                         SEQUENCE LISTING

<110>  FUNDACI INSTITUT D'INVESTIGACIO BIOMDICA DE BELLVITGE  
       (IDIBELL)
       FUNDACIN ALBA PREZ, LUCHA CONTRA EL CNCER INFANTIL 
       (FUNDACION ALBA PREZ)
 
<120>  EPH2A APTAMER AND USES THEREOF

<130>  P5471PC00

<150>  EP19382451.3
<151>  2019-06-03

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer

<400>  1
gucgucuugc guccccagac gacuc                                             25


<210>  2
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Aptamer

<400>  2
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg a                51


<210>  3
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified aptamer


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  all pyrimidines are 2-fluoro

<400>  3
gucgucuugc guccccagac gacuc                                             25


<210>  4
<211>  51
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified aptamer


<220>
<221>  misc_feature
<222>  (1)..(51)
<223>  all pyrimidines are 2-fluoro

<400>  4
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg a                51


<210>  5
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  5
cgggcagcag aacccuucuu augac                                             25


<210>  6
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  6
auggccucuc accucagaau ucaau                                             25


<210>  7
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  7
ugcccaagaa gccagcagag gaauu                                             25


<210>  8
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified siRNA


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  all pyrimidines are 2-fluoro

<400>  8
cgggcagcag aacccuucuu augac                                             25


<210>  9
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified siRNA


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  all pyrimidines are 2-fluoro

<400>  9
auggccucuc accucagaau ucaau                                             25


<210>  10
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified siRNA


<220>
<221>  misc_feature
<222>  (1)..(25)
<223>  all pyrimidines are 2-fluoro

<400>  10
ugcccaagaa gccagcagag gaauu                                             25


<210>  11
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  11
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuucgggca       60

gcagaacccu ucuuaugacu u                                                 81


<210>  12
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  12
gucgucuugc guccccagac gacucuuucg ggcagcagaa cccuucuuau gacuu            55


<210>  13
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  13
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuuauggcc       60

ucucaccuca gaauucaauu u                                                 81


<210>  14
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  14
gucgucuugc guccccagac gacucuuuau ggccucucac cucagaauuc aauuu            55


<210>  15
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  15
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuuugccca       60

agaagccagc agaggaauuu u                                                 81


<210>  16
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Complex aptamer-siRNA

<400>  16
gucgucuugc guccccagac gacucuuuug cccaagaagc cagcagagga auuuu            55


<210>  17
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(79)
<223>  all pyrimidines are 2-fluoro, except at positions 52-54

<400>  17
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuucgggca       60

gcagaacccu ucuuaugacu u                                                 81


<210>  18
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  all pyrimidines are 2-fluoro, except at positions 26-28

<400>  18
gucgucuugc guccccagac gacucuuucg ggcagcagaa cccuucuuau gacuu            55


<210>  19
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(79)
<223>  all pyrimidines are 2-fluoro, except at positions 52-54

<400>  19
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuuauggcc       60

ucucaccuca gaauucaauu u                                                 81


<210>  20
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  all pyrimidines are 2-fluoro, except at positions 26-28

<400>  20
gucgucuugc guccccagac gacucuuuau ggccucucac cucagaauuc aauuu            55


<210>  21
<211>  81
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(79)
<223>  all pyrimidines are 2-fluoro, except at positions 52-54

<400>  21
gggaggacga ugcgguccuu gucgucuugc guccccagac gacucgcccg auuuugccca       60

agaagccagc agaggaauuu u                                                 81


<210>  22
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Modified complex aptamer-siRNA


<220>
<221>  misc_feature
<222>  (1)..(53)
<223>  all pyrimidines are 2-fluoro, except at positions 26-28

<400>  22
gucgucuugc guccccagac gacucuuuug cccaagaagc cagcagagga auuuu            55


<210>  23
<211>  60
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  RNA library variable region


<220>
<221>  misc_feature
<222>  (15)..(44)
<223>  n is a, c, g, or u

<400>  23
ggaggacgau gcggnnnnnn nnnnnnnnnn nnnnnnnnnn nnnncagacg acucgcccga       60


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sel2 5' primer

<400>  24
taatacgact cactataggg aggacgatgc gg                                     32


<210>  25
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sel2 3' primer

<400>  25
tcgggcgagt cgtctg                                                       16


<210>  26
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sel1 5' primer

<400>  26
gggggaattc taatacgact cactataggg agagaggaag agggatggg                   49


<210>  27
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sel 1 3' primer

<400>  27
ggggggatcc agtactatcg acctctgggt tatg                                   34


