                         SEQUENCE LISTING

<110>  ARROWHEAD PHARMACEUTICALS, INC.
               
<120>  Methods For The Treatment of Alpha-1 Antitrypsin Deficiency (AATD)

<130>  30674-WO1

<160>  6

<210>  1
<211>  3220
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Homo sapiens serpin family A member 1 (SERPINA1),
gene transcript variant 1 (NM_000295.4)

<400> 1

acaatgactc ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg     60

gcagcgtagg cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg     120

ataactgggg tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc     180

cactgcttaa atacggacga ggacagggcc ctgtctcctc agcttcaggc accaccactg     240

acctgggaca gtgaatcgac aatgccgtct tctgtctcgt ggggcatcct cctgctggca     300

ggcctgtgct gcctggtccc tgtctccctg gctgaggatc cccagggaga tgctgcccag     360

aagacagata catcccacca tgatcaggat cacccaacct tcaacaagat cacccccaac     420

ctggctgagt tcgccttcag cctataccgc cagctggcac accagtccaa cagcaccaat     480

atcttcttct ccccagtgag catcgctaca gcctttgcaa tgctctccct ggggaccaag     540

gctgacactc acgatgaaat cctggagggc ctgaatttca acctcacgga gattccggag     600

gctcagatcc atgaaggctt ccaggaactc ctccgtaccc tcaaccagcc agacagccag     660

ctccagctga ccaccggcaa tggcctgttc ctcagcgagg gcctgaagct agtggataag     720

tttttggagg atgttaaaaa gttgtaccac tcagaagcct tcactgtcaa cttcggggac     780

accgaagagg ccaagaaaca gatcaacgat tacgtggaga agggtactca agggaaaatt     840

gtggatttgg tcaaggagct tgacagagac acagtttttg ctctggtgaa ttacatcttc     900

tttaaaggca aatgggagag accctttgaa gtcaaggaca ccgaggaaga ggacttccac     960

gtggaccagg tgaccaccgt gaaggtgcct atgatgaagc gtttaggcat gtttaacatc     1020

cagcactgta agaagctgtc cagctgggtg ctgctgatga aatacctggg caatgccacc     1080

gccatcttct tcctgcctga tgaggggaaa ctacagcacc tggaaaatga actcacccac     1140

gatatcatca ccaagttcct ggaaaatgaa gacagaaggt ctgccagctt acatttaccc     1200

aaactgtcca ttactggaac ctatgatctg aagagcgtcc tgggtcaact gggcatcact     1260

aaggtcttca gcaatggggc tgacctctcc ggggtcacag aggaggcacc cctgaagctc     1320

tccaaggccg tgcataaggc tgtgctgacc atcgacgaga aagggactga agctgctggg     1380

gccatgtttt tagaggccat acccatgtct atcccccccg aggtcaagtt caacaaaccc     1440

tttgtcttct taatgattga acaaaatacc aagtctcccc tcttcatggg aaaagtggtg     1500

aatcccaccc aaaaataact gcctctcgct cctcaacccc tcccctccat ccctggcccc     1560

ctccctggat gacattaaag aagggttgag ctggtccctg cctgcatgtg actgtaaatc     1620

cctcccatgt tttctctgag tctccctttg cctgctgagg ctgtatgtgg gctccaggta     1680

acagtgctgt cttcgggccc cctgaactgt gttcatggag catctggctg ggtaggcaca     1740

tgctgggctt gaatccaggg gggactgaat cctcagctta cggacctggg cccatctgtt     1800

tctggagggc tccagtcttc cttgtcctgt cttggagtcc ccaagaagga atcacagggg     1860

aggaaccaga taccagccat gaccccaggc tccaccaagc atcttcatgt ccccctgctc     1920

atcccccact cccccccacc cagagttgct catcctgcca gggctggctg tgcccacccc     1980

aaggctgccc tcctgggggc cccagaactg cctgatcgtg ccgtggccca gttttgtggc     2040

atctgcagca acacaagaga gaggacaatg tcctcctctt gacccgctgt cacctaacca     2100

gactcgggcc ctgcacctct caggcacttc tggaaaatga ctgaggcaga ttcttcctga     2160

agcccattct ccatggggca acaaggacac ctattctgtc cttgtccttc catcgctgcc     2220

ccagaaagcc tcacatatct ccgtttagaa tcaggtccct tctccccaga tgaagaggag     2280

ggtctctgct ttgttttctc tatctcctcc tcagacttga ccaggcccag caggccccag     2340

aagaccatta ccctatatcc cttctcctcc ctagtcacat ggccataggc ctgctgatgg     2400
 
ctcaggaagg ccattgcaag gactcctcag ctatgggaga ggaagcacat cacccattga     2460

cccccgcaac ccctcccttt cctcctctga gtcccgactg gggccacatg cagcctgact     2520

tctttgtgcc tgttgctgtc cctgcagtct tcagagggcc accgcagctc cagtgccacg     2580

gcaggaggct gttcctgaat agcccctgtg gtaagggcca ggagagtcct tccatcctcc     2640

aaggccctgc taaaggacac agcagccagg aagtcccctg ggcccctagc tgaaggacag     2700

cctgctccct ccgtctctac caggaatggc cttgtcctat ggaaggcact gccccatccc     2760

aaactaatct aggaatcact gtctaaccac tcactgtcat gaatgtgtac ttaaaggatg     2820

aggttgagtc ataccaaata gtgatttcga tagttcaaaa tggtgaaatt agcaattcta     2880

catgattcag tctaatcaat ggataccgac tgtttcccac acaagtctcc tgttctctta     2940

agcttactca ctgacagcct ttcactctcc acaaatacat taaagatatg gccatcacca     3000

agccccctag gatgacacca gacctgagag tctgaagacc tggatccaag ttctgacttt     3060

tccccctgac agctgtgtga ccttcgtgaa gtcgccaaac ctctctgagc cccagtcatt     3120

gctagtaaga cctgcctttg agttggtatg atgttcaagt tagataacaa aatgtttata     3180

cccattagaa cagagaataa atagaactac atttcttgca                           3220


<210>  2
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AAT RNAi agent antisense strand modified sequence

<400>  2
uguuaaacau gccuaaacgc u                                         21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AAT RNAi agent antisense strand underlying base sequence

<400>  3
uguuaaacau gccuaaacgc u                                         21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AAT RNAi agent sense strand modified sequence

<400>  4
agcguuuagg cauguuuaac a                                         21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AAT RNAi agent sense strand underlying base sequence

<400>  5
agaugcugcc cagaagacac a                                         21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  AAT RNAi agent sense strand modified sequence

<400>  6
agcguuuagg cauguuuaac a                                         21