                         SEQUENCE LISTING

<110>  MERCK SHARP & DOHME CORP.
       Feng, Danqing
       Lin, Songnian
       Pissarnitski, Dmitri A
       Pipik, Brenda
       Yan, Lin
       Zhu, Yuping
 
<120>  GLUCOSE-RESPONSIVE INSULIN CONJUGATES

<130>  24725-WO-PCT

<150>  62/931504
<151>  2020-01-15

<150>  62/838080
<151>  2019-06-06

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  2
<211>  30
<212>  PRT
<213>  homo sapiens

<400>  2

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  3
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic A-chain Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is G or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is V, G, or K

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Q or K

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is T, H, or K

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is S or K

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is I or K

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is L or K

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Y or K

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Q or K

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is N or K

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is N, G, or K

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is R, K, or absent

<400>  3

Xaa Ile Xaa Glu Xaa Cys Cys Xaa Xaa Xaa Cys Ser Xaa Xaa Xaa Leu 
1               5                   10                  15      


Glu Xaa Tyr Cys Xaa Xaa 
            20          


<210>  4
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Generic B-chain polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is F or K

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is N or K

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Q or K

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Y or K

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is L or K

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is F or K

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is P or K

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa is K, P, R, or absent

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa is T or absent

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa is R if X30 is T, or absent

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa is P if X31 is R, or absent

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa is R if X32 is P, or absent

<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa is P if X33 is R, or absent

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is R if X34 is P, or absent

<400>  4

Xaa Val Xaa Xaa His Leu Cys Gly Ser His Leu Val Glu Ala Leu Xaa 
1               5                   10                  15      


Xaa Val Cys Gly Glu Arg Gly Phe Xaa Tyr Thr Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa 
        35  


