                         SEQUENCE LISTING

<110>  Deutsches Zentrum fr Neurodegenerative Erkrankungen e.V. 
       (DZNE)
       Max-Delbrck-Centrum fr Molekulare Medizin in der 
       Helmholtz-Gemeinschaft
 
<120>  CHIMERIC AUTOANTIBODY RECEPTOR (CAAR) THAT BINDS AUTOANTIBODIES 
       TARGETING THE CENTRAL NERVOUS SYSTEM IN NEUROLOGICAL AUTOIMMUNE 
       DISEASE

<130>  XII 2113/19WO

<150>  EP19178541.9
<151>  2019-06-05

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component sequence

<400>  1
atggctctgc ctgtgacagc tctgctgctg cctctggccc tgctgctgca tgctgccaga       60

cct                                                                     63


<210>  2
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  2
atgtctacaa tgagactgct gacactggcc ctgctgttca gctgttctgt ggcc             54


<210>  3
<211>  1125
<212>  DNA
<213>  Homo sapiens

<400>  3
agagccgcct gcgatcccaa gatcgtgaat atcggagccg tgctgagcac ccggaagcac       60

gagcagatgt tcagagaagc cgtgaaccag gccaacaaga gacacggcag ctggaagatc      120

cagctgaacg ccacaagcgt gacccacaag cctaacgcca ttcagatggc cctgagcgtg      180

tgcgaggatc tgatcagctc tcaggtgtac gccatcctgg tgtctcaccc tccaacacct      240

aacgaccact tcacccctac acctgtgtct tacaccgccg gcttctacag aatccctgtg      300

ctgggcctga ccaccagaat gagcatctac agcgacaaga gcatccacct gagctttctg      360

cggaccgtgc ctccttacag ccaccagtct agcgtttggt tcgagatgat gcgggtgtac      420

agctggaacc acatcatcct gctggtgtcc gacgaccacg aaggcagagc cgctcagaag      480

agactggaaa ccctgctgga agagagagag tccaaggccg agaaggtgct gcagttcgat      540

cccggcacca agaacgtgac agccctgctg atggaagcca aagaactgga agccagagtg      600

atcatcctga gcgcctccga agatgatgcc gccaccgtgt atagagccgc cgctatgctg      660

aatatgaccg gcagcggata cgtgtggctc gtgggcgaga gagagattag cggaaacgcc      720

ctgagatacg cccctgatgg aatcctggga ctgcagctga tcaacggcaa gaacgagagc      780

gcccacatct ctgatgccgt gggagttgtg gctcaggccg tgcatgagct gctggaaaaa      840

gagaacatca ccgatcctcc acggggctgc gtgggcaaca ccaacatctg gaaaacaggc      900

ccactgttca agcgggtgct gatgagcagc aaatacgccg atggcgtgac aggccgggtc      960

gagtttaatg aggacggcga cagaaagttc gccaactaca gcatcatgaa cctgcagaac     1020

cggaagctgg tgcaagtggg catctacaac ggcacccacg tgatccccaa cgaccggaag     1080

attatctggc ctggcggcga aaccgagaag cccagaggct accag                     1125


<210>  4
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  4
atgagcacca gactgaagat tgtgaccatc caccaagagc ctttcgtgta cgtgaagccc       60

acactgagcg acggcacctg taaagaagag ttcaccgtca acggcgaccc tgtgaagaaa      120

gtgatctgca caggccccaa cgatacaagc cctggcagcc ctagacacac cgttcctcag      180

tgctgctacg gcttctgcat cgacctgctg atcaagctgg cccggaccat gaacttcacc      240

tacgaagtgc acctggtggc cgacggcaag tttggcacac aagagagagt gaacaacagc      300

aacaagaaag aatggaacgg catgatgggc gagctgctgt ctggacaggc cgacatgatt      360

gtggcccctc tgaccatcaa caacgagcgg gcccagtaca tcgagttcag caagccattc      420

aagtaccagg gcctgacaat cctggtcaag aaa                                   453


<210>  5
<211>  414
<212>  DNA
<213>  Homo sapiens

<400>  5
cggatcaccg gcatcaacga ccccagactg agaaatccct ccgacaagtt catctacgcc       60

acagtgaagc agagcagcgt ggacatctac ttcagacgcc aggtggaact gagcaccatg      120

tacagacaca tggaaaagca caactacgag tctgccgccg aggcaatcca ggccgtcaga      180

gataacaagc tgcacgcctt catctgggac agcgccgtgc tggaatttga ggccagccag      240

aagtgcgatc tggtcaccac cggtgaactg tttttcagaa gcggctttgg catcggcatg      300

cggaaggact ctccctggaa gcagaatgtg tccctgagca tcctgaagtc tcacgagaac      360

ggcttcatgg aagatctgga caagacctgg gtccgatacc aagagtgcga tagc            414


<210>  6
<211>  3245
<212>  DNA
<213>  Homo sapiens

<400>  6
gcccgcggcc cgagcccatg agcaccatgc gcctgctgac gctcgccctg ctgttctcct       60

gctccgtcgc ccgtgccgcg tgcgacccca agatcgtcaa cattggcgcg gtgctgagca      120

cgcggaagca cgagcagatg ttccgcgagg ccgtgaacca ggccaacaag cggcacggct      180

cctggaagat tcagctcaat gccacctccg tcacgcacaa gcccaacgcc atccagatgg      240

ctctgtcggt gtgcgaggac ctcatctcca gccaggtcta cgccatccta gttagccatc      300

cacctacccc caacgaccac ttcactccca cccctgtctc ctacacagcc ggcttctacc      360

gcatacccgt gctggggctg accacccgca tgtccatcta ctcggacaag agcatccacc      420

tgagcttcct gcgcaccgtg ccgccctact cccaccagtc cagcgtgtgg tttgagatga      480

tgcgtgtcta cagctggaac cacatcatcc tgctggtcag cgacgaccac gagggccggg      540

cggctcagaa acgcctggag acgctgctgg aggagcgtga gtccaaggca gagaaggtgc      600

tgcagtttga cccagggacc aagaacgtga cggccctgct gatggaggcg aaagagctgg      660

aggcccgggt catcatcctt tctgccagcg aggacgatgc tgccactgta taccgcgcag      720

ccgcgatgct gaacatgacg ggctccgggt acgtgtggct ggtcggcgag cgcgagatct      780

cggggaacgc cctgcgctac gccccggacg gcatcctcgg gctgcagctc atcaacggca      840

agaacgagtc ggcccacatc agcgacgccg taggcgtggt ggcccaggcc gtgcacgagc      900

tcctcgagaa ggagaacatc accgacccgc cgcggggctg cgtgggcaac accaacatct      960

ggaagaccgg gccgctcttc aagagagtgc tgatgtcttc caagtatgcg gatggggtga     1020

ctggtcgcgt ggagttcaat gaggatgggg accggaagtt cgccaactac agcatcatga     1080

acctgcagaa ccgcaagctg gtgcaagtgg gcatctacaa tggcacccac gtcatcccta     1140

atgacaggaa gatcatctgg ccaggcggag agacagagaa gcctcgaggg taccagatgt     1200

ccaccagact gaagattgtg acgatccacc aggagccctt cgtgtacgtc aagcccacgc     1260

tgagtgatgg gacatgcaag gaggagttca cagtcaacgg cgacccagtc aagaaggtga     1320

tctgcaccgg gcccaacgac acgtcgccgg gcagcccccg ccacacggtg cctcagtgtt     1380

gctacggctt ttgcatcgac ctgctcatca agctggcacg gaccatgaac ttcacctacg     1440

aggtgcacct ggtggcagat ggcaagttcg gcacacagga gcgggtgaac aacagcaaca     1500

agaaggagtg gaatgggatg atgggcgagc tgctcagcgg gcaggcagac atgatcgtgg     1560

cgccgctaac cataaacaac gagcgcgcgc agtacatcga gttttccaag cccttcaagt     1620

accagggcct gactattctg gtcaagaagg agattccccg gagcacgctg gactcgttca     1680

tgcagccgtt ccagagcaca ctgtggctgc tggtggggct gtcggtgcac gtggtggccg     1740

tgatgctgta cctgctggac cgcttcagcc ccttcggccg gttcaaggtg aacagcgagg     1800

aggaggagga ggacgcactg accctgtcct cggccatgtg gttctcctgg ggcgtcctgc     1860

tcaactccgg catcggggaa ggcgccccca gaagcttctc agcgcgcatc ctgggcatgg     1920

tgtgggccgg ctttgccatg atcatcgtgg cctcctacac cgccaacctg gcggccttcc     1980

tggtgctgga ccggccggag gagcgcatca cgggcatcaa cgaccctcgg ctgaggaacc     2040

cctcggacaa gtttatctac gccacggtga agcagagctc cgtggatatc tacttccggc     2100

gccaggtgga gctgagcacc atgtaccggc atatggagaa gcacaactac gagagtgcgg     2160

cggaggccat ccaggccgtg agagacaaca agctgcatgc cttcatctgg gactcggcgg     2220

tgctggagtt cgaggcctcg cagaagtgcg acctggtgac gactggagag ctgtttttcc     2280

gctcgggctt cggcataggc atgcgcaaag acagcccctg gaagcagaac gtctccctgt     2340

ccatcctcaa gtcccacgag aatggcttca tggaagacct ggacaagacg tgggttcggt     2400

atcaggaatg tgactcgcgc agcaacgccc ctgcgaccct tacttttgag aacatggccg     2460

gggtcttcat gctggtagct gggggcatcg tggccgggat cttcctgatt ttcatcgaga     2520

ttgcctacaa gcggcacaag gatgctcgcc ggaagcagat gcagctggcc tttgccgccg     2580

ttaacgtgtg gcggaagaac ctgcagcagt accatcccac tgatatcacg ggcccgctca     2640

acctctcaga tccctcggtc agcaccgtgg tgtgaggccc ccggaggcgc ccacctgccc     2700

agttagcccg gccaaggaca ctgatgggtc ctgctgctcg ggaaggcctg agggaagccc     2760

acccgcccca gagactgccc accctgggcc tcccgtccgt ccgcccgccc accccgctgc     2820

ctggcgggca gcccctgctg gaccaaggtg cggaccggag cggctgagga cggggcagag     2880

ctgagtcggc tgggcagggc cgcagggcgc tccggcagag gcagggccct ggggtctctg     2940

agcagtgggg agcgggggct aactggcccc aggcggaggg gcttggagca gagacggcag     3000

ccccatcctt cccgcagcac cagcctgagc cacagtgggg cccatggccc cagctggctg     3060

ggtcgcccct cctcgggcgc ctgcgctcct ctgcagcctg agctccaccc tcccctcttc     3120

ttgcggcacc gcccacccac accccgtctg ccccttgacc ccacacgccg gggctggccc     3180

tgccctcccc cacggccgtc cctgacttcc cagctgcagc gcctcccgcc gcctcgggcc     3240

gcctc                                                                 3245


<210>  7
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  7
gcgtcgaccg gcggaggatc tggcggaggc ggatcttctg gc                          42


<210>  8
<211>  72
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  8
atctatatct gggctcctct ggccggcaca tgcggagttc tgctgctgag cctggtcatc       60

accctgtact gc                                                           72


<210>  9
<211>  177
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  9
ttctggctgc ctattggctg cgccgccttt gtggtcgtgt gtatcctggg ctgcatcctg       60

atctgctggc tgaccaagaa aaagtacagc agcagcgtgc acgaccccaa cggcgagtac      120

atgttcatga gagccgtgaa caccgccaag aagtccagac tgaccgacgt gacactg         177


<210>  10
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  10
aagcggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag       60

acaacccaag aggaagatgg ctgctcctgc agattccctg aggaagagga aggcggctgc      120

gagctg                                                                 126


<210>  11
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  11
agagtgaagt tctccagatc cgccgacgct cctgcttacc agcagggaca gaaccagctg       60

tataacgagc tgaacctggg gcgcagagaa gagtacgacg tgctggacaa gcggagaggc      120

agagatcctg agatgggcgg caagcccaga cggaagaatc ctcaagaggg cctgtacaac      180

gaactccaga aagacaagat ggccgaggcc tacagcgaga tcggaatgaa gggcgagcgc      240

agaagaggca agggacacga tggactgtat cagggcctgt ctaccgccac caaggacacc      300

tatgatgccc tgcacatgca ggccctgcca cctagataa                             339


<210>  12
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  12

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  13
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  13

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala 
        


<210>  14
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val Leu Ser 
1               5                   10                  15      


Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln Ala Asn 
            20                  25                  30          


Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser Val Thr 
        35                  40                  45              


His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu Asp Leu 
    50                  55                  60                  


Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro Thr Pro 
65                  70                  75                  80  


Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly Phe Tyr 
                85                  90                  95      


Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr Ser Asp 
            100                 105                 110         


Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr Ser His 
        115                 120                 125             


Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp Asn His 
    130                 135                 140                 


Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala Gln Lys 
145                 150                 155                 160 


Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu Lys Val 
                165                 170                 175     


Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu Met Glu 
            180                 185                 190         


Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser Glu Asp 
        195                 200                 205             


Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met Thr Gly 
    210                 215                 220                 


Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly Asn Ala 
225                 230                 235                 240 


Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile Asn Gly 
                245                 250                 255     


Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val Ala Gln 
            260                 265                 270         


Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro Pro Arg 
        275                 280                 285             


Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu Phe Lys 
    290                 295                 300                 


Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly Arg Val 
305                 310                 315                 320 


Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser Ile Met 
                325                 330                 335     


Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn Gly Thr 
            340                 345                 350         


His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly Glu Thr 
        355                 360                 365             


Glu Lys Pro Arg Gly Tyr Gln 
    370                 375 


<210>  15
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Thr Arg Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val 
1               5                   10                  15      


Tyr Val Lys Pro Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr 
            20                  25                  30          


Val Asn Gly Asp Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp 
        35                  40                  45              


Thr Ser Pro Gly Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly 
    50                  55                  60                  


Phe Cys Ile Asp Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr 
65                  70                  75                  80  


Tyr Glu Val His Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg 
                85                  90                  95      


Val Asn Asn Ser Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu 
            100                 105                 110         


Leu Ser Gly Gln Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn 
        115                 120                 125             


Glu Arg Ala Gln Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly 
    130                 135                 140                 


Leu Thr Ile Leu Val Lys Lys 
145                 150     


<210>  16
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  16

Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg Asn Pro Ser Asp Lys 
1               5                   10                  15      


Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val Asp Ile Tyr Phe Arg 
            20                  25                  30          


Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His Met Glu Lys His Asn 
        35                  40                  45              


Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val Arg Asp Asn Lys Leu 
    50                  55                  60                  


His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu Phe Glu Ala Ser Gln 
65                  70                  75                  80  


Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe Phe Arg Ser Gly Phe 
                85                  90                  95      


Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys Gln Asn Val Ser Leu 
            100                 105                 110         


Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met Glu Asp Leu Asp Lys 
        115                 120                 125             


Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
    130                 135             


<210>  17
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Thr Met Arg Leu Leu Thr Leu Ala Leu Leu Phe Ser Cys Ser 
1               5                   10                  15      


Val Ala Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile Gly Ala Val 
            20                  25                  30          


Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala Val Asn Gln 
        35                  40                  45              


Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn Ala Thr Ser 
    50                  55                  60                  


Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser Val Cys Glu 
65                  70                  75                  80  


Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser His Pro Pro 
                85                  90                  95      


Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr Thr Ala Gly 
            100                 105                 110         


Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met Ser Ile Tyr 
        115                 120                 125             


Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val Pro Pro Tyr 
    130                 135                 140                 


Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val Tyr Ser Trp 
145                 150                 155                 160 


Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly Arg Ala Ala 
                165                 170                 175     


Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser Lys Ala Glu 
            180                 185                 190         


Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr Ala Leu Leu 
        195                 200                 205             


Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu Ser Ala Ser 
    210                 215                 220                 


Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met Leu Asn Met 
225                 230                 235                 240 


Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu Ile Ser Gly 
                245                 250                 255     


Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu Gln Leu Ile 
            260                 265                 270         


Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val Gly Val Val 
        275                 280                 285             


Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile Thr Asp Pro 
    290                 295                 300                 


Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr Gly Pro Leu 
305                 310                 315                 320 


Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly Val Thr Gly 
                325                 330                 335     


Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala Asn Tyr Ser 
            340                 345                 350         


Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly Ile Tyr Asn 
        355                 360                 365             


Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp Pro Gly Gly 
    370                 375                 380                 


Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg Leu Lys Ile 
385                 390                 395                 400 


Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro Thr Leu Ser 
                405                 410                 415     


Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp Pro Val Lys 
            420                 425                 430         


Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly Ser Pro Arg 
        435                 440                 445             


His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp Leu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His Leu Val Ala 
465                 470                 475                 480 


Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser Asn Lys Lys 
                485                 490                 495     


Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln Ala Asp Met 
            500                 505                 510         


Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln Tyr Ile Glu 
        515                 520                 525             


Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu Val Lys Lys 
    530                 535                 540                 


Glu Ile Pro Arg Ser Thr Leu Asp Ser Phe Met Gln Pro Phe Gln Ser 
545                 550                 555                 560 


Thr Leu Trp Leu Leu Val Gly Leu Ser Val His Val Val Ala Val Met 
                565                 570                 575     


Leu Tyr Leu Leu Asp Arg Phe Ser Pro Phe Gly Arg Phe Lys Val Asn 
            580                 585                 590         


Ser Glu Glu Glu Glu Glu Asp Ala Leu Thr Leu Ser Ser Ala Met Trp 
        595                 600                 605             


Phe Ser Trp Gly Val Leu Leu Asn Ser Gly Ile Gly Glu Gly Ala Pro 
    610                 615                 620                 


Arg Ser Phe Ser Ala Arg Ile Leu Gly Met Val Trp Ala Gly Phe Ala 
625                 630                 635                 640 


Met Ile Ile Val Ala Ser Tyr Thr Ala Asn Leu Ala Ala Phe Leu Val 
                645                 650                 655     


Leu Asp Arg Pro Glu Glu Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu 
            660                 665                 670         


Arg Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser 
        675                 680                 685             


Val Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg 
    690                 695                 700                 


His Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala 
705                 710                 715                 720 


Val Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu 
                725                 730                 735     


Glu Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu 
            740                 745                 750         


Phe Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp 
        755                 760                 765             


Lys Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe 
    770                 775                 780                 


Met Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser 
785                 790                 795                 800 


Arg Ser Asn Ala Pro Ala Thr Leu Thr Phe Glu Asn Met Ala Gly Val 
                805                 810                 815     


Phe Met Leu Val Ala Gly Gly Ile Val Ala Gly Ile Phe Leu Ile Phe 
            820                 825                 830         


Ile Glu Ile Ala Tyr Lys Arg His Lys Asp Ala Arg Arg Lys Gln Met 
        835                 840                 845             


Gln Leu Ala Phe Ala Ala Val Asn Val Trp Arg Lys Asn Leu Gln Gln 
    850                 855                 860                 


Tyr His Pro Thr Asp Ile Thr Gly Pro Leu Asn Leu Ser Asp Pro Ser 
865                 870                 875                 880 


Val Ser Thr Val Val 
                885 


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  18

Ala Ser Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  19

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly 
1               5                   10                  


<210>  20
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  20

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  21
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  21

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser 
            20                  25                  30          


Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr 
        35                  40                  45              


Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
    50                  55                  


<210>  22
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  22

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  23

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  24
<211>  2640
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  24
atggctctgc ctgtgacagc tctgctgctg cctctggccc tgctgctgca tgctgccaga       60

cctagagccg cctgcgatcc caagatcgtg aatatcggag ccgtgctgag cacccggaag      120

cacgagcaga tgttcagaga agccgtgaac caggccaaca agagacacgg cagctggaag      180

atccagctga acgccacaag cgtgacccac aagcctaacg ccattcagat ggccctgagc      240

gtgtgcgagg atctgatcag ctctcaggtg tacgccatcc tggtgtctca ccctccaaca      300

cctaacgacc acttcacccc tacacctgtg tcttacaccg ccggcttcta cagaatccct      360

gtgctgggcc tgaccaccag aatgagcatc tacagcgaca agagcatcca cctgagcttt      420

ctgcggaccg tgcctcctta cagccaccag tctagcgttt ggttcgagat gatgcgggtg      480

tacagctgga accacatcat cctgctggtg tccgacgacc acgaaggcag agccgctcag      540

aagagactgg aaaccctgct ggaagagaga gagtccaagg ccgagaaggt gctgcagttc      600

gatcccggca ccaagaacgt gacagccctg ctgatggaag ccaaagaact ggaagccaga      660

gtgatcatcc tgagcgcctc cgaagatgat gccgccaccg tgtatagagc cgccgctatg      720

ctgaatatga ccggcagcgg atacgtgtgg ctcgtgggcg agagagagat tagcggaaac      780

gccctgagat acgcccctga tggaatcctg ggactgcagc tgatcaacgg caagaacgag      840

agcgcccaca tctctgatgc cgtgggagtt gtggctcagg ccgtgcatga gctgctggaa      900

aaagagaaca tcaccgatcc tccacggggc tgcgtgggca acaccaacat ctggaaaaca      960

ggcccactgt tcaagcgggt gctgatgagc agcaaatacg ccgatggcgt gacaggccgg     1020

gtcgagttta atgaggacgg cgacagaaag ttcgccaact acagcatcat gaacctgcag     1080

aaccggaagc tggtgcaagt gggcatctac aacggcaccc acgtgatccc caacgaccgg     1140

aagattatct ggcctggcgg cgaaaccgag aagcccagag gctaccagat gagcaccaga     1200

ctgaagattg tgaccatcca ccaagagcct ttcgtgtacg tgaagcccac actgagcgac     1260

ggcacctgta aagaagagtt caccgtcaac ggcgaccctg tgaagaaagt gatctgcaca     1320

ggccccaacg atacaagccc tggcagccct agacacaccg ttcctcagtg ctgctacggc     1380

ttctgcatcg acctgctgat caagctggcc cggaccatga acttcaccta cgaagtgcac     1440

ctggtggccg acggcaagtt tggcacacaa gagagagtga acaacagcaa caagaaagaa     1500

tggaacggca tgatgggcga gctgctgtct ggacaggccg acatgattgt ggcccctctg     1560

accatcaaca acgagcgggc ccagtacatc gagttcagca agccattcaa gtaccagggc     1620

ctgacaatcc tggtcaagaa aggcacccgg atcaccggca tcaacgaccc cagactgaga     1680

aatccctccg acaagttcat ctacgccaca gtgaagcaga gcagcgtgga catctacttc     1740

agacgccagg tggaactgag caccatgtac agacacatgg aaaagcacaa ctacgagtct     1800

gccgccgagg caatccaggc cgtcagagat aacaagctgc acgccttcat ctgggacagc     1860

gccgtgctgg aatttgaggc cagccagaag tgcgatctgg tcaccaccgg tgaactgttt     1920

ttcagaagcg gctttggcat cggcatgcgg aaggactctc cctggaagca gaatgtgtcc     1980

ctgagcatcc tgaagtctca cgagaacggc ttcatggaag atctggacaa gacctgggtc     2040

cgataccaag agtgcgatag cgcgtcgacc ggcggaggat ctggcggagg cggatcttct     2100

ggcatctata tctgggctcc tctggccggc acatgcggag ttctgctgct gagcctggtc     2160

atcaccctgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     2220

atgcggcccg tgcagacaac ccaagaggaa gatggctgct cctgcagatt ccctgaggaa     2280

gaggaaggcg gctgcgagct gagagtgaag ttctccagat ccgccgacgc tcctgcttac     2340

cagcagggac agaaccagct gtataacgag ctgaacctgg ggcgcagaga agagtacgac     2400

gtgctggaca agcggagagg cagagatcct gagatgggcg gcaagcccag acggaagaat     2460

cctcaagagg gcctgtacaa cgaactccag aaagacaaga tggccgaggc ctacagcgag     2520

atcggaatga agggcgagcg cagaagaggc aagggacacg atggactgta tcagggcctg     2580

tctaccgcca ccaaggacac ctatgatgcc ctgcacatgc aggccctgcc acctagataa     2640


<210>  25
<211>  2220
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  25
atggctctgc ctgtgacagc tctgctgctg cctctggccc tgctgctgca tgctgccaga       60

cctagagccg cctgcgatcc caagatcgtg aatatcggag ccgtgctgag cacccggaag      120

cacgagcaga tgttcagaga agccgtgaac caggccaaca agagacacgg cagctggaag      180

atccagctga acgccacaag cgtgacccac aagcctaacg ccattcagat ggccctgagc      240

gtgtgcgagg atctgatcag ctctcaggtg tacgccatcc tggtgtctca ccctccaaca      300

cctaacgacc acttcacccc tacacctgtg tcttacaccg ccggcttcta cagaatccct      360

gtgctgggcc tgaccaccag aatgagcatc tacagcgaca agagcatcca cctgagcttt      420

ctgcggaccg tgcctcctta cagccaccag tctagcgttt ggttcgagat gatgcgggtg      480

tacagctgga accacatcat cctgctggtg tccgacgacc acgaaggcag agccgctcag      540

aagagactgg aaaccctgct ggaagagaga gagtccaagg ccgagaaggt gctgcagttc      600

gatcccggca ccaagaacgt gacagccctg ctgatggaag ccaaagaact ggaagccaga      660

gtgatcatcc tgagcgcctc cgaagatgat gccgccaccg tgtatagagc cgccgctatg      720

ctgaatatga ccggcagcgg atacgtgtgg ctcgtgggcg agagagagat tagcggaaac      780

gccctgagat acgcccctga tggaatcctg ggactgcagc tgatcaacgg caagaacgag      840

agcgcccaca tctctgatgc cgtgggagtt gtggctcagg ccgtgcatga gctgctggaa      900

aaagagaaca tcaccgatcc tccacggggc tgcgtgggca acaccaacat ctggaaaaca      960

ggcccactgt tcaagcgggt gctgatgagc agcaaatacg ccgatggcgt gacaggccgg     1020

gtcgagttta atgaggacgg cgacagaaag ttcgccaact acagcatcat gaacctgcag     1080

aaccggaagc tggtgcaagt gggcatctac aacggcaccc acgtgatccc caacgaccgg     1140

aagattatct ggcctggcgg cgaaaccgag aagcccagag gctaccagat gagcaccaga     1200

ctgaagattg tgaccatcca ccaagagcct ttcgtgtacg tgaagcccac actgagcgac     1260

ggcacctgta aagaagagtt caccgtcaac ggcgaccctg tgaagaaagt gatctgcaca     1320

ggccccaacg atacaagccc tggcagccct agacacaccg ttcctcagtg ctgctacggc     1380

ttctgcatcg acctgctgat caagctggcc cggaccatga acttcaccta cgaagtgcac     1440

ctggtggccg acggcaagtt tggcacacaa gagagagtga acaacagcaa caagaaagaa     1500

tggaacggca tgatgggcga gctgctgtct ggacaggccg acatgattgt ggcccctctg     1560

accatcaaca acgagcgggc ccagtacatc gagttcagca agccattcaa gtaccagggc     1620

ctgacaatcc tggtcaagaa agcgtcgacc ggcggaggat ctggcggagg cggatcttct     1680

ggcatctata tctgggctcc tctggccggc acatgcggag ttctgctgct gagcctggtc     1740

atcaccctgt actgcaagcg gggcagaaag aagctgctgt acatcttcaa gcagcccttc     1800

atgcggcccg tgcagacaac ccaagaggaa gatggctgct cctgcagatt ccctgaggaa     1860

gaggaaggcg gctgcgagct gagagtgaag ttctccagat ccgccgacgc tcctgcttac     1920

cagcagggac agaaccagct gtataacgag ctgaacctgg ggcgcagaga agagtacgac     1980

gtgctggaca agcggagagg cagagatcct gagatgggcg gcaagcccag acggaagaat     2040

cctcaagagg gcctgtacaa cgaactccag aaagacaaga tggccgaggc ctacagcgag     2100

atcggaatga agggcgagcg cagaagaggc aagggacacg atggactgta tcagggcctg     2160

tctaccgcca ccaaggacac ctatgatgcc ctgcacatgc aggccctgcc acctagataa     2220


<210>  26
<211>  1767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  26
atggctctgc ctgtgacagc tctgctgctg cctctggccc tgctgctgca tgctgccaga       60

cctagagccg cctgcgatcc caagatcgtg aatatcggag ccgtgctgag cacccggaag      120

cacgagcaga tgttcagaga agccgtgaac caggccaaca agagacacgg cagctggaag      180

atccagctga acgccacaag cgtgacccac aagcctaacg ccattcagat ggccctgagc      240

gtgtgcgagg atctgatcag ctctcaggtg tacgccatcc tggtgtctca ccctccaaca      300

cctaacgacc acttcacccc tacacctgtg tcttacaccg ccggcttcta cagaatccct      360

gtgctgggcc tgaccaccag aatgagcatc tacagcgaca agagcatcca cctgagcttt      420

ctgcggaccg tgcctcctta cagccaccag tctagcgttt ggttcgagat gatgcgggtg      480

tacagctgga accacatcat cctgctggtg tccgacgacc acgaaggcag agccgctcag      540

aagagactgg aaaccctgct ggaagagaga gagtccaagg ccgagaaggt gctgcagttc      600

gatcccggca ccaagaacgt gacagccctg ctgatggaag ccaaagaact ggaagccaga      660

gtgatcatcc tgagcgcctc cgaagatgat gccgccaccg tgtatagagc cgccgctatg      720

ctgaatatga ccggcagcgg atacgtgtgg ctcgtgggcg agagagagat tagcggaaac      780

gccctgagat acgcccctga tggaatcctg ggactgcagc tgatcaacgg caagaacgag      840

agcgcccaca tctctgatgc cgtgggagtt gtggctcagg ccgtgcatga gctgctggaa      900

aaagagaaca tcaccgatcc tccacggggc tgcgtgggca acaccaacat ctggaaaaca      960

ggcccactgt tcaagcgggt gctgatgagc agcaaatacg ccgatggcgt gacaggccgg     1020

gtcgagttta atgaggacgg cgacagaaag ttcgccaact acagcatcat gaacctgcag     1080

aaccggaagc tggtgcaagt gggcatctac aacggcaccc acgtgatccc caacgaccgg     1140

aagattatct ggcctggcgg cgaaaccgag aagcccagag gctaccaggc gtcgaccggc     1200

ggaggatctg gcggaggcgg atcttctggc atctatatct gggctcctct ggccggcaca     1260

tgcggagttc tgctgctgag cctggtcatc accctgtact gcaagcgggg cagaaagaag     1320

ctgctgtaca tcttcaagca gcccttcatg cggcccgtgc agacaaccca agaggaagat     1380

ggctgctcct gcagattccc tgaggaagag gaaggcggct gcgagctgag agtgaagttc     1440

tccagatccg ccgacgctcc tgcttaccag cagggacaga accagctgta taacgagctg     1500

aacctggggc gcagagaaga gtacgacgtg ctggacaagc ggagaggcag agatcctgag     1560

atgggcggca agcccagacg gaagaatcct caagagggcc tgtacaacga actccagaaa     1620

gacaagatgg ccgaggccta cagcgagatc ggaatgaagg gcgagcgcag aagaggcaag     1680

ggacacgatg gactgtatca gggcctgtct accgccacca aggacaccta tgatgccctg     1740

cacatgcagg ccctgccacc tagataa                                         1767


<210>  27
<211>  1878
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  27
atggctctgc ctgtgacagc tctgctgctg cctctggccc tgctgctgca tgctgccaga       60

cctagagccg cctgcgatcc caagatcgtg aatatcggag ccgtgctgag cacccggaag      120

cacgagcaga tgttcagaga agccgtgaac caggccaaca agagacacgg cagctggaag      180

atccagctga acgccacaag cgtgacccac aagcctaacg ccattcagat ggccctgagc      240

gtgtgcgagg atctgatcag ctctcaggtg tacgccatcc tggtgtctca ccctccaaca      300

cctaacgacc acttcacccc tacacctgtg tcttacaccg ccggcttcta cagaatccct      360

gtgctgggcc tgaccaccag aatgagcatc tacagcgaca agagcatcca cctgagcttt      420

ctgcggaccg tgcctcctta cagccaccag tctagcgttt ggttcgagat gatgcgggtg      480

tacagctgga accacatcat cctgctggtg tccgacgacc acgaaggcag agccgctcag      540

aagagactgg aaaccctgct ggaagagaga gagtccaagg ccgagaaggt gctgcagttc      600

gatcccggca ccaagaacgt gacagccctg ctgatggaag ccaaagaact ggaagccaga      660

gtgatcatcc tgagcgcctc cgaagatgat gccgccaccg tgtatagagc cgccgctatg      720

ctgaatatga ccggcagcgg atacgtgtgg ctcgtgggcg agagagagat tagcggaaac      780

gccctgagat acgcccctga tggaatcctg ggactgcagc tgatcaacgg caagaacgag      840

agcgcccaca tctctgatgc cgtgggagtt gtggctcagg ccgtgcatga gctgctggaa      900

aaagagaaca tcaccgatcc tccacggggc tgcgtgggca acaccaacat ctggaaaaca      960

ggcccactgt tcaagcgggt gctgatgagc agcaaatacg ccgatggcgt gacaggccgg     1020

gtcgagttta atgaggacgg cgacagaaag ttcgccaact acagcatcat gaacctgcag     1080

aaccggaagc tggtgcaagt gggcatctac aacggcaccc acgtgatccc caacgaccgg     1140

aagattatct ggcctggcgg cgaaaccgag aagcccagag gctaccaggc tagcggcgga     1200

ggcggatctg gtggcggagg atcttctgga ttctggctgc ctattggctg cgccgccttt     1260

gtggtcgtgt gtatcctggg ctgcatcctg atctgctggc tgaccaagaa aaagtacagc     1320

agcagcgtgc acgaccccaa cggcgagtac atgttcatga gagccgtgaa caccgccaag     1380

aagtccagac tgaccgacgt gacactgggc agcaagcggg gaagaaagaa gctgctgtat     1440

atcttcaagc agcccttcat gcggcccgtg cagaccacac aagaggaaga tggctgctcc     1500

tgcagattcc ccgaggaaga agaaggcggc tgcgagctga gagtgaagtt cagcagatcc     1560

gctgacgccc ctgcctatca gcagggacag aaccagctgt acaacgagct gaacctgggg     1620

agaagagaag agtacgacgt gctggacaag cggagaggca gagatcctga gatgggcggc     1680

aagcccagac ggaagaatcc tcaagagggc ctgtataatg agctgcagaa agacaagatg     1740

gccgaggcct acagcgagat cggaatgaag ggcgagcgca gaagaggcaa gggacacgat     1800

ggactgtacc agggcctgag caccgccacc aaggatacct atgatgccct gcacatgcag     1860

gccctgcctc caagataa                                                   1878


<210>  28
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile 
            20                  25                  30          


Gly Ala Val Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala 
        35                  40                  45              


Val Asn Gln Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn 
    50                  55                  60                  


Ala Thr Ser Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser 
65                  70                  75                  80  


Val Cys Glu Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser 
                85                  90                  95      


His Pro Pro Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr 
            100                 105                 110         


Thr Ala Gly Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met 
        115                 120                 125             


Ser Ile Tyr Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val 
    130                 135                 140                 


Pro Pro Tyr Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val 
145                 150                 155                 160 


Tyr Ser Trp Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly 
                165                 170                 175     


Arg Ala Ala Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser 
            180                 185                 190         


Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr 
        195                 200                 205             


Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu 
    210                 215                 220                 


Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met 
225                 230                 235                 240 


Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu 
                245                 250                 255     


Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu 
            260                 265                 270         


Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val 
        275                 280                 285             


Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile 
    290                 295                 300                 


Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr 
305                 310                 315                 320 


Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly 
                325                 330                 335     


Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala 
            340                 345                 350         


Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly 
        355                 360                 365             


Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp 
    370                 375                 380                 


Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg 
385                 390                 395                 400 


Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro 
                405                 410                 415     


Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp 
            420                 425                 430         


Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly 
        435                 440                 445             


Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp 
    450                 455                 460                 


Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His 
465                 470                 475                 480 


Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser 
                485                 490                 495     


Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln 
            500                 505                 510         


Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln 
        515                 520                 525             


Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu 
    530                 535                 540                 


Val Lys Lys Gly Thr Arg Ile Thr Gly Ile Asn Asp Pro Arg Leu Arg 
545                 550                 555                 560 


Asn Pro Ser Asp Lys Phe Ile Tyr Ala Thr Val Lys Gln Ser Ser Val 
                565                 570                 575     


Asp Ile Tyr Phe Arg Arg Gln Val Glu Leu Ser Thr Met Tyr Arg His 
            580                 585                 590         


Met Glu Lys His Asn Tyr Glu Ser Ala Ala Glu Ala Ile Gln Ala Val 
        595                 600                 605             


Arg Asp Asn Lys Leu His Ala Phe Ile Trp Asp Ser Ala Val Leu Glu 
    610                 615                 620                 


Phe Glu Ala Ser Gln Lys Cys Asp Leu Val Thr Thr Gly Glu Leu Phe 
625                 630                 635                 640 


Phe Arg Ser Gly Phe Gly Ile Gly Met Arg Lys Asp Ser Pro Trp Lys 
                645                 650                 655     


Gln Asn Val Ser Leu Ser Ile Leu Lys Ser His Glu Asn Gly Phe Met 
            660                 665                 670         


Glu Asp Leu Asp Lys Thr Trp Val Arg Tyr Gln Glu Cys Asp Ser Ala 
        675                 680                 685             


Ser Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile 
    690                 695                 700                 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
705                 710                 715                 720 


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
                725                 730                 735     


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            740                 745                 750         


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
        755                 760                 765             


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
    770                 775                 780                 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
785                 790                 795                 800 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
                805                 810                 815     


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
            820                 825                 830         


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
        835                 840                 845             


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
    850                 855                 860                 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
865                 870                 875                 


<210>  29
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile 
            20                  25                  30          


Gly Ala Val Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala 
        35                  40                  45              


Val Asn Gln Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn 
    50                  55                  60                  


Ala Thr Ser Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser 
65                  70                  75                  80  


Val Cys Glu Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser 
                85                  90                  95      


His Pro Pro Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr 
            100                 105                 110         


Thr Ala Gly Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met 
        115                 120                 125             


Ser Ile Tyr Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val 
    130                 135                 140                 


Pro Pro Tyr Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val 
145                 150                 155                 160 


Tyr Ser Trp Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly 
                165                 170                 175     


Arg Ala Ala Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser 
            180                 185                 190         


Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr 
        195                 200                 205             


Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu 
    210                 215                 220                 


Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met 
225                 230                 235                 240 


Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu 
                245                 250                 255     


Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu 
            260                 265                 270         


Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val 
        275                 280                 285             


Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile 
    290                 295                 300                 


Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr 
305                 310                 315                 320 


Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly 
                325                 330                 335     


Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala 
            340                 345                 350         


Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly 
        355                 360                 365             


Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp 
    370                 375                 380                 


Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Met Ser Thr Arg 
385                 390                 395                 400 


Leu Lys Ile Val Thr Ile His Gln Glu Pro Phe Val Tyr Val Lys Pro 
                405                 410                 415     


Thr Leu Ser Asp Gly Thr Cys Lys Glu Glu Phe Thr Val Asn Gly Asp 
            420                 425                 430         


Pro Val Lys Lys Val Ile Cys Thr Gly Pro Asn Asp Thr Ser Pro Gly 
        435                 440                 445             


Ser Pro Arg His Thr Val Pro Gln Cys Cys Tyr Gly Phe Cys Ile Asp 
    450                 455                 460                 


Leu Leu Ile Lys Leu Ala Arg Thr Met Asn Phe Thr Tyr Glu Val His 
465                 470                 475                 480 


Leu Val Ala Asp Gly Lys Phe Gly Thr Gln Glu Arg Val Asn Asn Ser 
                485                 490                 495     


Asn Lys Lys Glu Trp Asn Gly Met Met Gly Glu Leu Leu Ser Gly Gln 
            500                 505                 510         


Ala Asp Met Ile Val Ala Pro Leu Thr Ile Asn Asn Glu Arg Ala Gln 
        515                 520                 525             


Tyr Ile Glu Phe Ser Lys Pro Phe Lys Tyr Gln Gly Leu Thr Ile Leu 
    530                 535                 540                 


Val Lys Lys Ala Ser Thr Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser 
545                 550                 555                 560 


Gly Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                565                 570                 575     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            580                 585                 590         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        595                 600                 605             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    610                 615                 620                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
625                 630                 635                 640 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                645                 650                 655     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            660                 665                 670         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        675                 680                 685             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    690                 695                 700                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
705                 710                 715                 720 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                725                 730                 735     


Pro Pro Arg 
            


<210>  30
<211>  588
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile 
            20                  25                  30          


Gly Ala Val Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala 
        35                  40                  45              


Val Asn Gln Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn 
    50                  55                  60                  


Ala Thr Ser Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser 
65                  70                  75                  80  


Val Cys Glu Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser 
                85                  90                  95      


His Pro Pro Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr 
            100                 105                 110         


Thr Ala Gly Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met 
        115                 120                 125             


Ser Ile Tyr Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val 
    130                 135                 140                 


Pro Pro Tyr Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val 
145                 150                 155                 160 


Tyr Ser Trp Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly 
                165                 170                 175     


Arg Ala Ala Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser 
            180                 185                 190         


Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr 
        195                 200                 205             


Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu 
    210                 215                 220                 


Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met 
225                 230                 235                 240 


Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu 
                245                 250                 255     


Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu 
            260                 265                 270         


Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val 
        275                 280                 285             


Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile 
    290                 295                 300                 


Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr 
305                 310                 315                 320 


Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly 
                325                 330                 335     


Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala 
            340                 345                 350         


Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly 
        355                 360                 365             


Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp 
    370                 375                 380                 


Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Ala Ser Thr Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Ile Tyr Ile Trp Ala Pro 
                405                 410                 415     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            420                 425                 430         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        435                 440                 445             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    450                 455                 460                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
465                 470                 475                 480 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                485                 490                 495     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            500                 505                 510         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        515                 520                 525             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    530                 535                 540                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
545                 550                 555                 560 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                565                 570                 575     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            580                 585             


<210>  31
<211>  625
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAAR construct

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Arg Ala Ala Cys Asp Pro Lys Ile Val Asn Ile 
            20                  25                  30          


Gly Ala Val Leu Ser Thr Arg Lys His Glu Gln Met Phe Arg Glu Ala 
        35                  40                  45              


Val Asn Gln Ala Asn Lys Arg His Gly Ser Trp Lys Ile Gln Leu Asn 
    50                  55                  60                  


Ala Thr Ser Val Thr His Lys Pro Asn Ala Ile Gln Met Ala Leu Ser 
65                  70                  75                  80  


Val Cys Glu Asp Leu Ile Ser Ser Gln Val Tyr Ala Ile Leu Val Ser 
                85                  90                  95      


His Pro Pro Thr Pro Asn Asp His Phe Thr Pro Thr Pro Val Ser Tyr 
            100                 105                 110         


Thr Ala Gly Phe Tyr Arg Ile Pro Val Leu Gly Leu Thr Thr Arg Met 
        115                 120                 125             


Ser Ile Tyr Ser Asp Lys Ser Ile His Leu Ser Phe Leu Arg Thr Val 
    130                 135                 140                 


Pro Pro Tyr Ser His Gln Ser Ser Val Trp Phe Glu Met Met Arg Val 
145                 150                 155                 160 


Tyr Ser Trp Asn His Ile Ile Leu Leu Val Ser Asp Asp His Glu Gly 
                165                 170                 175     


Arg Ala Ala Gln Lys Arg Leu Glu Thr Leu Leu Glu Glu Arg Glu Ser 
            180                 185                 190         


Lys Ala Glu Lys Val Leu Gln Phe Asp Pro Gly Thr Lys Asn Val Thr 
        195                 200                 205             


Ala Leu Leu Met Glu Ala Lys Glu Leu Glu Ala Arg Val Ile Ile Leu 
    210                 215                 220                 


Ser Ala Ser Glu Asp Asp Ala Ala Thr Val Tyr Arg Ala Ala Ala Met 
225                 230                 235                 240 


Leu Asn Met Thr Gly Ser Gly Tyr Val Trp Leu Val Gly Glu Arg Glu 
                245                 250                 255     


Ile Ser Gly Asn Ala Leu Arg Tyr Ala Pro Asp Gly Ile Leu Gly Leu 
            260                 265                 270         


Gln Leu Ile Asn Gly Lys Asn Glu Ser Ala His Ile Ser Asp Ala Val 
        275                 280                 285             


Gly Val Val Ala Gln Ala Val His Glu Leu Leu Glu Lys Glu Asn Ile 
    290                 295                 300                 


Thr Asp Pro Pro Arg Gly Cys Val Gly Asn Thr Asn Ile Trp Lys Thr 
305                 310                 315                 320 


Gly Pro Leu Phe Lys Arg Val Leu Met Ser Ser Lys Tyr Ala Asp Gly 
                325                 330                 335     


Val Thr Gly Arg Val Glu Phe Asn Glu Asp Gly Asp Arg Lys Phe Ala 
            340                 345                 350         


Asn Tyr Ser Ile Met Asn Leu Gln Asn Arg Lys Leu Val Gln Val Gly 
        355                 360                 365             


Ile Tyr Asn Gly Thr His Val Ile Pro Asn Asp Arg Lys Ile Ile Trp 
    370                 375                 380                 


Pro Gly Gly Glu Thr Glu Lys Pro Arg Gly Tyr Gln Ala Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Phe Trp Leu Pro Ile Gly 
                405                 410                 415     


Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys 
            420                 425                 430         


Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly 
        435                 440                 445             


Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu 
    450                 455                 460                 


Thr Asp Val Thr Leu Gly Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
465                 470                 475                 480 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                485                 490                 495     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            500                 505                 510         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        515                 520                 525             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    530                 535                 540                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
545                 550                 555                 560 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                565                 570                 575     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            580                 585                 590         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        595                 600                 605             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    610                 615                 620                 


Arg 
625 


<210>  32
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAAR component

<400>  32
gctagcggcg gaggcggatc tggtggcgga ggatcttctg ga                          42


