                         SEQUENCE LISTING

<110>  The Children's Hopsital Medical Center
 
<120>  Methods and Compositions for Treatment of Neurodegeneration

<130>  0732574

<150>  62/857,972
<151>  2019-06-06

<150>  62/983,856
<151>  2020-03-02

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 1

<400>  1

Phe Lys Arg Ser Leu Leu Arg 
1               5           


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 2

<400>  2

Phe Lys Arg Leu Leu Leu Arg 
1               5           


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 3

<400>  3

Phe Lys Arg Ser Cys 
1               5   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 4

<400>  4

Phe Lys Arg Ser Leu Leu Cys 
1               5           


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 5

<400>  5

Phe Lys Arg Leu Leu Leu Tyr 
1               5           


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 6

<400>  6

Phe Lys Lys Ala Leu Leu Arg 
1               5           


<210>  7
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 7

<400>  7

Phe Lys Arg Ser 
1               


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5aR Seq 8

<400>  8

Phe Lys Leu Leu Leu Leu Arg 
1               5           


<210>  9
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a-(1-66,Cys27Ala)-A8B

<400>  9

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Ser Leu Leu Arg 
65                  70              


<210>  10
<211>  73
<212>  PRT
<213>  Homo sapiens (C5A-(1-66,Cys27Ala)-A8B-Leu70

<400>  10

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Leu Leu Leu Arg 
65                  70              


<210>  11
<211>  71
<212>  PRT
<213>  Homo sapiens (C5a(1-66,Cys27Ala)-A8B-Cys71)

<400>  11

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Ser Cys 
65                  70      


<210>  12
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a-(1-66,Cys27Ala)-A8B-Cys73)

<400>  12

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Ser Leu Leu Cys 
65                  70              


<210>  13
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a(1-66, Cys27Ala)-A8B-Leu70-Tyr73)

<400>  13

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Leu Leu Leu Tyr 
65                  70              


<210>  14
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a-(1-66, Cys27Ala)-A8B-Lys69-Ala70)

<400>  14

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Lys Ala Leu Leu Arg 
65                  70              


<210>  15
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a(1-66,Cys27Arg)-A8b)

<400>  15

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Arg Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Ser Leu Leu Arg 
65                  70              


<210>  16
<211>  70
<212>  PRT
<213>  Homo sapiens (C5a-(1-66,Cys27Ala)-A8B-Del 71-73

<400>  16

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Ala Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Arg Ser 
65                  70  


<210>  17
<211>  76
<212>  PRT
<213>  Homo sapiens (C5a-(1-66,Cys-3,Gly-2,-1,Cys27Ala)-A8B)

<400>  17

Cys Gly Gly Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr 
1               5                   10                  15      


Lys His Ser Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Arg Val Asn 
            20                  25                  30          


Asn Asp Glu Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro 
        35                  40                  45              


Arg Cys Ile Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu 
    50                  55                  60                  


Arg Ala Asn Ile Ser Phe Lys Arg Ser Leu Leu Arg 
65                  70                  75      


<210>  18
<211>  73
<212>  PRT
<213>  Homo sapiens (C5a-(1-66,Cys27Ala)A5a)

<400>  18

Thr Leu Gln Lys Lys Ile Glu Glu Ile Ala Ala Lys Tyr Lys His Ser 
1               5                   10                  15      


Val Val Lys Lys Cys Cys Tyr Asp Gly Ala Arg Val Asn Asn Asp Glu 
            20                  25                  30          


Thr Cys Glu Gln Arg Ala Ala Arg Ile Ser Leu Gly Pro Arg Cys Ile 
        35                  40                  45              


Lys Ala Phe Thr Glu Cys Cys Val Val Ala Ser Gln Leu Arg Ala Asn 
    50                  55                  60                  


Ile Ser Phe Lys Leu Leu Leu Leu Arg 
65                  70              


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  19

Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10      


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P32

<400>  20

Arg His Tyr Pro Tyr Trp Arg 
1               5           


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P59

<400>  21

Leu Ile Arg Leu Trp Arg 
1               5       


