                         SEQUENCE LISTING

<110>  Nomad Bioscience GmbH
       UAB Nomads
 
<120>  Klebicins for the control of Klebsiella

<130>  PCT-17626

<150>  EP19178676.3
<151>  2019-06-06

<160>  58    

<170>  PatentIn version 3.5

<210>  1
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KpneM (K. pneumoniae EWD35590.1)

<400>  1

Met Ser Glu Thr Met Val Val Val Ala Thr Pro Thr Gly Phe Glu Pro 
1               5                   10                  15      


Ala Gly Tyr Gly Gly Gly Leu Phe Ser Pro Ser Thr Pro Asn His Ser 
            20                  25                  30          


Pro Ser Gln Gly Gln Ile Phe Leu Gln Val Thr Leu Pro Tyr Tyr Gln 
        35                  40                  45              


Ser Thr Lys Phe Cys Gln Asp Ser Met Ala Trp Leu Ala Gln Tyr Val 
    50                  55                  60                  


Lys Thr His Gly Ala Gln Asp Pro Leu Thr Ile Gln Val Val Ala Asn 
65                  70                  75                  80  


Asn Ile Arg Tyr Phe Leu Asn Ala Asp Thr Asn Leu Cys His Asn Pro 
                85                  90                  95      


Lys Gln Asn Val Trp Glu Ala Phe His Ser Glu Met Thr His Ser Gly 
            100                 105                 110         


Pro Pro Pro Ala Lys Tyr Asp Tyr His Ser Met Ser Leu Lys Gln Met 
        115                 120                 125             


Ser Gly Asn Val Val Thr Pro Ala Ala Ala Phe Gly His Tyr Leu Trp 
    130                 135                 140                 


Gly Asn Gly Glu Ala Arg Tyr Val Asn Leu Pro Asp Val Gly Leu Lys 
145                 150                 155                 160 


Ile Thr Pro Gln Met Ile Pro Glu Leu Met Asn Ile Val Asn Ser Gly 
                165                 170                 175     


Val Thr Gly His Ile Pro Val Asp Ile Lys Phe Val His Asp Thr Ser 
            180                 185                 190         


Val Ser Gly Gly Ile Val Pro Ala Ala Tyr Leu Gly His Ile Thr Leu 
        195                 200                 205             


Arg Thr Glu Gly Thr Leu Asp Ile Gln Ser Gly Gly Ala Trp Thr Tyr 
    210                 215                 220                 


Asn Gly Val Ala Arg Ala Phe Asn Asp Thr Tyr Asp Phe Asn Leu Gly 
225                 230                 235                 240 


Asp Phe Arg Gly Pro Ile Ala Glu Ser Met Thr Phe Leu Gly Ser Gln 
                245                 250                 255     


Phe Thr Gly Lys Gln Tyr Glu Ile Ser Met Pro Gly Gln Ile Asn Ile 
            260                 265                 270         


Ser Gly Ser Gly Arg Arg 
        275             


<210>  2
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KvarM (K. variicola CTQ17225.1)

<400>  2

Met Ser Asp Thr Met Ile Val Val Ala Thr Pro Thr Pro Gly Phe Ser 
1               5                   10                  15      


Tyr Ala Ser Gly Leu Thr Tyr Gly Gly Gly Ala Phe Ala Gly Ala Pro 
            20                  25                  30          


Ala Asn Gly Pro Ser Glu Gly Gln Ile Phe Phe Gln Thr Val Leu Pro 
        35                  40                  45              


Ala Tyr Gln Ser Pro Asn Leu Cys Ile Gly Gln Leu Ala Trp Met Thr 
    50                  55                  60                  


Asp Tyr Ile Asn Lys Asn Gly Val Gly Asn Pro Lys Thr Trp Glu Val 
65                  70                  75                  80  


Ile Ser Gln Asn Val Leu Ile Phe Cys Ser Ala Asp Thr Ala Leu Val 
                85                  90                  95      


Leu Asn Pro Arg Ile Ala Val Tyr Asp Gly Phe His Lys Thr Lys Trp 
            100                 105                 110         


Ala Pro Ala Lys Phe Asn Phe Lys Thr Gln Ser Gln Glu Lys Phe Ser 
        115                 120                 125             


Gly Asn Val Thr Thr Pro Ile Ala Ala Phe Gly His Tyr Leu Trp Gly 
    130                 135                 140                 


Glu Gly Lys Pro Arg Thr Val Asp Leu Ser Ser Val Gly Leu Lys Ile 
145                 150                 155                 160 


Gln Ala Asn Gln Ile Asp Pro Val Met Ile Ala Val Lys Asn Asn Ala 
                165                 170                 175     


Ala Gly Thr Tyr Gln Ile Ser Gly Asn Phe Asn Arg Asn Thr Phe Ile 
            180                 185                 190         


Asp Gly Asp Ile Pro Gly Leu Tyr Leu Gly Asn Ile Thr Met Lys Thr 
        195                 200                 205             


Glu Gly Thr Leu Lys Ile Asp Ala Lys Gly Asn Trp Asn Tyr Asn Gly 
    210                 215                 220                 


Val Val Arg Ala Phe Asn Asp Thr Tyr Asp Ala Asn Pro Ser Thr His 
225                 230                 235                 240 


Arg Ser Lys Ser Ala Glu Asp Leu Thr Thr Leu Leu Arg Leu Thr Gln 
                245                 250                 255     


Gly Thr Pro Tyr Glu Ile Arg Ile Pro Gly Glu Leu Lys Val Ser Gly 
            260                 265                 270         


Ser Gly Lys Lys 
        275     


<210>  3
<211>  272
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KpneM2 (Klebsiella sp. WP_047066220)

<400>  3

Met Ser Glu Thr Leu Val Val Val Ala Pro Ala Pro Ser Ala Pro Ser 
1               5                   10                  15      


Met Thr Tyr Gly Gly Gly Leu Ile Tyr Ser Ser Ile Pro Ser Gly Pro 
            20                  25                  30          


Asn Glu Gly Gln Ile Phe Phe Gln Thr Val Leu Pro Ala Tyr Ser Ser 
        35                  40                  45              


Pro Asn Phe Cys Thr Asp Arg Leu Arg Trp Met Val Lys Phe Ile Asn 
    50                  55                  60                  


Glu Asn Gly Val Gly Asn Pro Asp Thr Trp Lys Thr Leu Ala Asp Val 
65                  70                  75                  80  


Ile Arg Tyr Tyr Ala Ser Ala Asp Thr Ala Ile Ser Lys Asn Pro Lys 
                85                  90                  95      


Thr Asn Pro Tyr Asp Ala Trp His Lys Cys Pro Trp Pro Pro Ala Ser 
            100                 105                 110         


Phe Asp Val Lys Thr Met Ser Val Glu Lys Phe Ser Gly Ser Val Asn 
        115                 120                 125             


Thr Pro Ile Val Ala Phe Gly His Tyr Leu Trp Gly Glu Gly Lys Pro 
    130                 135                 140                 


Arg Ser Val Asp Leu Ser Thr Val Gly Leu Lys Val Gln Ala Asn Gln 
145                 150                 155                 160 


Ile Asp Pro Val Met Ile Ala Val Lys Ser Tyr Gly Ala Gly Thr Tyr 
                165                 170                 175     


Gln Ile Asn Gly Asn Phe Asn Arg Asn Thr Phe Asp Asp Gly Val Ile 
            180                 185                 190         


Pro Gly Leu Tyr Leu Gly Asn Ile Thr Leu Lys Thr Glu Gly Thr Leu 
        195                 200                 205             


Lys Ile Glu Lys Asn Gly Ser Trp Asn Tyr Asn Gly Val Ile Arg Ala 
    210                 215                 220                 


Phe Asn Asp Thr Tyr Asp Ala Asn Pro Ser Asn His Arg Ser Gln Ala 
225                 230                 235                 240 


Ala Glu Asp Leu Thr Thr Leu Leu Arg Ile Thr Gln Gly Thr Pro Tyr 
                245                 250                 255     


Glu Ile Arg Ile Pro Gly Glu Ile Lys Val Ser Gly Ser Gly Lys Lys 
            260                 265                 270         


<210>  4
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KaerM (K. aerogenes WP_015367360.1)

<400>  4

Met Thr Asp Thr Leu Thr Val Thr Ala Thr Ile Pro Asn Gly Ser Ser 
1               5                   10                  15      


Phe Asn Phe Gln Phe Glu Gly Met Gly Asn Tyr Tyr Ala Ala Gly Ser 
            20                  25                  30          


Ser Thr Trp Asp Asp Pro Ala Met Ala Asp Ala Ala His Leu Tyr Asn 
        35                  40                  45              


Ala Ile Gln Ser Met Glu Asp Gly Ser Phe Thr Lys Ala Leu Phe Ala 
    50                  55                  60                  


Asp Trp Leu Gln Phe Asn Ala Lys Gly Arg Glu Asn Ile Pro Met Ile 
65                  70                  75                  80  


Asn Ala Arg Phe Ala Thr Met Glu Thr Met Arg Phe Asn Asp Pro Gly 
                85                  90                  95      


Lys Ala Tyr Phe Gln Phe Ala Gln Tyr Asn Glu Tyr Glu Gly His Thr 
            100                 105                 110         


Pro Gly Asn Asn Phe Thr Ser Gly Ala Phe Ala Pro Phe Leu Gly Leu 
        115                 120                 125             


Trp His Tyr Ile Ser Gly Asn Gly Val Glu Thr Ser Leu Asp Ile Thr 
    130                 135                 140                 


Thr Ile Gly Leu Thr Phe Asn Gln Ser Asn Leu Thr Pro Val Asn Asp 
145                 150                 155                 160 


Ala Leu Lys Ser Gln Pro Pro Gly Asn Tyr Pro Ile Ser Ser Asn Phe 
                165                 170                 175     


Gly Lys Ser Val Ala Glu Asp Asn Leu Tyr Val Ala Ala Leu Leu Gly 
            180                 185                 190         


Arg Ile Ser Met Lys Thr Glu Gly Thr Leu Ser Ile Gly Glu Ser Gly 
        195                 200                 205             


Glu Trp Ser Tyr Asn Gly Val Val Arg Ala Tyr Asn Asp Thr Tyr Asp 
    210                 215                 220                 


Ala Asn Phe Asp Pro Ser Arg Gly Val Ile Ala Gln Ala Ser Thr Thr 
225                 230                 235                 240 


Val Leu Ser Trp Phe Asn Gly Lys Pro Tyr Pro Ile Ala Leu Pro Gly 
                245                 250                 255     


Glu Ile Pro Val Gln Leu Ser Gly His Arg 
            260                 265     


<210>  5
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KpneA (K. pneumoniae SAV78255.1)

<400>  5

Met Pro Glu Glu Thr Leu Thr Val Val Gly Gly Gly Asn Asn Ser Cys 
1               5                   10                  15      


Asn Val Ser Trp Gly Gly Gly Asn Gly Asn Asn Gly Gly Ala Gly Tyr 
            20                  25                  30          


Ser Gly Lys Tyr Gly Gly Thr Ser Tyr Glu Gly Ala Thr Ser Met Leu 
        35                  40                  45              


Lys Leu Asn Asp Arg Val Leu Ile Gln Leu Tyr Leu Cys Asn Pro Leu 
    50                  55                  60                  


Asn Pro Asp Tyr Ile Gly Ala Pro Trp Gly Ser Asp Lys Asp Ala Glu 
65                  70                  75                  80  


Ser Ile Ile Arg Ala Asn Arg Asp Lys Pro Gly Lys Phe Lys Ala Asn 
                85                  90                  95      


Ile Gln Asn Trp Lys Thr Ser Gly Thr Gly Ser Leu Gly Ser Pro Val 
            100                 105                 110         


Val Gly Lys Ser Tyr Ser Ser Gly Asp Val Asp Thr Tyr Ser Val Ser 
        115                 120                 125             


Phe Gly Lys Glu Lys Tyr Asn Val Leu Tyr Asn Arg Lys Lys Asp Ser 
    130                 135                 140                 


Phe Thr Thr Ala Tyr Val Asp Gly Gly Ala Asn Lys Pro Glu His Ser 
145                 150                 155                 160 


Met Lys Asp Gln Ala Ile Ala Val Val Lys Leu Tyr Leu Leu Asn Glu 
                165                 170                 175     


Ser Gln Ala Ser Val Ile Asp Thr Thr Ser Gly Ile Ile Thr Asp Ser 
            180                 185                 190         


Gly Lys Thr Leu Ser Gly Lys Leu Gly Asp Lys Tyr Asn Thr Leu Ala 
        195                 200                 205             


Arg Glu Ala Ala Asp Asn Ile Lys Asn Phe Gln Gly Lys Lys Leu Arg 
    210                 215                 220                 


Ser Phe Asn Asp Ala Met Ala Ser Ile Asn Glu Leu Ala Asn Asn Pro 
225                 230                 235                 240 


Lys Met Lys Leu Ser Gln Ala Asp Lys Thr Val Val Ser Asn Ala Leu 
                245                 250                 255     


Lys Gln Met Asp Leu Ser Ala Leu Ala Asp Arg Phe Lys Gly Leu Glu 
            260                 265                 270         


Lys Ala Phe Thr Trp Gly Asp Arg Leu Leu Lys Ala Glu Lys Ile Arg 
        275                 280                 285             


Asp Gly Val Val Thr Gly Val Thr Thr Gly Asp Trp Gln Lys Leu Ala 
    290                 295                 300                 


Phe Glu Val Glu Ala Met Tyr Leu Ser Gly Val Ala Gly Ala Val Ala 
305                 310                 315                 320 


Leu Gly Ile Thr Thr Ala Met Ile Ser Thr Val Ala Val Ala Leu Ser 
                325                 330                 335     


Leu Pro Ser Val Ala Val Ser Ala Leu Thr Val Val Ala Val Ile Gly 
            340                 345                 350         


Ile Ser Ile Leu Thr Ser Tyr Ile Asp Ala Asp Lys Ala Lys Ala Leu 
        355                 360                 365             


Asn Asn Ala Val Leu Gly Leu Phe Lys 
    370                 375         


<210>  6
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KaerA (K. aerogenes WP_063414841.1)

<400>  6

Met Ala Asn Glu Asp Ser Met Thr Val Asn Gly Asn Ala Gly Ser Gly 
1               5                   10                  15      


Val His Trp Gly Gly Gly Ser Gly Asn Gly Asn Asn Gly Gly Ala Gly 
            20                  25                  30          


Ser Asn Gly Gly Ala Asn Val Ala Leu Gly Gly Thr Met Glu Val Glu 
        35                  40                  45              


Leu Gly Asn Gly Phe Thr Met Ile Val Asp Gly Thr His Pro Ile Asn 
    50                  55                  60                  


Pro Gly Ile Gly Gly Ala Pro Trp Ser Asp Asp Lys Ser Asn Lys Ser 
65                  70                  75                  80  


Ala Val Asp Ala Leu Asn Ala Asn Lys Ser Lys Pro Ala Lys Phe Lys 
                85                  90                  95      


Ala Asn Ile Gln Asn Tyr Lys Ser Gly Thr Gln Gly Ser Leu Asn Ser 
            100                 105                 110         


Pro Ala Val Asn Lys Ser Ser Ser Ser Gly Asp Val Asp Thr Tyr Ala 
        115                 120                 125             


Val Ser Phe Gly Lys Glu Lys Tyr Asn Val Met Tyr Asn Arg Lys Lys 
    130                 135                 140                 


Asp Ser Phe Thr Ser Gly Tyr Val Asp Gly Gly Ala Thr Lys Pro Glu 
145                 150                 155                 160 


His Ser Met Lys Asp Gln Ala Ile Ala Val Val Gln Leu Tyr Leu Leu 
                165                 170                 175     


Asn Glu Lys Glu Lys Asp Val Ile Thr Thr Ala Ala Glu Ile Ile Ser 
            180                 185                 190         


Ser Ser Gly Glu Thr Ile Ser Gly Lys Leu Gly Glu Lys Tyr Lys Gly 
        195                 200                 205             


Leu Ala Gln Gly Val Ala Asn Asp Ile Arg Asn Phe Gln Gly Lys Lys 
    210                 215                 220                 


Ile Arg Ser Phe Lys Asp Ala Met Ser Ser Leu Glu Gln Phe Thr Lys 
225                 230                 235                 240 


Asn Pro Asn Met Lys Leu Asn Gln Ala Asp Lys Ala Ala Leu Val Asn 
                245                 250                 255     


Ala Leu Asn Gln Val Asn Leu Ser Thr Leu Ala Asp Arg Phe Lys Gly 
            260                 265                 270         


Leu Glu Arg Ala Phe Thr Trp Ala Asp Arg Leu Leu Lys Ala Gln Lys 
        275                 280                 285             


Ile Lys Asp Gly Val Val Thr Gly Val Thr Thr Gly Asn Trp Gln Pro 
    290                 295                 300                 


Leu Ala Leu Glu Val Glu Ala Met Tyr Leu Ser Gly Val Ala Gly Ser 
305                 310                 315                 320 


Val Ala Leu Gly Ile Val Thr Gly Met Ile Ser Gly Leu Ala Ala Leu 
                325                 330                 335     


Ile Ser Ile Pro Ala Leu Ala Val Thr Ala Leu Thr Val Thr Ala Val 
            340                 345                 350         


Ile Gly Ile Ala Ile Ala Thr Ser Tyr Ile Asn Ala Asp Thr Ala Lys 
        355                 360                 365             


Ala Leu Asn Asn Ala Val Ala Asp Leu Phe Lys 
    370                 375                 


<210>  7
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as Koxy (K. oxytoca WP_024273778)

<400>  7

Met Ala Gly Phe Ser Tyr Gly Gly Phe Gly Asp Gly Thr Thr Trp Ser 
1               5                   10                  15      


Lys Glu Arg Gly Thr Gly Pro Leu Pro Gly Gly Gly Ser Ser Gly Asn 
            20                  25                  30          


Ser Gly Asn His Ser Asn Thr Thr Pro Ala Glu Gln Lys Gln Ile Asn 
        35                  40                  45              


Ala Ile Arg Ala Asp Lys Asn Val Arg Ala Arg Leu Ser Asn Leu Ile 
    50                  55                  60                  


Lys Ala Ala Arg Lys Leu Asn Pro Ser Val Lys Ile Thr Val His Ala 
65                  70                  75                  80  


Ile Ser Pro Glu Gly Thr Met Ala Ile Ser Met Glu Gly Leu Thr Ala 
                85                  90                  95      


Thr Gln Ala Arg Gln Ala Gly Leu Thr Gly Leu Val Met Gly Ile Thr 
            100                 105                 110         


Val Pro Gly Tyr Ile Gly Ser Val Gly Asp Phe Glu Thr Gly His Lys 
        115                 120                 125             


Tyr Asn Leu Lys Asn Pro Glu Lys Leu Asn Ser Ile Gly Val Gly Thr 
    130                 135                 140                 


Pro Leu Asp Gly Phe Asn Gly Gly Glu Asn Ile Asp Thr Thr Pro Lys 
145                 150                 155                 160 


Lys Tyr Arg Asn Trp Arg Ala Thr Asp Glu Lys Ser Phe Tyr Tyr Val 
                165                 170                 175     


Gly Thr Thr Val Pro Met Arg Leu Leu His His Leu Thr Val Ser Arg 
            180                 185                 190         


Asn Lys Glu Thr Asp Thr Tyr Thr Met Tyr Phe Lys Ala Lys Asp Ile 
        195                 200                 205             


Lys Ala Leu Tyr Lys Ile Glu Val Lys Asn Gly Asp Leu Asp Asn Met 
    210                 215                 220                 


Lys Leu Thr Thr Leu Ala Gln Gly His Pro Leu Phe Thr Ala Glu Phe 
225                 230                 235                 240 


Ala Lys Asp Ile Val Arg Asn Phe Ala Ser Val Lys Asn Glu Ser Asp 
                245                 250                 255     


Lys Glu Val Leu Asp Lys Thr Ser Gly Val Ile Ile Ser Val Gly Asp 
            260                 265                 270         


Lys Ala Gly Ala Leu Leu Gly Glu Lys Tyr Lys Ala Leu Ser Arg Glu 
        275                 280                 285             


Val Ala Ser Asn Ile Gln Asn Phe Gln Gly Lys Gln Ile Arg Thr Tyr 
    290                 295                 300                 


Asp Gln Ala Met Ala Ser Met Asn Lys Leu Met Thr Asn Pro Asn Met 
305                 310                 315                 320 


Lys Ile Lys Ala Ala Asp Lys Thr Ala Val Ile Asn Ala Trp Lys Ala 
                325                 330                 335     


Phe Asn Val Glu Asp Met Gly Asn Lys Phe Thr Ala Leu Gly Arg Ala 
            340                 345                 350         


Phe Lys Val Ala Asp Tyr Val Thr Lys Gly Asn Asn Val Arg Glu Lys 
        355                 360                 365             


Ser Ile Thr Gly Tyr Glu Thr Gly Asn Trp Gly Pro Leu Met Arg Glu 
    370                 375                 380                 


Val Glu Ser Trp Thr Val Ser Gly Leu Thr Ser Ser Val Ala Leu Ala 
385                 390                 395                 400 


Val Phe Ser Ala Thr Leu Gly Ala Met Leu Val Ala Ala Gly Val Ser 
                405                 410                 415     


Thr Ala Val Val Gly Ile Ile Gly Ile Ile Ile Ala Gly Leu Ile Gly 
            420                 425                 430         


Ala Leu Ile Asp Asp Lys Phe Ile Asp Lys Leu Asn Asn Glu Ile Ile 
        435                 440                 445             


Arg Pro Ala Tyr 
    450         


<210>  8
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KpneIa (K. pneumoniae BAS34675)

<400>  8

Met Pro Gly Phe Asn Tyr Gly Gly Lys Gly Asp Gly Thr Asn Trp Ser 
1               5                   10                  15      


Ser Glu Arg Gly Thr Gly Pro Glu Pro Gly Gly Gly Ser Arg Gly Asn 
            20                  25                  30          


Gly Gly Asp Arg Asp Asn Ser Arg Gly Gly Ala Gly Asn Arg Gly Asn 
        35                  40                  45              


Trp Ala Gly Ser Gly Pro Leu Ser Ala Ala Leu Ile Asn Asp Ser Ile 
    50                  55                  60                  


Ala Glu Ala Leu Glu Lys Gln Leu Pro Arg Asn Thr Val Glu Ala Thr 
65                  70                  75                  80  


Ser Thr Pro Ala Tyr Lys Lys Met Arg Ala Ala Phe Asp Ala Leu Pro 
                85                  90                  95      


Leu Asp Lys Gln Pro Glu Ala Arg Ala Gln Ile Thr Lys Ala Trp Gln 
            100                 105                 110         


Ser Ala His Asp Ala Met Pro Asp Lys Thr Thr Thr Thr Glu Asn Val 
        115                 120                 125             


Gly Gly Gly Lys Asn Gly His Asn Val Thr Arg Ser Thr Pro Asn Trp 
    130                 135                 140                 


Leu Lys Glu Lys Met Lys Gly Leu Asn Gln Gln Val Asn Asn Asp Leu 
145                 150                 155                 160 


Ser Gly Ala Leu Ala Gln His Gln Lys Ala Glu Ala Asp Ala Arg Ala 
                165                 170                 175     


Lys Ala Glu Ala Ala Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala 
            180                 185                 190         


Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Lys Ala Glu Ala Ala Ala 
        195                 200                 205             


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Glu Ala 
    210                 215                 220                 


Lys Ala Lys Ala Glu Ala Ala Ala Lys Ala Lys Ala Glu Ala Glu Ala 
225                 230                 235                 240 


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Ala Ala 
                245                 250                 255     


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Glu Ala 
            260                 265                 270         


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Asp Ala 
        275                 280                 285             


Val Lys Asp Ala Val Lys Phe Thr Ala Asp Phe Tyr Lys Glu Val Phe 
    290                 295                 300                 


Ser Val Tyr Gly Glu Lys Ala Glu Gln Leu Ala Asn Leu Leu Ala Thr 
305                 310                 315                 320 


Gln Ala Lys Gly Lys Asn Ile Arg Asn Ile Asp Asp Ala Leu Lys Ala 
                325                 330                 335     


Tyr Glu Lys His Lys Thr Asn Ile Asn Lys Lys Ile Asn Ala Gln Asp 
            340                 345                 350         


Arg Ala Ala Ile Ala Lys Ala Leu Glu Ser Val Asp Val Lys Glu Ala 
        355                 360                 365             


Ala Lys Asn Phe Ala Lys Phe Ser Lys Gly Leu Gly Tyr Val Gly Pro 
    370                 375                 380                 


Thr Met Asp Val Val Asp Leu Val Leu Glu Leu Arg Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Asp Asn Trp Arg Ser Phe Phe Val Lys Ile Glu Ala Ile Ala Ile 
                405                 410                 415     


Ser Phe Gly Ala Thr Gln Leu Ala Ala Leu Ala Phe Ala Ser Leu Leu 
            420                 425                 430         


Gly Ala Pro Val Gly Leu Leu Gly Tyr Ala Leu Ile Met Ala Gly Ile 
        435                 440                 445             


Gly Ala Leu Val Ser Asp Asp Val Val Asp Ala Ala Asn Lys Ile Ile 
    450                 455                 460                 


Gly Ile 
465     


<210>  9
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  referred to as KvarIa (K. variicola KDL88409)

<400>  9

Met Pro Gly Phe Asn Tyr Gly Gly Lys Gly Asp Gly Thr Asn Trp Ser 
1               5                   10                  15      


Ser Glu Arg Gly Thr Gly Pro Glu Pro Gly Gly Gly Ser Arg Gly Asn 
            20                  25                  30          


Gly Gly Asp Arg Asp Asn Ser Arg Gly Gly Ala Gly Asn Arg Gly Asn 
        35                  40                  45              


Trp Ala Gly Ser Gly Pro Leu Ser Ala Ala Leu Ile Asn Asp Ser Ile 
    50                  55                  60                  


Ala Glu Ala Leu Glu Lys Gln Leu Pro Arg Asn Thr Val Glu Ala Thr 
65                  70                  75                  80  


Ser Thr Pro Ala Tyr Lys Lys Met Arg Ala Ala Phe Asp Ala Leu Pro 
                85                  90                  95      


Leu Asp Lys Gln Pro Glu Ala Arg Ala Gln Ile Thr Lys Ala Trp Gln 
            100                 105                 110         


Ser Ala His Asp Ala Met Pro Asp Arg Thr Thr Thr Thr Glu Asn Val 
        115                 120                 125             


Gly Gly Gly Lys Asn Gly His Asn Val Thr Arg Ser Thr Pro Asn Trp 
    130                 135                 140                 


Leu Lys Glu Lys Met Lys Gly Leu Asn Gln Gln Val Asn Asn Asp Leu 
145                 150                 155                 160 


Ser Gly Ala Leu Ala Gln His Gln Lys Ala Glu Ala Asp Ala Arg Ala 
                165                 170                 175     


Lys Ala Glu Ala Ala Ala Lys Ala Lys Ala Ala Ala Lys Ala Lys Ala 
            180                 185                 190         


Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala 
        195                 200                 205             


Glu Ala Ala Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala 
    210                 215                 220                 


Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Asp Ala Val Lys Asp Ala 
225                 230                 235                 240 


Val Lys Phe Thr Ala Asp Phe Tyr Lys Glu Val Phe Ser Val Tyr Gly 
                245                 250                 255     


Glu Lys Ala Glu Gln Leu Ala Asn Leu Leu Ala Thr Gln Ala Lys Gly 
            260                 265                 270         


Lys Asn Ile Arg Asn Ile Asp Asp Ala Leu Lys Ala Tyr Glu Lys His 
        275                 280                 285             


Lys Thr Asn Ile Asn Lys Lys Ile Asn Ala Gln Asp Arg Ala Ala Ile 
    290                 295                 300                 


Ala Lys Ala Leu Glu Ser Val Asp Val Lys Glu Ala Ala Lys Asn Phe 
305                 310                 315                 320 


Ala Lys Phe Ser Lys Gly Leu Gly Tyr Val Gly Pro Thr Met Asp Val 
                325                 330                 335     


Val Asp Leu Val Leu Glu Leu Arg Lys Ala Ile Lys Glu Asp Asn Trp 
            340                 345                 350         


Arg Thr Phe Phe Val Lys Ile Glu Ala Ile Ala Ile Ser Phe Gly Ala 
        355                 360                 365             


Thr Gln Leu Ala Ala Leu Ala Phe Ala Ser Leu Leu Gly Ala Pro Val 
    370                 375                 380                 


Gly Leu Leu Gly Tyr Ala Leu Ile Met Ala Gly Ile Gly Ala Leu Val 
385                 390                 395                 400 


Ser Asp Asp Val Val Asp Ala Ala Asn Lys Ile Ile Gly Ile 
                405                 410                 


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ExbB Eco88I fwd

<400>  10
aaactcgggt tgatgaacct gtttttatac gtct                                   34


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ExbB Eco81I rev

<400>  11
aaacctgagg tcaacctacc cgtaatttct gcg                                    33


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ExbB Eco88I fwd

<400>  12
aaactcgggt tgatgaacct gtttttatac gtct                                   34


<210>  13
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer ExbD Eco81I rev

<400>  13
aaacctgagg ttatttggct ttgacggtct c                                      31


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FhuA Eco81I fwd

<400>  14
aaacctcagg tttaagccct aagaccagac cc                                     32


<210>  15
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FhuA Eco 81I rev

<400>  15
aaacctgagg ttagaaacgg aaggtggcgg tg                                     32


<210>  16
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FimB Eco88I fwd

<400>  16
aaactcgggg ctcccgtagc aaataaaaac g                                      31


<210>  17
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FimB Eco81I rev

<400>  17
aaacctgagg ttactgaagc agcgacaggc g                                      31


<210>  18
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer OmpC Eco88I fwd

<400>  18
aaactcgggc ttgtggctga acgactcatc a                                      31


<210>  19
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer OmpC Eco81I rev

<400>  19
aaacctgagg ttagaactgg taaaccaggc cc                                     32


<210>  20
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer TonB PsyI fwd

<400>  20
aaagaccggg tcggcaaagc tccttatcaa taaaca                                 36


<210>  21
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer TonB BseSI rev

<400>  21
aaagtgccct cagttaatct cgacgccgtt g                                      31


<210>  22
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus M (KpneM2, KvarM, KpneM, KaerM)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (81)..(81)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (108)..(109)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (115)..(115)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (117)..(118)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (143)..(143)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (173)..(174)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (179)..(179)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (190)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (196)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (213)..(215)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (217)..(217)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (237)..(237)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(241)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (251)..(253)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (256)..(256)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Met Ser Xaa Thr Xaa Val Val Val Ala Thr Pro Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Thr Tyr Gly Gly Gly Leu Phe Tyr Xaa Xaa Xaa Pro Xaa 
            20                  25                  30          


Gly Pro Ser Glu Gly Gln Ile Phe Phe Gln Thr Val Leu Pro Ala Tyr 
        35                  40                  45              


Gln Ser Pro Asn Phe Cys Xaa Asp Xaa Leu Ala Trp Met Ala Asp Tyr 
    50                  55                  60                  


Ile Asn Xaa Asn Gly Val Gly Asn Pro Xaa Thr Trp Glu Val Ile Ala 
65                  70                  75                  80  


Xaa Asn Ile Arg Tyr Phe Ala Ser Ala Asp Thr Ala Leu Xaa Xaa Asn 
                85                  90                  95      


Pro Lys Xaa Xaa Val Tyr Asp Ala Phe His Lys Xaa Xaa Trp Pro Pro 
            100                 105                 110         


Ala Lys Xaa Asp Xaa Xaa Thr Met Ser Xaa Glu Lys Phe Ser Gly Asn 
        115                 120                 125             


Val Xaa Thr Pro Ile Ala Ala Phe Gly His Tyr Leu Trp Gly Xaa Gly 
    130                 135                 140                 


Lys Pro Arg Ser Val Asp Leu Ser Thr Val Gly Leu Lys Ile Gln Ala 
145                 150                 155                 160 


Asn Gln Ile Asp Pro Val Met Ile Ala Val Lys Ser Xaa Xaa Ala Gly 
                165                 170                 175     


Thr Tyr Xaa Ile Ser Gly Asn Phe Asn Arg Asn Thr Phe Xaa Asp Gly 
            180                 185                 190         


Xaa Ile Pro Xaa Xaa Tyr Leu Gly Asn Ile Thr Xaa Lys Thr Glu Gly 
        195                 200                 205             


Thr Leu Lys Ile Xaa Xaa Xaa Gly Xaa Trp Asn Tyr Asn Gly Val Val 
    210                 215                 220                 


Arg Ala Phe Asn Asp Thr Tyr Asp Ala Asn Pro Ser Xaa His Arg Xaa 
225                 230                 235                 240 


Xaa Ile Ala Glu Asp Leu Thr Thr Leu Leu Xaa Xaa Xaa Gln Gly Xaa 
                245                 250                 255     


Pro Tyr Glu Ile Arg Ile Pro Gly Glu Ile Lys Val Ser Gly Ser Gly 
            260                 265                 270         


Lys Xaa 
        


<210>  23
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus A (KaerA, KpneA)


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (66)..(66)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (69)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (88)..(88)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (92)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (117)..(117)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (119)..(119)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (131)..(131)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (142)..(142)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (152)..(153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (160)..(160)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (182)..(182)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (184)..(185)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (188)..(188)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (190)..(192)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (195)..(196)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (201)..(201)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (210)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (214)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (228)..(228)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (232)..(232)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (236)..(236)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (238)..(238)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (241)..(243)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (246)..(246)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (255)..(258)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (268)..(268)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (283)..(283)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (293)..(293)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (307)..(307)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (310)..(310)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (323)..(323)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (331)..(331)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (335)..(336)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (338)..(339)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  VARIANT
<222>  (340)..(340)
<223>  Leu or Ile

<220>
<221>  VARIANT
<222>  (342)..(342)
<223>  Leu or Ile

<220>
<221>  misc_feature
<222>  (344)..(345)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (353)..(353)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (361)..(361)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (369)..(369)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (378)..(379)
<223>  Xaa can be any naturally occurring amino acid

<400>  23

Met Xaa Xaa Glu Xaa Xaa Xaa Xaa Val Xaa Gly Xaa Asn Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Val Xaa Trp Gly Gly Xaa Xaa Gly Asn Gly Asn Asn Gly Gly Ala 
            20                  25                  30          


Gly Xaa Xaa Gly Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Gly Xaa Thr Xaa 
        35                  40                  45              


Xaa Xaa Xaa Leu Xaa Asx Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Pro Xaa Asn Pro Xaa Xaa Xaa Gly Ala Pro Trp Xaa Xaa Xaa Xaa Ser 
65                  70                  75                  80  


Asx Lys Xaa Ala Xaa Xaa Xaa Xaa Xaa Ala Asn Xaa Xaa Lys Pro Xaa 
                85                  90                  95      


Lys Phe Lys Ala Asn Ile Gln Asn Xaa Lys Xaa Xaa Xaa Xaa Gly Ser 
            100                 105                 110         


Leu Xaa Ser Pro Xaa Val Xaa Lys Ser Xaa Ser Ser Gly Asp Val Asp 
        115                 120                 125             


Thr Tyr Xaa Val Ser Phe Gly Lys Glu Lys Tyr Asn Val Xaa Tyr Asn 
    130                 135                 140                 


Arg Lys Lys Asp Ser Phe Thr Xaa Xaa Tyr Val Asp Gly Gly Ala Xaa 
145                 150                 155                 160 


Lys Pro Glu His Ser Met Lys Asp Gln Ala Ile Ala Val Val Xaa Leu 
                165                 170                 175     


Tyr Leu Leu Asn Glu Xaa Glx Xaa Xaa Val Ile Xaa Thr Xaa Xaa Xaa 
            180                 185                 190         


Ile Ile Xaa Xaa Ser Gly Xaa Thr Xaa Ser Gly Lys Leu Gly Xaa Lys 
        195                 200                 205             


Tyr Xaa Xaa Leu Ala Xaa Xaa Xaa Ala Asx Asx Ile Xaa Asn Phe Gln 
    210                 215                 220                 


Gly Lys Lys Xaa Arg Ser Phe Xaa Asp Ala Met Xaa Ser Xaa Xaa Glx 
225                 230                 235                 240 


Xaa Xaa Xaa Asn Pro Xaa Met Lys Leu Xaa Gln Ala Asp Lys Xaa Xaa 
                245                 250                 255     


Xaa Xaa Asn Ala Leu Xaa Gln Xaa Asx Leu Ser Xaa Leu Ala Asp Arg 
            260                 265                 270         


Phe Lys Gly Leu Glu Xaa Ala Phe Thr Trp Xaa Asp Arg Leu Leu Lys 
        275                 280                 285             


Ala Glx Lys Ile Xaa Asp Gly Val Val Thr Gly Val Thr Thr Gly Asx 
    290                 295                 300                 


Trp Gln Xaa Leu Ala Xaa Glu Val Glu Ala Met Tyr Leu Ser Gly Val 
305                 310                 315                 320 


Ala Gly Xaa Val Ala Leu Gly Ile Xaa Thr Xaa Met Ile Ser Xaa Xaa 
                325                 330                 335     


Ala Xaa Xaa Xaa Ser Xaa Pro Xaa Xaa Ala Val Xaa Ala Leu Thr Val 
            340                 345                 350         


Xaa Ala Val Ile Gly Ile Xaa Ile Xaa Thr Ser Tyr Ile Asx Ala Asp 
        355                 360                 365             


Xaa Ala Lys Ala Leu Asn Asn Ala Val Xaa Xaa Leu Phe Lys 
    370                 375                 380         


<210>  24
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus Ia (KpneIa, KvarIa)


<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (186)..(237)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (239)..(239)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Met Pro Gly Phe Asn Tyr Gly Gly Lys Gly Asp Gly Thr Asn Trp Ser 
1               5                   10                  15      


Ser Glu Arg Gly Thr Gly Pro Glu Pro Gly Gly Gly Ser Arg Gly Asn 
            20                  25                  30          


Gly Gly Asp Arg Asp Asn Ser Arg Gly Gly Ala Gly Asn Arg Gly Asn 
        35                  40                  45              


Trp Ala Gly Ser Gly Pro Leu Ser Ala Ala Leu Ile Asn Asp Ser Ile 
    50                  55                  60                  


Ala Glu Ala Leu Glu Lys Gln Leu Pro Arg Asn Thr Val Glu Ala Thr 
65                  70                  75                  80  


Ser Thr Pro Ala Tyr Lys Lys Met Arg Ala Ala Phe Asp Ala Leu Pro 
                85                  90                  95      


Leu Asp Lys Gln Pro Glu Ala Arg Ala Gln Ile Thr Lys Ala Trp Gln 
            100                 105                 110         


Ser Ala His Asp Ala Met Pro Asp Xaa Thr Thr Thr Thr Glu Asn Val 
        115                 120                 125             


Gly Gly Gly Lys Asn Gly His Asn Val Thr Arg Ser Thr Pro Asn Trp 
    130                 135                 140                 


Leu Lys Glu Lys Met Lys Gly Leu Asn Gln Gln Val Asn Asn Asp Leu 
145                 150                 155                 160 


Ser Gly Ala Leu Ala Gln His Gln Lys Ala Glu Ala Asp Ala Arg Ala 
                165                 170                 175     


Lys Ala Glu Ala Ala Ala Lys Ala Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Ala 
225                 230                 235                 240 


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Xaa Ala 
                245                 250                 255     


Lys Ala Lys Ala Glu Ala Xaa Ala Lys Ala Lys Ala Glu Ala Glu Ala 
            260                 265                 270         


Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Asp Ala 
        275                 280                 285             


Val Lys Asp Ala Val Lys Phe Thr Ala Asp Phe Tyr Lys Glu Val Phe 
    290                 295                 300                 


Ser Val Tyr Gly Glu Lys Ala Glu Gln Leu Ala Asn Leu Leu Ala Thr 
305                 310                 315                 320 


Gln Ala Lys Gly Lys Asn Ile Arg Asn Ile Asp Asp Ala Leu Lys Ala 
                325                 330                 335     


Tyr Glu Lys His Lys Thr Asn Ile Asn Lys Lys Ile Asn Ala Gln Asp 
            340                 345                 350         


Arg Ala Ala Ile Ala Lys Ala Leu Glu Ser Val Asp Val Lys Glu Ala 
        355                 360                 365             


Ala Lys Asn Phe Ala Lys Phe Ser Lys Gly Leu Gly Tyr Val Gly Pro 
    370                 375                 380                 


Thr Met Asp Val Val Asp Leu Val Leu Glu Leu Arg Lys Ala Ile Lys 
385                 390                 395                 400 


Glu Asp Asn Trp Arg Xaa Phe Phe Val Lys Ile Glu Ala Ile Ala Ile 
                405                 410                 415     


Ser Phe Gly Ala Thr Gln Leu Ala Ala Leu Ala Phe Ala Ser Leu Leu 
            420                 425                 430         


Gly Ala Pro Val Gly Leu Leu Gly Tyr Ala Leu Ile Met Ala Gly Ile 
        435                 440                 445             


Gly Ala Leu Val Ser Asp Asp Val Val Asp Ala Ala Asn Lys Ile Ile 
    450                 455                 460                 


Gly Ile 
465     


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 22

<400>  25

Thr Glu Gly Thr Leu 
1               5   


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 22

<400>  26

Tyr Asn Gly Val 
1               


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 22

<400>  27

Arg Ala Phe Asn Asp Thr Tyr Asp 
1               5               


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  28

Gly Asn Gly Asn Asn Gly Gly Ala Gly 
1               5                   


<210>  29
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  29

Gly Ala Pro Trp 
1               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  30

Lys Phe Lys Ala Asn Ile Gln Asn 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  31

Ser Ser Gly Asp Val Asp Thr Tyr 
1               5               


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  32

Val Ser Phe Gly Lys Glu Lys Tyr Asn Val 
1               5                   10  


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  33

Tyr Asn Arg Lys Lys Asp Ser Phe Thr 
1               5                   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  34

Tyr Val Asp Gly Gly Ala 
1               5       


<210>  35
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  35

Lys Pro Glu His Ser Met Lys Asp Gln Ala Ile Ala Val Val 
1               5                   10                  


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  36

Leu Tyr Leu Leu Asn Glu 
1               5       


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  37

Ser Gly Lys Leu Gly 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  38

Asn Phe Gln Gly Lys Lys 
1               5       


<210>  39
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  39

Gln Ala Asp Lys 
1               


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  40

Leu Ala Asp Arg Phe Lys Gly Leu 
1               5               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  41

Ala Phe Thr Trp 
1               


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  42

Asp Arg Leu Leu Lys Ala 
1               5       


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  43

Asp Gly Val Val Thr Gly Val Thr Thr Gly 
1               5                   10  


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  44

Glu Val Glu Ala Met Tyr Leu Ser Gly Val Ala Gly 
1               5                   10          


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  45

Val Ala Leu Gly Ile 
1               5   


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  46

Ala Leu Thr Val 
1               


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  47

Ala Val Ile Gly Ile 
1               5   


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  48

Thr Ser Tyr Ile 
1               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 23

<400>  49

Ala Lys Ala Leu Asn Asn Ala Val 
1               5               


<210>  50
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  50

Met Pro Gly Phe Asn Tyr Gly Gly Lys Gly Asp Gly Thr Asn Trp Ser 
1               5                   10                  15      


Ser Glu Arg Gly Thr Gly Pro Glu Pro Gly Gly Gly Ser Arg Gly Asn 
            20                  25                  30          


Gly Gly Asp Arg Asp Asn Ser Arg Gly Gly Ala Gly Asn Arg Gly Asn 
        35                  40                  45              


Trp Ala Gly Ser Gly Pro Leu Ser Ala Ala Leu Ile Asn Asp Ser Ile 
    50                  55                  60                  


Ala Glu Ala Leu Glu Lys Gln Leu Pro Arg Asn Thr Val Glu Ala Thr 
65                  70                  75                  80  


Ser Thr Pro Ala Tyr Lys Lys Met Arg Ala Ala Phe Asp Ala Leu Pro 
                85                  90                  95      


Leu Asp Lys Gln Pro Glu Ala Arg Ala Gln Ile Thr Lys Ala Trp Gln 
            100                 105                 110         


Ser Ala His Asp Ala Met Pro Asp 
        115                 120 


<210>  51
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  51

Thr Thr Thr Thr Glu Asn Val Gly Gly Gly Lys Asn Gly His Asn Val 
1               5                   10                  15      


Thr Arg Ser Thr Pro Asn Trp Leu Lys Glu Lys Met Lys Gly Leu Asn 
            20                  25                  30          


Gln Gln Val Asn Asn Asp Leu Ser Gly Ala Leu Ala Gln His Gln Lys 
        35                  40                  45              


Ala Glu Ala Asp Ala Arg Ala Lys Ala Glu Ala Ala Ala Lys Ala Lys 
    50                  55                  60                  


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  52

Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala 
1               5                   10                  15  


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  53

Ala Lys Ala Lys Ala Glu Ala 
1               5           


<210>  54
<211>  142
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  54

Ala Lys Ala Lys Ala Glu Ala Glu Ala Lys Ala Lys Ala Glu Ala Glu 
1               5                   10                  15      


Ala Lys Ala Lys Ala Glu Ala Asp Ala Val Lys Asp Ala Val Lys Phe 
            20                  25                  30          


Thr Ala Asp Phe Tyr Lys Glu Val Phe Ser Val Tyr Gly Glu Lys Ala 
        35                  40                  45              


Glu Gln Leu Ala Asn Leu Leu Ala Thr Gln Ala Lys Gly Lys Asn Ile 
    50                  55                  60                  


Arg Asn Ile Asp Asp Ala Leu Lys Ala Tyr Glu Lys His Lys Thr Asn 
65                  70                  75                  80  


Ile Asn Lys Lys Ile Asn Ala Gln Asp Arg Ala Ala Ile Ala Lys Ala 
                85                  90                  95      


Leu Glu Ser Val Asp Val Lys Glu Ala Ala Lys Asn Phe Ala Lys Phe 
            100                 105                 110         


Ser Lys Gly Leu Gly Tyr Val Gly Pro Thr Met Asp Val Val Asp Leu 
        115                 120                 125             


Val Leu Glu Leu Arg Lys Ala Ile Lys Glu Asp Asn Trp Arg 
    130                 135                 140         


<210>  55
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  conserved sequence stretch in SEQ ID NO: 24

<400>  55

Phe Phe Val Lys Ile Glu Ala Ile Ala Ile Ser Phe Gly Ala Thr Gln 
1               5                   10                  15      


Leu Ala Ala Leu Ala Phe Ala Ser Leu Leu Gly Ala Pro Val Gly Leu 
            20                  25                  30          


Leu Gly Tyr Ala Leu Ile Met Ala Gly Ile Gly Ala Leu Val Ser Asp 
        35                  40                  45              


Asp Val Val Asp Ala Ala Asn Lys Ile Ile Gly Ile 
    50                  55                  60  


<210>  56
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  khe gene amplification forward primer

<400>  56
gatgaaacga cctgattgca ttc                                               23


<210>  57
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  khe gene amplification reverse primer

<400>  57
ccgggctgtc gggataag                                                     18


<210>  58
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  khe gene amplification probe sequence

<400>  58
cgcgaactgg aagggcccg                                                    19


