                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Ares Trading S.A.
       ALIMZHANOV, Marat
       CHING, Keith Anthony
       DI PIETRO, Alessandra
       MU, Xinmeng
       ROBBINS, Paul Brian
 
<120>  PD-1 AXIS BINDING ANTAGONIST TO TREAT CANCER

<130>  PC72521A

<150>  US 63/013,132
<151>  2020-04-21

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Gln Val Gln Leu 
        435                 440                 1               


Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val 
5                   10                  15                  20  


Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn Trp 
                25                  30                  35      


Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Asn Ile Tyr 
            40                  45                  50          


Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe Lys Asn Arg Val 
        55                  60                  65              


Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu Leu Ser 
    70                  75                  80                  


Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Ser 
85                  90                  95                  100 


Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                105                 110                 115     


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
            120                 125                 130         


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
        135                 140                 145             


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
    150                 155                 160                 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
165                 170                 175                 180 


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
                185                 190                 195     


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
            200                 205                 210         


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
        215                 220                 225             


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    230                 235                 240                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
245                 250                 255                 260 


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
                265                 270                 275     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            280                 285                 290         


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        295                 300                 305             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
    310                 315                 320                 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
325                 330                 335                 340 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
                345                 350                 355     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            360                 365                 370         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        375                 380                 385             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    390                 395                 400                 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
405                 410                 415                 420 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                425                 430                 435     


Ser Leu Ser Leu Ser Leu Gly Lys 
            440                 


<210>  2
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  3
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Gly Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
        115                 120                 125             


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
    130                 135                 140                 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
145                 150                 155                 160 


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
                165                 170                 175     


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
            180                 185                 190         


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
        195                 200                 205             


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220     


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu 
    1               5                   10                  15  


Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp 
                20                  25                  30      


Ser Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly 
            35                  40                  45          


Gln Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly 
        50                  55                  60              


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
    65                  70                  75                  


Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln 
80                  85                  90                  95  


Asn Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu 
                100                 105                 110     


Ile Lys 
        


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Trp Pro Gly Ser Ser Leu Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Thr Gly Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Trp Asp Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Phe Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Thr Ser Tyr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Phe Tyr Pro His Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Trp Gln Pro Gly Arg Ser 
1               5                   10                  15      


Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser Gly 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
        35                  40                  45              


Val Arg Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Thr Tyr Thr 
            180                 185                 190         


Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Arg Val Glu 
        195                 200                 205             


Ser Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
    210                 215                 220                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Trp Val Asp Val Ser Gln Glu 
                245                 250                 255     


Asp Pro Glu Val Gln Phe Asn Trp Tyr Tyr Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        275                 280                 285             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    290                 295                 300                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Lys Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            420                 425                 430         


<210>  8
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
        35                  40                  45              


Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Arg Thr Val Ala Ala Pro Ser 
            100                 105                 110         


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Ser Gly Thr Ala Ser 
        115                 120                 125             


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
                165                 170                 175     


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
            180                 185                 190         


His Gln Gly Leu Ser Ser Pro Val Thr Ser Phe Asn Arg Gly Glu Cys 
        195                 200                 205             


<210>  9
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  10
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  11
<211>  432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile Glu His Gly 
1               5                   10                  15      


Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser His Val Asn 
            20                  25                  30          


Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn Asp Thr Ser 
        35                  40                  45              


Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu Pro Leu Gly 
    50                  55                  60                  


Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp Glu Gly Gln 
65                  70                  75                  80  


Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr Lys Tyr Leu 
                85                  90                  95      


Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr His Ile Leu 
            100                 105                 110         


Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln Ala Thr Gly 
        115                 120                 125             


Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val Pro Ala Asn 
    130                 135                 140                 


Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val Thr Ser Val 
145                 150                 155                 160 


Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys Val Phe Trp 
                165                 170                 175     


Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp Leu Gln Ser 
            180                 185                 190         


Gln Met Glu Pro Arg Thr His Pro Thr Trp Glu Pro Lys Ser Cys Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Trp Val Asp Val Ser His Glu Asp 
                245                 250                 255     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            260                 265                 270         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Trp 
        275                 280                 285             


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
    290                 295                 300                 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
305                 310                 315                 320 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
                325                 330                 335     


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
            340                 345                 350         


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
        355                 360                 365             


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
    370                 375                 380                 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
385                 390                 395                 400 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
                405                 410                 415     


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            420                 425                 430         


<210>  12
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
65                  70                  75                  80  


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ile 
                85                  90                  95      


Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  15
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  16
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Ser Tyr Ile Met Met 
1               5   


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr 
1               5                   10      


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr 
1               5                   10      


<210>  20
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Asp Val Ser Asn Arg Pro Ser 
1               5           


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  23
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Lys Leu Gly Thr Val Thr Thr Val Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  24
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Asp Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Arg Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  25
<211>  1453
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Met Leu Pro Gln Asn Ser Trp His Ile Asp Phe Gly Arg Cys Cys 
1               5                   10                  15      


Cys His Gln Asn Leu Phe Ser Ala Val Val Thr Cys Ile Leu Leu Leu 
            20                  25                  30          


Asn Ser Cys Phe Leu Ile Ser Ser Phe Asn Gly Thr Asp Leu Glu Leu 
        35                  40                  45              


Arg Leu Val Asn Gly Asp Gly Pro Cys Ser Gly Thr Val Glu Val Lys 
    50                  55                  60                  


Phe Gln Gly Gln Trp Gly Thr Val Cys Asp Asp Gly Trp Asn Thr Thr 
65                  70                  75                  80  


Ala Ser Thr Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Phe Ala 
                85                  90                  95      


Met Phe Arg Phe Gly Gln Ala Val Thr Arg His Gly Lys Ile Trp Leu 
            100                 105                 110         


Asp Asp Val Ser Cys Tyr Gly Asn Glu Ser Ala Leu Trp Glu Cys Gln 
        115                 120                 125             


His Arg Glu Trp Gly Ser His Asn Cys Tyr His Gly Glu Asp Val Gly 
    130                 135                 140                 


Val Asn Cys Tyr Gly Glu Ala Asn Leu Gly Leu Arg Leu Val Asp Gly 
145                 150                 155                 160 


Asn Asn Ser Cys Ser Gly Arg Val Glu Val Lys Phe Gln Glu Arg Trp 
                165                 170                 175     


Gly Thr Ile Cys Asp Asp Gly Trp Asn Leu Asn Thr Ala Ala Val Val 
            180                 185                 190         


Cys Arg Gln Leu Gly Cys Pro Ser Ser Phe Ile Ser Ser Gly Val Val 
        195                 200                 205             


Asn Ser Pro Ala Val Leu Arg Pro Ile Trp Leu Asp Asp Ile Leu Cys 
    210                 215                 220                 


Gln Gly Asn Glu Leu Ala Leu Trp Asn Cys Arg His Arg Gly Trp Gly 
225                 230                 235                 240 


Asn His Asp Cys Ser His Asn Glu Asp Val Thr Leu Thr Cys Tyr Asp 
                245                 250                 255     


Ser Ser Asp Leu Glu Leu Arg Leu Val Gly Gly Thr Asn Arg Cys Met 
            260                 265                 270         


Gly Arg Val Glu Leu Lys Ile Gln Gly Arg Trp Gly Thr Val Cys His 
        275                 280                 285             


His Lys Trp Asn Asn Ala Ala Ala Asp Val Val Cys Lys Gln Leu Gly 
    290                 295                 300                 


Cys Gly Thr Ala Leu His Phe Ala Gly Leu Pro His Leu Gln Ser Gly 
305                 310                 315                 320 


Ser Asp Val Val Trp Leu Asp Gly Val Ser Cys Ser Gly Asn Glu Ser 
                325                 330                 335     


Phe Leu Trp Asp Cys Arg His Ser Gly Thr Val Asn Phe Asp Cys Leu 
            340                 345                 350         


His Gln Asn Asp Val Ser Val Ile Cys Ser Asp Gly Ala Asp Leu Glu 
        355                 360                 365             


Leu Arg Leu Ala Asp Gly Ser Asn Asn Cys Ser Gly Arg Val Glu Val 
    370                 375                 380                 


Arg Ile His Glu Gln Trp Trp Thr Ile Cys Asp Gln Asn Trp Lys Asn 
385                 390                 395                 400 


Glu Gln Ala Leu Val Val Cys Lys Gln Leu Gly Cys Pro Phe Ser Val 
                405                 410                 415     


Phe Gly Ser Arg Arg Ala Lys Pro Ser Asn Glu Ala Arg Asp Ile Trp 
            420                 425                 430         


Ile Asn Ser Ile Ser Cys Thr Gly Asn Glu Ser Ala Leu Trp Asp Cys 
        435                 440                 445             


Thr Tyr Asp Gly Lys Ala Lys Arg Thr Cys Phe Arg Arg Ser Asp Ala 
    450                 455                 460                 


Gly Val Ile Cys Ser Asp Lys Ala Asp Leu Asp Leu Arg Leu Val Gly 
465                 470                 475                 480 


Ala His Ser Pro Cys Tyr Gly Arg Leu Glu Val Lys Tyr Gln Gly Glu 
                485                 490                 495     


Trp Gly Thr Val Cys His Asp Arg Trp Ser Thr Arg Asn Ala Ala Val 
            500                 505                 510         


Val Cys Lys Gln Leu Gly Cys Gly Lys Pro Leu His Val Phe Gly Met 
        515                 520                 525             


Thr Tyr Phe Lys Glu Ala Ser Gly Pro Ile Trp Leu Asp Asp Val Ser 
    530                 535                 540                 


Cys Ile Gly Asn Glu Ser Asn Ile Trp Asp Cys Glu His Ser Gly Trp 
545                 550                 555                 560 


Gly Lys His Asn Cys Val His Arg Glu Asp Val Ile Val Thr Cys Ser 
                565                 570                 575     


Gly Asp Ala Thr Trp Gly Leu Arg Leu Val Gly Gly Ser Asn Arg Cys 
            580                 585                 590         


Ser Gly Arg Leu Glu Val Tyr Phe Gln Gly Arg Trp Gly Thr Val Cys 
        595                 600                 605             


Asp Asp Gly Trp Asn Ser Lys Ala Ala Ala Val Val Cys Ser Gln Leu 
    610                 615                 620                 


Asp Cys Pro Ser Ser Ile Ile Gly Met Gly Leu Gly Asn Ala Ser Thr 
625                 630                 635                 640 


Gly Tyr Gly Lys Ile Trp Leu Asp Asp Val Ser Cys Asp Gly Asp Glu 
                645                 650                 655     


Ser Asp Leu Trp Ser Cys Arg Asn Ser Gly Trp Gly Asn Asn Asp Cys 
            660                 665                 670         


Ser His Ser Glu Asp Val Gly Val Ile Cys Ser Asp Ala Ser Asp Met 
        675                 680                 685             


Glu Leu Arg Leu Val Gly Gly Ser Ser Arg Cys Ala Gly Lys Val Glu 
    690                 695                 700                 


Val Asn Val Gln Gly Ala Val Gly Ile Leu Cys Ala Asn Gly Trp Gly 
705                 710                 715                 720 


Met Asn Ile Ala Glu Val Val Cys Arg Gln Leu Glu Cys Gly Ser Ala 
                725                 730                 735     


Ile Arg Val Ser Arg Glu Pro His Phe Thr Glu Arg Thr Leu His Ile 
            740                 745                 750         


Leu Met Ser Asn Ser Gly Cys Thr Gly Gly Glu Ala Ser Leu Trp Asp 
        755                 760                 765             


Cys Ile Arg Trp Glu Trp Lys Gln Thr Ala Cys His Leu Asn Met Glu 
    770                 775                 780                 


Ala Ser Leu Ile Cys Ser Ala His Arg Gln Pro Arg Leu Val Gly Ala 
785                 790                 795                 800 


Asp Met Pro Cys Ser Gly Arg Val Glu Val Lys His Ala Asp Thr Trp 
                805                 810                 815     


Arg Ser Val Cys Asp Ser Asp Phe Ser Leu His Ala Ala Asn Val Leu 
            820                 825                 830         


Cys Arg Glu Leu Asn Cys Gly Asp Ala Ile Ser Leu Ser Val Gly Asp 
        835                 840                 845             


His Phe Gly Lys Gly Asn Gly Leu Thr Trp Ala Glu Lys Phe Gln Cys 
    850                 855                 860                 


Glu Gly Ser Glu Thr His Leu Ala Leu Cys Pro Ile Val Gln His Pro 
865                 870                 875                 880 


Glu Asp Thr Cys Ile His Ser Arg Glu Val Gly Val Val Cys Ser Arg 
                885                 890                 895     


Tyr Thr Asp Val Arg Leu Val Asn Gly Lys Ser Gln Cys Asp Gly Gln 
            900                 905                 910         


Val Glu Ile Asn Val Leu Gly His Trp Gly Ser Leu Cys Asp Thr His 
        915                 920                 925             


Trp Asp Pro Glu Asp Ala Arg Val Leu Cys Arg Gln Leu Ser Cys Gly 
    930                 935                 940                 


Thr Ala Leu Ser Thr Thr Gly Gly Lys Tyr Ile Gly Glu Arg Ser Val 
945                 950                 955                 960 


Arg Val Trp Gly His Arg Phe His Cys Leu Gly Asn Glu Ser Leu Leu 
                965                 970                 975     


Asp Asn Cys Gln Met Thr Val Leu Gly Ala Pro Pro Cys Ile His Gly 
            980                 985                 990         


Asn Thr Val Ser Val Ile Cys Thr  Gly Ser Leu Thr Gln  Pro Leu Phe 
        995                 1000                 1005             


Pro Cys  Leu Ala Asn Val Ser  Asp Pro Tyr Leu Ser  Ala Val Pro 
    1010                 1015                 1020             


Glu Gly  Ser Ala Leu Ile Cys  Leu Glu Asp Lys Arg  Leu Arg Leu 
    1025                 1030                 1035             


Val Asp  Gly Asp Ser Arg Cys  Ala Gly Arg Val Glu  Ile Tyr His 
    1040                 1045                 1050             


Asp Gly  Phe Trp Gly Thr Ile  Cys Asp Asp Gly Trp  Asp Leu Ser 
    1055                 1060                 1065             


Asp Ala  His Val Val Cys Gln  Lys Leu Gly Cys Gly  Val Ala Phe 
    1070                 1075                 1080             


Asn Ala  Thr Val Ser Ala His  Phe Gly Glu Gly Ser  Gly Pro Ile 
    1085                 1090                 1095             


Trp Leu  Asp Asp Leu Asn Cys  Thr Gly Met Glu Ser  His Leu Trp 
    1100                 1105                 1110             


Gln Cys  Pro Ser Arg Gly Trp  Gly Gln His Asp Cys  Arg His Lys 
    1115                 1120                 1125             


Glu Asp  Ala Gly Val Ile Cys  Ser Glu Phe Thr Ala  Leu Arg Leu 
    1130                 1135                 1140             


Tyr Ser  Glu Thr Glu Thr Glu  Ser Cys Ala Gly Arg  Leu Glu Val 
    1145                 1150                 1155             


Phe Tyr  Asn Gly Thr Trp Gly  Ser Val Gly Arg Arg  Asn Ile Thr 
    1160                 1165                 1170             


Thr Ala  Ile Ala Gly Ile Val  Cys Arg Gln Leu Gly  Cys Gly Glu 
    1175                 1180                 1185             


Asn Gly  Val Val Ser Leu Ala  Pro Leu Ser Lys Thr  Gly Ser Gly 
    1190                 1195                 1200             


Phe Met  Trp Val Asp Asp Ile  Gln Cys Pro Lys Thr  His Ile Ser 
    1205                 1210                 1215             


Ile Trp  Gln Cys Leu Ser Ala  Pro Trp Glu Arg Arg  Ile Ser Ser 
    1220                 1225                 1230             


Pro Ala  Glu Glu Thr Trp Ile  Thr Cys Glu Asp Arg  Ile Arg Val 
    1235                 1240                 1245             


Arg Gly  Gly Asp Thr Glu Cys  Ser Gly Arg Val Glu  Ile Trp His 
    1250                 1255                 1260             


Ala Gly  Ser Trp Gly Thr Val  Cys Asp Asp Ser Trp  Asp Leu Ala 
    1265                 1270                 1275             


Glu Ala  Glu Val Val Cys Gln  Gln Leu Gly Cys Gly  Ser Ala Leu 
    1280                 1285                 1290             


Ala Ala  Leu Arg Asp Ala Ser  Phe Gly Gln Gly Thr  Gly Thr Ile 
    1295                 1300                 1305             


Trp Leu  Asp Asp Met Arg Cys  Lys Gly Asn Glu Ser  Phe Leu Trp 
    1310                 1315                 1320             


Asp Cys  His Ala Lys Pro Trp  Gly Gln Ser Asp Cys  Gly His Lys 
    1325                 1330                 1335             


Glu Asp  Ala Gly Val Arg Cys  Ser Gly Gln Ser Leu  Lys Ser Leu 
    1340                 1345                 1350             


Asn Ala  Ser Ser Gly His Leu  Ala Leu Ile Leu Ser  Ser Ile Phe 
    1355                 1360                 1365             


Gly Leu  Leu Leu Leu Val Leu  Phe Ile Leu Phe Leu  Thr Trp Cys 
    1370                 1375                 1380             


Arg Val  Gln Lys Gln Lys His  Leu Pro Leu Arg Val  Ser Thr Arg 
    1385                 1390                 1395             


Arg Arg  Gly Ser Leu Glu Glu  Asn Leu Phe His Glu  Met Glu Thr 
    1400                 1405                 1410             


Cys Leu  Lys Arg Glu Asp Pro  His Gly Thr Arg Thr  Ser Asp Asp 
    1415                 1420                 1425             


Thr Pro  Asn His Gly Cys Glu  Asp Ala Ser Asp Thr  Ser Leu Leu 
    1430                 1435                 1440             


Gly Val  Leu Pro Ala Ser Glu  Ala Thr Lys 
    1445                 1450             


<210>  26
<211>  1632
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Thr Leu Ala Val Pro 
1               5                   10                  15      


Ala Ile Ser Leu Pro Asp Asp Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Ser Leu Thr Glu Lys Glu Cys Val Lys Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Asn Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu Arg Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Ala 
                85                  90                  95      


His Ala Tyr Asn Arg Glu Val Asn Gly Arg Leu Glu Asn Gly Asn Gln 
            100                 105                 110         


Ala Arg Ser Glu Ala Arg Arg Val Gly Met Ala Asp Ala Asn Ser Pro 
        115                 120                 125             


Pro Lys Pro Leu Ser Lys Pro Arg Thr Pro Arg Arg Ser Lys Ser Asp 
    130                 135                 140                 


Gly Glu Ala Lys Arg Ser Arg Asp Pro Pro Ala Ser Ala Ser Gln Val 
145                 150                 155                 160 


Thr Gly Ile Arg Ala Glu Pro Ser Pro Ser Pro Arg Ile Thr Arg Lys 
                165                 170                 175     


Ser Thr Arg Gln Thr Thr Ile Thr Ser His Phe Ala Lys Gly Pro Ala 
            180                 185                 190         


Lys Arg Lys Pro Gln Glu Glu Ser Glu Arg Ala Lys Ser Asp Glu Ser 
        195                 200                 205             


Ile Lys Glu Glu Asp Lys Asp Gln Asp Glu Lys Arg Arg Arg Val Thr 
    210                 215                 220                 


Ser Arg Glu Arg Val Ala Arg Pro Leu Pro Ala Glu Glu Pro Glu Arg 
225                 230                 235                 240 


Ala Lys Ser Gly Thr Arg Thr Glu Lys Glu Glu Glu Arg Asp Glu Lys 
                245                 250                 255     


Glu Glu Lys Arg Leu Arg Ser Gln Thr Lys Glu Pro Thr Pro Lys Gln 
            260                 265                 270         


Lys Leu Lys Glu Glu Pro Asp Arg Glu Ala Arg Ala Gly Val Gln Ala 
        275                 280                 285             


Asp Glu Asp Glu Asp Gly Asp Glu Lys Asp Glu Lys Lys His Arg Ser 
    290                 295                 300                 


Gln Pro Lys Asp Leu Ala Ala Lys Arg Arg Pro Glu Glu Lys Glu Pro 
305                 310                 315                 320 


Glu Lys Val Asn Pro Gln Ile Ser Asp Glu Lys Asp Glu Asp Glu Lys 
                325                 330                 335     


Glu Glu Lys Arg Arg Lys Thr Thr Pro Lys Glu Pro Thr Glu Lys Lys 
            340                 345                 350         


Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys 
        355                 360                 365             


Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly 
    370                 375                 380                 


Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu 
385                 390                 395                 400 


Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu 
                405                 410                 415     


Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His 
            420                 425                 430         


Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu 
        435                 440                 445             


Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser 
    450                 455                 460                 


Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp 
465                 470                 475                 480 


Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser 
                485                 490                 495     


Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala 
            500                 505                 510         


Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val 
        515                 520                 525             


Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile 
    530                 535                 540                 


Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg 
545                 550                 555                 560 


Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln 
                565                 570                 575     


Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe 
            580                 585                 590         


Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu 
        595                 600                 605             


Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr 
    610                 615                 620                 


Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val 
625                 630                 635                 640 


Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp 
                645                 650                 655     


Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys 
            660                 665                 670         


Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp 
        675                 680                 685             


Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu 
    690                 695                 700                 


Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu 
705                 710                 715                 720 


Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln 
                725                 730                 735     


Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu 
            740                 745                 750         


Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile 
        755                 760                 765             


Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp 
    770                 775                 780                 


Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu 
785                 790                 795                 800 


Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly 
                805                 810                 815     


Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu 
            820                 825                 830         


Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val 
        835                 840                 845             


Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly 
    850                 855                 860                 


Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe 
865                 870                 875                 880 


Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro 
                885                 890                 895     


Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys 
            900                 905                 910         


Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu 
        915                 920                 925             


Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys 
    930                 935                 940                 


Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu 
945                 950                 955                 960 


Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg 
                965                 970                 975     


Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr 
            980                 985                 990         


Ser Asp Tyr Ile Lys Gly Ser Asn  Leu Asp Ala Pro Glu  Pro Tyr Arg 
        995                 1000                 1005             


Ile Gly  Arg Ile Lys Glu Ile  Phe Cys Pro Lys Lys  Ser Asn Gly 
    1010                 1015                 1020             


Arg Pro  Asn Glu Thr Asp Ile  Lys Ile Arg Val Asn  Lys Phe Tyr 
    1025                 1030                 1035             


Arg Pro  Glu Asn Thr His Lys  Ser Thr Pro Ala Ser  Tyr His Ala 
    1040                 1045                 1050             


Asp Ile  Asn Leu Leu Tyr Trp  Ser Asp Glu Glu Ala  Val Val Asp 
    1055                 1060                 1065             


Phe Lys  Ala Val Gln Gly Arg  Cys Thr Val Glu Tyr  Gly Glu Asp 
    1070                 1075                 1080             


Leu Pro  Glu Cys Val Gln Val  Tyr Ser Met Gly Gly  Pro Asn Arg 
    1085                 1090                 1095             


Phe Tyr  Phe Leu Glu Ala Tyr  Asn Ala Lys Ser Lys  Ser Phe Glu 
    1100                 1105                 1110             


Asp Pro  Pro Asn His Ala Arg  Ser Pro Gly Asn Lys  Gly Lys Gly 
    1115                 1120                 1125             


Lys Gly  Lys Gly Lys Gly Lys  Pro Lys Ser Gln Ala  Cys Glu Pro 
    1130                 1135                 1140             


Ser Glu  Pro Glu Ile Glu Ile  Lys Leu Pro Lys Leu  Arg Thr Leu 
    1145                 1150                 1155             


Asp Val  Phe Ser Gly Cys Gly  Gly Leu Ser Glu Gly  Phe His Gln 
    1160                 1165                 1170             


Ala Gly  Ile Ser Asp Thr Leu  Trp Ala Ile Glu Met  Trp Asp Pro 
    1175                 1180                 1185             


Ala Ala  Gln Ala Phe Arg Leu  Asn Asn Pro Gly Ser  Thr Val Phe 
    1190                 1195                 1200             


Thr Glu  Asp Cys Asn Ile Leu  Leu Lys Leu Val Met  Ala Gly Glu 
    1205                 1210                 1215             


Thr Thr  Asn Ser Arg Gly Gln  Arg Leu Pro Gln Lys  Gly Asp Val 
    1220                 1225                 1230             


Glu Met  Leu Cys Gly Gly Pro  Pro Cys Gln Gly Phe  Ser Gly Met 
    1235                 1240                 1245             


Asn Arg  Phe Asn Ser Arg Thr  Tyr Ser Lys Phe Lys  Asn Ser Leu 
    1250                 1255                 1260             


Val Val  Ser Phe Leu Ser Tyr  Cys Asp Tyr Tyr Arg  Pro Arg Phe 
    1265                 1270                 1275             


Phe Leu  Leu Glu Asn Val Arg  Asn Phe Val Ser Phe  Lys Arg Ser 
    1280                 1285                 1290             


Met Val  Leu Lys Leu Thr Leu  Arg Cys Leu Val Arg  Met Gly Tyr 
    1295                 1300                 1305             


Gln Cys  Thr Phe Gly Val Leu  Gln Ala Gly Gln Tyr  Gly Val Ala 
    1310                 1315                 1320             


Gln Thr  Arg Arg Arg Ala Ile  Ile Leu Ala Ala Ala  Pro Gly Glu 
    1325                 1330                 1335             


Lys Leu  Pro Leu Phe Pro Glu  Pro Leu His Val Phe  Ala Pro Arg 
    1340                 1345                 1350             


Ala Cys  Gln Leu Ser Val Val  Val Asp Asp Lys Lys  Phe Val Ser 
    1355                 1360                 1365             


Asn Ile  Thr Arg Leu Ser Ser  Gly Pro Phe Arg Thr  Ile Thr Val 
    1370                 1375                 1380             


Arg Asp  Thr Met Ser Asp Leu  Pro Glu Val Arg Asn  Gly Ala Ser 
    1385                 1390                 1395             


Ala Leu  Glu Ile Ser Tyr Asn  Gly Glu Pro Gln Ser  Trp Phe Gln 
    1400                 1405                 1410             


Arg Gln  Leu Arg Gly Ala Gln  Tyr Gln Pro Ile Leu  Arg Asp His 
    1415                 1420                 1425             


Ile Cys  Lys Asp Met Ser Ala  Leu Val Ala Ala Arg  Met Arg His 
    1430                 1435                 1440             


Ile Pro  Leu Ala Pro Gly Ser  Asp Trp Arg Asp Leu  Pro Asn Ile 
    1445                 1450                 1455             


Glu Val  Arg Leu Ser Asp Gly  Thr Met Ala Arg Lys  Leu Arg Tyr 
    1460                 1465                 1470             


Thr His  His Asp Arg Lys Asn  Gly Arg Ser Ser Ser  Gly Ala Leu 
    1475                 1480                 1485             


Arg Gly  Val Cys Ser Cys Val  Glu Ala Gly Lys Ala  Cys Asp Pro 
    1490                 1495                 1500             


Ala Ala  Arg Gln Phe Asn Thr  Leu Ile Pro Trp Cys  Leu Pro His 
    1505                 1510                 1515             


Thr Gly  Asn Arg His Asn His  Trp Ala Gly Leu Tyr  Gly Arg Leu 
    1520                 1525                 1530             


Glu Trp  Asp Gly Phe Phe Ser  Thr Thr Val Thr Asn  Pro Glu Pro 
    1535                 1540                 1545             


Met Gly  Lys Gln Gly Arg Val  Leu His Pro Glu Gln  His Arg Val 
    1550                 1555                 1560             


Val Ser  Val Arg Glu Cys Ala  Arg Ser Gln Gly Phe  Pro Asp Thr 
    1565                 1570                 1575             


Tyr Arg  Leu Phe Gly Asn Ile  Leu Asp Lys His Arg  Gln Val Gly 
    1580                 1585                 1590             


Asn Ala  Val Pro Pro Pro Leu  Ala Lys Ala Ile Gly  Leu Glu Ile 
    1595                 1600                 1605             


Lys Leu  Cys Met Leu Ala Lys  Ala Arg Glu Ser Ala  Ser Ala Lys 
    1610                 1615                 1620             


Ile Lys  Glu Glu Glu Ala Ala  Lys Asp 
    1625                 1630         


<210>  27
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Val Gln Gly Ser Gln Arg Arg Leu Leu Gly Ser Leu Asn Ser 
1               5                   10                  15      


Thr Pro Thr Ala Ile Pro Gln Leu Gly Leu Ala Ala Asn Gln Thr Gly 
            20                  25                  30          


Ala Arg Cys Leu Glu Val Ser Ile Ser Asp Gly Leu Phe Leu Ser Leu 
        35                  40                  45              


Gly Leu Val Ser Leu Val Glu Asn Ala Leu Val Val Ala Thr Ile Ala 
    50                  55                  60                  


Lys Asn Arg Asn Leu His Ser Pro Met Tyr Cys Phe Ile Cys Cys Leu 
65                  70                  75                  80  


Ala Leu Ser Asp Leu Leu Val Ser Gly Ser Asn Val Leu Glu Thr Ala 
                85                  90                  95      


Val Ile Leu Leu Leu Glu Ala Gly Ala Leu Val Ala Arg Ala Ala Val 
            100                 105                 110         


Leu Gln Gln Leu Asp Asn Val Ile Asp Val Ile Thr Cys Ser Ser Met 
        115                 120                 125             


Leu Ser Ser Leu Cys Phe Leu Gly Ala Ile Ala Val Asp Arg Tyr Ile 
    130                 135                 140                 


Ser Ile Phe Tyr Ala Leu Arg Tyr His Ser Ile Val Thr Leu Pro Arg 
145                 150                 155                 160 


Ala Arg Arg Ala Val Ala Ala Ile Trp Val Ala Ser Val Val Phe Ser 
                165                 170                 175     


Thr Leu Phe Ile Ala Tyr Tyr Asp His Val Ala Val Leu Leu Cys Leu 
            180                 185                 190         


Val Val Phe Phe Leu Ala Met Leu Val Leu Met Ala Val Leu Tyr Val 
        195                 200                 205             


His Met Leu Ala Arg Ala Cys Gln His Ala Gln Gly Ile Ala Arg Leu 
    210                 215                 220                 


His Lys Arg Gln Arg Pro Val His Gln Gly Phe Gly Leu Lys Gly Ala 
225                 230                 235                 240 


Val Thr Leu Thr Ile Leu Leu Gly Ile Phe Phe Leu Cys Trp Gly Pro 
                245                 250                 255     


Phe Phe Leu His Leu Thr Leu Ile Val Leu Cys Pro Glu His Pro Thr 
            260                 265                 270         


Cys Gly Cys Ile Phe Lys Asn Phe Asn Leu Phe Leu Ala Leu Ile Ile 
        275                 280                 285             


Cys Asn Ala Ile Ile Asp Pro Leu Ile Tyr Ala Phe His Ser Gln Glu 
    290                 295                 300                 


Leu Arg Arg Thr Leu Lys Glu Val Leu Thr Cys Ser Trp 
305                 310                 315         


<210>  28
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Glu Ala Pro Gln Val Val Glu Ile Asp Pro Asp Phe Glu Pro 
1               5                   10                  15      


Leu Pro Arg Pro Arg Ser Cys Thr Trp Pro Leu Pro Arg Pro Glu Phe 
            20                  25                  30          


Ser Gln Ser Asn Ser Ala Thr Ser Ser Pro Ala Pro Ser Gly Ser Ala 
        35                  40                  45              


Ala Ala Asn Pro Asp Ala Ala Ala Gly Leu Pro Ser Ala Ser Ala Ala 
    50                  55                  60                  


Ala Val Ser Ala Asp Phe Met Ser Asn Leu Ser Leu Leu Glu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Pro Gln Ala Pro Gly Ser Val Ala Ala Ala Val Ala Ala 
                85                  90                  95      


Ala Ala Ala Ala Ala Ala Thr Gly Gly Leu Cys Gly Asp Phe Gln Gly 
            100                 105                 110         


Pro Glu Ala Gly Cys Leu His Pro Ala Pro Pro Gln Pro Pro Pro Pro 
        115                 120                 125             


Gly Pro Leu Ser Gln His Pro Pro Val Pro Pro Ala Ala Ala Gly Pro 
    130                 135                 140                 


Leu Ala Gly Gln Pro Arg Lys Ser Ser Ser Ser Arg Arg Asn Ala Trp 
145                 150                 155                 160 


Gly Asn Leu Ser Tyr Ala Asp Leu Ile Thr Lys Ala Ile Glu Ser Ser 
                165                 170                 175     


Ala Glu Lys Arg Leu Thr Leu Ser Gln Ile Tyr Glu Trp Met Val Lys 
            180                 185                 190         


Ser Val Pro Tyr Phe Lys Asp Lys Gly Asp Ser Asn Ser Ser Ala Gly 
        195                 200                 205             


Trp Lys Asn Ser Ile Arg His Asn Leu Ser Leu His Ser Lys Phe Ile 
    210                 215                 220                 


Arg Val Gln Asn Glu Gly Thr Gly Lys Ser Ser Trp Trp Met Leu Asn 
225                 230                 235                 240 


Pro Glu Gly Gly Lys Ser Gly Lys Ser Pro Arg Arg Arg Ala Ala Ser 
                245                 250                 255     


Met Asp Asn Asn Ser Lys Phe Ala Lys Ser Arg Ser Arg Ala Ala Lys 
            260                 265                 270         


Lys Lys Ala Ser Leu Gln Ser Gly Gln Glu Gly Ala Gly Asp Ser Pro 
        275                 280                 285             


Gly Ser Gln Phe Ser Lys Trp Pro Ala Ser Pro Gly Ser His Ser Asn 
    290                 295                 300                 


Asp Asp Phe Asp Asn Trp Ser Thr Phe Arg Pro Arg Thr Ser Ser Asn 
305                 310                 315                 320 


Ala Ser Thr Ile Ser Gly Arg Leu Ser Pro Ile Met Thr Glu Gln Asp 
                325                 330                 335     


Asp Leu Gly Glu Gly Asp Val His Ser Met Val Tyr Pro Pro Ser Ala 
            340                 345                 350         


Ala Lys Met Ala Ser Thr Leu Pro Ser Leu Ser Glu Ile Ser Asn Pro 
        355                 360                 365             


Glu Asn Met Glu Asn Leu Leu Asp Asn Leu Asn Leu Leu Ser Ser Pro 
    370                 375                 380                 


Thr Ser Leu Thr Val Ser Thr Gln Ser Ser Pro Gly Thr Met Met Gln 
385                 390                 395                 400 


Gln Thr Pro Cys Tyr Ser Phe Ala Pro Pro Asn Thr Ser Leu Asn Ser 
                405                 410                 415     


Pro Ser Pro Asn Tyr Gln Lys Tyr Thr Tyr Gly Gln Ser Ser Met Ser 
            420                 425                 430         


Pro Leu Pro Gln Met Pro Ile Gln Thr Leu Gln Asp Asn Lys Ser Ser 
        435                 440                 445             


Tyr Gly Gly Met Ser Gln Tyr Asn Cys Ala Pro Gly Leu Leu Lys Glu 
    450                 455                 460                 


Leu Leu Thr Ser Asp Ser Pro Pro His Asn Asp Ile Met Thr Pro Val 
465                 470                 475                 480 


Asp Pro Gly Val Ala Gln Pro Asn Ser Arg Val Leu Gly Gln Asn Val 
                485                 490                 495     


Met Met Gly Pro Asn Ser Val Met Ser Thr Tyr Gly Ser Gln Ala Ser 
            500                 505                 510         


His Asn Lys Met Met Asn Pro Ser Ser His Thr His Pro Gly His Ala 
        515                 520                 525             


Gln Gln Thr Ser Ala Val Asn Gly Arg Pro Leu Pro His Thr Val Ser 
    530                 535                 540                 


Thr Met Pro His Thr Ser Gly Met Asn Arg Leu Thr Gln Val Lys Thr 
545                 550                 555                 560 


Pro Val Gln Val Pro Leu Pro His Pro Met Gln Met Ser Ala Leu Gly 
                565                 570                 575     


Gly Tyr Ser Ser Val Ser Ser Cys Asn Gly Tyr Gly Arg Met Gly Leu 
            580                 585                 590         


Leu His Gln Glu Lys Leu Pro Ser Asp Leu Asp Gly Met Phe Ile Glu 
        595                 600                 605             


Arg Leu Asp Cys Asp Met Glu Ser Ile Ile Arg Asn Asp Leu Met Asp 
    610                 615                 620                 


Gly Asp Thr Leu Asp Phe Asn Phe Asp Asn Val Leu Pro Asn Gln Ser 
625                 630                 635                 640 


Phe Pro His Ser Val Lys Thr Thr Thr His Ser Trp Val Ser Gly 
                645                 650                 655 


<210>  29
<211>  2551
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Met Leu Gln His Leu Val Ile Phe Cys Leu Gly Leu Val Val Gln 
1               5                   10                  15      


Asn Phe Cys Ser Pro Ala Glu Thr Thr Gly Gln Ala Arg Arg Cys Asp 
            20                  25                  30          


Arg Lys Ser Leu Leu Thr Ile Arg Thr Glu Cys Arg Ser Cys Ala Leu 
        35                  40                  45              


Asn Leu Gly Val Lys Cys Pro Asp Gly Tyr Thr Met Ile Thr Ser Gly 
    50                  55                  60                  


Ser Val Gly Val Arg Asp Cys Arg Tyr Thr Phe Glu Val Arg Thr Tyr 
65                  70                  75                  80  


Ser Leu Ser Leu Pro Gly Cys Arg His Ile Cys Arg Lys Asp Tyr Leu 
                85                  90                  95      


Gln Pro Arg Cys Cys Pro Gly Arg Trp Gly Pro Asp Cys Ile Glu Cys 
            100                 105                 110         


Pro Gly Gly Ala Gly Ser Pro Cys Asn Gly Arg Gly Ser Cys Ala Glu 
        115                 120                 125             


Gly Met Glu Gly Asn Gly Thr Cys Ser Cys Gln Glu Gly Phe Gly Gly 
    130                 135                 140                 


Thr Ala Cys Glu Thr Cys Ala Asp Asp Asn Leu Phe Gly Pro Ser Cys 
145                 150                 155                 160 


Ser Ser Val Cys Asn Cys Val His Gly Val Cys Asn Ser Gly Leu Asp 
                165                 170                 175     


Gly Asp Gly Thr Cys Glu Cys Tyr Ser Ala Tyr Thr Gly Pro Lys Cys 
            180                 185                 190         


Asp Lys Pro Ile Pro Glu Cys Ala Ala Leu Leu Cys Pro Glu Asn Ser 
        195                 200                 205             


Arg Cys Ser Pro Ser Thr Glu Asp Glu Asn Lys Leu Glu Cys Lys Cys 
    210                 215                 220                 


Leu Pro Asn Tyr Arg Gly Asp Gly Lys Tyr Cys Asp Pro Ile Asn Pro 
225                 230                 235                 240 


Cys Leu Arg Lys Ile Cys His Pro His Ala His Cys Thr Tyr Leu Gly 
                245                 250                 255     


Pro Asn Arg His Ser Cys Thr Cys Gln Glu Gly Tyr Arg Gly Asp Gly 
            260                 265                 270         


Gln Val Cys Leu Pro Val Asp Pro Cys Gln Ile Asn Phe Gly Asn Cys 
        275                 280                 285             


Pro Thr Lys Ser Thr Val Cys Lys Tyr Asp Gly Pro Gly Gln Ser His 
    290                 295                 300                 


Cys Glu Cys Lys Glu His Tyr Gln Asn Phe Val Pro Gly Val Gly Cys 
305                 310                 315                 320 


Ser Met Thr Asp Ile Cys Lys Ser Asp Asn Pro Cys His Arg Asn Ala 
                325                 330                 335     


Asn Cys Thr Thr Val Ala Pro Gly Arg Thr Glu Cys Ile Cys Gln Lys 
            340                 345                 350         


Gly Tyr Val Gly Asp Gly Leu Thr Cys Tyr Gly Asn Ile Met Glu Arg 
        355                 360                 365             


Leu Arg Glu Leu Asn Thr Glu Pro Arg Gly Lys Trp Gln Gly Arg Leu 
    370                 375                 380                 


Thr Ser Phe Ile Ser Leu Leu Asp Lys Ala Tyr Ala Trp Pro Leu Ser 
385                 390                 395                 400 


Lys Leu Gly Pro Phe Thr Val Leu Leu Pro Thr Asp Lys Gly Leu Lys 
                405                 410                 415     


Gly Phe Asn Val Asn Glu Leu Leu Val Asp Asn Lys Ala Ala Gln Tyr 
            420                 425                 430         


Phe Val Lys Leu His Ile Ile Ala Gly Gln Met Asn Ile Glu Tyr Met 
        435                 440                 445             


Asn Asn Thr Asp Met Phe Tyr Thr Leu Thr Gly Lys Ser Gly Glu Ile 
    450                 455                 460                 


Phe Asn Ser Asp Lys Asp Asn Gln Ile Lys Leu Lys Leu His Gly Gly 
465                 470                 475                 480 


Lys Lys Lys Val Lys Ile Ile Gln Gly Asp Ile Ile Ala Ser Asn Gly 
                485                 490                 495     


Leu Leu His Ile Leu Asp Arg Ala Met Asp Lys Leu Glu Pro Thr Phe 
            500                 505                 510         


Glu Ser Asn Asn Glu Gln Thr Ile Met Thr Met Leu Gln Pro Arg Tyr 
        515                 520                 525             


Ser Lys Phe Arg Ser Leu Leu Glu Glu Thr Asn Leu Gly His Ala Leu 
    530                 535                 540                 


Asp Glu Asp Gly Val Gly Gly Pro Tyr Thr Ile Phe Val Pro Asn Asn 
545                 550                 555                 560 


Glu Ala Leu Asn Asn Met Lys Asp Gly Thr Leu Asp Tyr Leu Leu Ser 
                565                 570                 575     


Pro Glu Gly Ser Arg Lys Leu Leu Glu Leu Val Arg Tyr His Ile Val 
            580                 585                 590         


Pro Phe Thr Gln Leu Glu Val Ala Thr Leu Ile Ser Thr Pro His Ile 
        595                 600                 605             


Arg Ser Met Ala Asn Gln Leu Ile Gln Phe Asn Thr Thr Asp Asn Gly 
    610                 615                 620                 


Gln Ile Leu Ala Asn Asp Val Ala Met Glu Glu Ile Glu Ile Thr Ala 
625                 630                 635                 640 


Lys Asn Gly Arg Ile Tyr Thr Leu Thr Gly Val Leu Ile Pro Pro Ser 
                645                 650                 655     


Ile Val Pro Ile Leu Pro His Arg Cys Asp Glu Thr Lys Arg Glu Met 
            660                 665                 670         


Lys Leu Gly Thr Cys Val Ser Cys Ser Leu Val Tyr Trp Ser Arg Cys 
        675                 680                 685             


Pro Ala Asn Ser Glu Pro Thr Ala Leu Phe Thr His Arg Cys Val Tyr 
    690                 695                 700                 


Ser Gly Arg Phe Gly Ser Leu Lys Ser Gly Cys Ala Arg Tyr Cys Asn 
705                 710                 715                 720 


Ala Thr Val Lys Ile Pro Lys Cys Cys Lys Gly Phe Tyr Gly Pro Asp 
                725                 730                 735     


Cys Asn Gln Cys Pro Gly Gly Phe Ser Asn Pro Cys Ser Gly Asn Gly 
            740                 745                 750         


Gln Cys Ala Asp Ser Leu Gly Gly Asn Gly Thr Cys Ile Cys Glu Glu 
        755                 760                 765             


Gly Phe Gln Gly Ser Gln Cys Gln Phe Cys Ser Asp Pro Asn Lys Tyr 
    770                 775                 780                 


Gly Pro Arg Cys Asn Lys Lys Cys Leu Cys Val His Gly Thr Cys Asn 
785                 790                 795                 800 


Asn Arg Ile Asp Ser Asp Gly Ala Cys Leu Thr Gly Thr Cys Arg Asp 
                805                 810                 815     


Gly Ser Ala Gly Arg Leu Cys Asp Lys Gln Thr Ser Ala Cys Gly Pro 
            820                 825                 830         


Tyr Val Gln Phe Cys His Ile His Ala Thr Cys Glu Tyr Ser Asn Gly 
        835                 840                 845             


Thr Ala Ser Cys Ile Cys Lys Ala Gly Tyr Glu Gly Asp Gly Thr Leu 
    850                 855                 860                 


Cys Ser Glu Met Asp Pro Cys Thr Gly Leu Thr Pro Gly Gly Cys Ser 
865                 870                 875                 880 


Arg Asn Ala Glu Cys Ile Lys Thr Gly Thr Gly Thr His Thr Cys Val 
                885                 890                 895     


Cys Gln Gln Gly Trp Thr Gly Asn Gly Arg Asp Cys Ser Glu Ile Asn 
            900                 905                 910         


Asn Cys Leu Leu Pro Ser Ala Gly Gly Cys His Asp Asn Ala Ser Cys 
        915                 920                 925             


Leu Tyr Val Gly Pro Gly Gln Asn Glu Cys Glu Cys Lys Lys Gly Phe 
    930                 935                 940                 


Arg Gly Asn Gly Ile Asp Cys Glu Pro Ile Thr Ser Cys Leu Glu Gln 
945                 950                 955                 960 


Thr Gly Lys Cys His Pro Leu Ala Ser Cys Gln Ser Thr Ser Ser Gly 
                965                 970                 975     


Val Trp Ser Cys Val Cys Gln Glu Gly Tyr Glu Gly Asp Gly Phe Leu 
            980                 985                 990         


Cys Tyr Gly Asn Ala Ala Val Glu  Leu Ser Phe Leu Ser  Glu Ala Ala 
        995                 1000                 1005             


Ile Phe  Asn Arg Trp Ile Asn  Asn Ala Ser Leu Gln  Pro Thr Leu 
    1010                 1015                 1020             


Ser Ala  Thr Ser Asn Leu Thr  Val Leu Val Pro Ser  Gln Gln Ala 
    1025                 1030                 1035             


Thr Glu  Asp Met Asp Gln Asp  Glu Lys Ser Phe Trp  Leu Ser Gln 
    1040                 1045                 1050             


Ser Asn  Ile Pro Ala Leu Ile  Lys Tyr His Met Leu  Leu Gly Thr 
    1055                 1060                 1065             


Tyr Arg  Val Ala Asp Leu Gln  Thr Leu Ser Ser Ser  Asp Met Leu 
    1070                 1075                 1080             


Ala Thr  Ser Leu Gln Gly Asn  Phe Leu His Leu Ala  Lys Val Asp 
    1085                 1090                 1095             


Gly Asn  Ile Thr Ile Glu Gly  Ala Ser Ile Val Asp  Gly Asp Asn 
    1100                 1105                 1110             


Ala Ala  Thr Asn Gly Val Ile  His Ile Ile Asn Lys  Val Leu Val 
    1115                 1120                 1125             


Pro Gln  Arg Arg Leu Thr Gly  Ser Leu Pro Asn Leu  Leu Met Arg 
    1130                 1135                 1140             


Leu Glu  Gln Met Pro Asp Tyr  Ser Ile Phe Arg Gly  Tyr Ile Ile 
    1145                 1150                 1155             


Gln Tyr  Asn Leu Ala Asn Ala  Ile Glu Ala Ala Asp  Ala Tyr Thr 
    1160                 1165                 1170             


Val Phe  Ala Pro Asn Asn Asn  Ala Ile Glu Asn Tyr  Ile Arg Glu 
    1175                 1180                 1185             


Lys Lys  Val Leu Ser Leu Glu  Glu Asp Val Leu Arg  Tyr His Val 
    1190                 1195                 1200             


Val Leu  Glu Glu Lys Leu Leu  Lys Asn Asp Leu His  Asn Gly Met 
    1205                 1210                 1215             


His Arg  Glu Thr Met Leu Gly  Phe Ser Tyr Phe Leu  Ser Phe Phe 
    1220                 1225                 1230             


Leu His  Asn Asp Gln Leu Tyr  Val Asn Glu Ala Pro  Ile Asn Tyr 
    1235                 1240                 1245             


Thr Asn  Val Ala Thr Asp Lys  Gly Val Ile His Gly  Leu Gly Lys 
    1250                 1255                 1260             


Val Leu  Glu Ile Gln Lys Asn  Arg Cys Asp Asn Asn  Asp Thr Thr 
    1265                 1270                 1275             


Ile Ile  Arg Gly Arg Cys Arg  Thr Cys Ser Ser Glu  Leu Thr Cys 
    1280                 1285                 1290             


Pro Phe  Gly Thr Lys Ser Leu  Gly Asn Glu Lys Arg  Arg Cys Ile 
    1295                 1300                 1305             


Tyr Thr  Ser Tyr Phe Met Gly  Arg Arg Thr Leu Phe  Ile Gly Cys 
    1310                 1315                 1320             


Gln Pro  Lys Cys Val Arg Thr  Val Ile Thr Arg Glu  Cys Cys Ala 
    1325                 1330                 1335             


Gly Phe  Phe Gly Pro Gln Cys  Gln Pro Cys Pro Gly  Asn Ala Gln 
    1340                 1345                 1350             


Asn Val  Cys Phe Gly Asn Gly  Ile Cys Leu Asp Gly  Val Asn Gly 
    1355                 1360                 1365             


Thr Gly  Val Cys Glu Cys Gly  Glu Gly Phe Ser Gly  Thr Ala Cys 
    1370                 1375                 1380             


Glu Thr  Cys Thr Glu Gly Lys  Tyr Gly Ile His Cys  Asp Gln Ala 
    1385                 1390                 1395             


Cys Ser  Cys Val His Gly Arg  Cys Asn Gln Gly Pro  Leu Gly Asp 
    1400                 1405                 1410             


Gly Ser  Cys Asp Cys Asp Val  Gly Trp Arg Gly Val  His Cys Asp 
    1415                 1420                 1425             


Asn Ala  Thr Thr Glu Asp Asn  Cys Asn Gly Thr Cys  His Thr Ser 
    1430                 1435                 1440             


Ala Asn  Cys Leu Thr Asn Ser  Asp Gly Thr Ala Ser  Cys Lys Cys 
    1445                 1450                 1455             


Ala Ala  Gly Phe Gln Gly Asn  Gly Thr Ile Cys Thr  Ala Ile Asn 
    1460                 1465                 1470             


Ala Cys  Glu Ile Ser Asn Gly  Gly Cys Ser Ala Lys  Ala Asp Cys 
    1475                 1480                 1485             


Lys Arg  Thr Thr Pro Gly Arg  Arg Val Cys Thr Cys  Lys Ala Gly 
    1490                 1495                 1500             


Tyr Thr  Gly Asp Gly Ile Val  Cys Leu Glu Ile Asn  Pro Cys Leu 
    1505                 1510                 1515             


Glu Asn  His Gly Gly Cys Asp  Lys Asn Ala Glu Cys  Thr Gln Thr 
    1520                 1525                 1530             


Gly Pro  Asn Gln Ala Ala Cys  Asn Cys Leu Pro Ala  Tyr Thr Gly 
    1535                 1540                 1545             


Asp Gly  Lys Val Cys Thr Leu  Ile Asn Val Cys Leu  Thr Lys Asn 
    1550                 1555                 1560             


Gly Gly  Cys Ser Glu Phe Ala  Ile Cys Asn His Thr  Gly Gln Val 
    1565                 1570                 1575             


Glu Arg  Thr Cys Thr Cys Lys  Pro Asn Tyr Ile Gly  Asp Gly Phe 
    1580                 1585                 1590             


Thr Cys  Arg Gly Ser Ile Tyr  Gln Glu Leu Pro Lys  Asn Pro Lys 
    1595                 1600                 1605             


Thr Ser  Gln Tyr Phe Phe Gln  Leu Gln Glu His Phe  Val Lys Asp 
    1610                 1615                 1620             


Leu Val  Gly Pro Gly Pro Phe  Thr Val Phe Ala Pro  Leu Ser Ala 
    1625                 1630                 1635             


Ala Phe  Asp Glu Glu Ala Arg  Val Lys Asp Trp Asp  Lys Tyr Gly 
    1640                 1645                 1650             


Leu Met  Pro Gln Val Leu Arg  Tyr His Val Val Ala  Cys His Gln 
    1655                 1660                 1665             


Leu Leu  Leu Glu Asn Leu Lys  Leu Ile Ser Asn Ala  Thr Ser Leu 
    1670                 1675                 1680             


Gln Gly  Glu Pro Ile Val Ile  Ser Val Ser Gln Ser  Thr Val Tyr 
    1685                 1690                 1695             


Ile Asn  Asn Lys Ala Lys Ile  Ile Ser Ser Asp Ile  Ile Ser Thr 
    1700                 1705                 1710             


Asn Gly  Ile Val His Ile Ile  Asp Lys Leu Leu Ser  Pro Lys Asn 
    1715                 1720                 1725             


Leu Leu  Ile Thr Pro Lys Asp  Asn Ser Gly Arg Ile  Leu Gln Asn 
    1730                 1735                 1740             


Leu Thr  Thr Leu Ala Thr Asn  Asn Gly Tyr Ile Lys  Phe Ser Asn 
    1745                 1750                 1755             


Leu Ile  Gln Asp Ser Gly Leu  Leu Ser Val Ile Thr  Asp Pro Ile 
    1760                 1765                 1770             


His Thr  Pro Val Thr Leu Phe  Trp Pro Thr Asp Gln  Ala Leu His 
    1775                 1780                 1785             


Ala Leu  Pro Ala Glu Gln Gln  Asp Phe Leu Phe Asn  Gln Asp Asn 
    1790                 1795                 1800             


Lys Asp  Lys Leu Lys Glu Tyr  Leu Lys Phe His Val  Ile Arg Asp 
    1805                 1810                 1815             


Ala Lys  Val Leu Ala Val Asp  Leu Pro Thr Ser Thr  Ala Trp Lys 
    1820                 1825                 1830             


Thr Leu  Gln Gly Ser Glu Leu  Ser Val Lys Cys Gly  Ala Gly Arg 
    1835                 1840                 1845             


Asp Ile  Gly Asp Leu Phe Leu  Asn Gly Gln Thr Cys  Arg Ile Val 
    1850                 1855                 1860             


Gln Arg  Glu Leu Leu Phe Asp  Leu Gly Val Ala Tyr  Gly Ile Asp 
    1865                 1870                 1875             


Cys Leu  Leu Ile Asp Pro Thr  Leu Gly Gly Arg Cys  Asp Thr Phe 
    1880                 1885                 1890             


Thr Thr  Phe Asp Ala Ser Gly  Glu Cys Gly Ser Cys  Val Asn Thr 
    1895                 1900                 1905             


Pro Ser  Cys Pro Arg Trp Ser  Lys Pro Lys Gly Val  Lys Gln Lys 
    1910                 1915                 1920             


Cys Leu  Tyr Asn Leu Pro Phe  Lys Arg Asn Leu Glu  Gly Cys Arg 
    1925                 1930                 1935             


Glu Arg  Cys Ser Leu Val Ile  Gln Ile Pro Arg Cys  Cys Lys Gly 
    1940                 1945                 1950             


Tyr Phe  Gly Arg Asp Cys Gln  Ala Cys Pro Gly Gly  Pro Asp Ala 
    1955                 1960                 1965             


Pro Cys  Asn Asn Arg Gly Val  Cys Leu Asp Gln Tyr  Ser Ala Thr 
    1970                 1975                 1980             


Gly Glu  Cys Lys Cys Asn Thr  Gly Phe Asn Gly Thr  Ala Cys Glu 
    1985                 1990                 1995             


Met Cys  Trp Pro Gly Arg Phe  Gly Pro Asp Cys Leu  Pro Cys Gly 
    2000                 2005                 2010             


Cys Ser  Asp His Gly Gln Cys  Asp Asp Gly Ile Thr  Gly Ser Gly 
    2015                 2020                 2025             


Gln Cys  Leu Cys Glu Thr Gly  Trp Thr Gly Pro Ser  Cys Asp Thr 
    2030                 2035                 2040             


Gln Ala  Val Leu Pro Ala Val  Cys Thr Pro Pro Cys  Ser Ala His 
    2045                 2050                 2055             


Ala Thr  Cys Lys Glu Asn Asn  Thr Cys Glu Cys Asn  Leu Asp Tyr 
    2060                 2065                 2070             


Glu Gly  Asp Gly Ile Thr Cys  Thr Val Val Asp Phe  Cys Lys Gln 
    2075                 2080                 2085             


Asp Asn  Gly Gly Cys Ala Lys  Val Ala Arg Cys Ser  Gln Lys Gly 
    2090                 2095                 2100             


Thr Lys  Val Ser Cys Ser Cys  Gln Lys Gly Tyr Lys  Gly Asp Gly 
    2105                 2110                 2115             


His Ser  Cys Thr Glu Ile Asp  Pro Cys Ala Asp Gly  Leu Asn Gly 
    2120                 2125                 2130             


Gly Cys  His Glu His Ala Thr  Cys Lys Met Thr Gly  Pro Gly Lys 
    2135                 2140                 2145             


His Lys  Cys Glu Cys Lys Ser  His Tyr Val Gly Asp  Gly Leu Asn 
    2150                 2155                 2160             


Cys Glu  Pro Glu Gln Leu Pro  Ile Asp Arg Cys Leu  Gln Asp Asn 
    2165                 2170                 2175             


Gly Gln  Cys His Ala Asp Ala  Lys Cys Val Asp Leu  His Phe Gln 
    2180                 2185                 2190             


Asp Thr  Thr Val Gly Val Phe  His Leu Arg Ser Pro  Leu Gly Gln 
    2195                 2200                 2205             


Tyr Lys  Leu Thr Phe Asp Lys  Ala Arg Glu Ala Cys  Ala Asn Glu 
    2210                 2215                 2220             


Ala Ala  Thr Met Ala Thr Tyr  Asn Gln Leu Ser Tyr  Ala Gln Lys 
    2225                 2230                 2235             


Ala Lys  Tyr His Leu Cys Ser  Ala Gly Trp Leu Glu  Thr Gly Arg 
    2240                 2245                 2250             


Val Ala  Tyr Pro Thr Ala Phe  Ala Ser Gln Asn Cys  Gly Ser Gly 
    2255                 2260                 2265             


Val Val  Gly Ile Val Asp Tyr  Gly Pro Arg Pro Asn  Lys Ser Glu 
    2270                 2275                 2280             


Met Trp  Asp Val Phe Cys Tyr  Arg Met Lys Asp Val  Asn Cys Thr 
    2285                 2290                 2295             


Cys Lys  Val Gly Tyr Val Gly  Asp Gly Phe Ser Cys  Ser Gly Asn 
    2300                 2305                 2310             


Leu Leu  Gln Val Leu Met Ser  Phe Pro Ser Leu Thr  Asn Phe Leu 
    2315                 2320                 2325             


Thr Glu  Val Leu Ala Tyr Ser  Asn Ser Ser Ala Arg  Gly Arg Ala 
    2330                 2335                 2340             


Phe Leu  Glu His Leu Thr Asp  Leu Ser Ile Arg Gly  Thr Leu Phe 
    2345                 2350                 2355             


Val Pro  Gln Asn Ser Gly Leu  Gly Glu Asn Glu Thr  Leu Ser Gly 
    2360                 2365                 2370             


Arg Asp  Ile Glu His His Leu  Ala Asn Val Ser Met  Phe Phe Tyr 
    2375                 2380                 2385             


Asn Asp  Leu Val Asn Gly Thr  Thr Leu Gln Thr Arg  Leu Gly Ser 
    2390                 2395                 2400             


Lys Leu  Leu Ile Thr Ala Ser  Gln Asp Pro Leu Gln  Pro Thr Glu 
    2405                 2410                 2415             


Thr Arg  Phe Val Asp Gly Arg  Ala Ile Leu Gln Trp  Asp Ile Phe 
    2420                 2425                 2430             


Ala Ser  Asn Gly Ile Ile His  Val Ile Ser Arg Pro  Leu Lys Ala 
    2435                 2440                 2445             


Pro Pro  Ala Pro Val Thr Leu  Thr His Thr Gly Leu  Gly Ala Gly 
    2450                 2455                 2460             


Ile Phe  Phe Ala Ile Ile Leu  Val Thr Gly Ala Val  Ala Leu Ala 
    2465                 2470                 2475             


Ala Tyr  Ser Tyr Phe Arg Ile  Asn Arg Arg Thr Ile  Gly Phe Gln 
    2480                 2485                 2490             


His Phe  Glu Ser Glu Glu Asp  Ile Asn Val Ala Ala  Leu Gly Lys 
    2495                 2500                 2505             


Gln Gln  Pro Glu Asn Ile Ser  Asn Pro Leu Tyr Glu  Ser Thr Thr 
    2510                 2515                 2520             


Ser Ala  Pro Pro Glu Pro Ser  Tyr Asp Pro Phe Thr  Asp Ser Glu 
    2525                 2530                 2535             


Glu Arg  Gln Leu Glu Gly Asn  Asp Pro Leu Arg Thr  Leu 
    2540                 2545                 2550     


<210>  30
<211>  1061
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Ala Ala Ile Glu Arg Arg Trp Arg Arg Glu Gln Glu Leu Cys 
1               5                   10                  15      


Leu Gln Leu Lys Ser Ser Gln Ala Leu Val Ala Ser Leu Gln Glu Gln 
            20                  25                  30          


Leu Ser Glu Ser Arg Arg Glu Leu Trp Ala Ala Gln Lys Leu Gln Gln 
        35                  40                  45              


Glu Arg Ala Arg Glu Gln Ala Arg Glu Arg Glu Ala Leu Arg Gly Gln 
    50                  55                  60                  


Leu Glu Ala Gln Arg Leu Glu Val Gln Gln Cys Arg Ala Ser Cys Lys 
65                  70                  75                  80  


Leu Leu Gly Arg Glu Lys Ala Ala Leu Glu Met Val Val Glu Glu Leu 
                85                  90                  95      


Lys Gly Lys Ala Asp Ala Ala Asp Ala Glu Lys Gln Gly Leu Glu Ala 
            100                 105                 110         


Glu Ala Ala Glu Leu Gln Arg Ser Leu Leu Leu Gln Ala Glu Arg Arg 
        115                 120                 125             


Glu Glu Leu Ala Leu Arg Arg Glu Arg Ser Cys Arg Ala Leu Glu Thr 
    130                 135                 140                 


Ser Gln Gly Arg Leu Gln Gln Leu Glu Glu Lys Val Ser Gly Leu Arg 
145                 150                 155                 160 


Glu Glu Leu Ala Ser Val Arg Glu Ala Leu Ser Thr Ala Gln Leu Gln 
                165                 170                 175     


Arg Asp Val Val Glu Ser Glu Arg Glu Gly Leu Arg Ser Ala Leu Ala 
            180                 185                 190         


Arg Ala Glu Cys Ser Asn Ala Asp Leu Glu Leu Leu Val Arg Arg Leu 
        195                 200                 205             


Lys Ser Glu Gly Val Glu Gln Arg Asp Ser Leu Ala Ala Met Ala Ala 
    210                 215                 220                 


Leu Met Glu Gly Leu Ala Gln Asp Lys Ser Ala Leu Asn His Leu Ala 
225                 230                 235                 240 


Leu Gln Leu Glu Gln Glu Arg Asp Gln Leu Arg Glu Gln Arg Lys Thr 
                245                 250                 255     


Leu Glu Gln Glu Arg Ala Arg Ala Gly Glu Gln Leu Ala Gln Ala Glu 
            260                 265                 270         


Gln Gln Leu Ala Leu Glu Arg Ala Glu Arg Arg Gly Leu Gln Gln Ala 
        275                 280                 285             


Cys Gly Arg Leu Glu Gln Arg Gln Glu Gln Leu Glu Gly Gln Ala Ala 
    290                 295                 300                 


Leu Leu Gly Arg Glu Lys Ala Gln Leu Gln Glu Gln Val Gly Gln Val 
305                 310                 315                 320 


Thr Cys Gln Lys Gln Ala Leu Glu Glu Gln Leu Ala Gln Ser Leu Gln 
                325                 330                 335     


Asp Gln Glu Ala Gln Met Gly Thr Leu Gln Gln Ala Leu Gln Gly Lys 
            340                 345                 350         


Asp Ala Leu Ser Glu Glu Arg Ala Gln Leu Leu Ala Lys Gln Glu Ala 
        355                 360                 365             


Leu Glu Arg Gln Gly Arg Leu Ala Ala Glu Glu Ala Ala Asp Leu Arg 
    370                 375                 380                 


Val Glu Arg Asp Ser Leu Glu Ser Ser Leu Leu Glu Ala Gln Gln Leu 
385                 390                 395                 400 


Ala Thr Lys Leu Gln Glu Gln Leu Glu Glu Glu Ala Arg Ser Ala Gly 
                405                 410                 415     


Leu Ala Arg Gln Ala Leu Gln Gly Ala Pro Arg Ala Leu Pro Gln Leu 
            420                 425                 430         


Leu Pro Arg Lys Ser Ala Met Glu Gly Pro Leu Glu Trp Ser Ser Val 
        435                 440                 445             


Pro Thr Leu Glu Met Glu Gln Leu Gln Ser Asp Trp Glu Val Gln Glu 
    450                 455                 460                 


Met Lys Leu Arg Gln Asp Thr Val Arg Leu Gln Arg Gln Val Ala Gln 
465                 470                 475                 480 


Gln Glu Arg Glu Ala Gln Arg Ala Leu Glu Ser Gln Ala Leu Ala His 
                485                 490                 495     


Arg Glu Ala Leu Ala Gln Leu Gln Arg Glu Lys Glu Thr Leu Ser Leu 
            500                 505                 510         


Thr Leu Ala Glu Glu Lys Glu Val Ala Arg Cys Gln Leu Glu Gln Glu 
        515                 520                 525             


Lys Glu Leu Val Thr Lys Ser Ala Ala Glu Arg Glu Ala Leu Lys Gly 
    530                 535                 540                 


Glu Ile Gln Ser Leu Lys Gln Glu Arg Asp Glu Ser Leu Leu Gln Leu 
545                 550                 555                 560 


Glu His Lys Met Gln Gln Val Met Ala Leu Ser Leu Lys Glu Thr Glu 
                565                 570                 575     


Arg Ser Leu Leu Ser Glu Glu Leu Ser Arg Ala Arg Arg Thr Leu Glu 
            580                 585                 590         


Arg Val Gln Gln Glu Ala Gln Ser Gln Gln Glu Gln Ala Gln Arg Gly 
        595                 600                 605             


Leu Leu Trp Ser Gln Cys Trp Leu Leu Glu Pro Ser Leu Glu Leu Ala 
    610                 615                 620                 


Leu Ser Leu Pro Arg Thr Arg Tyr Gln Ala Cys Gln Pro Ala Gly Leu 
625                 630                 635                 640 


Pro Gly Glu Leu Val Lys Gly Ser Phe Ala Thr Ser Ala Gln Lys Met 
                645                 650                 655     


Glu Ile Lys Thr Val Glu Arg Ser Gly Arg Arg Gly Met Pro Ala Lys 
            660                 665                 670         


Glu His Gln Ala Pro Asp Asp Arg Thr Ala Asn Thr Lys Pro Ala Leu 
        675                 680                 685             


Glu Gly Ala Ile Pro His Gln Pro Pro Pro Ala Ser Arg Leu Leu Leu 
    690                 695                 700                 


Pro Gly Gly Leu Ala Thr Ile Ser Ala Thr Thr Glu Glu Leu Lys Ala 
705                 710                 715                 720 


Leu Gln Ala Gln Phe Glu Asp Ala Ile Thr Ala His Gln Arg Glu Thr 
                725                 730                 735     


Thr Ala Leu Arg Glu Ser Leu Gln Asp Leu Ala Ala Glu Arg Gly Asp 
            740                 745                 750         


Val Glu Arg Glu Ala Glu Arg Leu Arg Ala Gln Leu Thr Val Ala Gln 
        755                 760                 765             


Glu Gly Leu Ala Ala Leu Arg Gln Glu Leu Gln Gly Val Glu Glu Ser 
    770                 775                 780                 


Arg Glu Gly Leu His Arg Glu Ala Gln Glu Ala Arg Arg Ala Leu Ser 
785                 790                 795                 800 


Asp Glu Ala Arg Glu Lys Asp Val Leu Leu Leu Phe Asn Ser Glu Leu 
                805                 810                 815     


Arg Ala Thr Ile Cys Arg Ala Glu Gln Glu Lys Ala Ser Phe Lys Arg 
            820                 825                 830         


Ser Lys Glu Glu Lys Glu Gln Lys Leu Leu Ile Leu Glu Glu Ala Gln 
        835                 840                 845             


Ala Ala Leu Gln Gln Glu Ala Ser Ala Leu Arg Ala His Leu Trp Glu 
    850                 855                 860                 


Leu Glu Gln Ala Gly Gly Asp Ala Arg Gln Glu Leu Arg Glu Leu His 
865                 870                 875                 880 


Arg Gln Val Arg Thr Leu Lys Ala Glu Asn Gln Arg Arg Ser Gly Glu 
                885                 890                 895     


Ala His Glu Leu Gln Ala Gln Cys Ser Gln Glu Val Leu Glu Leu Arg 
            900                 905                 910         


Arg Gln Ala Ala Lys Ala Glu Ala Lys His Glu Gly Ala Arg Lys Glu 
        915                 920                 925             


Val Leu Gly Leu Gln Arg Lys Leu Ala Glu Val Glu Ala Ala Gly Glu 
    930                 935                 940                 


Ala His Gly Gln Arg Leu Gln Glu His Leu Arg Glu Ser Arg Gly Ala 
945                 950                 955                 960 


Glu Gln Thr Leu Arg Ala Glu Leu His Ser Val Thr Arg Lys Leu Gln 
                965                 970                 975     


Glu Ala Ser Gly Val Ala Asp Ala Leu Gln Ala Arg Leu Asp Gln Ala 
            980                 985                 990         


Cys His Arg Ile His Ser Leu Glu  Gln Glu Leu Ala Gln  Ala Glu Gly 
        995                 1000                 1005             


Ala Arg  Gln Asp Ala Glu Ala  Gln Leu Gly Arg Leu  Cys Ser Thr 
    1010                 1015                 1020             


Leu Arg  Arg Gly Leu Gly Leu  Gln Arg Gln Ser Pro  Trp Ala Ser 
    1025                 1030                 1035             


Pro Glu  Gln Pro Gly Ser Pro  Thr Lys Gly Leu Thr  Thr His Thr 
    1040                 1045                 1050             


Val Arg  Asp Ser Asp Arg Gln  Leu 
    1055                 1060     


<210>  31
<211>  1983
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Gly Asn Lys Arg Gly Ser Arg Ala Ser Cys Pro His Arg Gly 
1               5                   10                  15      


Ala Glu Cys Leu Leu Pro Trp Ala Ala Leu Asn Leu Gln Gly Phe Gln 
            20                  25                  30          


Leu Leu Leu Leu His Pro Ser Ala Thr Ala Met Met Asp Val Ser Glu 
        35                  40                  45              


Leu Gly Glu Ser Ala Arg Tyr Leu Arg Gln Gly Tyr Gln Glu Met Thr 
    50                  55                  60                  


Lys Val His Thr Ile Pro Trp Asp Gly Lys Lys Arg Val Trp Val Pro 
65                  70                  75                  80  


Asp Glu Gln Asp Ala Tyr Val Glu Ala Glu Val Lys Ser Glu Ala Thr 
                85                  90                  95      


Gly Gly Arg Val Thr Val Glu Thr Lys Asp Gln Lys Val Leu Met Val 
            100                 105                 110         


Arg Glu Ala Glu Leu Gln Pro Met Asn Pro Pro Arg Phe Asp Leu Leu 
        115                 120                 125             


Glu Asp Met Ala Met Met Thr His Leu Asn Glu Ala Ser Val Leu His 
    130                 135                 140                 


Asn Leu Arg Gln Arg Tyr Ala Arg Trp Met Ile Tyr Thr Tyr Ser Gly 
145                 150                 155                 160 


Leu Phe Cys Val Thr Ile Asn Pro Tyr Lys Trp Leu Pro Val Tyr Thr 
                165                 170                 175     


Ala Ser Val Val Ala Ala Tyr Lys Gly Lys Arg Arg Ser Asp Ser Pro 
            180                 185                 190         


Pro His Ile Tyr Ala Val Ala Asp Asn Ala Tyr Asn Asp Met Leu Arg 
        195                 200                 205             


Asn Arg Asp Asn Gln Ser Met Leu Ile Thr Gly Glu Ser Gly Ala Gly 
    210                 215                 220                 


Lys Thr Val Asn Thr Lys Arg Val Ile Gln Tyr Phe Ala Ile Val Ala 
225                 230                 235                 240 


Ala Leu Gly Asp Gly Pro Gly Lys Lys Ala Gln Phe Leu Ala Thr Lys 
                245                 250                 255     


Thr Gly Gly Thr Leu Glu Asp Gln Ile Ile Glu Ala Asn Pro Ala Met 
            260                 265                 270         


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
        275                 280                 285             


Phe Gly Lys Phe Ile Arg Ile His Phe Gly Pro Ser Gly Lys Leu Ala 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ser Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
305                 310                 315                 320 


Gln Leu Pro Gly Glu Arg Ser Tyr His Val Tyr Tyr Gln Ile Leu Ser 
                325                 330                 335     


Gly Arg Lys Pro Glu Leu Gln Asp Met Leu Leu Leu Ser Met Asn Pro 
            340                 345                 350         


Tyr Asp Tyr His Phe Cys Ser Gln Gly Val Ile Thr Val Asp Asn Met 
        355                 360                 365             


Asn Asp Gly Glu Glu Leu Ile Ala Thr Asp His Ala Met Asp Ile Leu 
    370                 375                 380                 


Gly Phe Ser Val Asp Glu Lys Cys Ala Cys Tyr Lys Ile Val Gly Ala 
385                 390                 395                 400 


Leu Leu His Phe Gly Asn Met Lys Phe Lys Gln Lys Gln Arg Glu Glu 
                405                 410                 415     


Gln Ala Glu Ala Asp Gly Thr Glu Ser Ala Asp Lys Ala Ala Tyr Leu 
            420                 425                 430         


Met Gly Val Ser Ser Gly Asp Leu Leu Lys Gly Leu Leu His Pro Arg 
        435                 440                 445             


Val Arg Val Gly Asn Glu Tyr Val Thr Lys Gly Gln Ser Val Glu Gln 
    450                 455                 460                 


Val Val Phe Ala Val Gly Ala Leu Ala Lys Ala Thr Tyr Asp Arg Leu 
465                 470                 475                 480 


Phe Arg Trp Leu Val Ser Arg Ile Asn Gln Thr Leu Asp Thr Lys Leu 
                485                 490                 495     


Pro Arg Gln Phe Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Ile 
            500                 505                 510         


Phe Glu Phe Asn Ser Phe Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu 
        515                 520                 525             


Lys Leu Gln Gln Phe Phe Asn Gln His Met Phe Val Leu Glu Gln Glu 
    530                 535                 540                 


Glu Tyr Lys Arg Glu Gly Ile Asp Trp Val Phe Ile Asp Phe Gly Leu 
545                 550                 555                 560 


Asp Leu Gln Pro Cys Ile Asp Leu Ile Glu Lys Pro Leu Gly Ile Leu 
                565                 570                 575     


Ser Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Ser Asp Ala Ser 
            580                 585                 590         


Phe Arg Ala Lys Leu Tyr Asp Asn His Ala Gly Lys Ser Pro Asn Phe 
        595                 600                 605             


Gln Gln Pro Arg Pro Asp Lys Lys Arg Lys Tyr Gln Ala His Phe Glu 
    610                 615                 620                 


Val Val His Tyr Ala Gly Val Val Pro Tyr Ser Ile Val Gly Trp Leu 
625                 630                 635                 640 


Glu Lys Asn Lys Asp Pro Leu Asn Glu Thr Val Val Pro Ile Phe Gln 
                645                 650                 655     


Lys Ser Gln Asn Arg Leu Leu Ala Thr Leu Tyr Glu Asn Tyr Ala Gly 
            660                 665                 670         


Ser Cys Ser Thr Glu Pro Pro Lys Ser Gly Val Lys Glu Lys Arg Lys 
        675                 680                 685             


Lys Ala Ala Ser Phe Gln Thr Val Ser Gln Leu His Lys Glu Asn Leu 
    690                 695                 700                 


Asn Lys Leu Met Thr Asn Leu Arg Ala Thr Gln Pro His Phe Val Arg 
705                 710                 715                 720 


Cys Ile Val Pro Asn Glu Asn Lys Thr Pro Gly Val Met Asp Ala Phe 
                725                 730                 735     


Leu Val Leu His Gln Leu Arg Cys Asn Gly Val Leu Glu Gly Ile Arg 
            740                 745                 750         


Ile Cys Arg Gln Gly Phe Pro Asn Arg Leu Leu Tyr Thr Asp Phe Arg 
        755                 760                 765             


Gln Arg Tyr Arg Ile Leu Asn Pro Ser Ala Ile Pro Asp Asp Thr Phe 
    770                 775                 780                 


Met Asp Ser Arg Lys Ala Thr Glu Lys Leu Leu Gly Ser Leu Asp Leu 
785                 790                 795                 800 


Asp His Thr Gln Tyr Gln Phe Gly His Thr Lys Val Phe Phe Lys Ala 
                805                 810                 815     


Gly Leu Leu Gly Val Leu Glu Glu Leu Arg Asp Gln Arg Leu Ala Lys 
            820                 825                 830         


Val Leu Thr Leu Leu Gln Ala Arg Ser Arg Gly Arg Leu Met Arg Leu 
        835                 840                 845             


Glu Tyr Gln Arg Leu Leu Gly Gly Arg Asp Ala Leu Phe Thr Ile Gln 
    850                 855                 860                 


Trp Asn Ile Arg Ala Phe Asn Ala Val Lys Asn Trp Ser Trp Met Lys 
865                 870                 875                 880 


Leu Phe Phe Lys Met Lys Pro Leu Leu Arg Ser Ala Gln Ala Glu Glu 
                885                 890                 895     


Glu Leu Ala Ala Leu Arg Ala Glu Leu Arg Gly Leu Arg Gly Ala Leu 
            900                 905                 910         


Ala Ala Ala Glu Ala Lys Arg Gln Glu Leu Glu Glu Thr His Val Ser 
        915                 920                 925             


Ile Thr Gln Glu Lys Asn Asp Leu Ala Leu Gln Leu Gln Ala Glu Gln 
    930                 935                 940                 


Asp Asn Leu Ala Asp Ala Glu Glu Arg Cys His Leu Leu Ile Lys Ser 
945                 950                 955                 960 


Lys Val Gln Leu Glu Gly Lys Val Lys Glu Leu Ser Glu Arg Leu Glu 
                965                 970                 975     


Asp Glu Glu Glu Val Asn Ala Asp Leu Ala Ala Arg Arg Arg Lys Leu 
            980                 985                 990         


Glu Asp Glu Cys Thr Glu Leu Lys  Lys Asp Ile Asp Asp  Leu Glu Leu 
        995                 1000                 1005             


Thr Leu  Ala Lys Ala Glu Lys  Glu Lys Gln Ala Thr  Glu Asn Lys 
    1010                 1015                 1020             


Val Lys  Asn Leu Thr Glu Glu  Met Ala Ala Leu Asp  Glu Ser Val 
    1025                 1030                 1035             


Ala Arg  Leu Thr Lys Glu Lys  Lys Ala Leu Gln Glu  Ala His Gln 
    1040                 1045                 1050             


Gln Ala  Leu Gly Asp Leu Gln  Ala Glu Glu Asp Arg  Val Ser Ala 
    1055                 1060                 1065             


Leu Thr  Lys Ala Lys Leu Arg  Leu Glu Gln Gln Val  Glu Asp Leu 
    1070                 1075                 1080             


Glu Cys  Ser Leu Glu Gln Glu  Lys Lys Leu Arg Met  Asp Thr Glu 
    1085                 1090                 1095             


Arg Ala  Lys Arg Lys Leu Glu  Gly Asp Leu Lys Leu  Thr Gln Glu 
    1100                 1105                 1110             


Ser Val  Ala Asp Ala Ala Gln  Asp Lys Gln Gln Leu  Glu Glu Lys 
    1115                 1120                 1125             


Leu Lys  Lys Lys Asp Ser Glu  Leu Ser Gln Leu Ser  Leu Arg Val 
    1130                 1135                 1140             


Glu Asp  Glu Gln Leu Leu Gly  Ala Gln Met Gln Lys  Lys Ile Lys 
    1145                 1150                 1155             


Glu Leu  Gln Ala Arg Ala Glu  Glu Leu Glu Glu Glu  Leu Glu Ala 
    1160                 1165                 1170             


Glu Arg  Ala Ala Arg Ala Arg  Val Glu Lys Gln Arg  Ala Glu Ala 
    1175                 1180                 1185             


Ala Arg  Glu Leu Glu Glu Leu  Ser Glu Arg Leu Glu  Glu Ala Gly 
    1190                 1195                 1200             


Gly Ala  Ser Ala Gly Gln Arg  Glu Gly Cys Arg Lys  Arg Glu Ala 
    1205                 1210                 1215             


Glu Leu  Gly Arg Leu Arg Arg  Glu Leu Glu Glu Ala  Ala Leu Arg 
    1220                 1225                 1230             


His Glu  Ala Thr Val Ala Ala  Leu Arg Arg Lys Gln  Ala Glu Gly 
    1235                 1240                 1245             


Ala Ala  Glu Leu Gly Glu Gln  Val Asp Ser Leu Gln  Arg Val Arg 
    1250                 1255                 1260             


Gln Lys  Leu Glu Lys Glu Lys  Ser Glu Leu Arg Met  Glu Val Asp 
    1265                 1270                 1275             


Asp Leu  Ala Ala Asn Val Glu  Thr Leu Thr Arg Ala  Lys Ala Ser 
    1280                 1285                 1290             


Ala Glu  Lys Leu Cys Arg Thr  Tyr Glu Asp Gln Leu  Ser Glu Ala 
    1295                 1300                 1305             


Lys Ile  Lys Val Glu Glu Leu  Gln Arg Gln Leu Ala  Asp Ala Ser 
    1310                 1315                 1320             


Thr Gln  Arg Gly Arg Leu Gln  Thr Glu Ser Gly Glu  Leu Ser Arg 
    1325                 1330                 1335             


Leu Leu  Glu Glu Lys Glu Cys  Leu Ile Ser Gln Leu  Ser Arg Gly 
    1340                 1345                 1350             


Lys Ala  Leu Ala Ala Gln Ser  Leu Glu Glu Leu Arg  Arg Gln Leu 
    1355                 1360                 1365             


Glu Glu  Glu Ser Lys Ala Lys  Ser Ala Leu Ala His  Ala Val Gln 
    1370                 1375                 1380             


Ala Leu  Arg His Asp Cys Asp  Leu Leu Arg Glu Gln  His Glu Glu 
    1385                 1390                 1395             


Glu Ala  Glu Ala Gln Ala Glu  Leu Gln Arg Leu Leu  Ser Lys Ala 
    1400                 1405                 1410             


Asn Ala  Glu Val Ala Gln Trp  Arg Ser Lys Tyr Glu  Ala Asp Ala 
    1415                 1420                 1425             


Ile Gln  Arg Thr Glu Glu Leu  Glu Glu Ala Lys Lys  Lys Leu Ala 
    1430                 1435                 1440             


Leu Arg  Leu Gln Glu Ala Glu  Glu Gly Val Glu Ala  Ala Asn Ala 
    1445                 1450                 1455             


Lys Cys  Ser Ser Leu Glu Lys  Ala Lys Leu Arg Leu  Gln Thr Glu 
    1460                 1465                 1470             


Ser Glu  Asp Val Thr Leu Glu  Leu Glu Arg Ala Thr  Ser Ala Ala 
    1475                 1480                 1485             


Ala Ala  Leu Asp Lys Lys Gln  Arg His Leu Glu Arg  Ala Leu Glu 
    1490                 1495                 1500             


Glu Arg  Arg Arg Gln Glu Glu  Glu Met Gln Arg Glu  Leu Glu Ala 
    1505                 1510                 1515             


Ala Gln  Arg Glu Ser Arg Gly  Leu Gly Thr Glu Leu  Phe Arg Leu 
    1520                 1525                 1530             


Arg His  Gly His Glu Glu Ala  Leu Glu Ala Leu Glu  Thr Leu Lys 
    1535                 1540                 1545             


Arg Glu  Asn Lys Asn Leu Gln  Glu Glu Ile Ser Asp  Leu Thr Asp 
    1550                 1555                 1560             


Gln Val  Ser Leu Ser Gly Lys  Ser Ile Gln Glu Leu  Glu Lys Thr 
    1565                 1570                 1575             


Lys Lys  Ala Leu Glu Gly Glu  Lys Ser Glu Ile Gln  Ala Ala Leu 
    1580                 1585                 1590             


Glu Glu  Ala Glu Gly Ala Leu  Glu Leu Glu Glu Thr  Lys Thr Leu 
    1595                 1600                 1605             


Arg Ile  Gln Leu Glu Leu Ser  Gln Val Lys Ala Glu  Val Asp Arg 
    1610                 1615                 1620             


Lys Leu  Ala Glu Lys Asp Glu  Glu Cys Ala Asn Leu  Arg Arg Asn 
    1625                 1630                 1635             


His Gln  Arg Ala Val Glu Ser  Leu Gln Ala Ser Leu  Asp Ala Glu 
    1640                 1645                 1650             


Thr Arg  Ala Arg Asn Glu Ala  Leu Arg Leu Lys Lys  Lys Met Glu 
    1655                 1660                 1665             


Gly Asp  Leu Asn Asp Leu Glu  Leu Gln Leu Gly His  Ala Thr Arg 
    1670                 1675                 1680             


Gln Ala  Thr Glu Ala Gln Ala  Ala Thr Arg Leu Met  Gln Ala Gln 
    1685                 1690                 1695             


Leu Lys  Glu Glu Gln Ala Gly  Arg Asp Glu Glu Gln  Arg Leu Ala 
    1700                 1705                 1710             


Ala Glu  Leu His Glu Gln Ala  Gln Ala Leu Glu Arg  Arg Ala Ser 
    1715                 1720                 1725             


Leu Leu  Ala Ala Glu Leu Glu  Glu Leu Arg Ala Ala  Leu Glu Gln 
    1730                 1735                 1740             


Gly Glu  Arg Ser Arg Arg Leu  Ala Glu Gln Glu Leu  Leu Glu Ala 
    1745                 1750                 1755             


Thr Glu  Arg Leu Asn Leu Leu  His Ser Gln Asn Thr  Gly Leu Leu 
    1760                 1765                 1770             


Asn Gln  Lys Lys Lys Leu Glu  Ala Asp Leu Ala Gln  Leu Ser Gly 
    1775                 1780                 1785             


Glu Val  Glu Glu Ala Ala Gln  Glu Arg Arg Glu Ala  Glu Glu Lys 
    1790                 1795                 1800             


Ala Lys  Lys Ala Ile Thr Asp  Ala Ala Met Met Ala  Glu Glu Leu 
    1805                 1810                 1815             


Lys Lys  Glu Gln Asp Thr Ser  Ala His Leu Glu Arg  Met Lys Lys 
    1820                 1825                 1830             


Thr Leu  Glu Gln Thr Val Arg  Glu Leu Gln Ala Arg  Leu Glu Glu 
    1835                 1840                 1845             


Ala Glu  Gln Ala Ala Leu Arg  Gly Gly Lys Lys Gln  Val Gln Lys 
    1850                 1855                 1860             


Leu Glu  Ala Lys Val Arg Glu  Leu Glu Ala Glu Leu  Asp Ala Glu 
    1865                 1870                 1875             


Gln Lys  Lys His Ala Glu Ala  Leu Lys Gly Val Arg  Lys His Glu 
    1880                 1885                 1890             


Arg Arg  Val Lys Glu Leu Ala  Tyr Gln Ala Glu Glu  Asp Arg Lys 
    1895                 1900                 1905             


Asn Leu  Ala Arg Met Gln Asp  Leu Val Asp Lys Leu  Gln Ser Lys 
    1910                 1915                 1920             


Val Lys  Ser Tyr Lys Arg Gln  Phe Glu Glu Ala Glu  Gln Gln Ala 
    1925                 1930                 1935             


Asn Thr  Asn Leu Ala Lys Tyr  Arg Lys Ala Gln His  Glu Leu Asp 
    1940                 1945                 1950             


Asp Ala  Glu Glu Arg Ala Asp  Met Ala Glu Thr Gln  Ala Asn Lys 
    1955                 1960                 1965             


Leu Arg  Ala Arg Thr Arg Asp  Ala Leu Gly Pro Lys  His Lys Glu 
    1970                 1975                 1980             


<210>  32
<211>  1331
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Ser His Ser Arg Ala Gly Lys Ser Arg Lys Ser Ala Lys Phe 
1               5                   10                  15      


Arg Ser Ile Ser Arg Ser Leu Met Leu Cys Asn Ala Lys Thr Ser Asp 
            20                  25                  30          


Asp Gly Ser Ser Pro Asp Glu Lys Tyr Pro Asp Pro Phe Glu Ile Ser 
        35                  40                  45              


Leu Ala Gln Gly Lys Glu Gly Ile Phe His Ser Ser Val Gln Leu Ala 
    50                  55                  60                  


Asp Thr Ser Glu Ala Gly Pro Ser Ser Val Pro Asp Leu Ala Leu Ala 
65                  70                  75                  80  


Ser Glu Ala Ala Gln Leu Gln Ala Ala Gly Asn Asp Arg Gly Lys Thr 
                85                  90                  95      


Cys Arg Arg Ile Phe Phe Met Lys Glu Ser Ser Thr Ala Ser Ser Arg 
            100                 105                 110         


Glu Lys Pro Gly Lys Leu Glu Ala Gln Ser Ser Asn Phe Leu Phe Pro 
        115                 120                 125             


Lys Ala Cys His Gln Arg Ala Arg Ser Asn Ser Thr Ser Val Asn Pro 
    130                 135                 140                 


Tyr Cys Thr Arg Glu Ile Asp Phe Pro Met Thr Lys Lys Ser Ala Ala 
145                 150                 155                 160 


Pro Thr Asp Arg Gln Pro Tyr Ser Leu Cys Ser Asn Arg Lys Ser Leu 
                165                 170                 175     


Ser Gln Gln Leu Asp Cys Pro Ala Gly Lys Ala Ala Gly Thr Ser Arg 
            180                 185                 190         


Pro Thr Arg Ser Leu Ser Thr Ala Gln Leu Val Gln Pro Ser Gly Gly 
        195                 200                 205             


Leu Gln Ala Ser Val Ile Ser Asn Ile Val Leu Met Lys Gly Gln Ala 
    210                 215                 220                 


Lys Gly Leu Gly Phe Ser Ile Val Gly Gly Lys Asp Ser Ile Tyr Gly 
225                 230                 235                 240 


Pro Ile Gly Ile Tyr Val Lys Thr Ile Phe Ala Gly Gly Ala Ala Ala 
                245                 250                 255     


Ala Asp Gly Arg Leu Gln Glu Gly Asp Glu Ile Leu Glu Leu Asn Gly 
            260                 265                 270         


Glu Ser Met Ala Gly Leu Thr His Gln Asp Ala Leu Gln Lys Phe Lys 
        275                 280                 285             


Gln Ala Lys Lys Gly Leu Leu Thr Leu Thr Val Arg Thr Arg Leu Thr 
    290                 295                 300                 


Ala Pro Pro Ser Leu Cys Ser His Leu Ser Pro Pro Leu Cys Arg Ser 
305                 310                 315                 320 


Leu Ser Ser Ser Thr Cys Ile Thr Lys Asp Ser Ser Ser Phe Ala Leu 
                325                 330                 335     


Glu Ser Pro Ser Ala Pro Ile Ser Thr Ala Lys Pro Asn Tyr Arg Ile 
            340                 345                 350         


Met Val Glu Val Ser Leu Gln Lys Glu Ala Gly Val Gly Leu Gly Ile 
        355                 360                 365             


Gly Leu Cys Ser Val Pro Tyr Phe Gln Cys Ile Ser Gly Ile Phe Val 
    370                 375                 380                 


His Thr Leu Ser Pro Gly Ser Val Ala His Leu Asp Gly Arg Leu Arg 
385                 390                 395                 400 


Cys Gly Asp Glu Ile Val Glu Ile Ser Asp Ser Pro Val His Cys Leu 
                405                 410                 415     


Thr Leu Asn Glu Val Tyr Thr Ile Leu Ser His Cys Asp Pro Gly Pro 
            420                 425                 430         


Val Pro Ile Ile Val Ser Arg His Pro Asp Pro Gln Val Ser Glu Gln 
        435                 440                 445             


Gln Leu Lys Glu Ala Val Ala Gln Ala Val Glu Asn Thr Lys Phe Gly 
    450                 455                 460                 


Lys Glu Arg His Gln Trp Ser Leu Glu Gly Val Lys Arg Leu Glu Ser 
465                 470                 475                 480 


Ser Trp His Gly Arg Pro Thr Leu Glu Lys Glu Arg Glu Lys Asn Ser 
                485                 490                 495     


Ala Pro Pro His Arg Arg Ala Gln Lys Val Met Ile Arg Ser Ser Ser 
            500                 505                 510         


Asp Ser Ser Tyr Met Ser Gly Ser Pro Gly Gly Ser Pro Gly Ser Gly 
        515                 520                 525             


Ser Ala Glu Lys Pro Ser Ser Asp Val Asp Ile Ser Thr His Ser Pro 
    530                 535                 540                 


Ser Leu Pro Leu Ala Arg Glu Pro Val Val Leu Ser Ile Ala Ser Ser 
545                 550                 555                 560 


Arg Leu Pro Gln Glu Ser Pro Pro Leu Pro Glu Ser Arg Asp Ser His 
                565                 570                 575     


Pro Pro Leu Arg Leu Lys Lys Ser Phe Glu Ile Leu Val Arg Lys Pro 
            580                 585                 590         


Met Ser Ser Lys Pro Lys Pro Pro Pro Arg Lys Tyr Phe Lys Ser Asp 
        595                 600                 605             


Ser Asp Pro Gln Lys Ser Leu Glu Glu Arg Glu Asn Ser Ser Cys Ser 
    610                 615                 620                 


Ser Gly His Thr Pro Pro Thr Cys Gly Gln Glu Ala Arg Glu Leu Leu 
625                 630                 635                 640 


Pro Leu Leu Leu Pro Gln Glu Asp Thr Ala Gly Arg Ser Pro Ser Ala 
                645                 650                 655     


Ser Ala Gly Cys Pro Gly Pro Gly Ile Gly Pro Gln Thr Lys Ser Ser 
            660                 665                 670         


Thr Glu Gly Glu Pro Gly Trp Arg Arg Ala Ser Pro Val Thr Gln Thr 
        675                 680                 685             


Ser Pro Ile Lys His Pro Leu Leu Lys Arg Gln Ala Arg Met Asp Tyr 
    690                 695                 700                 


Ser Phe Asp Thr Thr Ala Glu Asp Pro Trp Val Arg Ile Ser Asp Cys 
705                 710                 715                 720 


Ile Lys Asn Leu Phe Ser Pro Ile Met Ser Glu Asn His Gly His Met 
                725                 730                 735     


Pro Leu Gln Pro Asn Ala Ser Leu Asn Glu Glu Glu Gly Thr Gln Gly 
            740                 745                 750         


His Pro Asp Gly Thr Pro Pro Lys Leu Asp Thr Ala Asn Gly Thr Pro 
        755                 760                 765             


Lys Val Tyr Lys Ser Ala Asp Ser Ser Thr Val Lys Lys Gly Pro Pro 
    770                 775                 780                 


Val Ala Pro Lys Pro Ala Trp Phe Arg Gln Ser Leu Lys Gly Leu Arg 
785                 790                 795                 800 


Asn Arg Ala Ser Asp Pro Arg Gly Leu Pro Asp Pro Ala Leu Ser Thr 
                805                 810                 815     


Gln Pro Ala Pro Ala Ser Arg Glu His Leu Gly Ser His Ile Arg Ala 
            820                 825                 830         


Ser Ser Ser Ser Ser Ser Ile Arg Gln Arg Ile Ser Ser Phe Glu Thr 
        835                 840                 845             


Phe Gly Ser Ser Gln Leu Pro Asp Lys Gly Ala Gln Arg Leu Ser Leu 
    850                 855                 860                 


Gln Pro Ser Ser Gly Glu Ala Ala Lys Pro Leu Gly Lys His Glu Glu 
865                 870                 875                 880 


Gly Arg Phe Ser Gly Leu Leu Gly Arg Gly Ala Ala Pro Thr Leu Val 
                885                 890                 895     


Pro Gln Gln Pro Glu Gln Val Leu Ser Ser Gly Ser Pro Ala Ala Ser 
            900                 905                 910         


Glu Ala Arg Asp Pro Gly Val Ser Glu Ser Pro Pro Pro Gly Arg Gln 
        915                 920                 925             


Pro Asn Gln Lys Thr Leu Pro Pro Gly Pro Asp Pro Leu Leu Arg Leu 
    930                 935                 940                 


Leu Ser Thr Gln Ala Glu Glu Ser Gln Gly Pro Val Leu Lys Met Pro 
945                 950                 955                 960 


Ser Gln Arg Ala Arg Ser Phe Pro Leu Thr Arg Ser Gln Ser Cys Glu 
                965                 970                 975     


Thr Lys Leu Leu Asp Glu Lys Thr Ser Lys Leu Tyr Ser Ile Ser Ser 
            980                 985                 990         


Gln Val Ser Ser Ala Val Met Lys  Ser Leu Leu Cys Leu  Pro Ser Ser 
        995                 1000                 1005             


Ile Ser  Cys Ala Gln Thr Pro  Cys Ile Pro Lys Glu  Gly Ala Ser 
    1010                 1015                 1020             


Pro Thr  Ser Ser Ser Asn Glu  Asp Ser Ala Ala Asn  Gly Ser Ala 
    1025                 1030                 1035             


Glu Thr  Ser Ala Leu Asp Thr  Gly Phe Ser Leu Asn  Leu Ser Glu 
    1040                 1045                 1050             


Leu Arg  Glu Tyr Thr Glu Gly  Leu Thr Glu Ala Lys  Glu Asp Asp 
    1055                 1060                 1065             


Asp Gly  Asp His Ser Ser Leu  Gln Ser Gly Gln Ser  Val Ile Ser 
    1070                 1075                 1080             


Leu Leu  Ser Ser Glu Glu Leu  Lys Lys Leu Ile Glu  Glu Val Lys 
    1085                 1090                 1095             


Val Leu  Asp Glu Ala Thr Leu  Lys Gln Leu Asp Gly  Ile His Val 
    1100                 1105                 1110             


Thr Ile  Leu His Lys Glu Glu  Gly Ala Gly Leu Gly  Phe Ser Leu 
    1115                 1120                 1125             


Ala Gly  Gly Ala Asp Leu Glu  Asn Lys Val Ile Thr  Val His Arg 
    1130                 1135                 1140             


Val Phe  Pro Asn Gly Leu Ala  Ser Gln Glu Gly Thr  Ile Gln Lys 
    1145                 1150                 1155             


Gly Asn  Glu Val Leu Ser Ile  Asn Gly Lys Ser Leu  Lys Gly Thr 
    1160                 1165                 1170             


Thr His  His Asp Ala Leu Ala  Ile Leu Arg Gln Ala  Arg Glu Pro 
    1175                 1180                 1185             


Arg Gln  Ala Val Ile Val Thr  Arg Lys Leu Thr Pro  Glu Ala Met 
    1190                 1195                 1200             


Pro Asp  Leu Asn Ser Ser Thr  Asp Ser Ala Ala Ser  Ala Ser Ala 
    1205                 1210                 1215             


Ala Ser  Asp Val Ser Val Glu  Ser Thr Glu Ala Thr  Val Cys Thr 
    1220                 1225                 1230             


Val Thr  Leu Glu Lys Met Ser  Ala Gly Leu Gly Phe  Ser Leu Glu 
    1235                 1240                 1245             


Gly Gly  Lys Gly Ser Leu His  Gly Asp Lys Pro Leu  Thr Ile Asn 
    1250                 1255                 1260             


Arg Ile  Phe Lys Gly Ala Ala  Ser Glu Gln Ser Glu  Thr Val Gln 
    1265                 1270                 1275             


Pro Gly  Asp Glu Ile Leu Gln  Leu Gly Gly Thr Ala  Met Gln Gly 
    1280                 1285                 1290             


Leu Thr  Arg Phe Glu Ala Trp  Asn Ile Ile Lys Ala  Leu Pro Asp 
    1295                 1300                 1305             


Gly Pro  Val Thr Ile Val Ile  Arg Arg Lys Ser Leu  Gln Ser Lys 
    1310                 1315                 1320             


Glu Thr  Thr Ala Ala Gly Asp  Ser 
    1325                 1330     


<210>  33
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Asn Leu Pro Phe Pro Leu Lys Leu Leu Ser Ala Ser Ser Leu 
1               5                   10                  15      


Asn Thr Pro Ser Ser Thr Pro Trp Val Leu Asp Ile Phe Leu Thr Leu 
            20                  25                  30          


Val Phe Ala Leu Gly Phe Phe Phe Leu Leu Leu Pro Tyr Phe Ser Tyr 
        35                  40                  45              


Leu Arg Cys Asp Asn Pro Pro Ser Pro Ser Pro Lys Lys Arg Lys Arg 
    50                  55                  60                  


His Leu Val Ser Gln Arg Pro Ala Gly Arg Arg Gly Arg Pro Arg Gly 
65                  70                  75                  80  


Arg Met Lys Asn His Ser Leu Arg Ala Cys Arg Glu Cys Pro Arg Gly 
                85                  90                  95      


Leu Glu Glu Thr Trp Asp Leu Leu Ser Gln Leu Gln Ser Leu Leu Gly 
            100                 105                 110         


Pro His Leu Glu Lys Gly Asp Phe Gly Gln Leu Ser Gly Pro Asp Pro 
        115                 120                 125             


Pro Gly Glu Val Gly Lys Arg Thr Pro Asp Gly Ala Ser Arg Ser Ser 
    130                 135                 140                 


His Glu Pro Thr Glu Asp Ala Ala Pro Ile Val Ser Pro Leu Ala Ser 
145                 150                 155                 160 


Pro Asp Pro Arg Thr Lys His Pro Gln Asp Leu Ala Ser Thr Pro Pro 
                165                 170                 175     


Pro Gly Pro Met Thr Thr Ser Val Ser Ser Leu Ser Ala Ser Gln Pro 
            180                 185                 190         


Pro Glu Pro Ser Leu Leu Leu Glu His Pro Ser Pro Glu Pro Pro Ala 
        195                 200                 205             


Leu Phe Pro His Pro Pro Arg Thr Pro Asp Pro Leu Ala Cys Ser Pro 
    210                 215                 220                 


Pro Pro Pro Lys Gly Phe Thr Pro Pro Pro Leu Arg Asp Ser Thr Leu 
225                 230                 235                 240 


Leu Thr Pro Ser His Cys Asp Ser Val Ala Leu Pro Leu Asp Thr Val 
                245                 250                 255     


Pro Gln Ser Leu Ser Pro Arg Glu Asp Leu Ala Ala Ser Val Pro Gly 
            260                 265                 270         


Ile Ser Gly Leu Gly Gly Ser Asn Ser Gln Val Ser Ala Leu Ser Trp 
        275                 280                 285             


Ser Gln Glu Thr Thr Lys Thr Trp Cys Val Phe Asn Ser Ser Val Gln 
    290                 295                 300                 


Gln Asp His Leu Ser Arg Gln Arg Asp Thr Thr Met Ser Pro Leu Leu 
305                 310                 315                 320 


Phe Gln Ala Gln Pro Leu Ser His Leu Glu Pro Glu Ser Gln Pro Phe 
                325                 330                 335     


Ile Ser Ser Thr Pro Gln Phe Trp Pro Thr Pro Met Ala Gln Ala Glu 
            340                 345                 350         


Ala Gln Ala His Leu Gln Ser Ser Phe Pro Val Leu Ser Pro Ala Phe 
        355                 360                 365             


Leu Ser Pro Met Lys Asn Thr Gly Val Ala Cys Pro Ala Ser Gln Asn 
    370                 375                 380                 


Lys Val Gln Ala Leu Ser Leu Pro Glu Thr Gln His Pro Glu Arg Pro 
385                 390                 395                 400 


Leu Leu Lys Lys Gln Leu Glu Gly Gly Leu Ala Leu Pro Ser Arg Val 
                405                 410                 415     


Gln Lys Ser Gln Asp Val Phe Ser Val Ser Thr Pro Asn Leu Pro Gln 
            420                 425                 430         


Glu Arg Leu Thr Ser Ile Leu Pro Glu Asn Phe Pro Val Ser Pro Glu 
        435                 440                 445             


Leu Trp Arg Gln Leu Glu Gln His Met Gly Gln Arg Gly Arg Ile Gln 
    450                 455                 460                 


Glu Ser Leu Asp Leu Met Gln Leu Gln Asp Glu Leu Pro Gly Thr Ser 
465                 470                 475                 480 


Gln Ala Lys Gly Lys Pro Arg Pro Trp Gln Ser Ser Thr Ser Thr Gly 
                485                 490                 495     


Glu Ser Ser Lys Glu Ala Gln Thr Val Lys Phe Gln Leu Glu Arg Asp 
            500                 505                 510         


Pro Cys Pro His Leu Gly Gln Ile Leu Gly Glu Thr Pro Gln Asn Leu 
        515                 520                 525             


Ser Arg Gly Met Glu Ser Phe Pro Gly Lys Val Leu Gly Ala Thr Ser 
    530                 535                 540                 


Glu Glu Ser Glu Arg Asn Leu Arg Lys Pro Leu Arg Ser Asp Ser Gly 
545                 550                 555                 560 


Ser Asp Leu Leu Arg Arg Thr Glu Arg Asn His Ile Glu Asn Ile Leu 
                565                 570                 575     


Lys Ala His Met Ser Arg Lys Leu Gly Gln Thr Asn Glu Gly Leu Ile 
            580                 585                 590         


Pro Val Ser Val Arg Arg Ser Trp Leu Ala Val Asn Gln Ala Phe Pro 
        595                 600                 605             


Val Ser Asn Thr His Val Lys Thr Ser Asn Leu Ala Ala Pro Lys Ser 
    610                 615                 620                 


Arg Lys Ala Cys Val Asn Thr Ala Gln Val Leu Ser Phe Leu Glu Pro 
625                 630                 635                 640 


Cys Thr Gln Gln Val Leu Gly Ala His Ile Val Arg Phe Trp Ala Lys 
                645                 650                 655     


His Arg Trp Gly Leu Pro Leu Arg Val Leu Lys Pro Ile Gln Cys Phe 
            660                 665                 670         


Gln Leu Glu Lys Val Ser Ser Leu Ser Leu Ile Gln Leu Ala Gly Pro 
        675                 680                 685             


Ser Ser Asp Thr Cys Glu Ser Gly Ala Gly Ser Lys Val Glu Val Ala 
    690                 695                 700                 


Thr Phe Leu Gly Glu Pro Pro Met Ala Ser Leu Arg Lys Gln Val Leu 
705                 710                 715                 720 


Thr Lys Pro Ser Val His Met Pro Glu Arg Leu Gln Ala Ser Ser Pro 
                725                 730                 735     


Ala Cys Lys Gln Phe Gln Arg Ala Pro Arg Gly Ile Pro Ser Ser Asn 
            740                 745                 750         


Asp His Gly Ser Leu Lys Ala Pro Thr Ala Gly Gln Glu Gly Arg Trp 
        755                 760                 765             


Pro Ser Lys Pro Leu Thr Tyr Ser Leu Thr Gly Ser Thr Gln Gln Ser 
    770                 775                 780                 


Arg Ser Leu Gly Ala Gln Ser Ser Arg Ala Gly Glu Thr Arg Glu Ala 
785                 790                 795                 800 


Val Pro Gln Pro Thr Val Pro Leu Gly Thr Cys Met Arg Ala Asn Leu 
                805                 810                 815     


Gln Ala Thr Ser Glu Asp Val Arg Gly Phe Lys Ala Pro Gly Ala Ser 
            820                 825                 830         


Lys Ser Ser Leu Leu Pro Arg Met Ser Val Ser Gln Asp Pro Arg Lys 
        835                 840                 845             


Leu Cys Leu Met Glu Glu Ala Val Ser Glu Phe Glu Pro Gly Lys Ala 
    850                 855                 860                 


Thr Lys Ser Glu Thr Gln Pro Gln Val Ser Ala Thr Val Val Leu Leu 
865                 870                 875                 880 


Pro Asp Gly Gln Ala Ser Val Val Pro His Ala Ser Glu Asn Leu Ala 
                885                 890                 895     


Ser Gln Val Pro Gln Gly His Leu Gln Ser Met Pro Thr Gly Asn Met 
            900                 905                 910         


Gln Ala Ser Gln Glu Leu Cys Asp Leu Met Ser Ala Arg Arg Ser Asn 
        915                 920                 925             


Met Gly His Lys Glu Pro Arg Asn Pro Asn Cys Gln Gly Ser Cys Lys 
    930                 935                 940                 


Ser Gln Ser Pro Met Phe Pro Pro Thr His Lys Arg Glu Asn Ser Arg 
945                 950                 955                 960 


Lys Pro Asn Leu Glu Lys His Glu Glu Met Phe Gln Gly Leu Arg Thr 
                965                 970                 975     


Pro Gln Leu Thr Pro Gly Arg Lys Thr Glu Asp Thr Arg Gln Asn Glu 
            980                 985                 990         


Gly Val Gln Leu Leu Pro Ser Lys  Lys Gln Pro Pro Ser  Ile Ser His 
        995                 1000                 1005             


Phe Gly  Glu Asn Ile Lys Gln  Phe Phe Gln Thr Ile  Phe Ser Lys 
    1010                 1015                 1020             


Lys Glu  Arg Lys Pro Ala Pro  Val Thr Ala Glu Ser  Gln Lys Thr 
    1025                 1030                 1035             


Val Lys  Asn Arg Ser Cys Val  Tyr Gly Ser Ser Ala  Glu Ala Glu 
    1040                 1045                 1050             


Arg Leu  Met Thr Ala Val Gly  Gln Ile Leu Glu Glu  Asn Met Ser 
    1055                 1060                 1065             


Leu Cys  His Ala Arg His Ala  Ser Lys Val Asn Gln  Gln Arg Gln 
    1070                 1075                 1080             


Gln Phe  Gln Ala Pro Val Cys  Gly Phe Pro Cys Asn  His Arg His 
    1085                 1090                 1095             


Pro Phe  Tyr Ser Glu His Ser  Arg Met Leu Ser Tyr  Ala Ala Ser 
    1100                 1105                 1110             


Ser Gln  Gln Ala Thr Leu Lys  Asn Gln Ser Arg Pro  Asn Arg Asp 
    1115                 1120                 1125             


Arg Gln  Ile Arg Asp Gln 
    1130                 


<210>  34
<211>  962
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Glu Asp Cys Asn Val His Ser Ala Ala Ser Ile Leu Ala Ser Val 
1               5                   10                  15      


Lys Glu Gln Glu Ala Arg Phe Glu Arg Leu Thr Arg Ala Leu Glu Gln 
            20                  25                  30          


Glu Arg Arg His Val Ala Leu Gln Leu Glu Arg Ala Gln Gln Pro Gly 
        35                  40                  45              


Met Val Ser Gly Gly Met Gly Ser Gly Gln Pro Leu Pro Met Ala Trp 
    50                  55                  60                  


Gln Gln Leu Val Leu Gln Glu Gln Ser Pro Gly Ser Gln Ala Ser Leu 
65                  70                  75                  80  


Ala Thr Met Pro Glu Ala Pro Asp Val Leu Glu Glu Thr Val Thr Val 
                85                  90                  95      


Glu Glu Asp Pro Gly Thr Pro Thr Ser His Val Ser Ile Val Thr Ser 
            100                 105                 110         


Glu Asp Gly Thr Thr Arg Arg Thr Glu Thr Lys Val Thr Lys Thr Val 
        115                 120                 125             


Lys Thr Val Thr Thr Arg Thr Val Arg Gln Val Pro Val Gly Pro Asp 
    130                 135                 140                 


Gly Leu Pro Leu Leu Asp Gly Gly Pro Pro Leu Gly Pro Phe Ala Asp 
145                 150                 155                 160 


Gly Ala Leu Asp Arg His Phe Leu Leu Arg Gly Gly Gly Pro Val Ala 
                165                 170                 175     


Thr Leu Ser Arg Ala Tyr Leu Ser Ser Gly Gly Gly Phe Pro Glu Gly 
            180                 185                 190         


Pro Glu Pro Arg Asp Ser Pro Ser Tyr Gly Ser Leu Ser Arg Gly Leu 
        195                 200                 205             


Gly Met Arg Pro Pro Arg Ala Gly Pro Leu Gly Pro Gly Pro Gly Asp 
    210                 215                 220                 


Gly Cys Phe Thr Leu Pro Gly His Arg Glu Ala Phe Pro Val Gly Pro 
225                 230                 235                 240 


Glu Pro Gly Pro Pro Gly Gly Arg Ser Leu Pro Glu Arg Phe Gln Ala 
                245                 250                 255     


Glu Pro Tyr Gly Leu Glu Asp Asp Thr Arg Ser Leu Ala Ala Asp Asp 
            260                 265                 270         


Glu Gly Gly Pro Glu Leu Glu Pro Asp Tyr Gly Thr Ala Thr Arg Arg 
        275                 280                 285             


Arg Pro Glu Cys Gly Arg Gly Leu His Thr Arg Ala Tyr Glu Asp Thr 
    290                 295                 300                 


Ala Asp Asp Gly Gly Glu Leu Ala Asp Glu Arg Pro Ala Phe Pro Met 
305                 310                 315                 320 


Val Thr Ala Pro Leu Ala Gln Pro Glu Arg Gly Ser Met Gly Ser Leu 
                325                 330                 335     


Asp Arg Leu Val Arg Arg Ser Pro Ser Val Asp Ser Ala Arg Lys Glu 
            340                 345                 350         


Pro Arg Trp Arg Asp Pro Glu Leu Pro Glu Val Leu Ala Met Leu Arg 
        355                 360                 365             


His Pro Val Asp Pro Val Lys Ala Asn Ala Ala Ala Tyr Leu Gln His 
    370                 375                 380                 


Leu Cys Phe Glu Asn Glu Gly Val Lys Arg Arg Val Arg Gln Leu Arg 
385                 390                 395                 400 


Gly Leu Pro Leu Leu Val Ala Leu Leu Asp His Pro Arg Ala Glu Val 
                405                 410                 415     


Arg Arg Arg Ala Cys Gly Ala Leu Arg Asn Leu Ser Tyr Gly Arg Asp 
            420                 425                 430         


Thr Asp Asn Lys Ala Ala Ile Arg Asp Cys Gly Gly Val Pro Ala Leu 
        435                 440                 445             


Val Arg Leu Leu Arg Ala Ala Arg Asp Asn Glu Val Arg Glu Leu Val 
    450                 455                 460                 


Thr Gly Thr Leu Trp Asn Leu Ser Ser Tyr Glu Pro Leu Lys Met Val 
465                 470                 475                 480 


Ile Ile Asp His Gly Leu Gln Thr Leu Thr His Glu Val Ile Val Pro 
                485                 490                 495     


His Ser Gly Trp Glu Arg Glu Pro Asn Glu Asp Ser Lys Pro Arg Asp 
            500                 505                 510         


Ala Glu Trp Thr Thr Val Phe Lys Asn Thr Ser Gly Cys Leu Arg Asn 
        515                 520                 525             


Val Ser Ser Asp Gly Ala Glu Ala Arg Arg Arg Leu Arg Glu Cys Glu 
    530                 535                 540                 


Gly Leu Val Asp Ala Leu Leu His Ala Leu Gln Ser Ala Val Gly Arg 
545                 550                 555                 560 


Lys Asp Thr Asp Asn Lys Ser Val Glu Asn Cys Val Cys Ile Met Arg 
                565                 570                 575     


Asn Leu Ser Tyr His Val His Lys Glu Val Pro Gly Ala Asp Arg Tyr 
            580                 585                 590         


Gln Glu Ala Glu Pro Gly Pro Leu Gly Ser Ala Val Gly Ser Gln Arg 
        595                 600                 605             


Arg Arg Arg Asp Asp Ala Ser Cys Phe Gly Gly Lys Lys Ala Lys Glu 
    610                 615                 620                 


Glu Trp Phe His Gln Gly Lys Lys Asp Gly Glu Met Asp Arg Asn Phe 
625                 630                 635                 640 


Asp Thr Leu Asp Leu Pro Lys Arg Thr Glu Ala Ala Lys Gly Phe Glu 
                645                 650                 655     


Leu Leu Tyr Gln Pro Glu Val Val Arg Leu Tyr Leu Ser Leu Leu Thr 
            660                 665                 670         


Glu Ser Arg Asn Phe Asn Thr Leu Glu Ala Ala Ala Gly Ala Leu Gln 
        675                 680                 685             


Asn Leu Ser Ala Gly Asn Trp Met Trp Ala Thr Tyr Ile Arg Ala Thr 
    690                 695                 700                 


Val Arg Lys Glu Arg Gly Leu Pro Val Leu Val Glu Leu Leu Gln Ser 
705                 710                 715                 720 


Glu Thr Asp Lys Val Val Arg Ala Val Ala Ile Ala Leu Arg Asn Leu 
                725                 730                 735     


Ser Leu Asp Arg Arg Asn Lys Asp Leu Ile Gly Ser Tyr Ala Met Ala 
            740                 745                 750         


Glu Leu Val Arg Asn Val Arg Asn Ala Gln Ala Pro Pro Arg Pro Gly 
        755                 760                 765             


Ala Cys Leu Glu Glu Asp Thr Val Val Ala Val Leu Asn Thr Ile His 
    770                 775                 780                 


Glu Ile Val Ser Asp Ser Leu Asp Asn Ala Arg Ser Leu Leu Gln Ala 
785                 790                 795                 800 


Arg Gly Val Pro Ala Leu Val Ala Leu Val Ala Ser Ser Gln Ser Val 
                805                 810                 815     


Arg Glu Ala Lys Ala Ala Ser His Val Leu Gln Thr Val Trp Ser Tyr 
            820                 825                 830         


Lys Glu Leu Arg Gly Thr Leu Gln Lys Asp Gly Trp Thr Lys Ala Arg 
        835                 840                 845             


Phe Gln Ser Ala Ala Ala Thr Ala Lys Gly Pro Lys Gly Ala Leu Ser 
    850                 855                 860                 


Pro Gly Gly Phe Asp Asp Ser Thr Leu Pro Leu Val Asp Lys Ser Leu 
865                 870                 875                 880 


Glu Gly Glu Lys Thr Gly Ser Arg Asp Val Ile Pro Met Asp Ala Leu 
                885                 890                 895     


Gly Pro Asp Gly Tyr Ser Thr Val Asp Arg Arg Glu Arg Arg Pro Arg 
            900                 905                 910         


Gly Ala Ser Ser Ala Gly Glu Ala Ser Glu Lys Glu Pro Leu Lys Leu 
        915                 920                 925             


Asp Pro Ser Arg Lys Ala Pro Pro Pro Gly Pro Ser Arg Pro Ala Val 
    930                 935                 940                 


Arg Leu Val Asp Ala Val Gly Asp Ala Lys Pro Gln Pro Val Asp Ser 
945                 950                 955                 960 


Trp Val 
        


<210>  35
<211>  2261
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      


Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          


Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              


Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      


Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         


Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             


Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 


Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 


Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     


Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         


Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             


Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 


Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 


Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     


Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         


Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             


Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 


Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 


Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     


Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         


Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             


Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 


Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 


Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     


Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         


Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             


Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 


Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 


Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     


Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         


Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             


Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 


Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 


Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     


Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         


Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             


Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 


Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 


Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     


Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         


Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             


Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 


Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 


Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     


Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         


Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             


Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 


Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 


Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     


Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         


Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             


Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 


Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 


Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     


Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         


Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             


Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 


Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 


Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     


Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         


His Ile Trp Phe Tyr Ala Arg Leu  Lys Gly Leu Ser Glu  Lys His Val 
        995                 1000                 1005             


Lys Ala  Glu Met Glu Gln Met  Ala Leu Asp Val Gly  Leu Pro Ser 
    1010                 1015                 1020             


Ser Lys  Leu Lys Ser Lys Thr  Ser Gln Leu Ser Gly  Gly Met Gln 
    1025                 1030                 1035             


Arg Lys  Leu Ser Val Ala Leu  Ala Phe Val Gly Gly  Ser Lys Val 
    1040                 1045                 1050             


Val Ile  Leu Asp Glu Pro Thr  Ala Gly Val Asp Pro  Tyr Ser Arg 
    1055                 1060                 1065             


Arg Gly  Ile Trp Glu Leu Leu  Leu Lys Tyr Arg Gln  Gly Arg Thr 
    1070                 1075                 1080             


Ile Ile  Leu Ser Thr His His  Met Asp Glu Ala Asp  Val Leu Gly 
    1085                 1090                 1095             


Asp Arg  Ile Ala Ile Ile Ser  His Gly Lys Leu Cys  Cys Val Gly 
    1100                 1105                 1110             


Ser Ser  Leu Phe Leu Lys Asn  Gln Leu Gly Thr Gly  Tyr Tyr Leu 
    1115                 1120                 1125             


Thr Leu  Val Lys Lys Asp Val  Glu Ser Ser Leu Ser  Ser Cys Arg 
    1130                 1135                 1140             


Asn Ser  Ser Ser Thr Val Ser  Tyr Leu Lys Lys Glu  Asp Ser Val 
    1145                 1150                 1155             


Ser Gln  Ser Ser Ser Asp Ala  Gly Leu Gly Ser Asp  His Glu Ser 
    1160                 1165                 1170             


Asp Thr  Leu Thr Ile Asp Val  Ser Ala Ile Ser Asn  Leu Ile Arg 
    1175                 1180                 1185             


Lys His  Val Ser Glu Ala Arg  Leu Val Glu Asp Ile  Gly His Glu 
    1190                 1195                 1200             


Leu Thr  Tyr Val Leu Pro Tyr  Glu Ala Ala Lys Glu  Gly Ala Phe 
    1205                 1210                 1215             


Val Glu  Leu Phe His Glu Ile  Asp Asp Arg Leu Ser  Asp Leu Gly 
    1220                 1225                 1230             


Ile Ser  Ser Tyr Gly Ile Ser  Glu Thr Thr Leu Glu  Glu Ile Phe 
    1235                 1240                 1245             


Leu Lys  Val Ala Glu Glu Ser  Gly Val Asp Ala Glu  Thr Ser Asp 
    1250                 1255                 1260             


Gly Thr  Leu Pro Ala Arg Arg  Asn Arg Arg Ala Phe  Gly Asp Lys 
    1265                 1270                 1275             


Gln Ser  Cys Leu Arg Pro Phe  Thr Glu Asp Asp Ala  Ala Asp Pro 
    1280                 1285                 1290             


Asn Asp  Ser Asp Ile Asp Pro  Glu Ser Arg Glu Thr  Asp Leu Leu 
    1295                 1300                 1305             


Ser Gly  Met Asp Gly Lys Gly  Ser Tyr Gln Val Lys  Gly Trp Lys 
    1310                 1315                 1320             


Leu Thr  Gln Gln Gln Phe Val  Ala Leu Leu Trp Lys  Arg Leu Leu 
    1325                 1330                 1335             


Ile Ala  Arg Arg Ser Arg Lys  Gly Phe Phe Ala Gln  Ile Val Leu 
    1340                 1345                 1350             


Pro Ala  Val Phe Val Cys Ile  Ala Leu Val Phe Ser  Leu Ile Val 
    1355                 1360                 1365             


Pro Pro  Phe Gly Lys Tyr Pro  Ser Leu Glu Leu Gln  Pro Trp Met 
    1370                 1375                 1380             


Tyr Asn  Glu Gln Tyr Thr Phe  Val Ser Asn Asp Ala  Pro Glu Asp 
    1385                 1390                 1395             


Thr Gly  Thr Leu Glu Leu Leu  Asn Ala Leu Thr Lys  Asp Pro Gly 
    1400                 1405                 1410             


Phe Gly  Thr Arg Cys Met Glu  Gly Asn Pro Ile Pro  Asp Thr Pro 
    1415                 1420                 1425             


Cys Gln  Ala Gly Glu Glu Glu  Trp Thr Thr Ala Pro  Val Pro Gln 
    1430                 1435                 1440             


Thr Ile  Met Asp Leu Phe Gln  Asn Gly Asn Trp Thr  Met Gln Asn 
    1445                 1450                 1455             


Pro Ser  Pro Ala Cys Gln Cys  Ser Ser Asp Lys Ile  Lys Lys Met 
    1460                 1465                 1470             


Leu Pro  Val Cys Pro Pro Gly  Ala Gly Gly Leu Pro  Pro Pro Gln 
    1475                 1480                 1485             


Arg Lys  Gln Asn Thr Ala Asp  Ile Leu Gln Asp Leu  Thr Gly Arg 
    1490                 1495                 1500             


Asn Ile  Ser Asp Tyr Leu Val  Lys Thr Tyr Val Gln  Ile Ile Ala 
    1505                 1510                 1515             


Lys Ser  Leu Lys Asn Lys Ile  Trp Val Asn Glu Phe  Arg Tyr Gly 
    1520                 1525                 1530             


Gly Phe  Ser Leu Gly Val Ser  Asn Thr Gln Ala Leu  Pro Pro Ser 
    1535                 1540                 1545             


Gln Glu  Val Asn Asp Ala Ile  Lys Gln Met Lys Lys  His Leu Lys 
    1550                 1555                 1560             


Leu Ala  Lys Asp Ser Ser Ala  Asp Arg Phe Leu Asn  Ser Leu Gly 
    1565                 1570                 1575             


Arg Phe  Met Thr Gly Leu Asp  Thr Lys Asn Asn Val  Lys Val Trp 
    1580                 1585                 1590             


Phe Asn  Asn Lys Gly Trp His  Ala Ile Ser Ser Phe  Leu Asn Val 
    1595                 1600                 1605             


Ile Asn  Asn Ala Ile Leu Arg  Ala Asn Leu Gln Lys  Gly Glu Asn 
    1610                 1615                 1620             


Pro Ser  His Tyr Gly Ile Thr  Ala Phe Asn His Pro  Leu Asn Leu 
    1625                 1630                 1635             


Thr Lys  Gln Gln Leu Ser Glu  Val Ala Leu Met Thr  Thr Ser Val 
    1640                 1645                 1650             


Asp Val  Leu Val Ser Ile Cys  Val Ile Phe Ala Met  Ser Phe Val 
    1655                 1660                 1665             


Pro Ala  Ser Phe Val Val Phe  Leu Ile Gln Glu Arg  Val Ser Lys 
    1670                 1675                 1680             


Ala Lys  His Leu Gln Phe Ile  Ser Gly Val Lys Pro  Val Ile Tyr 
    1685                 1690                 1695             


Trp Leu  Ser Asn Phe Val Trp  Asp Met Cys Asn Tyr  Val Val Pro 
    1700                 1705                 1710             


Ala Thr  Leu Val Ile Ile Ile  Phe Ile Cys Phe Gln  Gln Lys Ser 
    1715                 1720                 1725             


Tyr Val  Ser Ser Thr Asn Leu  Pro Val Leu Ala Leu  Leu Leu Leu 
    1730                 1735                 1740             


Leu Tyr  Gly Trp Ser Ile Thr  Pro Leu Met Tyr Pro  Ala Ser Phe 
    1745                 1750                 1755             


Val Phe  Lys Ile Pro Ser Thr  Ala Tyr Val Val Leu  Thr Ser Val 
    1760                 1765                 1770             


Asn Leu  Phe Ile Gly Ile Asn  Gly Ser Val Ala Thr  Phe Val Leu 
    1775                 1780                 1785             


Glu Leu  Phe Thr Asp Asn Lys  Leu Asn Asn Ile Asn  Asp Ile Leu 
    1790                 1795                 1800             


Lys Ser  Val Phe Leu Ile Phe  Pro His Phe Cys Leu  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ile  Asp Met Val Lys Asn  Gln Ala Met Ala Asp  Ala Leu Glu 
    1820                 1825                 1830             


Arg Phe  Gly Glu Asn Arg Phe  Val Ser Pro Leu Ser  Trp Asp Leu 
    1835                 1840                 1845             


Val Gly  Arg Asn Leu Phe Ala  Met Ala Val Glu Gly  Val Val Phe 
    1850                 1855                 1860             


Phe Leu  Ile Thr Val Leu Ile  Gln Tyr Arg Phe Phe  Ile Arg Pro 
    1865                 1870                 1875             


Arg Pro  Val Asn Ala Lys Leu  Ser Pro Leu Asn Asp  Glu Asp Glu 
    1880                 1885                 1890             


Asp Val  Arg Arg Glu Arg Gln  Arg Ile Leu Asp Gly  Gly Gly Gln 
    1895                 1900                 1905             


Asn Asp  Ile Leu Glu Ile Lys  Glu Leu Thr Lys Ile  Tyr Arg Arg 
    1910                 1915                 1920             


Lys Arg  Lys Pro Ala Val Asp  Arg Ile Cys Val Gly  Ile Pro Pro 
    1925                 1930                 1935             


Gly Glu  Cys Phe Gly Leu Leu  Gly Val Asn Gly Ala  Gly Lys Ser 
    1940                 1945                 1950             


Ser Thr  Phe Lys Met Leu Thr  Gly Asp Thr Thr Val  Thr Arg Gly 
    1955                 1960                 1965             


Asp Ala  Phe Leu Asn Lys Asn  Ser Ile Leu Ser Asn  Ile His Glu 
    1970                 1975                 1980             


Val His  Gln Asn Met Gly Tyr  Cys Pro Gln Phe Asp  Ala Ile Thr 
    1985                 1990                 1995             


Glu Leu  Leu Thr Gly Arg Glu  His Val Glu Phe Phe  Ala Leu Leu 
    2000                 2005                 2010             


Arg Gly  Val Pro Glu Lys Glu  Val Gly Lys Val Gly  Glu Trp Ala 
    2015                 2020                 2025             


Ile Arg  Lys Leu Gly Leu Val  Lys Tyr Gly Glu Lys  Tyr Ala Gly 
    2030                 2035                 2040             


Asn Tyr  Ser Gly Gly Asn Lys  Arg Lys Leu Ser Thr  Ala Met Ala 
    2045                 2050                 2055             


Leu Ile  Gly Gly Pro Pro Val  Val Phe Leu Asp Glu  Pro Thr Thr 
    2060                 2065                 2070             


Gly Met  Asp Pro Lys Ala Arg  Arg Phe Leu Trp Asn  Cys Ala Leu 
    2075                 2080                 2085             


Ser Val  Val Lys Glu Gly Arg  Ser Val Val Leu Thr  Ser His Ser 
    2090                 2095                 2100             


Met Glu  Glu Cys Glu Ala Leu  Cys Thr Arg Met Ala  Ile Met Val 
    2105                 2110                 2115             


Asn Gly  Arg Phe Arg Cys Leu  Gly Ser Val Gln His  Leu Lys Asn 
    2120                 2125                 2130             


Arg Phe  Gly Asp Gly Tyr Thr  Ile Val Val Arg Ile  Ala Gly Ser 
    2135                 2140                 2145             


Asn Pro  Asp Leu Lys Pro Val  Gln Asp Phe Phe Gly  Leu Ala Phe 
    2150                 2155                 2160             


Pro Gly  Ser Val Leu Lys Glu  Lys His Arg Asn Met  Leu Gln Tyr 
    2165                 2170                 2175             


Gln Leu  Pro Ser Ser Leu Ser  Ser Leu Ala Arg Ile  Phe Ser Ile 
    2180                 2185                 2190             


Leu Ser  Gln Ser Lys Lys Arg  Leu His Ile Glu Asp  Tyr Ser Val 
    2195                 2200                 2205             


Ser Gln  Thr Thr Leu Asp Gln  Val Phe Val Asn Phe  Ala Lys Asp 
    2210                 2215                 2220             


Gln Ser  Asp Asp Asp His Leu  Lys Asp Leu Ser Leu  His Lys Asn 
    2225                 2230                 2235             


Gln Thr  Val Val Asp Val Ala  Val Leu Thr Ser Phe  Leu Gln Asp 
    2240                 2245                 2250             


Glu Lys  Val Lys Glu Ser Tyr  Val 
    2255                 2260     


<210>  36
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


