                         SEQUENCE LISTING

<110>  Massachusetts General Hospital
 
<120>  ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS THAT TARGET TACI

<130>  M1053.70007WO00

<140>  PCT/US2020/036108
<141>  2020-06-04

<150>  US 63/012,735
<151>  2020-04-20

<150>  US 62/907,930
<151>  2019-09-30

<150>  US 62/856,998
<151>  2019-06-04

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Ser 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  4
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Ser 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala 
            180                 185                 190         


Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr 
    210                 215                 220                 


Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Lys 
                245             


<210>  5
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Ser Val Thr Val Ser Ser 
                245             


<210>  6
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  7
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  8
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  10
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Ser 
            20                  25                  30          


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp 
                165                 170                 175     


Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala 
            180                 185                 190         


Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        195                 200                 205             


Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr 
    210                 215                 220                 


Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  11
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
            20                  25                  30          


Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His 
65                  70                  75                  80  


Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
    130                 135                 140                 


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
145                 150                 155                 160 


Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
                165                 170                 175     


Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn 
            180                 185                 190         


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
        195                 200                 205             


Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
                245                 250                 255     


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
            260                 265                 270         


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
        275                 280                 285             


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
    290                 295                 300                 


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
305                 310                 315                 320 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
                325                 330                 335     


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
            340                 345                 350         


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
        355                 360                 365             


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
    370                 375                 380                 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
385                 390                 395                 400 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
                405                 410                 415     


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
            420                 425                 430         


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
        435                 440                 445             


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
    450                 455                 460                 


Met Gln Ala Leu Pro Pro Arg 
465                 470     


<210>  12
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro 
65                  70                  75                  80  


Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met 
            180                 185                 190         


Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu 
225                 230                 235                 240 


Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala 
                245                 250                 255     


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  13
<211>  492
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe 
            100                 105                 110         


Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly 
145                 150                 155                 160 


Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr 
                165                 170                 175     


Ser Gly Tyr Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser 
            180                 185                 190         


His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly 
        195                 200                 205             


Gly Ser Pro Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val 
    210                 215                 220                 


Asp Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser 
225                 230                 235                 240 


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met 
                245                 250                 255     


Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  17
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210>  18
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro 
65                  70                  75                  80  


Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met 
            180                 185                 190         


Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu 
225                 230                 235                 240 


Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala 
                245                 250                 255     


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu 
    290                 295                 300                 


Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile 
305                 310                 315                 320 


Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
                325                 330                 335     


Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro 
            340                 345                 350         


Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
        355                 360                 365             


Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
    370                 375                 380                 


Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
385                 390                 395                 400 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                405                 410                 415     


Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro 
            420                 425                 430         


Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        435                 440                 445             


Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys 
    450                 455                 460                 


Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr 
465                 470                 475                 480 


Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr 
                485                 490                 495     


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr 
            500                 505                 510         


Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    610                 615                 620                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
625                 630                 635                 640 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                645                 650                 655     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg 
    770                 775 


<210>  19
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
305                 310                 315                 320 


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Ser 
                325                 330                 335     


Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
            340                 345                 350         


Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln Lys Phe 
        355                 360                 365             


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
    370                 375                 380                 


Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
385                 390                 395                 400 


Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln Gly Thr Ser 
                405                 410                 415     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser 
        435                 440                 445             


Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys 
    450                 455                 460                 


Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp 
465                 470                 475                 480 


Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala 
                485                 490                 495     


Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
            500                 505                 510         


Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr 
        515                 520                 525             


Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly 
    530                 535                 540                 


Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    610                 615                 620                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
625                 630                 635                 640 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                645                 650                 655     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg 
    770                 775 


<210>  20
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe 
            100                 105                 110         


Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly 
145                 150                 155                 160 


Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr 
                165                 170                 175     


Ser Gly Tyr Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser 
            180                 185                 190         


His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly 
        195                 200                 205             


Gly Ser Pro Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val 
    210                 215                 220                 


Asp Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser 
225                 230                 235                 240 


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met 
                245                 250                 255     


Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu 
    290                 295                 300                 


Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile 
305                 310                 315                 320 


Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
                325                 330                 335     


Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro 
            340                 345                 350         


Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
        355                 360                 365             


Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
    370                 375                 380                 


Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
385                 390                 395                 400 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                405                 410                 415     


Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro 
            420                 425                 430         


Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        435                 440                 445             


Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys 
    450                 455                 460                 


Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr 
465                 470                 475                 480 


Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr 
                485                 490                 495     


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr 
            500                 505                 510         


Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    610                 615                 620                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
625                 630                 635                 640 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                645                 650                 655     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg 
    770                 775 


<210>  21
<211>  775
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
305                 310                 315                 320 


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr 
                325                 330                 335     


Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
            340                 345                 350         


Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
        355                 360                 365             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His 
    370                 375                 380                 


Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys 
385                 390                 395                 400 


Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
        435                 440                 445             


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe 
    450                 455                 460                 


Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
465                 470                 475                 480 


Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn 
                485                 490                 495     


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
            500                 505                 510         


Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val 
        515                 520                 525             


Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln 
    530                 535                 540                 


Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro 
545                 550                 555                 560 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                565                 570                 575     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            580                 585                 590         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        595                 600                 605             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    610                 615                 620                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
625                 630                 635                 640 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                645                 650                 655     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            660                 665                 670         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        675                 680                 685             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    690                 695                 700                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                725                 730                 735     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            740                 745                 750         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        755                 760                 765             


Met Gln Ala Leu Pro Pro Arg 
    770                 775 


<210>  22
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        35                  40                  45              


Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys 
    50                  55                  60                  


Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro 
65                  70                  75                  80  


Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                85                  90                  95      


Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp 
        115                 120                 125             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg 
                165                 170                 175     


Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met 
            180                 185                 190         


Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        195                 200                 205             


Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe 
    210                 215                 220                 


Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu 
225                 230                 235                 240 


Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala 
                245                 250                 255     


Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu 
    290                 295                 300                 


Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile 
305                 310                 315                 320 


Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
                325                 330                 335     


Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro 
            340                 345                 350         


Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
        355                 360                 365             


Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
    370                 375                 380                 


Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
385                 390                 395                 400 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                405                 410                 415     


Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro 
            420                 425                 430         


Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        435                 440                 445             


Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys 
    450                 455                 460                 


Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr 
465                 470                 475                 480 


Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr 
                485                 490                 495     


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr 
            500                 505                 510         


Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  23
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
    290                 295                 300                 


Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr 
305                 310                 315                 320 


Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
                325                 330                 335     


Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln 
            340                 345                 350         


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
        355                 360                 365             


Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr 
    370                 375                 380                 


Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp Gly Gln Gly 
385                 390                 395                 400 


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                405                 410                 415     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
            420                 425                 430         


Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile 
        435                 440                 445             


Ser Cys Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu Met 
    450                 455                 460                 


Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr 
465                 470                 475                 480 


Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
                485                 490                 495     


Gly Ser Gly Thr Asp Phe Arg Leu Asn Ile His Pro Leu Glu Glu Asp 
            500                 505                 510         


Asp Thr Gly Met Tyr Phe Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr 
        515                 520                 525             


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  24
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
            20                  25                  30          


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly 
65                  70                  75                  80  


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Arg Leu Asn Ile His Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe 
            100                 105                 110         


Cys Gln Gln Ser Lys Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly 
145                 150                 155                 160 


Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr 
                165                 170                 175     


Ser Gly Tyr Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser 
            180                 185                 190         


His Gly Lys Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly 
        195                 200                 205             


Gly Ser Pro Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val 
    210                 215                 220                 


Asp Lys Ser Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser 
225                 230                 235                 240 


Glu Asp Ser Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met 
                245                 250                 255     


Asp Phe Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly 
            260                 265                 270         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Met Ser Leu 
    290                 295                 300                 


Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Thr Ile 
305                 310                 315                 320 


Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro 
                325                 330                 335     


Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln Thr Gly Val Pro 
            340                 345                 350         


Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile 
        355                 360                 365             


Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr Cys Leu Gln Ser 
    370                 375                 380                 


Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
385                 390                 395                 400 


Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
                405                 410                 415     


Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro 
            420                 425                 430         


Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
        435                 440                 445             


Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly Lys Gly Leu Lys 
    450                 455                 460                 


Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Tyr 
465                 470                 475                 480 


Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr 
                485                 490                 495     


Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp Thr Ala Thr Tyr 
            500                 505                 510         


Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
        515                 520                 525             


Thr Ser Val Thr Val Ser Ser Ala Ala Ala Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  25
<211>  761
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu 
            20                  25                  30          


Ala Met Ser Leu Gly Lys Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
        35                  40                  45              


Ser Val Thr Ile Leu Gly Ser His Leu Ile His Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Gln Pro Pro Thr Leu Leu Ile Gln Leu Ala Ser Asn Val Gln 
65                  70                  75                  80  


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Asp Pro Val Glu Glu Asp Asp Val Ala Val Tyr Tyr 
            100                 105                 110         


Cys Leu Gln Ser Arg Thr Ile Pro Arg Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly 
    130                 135                 140                 


Glu Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu 
145                 150                 155                 160 


Leu Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly 
                165                 170                 175     


Tyr Thr Phe Thr Asp Tyr Ser Ile Asn Trp Val Lys Arg Ala Pro Gly 
            180                 185                 190         


Lys Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro 
        195                 200                 205             


Ala Tyr Ala Tyr Asp Phe Arg Gly Arg Phe Ala Phe Ser Leu Glu Thr 
    210                 215                 220                 


Ser Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Tyr Glu Asp 
225                 230                 235                 240 


Thr Ala Thr Tyr Phe Cys Ala Leu Asp Tyr Ser Tyr Ala Met Asp Tyr 
                245                 250                 255     


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ala Ala Gly Gly 
            260                 265                 270         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser 
    290                 295                 300                 


Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp 
305                 310                 315                 320 


Tyr Tyr Gly Met Ser Leu Met Asn Trp Phe Gln Gln Lys Pro Gly Gln 
                325                 330                 335     


Pro Pro Lys Leu Val Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val 
            340                 345                 350         


Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Arg Leu Asn 
        355                 360                 365             


Ile His Pro Leu Glu Glu Asp Asp Thr Gly Met Tyr Phe Cys Gln Gln 
    370                 375                 380                 


Ser Lys Glu Ala Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
385                 390                 395                 400 


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            420                 425                 430         


Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr 
        435                 440                 445             


Thr Phe Thr Glu Ser Thr Ile His Trp Val Lys Gln Ser His Gly Lys 
    450                 455                 460                 


Ser Leu Glu Trp Ile Gly Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro 
465                 470                 475                 480 


Phe Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser 
                485                 490                 495     


Ser Ser Thr Val Tyr Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser 
            500                 505                 510         


Ala Val Tyr Tyr Cys Ala Lys Trp Val Arg Gly Ala Met Asp Phe Trp 
        515                 520                 525             


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
    530                 535                 540                 


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
545                 550                 555                 560 


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
                565                 570                 575     


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
            580                 585                 590         


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
        595                 600                 605             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    610                 615                 620                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
625                 630                 635                 640 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                645                 650                 655     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            660                 665                 670         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        675                 680                 685             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    690                 695                 700                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
705                 710                 715                 720 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                725                 730                 735     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            740                 745                 750         


Leu His Met Gln Ala Leu Pro Pro Arg 
        755                 760     


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Gly Tyr Thr Phe Thr Glu Ser Thr 
1               5               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Ile Ser Pro Asn Asn Gly Gly Ser 
1               5               


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Ala Lys Trp Val Arg Gly Ala Met Asp Phe 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29

Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu 
1               5                   10  


<210>  30
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30

Ala Ala Ser 
1           


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Gln Gln Ser Lys Glu Ala Pro Pro Thr 
1               5                   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Glu Ser Thr Ile His 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Gly Ile Ser Pro Asn Asn Gly Gly Ser Pro Phe Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Trp Val Arg Gly Ala Met Asp Phe 
1               5               


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Arg Ala Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu Met Asn 
1               5                   10                  15  


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Gly Tyr Thr Phe Thr Glu Ser 
1               5           


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Asn Asn Gly 
1           


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Val Arg Gly Ala Met Asp 
1               5       


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Ser Glu Ser Val Asp Tyr Tyr Gly Met Ser Leu 
1               5                   10      


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Ser Lys Glu Ala Pro Pro 
1               5       


