                         SEQUENCE LISTING

<110>  UNIVERSITE DE TOURS
       UNIVERSITE DE PICARDIE JULES VERNE
       CENTRE HOSPITALIER UNIVERSITAIRE AMIENS-PICARDIE
 
<120>  NOUVEL ANTICORPS CIBLANT LA PROTEINE VP-1, SES FRAGMENTS ET LEURS
       UTILISATIONS POUR DETECTER L'INFECTION PAR LE POLYOMAVIRUS BK

<130>  WOB 19 AE TOU F6H6

<150>  FR 19/05881
<151>  2019-06-03

<160>  102   

<170>  PatentIn version 3.5

<210>  1
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype Ia

<400>  1
atg gcc cca acc aaa aga aag gga gag tgt cca ggg gca gct ccc aaa         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys           
1               5                   10                  15                

aag cca aag gaa ccc gtg caa gtg cca aaa cta cta ata aaa gga gga         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gta gaa gtt cta gaa gtt aaa act ggg gta gat gct att aca gag gta        144
Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gaa tgc ttc cta aac cca gaa atg ggg gat cca gat gaa aac ctt agg        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg           
    50                  55                  60                            

ggc ttt agt cta aag cta agt gtt caa aat gac ttt agc agt gat agc        240
Gly Phe Ser Leu Lys Leu Ser Val Gln Asn Asp Phe Ser Ser Asp Ser           
65                  70                  75                  80            

cca cag aga aaa atg ctt ccc tgt tac agc aca gca aga att ccc ctg        288
Pro Gln Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

ccc aat tta aat gag gac cta acc tgt gga aat cta ctg atg tgg gag        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu           
            100                 105                 110                   

gct gta act gta caa aca gag gtt att gga ata act agc atg ctt aac        384
Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctt cat gca ggg tca caa aaa gtg cat gag aat ggt gga gga aaa cct        432
Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro           
    130                 135                 140                           

att caa ggc agt aat ttc cac ttc ttt gct gtt ggt gga gac ccc ttg        480
Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gaa atg cag gga gtg cta atg aat tac aag aca aag tac cca gat ggt        528
Glu Met Gln Gly Val Leu Met Asn Tyr Lys Thr Lys Tyr Pro Asp Gly           
                165                 170                 175               

act gta acc cct aaa aac cca aca gcc cag tcc cag gta atg aat act        576
Thr Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gac cat aag gcc tat ttg gac aaa aac aat gct tat cca gtt gag tgc        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg gtt cct gat ccc agt aga aat gaa aat act agg tat ttt ggg act        672
Trp Val Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

ttc aca gga ggg gaa aat gtt ccc cca gta ctt cat gtg acc aac aca        720
Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gct acc aca gtg ttg cta gat gaa cag ggt gtg ggg ccc ctt tgt aaa        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gct gat agc ctg tat gtt tca gct gct gat att tgt ggc ctg ttt act        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aac agc tct gga aca caa cag tgg aga ggc ctt gca aga tat ttt aag        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys           
        275                 280                 285                       

atc cgc ctg aga aaa aga tct gta aag aat cct tac cca att tcc ttt        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ttg cta agt gac ctt ata aac agg aga acc cag aga gtg gat ggg cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln           
305                 310                 315                 320           

cct atg tat ggt atg gaa tcc cag gta gag gag gtt agg gtg ttt gat       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggc aca gaa aga ctt cca ggg gac cca gat atg ata aga tat att gac       1056
Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aaa cag gga caa ttg caa aca aaa atg gtt taa                           1089
Lys Gln Gly Gln Leu Gln Thr Lys Met Val                                   
        355                 360                                           


<210>  2
<211>  362
<212>  PRT
<213>  BK virus

<400>  2

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Val Gln Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Gln Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Lys Thr Lys Tyr Pro Asp Gly 
                165                 170                 175     


Thr Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Val Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  3
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype Ib2

<400>  3
atg gcc cca acc aaa aga aaa gga gag tgt cca ggg gca gct ccc aaa         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys           
1               5                   10                  15                

aag cca aag gaa ccc gtg caa gtg cca aaa ctg cta ata aaa gga gga         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gta gaa gtt cta gaa gtt aaa act ggg cta gat gct ata aca gag gta        144
Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gaa tgc ttc cta aac cca gaa atg ggg gat cca aat gaa aac ctt agg        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asn Glu Asn Leu Arg           
    50                  55                  60                            

ggc ttt agt cta aag cta agt gct gaa aat gac ttt agc agt gat agc        240
Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser           
65                  70                  75                  80            

cca gaa aga aaa atg ctt ccc tgt tac agc aca gca aga att ccc ctc        288
Pro Glu Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

ccc aat tta aat gag gac cta acc tgt gga aat cta ctg atg tgg gag        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu           
            100                 105                 110                   

gct gta aca gta caa aca gag gtc att gga ata act agc atg ctt aac        384
Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctt cat gca ggg tca caa aaa gtg cat gag cat ggt gga ggt aaa cct        432
Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro           
    130                 135                 140                           

att caa ggc agt aat ttc cac ttt ttt gct gtt ggt gga gac ccc ttg        480
Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gaa atg cag gga gtg cta atg aat tac agg aca aag tac cca gaa ggt        528
Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly           
                165                 170                 175               

act ata acc cca aaa aac cca aca gcc cag tcc cag gta atg aat act        576
Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gac cat aag gcc tat ttg gac aaa aac aat gct tat cca gtt gag tgc        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg att cct gat ccc agt aga aat gaa aat act agg tat ttt ggg act        672
Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

ttc aca gga ggg gaa aat gtt ccc cca gta ctt cat gtg acc aac aca        720
Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gct acc aca gtg ttg cta gat gaa cag ggt gtg ggg cct ctt tgt aaa        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gct gat agc ctg tat gtt tca gct gct gat att tgt ggc ctg ttt act        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aac agc tct gga aca caa cag tgg aga ggc ctt gca aga tat ttt aag        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys           
        275                 280                 285                       

att cgc ctg aga aaa aga tct gta aaa aat cct tac cca att tcc ttt        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ttg cta agt gac ctt ata aac agg aga acc cag aga gtg gat ggg cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln           
305                 310                 315                 320           

cct atg tat ggt atg gaa tcc cag gta gaa gag gtt agg gtg ttt gat       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggc aca gaa aaa ctt cca ggg gac cca gat atg ata aga tat att gac       1056
Gly Thr Glu Lys Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aaa caa gga caa ttg caa acc aaa atg ctt taa                           1089
Lys Gln Gly Gln Leu Gln Thr Lys Met Leu                                   
        355                 360                                           


<210>  4
<211>  362
<212>  PRT
<213>  BK virus

<400>  4

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asn Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Glu Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Lys Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  5
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype II

<400>  5
atg gcc cca acc aaa aga aag gga gag tgt cca ggg gca gct ccc aga         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Arg           
1               5                   10                  15                

aag cca aag gaa ccc gtg caa gtg cca aaa cta cta ata aaa gga gga         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gta gaa gtt cta gaa gtt aaa act ggg gta gat gct ata aca gag gta        144
Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gaa tgc ttt cta aac cca gaa atg ggg gat cca gat gat aac ctt agg        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp Asn Leu Arg           
    50                  55                  60                            

ggc tat agt cta aag cta act gct gaa aat gcc ttt gac agt gat agc        240
Gly Tyr Ser Leu Lys Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser           
65                  70                  75                  80            

cca gac aaa aaa atg ctt cct tgt tac agc aca gca aga att cca ctg        288
Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

ccc aat cta aat gag gac cta acc tgt gga aat cta cta atg tgg gag        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu           
            100                 105                 110                   

gct gta act gta aaa aca gag gtt att gga ata act agc atg ctt aac        384
Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctt cat gca ggg tcc caa aaa gtt cat gag aat ggt gga ggc aaa cct        432
Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro           
    130                 135                 140                           

gtc caa ggc agt aat ttc cac ttc ttt gct gtg ggt gga gac ccc ttg        480
Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gaa atg cag gga gtg cta atg aat tac aga aca aag tac cca caa ggt        528
Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly           
                165                 170                 175               

act ata acc cct aaa aac cct aca gct cag tcc cag gta atg aat act        576
Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gat cat aag gcc tat ttg gac aaa aac aat gct tat cca gtt gag tgc        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg att cct gat cct agt aga aat gaa aat act agg tat ttt gga act        672
Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

tac aca gga ggg gaa aat gtt ccc cca gta ctt cat gtt acc aac aca        720
Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gct acc aca gtg ttg ctg gat gaa cag ggt gtg ggg cct ctg tgt aaa        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gct gat agc ctg tat gtt tca gct gct gat att tgt ggg ctg ttt act        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aac agc tct ggg aca caa cag tgg aga ggc ctt gca aga tat ttt aag        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys           
        275                 280                 285                       

att cgc ctg aga aaa aga tct gtg aag aat cct tac cca att tcc ttt        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ttg cta agt gac ctt ata aac agg aga acc caa aaa gtg gat ggg cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln           
305                 310                 315                 320           

cct atg tat ggt atg gaa tct cag gtt gag gag gtg agg gtg ttt gat       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggc aca gaa cag ctt cca ggg gac cca gat atg ata aga tat att gac       1056
Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aga caa gga caa ttg caa aca aaa atg gtt taa                           1089
Arg Gln Gly Gln Leu Gln Thr Lys Met Val                                   
        355                 360                                           


<210>  6
<211>  362
<212>  PRT
<213>  BK virus

<400>  6

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Arg 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp Asn Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Leu Lys Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  7
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype III

<400>  7
atg gcc cca acc aaa aga aaa gga gag tgt cca ggg gca gct ccc aaa         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys           
1               5                   10                  15                

aag cca aag gaa ccc gtg caa gtg cca aaa cta cta ata aaa gga gga         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gta gaa gtt cta gaa gtt aaa act ggg gta gat gct ata aca gag gta        144
Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gaa tgc ttt cta aac cca gaa atg ggg gat cca gat gat cac ctt agg        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp His Leu Arg           
    50                  55                  60                            

ggc tat agt cag cac cta act gct gaa aat gcc ttt gac agt gat agc        240
Gly Tyr Ser Gln His Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser           
65                  70                  75                  80            

cca gac aaa aaa atg ctt cct tgt tac agt aca gca aga att cca ctg        288
Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

ccc aac cta aat gag gac cta acc tgt gga aat cta cta atg tgg gag        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu           
            100                 105                 110                   

gct gta act gta aaa aca gag gtt att gga ata act agc atg ctt aac        384
Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctt cat gca ggg tcc caa aaa gtt cat gag aat ggt gga ggt aaa cct        432
Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro           
    130                 135                 140                           

gtc caa ggc agt aat ttc cac ttc ttt gct gtg ggt gga gac ccc ttg        480
Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gaa atg cag gga gtg cta atg aat tac aga aca aag tac cca caa ggt        528
Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly           
                165                 170                 175               

act ata acc cct aaa aac cct aca gct cag tcc cag gta atg aat act        576
Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gat cat aag gcc tat ttg gac aaa aac aat gct tat cca gtt gag tgc        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg att cct gat cct agt aaa aat gaa aat act agg tat ttt gga act        672
Trp Ile Pro Asp Pro Ser Lys Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

tac aca gga ggg gaa aat gtt cct cca gta ctt cat gtt acc aac aca        720
Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gct acc aca gtg ttg ctg gat gaa cag ggt gtg ggg cct ctg tgt aaa        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gct gat agc ctg tat gtt tca gct gct gat att tgt ggg ctg ttt act        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aac agc tct ggg aca caa cag tgg aga ggc ctt gca aga tat ttt aag        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys           
        275                 280                 285                       

att cgc ctg aga aaa aga tct gtg aag aat cct tac cca att tcc ttt        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ttg cta agt gac ctt ata aac agg aga acc caa aaa gtg gat ggg cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln           
305                 310                 315                 320           

cct atg tat ggt atg gaa tct cag gtt gag gag gta agg gtg ttt gat       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggc aca gaa cag ctt cca ggg gac cca gat atg ata aga tat att gac       1056
Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aga caa gga caa ttg caa aca aaa atg gtt taa                           1089
Arg Gln Gly Gln Leu Gln Thr Lys Met Val                                   
        355                 360                                           


<210>  8
<211>  362
<212>  PRT
<213>  BK virus

<400>  8

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp His Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Gln His Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Val Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Lys Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Lys Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  9
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype IV

<400>  9
atg gcc cca acc aaa aga aag gga gag tgt cca ggg gca gct ccc aaa         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys           
1               5                   10                  15                

aag cca aag gaa ccc gtg caa gtg cca aaa cta cta ata aaa gga gga         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gta gaa gtt cta gaa gtt aaa act ggg cta gat gct ata aca gaa gta        144
Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gaa tgc ttt cta aat cca gaa atg ggg gat cca gat aat gac ctt agg        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asn Asp Leu Arg           
    50                  55                  60                            

ggc tat agt cta aga cta act gct gaa act gcc ttt gag agt gat agc        240
Gly Tyr Ser Leu Arg Leu Thr Ala Glu Thr Ala Phe Glu Ser Asp Ser           
65                  70                  75                  80            

cca gac aga aaa atg ctt ccc tgt tac agc aca gca aga att cca cta        288
Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

cct aat ttg aat gag gat cta acc tgt gga agt cta cta atg tgg gag        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Ser Leu Leu Met Trp Glu           
            100                 105                 110                   

gct gtg act gta aaa aca gag gtt att gga ata act agt atg ctt aac        384
Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctt cat gca ggg tca cag aaa gta cat gaa aat ggt gga ggc aaa cct        432
Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro           
    130                 135                 140                           

att caa ggc agc aat ttt cac ttt ttt gct gtg ggt ggg gac ccc ttg        480
Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gaa atg cag gga gta ctt atg aac tac aga aca aag tac cca gaa ggt        528
Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly           
                165                 170                 175               

act gtc acc cca aaa aat ccc aca gct cag tcc cag gta atg aat act        576
Thr Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gac cat aag gcc tac ttg gac aaa aac aat gct tat cca gtt gaa tgc        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg att cct gac cct agt aga aat gaa aat act agg tat ttt gga aca        672
Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

tac aca gga ggg gaa aat gtt ccc cca gta ctt cat gta acc aac aca        720
Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gct acc aca gtg ttg ctg gat gaa cag ggt gtg ggg cct ctg tgt aaa        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gct gat agc ctg tat gtt tca gct gct gat att tgt gga ctg ttt act        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aac agc tct gga aca caa cag tgg agg ggc ctt cca aga tat ttt aag        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Pro Arg Tyr Phe Lys           
        275                 280                 285                       

att cgc ctg aga aaa aga tct gta aag aac cct tac cca att tcc ttt        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ttg ctt agt gac ctt ata aac agg aga acc cag aga gtg gat ggg cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln           
305                 310                 315                 320           

cct atg tat ggt atg gag tct cag gtg gag gag gtc agg gtg ttt gat       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggc aca gaa cag ctt cca ggg gac cca gat atg ata aga tat att gac       1056
Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aga cag gga caa ttg caa aca aaa atg gtt taa                           1089
Arg Gln Gly Gln Leu Gln Thr Lys Met Val                                   
        355                 360                                           


<210>  10
<211>  362
<212>  PRT
<213>  BK virus

<400>  10

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asn Asp Leu Arg 
    50                  55                  60                  


Gly Tyr Ser Leu Arg Leu Thr Ala Glu Thr Ala Phe Glu Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Ser Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Tyr Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Pro Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Gln Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Arg Gln Gly Gln Leu Gln Thr Lys Met Val 
        355                 360         


<210>  11
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6' et 'H6', chane lourde, CDR1


<220>
<221>  CDS
<222>  (1)..(15)

<400>  11
ggc tac ttt atg aac                                                     15
Gly Tyr Phe Met Asn                                                       
1               5                                                         


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Tyr Phe Met Asn 
1               5   


<210>  13
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6' et 'H6', chane lourde, CDR2


<220>
<221>  CDS
<222>  (1)..(51)

<400>  13
cgt att aat cct tac aat ggt gat act ttc tac aac cag aag ttc aag         48
Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys           
1               5                   10                  15                

ggc                                                                     51
Gly                                                                       
                                                                          


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6' et 'H6', chane lourde, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  15
tat tac tac ggc gac tac ttt gac tac                                     27
Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr                                       
1               5                                                         


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr 
1               5                   


<210>  17
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6' et 'H6', chane lourde, rgion variable


<220>
<221>  CDS
<222>  (1)..(411)

<400>  17
atg gga tgg agc tgt atc ttt ctc ttt ctc ctg tca gta act gta ggt         48
Met Gly Trp Ser Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Val Gly           
1               5                   10                  15                

gtg ttc tct gag gtt cag ctg cag cag tct gga cct gag ctg gtg aag         96
Val Phe Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys           
            20                  25                  30                    

cct ggg gct tca gtg aag ata tcc tgc aag gct tct ggt tac tca ttt        144
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe           
        35                  40                  45                        

act ggc tac ttt atg aac tgg gtg aag cag agc cat gga aag agc ctt        192
Thr Gly Tyr Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu           
    50                  55                  60                            

gag tgg att gga cgt att aat cct tac aat ggt gat act ttc tac aac        240
Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn           
65                  70                  75                  80            

cag aag ttc aag ggc aag gcc aca ttg act gta gac aaa tcc tct agc        288
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser           
                85                  90                  95                

aca gcc cac atg gag ctc ctg agc ctg aca tct gag gac tct gca gtc        336
Thr Ala His Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val           
            100                 105                 110                   

tat tat tgt gga agt tat tac tac ggc gac tac ttt gac tac tgg ggc        384
Tyr Tyr Cys Gly Ser Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly           
        115                 120                 125                       

caa ggc acc act ctc aca gtc tcc tca                                    411
Gln Gly Thr Thr Leu Thr Val Ser Ser                                       
    130                 135                                               


<210>  18
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Gly Trp Ser Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Val Phe Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala His Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Ser Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135         


<210>  19
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6' et 'H6', chane lourde


<220>
<221>  CDS
<222>  (1)..(1386)

<400>  19
atg gga tgg agc tgt atc ttt ctc ttt ctc ctg tca gta act gta ggt         48
Met Gly Trp Ser Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Val Gly           
1               5                   10                  15                

gtg ttc tct gag gtt cag ctg cag cag tct gga cct gag ctg gtg aag         96
Val Phe Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys           
            20                  25                  30                    

cct ggg gct tca gtg aag ata tcc tgc aag gct tct ggt tac tca ttt        144
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe           
        35                  40                  45                        

act ggc tac ttt atg aac tgg gtg aag cag agc cat gga aag agc ctt        192
Thr Gly Tyr Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu           
    50                  55                  60                            

gag tgg att gga cgt att aat cct tac aat ggt gat act ttc tac aac        240
Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn           
65                  70                  75                  80            

cag aag ttc aag ggc aag gcc aca ttg act gta gac aaa tcc tct agc        288
Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser           
                85                  90                  95                

aca gcc cac atg gag ctc ctg agc ctg aca tct gag gac tct gca gtc        336
Thr Ala His Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val           
            100                 105                 110                   

tat tat tgt gga agt tat tac tac ggc gac tac ttt gac tac tgg ggc        384
Tyr Tyr Cys Gly Ser Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly           
        115                 120                 125                       

caa ggc acc act ctc aca gtc tcc tca gcc aaa acg aca ccc cca tct        432
Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser           
    130                 135                 140                           

gtc tat cca ctg gcc cct gga tct gct gcc caa act aac tcc atg gtg        480
Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val           
145                 150                 155                 160           

acc ctg gga tgc ctg gtc aag ggc tat ttc cct gag cca gtg aca gtg        528
Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val           
                165                 170                 175               

acc tgg aac tct gga tcc ctg tcc agc ggt gtg cac acc ttc cca gct        576
Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala           
            180                 185                 190                   

gtc ctg cag tct gac ctc tac act ctg agc agc tca gtg act gtc ccc        624
Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro           
        195                 200                 205                       

tcc agc acc tgg ccc agc gag acc gtc acc tgc aac gtt gcc cac ccg        672
Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro           
    210                 215                 220                           

gcc agc agc acc aag gtg gac aag aaa att gtg ccc agg gat tgt ggt        720
Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly           
225                 230                 235                 240           

tgt aag cct tgc ata tgt aca gtc cca gaa gta tca tct gtc ttc atc        768
Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile           
                245                 250                 255               

ttc ccc cca aag ccc aag gat gtg ctc acc att act ctg act cct aag        816
Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys           
            260                 265                 270                   

gtc acg tgt gtt gtg gta gac atc agc aag gat gat ccc gag gtc cag        864
Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln           
        275                 280                 285                       

ttc agc tgg ttt gta gat gat gtg gag gtg cac aca gct cag acg caa        912
Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln           
    290                 295                 300                           

ccc cgg gag gag cag ttc aac agc act ttc cgc tca gtc agt gaa ctt        960
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu           
305                 310                 315                 320           

ccc atc atg cac cag gac tgg ctc aat ggc aag gag ttc aaa tgc agg       1008
Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg           
                325                 330                 335               

gtc aac agt gca gct ttc cct gcc ccc atc gag aaa acc atc tcc aaa       1056
Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys           
            340                 345                 350                   

acc aaa ggc aga ccg aag gct cca cag gtg tac acc att cca cct ccc       1104
Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro           
        355                 360                 365                       

aag gag cag atg gcc aag gat aaa gtc agt ctg acc tgc atg ata aca       1152
Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr           
    370                 375                 380                           

gac ttc ttc cct gaa gac att act gtg gag tgg cag tgg aat ggg cag       1200
Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln           
385                 390                 395                 400           

cca gcg gag aac tac aag aac act cag ccc atc atg gac aca gat ggc       1248
Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly           
                405                 410                 415               

tct tac ttc gtc tac agc aag ctc aat gtg cag aag agc aac tgg gag       1296
Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu           
            420                 425                 430                   

gca gga aat act ttc acc tgc tct gtg tta cat gag ggc ctg cac aac       1344
Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn           
        435                 440                 445                       

cac cat act gag aag agc ctc tcc cac tct cct ggt aaa tga               1386
His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys                       
    450                 455                 460                           


<210>  20
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Gly Trp Ser Cys Ile Phe Leu Phe Leu Leu Ser Val Thr Val Gly 
1               5                   10                  15      


Val Phe Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe 
        35                  40                  45              


Thr Gly Tyr Phe Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Arg Ile Asn Pro Tyr Asn Gly Asp Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala His Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Gly Ser Tyr Tyr Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser 
    130                 135                 140                 


Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val 
145                 150                 155                 160 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
            180                 185                 190         


Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro 
        195                 200                 205             


Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro 
    210                 215                 220                 


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly 
225                 230                 235                 240 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
305                 310                 315                 320 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
                325                 330                 335     


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
        355                 360                 365             


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
    370                 375                 380                 


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
385                 390                 395                 400 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
                405                 410                 415     


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
            420                 425                 430         


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
        435                 440                 445             


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460     


<210>  21
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6', chane lgre, CDR1


<220>
<221>  CDS
<222>  (1)..(51)

<400>  21
aag tcc agt cag agc ctt tta tat agt agc aat caa aag aac tac ttg         48
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu           
1               5                   10                  15                

gcc                                                                     51
Ala                                                                       
                                                                          


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  23
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6', chane lgre, CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  23
tgg gca tcc act agg gaa tct                                             21
Trp Ala Ser Thr Arg Glu Ser                                               
1               5                                                         


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  25
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6', chane lgre, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  25
cag caa tat tat agc tat ccg ctc acg                                     27
Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr                                       
1               5                                                         


<210>  26
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  27
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6', chane lgre, rgion variable


<220>
<221>  CDS
<222>  (1)..(399)

<400>  27
atg gat tca cag gcc cag gtt ctt atg tta ctg ctg cta tgg gta tct         48
Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser           
1               5                   10                  15                

ggt acc tgt ggg gac att gtg atg tca cag tct cca tcc tcc cta gct         96
Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala           
            20                  25                  30                    

gtg tca gtt gga gag aag gtt act atg agc tgc aag tcc agt cag agc        144
Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser           
        35                  40                  45                        

ctt tta tat agt agc aat caa aag aac tac ttg gcc tgg tac cag cag        192
Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln           
    50                  55                  60                            

aaa cca ggg cag tct cct aaa ctg ctg att tac tgg gca tcc act agg        240
Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg           
65                  70                  75                  80            

gaa tct ggg gtc cct gat cgc ttc aca ggc agt gga tct ggg aca gat        288
Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp           
                85                  90                  95                

ttc act ctc acc atc agc agt gtg aag gct gaa gac ctg gca gtt tat        336
Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr           
            100                 105                 110                   

tac tgt cag caa tat tat agc tat ccg ctc acg ttc ggt gct ggg acc        384
Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr           
        115                 120                 125                       

aag ctg gag ctg aaa                                                    399
Lys Leu Glu Leu Lys                                                       
    130                                                                   


<210>  28
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys 
    130             


<210>  29
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'F6', chane lgre


<220>
<221>  CDS
<222>  (1)..(723)

<400>  29
atg gat tca cag gcc cag gtt ctt atg tta ctg ctg cta tgg gta tct         48
Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser           
1               5                   10                  15                

ggt acc tgt ggg gac att gtg atg tca cag tct cca tcc tcc cta gct         96
Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala           
            20                  25                  30                    

gtg tca gtt gga gag aag gtt act atg agc tgc aag tcc agt cag agc        144
Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser           
        35                  40                  45                        

ctt tta tat agt agc aat caa aag aac tac ttg gcc tgg tac cag cag        192
Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln           
    50                  55                  60                            

aaa cca ggg cag tct cct aaa ctg ctg att tac tgg gca tcc act agg        240
Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg           
65                  70                  75                  80            

gaa tct ggg gtc cct gat cgc ttc aca ggc agt gga tct ggg aca gat        288
Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp           
                85                  90                  95                

ttc act ctc acc atc agc agt gtg aag gct gaa gac ctg gca gtt tat        336
Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr           
            100                 105                 110                   

tac tgt cag caa tat tat agc tat ccg ctc acg ttc ggt gct ggg acc        384
Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr           
        115                 120                 125                       

aag ctg gag ctg aaa cgg gct gat gct gca cca act gta tcc atc ttc        432
Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe           
    130                 135                 140                           

cca cca tcc agt gag cag tta aca tct gga ggt gcc tca gtc gtg tgc        480
Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys           
145                 150                 155                 160           

ttc ttg aac aac ttc tac ccc aaa gac atc aat gtc aag tgg aag att        528
Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile           
                165                 170                 175               

gat ggc agt gaa cga caa aat ggc gtc ctg aac agt tgg act gat cag        576
Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln           
            180                 185                 190                   

gac agc aaa gac agc acc tac agc atg agc agc acc ctc acg ttg acc        624
Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr           
        195                 200                 205                       

aag gac gag tat gaa cga cat aac agc tat acc tgt gag gcc act cac        672
Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His           
    210                 215                 220                           

aag aca tca act tca ccc att gtc aag agc ttc aac agg aat gag tgt        720
Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys           
225                 230                 235                 240           

tag                                                                    723


<210>  30
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Asp Ser Gln Ala Gln Val Leu Met Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Val Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys 
145                 150                 155                 160 


Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile 
                165                 170                 175     


Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr 
        195                 200                 205             


Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His 
    210                 215                 220                 


Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 240 


<210>  31
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'H6', chane lgre, CDR1


<220>
<221>  CDS
<222>  (1)..(33)

<400>  31
aag gcc agt cag agt gtg agt aat gat gta gct                             33
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala                               
1               5                   10                                    


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  33
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'H6', chane lgre, CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  33
tat gca tcc aat cgc tac act                                             21
Tyr Ala Ser Asn Arg Tyr Thr                                               
1               5                                                         


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  35
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'H6', chane lgre, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  35
cag cag gat tat agt tct ccg ctc acg                                     27
Gln Gln Asp Tyr Ser Ser Pro Leu Thr                                       
1               5                                                         


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Gln Gln Asp Tyr Ser Ser Pro Leu Thr 
1               5                   


<210>  37
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'H6', chane lgre, rgion variable


<220>
<221>  CDS
<222>  (1)..(381)

<400>  37
atg aag tca cag acc cag gtc ttc gta ttt cta ctg ctc tgt gtg tct         48
Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser           
1               5                   10                  15                

ggt gct cat ggg agt att gtg atg acc cag att ccc aaa ttc ctg ctt         96
Gly Ala His Gly Ser Ile Val Met Thr Gln Ile Pro Lys Phe Leu Leu           
            20                  25                  30                    

gta tca gaa gga gac agg gtt acc ata acc tgc aag gcc agt cag agt        144
Val Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser           
        35                  40                  45                        

gtg agt aat gat gta gct tgg tac caa cag aag tca ggg cag tct cct        192
Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro           
    50                  55                  60                            

aaa ctg ctg ata tac tat gca tcc aat cgc tac act gga gtc cct gat        240
Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp           
65                  70                  75                  80            

cgc ttc act ggc agt gga tat ggg acg gat ttc act ttc acc atc agc        288
Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser           
                85                  90                  95                

act gtg cag gct gaa gac ctg gca gtt tat ttc tgt cag cag gat tat        336
Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr           
            100                 105                 110                   

agt tct ccg ctc acg ttc ggt gct ggg acc aag ctg gag ctg aaa            381
Ser Ser Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys               
        115                 120                 125                       


<210>  38
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Ser Ile Val Met Thr Gln Ile Pro Lys Phe Leu Leu 
            20                  25                  30          


Val Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         


Ser Ser Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  39
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 'H6', chane lgre


<220>
<221>  CDS
<222>  (1)..(705)

<400>  39
atg aag tca cag acc cag gtc ttc gta ttt cta ctg ctc tgt gtg tct         48
Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser           
1               5                   10                  15                

ggt gct cat ggg agt att gtg atg acc cag att ccc aaa ttc ctg ctt         96
Gly Ala His Gly Ser Ile Val Met Thr Gln Ile Pro Lys Phe Leu Leu           
            20                  25                  30                    

gta tca gaa gga gac agg gtt acc ata acc tgc aag gcc agt cag agt        144
Val Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser           
        35                  40                  45                        

gtg agt aat gat gta gct tgg tac caa cag aag tca ggg cag tct cct        192
Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro           
    50                  55                  60                            

aaa ctg ctg ata tac tat gca tcc aat cgc tac act gga gtc cct gat        240
Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp           
65                  70                  75                  80            

cgc ttc act ggc agt gga tat ggg acg gat ttc act ttc acc atc agc        288
Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser           
                85                  90                  95                

act gtg cag gct gaa gac ctg gca gtt tat ttc tgt cag cag gat tat        336
Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr           
            100                 105                 110                   

agt tct ccg ctc acg ttc ggt gct ggg acc aag ctg gag ctg aaa cgg        384
Ser Ser Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg           
        115                 120                 125                       

gct gat gct gca cca act gta tcc atc ttc cca cca tcc agt gag cag        432
Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln           
    130                 135                 140                           

tta aca tct gga ggt gcc tca gtc gtg tgc ttc ttg aac aac ttc tac        480
Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr           
145                 150                 155                 160           

ccc aaa gac atc aat gtc aag tgg aag att gat ggc agt gaa cga caa        528
Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln           
                165                 170                 175               

aat ggc gtc ctg aac agt tgg act gat cag gac agc aaa gac agc acc        576
Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr           
            180                 185                 190                   

tac agc atg agc agc acc ctc acg ttg acc aag gac gag tat gaa cga        624
Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg           
        195                 200                 205                       

cat aac agc tat acc tgt gag gcc act cac aag aca tca act tca ccc        672
His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro           
    210                 215                 220                           

att gtc aag agc ttc aac agg aat gag tgt tag                            705
Ile Val Lys Ser Phe Asn Arg Asn Glu Cys                                   
225                 230                                                   


<210>  40
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Ser Ile Val Met Thr Gln Ile Pro Lys Phe Leu Leu 
            20                  25                  30          


Val Ser Glu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Ser Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         


Ser Ser Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', '14D6' et '18A2', chane lourde, CDR1


<220>
<221>  CDS
<222>  (1)..(18)

<400>  41
agt ggt tat tac tgg aac                                                 18
Ser Gly Tyr Tyr Trp Asn                                                   
1               5                                                         


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Ser Gly Tyr Tyr Trp Asn 
1               5       


<210>  43
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', '14D6' et '18A2', chane lourde, CDR2


<220>
<221>  CDS
<222>  (1)..(48)

<400>  43
tac ata agc tac gac ggt agc aat aac tac aac cca tct ctc aaa aat         48
Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn           
1               5                   10                  15                


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  44

Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  45
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lourde, CDR3


<220>
<221>  CDS
<222>  (1)..(30)

<400>  45
gtg gat ggt aac tcc tgg tac ttc gat gtc                                 30
Val Asp Gly Asn Ser Trp Tyr Phe Asp Val                                   
1               5                   10                                    


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  46

Val Asp Gly Asn Ser Trp Tyr Phe Asp Val 
1               5                   10  


<210>  47
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lourde, rgion variable


<220>
<221>  CDS
<222>  (1)..(411)

<400>  47
atg aaa gtg ttg agt ctg ttg tac ctg ttg aca gcc att cct ggt atc         48
Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile           
1               5                   10                  15                

ctg tct gat gta cag ctt cag gag tca gga cct ggc ctc gtg aaa cct         96
Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro           
            20                  25                  30                    

tct cag tct ctg tct ctc acc tgc tct gtc act ggc tac tcc atc acc        144
Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr           
        35                  40                  45                        

agt ggt tat tac tgg aac tgg atc cgg cag ttt cca gga aac aaa ctg        192
Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu           
    50                  55                  60                            

gaa tgg atg ggc tac ata agc tac gac ggt agc aat aac tac aac cca        240
Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro           
65                  70                  75                  80            

tct ctc aaa aat cga atc tcc atc act cgt gac aca tct aag aac cag        288
Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln           
                85                  90                  95                

ttt ttc ctg aag ttg aat tct gtg act act gag gac aca gct aca tat        336
Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr           
            100                 105                 110                   

tat tgt gca aga gtg gat ggt aac tcc tgg tac ttc gat gtc tgg ggc        384
Tyr Cys Ala Arg Val Asp Gly Asn Ser Trp Tyr Phe Asp Val Trp Gly           
        115                 120                 125                       

gca ggg acc acg gtc acc gtc tcc tca                                    411
Ala Gly Thr Thr Val Thr Val Ser Ser                                       
    130                 135                                               


<210>  48
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  48

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Val Asp Gly Asn Ser Trp Tyr Phe Asp Val Trp Gly 
        115                 120                 125             


Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  49
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lgre, CDR1


<220>
<221>  CDS
<222>  (1)..(33)

<400>  49
aag gca agt gag gac ata tat aat cgg tta gcc                             33
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala                               
1               5                   10                                    


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  50

Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala 
1               5                   10      


<210>  51
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lgre, CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  51
ggt gca acc agt ttg gaa act                                             21
Gly Ala Thr Ser Leu Glu Thr                                               
1               5                                                         


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Gly Ala Thr Ser Leu Glu Thr 
1               5           


<210>  53
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lgre, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  53
caa cag tat tgg agt att ctg ctc acg                                     27
Gln Gln Tyr Trp Ser Ile Leu Leu Thr                                       
1               5                                                         


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  54

Gln Gln Tyr Trp Ser Ile Leu Leu Thr 
1               5                   


<210>  55
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '9B1', chane lgre, rgion variable


<220>
<221>  CDS
<222>  (1)..(381)

<400>  55
atg aag ttt cct tct caa ctt ctg ctc tta ctg ctg ttt gga atc cca         48
Met Lys Phe Pro Ser Gln Leu Leu Leu Leu Leu Leu Phe Gly Ile Pro           
1               5                   10                  15                

ggc atg ata tgt gac atc cag atg aca caa tct tca tcc tcc ttt tct         96
Gly Met Ile Cys Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser           
            20                  25                  30                    

gta tct cta gga gac aga gtc acc att act tgc aag gca agt gag gac        144
Val Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp           
        35                  40                  45                        

ata tat aat cgg tta gcc tgg tat cag cag aaa cca gga aat gct cct        192
Ile Tyr Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro           
    50                  55                  60                            

agg ctc tta ata tct ggt gca acc agt ttg gaa act ggg gtt cct tca        240
Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser           
65                  70                  75                  80            

aga ttc agt ggc agt gga tct gga aag gat tac act ctc agc att acc        288
Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr           
                85                  90                  95                

agt ctt cag act gaa gat gtt gct act tat tac tgt caa cag tat tgg        336
Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp           
            100                 105                 110                   

agt att ctg ctc acg ttc ggt gct ggg acc aag ctg gag ctg aaa            381
Ser Ile Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys               
        115                 120                 125                       


<210>  56
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  56

Met Lys Phe Pro Ser Gln Leu Leu Leu Leu Leu Leu Phe Gly Ile Pro 
1               5                   10                  15      


Gly Met Ile Cys Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser 
            20                  25                  30          


Val Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp 
        35                  40                  45              


Ile Tyr Asn Arg Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr 
                85                  90                  95      


Ser Leu Gln Thr Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp 
            100                 105                 110         


Ser Ile Leu Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125         


<210>  57
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lourde, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  57
tgg gta ggg gac tgg tac ttc gat gtc                                     27
Trp Val Gly Asp Trp Tyr Phe Asp Val                                       
1               5                                                         


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  58

Trp Val Gly Asp Trp Tyr Phe Asp Val 
1               5                   


<210>  59
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lourde, rgion variable


<220>
<221>  CDS
<222>  (1)..(408)

<400>  59
atg aaa gtg ttg agt ctg ttg tac ctg ttg aca gcc att cct ggt atc         48
Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile           
1               5                   10                  15                

ctg tct gat gta cag ctt cag gag tca gga cct ggc ctc gtg aaa cct         96
Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro           
            20                  25                  30                    

tct cag tct ctg tct ctc acc tgc tct gtc act ggc tac tcc atc acc        144
Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr           
        35                  40                  45                        

agt ggt tat tac tgg aac tgg atc cgg cag ttt cca gga aac aaa ctg        192
Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu           
    50                  55                  60                            

gaa tgg atg ggc tac ata agc tac gac ggt agc aat aac tac aac cca        240
Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro           
65                  70                  75                  80            

tct ctc aaa aat cga atc tcc atc act cgt gac aca tct aag aac cag        288
Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln           
                85                  90                  95                

ttt ttc ctg aag ttg aat tct gtg act act gag gac aca gct aca tat        336
Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr           
            100                 105                 110                   

tac tgt gca aga tgg gta ggg gac tgg tac ttc gat gtc tgg ggc gca        384
Tyr Cys Ala Arg Trp Val Gly Asp Trp Tyr Phe Asp Val Trp Gly Ala           
        115                 120                 125                       

ggg acc acg gtc acc gtc tcc tca                                        408
Gly Thr Thr Val Thr Val Ser Ser                                           
    130                 135                                               


<210>  60
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  60

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Trp Val Gly Asp Trp Tyr Phe Asp Val Trp Gly Ala 
        115                 120                 125             


Gly Thr Thr Val Thr Val Ser Ser 
    130                 135     


<210>  61
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lgre, CDR1


<220>
<221>  CDS
<222>  (1)..(45)

<400>  61
agg gcc agc aaa agt gtc agt cca tct ggc tat agt tat atg cac             45
Arg Ala Ser Lys Ser Val Ser Pro Ser Gly Tyr Ser Tyr Met His               
1               5                   10                  15                


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Arg Ala Ser Lys Ser Val Ser Pro Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  63
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lgre, CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  63
ctt gca tcc aac cta gaa tct                                             21
Leu Ala Ser Asn Leu Glu Ser                                               
1               5                                                         


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  64

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  65
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lgre, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  65
cag cac agt agg gag ctt ccg ctc acg                                     27
Gln His Ser Arg Glu Leu Pro Leu Thr                                       
1               5                                                         


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  66

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  67
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '14D6', chane lgre, rgion variable


<220>
<221>  CDS
<222>  (1)..(393)

<400>  67
atg gag aca gac aca ctc ctg tta tgg gta ctg ctg ctc tgg gtt cca         48
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro           
1               5                   10                  15                

ggt tcc act ggt gac att gtg ctg aca cag tct cct gct tcc tta gct         96
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala           
            20                  25                  30                    

gta tct ctg ggg cag agg gcc acc atc tca tgc agg gcc agc aaa agt        144
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser           
        35                  40                  45                        

gtc agt cca tct ggc tat agt tat atg cac tgg tac caa cag aaa cca        192
Val Ser Pro Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro           
    50                  55                  60                            

gga cag cca ccc aaa ctc ctc atc tat ctt gca tcc aac cta gaa tct        240
Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser           
65                  70                  75                  80            

ggg gtc cct gcc agg ttc agt ggc agt ggg tct ggg aca gac ttc acc        288
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr           
                85                  90                  95                

ctc aac atc cat cct gtg gag gag gag gat gct gca acc tat tac tgt        336
Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys           
            100                 105                 110                   

cag cac agt agg gag ctt ccg ctc acg ttc ggt gct ggg acc aag ctg        384
Gln His Ser Arg Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu           
        115                 120                 125                       

gag ctg aaa                                                            393
Glu Leu Lys                                                               
    130                                                                   


<210>  68
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  68

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser 
        35                  40                  45              


Val Ser Pro Ser Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln His Ser Arg Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  69
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '18A2', chane lourde, CDR3


<220>
<221>  CDS
<222>  (1)..(21)

<400>  69
tgg gag ggg act act gac tac                                             21
Trp Glu Gly Thr Thr Asp Tyr                                               
1               5                                                         


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  70

Trp Glu Gly Thr Thr Asp Tyr 
1               5           


<210>  71
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '18A2', chane lourde, rgion variable


<220>
<221>  CDS
<222>  (1)..(402)

<400>  71
atg aaa gtg ttg agt ctg ttg tac ctg ttg aca gcc att cct ggt atc         48
Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile           
1               5                   10                  15                

ctg tct gat gta cag ctt cag gag tca gga cct ggc ctc gtg aaa cct         96
Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro           
            20                  25                  30                    

tct cag tct ctg tct ctc acc tgc tct gtc act ggc tac tcc atc acc        144
Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr           
        35                  40                  45                        

agt ggt tat tac tgg aac tgg atc cgg cag ttt cca gga aac aaa ctg        192
Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu           
    50                  55                  60                            

gaa tgg atg ggc tac ata agc tac gac ggt agc aat aac tac aac cca        240
Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro           
65                  70                  75                  80            

tct ctc aaa aat cga atc tcc atc act cgt gac aca tct aag aac cag        288
Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln           
                85                  90                  95                

ttt ttc ctg aag ttg aat tct gtg act act gag gac aca gct aca tat        336
Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr           
            100                 105                 110                   

tac tgt gca aga tgg gag ggg act act gac tac tgg ggc caa ggc acc        384
Tyr Cys Ala Arg Trp Glu Gly Thr Thr Asp Tyr Trp Gly Gln Gly Thr           
        115                 120                 125                       

act ctc aca gtc tcc tca                                                402
Thr Leu Thr Val Ser Ser                                                   
    130                                                                   


<210>  72
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  72

Met Lys Val Leu Ser Leu Leu Tyr Leu Leu Thr Ala Ile Pro Gly Ile 
1               5                   10                  15      


Leu Ser Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
            20                  25                  30          


Ser Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr 
        35                  40                  45              


Ser Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Phe Phe Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Trp Glu Gly Thr Thr Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Thr Leu Thr Val Ser Ser 
    130                 


<210>  73
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '18A2', chane lgre, CDR1


<220>
<221>  CDS
<222>  (1)..(48)

<400>  73
aag tca agt cag agc ctc tta gat agt gat gga aag aca tat ttg aat         48
Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn           
1               5                   10                  15                


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  74

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  75
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '18A2', chane lgre, CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  75
ctg gtg tct aaa ctg gac tct                                             21
Leu Val Ser Lys Leu Asp Ser                                               
1               5                                                         


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  76

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  77
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps 418A2', chane lgre, CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  77
tgg caa ggt aca cat ttt cct tac acg                                     27
Trp Gln Gly Thr His Phe Pro Tyr Thr                                       
1               5                                                         


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  78

Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   


<210>  79
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anticorps '18A2', chane lgre, rgion variable


<220>
<221>  CDS
<222>  (1)..(393)

<400>  79
atg agt cct gcc cag ttc ctg ttt ctg tta gtg ttc tgg att cgg gaa         48
Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Phe Trp Ile Arg Glu           
1               5                   10                  15                

acc aac ggt gat gtt gtg atg acc cag act cca ctc act ttg tcg gtt         96
Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val           
            20                  25                  30                    

acc att gga caa cca gcc tcc atc tct tgc aag tca agt cag agc ctc        144
Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu           
        35                  40                  45                        

tta gat agt gat gga aag aca tat ttg aat tgg ttg tta cag agg cca        192
Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro           
    50                  55                  60                            

ggc cag tct cca aag cgc cta atc tat ctg gtg tct aaa ctg gac tct        240
Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser           
65                  70                  75                  80            

gga gtc cct gac agg ttc act ggc agt gga tca ggg aca gat ttc aca        288
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr           
                85                  90                  95                

ctg aaa atc agc aga gtg gag gct gag gat ttg gga gtt tat tat tgc        336
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys           
            100                 105                 110                   

tgg caa ggt aca cat ttt cct tac acg ttc gga ggg ggg acc aag ctg        384
Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu           
        115                 120                 125                       

gaa ata aaa                                                            393
Glu Ile Lys                                                               
    130                                                                   


<210>  80
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  80

Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Phe Trp Ile Arg Glu 
1               5                   10                  15      


Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val 
            20                  25                  30          


Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  81
<211>  5238
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide pFastBac1

<400>  81
ttctctgtca cagaatgaaa atttttctgt catctcttcg ttattaatgt ttgtaattga       60

ctgaatatca acgcttattt gcagcctgaa tggcgaatgg gacgcgccct gtagcggcgc      120

attaagcgcg gcgggtgtgg tggttacgcg cagcgtgacc gctacacttg ccagcgccct      180

agcgcccgct cctttcgctt tcttcccttc ctttctcgcc acgttcgccg gctttccccg      240

tcaagctcta aatcgggggc tccctttagg gttccgattt agtgctttac ggcacctcga      300

ccccaaaaaa cttgattagg gtgatggttc acgtagtggg ccatcgccct gatagacggt      360

ttttcgccct ttgacgttgg agtccacgtt ctttaatagt ggactcttgt tccaaactgg      420

aacaacactc aaccctatct cggtctattc ttttgattta taagggattt tgccgatttc      480

ggcctattgg ttaaaaaatg agctgattta acaaaaattt aacgcgaatt ttaacaaaat      540

attaacgttt acaatttcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg      600

tttatttttc taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat      660

gcttcaataa tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat      720

tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt      780

aaaagatgct gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag      840

cggtaagatc cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa      900

agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg      960

ccgcatacac tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct     1020

tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac     1080

tgcggccaac ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca     1140

caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat     1200

accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact     1260

attaactggc gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc     1320

ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga     1380

taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg     1440

taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg     1500

aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca     1560

agtttactca tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta     1620

ggtgaagatc ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca     1680

ctgagcgtca gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg     1740

cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga     1800

tcaagagcta ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa     1860

tactgtcctt ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc     1920

tacatacctc gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg     1980

tcttaccggg ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac     2040

ggggggttcg tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct     2100

acagcgtgag cattgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc     2160

ggtaagcggc agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg     2220

gtatctttat agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg     2280

ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct     2340

ggccttttgc tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga     2400

taaccgtatt accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg     2460

cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg cggtattttc tccttacgca     2520

tctgtgcggt atttcacacc gcagaccagc cgcgtaacct ggcaaaatcg gttacggttg     2580

agtaataaat ggatgccctg cgtaagcggg tgtgggcgga caataaagtc ttaaactgaa     2640

caaaatagat ctaaactatg acaataaagt cttaaactag acagaatagt tgtaaactga     2700

aatcagtcca gttatgctgt gaaaaagcat actggacttt tgttatggct aaagcaaact     2760

cttcattttc tgaagtgcaa attgcccgtc gtattaaaga ggggcgtggc caagggcatg     2820

gtaaagacta tattcgcggc gttgtgacaa tttaccgaac aactccgcgg ccgggaagcc     2880

gatctcggct tgaacgaatt gttaggtggc ggtacttggg tcgatatcaa agtgcatcac     2940

ttcttcccgt atgcccaact ttgtatagag agccactgcg ggatcgtcac cgtaatctgc     3000

ttgcacgtag atcacataag caccaagcgc gttggcctca tgcttgagga gattgatgag     3060

cgcggtggca atgccctgcc tccggtgctc gccggagact gcgagatcat agatatagat     3120

ctcactacgc ggctgctcaa acctgggcag aacgtaagcc gcgagagcgc caacaaccgc     3180

ttcttggtcg aaggcagcaa gcgcgatgaa tgtcttacta cggagcaagt tcccgaggta     3240

atcggagtcc ggctgatgtt gggagtaggt ggctacgtct ccgaactcac gaccgaaaag     3300

atcaagagca gcccgcatgg atttgacttg gtcagggccg agcctacatg tgcgaatgat     3360

gcccatactt gagccaccta actttgtttt agggcgactg ccctgctgcg taacatcgtt     3420

gctgctgcgt aacatcgttg ctgctccata acatcaaaca tcgacccacg gcgtaacgcg     3480

cttgctgctt ggatgcccga ggcatagact gtacaaaaaa acagtcataa caagccatga     3540

aaaccgccac tgcgccgtta ccaccgctgc gttcggtcaa ggttctggac cagttgcgtg     3600

agcgcatacg ctacttgcat tacagtttac gaaccgaaca ggcttatgtc aactgggttc     3660

gtgccttcat ccgtttccac ggtgtgcgtc acccggcaac cttgggcagc agcgaagtcg     3720

aggcatttct gtcctggctg gcgaacgagc gcaaggtttc ggtctccacg catcgtcagg     3780

cattggcggc cttgctgttc ttctacggca aggtgctgtg cacggatctg ccctggcttc     3840

aggagatcgg tagacctcgg ccgtcgcggc gcttgccggt ggtgctgacc ccggatgaag     3900

tggttcgcat cctcggtttt ctggaaggcg agcatcgttt gttcgcccag gactctagct     3960

atagttctag tggttggcct acgtacccgt agtggctatg gcagggcttg ccgccccgac     4020

gttggctgcg agccctgggc cttcacccga acttgggggt tggggtgggg aaaaggaaga     4080

aacgcgggcg tattggtccc aatggggtct cggtggggta tcgacagagt gccagccctg     4140

ggaccgaacc ccgcgtttat gaacaaacga cccaacaccc gtgcgtttta ttctgtcttt     4200

ttattgccgt catagcgcgg gttccttccg gtattgtctc cttccgtgtt tcagttagcc     4260

tcccccatct cccggtaccg catgctatgc atcagctgct agcaccatgg ctcgagatcc     4320

cgggtgatca agtcttcgtc gagtgattgt aaataaaatg taatttacag tatagtattt     4380

taattaatat acaaatgatt tgataataat tcttatttaa ctataatata ttgtgttggg     4440

ttgaattaaa ggtccgtata ctccggaata ttaatagatc atggagataa ttaaaatgat     4500

aaccatctcg caaataaata agtattttac tgttttcgta acagttttgt aataaaaaaa     4560

cctataaata ttccggatta ttcataccgt cccaccatcg ggcgcggatc ccggtccgaa     4620

gcgcgcggaa ttcaaaggcc tacgtcgacg agctcactag tcgcggccgc tttcgaatct     4680

agagcctgca gtctcgacaa gcttgtcgag aagtactaga ggatcataat cagccatacc     4740

acatttgtag aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa     4800

cataaaatga atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa     4860

taaagcaata gcatcacaaa tttcacaaat aaagcatttt tttcactgca ttctagttgt     4920

ggtttgtcca aactcatcaa tgtatcttat catgtctgga tctgatcact gcttgagcct     4980

aggagatccg aaccagataa gtgaaatcta gttccaaact attttgtcat ttttaatttt     5040

cgtattagct tacgacgcta cacccagttc ccatctattt tgtcactctt ccctaaataa     5100

tccttaaaaa ctccatttcc acccctccca gttcccaact attttgtccg cccacagcgg     5160

ggcatttttc ttcctgttat gtttttaatc aaacatcctg ccaactccat gtgacaaacc     5220

gtcatcttcg gctacttt                                                   5238


<210>  82
<211>  6442
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide pIIIw


<220>
<221>  misc_feature
<222>  (5086)..(5086)
<223>  n is a, c, g, or t

<400>  82
ccctgcaggg cctgaaataa cctctgaaag aggaacttgg ttaggtacct gtggaatgtg       60

tgtcagttag ggtgtggaaa gtccccaggc tccccagcag gcagaagtat gcaaagcatg      120

catctcaatt agtcagcaac caggtgtgga aagtccccag gctccccagc aggcagaagt      180

atgcaaagca tgcatctcaa ttagtcagca accatagtcc cgcccctaac tccgcccatc      240

ccgcccctaa ctccgcccag ttccgcccat tctccgcccc atggctgact aatttttttt      300

atttatacag aggccgaggc cgcctcggcc tctgagctat tccagaagta gtgaggaggc      360

ttttttggag gcctaggctt ttgcaaaaag cttgattggg atccaccggt cgccaccatg      420

gtgagcaagg gcgaggagct gttcaccggg gtggtgccca tcctggtcga gctggacggc      480

gacgtaaacg gccacaagtt cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc      540

aagctgaccc tgaagttcat ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc      600

gtgaccaccc tgacctacgg cgtgcagtgc ttcagccgct accccgacca catgaagcag      660

cacgacttct tcaagtccgc catgcccgaa ggctacgtcc aggagcgcac catcttcttc      720

aaggacgacg gcaactacaa gacccgcgcc gaggtgaagt tcgagggcga caccctggtg      780

aaccgcatcg agctgaaggg catcgacttc aaggaggacg gcaacatcct ggggcacaag      840

ctggagtaca actacaacag ccacaacgtc tatatcatgg ccgacaagca gaagaacggc      900

atcaaggtga acttcaagat ccgccacaac atcgaggacg gcagcgtgca gctcgccgac      960

cactaccagc agaacacccc catcggcgac ggccccgtgc tgctgcccga caaccactac     1020

ctgagcaccc agtccgccct gagcaaagac cccaacgaga agcgcgatca catggtcctg     1080

ctggagttcg tgaccgccgc cgggatcact ctcggcatgg acgagctgta caagtaaagc     1140

ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa     1200

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca     1260

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc     1320

agggggaggt gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtaaaatcg     1380

ataaggatcc gggctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt     1440

tgcggtggag aagagcatgc gtgaggctcc ggtgcccgtc agtgggcaga gcgcacatcg     1500

cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaaccggtgc ctagagaagg     1560

tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcccttt tcccgagggt     1620

gggggagaac cgtatataag tgcagtagtc gctgtgaacg ttctttttcg caacgggttt     1680

gccgccagaa cacaggtaag tgccgtgtgt ggttcccgcg ggcctggcct ctttacgggt     1740

tatggccctt gcgtgccttg aattacttcc acctggctgc agtacgtgat tcttgatccc     1800

gagcttcggg ttggaagtgg gtgggagagt tcgaggcctt gcgcttaagg agccccttcg     1860

cctcgtgctt gagttgaggc ctggcctggg cgctggggcc gccgcgtgcg aatctggtgg     1920

caccttcgcg cctgtctcgc tgctttcgat aagtctctag ccatttaaaa tttttgatga     1980

cctgctgcga cgcttttttt ctggcaagat agtcttgtaa atgcgggcca agatctgcac     2040

actggtattt cggtttttgg ggccgcgggc ggcgacgggg cccgtgcgtc ccagcgcaca     2100

tgttcggcga ggcggggcct gcgagcgcgg ccaccgagaa tcggacgggg gtagtctcaa     2160

gctggccggc ctgctctggt gcctggcctc gcgccgccgt gtatcgcccc gccctgggcg     2220

gcaaggctgg cccggtcggc accagttgcg tgagcggaaa gatggccgct tcccggccct     2280

gctgcaggga gctcaaaatg gaggacgcgg cgctcgggag agcgggcggg tgagtcaccc     2340

acacaaagga aaagggcctt tccgtcctca gccgtcgctt catgtgactc cacggagtac     2400

cgggcgccgt ccaggcacct cgattagttc tcgagctttt ggagtacgtc gtctttaggt     2460

tggggggagg ggttttatgc gatggagttt ccccacactg agtgggtgga gactgaagtt     2520

aggccagctt ggcacttgat gtaattctcc ttggaatttg ccctttttga gtttggatct     2580

tggttcattc tcaagcctca gacagtggtt caaagttttt ttcttccatt tcaggtgtcg     2640

tgaggaattc tctagagctt gatcaaacaa gtttgtacaa aaaagcaggc tccggagaaa     2700

acctgtattt tcagggcatg gcacccacaa agcgcaaggg cgaatgcccc ggcgccgccc     2760

caaagaaacc caaggagcca gtccaggtcc ccaagttgct gatcaagggc ggcgtggagg     2820

tcctggaggt caagaccggc gtggacgcca tcaccgaggt ggagtgtttc ttgaaccccg     2880

agatgggcga ccccgacgac catctgcgcg ggtacagcca gcacctgacc gccgagaacg     2940

cattcgattc cgactcaccc gataagaaga tgttgccatg ctattccacc gcccgcatcc     3000

cactgcccaa cctcaacgaa gacttgacat gcggcaacct gctgatgtgg gaagccgtca     3060

ccgtgaagac cgaagtcatc ggcatcacct ccatgttgaa tctgcacgcc ggaagccaaa     3120

aggtgcacga gaacggcggc gggaagcccg tccaggggtc aaacttccat ttcttcgccg     3180

tcggcggcga tccactcgag atgcaaggcg tgttgatgaa ctatcgcacc aagtatcccc     3240

aaggcaccat cacacccaag aacccaaccg cccaaagtca ggtcatgaac accgatcaca     3300

aagcatatct cgataagaat aacgcctacc ccgtcgagtg ttggatcccc gatccatcca     3360

agaacgagaa cacccgctac ttcggcacct ataccggcgg cgagaacgtc ccacccgtgt     3420

tgcacgtgac aaataccgcc acaaccgtcc tgctcgacga gcaaggcgtc ggcccactct     3480

gcaaggcaga cagcctctac gtcagcgccg ccgacatctg cggactgttc accaattcaa     3540

gcggcaccca gcaatggcgc gggttggccc gctacttcaa aatcaggctc cgcaagcgca     3600

gcgtgaagaa tccctatcca atcagtttcc tgctgtccga tttgatcaat cgccgcacac     3660

aaaaggtcga cggccagccc atgtacggca tggaaagcca agtcgaagaa gtgcgcgtct     3720

tcgacgggac cgagcagttg cccggcgatc ccgacatgat ccgctacatc gatcgccaag     3780

gccagctcca aaccaagatg gtctgagcct aggacccagc tttcttgtac aaagtggttc     3840

gatctagaat ggctagtgga tcccccgggc tgcaggaatt cgatatcaag cttatcgata     3900

atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac tatgttgctc     3960

cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt gcttcccgta     4020

tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat gaggagttgt     4080

ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca acccccactg     4140

gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc cccctcccta     4200

ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt     4260

tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct tggctgctcg     4320

cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct tcggccctca     4380

atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc     4440

gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat cgataccgtc     4500

ggcccactgc tccctaaacc tgagctagca ttatccctaa tacctgccac cccactctta     4560

atcagtggtg gaagaacggt ctcagaactg tttgtttcaa ttggccattt aagtttagta     4620

gtaaaagact ggttaatgat aacaatgcat cgtaaaacct tcagaaggaa aggagaatgt     4680

tttgtggacc actttggttt tcttttttgc gtgtggcagt tttaagttat tagtttttaa     4740

aatcagtact ttttaatgga aacaacttga ccaaaaattt gtcacagaat tttgagaccc     4800

attaaaaaag ttaaatgaga aacctgtgtg ttcctttggt caacaccgag acatttaggt     4860

gaaagacatc taattctggt tttacgaatc tggaaacttc ttgaaaatgt aattcttgag     4920

ttaacacttc tgggtggaga atagggttgt tttcccccca cataattgga aggggaagga     4980

atatcattta aagctatggg agggtttctt tgattacaac actggagaga aatgcagcat     5040

gttgctgatt gcctgtcact aaaacaggcc aaaaactgag tccttngggt tgcatagaaa     5100

gcttcatgtt gctaaaccaa tgttaagtga atctttggaa acaaaatgtt tccaaattac     5160

tgggatgtgc atgttgaaac gtgggttaat taactagcca tgaccaaaat cccttaacgt     5220

gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat     5280

cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg     5340

gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga     5400

gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac     5460

tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt     5520

ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag     5580

cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc     5640

gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag     5700

gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca     5760

gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt     5820

cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc     5880

tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttcttaat taaatttttc     5940

aaaagtagtt gacaattaat catcggcata gtatatcggc atagtataat acgactcact     6000

ataggagggc catcatggcc aagttgacca gtgctgtccc agtgctcaca gccagggatg     6060

tggctggagc tgttgagttc tggactgaca ggttggggtt ctccagagat tttgtggagg     6120

atgactttgc aggtgtggtc agagatgatg tcaccctgtt catctcagca gtccaggacc     6180

aggtggtgcc tgacaacacc ctggcttggg tgtgggtgag aggactggat gagctgtatg     6240

ctgagtggag tgaggtggtc tccaccaact tcagggatgc cagtggccct gccatgacag     6300

agattggaga gcagccctgg gggagagagt ttgccctgag agacccagca ggcaactgtg     6360

tgcactttgt ggcagaggag caggactgag gataagaatt gtaacaaaaa accccgcccc     6420

ggcggggttt tttgttaatt aa                                              6442


<210>  83
<211>  4242
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide pGL4.10

<400>  83
ggcctaactg gccggtacct gagctcgcta gcctcgagga tatcaagatc tggcctcggc       60

ggccaagctt ggcaatccgg tactgttggt aaagccacca tggaagatgc caaaaacatt      120

aagaagggcc cagcgccatt ctacccactc gaagacggga ccgccggcga gcagctgcac      180

aaagccatga agcgctacgc cctggtgccc ggcaccatcg cctttaccga cgcacatatc      240

gaggtggaca ttacctacgc cgagtacttc gagatgagcg ttcggctggc agaagctatg      300

aagcgctatg ggctgaatac aaaccatcgg atcgtggtgt gcagcgagaa tagcttgcag      360

ttcttcatgc ccgtgttggg tgccctgttc atcggtgtgg ctgtggcccc agctaacgac      420

atctacaacg agcgcgagct gctgaacagc atgggcatca gccagcccac cgtcgtattc      480

gtgagcaaga aagggctgca aaagatcctc aacgtgcaaa agaagctacc gatcatacaa      540

aagatcatca tcatggatag caagaccgac taccagggct tccaaagcat gtacaccttc      600

gtgacttccc atttgccacc cggcttcaac gagtacgact tcgtgcccga gagcttcgac      660

cgggacaaaa ccatcgccct gatcatgaac agtagtggca gtaccggatt gcccaagggc      720

gtagccctac cgcaccgcac cgcttgtgtc cgattcagtc atgcccgcga ccccatcttc      780

ggcaaccaga tcatccccga caccgctatc ctcagcgtgg tgccatttca ccacggcttc      840

ggcatgttca ccacgctggg ctacttgatc tgcggctttc gggtcgtgct catgtaccgc      900

ttcgaggagg agctattctt gcgcagcttg caagactata agattcaatc tgccctgctg      960

gtgcccacac tatttagctt cttcgctaag agcactctca tcgacaagta cgacctaagc     1020

aacttgcacg agatcgccag cggcggggcg ccgctcagca aggaggtagg tgaggccgtg     1080

gccaaacgct tccacctacc aggcatccgc cagggctacg gcctgacaga aacaaccagc     1140

gccattctga tcacccccga aggggacgac aagcctggcg cagtaggcaa ggtggtgccc     1200

ttcttcgagg ctaaggtggt ggacttggac accggtaaga cactgggtgt gaaccagcgc     1260

ggcgagctgt gcgtccgtgg ccccatgatc atgagcggct acgttaacaa ccccgaggct     1320

acaaacgctc tcatcgacaa ggacggctgg ctgcacagcg gcgacatcgc ctactgggac     1380

gaggacgagc acttcttcat cgtggaccgg ctgaagagcc tgatcaaata caagggctac     1440

caggtagccc cagccgaact ggagagcatc ctgctgcaac accccaacat cttcgacgcc     1500

ggggtcgccg gcctgcccga cgacgatgcc ggcgagctgc ccgccgcagt cgtcgtgctg     1560

gaacacggta aaaccatgac cgagaaggag atcgtggact atgtggccag ccaggttaca     1620

accgccaaga agctgcgcgg tggtgttgtg ttcgtggacg aggtgcctaa aggactgacc     1680

ggcaagttgg acgcccgcaa gatccgcgag attctcatta aggccaagaa gggcggcaag     1740

atcgccgtgt aataattcta gagtcggggc ggccggccgc ttcgagcaga catgataaga     1800

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     1860

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     1920

aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttaa     1980

agcaagtaaa acctctacaa atgtggtaaa atcgataagg atccgtcgac cgatgccctt     2040

gagagccttc aacccagtca gctccttccg gtgggcgcgg ggcatgacta tcgtcgccgc     2100

acttatgact gtcttcttta tcatgcaact cgtaggacag gtgccggcag cgctcttccg     2160

cttcctcgct cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc     2220

actcaaaggc ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt     2280

gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc     2340

ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa     2400

acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc     2460

ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg     2520

cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc     2580

tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc     2640

gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca     2700

ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact     2760

acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg     2820

gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt     2880

ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct     2940

tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga     3000

gattatcaaa aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa     3060

tctaaagtat atatgagtaa acttggtctg acagcggccg caaatgctaa accactgcag     3120

tggttaccag tgcttgatca gtgaggcacc gatctcagcg atctgcctat ttcgttcgtc     3180

catagtggcc tgactccccg tcgtgtagat cactacgatt cgtgagggct taccatcagg     3240

ccccagcgca gcaatgatgc cgcgagagcc gcgttcaccg gcccccgatt tgtcagcaat     3300

gaaccagcca gcagggaggg ccgagcgaag aagtggtcct gctactttgt ccgcctccat     3360

ccagtctatg agctgctgtc gtgatgctag agtaagaagt tcgccagtga gtagtttccg     3420

aagagttgtg gccattgcta ctggcatcgt ggtatcacgc tcgtcgttcg gtatggcttc     3480

gttcaactct ggttcccagc ggtcaagccg ggtcacatga tcacccatat tatgaagaaa     3540

tgcagtcagc tccttagggc ctccgatcgt tgtcagaagt aagttggccg cggtgttgtc     3600

gctcatggta atggcagcac tacacaattc tcttaccgtc atgccatccg taagatgctt     3660

ttccgtgacc ggcgagtact caaccaagtc gttttgtgag tagtgtatac ggcgaccaag     3720

ctgctcttgc ccggcgtcta tacgggacaa caccgcgcca catagcagta ctttgaaagt     3780

gctcatcatc gggaatcgtt cttcggggcg gaaagactca aggatcttgc cgctattgag     3840

atccagttcg atatagccca ctcttgcacc cagttgatct tcagcatctt ttactttcac     3900

cagcgtttcg gggtgtgcaa aaacaggcaa gcaaaatgcc gcaaagaagg gaatgagtgc     3960

gacacgaaaa tgttggatgc tcatactcgt cctttttcaa tattattgaa gcatttatca     4020

gggttactag tacgtctctc aaggataagt aagtaatatt aaggtacggg aggtattgga     4080

caggccgcaa taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat     4140

cgatagtact aacatacgct ctccatcaaa acaaaacgaa acaaaacaaa ctagcaaaat     4200

aggctgtccc cagtgcaagt gcaggtgcca gaacatttct ct                        4242


<210>  84
<211>  1065
<212>  DNA
<213>  JC virus


<220>
<221>  CDS
<222>  (1)..(1065)
<223>  Gne VP-1

<400>  84
atg gcc cca aca aaa aga aaa gga gaa agg aag gac ccc gtg caa gtt         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val           
1               5                   10                  15                

cca aaa ctt ctt ata aga gga gga gta gaa gtt cta gaa gtt aaa act         96
Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr           
            20                  25                  30                    

ggg gtt gac tca att aca gag gta gaa tgc ttt tta act cca gaa atg        144
Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met           
        35                  40                  45                        

ggt gac cca gat gag cat ctt agg ggt ttt agt aag tca ata tct ata        192
Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile           
    50                  55                  60                            

tca gat aca ttt gaa agt gac tcc cca aat agg gac atg ctt cct tgt        240
Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Arg Asp Met Leu Pro Cys           
65                  70                  75                  80            

tac agt gtg gcc aga att cca cta ccc aat cta aat gag gat cta acc        288
Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr           
                85                  90                  95                

tgt gga aat ata ctc atg tgg gag gct gtg acc tta aaa act gag gtt        336
Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val           
            100                 105                 110                   

ata ggg gtg aca agt ttg atg aat gtg cac tct aat ggg caa gca act        384
Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr           
        115                 120                 125                       

cat gac aat ggt gca ggg aag cca gtg cag ggc acc agc ttt cat ttt        432
His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe           
    130                 135                 140                           

ttt tct gtt ggg ggg gag gct tta gaa tta cag ggg gtg ctt ttt aat        480
Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Leu Phe Asn           
145                 150                 155                 160           

tac aga aca aag tac cca gat gga aca att ttt cca aag aat gcc aca        528
Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr           
                165                 170                 175               

gtg caa tct caa gtc atg aac aca gag cac aag gcg tac cta gat aag        576
Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys           
            180                 185                 190                   

aac aaa gca tat cct gtt gaa tgt tgg gtt cct gat ccc acc aga aat        624
Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn           
        195                 200                 205                       

gaa aac aca aga tat ttt ggg aca cta aca gga gga gaa aat gtt cct        672
Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro           
    210                 215                 220                           

cca gtt ctt cat ata aca aac act gcc aca aca gtg ttg ctt gat gaa        720
Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu           
225                 230                 235                 240           

ttt ggt gtt ggg cca ctt tgc aaa ggt gac aac tta tac ttg tca gct        768
Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala           
                245                 250                 255               

gtt gat gtc tgt ggc atg ttt aca aac agg tct ggt tcc cag cag tgg        816
Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp           
            260                 265                 270                   

aga gga ctc tcc aga tat ttt aag gtg cag cta agg aaa agg agg gtt        864
Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val           
        275                 280                 285                       

aaa aac ccc tac cca att tct ttc ctt ctt act gat tta att aac aga        912
Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg           
    290                 295                 300                           

agg act cct aga gtt gat ggg cag cct atg tat ggc atg gat gct caa        960
Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln           
305                 310                 315                 320           

gta gag gag gtt aga gtt ttt gag gga aca gag gag ctt cca ggg gac       1008
Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp           
                325                 330                 335               

cca gac atg atg aga tac gtt gac aaa tat gga cag ttg cag aca aaa       1056
Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys           
            340                 345                 350                   

atg ctg taa                                                           1065
Met Leu                                                                   
                                                                          


<210>  85
<211>  354
<212>  PRT
<213>  JC virus

<400>  85

Met Ala Pro Thr Lys Arg Lys Gly Glu Arg Lys Asp Pro Val Gln Val 
1               5                   10                  15      


Pro Lys Leu Leu Ile Arg Gly Gly Val Glu Val Leu Glu Val Lys Thr 
            20                  25                  30          


Gly Val Asp Ser Ile Thr Glu Val Glu Cys Phe Leu Thr Pro Glu Met 
        35                  40                  45              


Gly Asp Pro Asp Glu His Leu Arg Gly Phe Ser Lys Ser Ile Ser Ile 
    50                  55                  60                  


Ser Asp Thr Phe Glu Ser Asp Ser Pro Asn Arg Asp Met Leu Pro Cys 
65                  70                  75                  80  


Tyr Ser Val Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr 
                85                  90                  95      


Cys Gly Asn Ile Leu Met Trp Glu Ala Val Thr Leu Lys Thr Glu Val 
            100                 105                 110         


Ile Gly Val Thr Ser Leu Met Asn Val His Ser Asn Gly Gln Ala Thr 
        115                 120                 125             


His Asp Asn Gly Ala Gly Lys Pro Val Gln Gly Thr Ser Phe His Phe 
    130                 135                 140                 


Phe Ser Val Gly Gly Glu Ala Leu Glu Leu Gln Gly Val Leu Phe Asn 
145                 150                 155                 160 


Tyr Arg Thr Lys Tyr Pro Asp Gly Thr Ile Phe Pro Lys Asn Ala Thr 
                165                 170                 175     


Val Gln Ser Gln Val Met Asn Thr Glu His Lys Ala Tyr Leu Asp Lys 
            180                 185                 190         


Asn Lys Ala Tyr Pro Val Glu Cys Trp Val Pro Asp Pro Thr Arg Asn 
        195                 200                 205             


Glu Asn Thr Arg Tyr Phe Gly Thr Leu Thr Gly Gly Glu Asn Val Pro 
    210                 215                 220                 


Pro Val Leu His Ile Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu 
225                 230                 235                 240 


Phe Gly Val Gly Pro Leu Cys Lys Gly Asp Asn Leu Tyr Leu Ser Ala 
                245                 250                 255     


Val Asp Val Cys Gly Met Phe Thr Asn Arg Ser Gly Ser Gln Gln Trp 
            260                 265                 270         


Arg Gly Leu Ser Arg Tyr Phe Lys Val Gln Leu Arg Lys Arg Arg Val 
        275                 280                 285             


Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Thr Asp Leu Ile Asn Arg 
    290                 295                 300                 


Arg Thr Pro Arg Val Asp Gly Gln Pro Met Tyr Gly Met Asp Ala Gln 
305                 310                 315                 320 


Val Glu Glu Val Arg Val Phe Glu Gly Thr Glu Glu Leu Pro Gly Asp 
                325                 330                 335     


Pro Asp Met Met Arg Tyr Val Asp Lys Tyr Gly Gln Leu Gln Thr Lys 
            340                 345                 350         


Met Leu 
        


<210>  86
<211>  265
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Fragment de la protine VP-1 de srotype Ib et de squence SEQ ID
       NO : 4

<400>  86

Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val Glu 
1               5                   10                  15      


Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asn Glu Asn Leu Arg Gly 
            20                  25                  30          


Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser Pro 
        35                  40                  45              


Glu Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro 
    50                  55                  60                  


Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu Ala 
65                  70                  75                  80  


Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu 
                85                  90                  95      


His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro Ile 
            100                 105                 110         


Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu 
        115                 120                 125             


Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly Thr 
    130                 135                 140                 


Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp 
145                 150                 155                 160 


His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp 
                165                 170                 175     


Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Phe 
            180                 185                 190         


Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala 
        195                 200                 205             


Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala 
    210                 215                 220                 


Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn 
225                 230                 235                 240 


Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile 
                245                 250                 255     


Arg Leu Arg Lys Arg Ser Val Lys Asn 
            260                 265 


<210>  87
<211>  265
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Fragment de la protine VP-1 de srotype II et de squence SEQ ID
       NO : 6

<400>  87

Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val Glu 
1               5                   10                  15      


Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp Asn Leu Arg Gly 
            20                  25                  30          


Tyr Ser Leu Lys Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser Pro 
        35                  40                  45              


Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro 
    50                  55                  60                  


Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu Ala 
65                  70                  75                  80  


Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu 
                85                  90                  95      


His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro Val 
            100                 105                 110         


Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu 
        115                 120                 125             


Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly Thr 
    130                 135                 140                 


Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp 
145                 150                 155                 160 


His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp 
                165                 170                 175     


Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Tyr 
            180                 185                 190         


Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala 
        195                 200                 205             


Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala 
    210                 215                 220                 


Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn 
225                 230                 235                 240 


Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile 
                245                 250                 255     


Arg Leu Arg Lys Arg Ser Val Lys Asn 
            260                 265 


<210>  88
<211>  265
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Fragment de la protine VP-1 de srotype III et de squence SEQ 
       ID NO : 8

<400>  88

Glu Val Leu Glu Val Lys Thr Gly Val Asp Ala Ile Thr Glu Val Glu 
1               5                   10                  15      


Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asp His Leu Arg Gly 
            20                  25                  30          


Tyr Ser Gln His Leu Thr Ala Glu Asn Ala Phe Asp Ser Asp Ser Pro 
        35                  40                  45              


Asp Lys Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro 
    50                  55                  60                  


Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu Ala 
65                  70                  75                  80  


Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu 
                85                  90                  95      


His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro Val 
            100                 105                 110         


Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu 
        115                 120                 125             


Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Gln Gly Thr 
    130                 135                 140                 


Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp 
145                 150                 155                 160 


His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp 
                165                 170                 175     


Ile Pro Asp Pro Ser Lys Asn Glu Asn Thr Arg Tyr Phe Gly Thr Tyr 
            180                 185                 190         


Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala 
        195                 200                 205             


Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala 
    210                 215                 220                 


Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn 
225                 230                 235                 240 


Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile 
                245                 250                 255     


Arg Leu Arg Lys Arg Ser Val Lys Asn 
            260                 265 


<210>  89
<211>  265
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Fragment de la protine VP-1 de srotype IV et de squence SEQ ID
       NO : 10

<400>  89

Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val Glu 
1               5                   10                  15      


Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Asn Asp Leu Arg Gly 
            20                  25                  30          


Tyr Ser Leu Arg Leu Thr Ala Glu Thr Ala Phe Glu Ser Asp Ser Pro 
        35                  40                  45              


Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro 
    50                  55                  60                  


Asn Leu Asn Glu Asp Leu Thr Cys Gly Ser Leu Leu Met Trp Glu Ala 
65                  70                  75                  80  


Val Thr Val Lys Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu 
                85                  90                  95      


His Ala Gly Ser Gln Lys Val His Glu Asn Gly Gly Gly Lys Pro Ile 
            100                 105                 110         


Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu 
        115                 120                 125             


Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly Thr 
    130                 135                 140                 


Val Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp 
145                 150                 155                 160 


His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp 
                165                 170                 175     


Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Tyr 
            180                 185                 190         


Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala 
        195                 200                 205             


Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala 
    210                 215                 220                 


Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn 
225                 230                 235                 240 


Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Pro Arg Tyr Phe Lys Ile 
                245                 250                 255     


Arg Leu Arg Lys Arg Ser Val Lys Asn 
            260                 265 


<210>  90
<211>  1089
<212>  DNA
<213>  BK virus


<220>
<221>  CDS
<222>  (1)..(1089)
<223>  Gne VP-1, srotype Ib2

<400>  90
atg gca ccc aca aag cgc aag ggc gaa tgc ccc ggc gcc gcc cca aag         48
Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys           
1               5                   10                  15                

aaa ccc aag gag cca gtc cag gtc ccc aag ttg ctg atc aag ggc ggc         96
Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly           
            20                  25                  30                    

gtg gag gtc ctg gag gtc aag acc ggc ctg gac gcc atc acc gag gtg        144
Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val           
        35                  40                  45                        

gag tgt ttc ttg aac ccc gag atg ggc gac ccc gac gag aac ctg cgc        192
Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg           
    50                  55                  60                            

ggg ttc agc ttg aag ctg agc gct gag aac gac ttc agc tcc gac tca        240
Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser           
65                  70                  75                  80            

ccc gac cgc aag atg ttg cca tgc tat tcc acc gcc cgc atc cca ctg        288
Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu           
                85                  90                  95                

ccc aac ctc aac gaa gac ttg aca tgc ggc aac ctg ctg atg tgg gaa        336
Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu           
            100                 105                 110                   

gcc gtc acc gtg cag acc gaa gtc atc ggc atc acc tcc atg ttg aat        384
Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn           
        115                 120                 125                       

ctg cac gcc gga agc caa aag gtg cac gag cac ggc ggc ggg aag ccc        432
Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro           
    130                 135                 140                           

atc cag ggg tca aac ttc cat ttc ttc gcc gtc ggc ggc gat cca ctc        480
Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu           
145                 150                 155                 160           

gag atg caa ggc gtg ttg atg aac tat cgc acc aag tat ccc gaa ggc        528
Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly           
                165                 170                 175               

acc atc aca ccc aag aac cca acc gcc caa agt cag gtc atg aac acc        576
Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr           
            180                 185                 190                   

gat cac aaa gca tat ctc gat aag aat aac gcc tac ccc gtc gag tgt        624
Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys           
        195                 200                 205                       

tgg atc ccc gat cca tcc cgg aac gag aac acc cgc tac ttc ggc acc        672
Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr           
    210                 215                 220                           

ttt acc ggc ggc gag aac gtc cca ccc gtg ttg cac gtg aca aat acc        720
Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr           
225                 230                 235                 240           

gcc aca acc gtc ctg ctc gac gag caa ggc gtc ggc cca ctc tgc aag        768
Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys           
                245                 250                 255               

gca gac agc ctc tac gtc agc gcc gcc gac atc tgc gga ctg ttc acc        816
Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr           
            260                 265                 270                   

aat tca agc ggc acc cag caa tgg cgc ggg ttg gcc cgc tac ttc aaa        864
Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys           
        275                 280                 285                       

atc agg ctc cgc aag cgc agc gtg aag aat ccc tat cca atc agt ttc        912
Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe           
    290                 295                 300                           

ctg ctg tcc gat ttg atc aat cgc cgc aca caa cgc gtc gac ggc cag        960
Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln           
305                 310                 315                 320           

ccc atg tac ggc atg gaa agc caa gtc gaa gaa gtg cgc gtc ttc gac       1008
Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp           
                325                 330                 335               

ggg acc gag cgg ttg ccc ggc gat ccc gac atg atc cgc tac atc gat       1056
Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp           
            340                 345                 350                   

aag caa ggc cag ctc caa acc aag atg ctg tga                           1089
Lys Gln Gly Gln Leu Gln Thr Lys Met Leu                                   
        355                 360                                           


<210>  91
<211>  362
<212>  PRT
<213>  BK virus

<400>  91

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  92
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant R93E

<400>  92

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Glu Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  93
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant T192A D193K

<400>  93

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Ala 
            180                 185                 190         


Lys His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  94
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant D199N K200N N201A N202A

<400>  94

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asn Asn Ala Ala Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  95
<211>  357
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant E73_S77del

<400>  95

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Ser Asp Ser Pro Asp Arg Lys Met 
65                  70                  75                  80  


Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro Asn Leu Asn Glu 
                85                  90                  95      


Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu Ala Val Thr Val Gln 
            100                 105                 110         


Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu His Ala Gly Ser 
        115                 120                 125             


Gln Lys Val His Glu His Gly Gly Gly Lys Pro Ile Gln Gly Ser Asn 
    130                 135                 140                 


Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu Met Gln Gly Val 
145                 150                 155                 160 


Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly Thr Ile Thr Pro Lys 
                165                 170                 175     


Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp His Lys Ala Tyr 
            180                 185                 190         


Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp Ile Pro Asp Pro 
        195                 200                 205             


Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Phe Thr Gly Gly Glu 
    210                 215                 220                 


Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala Thr Thr Val Leu 
225                 230                 235                 240 


Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala Asp Ser Leu Tyr 
                245                 250                 255     


Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn Ser Ser Gly Thr 
            260                 265                 270         


Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile Arg Leu Arg Lys 
        275                 280                 285             


Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Ser Asp Leu 
    290                 295                 300                 


Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln Pro Met Tyr Gly Met 
305                 310                 315                 320 


Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp Gly Thr Glu Arg Leu 
                325                 330                 335     


Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp Lys Gln Gly Gln Leu 
            340                 345                 350         


Gln Thr Lys Met Leu 
        355         


<210>  96
<211>  350
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant S71_D82del

<400>  96

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala 
65                  70                  75                  80  


Arg Ile Pro Leu Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu 
                85                  90                  95      


Leu Met Trp Glu Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr 
            100                 105                 110         


Ser Met Leu Asn Leu His Ala Gly Ser Gln Lys Val His Glu His Gly 
        115                 120                 125             


Gly Gly Lys Pro Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly 
    130                 135                 140                 


Gly Asp Pro Leu Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys 
145                 150                 155                 160 


Tyr Pro Glu Gly Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln 
                165                 170                 175     


Val Met Asn Thr Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr 
            180                 185                 190         


Pro Val Glu Cys Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg 
        195                 200                 205             


Tyr Phe Gly Thr Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His 
    210                 215                 220                 


Val Thr Asn Thr Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly 
225                 230                 235                 240 


Pro Leu Cys Lys Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys 
                245                 250                 255     


Gly Leu Phe Thr Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala 
            260                 265                 270         


Arg Tyr Phe Lys Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr 
        275                 280                 285             


Pro Ile Ser Phe Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg 
    290                 295                 300                 


Val Asp Gly Gln Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val 
305                 310                 315                 320 


Arg Val Phe Asp Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile 
                325                 330                 335     


Arg Tyr Ile Asp Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
            340                 345                 350 


<210>  97
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant K135A E138A H139A

<400>  97

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Ala Val His Ala Ala Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  98
<211>  357
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant K135_H139del

<400>  98

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Gly Gly Gly Lys Pro Ile Gln Gly Ser Asn 
    130                 135                 140                 


Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu Met Gln Gly Val 
145                 150                 155                 160 


Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly Thr Ile Thr Pro Lys 
                165                 170                 175     


Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp His Lys Ala Tyr 
            180                 185                 190         


Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp Ile Pro Asp Pro 
        195                 200                 205             


Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Phe Thr Gly Gly Glu 
    210                 215                 220                 


Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala Thr Thr Val Leu 
225                 230                 235                 240 


Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala Asp Ser Leu Tyr 
                245                 250                 255     


Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn Ser Ser Gly Thr 
            260                 265                 270         


Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile Arg Leu Arg Lys 
        275                 280                 285             


Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Ser Asp Leu 
    290                 295                 300                 


Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln Pro Met Tyr Gly Met 
305                 310                 315                 320 


Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp Gly Thr Glu Arg Leu 
                325                 330                 335     


Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp Lys Gln Gly Gln Leu 
            340                 345                 350         


Gln Thr Lys Met Leu 
        355         


<210>  99
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant S274A S275A

<400>  99

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ala Ala Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  100
<211>  358
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant S274_T277del

<400>  100

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Arg Lys Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile Arg Leu Arg 
        275                 280                 285             


Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Ser Asp 
    290                 295                 300                 


Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln Pro Met Tyr Gly 
305                 310                 315                 320 


Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp Gly Thr Glu Arg 
                325                 330                 335     


Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp Lys Gln Gly Gln 
            340                 345                 350         


Leu Gln Thr Lys Met Leu 
        355             


<210>  101
<211>  362
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant R83A K84A

<400>  101

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Ala Ala Met Leu Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu 
                85                  90                  95      


Pro Asn Leu Asn Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu 
            100                 105                 110         


Ala Val Thr Val Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn 
        115                 120                 125             


Leu His Ala Gly Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro 
    130                 135                 140                 


Ile Gln Gly Ser Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu 
145                 150                 155                 160 


Glu Met Gln Gly Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly 
                165                 170                 175     


Thr Ile Thr Pro Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr 
            180                 185                 190         


Asp His Lys Ala Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys 
        195                 200                 205             


Trp Ile Pro Asp Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr 
    210                 215                 220                 


Phe Thr Gly Gly Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr 
225                 230                 235                 240 


Ala Thr Thr Val Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys 
                245                 250                 255     


Ala Asp Ser Leu Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr 
            260                 265                 270         


Asn Ser Ser Gly Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys 
        275                 280                 285             


Ile Arg Leu Arg Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe 
    290                 295                 300                 


Leu Leu Ser Asp Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln 
305                 310                 315                 320 


Pro Met Tyr Gly Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp 
                325                 330                 335     


Gly Thr Glu Arg Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp 
            340                 345                 350         


Lys Gln Gly Gln Leu Gln Thr Lys Met Leu 
        355                 360         


<210>  102
<211>  358
<212>  PRT
<213>  BK virus


<220>
<221>  misc_feature
<223>  Protine VP-1 srotype Ib2, mutant R83_L86del

<400>  102

Met Ala Pro Thr Lys Arg Lys Gly Glu Cys Pro Gly Ala Ala Pro Lys 
1               5                   10                  15      


Lys Pro Lys Glu Pro Val Gln Val Pro Lys Leu Leu Ile Lys Gly Gly 
            20                  25                  30          


Val Glu Val Leu Glu Val Lys Thr Gly Leu Asp Ala Ile Thr Glu Val 
        35                  40                  45              


Glu Cys Phe Leu Asn Pro Glu Met Gly Asp Pro Asp Glu Asn Leu Arg 
    50                  55                  60                  


Gly Phe Ser Leu Lys Leu Ser Ala Glu Asn Asp Phe Ser Ser Asp Ser 
65                  70                  75                  80  


Pro Asp Pro Cys Tyr Ser Thr Ala Arg Ile Pro Leu Pro Asn Leu Asn 
                85                  90                  95      


Glu Asp Leu Thr Cys Gly Asn Leu Leu Met Trp Glu Ala Val Thr Val 
            100                 105                 110         


Gln Thr Glu Val Ile Gly Ile Thr Ser Met Leu Asn Leu His Ala Gly 
        115                 120                 125             


Ser Gln Lys Val His Glu His Gly Gly Gly Lys Pro Ile Gln Gly Ser 
    130                 135                 140                 


Asn Phe His Phe Phe Ala Val Gly Gly Asp Pro Leu Glu Met Gln Gly 
145                 150                 155                 160 


Val Leu Met Asn Tyr Arg Thr Lys Tyr Pro Glu Gly Thr Ile Thr Pro 
                165                 170                 175     


Lys Asn Pro Thr Ala Gln Ser Gln Val Met Asn Thr Asp His Lys Ala 
            180                 185                 190         


Tyr Leu Asp Lys Asn Asn Ala Tyr Pro Val Glu Cys Trp Ile Pro Asp 
        195                 200                 205             


Pro Ser Arg Asn Glu Asn Thr Arg Tyr Phe Gly Thr Phe Thr Gly Gly 
    210                 215                 220                 


Glu Asn Val Pro Pro Val Leu His Val Thr Asn Thr Ala Thr Thr Val 
225                 230                 235                 240 


Leu Leu Asp Glu Gln Gly Val Gly Pro Leu Cys Lys Ala Asp Ser Leu 
                245                 250                 255     


Tyr Val Ser Ala Ala Asp Ile Cys Gly Leu Phe Thr Asn Ser Ser Gly 
            260                 265                 270         


Thr Gln Gln Trp Arg Gly Leu Ala Arg Tyr Phe Lys Ile Arg Leu Arg 
        275                 280                 285             


Lys Arg Ser Val Lys Asn Pro Tyr Pro Ile Ser Phe Leu Leu Ser Asp 
    290                 295                 300                 


Leu Ile Asn Arg Arg Thr Gln Arg Val Asp Gly Gln Pro Met Tyr Gly 
305                 310                 315                 320 


Met Glu Ser Gln Val Glu Glu Val Arg Val Phe Asp Gly Thr Glu Arg 
                325                 330                 335     


Leu Pro Gly Asp Pro Asp Met Ile Arg Tyr Ile Asp Lys Gln Gly Gln 
            340                 345                 350         


Leu Gln Thr Lys Met Leu 
        355             


