
1               5       


<210>  4159
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4159

Ser His Thr Ala 
1               


<210>  4160
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4160

Ser His Thr Ala Trp Ala Ser Ser Asp 
1               5                   


<210>  4161
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4161

Ser Ile His Val Thr Arg Glu 
1               5           


<210>  4162
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4162

Ser Lys Gln Tyr 
1               


<210>  4163
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4163

Ser Lys Thr Leu Ala Gln 
1               5       


<210>  4164
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4164

Ser Leu Gly Lys Phe Gly 
1               5       


<210>  4165
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4165

Ser Leu Lys Leu Ala 
1               5   


<210>  4166
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4166

Ser Leu Leu Lys Lys Arg Phe Ser 
1               5               


<210>  4167
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4167

Ser Asn His Pro 
1               


<210>  4168
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4168

Ser Asn His Pro Val Lys Pro 
1               5           


<210>  4169
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4169

Ser Pro Ala Arg 
1               


<210>  4170
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4170

Ser Pro Glu Arg Arg 
1               5   


<210>  4171
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4171

Ser Arg Phe Lys Asp 
1               5   


<210>  4172
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4172

Ser Arg Thr Ala Thr Gln Arg 
1               5           


<210>  4173
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4173

Ser Ser Ser Leu 
1               


<210>  4174
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4174

Ser Ser Ser Leu Ala Ser Gly Leu 
1               5               


<210>  4175
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4175

Ser Val Asn Asn 
1               


<210>  4176
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4176

Ser Val Asn Asn Asp Ile 
1               5       


<210>  4177
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4177

Ser Val Ser Ser Lys 
1               5   


<210>  4178
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4178

Ser Trp Leu Phe Leu 
1               5   


<210>  4179
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4179

Thr Ala Lys Leu Ala Tyr 
1               5       


<210>  4180
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4180

Thr Ala Lys Leu Ala Tyr Glu Gly 
1               5               


<210>  4181
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4181

Thr Cys Ser Asn 
1               


<210>  4182
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4182

Thr Cys Ser Asn Cys Gly 
1               5       


<210>  4183
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4183

Thr Cys Ser Asn Cys Gly Phe Thr 
1               5               


<210>  4184
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4184

Thr Asp Pro Glu Gly 
1               5   


<210>  4185
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4185

Thr Asp Pro Glu Gly Cys Pro 
1               5           


<210>  4186
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4186

Thr Phe Glu Arg Arg Glu 
1               5       


<210>  4187
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4187

Thr Phe Glu Arg Arg Glu Val 
1               5           


<210>  4188
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4188

Thr His Ala Ala Glu Gln Ala Ala 
1               5               


<210>  4189
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4189

Thr Ile Gln Ala 
1               


<210>  4190
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4190

Thr Leu Ala Gln Tyr Thr 
1               5       


<210>  4191
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4191

Thr Leu Pro Pro Gln 
1               5   


<210>  4192
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4192

Thr Asn Tyr Phe Gly Arg Cys Asn 
1               5               


<210>  4193
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4193

Thr Pro Thr Thr Ser Ala Asp Ala Thr Cys 
1               5                   10  


<210>  4194
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4194

Thr Arg Met Glu 
1               


<210>  4195
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4195

Thr Ser Lys Thr Cys 
1               5   


<210>  4196
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4196

Thr Thr Ile Asn Gly 
1               5   


<210>  4197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4197

Thr Thr Ile Asn Gly Lys Glu 
1               5           


<210>  4198
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4198

Val Ala Lys Pro Leu Leu Gln Gln 
1               5               


<210>  4199
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4199

Val Ala Gln Ile 
1               


<210>  4200
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4200

Val Ala Ser Phe Leu 
1               5   


<210>  4201
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4201

Val Ala Ser Phe Leu Thr 
1               5       


<210>  4202
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4202

Val Cys Leu Asn Cys 
1               5   


<210>  4203
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4203

Val Cys Asn Val Lys Lys Leu Ile 
1               5               


<210>  4204
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4204

Val Asp Trp Trp Asp 
1               5   


<210>  4205
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4205

Val Glu Gly Gln Ile Thr 
1               5       


<210>  4206
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4206

Val Glu Gln Arg 
1               


<210>  4207
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4207

Val Glu Gln Arg Arg 
1               5   


<210>  4208
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4208

Val Glu Arg Gln Ala Asn Glu 
1               5           


<210>  4209
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4209

Val Ile Glu Lys Thr Leu Tyr 
1               5           


<210>  4210
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4210

Val Ile Glu Lys Thr Leu Tyr Asn 
1               5               


<210>  4211
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4211

Val Lys Pro Leu Glu 
1               5   


<210>  4212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4212

Val Lys Pro Leu Glu Gln Ile 
1               5           


<210>  4213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4213

Val Leu Asp Ser Ser Asn Ile Lys 
1               5               


<210>  4214
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4214

Val Leu Glu Lys 
1               


<210>  4215
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4215

Val Pro Ser Lys 
1               


<210>  4216
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4216

Val Ser Cys Lys 
1               


<210>  4217
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4217

Val Ser Glu His Glu 
1               5   


<210>  4218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4218

Val Ser Glu His Glu Arg Leu 
1               5           


<210>  4219
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4219

Val Ser Glu His Glu Arg Leu Ile 
1               5               


<210>  4220
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4220

Val Ser Ile Lys 
1               


<210>  4221
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4221

Val Ser Ile Lys Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  4222
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4222

Val Ser Arg Lys 
1               


<210>  4223
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4223

Val Ser Ser Glu 
1               


<210>  4224
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4224

Val Ser Ser Glu Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  4225
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4225

Val Ser Ser Lys Ala 
1               5   


<210>  4226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4226

Val Ser Ser Lys Asp Phe Gln 
1               5           


<210>  4227
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4227

Val Ser Ser Lys Asp His 
1               5       


<210>  4228
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4228

Val Ser Ser Lys Asp Ile 
1               5       


<210>  4229
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4229

Val Ser Ser Lys Asp Leu His 
1               5           


<210>  4230
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4230

Val Ser Ser Lys Asp Leu His Ala Ser Asn 
1               5                   10  


<210>  4231
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4231

Val Ser Ser Lys Asp Leu Gln Ala Cys Leu 
1               5                   10  


<210>  4232
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4232

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Asn 
1               5                   10      


<210>  4233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4233

Val Ser Ser Lys Asp Leu Gln Ala Ser Asn Thr 
1               5                   10      


<210>  4234
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4234

Val Ser Ser Lys Asp Leu Gln Glu 
1               5               


<210>  4235
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4235

Val Ser Ser Lys Asp Leu Gln Gly 
1               5               


<210>  4236
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4236

Val Ser Ser Lys Asp Leu Val 
1               5           


<210>  4237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4237

Val Ser Ser Lys Asp Pro 
1               5       


<210>  4238
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4238

Val Ser Ser Lys Asp Val 
1               5       


<210>  4239
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4239

Val Ser Ser Lys Asp Val 
1               5       


<210>  4240
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4240

Val Ser Ser Lys Asp Val Gln 
1               5           


<210>  4241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4241

Val Ser Ser Lys Val Leu Gln 
1               5           


<210>  4242
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4242

Val Ser Ser Lys Tyr Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  4243
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4243

Val Ser Ser Asn 
1               


<210>  4244
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4244

Val Ser Ser Asn Asp 
1               5   


<210>  4245
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4245

Val Ser Ser Asn Asp Leu Gln 
1               5           


<210>  4246
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4246

Val Ser Ser Asn Asp Leu Gln Ala Ser Asn 
1               5                   10  


<210>  4247
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4247

Val Ser Ser Asn Asp Leu Gln Ala Ser Asn Lys 
1               5                   10      


<210>  4248
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4248

Val Ser Ser Arg 
1               


<210>  4249
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4249

Val Val Ala Gln 
1               


<210>  4250
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4250

Val Val Ala Gln Ile 
1               5   


<210>  4251
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4251

Val Trp Lys Pro Ala 
1               5   


<210>  4252
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4252

Val Trp Lys Pro Ala Val 
1               5       


<210>  4253
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4253

Trp Gly Lys Val Tyr Asp Glu Ala 
1               5               


<210>  4254
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4254

Trp Leu Phe Leu 
1               


<210>  4255
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4255

Trp Asn Asp Leu Leu 
1               5   


<210>  4256
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4256

Trp Pro Arg Ser 
1               


<210>  4257
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4257

Trp Thr Lys Gly Arg 
1               5   


<210>  4258
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4258

Trp Val Asn Leu Asn 
1               5   


<210>  4259
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4259

Trp Trp Asp Met Val 
1               5   


<210>  4260
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4260

Tyr Asp Glu Ala Trp Glu 
1               5       


<210>  4261
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4261

Tyr Glu Gly Leu Pro Ser 
1               5       


<210>  4262
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4262

Tyr Gly Asp Leu Arg 
1               5   


<210>  4263
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4263

Tyr Lys Lys Tyr Gln 
1               5   


<210>  4264
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4264

Tyr Leu Ile Ile Asn 
1               5   


<210>  4265
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4265

Tyr Leu Ser Lys Thr Leu Ala 
1               5           


<210>  4266
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4266

Tyr Asn Arg Arg Thr Arg 
1               5       


<210>  4267
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4267

Tyr Asn Arg Tyr Lys 
1               5   


<210>  4268
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4268

Tyr Gln Phe Gly 
1               


<210>  4269
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4269

Tyr Gln Thr Asn 
1               


<210>  4270
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4270

Tyr Thr Arg Met 
1               


<210>  4271
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4271

Tyr Thr Arg Met Glu 
1               5   


<210>  4272
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4272

Tyr Thr Arg Met Glu Asp 
1               5       


<210>  4273
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4273

Tyr Thr Ser Lys 
1               


<210>  4274
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4274

Tyr Thr Val Ile Asn Lys Lys 
1               5           


<210>  4275
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4275

Tyr Val Ser Ser Lys Asp Leu 
1               5           


<210>  4276
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4276

Tyr Val Ser Ser Lys Asp Leu Gln 
1               5               


<210>  4277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DME variant alteration

<400>  4277

Tyr Val Ser Ser Lys Asp Leu Gln Ala 
1               5                   


<210>  4278
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4278
acaugaggau uacccaugu                                                    19


<210>  4279
<211>  18
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4279
ugcaugucua agacagca                                                     18


<210>  4280
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4280
aauccauugc acuccggauu                                                   20


<210>  4281
<211>  12
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4281
ccucuucgga gg                                                           12


<210>  4282
<211>  21
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4282
aggaguuucu auggaaaccc u                                                 21


<210>  4283
<211>  30
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4283
aggugggacg accucucggu cguccuaucu                                        30


<210>  4284
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4284
ugcucgcucc guucgagca                                                    19


<210>  4285
<211>  21
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4285
ugcucgacgc guccucgagc a                                                 21


<210>  4286
<211>  22
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4286
ugcucguuug cggcuacgag ca                                                22


<210>  4287
<211>  17
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4287
agggagggag ggagagg                                                      17


<210>  4288
<211>  19
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4288
gguuaggguu aggguuagg                                                    19


<210>  4289
<211>  25
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4289
cugcucagua cgagaggaac cgcag                                             25


<210>  4290
<211>  78
<212>  RNA
<213>  Unknown

<220>
<223>  exogenous stem loop region

<400>  4290
uacacuggga ucgcugaauu agagaucggc guccuuucau ucuauauacu uuggaguuuu       60

aaaaugucuc uaaguaca                                                     78


<210>  4291
<211>  29
<212>  RNA
<213>  Unknown

<220>
<223>  extended stem region

<400>  4291
gcgcuuacgg acuucggucc guaagaagc                                         29


<210>  4292
<211>  20
<212>  RNA
<213>  Unknown

<220>
<223>  extended stem region

<400>  4292
gcucccucuu cggagggagc                                                   20


<210>  4293
<211>  27
<212>  RNA
<213>  Unknown

<220>
<223>  extended stem region

<400>  4293
gcucacauga ggaucaccca ugugagc                                           27


<210>  4294
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_002

<400>  4294
caagcagaag acggcatacg agatacatcg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4295
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_003

<400>  4295
caagcagaag acggcatacg agatgcctaa gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4296
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_004

<400>  4296
caagcagaag acggcatacg agattggtca gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4297
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_005

<400>  4297
caagcagaag acggcatacg agatcactgt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4298
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_006

<400>  4298
caagcagaag acggcatacg agatattggc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4299
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_007

<400>  4299
caagcagaag acggcatacg agatgatctg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4300
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_008

<400>  4300
caagcagaag acggcatacg agattcaagt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4301
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_009

<400>  4301
caagcagaag acggcatacg agatctgatc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4302
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_010

<400>  4302
caagcagaag acggcatacg agataagcta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4303
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_011

<400>  4303
caagcagaag acggcatacg agatgtagcc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4304
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_012

<400>  4304
caagcagaag acggcatacg agattacaag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4305
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_013

<400>  4305
caagcagaag acggcatacg agatttgact gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4306
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_014

<400>  4306
caagcagaag acggcatacg agatggaact gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4307
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_015

<400>  4307
caagcagaag acggcatacg agattgacat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4308
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_016

<400>  4308
caagcagaag acggcatacg agatggacgg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4309
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_017

<400>  4309
caagcagaag acggcatacg agatctctac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4310
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_018

<400>  4310
caagcagaag acggcatacg agatgcggac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4311
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_019

<400>  4311
caagcagaag acggcatacg agattttcac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4312
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_020

<400>  4312
caagcagaag acggcatacg agatggccac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4313
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_021

<400>  4313
caagcagaag acggcatacg agatcgaaac gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4314
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_022

<400>  4314
caagcagaag acggcatacg agatcgtacg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4315
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_023

<400>  4315
caagcagaag acggcatacg agatccactc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4316
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_024

<400>  4316
caagcagaag acggcatacg agatgctacc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4317
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_025

<400>  4317
caagcagaag acggcatacg agatatcagt gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4318
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_026

<400>  4318
caagcagaag acggcatacg agatgctcat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4319
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_027

<400>  4319
caagcagaag acggcatacg agataggaat gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4320
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_028

<400>  4320
caagcagaag acggcatacg agatcttttg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4321
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_029

<400>  4321
caagcagaag acggcatacg agattagttg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4322
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_030

<400>  4322
caagcagaag acggcatacg agatccggtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4323
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_031

<400>  4323
caagcagaag acggcatacg agatatcgtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4324
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_032

<400>  4324
caagcagaag acggcatacg agattgagtg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4325
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_033

<400>  4325
caagcagaag acggcatacg agatcgcctg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4326
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_034

<400>  4326
caagcagaag acggcatacg agatgccatg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4327
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_035

<400>  4327
caagcagaag acggcatacg agataaaatg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4328
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_036

<400>  4328
caagcagaag acggcatacg agattgttgg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4329
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_037

<400>  4329
caagcagaag acggcatacg agatattccg gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4330
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_038

<400>  4330
caagcagaag acggcatacg agatagctag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4331
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_039

<400>  4331
caagcagaag acggcatacg agatgtatag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4332
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_040

<400>  4332
caagcagaag acggcatacg agattctgag gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4333
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_041

<400>  4333
caagcagaag acggcatacg agatgtcgtc gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4334
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_042

<400>  4334
caagcagaag acggcatacg agatcgatta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4335
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_043

<400>  4335
caagcagaag acggcatacg agatgctgta gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4336
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_044

<400>  4336
caagcagaag acggcatacg agatattata gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4337
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_045

<400>  4337
caagcagaag acggcatacg agatgaatga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4338
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_046

<400>  4338
caagcagaag acggcatacg agattcggga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4339
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_047

<400>  4339
caagcagaag acggcatacg agatcttcga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4340
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v1_048

<400>  4340
caagcagaag acggcatacg agattgccga gtgactggag ttcagacgtg tgctcttccg       60

atct                                                                    64


<210>  4341
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_001

<400>  4341
caagcagaag acggcatacg agataaccgc gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4342
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_002

<400>  4342
caagcagaag acggcatacg agatggttat aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4343
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_003

<400>  4343
caagcagaag acggcatacg agatccaagt ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4344
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_004

<400>  4344
caagcagaag acggcatacg agatttggac ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4345
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_005

<400>  4345
caagcagaag acggcatacg agatcagtgg atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4346
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_006

<400>  4346
caagcagaag acggcatacg agattgacaa gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4347
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_007

<400>  4347
caagcagaag acggcatacg agatctagct tggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4348
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_008

<400>  4348
caagcagaag acggcatacg agattcgatc cagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4349
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_009

<400>  4349
caagcagaag acggcatacg agatcctgaa ctgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4350
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_010

<400>  4350
caagcagaag acggcatacg agatttcagg tcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4351
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_011

<400>  4351
caagcagaag acggcatacg agatagtaga gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4352
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_012

<400>  4352
caagcagaag acggcatacg agatgacgag aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4353
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_013

<400>  4353
caagcagaag acggcatacg agatagactt gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4354
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_014

<400>  4354
caagcagaag acggcatacg agatgagtcc aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4355
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_015

<400>  4355
caagcagaag acggcatacg agatcttaag ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4356
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_016

<400>  4356
caagcagaag acggcatacg agattccgga ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4357
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_017

<400>  4357
caagcagaag acggcatacg agatctgtat tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4358
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_018

<400>  4358
caagcagaag acggcatacg agattcacgc cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4359
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_019

<400>  4359
caagcagaag acggcatacg agatacttac atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4360
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_020

<400>  4360
caagcagaag acggcatacg agatgtccgt gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4361
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_021

<400>  4361
caagcagaag acggcatacg agataaggta ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4362
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_022

<400>  4362
caagcagaag acggcatacg agatggaacg ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4363
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_023

<400>  4363
caagcagaag acggcatacg agataattct gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4364
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_024

<400>  4364
caagcagaag acggcatacg agatggcctc atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4365
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_025

<400>  4365
caagcagaag acggcatacg agatatctta gtgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4366
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_026

<400>  4366
caagcagaag acggcatacg agatgctccg acgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4367
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_027

<400>  4367
caagcagaag acggcatacg agatatacca aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4368
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_028

<400>  4368
caagcagaag acggcatacg agatgcgttg gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4369
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_029

<400>  4369
caagcagaag acggcatacg agatcttcac gggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4370
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_030

<400>  4370
caagcagaag acggcatacg agattcctgt aagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4371
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_031

<400>  4371
caagcagaag acggcatacg agatagaatg ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4372
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_032

<400>  4372
caagcagaag acggcatacg agatgaggca ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4373
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_033

<400>  4373
caagcagaag acggcatacg agatcctcgg tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4374
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_034

<400>  4374
caagcagaag acggcatacg agatttctaa cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4375
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_035

<400>  4375
caagcagaag acggcatacg agatatgagg ctgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4376
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_036

<400>  4376
caagcagaag acggcatacg agatgcagaa tcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4377
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_037

<400>  4377
caagcagaag acggcatacg agatcactac gagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4378
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_038

<400>  4378
caagcagaag acggcatacg agattgtcgt aggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4379
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_039

<400>  4379
caagcagaag acggcatacg agataccact tagtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4380
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_040

<400>  4380
caagcagaag acggcatacg agatgttgtc cggtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4381
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_041

<400>  4381
caagcagaag acggcatacg agatatccat atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4382
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_042

<400>  4382
caagcagaag acggcatacg agatgcttgc gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4383
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_043

<400>  4383
caagcagaag acggcatacg agatagtatc ttgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4384
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_044

<400>  4384
caagcagaag acggcatacg agatgacgct ccgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4385
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_045

<400>  4385
caagcagaag acggcatacg agatcatgcc atgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4386
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_046

<400>  4386
caagcagaag acggcatacg agattgcatt gcgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4387
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_047

<400>  4387
caagcagaag acggcatacg agatattgga acgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4388
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_Rvs_v2_048

<400>  4388
caagcagaag acggcatacg agatgccaag gtgtgactgg agttcagacg tgtgctcttc       60

c                                                                       61


<210>  4389
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v1_univ

<400>  4389
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatct         58


<210>  4390
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_univ

<400>  4390
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tc               52


<210>  4391
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_001

<400>  4391
aatgatacgg cgaccaccga gatctacaca gcgctagaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4392
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_002

<400>  4392
aatgatacgg cgaccaccga gatctacacg atatcgaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4393
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_003

<400>  4393
aatgatacgg cgaccaccga gatctacacc gcagacgaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4394
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_004

<400>  4394
aatgatacgg cgaccaccga gatctacact atgagtaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4395
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_005

<400>  4395
aatgatacgg cgaccaccga gatctacaca ggtgcgtaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4396
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_006

<400>  4396
aatgatacgg cgaccaccga gatctacacg aacatacaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4397
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_007

<400>  4397
aatgatacgg cgaccaccga gatctacaca catagcgaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4398
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_008

<400>  4398
aatgatacgg cgaccaccga gatctacacg tgcgataaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4399
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_009

<400>  4399
aatgatacgg cgaccaccga gatctacacc caacagaaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4400
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_010

<400>  4400
aatgatacgg cgaccaccga gatctacact tggtgagaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4401
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_011

<400>  4401
aatgatacgg cgaccaccga gatctacacc gcggttcaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4402
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR2_fwd_v2_012

<400>  4402
aatgatacgg cgaccaccga gatctacact ataacctaca ctctttccct acacgacgct       60

cttc                                                                    64


<210>  4403
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  stem loop sequence


<220>
<221>  misc_feature
<222>  (4)..(23)
<223>  n is any ribonucleotide

<220>
<221>  misc_feature
<222>  (7)..(23)
<223>  These individual nucleotides may be absent

<400>  4403
uuunnnnnnn nnnnnnnnnn nnnuuu                                            26


<210>  4404
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4404
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgaatgct gtcagcttca       60


<210>  4405
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4405
tgaagctgac agcattcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4406
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4406
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgagtgct gtcagcttca       60


<210>  4407
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4407
tgaagctgac agcactcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4408
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4408
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgactgct gtcagcttca       60


<210>  4409
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4409
tgaagctgac agcagtcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4410
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4410
agcgcgagca cagctaaggc cacggagcga gacatctcgg cccgattgct gtcagcttca       60


<210>  4411
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM cleavage assay DNA substrate

<400>  4411
tgaagctgac agcaatcggg ccgagatgtc tcgctccgtg gccttagctg tgctcgcgct       60


<210>  4412
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4412

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Gly Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4413
<211>  986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4413

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Val Val Glu 
                325                 330                 335     


Arg Arg Glu Asn Glu Val Asp Trp Trp Asn Thr Ile Asn Glu Val Lys 
            340                 345                 350         


Lys Leu Ile Asp Ala Lys Arg Asp Met Gly Arg Val Phe Trp Ser Gly 
        355                 360                 365             


Val Thr Ala Glu Lys Arg Asn Thr Ile Leu Glu Gly Tyr Asn Tyr Leu 
    370                 375                 380                 


Pro Asn Glu Asn Asp His Lys Lys Arg Glu Gly Ser Leu Glu Asn Pro 
385                 390                 395                 400 


Lys Lys Pro Ala Lys Arg Gln Phe Gly Asp Leu Leu Leu Tyr Leu Glu 
                405                 410                 415     


Lys Lys Tyr Ala Gly Asp Trp Gly Lys Val Phe Asp Glu Ala Trp Glu 
            420                 425                 430         


Arg Ile Asp Lys Lys Ile Ala Gly Leu Thr Ser His Ile Glu Arg Glu 
        435                 440                 445             


Glu Ala Arg Asn Ala Glu Asp Ala Gln Ser Lys Ala Val Leu Thr Asp 
    450                 455                 460                 


Trp Leu Arg Ala Lys Ala Ser Phe Val Leu Glu Arg Leu Lys Glu Met 
465                 470                 475                 480 


Asp Glu Lys Glu Phe Tyr Ala Cys Glu Ile Gln Leu Gln Lys Trp Tyr 
                485                 490                 495     


Gly Asp Leu Arg Gly Asn Pro Phe Ala Val Glu Ala Glu Asn Ser Ile 
            500                 505                 510         


Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr Asn Cys Ala Phe Ile Trp 
        515                 520                 525             


Gln Lys Asp Gly Val Lys Lys Leu Asn Leu Tyr Leu Ile Ile Asn Tyr 
    530                 535                 540                 


Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys Ile Lys Pro Glu Ala Phe 
545                 550                 555                 560 


Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn Lys Lys Ser Gly Glu Ile 
                565                 570                 575     


Val Pro Met Glu Val Asn Phe Asn Phe Asp Asp Pro Asn Leu Ile Ile 
            580                 585                 590         


Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly Arg Glu Phe Ile Trp Asn 
        595                 600                 605             


Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu Lys Leu Ala Asn Gly Arg 
    610                 615                 620                 


Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg Thr Arg Gln Asp Glu Pro 
625                 630                 635                 640 


Ala Leu Phe Val Ala Leu Thr Phe Glu Arg Arg Glu Val Leu Asp Ser 
                645                 650                 655     


Ser Asn Ile Lys Pro Met Asn Leu Ile Gly Ile Asp Arg Gly Glu Asn 
            660                 665                 670         


Ile Pro Ala Val Ile Ala Leu Thr Asp Pro Glu Gly Cys Pro Leu Ser 
        675                 680                 685             


Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr His Ile Leu Arg Ile Gly 
    690                 695                 700                 


Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile Gln Ala Lys Lys Glu Val 
705                 710                 715                 720 


Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg Lys Tyr Ala Ser Lys Ala 
                725                 730                 735     


Lys Asn Leu Ala Asp Asp Met Val Arg Asn Thr Ala Arg Asp Leu Leu 
            740                 745                 750         


Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu Ile Phe Glu Asn Leu Ser 
        755                 760                 765             


Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr Phe Met Ala Glu Arg Gln 
    770                 775                 780                 


Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala Lys Leu Ala Tyr Glu Gly 
785                 790                 795                 800 


Leu Ser Lys Thr Tyr Leu Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys 
                805                 810                 815     


Thr Cys Ser Asn Cys Gly Phe Thr Ile Thr Ser Ala Asp Tyr Asp Arg 
            820                 825                 830         


Val Leu Glu Lys Leu Lys Lys Thr Ala Thr Gly Trp Met Thr Thr Ile 
        835                 840                 845             


Asn Gly Lys Glu Leu Lys Val Glu Gly Gln Ile Thr Tyr Tyr Asn Arg 
    850                 855                 860                 


Tyr Lys Arg Gln Asn Val Val Lys Asp Leu Ser Val Glu Leu Asp Arg 
865                 870                 875                 880 


Leu Ser Glu Glu Ser Val Asn Asn Asp Ile Ser Ser Trp Thr Lys Gly 
                885                 890                 895     


Arg Ser Gly Glu Ala Leu Ser Leu Leu Lys Lys Arg Phe Ser His Arg 
            900                 905                 910         


Pro Val Gln Glu Lys Phe Val Cys Leu Asn Cys Gly Phe Glu Thr His 
        915                 920                 925             


Ala Asp Glu Gln Ala Ala Leu Asn Ile Ala Arg Ser Trp Leu Phe Leu 
    930                 935                 940                 


Arg Ser Gln Glu Tyr Lys Lys Tyr Gln Thr Asn Lys Thr Thr Gly Asn 
945                 950                 955                 960 


Thr Asp Lys Arg Ala Phe Val Glu Thr Trp Gln Ser Phe Tyr Arg Lys 
                965                 970                 975     


Lys Leu Lys Glu Val Trp Lys Pro Ala Val 
            980                 985     


<210>  4414
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4414

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Val Asn Leu Ile 
                645                 650                 655     


Gly Val Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Pro Glu Phe Lys Asp Ser Ser Gly Gly Pro 
        675                 680                 685             


Thr Asp Ile Leu Arg Ile Gly Glu Gly Tyr Lys Glu Lys Gln Arg Ala 
    690                 695                 700                 


Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Phe Ala Ser Lys Ser Arg Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Ser Ala Arg Asp Leu Phe Tyr His Ala Val Thr His Asp Ala Val 
            740                 745                 750         


Leu Val Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Thr Glu Arg Gln Tyr Thr Lys Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Thr Ser Lys Thr Tyr Leu Ser Lys 
785                 790                 795                 800 


Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr 
                805                 810                 815     


Ile Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr 
            820                 825                 830         


Ala Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu 
        835                 840                 845             


Gly Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys 
    850                 855                 860                 


Asp Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn 
865                 870                 875                 880 


Asp Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu 
                885                 890                 895     


Leu Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys 
            900                 905                 910         


Leu Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn 
        915                 920                 925             


Ile Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr 
    930                 935                 940                 


Gln Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu 
945                 950                 955                 960 


Thr Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro 
                965                 970                 975     


Ala Val 
        


<210>  4415
<211>  972
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CasX variant

<400>  4415

Met Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys 
1               5                   10                  15      


Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu 
            20                  25                  30          


Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu 
        35                  40                  45              


Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg 
    50                  55                  60                  


Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala 
65                  70                  75                  80  


Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu 
                85                  90                  95      


Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys 
            100                 105                 110         


Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe 
        115                 120                 125             


Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln 
    130                 135                 140                 


Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn 
145                 150                 155                 160 


Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu 
                165                 170                 175     


Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg 
            180                 185                 190         


Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro 
        195                 200                 205             


Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro 
    210                 215                 220                 


Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe 
225                 230                 235                 240 


Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys 
                245                 250                 255     


Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn 
            260                 265                 270         


Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys 
        275                 280                 285             


Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp 
    290                 295                 300                 


Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala 
305                 310                 315                 320 


Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu 
                325                 330                 335     


Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys 
            340                 345                 350         


Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn 
        355                 360                 365             


Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Arg Pro Tyr Leu Ser Ser 
    370                 375                 380                 


Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly 
385                 390                 395                 400 


Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys 
                405                 410                 415     


Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu 
            420                 425                 430         


Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln 
        435                 440                 445             


Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val 
    450                 455                 460                 


Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu 
465                 470                 475                 480 


Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala 
                485                 490                 495     


Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln 
            500                 505                 510         


Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn 
        515                 520                 525             


Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys 
    530                 535                 540                 


Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile 
545                 550                 555                 560 


Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe 
                565                 570                 575     


Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln 
            580                 585                 590         


Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser 
        595                 600                 605             


Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg 
    610                 615                 620                 


Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu 
625                 630                 635                 640 


Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile 
                645                 650                 655     


Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp 
            660                 665                 670         


Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro 
        675                 680                 685             


Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr 
    690                 695                 700                 


Ile Gln Ala Lys Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser 
705                 710                 715                 720 


Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg 
                725                 730                 735     


Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met 
            740                 745                 750         


Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg 
        755                 760                 765             


Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr 
    770                 775                 780                 


Ala Lys Leu Ala Tyr Glu Gly Leu Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Asn Ser Asn Ser Thr Glu Phe Lys Ser 
    930                 935                 940                 


Tyr Lys Ser Gly Lys Gln Pro Phe Val Gly Ala Trp Gln Ala Phe Tyr 
945                 950                 955                 960 


Lys Arg Arg Leu Lys Glu Val Trp Lys Pro Asn Ala 
                965                 970         

