                         SEQUENCE LISTING

<110>  Biorchestra, Ltd.
 
<120>  USE OF MIR-204 INHIBITOR TO INCREASE NURR1 PROTEIN EXPRESSION

<130>  4366.0010000

<150>  US 62/857,202
<151>  2019-06-04

<160>  65    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p (RNA)

<400>  1
uucccuuugu cauccuaugc cu                                                22


<210>  2
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p (RNA) complement

<400>  2
aggcauagga ugacaaaggg aa                                                22


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p (DNA)

<400>  3
ttccctttgt catcctatgc ct                                                22


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p (DNA) complement

<400>  4
aggcatagga tgacaaaggg aa                                                22


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-3p (RNA)

<400>  5
gcugggaagg caaagggacg u                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-3p (RNA) complement

<400>  6
acgucccuuu gccuucccag c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR204-3p (DNA)

<400>  7
gctgggaagg caaagggacg t                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR204-3p (DNA) complement

<400>  8
acgtcccttt gccttcccag c                                                 21


<210>  9
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem 2 (RNA)

<400>  9
guauucug                                                                 8


<210>  10
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stem 2 (DNA)

<400>  10
gtattctg                                                                 8


<210>  11
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem 2 complement (RNA)

<400>  11
cagaauac                                                                 8


<210>  12
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stem 2 complement (DNA)

<400>  12
cagaatac                                                                 8


<210>  13
<211>  4
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Loop (RNA)

<400>  13
guca                                                                     4


<210>  14
<211>  4
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Loop (DNA)

<400>  14
gtca                                                                     4


<210>  15
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Stem 1 (RNA)

<400>  15
gacggcgcua ggaucauc                                                     18


<210>  16
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stem 1  (DNA)

<400>  16
gacggcgcta ggatcatc                                                     18


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stem 1 complement (RNA)

<400>  17
gaugauccua gctccguc                                                     18


<210>  18
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Stem 1 complement (DNA)

<400>  18
gatgatccta gctccgtc                                                     18


<210>  19
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Spacer (DNA/RNA)

<400>  19
aac                                                                      3


<210>  20
<211>  3
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' Spacer (DNA/RNA)

<400>  20
caa                                                                      3


<210>  21
<211>  8
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Linker (RNA)

<400>  21
aacaauac                                                                 8


<210>  22
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker (DNA)

<400>  22
aacaatac                                                                 8


<210>  23
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p TD construct

<400>  23
aaggatccga cggcgctagg atcatcaaca ggcataggat gacaaaggga acaagtattc       60

tggtcacaga atacaacagg cataggatga caaagggaac aagatgatcc tagcgccgtc      120

ttttttggaa aagcttaa                                                    138


<210>  24
<211>  136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR416 Control construct

<400>  24
aaggatccga cggcgctagg atcatcaacg gttcgtacgt acactgttca caagtattct       60

ggtcacagaa tacaacggtt cgtacgtaca ctgttcacaa gatgatccta gcgccgtctt      120

ttttggaaaa gcttaa                                                      136


<210>  25
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-5p seed sequence

<400>  25
uucccuu                                                                  7


<210>  26
<211>  7
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  miR204-3p seed sequence

<400>  26
gcuggga                                                                  7


<210>  27
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype1

<400>  27
aactcgaggt tcgatacagg ggcatcaaga ggcataggat gacaaaggga agaatttgga       60

acgtcagttc caaaaagaag aatagaaggc ataggatgac aaagggaaga agatgcccct      120

gtatcgaact tttttggaac tcgagaa                                          147


<210>  28
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype2

<400>  28
aactcgagtg cgcgctttgt ggatgtaaga ggcataggat gacaaaggga agaaacccca       60

gtgtcaactg gggtaagaag aatagaaggc ataggatgac aaagggaaga aacatccaca      120

aagcgcgcat tttttggaac tcgagaa                                          147


<210>  29
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype3

<400>  29
aactcgagaa taactagaca caatcgaaga ggcataggat gacaaaggga agaaaccttc       60

tggtcacaga aggtaagaag aatagaaggc ataggatgac aaagggaaga acgattgtgt      120

ctagttattt tttttggaac tcgagaa                                          147


<210>  30
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype4

<400>  30
aactcgaggt ttttatatgc caacacaaga ggcataggat gacaaaggga agaatacccg       60

aagtcattcg ggtaaagaag aatagaaggc ataggatgac aaagggaaga agtgttggca      120

tataaaaact tttttggaac tcgagaa                                          147


<210>  31
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype5

<400>  31
aaggatcccc ttgggcttgt agcctaaaga ggcataggat gacaaaggga agaagttgag       60

cggtcacgct caacaagaag aatagaaggc ataggatgac aaagggaaga ataggctaca      120

agcccaaggt tttttggaac tcgagaa                                          147


<210>  32
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype6

<400>  32
aaggatcctg tggattttcc aaaaggaaga ggcataggat gacaaaggga agaaaagatc       60

gtgtcaacga tcttaagaag aatagaaggc ataggatgac aaagggaaga accttttgga      120

aaatccacat tttttggaac tcgagaa                                          147


<210>  33
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype7

<400>  33
aaggatccaa gtcagcctta ttggacaaga ggcataggat gacaaaggga agaaagcaat       60

aggtcactat tgctaagaag aatagaaggc ataggatgac aaagggaaga agtccaataa      120

ggctgacttt tttttggaac tcgagaa                                          147


<210>  34
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype8

<400>  34
aaggatccta cgaccgagtt cgtagtaaga ggcataggat gacaaaggga agaacagtga       60

aagtcatttc actgaagaag aatagaaggc ataggatgac aaagggaaga aactacgaac      120

tcggtcgtat tttttggaac tcgagaa                                          147


<210>  35
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype9

<400>  35
aaggatcccc cggcgaaata ctgcgaaaga ggcataggat gacaaaggga agaatagcat       60

tcgtcagaat gctaaagaag aatagaaggc ataggatgac aaagggaaga atcgcagtat      120

ttcgccgggt tttttggaac tcgagaa                                          147


<210>  36
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype10

<400>  36
aaggatcctg gtggggacac tgagctaaga ggcataggat gacaaaggga agaagtctcg       60

cagtcatgcg agacaagaag aatagaaggc ataggatgac aaagggaaga aagctcagtg      120

tccccaccat tttttggaac tcgagaa                                          147


<210>  37
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype11

<400>  37
aaggatccta aacagatcaa cacgctaaga ggcataggat gacaaaggga agaaagttgg       60

gcgtcagccc aactaagaag aatagaaggc ataggatgac aaagggaaga aagcgtgttg      120

atctgtttat tttttggaac tcgagaa                                          147


<210>  38
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype12

<400>  38
aaggatcccg tcctacttaa gagagtaaga ggcataggat gacaaaggga agaagtctat       60

acgtcagtat agacaagaag aatagaaggc ataggatgac aaagggaaga aactctctta      120

agtaggacgt tttttggaac tcgagaa                                          147


<210>  39
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype13

<400>  39
aaggatcctg tgttccgcgg agatcaaaga ggcataggat gacaaaggga agaaacaaaa       60

acgtcagttt ttgtaagaag aatagaaggc ataggatgac aaagggaaga atgatctccg      120

cggaacacat tttttggaac tcgagaa                                          147


<210>  40
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype14

<400>  40
aaggatcctc ctgatgtaag cttacaaaga ggcataggat gacaaaggga agaaaattat       60

tcgtcagaat aattaagaag aatagaaggc ataggatgac aaagggaaga atgtaagctt      120

acatcaggat tttttggaac tcgagaa                                          147


<210>  41
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype15

<400>  41
aaggatccct ttaagtggga cgatggaaga ggcataggat gacaaaggga agaagaacgg       60

ctgtcaagcc gttcaagaag aatagaaggc ataggatgac aaagggaaga accatcgtcc      120

cacttaaagt tttttggaac tcgagaa                                          147


<210>  42
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype16

<400>  42
aaggatccac tcttagtgtc cttatgaaga ggcataggat gacaaaggga agaaagatcg       60

aagtcattcg atctaagaag aatagaaggc ataggatgac aaagggaaga acataaggac      120

actaagagtt tttttggaac tcgagaa                                          147


<210>  43
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype17

<400>  43
aaggatccgc agcgatcgct cgtacaaaga ggcataggat gacaaaggga agaacaatcc       60

aagtcattgg attgaagaag aatagaaggc ataggatgac aaagggaaga atgtacgagc      120

gatcgctgct tttttggaac tcgagaa                                          147


<210>  44
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype18

<400>  44
aaggatccta ctaagacagt atctccaaga ggcataggat gacaaaggga agaagtctct       60

aggtcactag agacaagaag aatagaaggc ataggatgac aaagggaaga aggagatact      120

gtcttagtat tttttggaac tcgagaa                                          147


<210>  45
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype19

<400>  45
aaggatcctg cggcgcgact aaccgaaaga ggcataggat gacaaaggga agaaggtcac       60

tcgtcagagt gaccaagaag aatagaaggc ataggatgac aaagggaaga atcggttagt      120

cgcgccgcat tttttggaac tcgagaa                                          147


<210>  46
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype20

<400>  46
aaggatccta cctatatctc cacgttaaga ggcataggat gacaaaggga agaagacgaa       60

tcgtcagatt cgtcaagaag aatagaaggc ataggatgac aaagggaaga aaacgtggag      120

atataggtat tttttggaac tcgagaa                                          147


<210>  47
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype21

<400>  47
aaggatccga cgagtcgtag cgcagaaaga ggcataggat gacaaaggga agaacagttg       60

ctgtcaagca actgaagaag aatagaaggc ataggatgac aaagggaaga atctgcgcta      120

cgactcgtct tttttggaac tcgagaa                                          147


<210>  48
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype22

<400>  48
aaggatccgt aaatcaccct actgccaaga ggcataggat gacaaaggga agaaactctt       60

atgtcaataa gagtaagaag aatagaaggc ataggatgac aaagggaaga aggcagtagg      120

gtgatttact tttttggaac tcgagaa                                          147


<210>  49
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype23

<400>  49
aaggatccct aagttgttaa taattgaaga ggcataggat gacaaaggga agaaatgtgc       60

cggtcacggc acataagaag aatagaaggc ataggatgac aaagggaaga acaattatta      120

acaacttagt tttttggaac tcgagaa                                          147


<210>  50
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype24

<400>  50
aaggatccca gaccagccag atcggcaaga ggcataggat gacaaaggga agaacgcgaa       60

cggtcacgtt cgcgaagaag aatagaaggc ataggatgac aaagggaaga agccgatctg      120

gctggtctgt tttttggaac tcgagaa                                          147


<210>  51
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype25

<400>  51
aaggatcctg cgtaacgaag tgggggaaga ggcataggat gacaaaggga agaatagagg       60

aggtcactcc tctaaagaag aatagaaggc ataggatgac aaagggaaga acccccactt      120

cgttacgcat tttttggaac tcgagaa                                          147


<210>  52
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype26

<400>  52
aaggatccca cggtcctagt cttttgaaga ggcataggat gacaaaggga agaatcgtct       60

aagtcattag acgaaagaag aatagaaggc ataggatgac aaagggaaga acaaaagact      120

aggaccgtgt tttttggaac tcgagaa                                          147


<210>  53
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype27

<400>  53
aaggatccat agactgcgga ggcggtaaga ggcataggat gacaaaggga agaatacaaa       60

ctgtcaagtt tgtaaagaag aatagaaggc ataggatgac aaagggaaga aaccgcctcc      120

gcagtctatt tttttggaac tcgagaa                                          147


<210>  54
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype28

<400>  54
aaggatcctc aggtttaaac caacctaaga ggcataggat gacaaaggga agaaactgac       60

ctgtcaaggt cagtaagaag aatagaaggc ataggatgac aaagggaaga aaggttggtt      120

taaacctgat tttttggaac tcgagaa                                          147


<210>  55
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype29

<400>  55
aaggatcctc tgacatactt ggggaaaaga ggcataggat gacaaaggga agaaacttac       60

gagtcatcgt aagtaagaag aatagaaggc ataggatgac aaagggaaga attccccaag      120

tatgtcagat tttttggaac tcgagaa                                          147


<210>  56
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype30

<400>  56
aaggatccaa gagttaagta gcctgaaaga ggcataggat gacaaaggga agaaatcaat       60

aggtcactat tgataagaag aatagaaggc ataggatgac aaagggaaga atcaggctac      120

ttaactcttt tttttggaac tcgagaa                                          147


<210>  57
<211>  138
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RNA complex_204-5p_subtype31

<400>  57
aaggatccga cggcgctagg atcatcaaca ggcataggat gacaaaggga acaagtattc       60

tggtcacaga atacaacagg cataggatga caaagggaac aagatgatcc tagcgccgtc      120

ttttttggaa ctcgagaa                                                    138


<210>  58
<211>  1307
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nuclear receptor subfamily 4 group A member 2 (NR4A2)

<400>  58
gacctcctcc caagcacttc aaaggaactg gaatgataat ggaaactgtc aagagggggc       60

aagtcacatg ggcagagata gccgtgtgag cagtctcagc tcaagctgcc ccccatttct      120

gtaaccctcc tagccccctt gatccctaaa gaaaacaaac aaacaaacaa aaactgttgc      180

tatttcctaa cctgcaggca gaacctgaaa gggcattttg gctccggggc atcctggatt      240

tagaacatgg actacacaca atacagtggt ataaactttt tattctcagt ttaaaaatca      300

gtttgttgtt cagaagaaag attgctataa tgtataatgg gaaatgtttg gccatgcttg      360

gttgttgcag ttcagacaaa tgtaacacac acacacatac acacacacac acacacacag      420

agacacatct taaggggacc cacaagtatt gccctttaac aagacttcaa agttttctgc      480

tgtaaagaaa gctgtaatat atagtaaaac taaatgttgc gtgggtggca tgagttgaag      540

aaggcaaagg cttgtaaatt tacccaatgc agtttggctt tttaaattat tttgtgccta      600

tttatgaata aatattacaa attctaaaag ataagtgtgt ttgcaaaaaa aaagaaaata      660

aatacataaa aaagggacaa gcatgttgat tctaggttga aaatgttata ggcacttgct      720

acttcagtaa tgtctatatt atataaatag tatttcagac actatgtagt ctgttagatt      780

ttataaagat tggtagttat ctgagcttaa acattttctc aattgtaaaa taggtgggca      840

caagtattac acatcagaaa atcctgacaa aagggacaca tagtgtttgt aacaccgtcc      900

aacattcctt gtttgtaagt gttgtatgta ccgttgatgt tgataaaaag aaagtttata      960

tcttgattat tttgttgtct aaagctaaac aaaacttgca tgcagcagct tttgactgtt     1020

tccagagtgc ttataatata cataactccc tggaaataac tgagcacttt gaattttttt     1080

tatgtctaaa attgtcagtt aatttattat tttgtttgag taagaatttt aatattgcca     1140

tattctgtag tatttttctt tgtatatttc tagtatggca catgatatga gtcactgcct     1200

ttttttctat ggtgtatgac agttagagat gctgattttt tttctgataa attctttctt     1260

tgagaaagac aattttaatg tttacaacaa taaaccatgt aaatgaa                   1307


<210>  59
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1

<400>  59
atcctgacaa aagggacaca tagtg                                             25


<210>  60
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1

<400>  60
aatacataaa aaagggacaa gcatgt                                            26


<210>  61
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nurr1

<400>  61
aagcacttca aaggaactgg aatgat                                            26


<210>  62
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  62
uccguauccu acuguuuccc uu                                                22


<210>  63
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Isoform

<400>  63

Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser 
1               5                   10                  15      


Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser 
            20                  25                  30          


Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser Met Asp Leu Thr Asn 
        35                  40                  45              


Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser Phe Ser Thr Phe Met 
    50                  55                  60                  


Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln 
65                  70                  75                  80  


Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys Val Glu Asp Ile Gln 
                85                  90                  95      


Met His Asn Tyr Gln Gln His Ser His Leu Pro Pro Gln Ser Glu Glu 
            100                 105                 110         


Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro 
        115                 120                 125             


Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His Ser Pro Met Trp Asp 
    130                 135                 140                 


Asp Pro Gly Ser Leu His Asn Phe His Gln Asn Tyr Val Ala Thr Thr 
145                 150                 155                 160 


His Met Ile Glu Gln Arg Lys Thr Pro Val Ser Arg Leu Ser Leu Phe 
                165                 170                 175     


Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val Ser Ser Cys Gln Met 
            180                 185                 190         


Arg Phe Asp Gly Pro Leu His Val Pro Met Asn Pro Glu Pro Ala Gly 
        195                 200                 205             


Ser His His Val Val Asp Gly Gln Thr Phe Ala Val Pro Asn Pro Ile 
    210                 215                 220                 


Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu Gln Ile Gly His Ala 
225                 230                 235                 240 


Ser Gln Leu Leu Asp Thr Gln Val Pro Ser Pro Pro Ser Arg Gly Ser 
                245                 250                 255     


Pro Ser Asn Glu Gly Leu Cys Ala Val Cys Gly Asp Asn Ala Ala Cys 
            260                 265                 270         


Gln His Tyr Gly Val Arg Thr Cys Glu Gly Cys Lys Gly Phe Phe Lys 
        275                 280                 285             


Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn 
    290                 295                 300                 


Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe 
305                 310                 315                 320 


Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp 
                325                 330                 335     


Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro 
            340                 345                 350         


Gln Glu Pro Ser Pro Pro Ser Pro Pro Val Ser Leu Ile Ser Ala Leu 
        355                 360                 365             


Val Arg Ala His Val Asp Ser Asn Pro Ala Met Thr Ser Leu Asp Tyr 
    370                 375                 380                 


Ser Arg Phe Gln Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp Thr 
385                 390                 395                 400 


Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu Ile 
                405                 410                 415     


Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro Lys 
            420                 425                 430         


Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe Val 
        435                 440                 445             


Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile Phe 
    450                 455                 460                 


Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe Gly 
465                 470                 475                 480 


Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn Met 
                485                 490                 495     


Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met Val 
            500                 505                 510         


Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu Gln 
        515                 520                 525             


Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn Gly 
    530                 535                 540                 


Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu Pro 
545                 550                 555                 560 


Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr Leu 
                565                 570                 575     


Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu Phe 
            580                 585                 590         


Leu Asp Thr Leu Pro Phe 
        595             


<210>  64
<211>  147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  64
aactcgaggt tcgatacagg ggcatcaaga ggcataggat gacaaaggga agaatttgga       60

acgtcagttc caaaaagaag aatagaaggc ataggatgac aaagggaaga agatgcccct      120

gtatcgaact tttttggaac tcgagaa                                          147


<210>  65
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  65
aactcgaggt tcgatacagg ggcatcaaga agaggcttgc acagtgcatt gaatttggaa       60

cgtcagttcc aaaaagaaga atagaaagag gcttgcacag tgcattgaag atgcccctgt      120

atcgaacttt tttggaactc gagaa                                            145


