                         SEQUENCE LISTING

<110>  Lentigen Technology, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-BCMA 
       IMMUNOTHERAPY

<130>  42449-0044WO1

<150>  US 62/854,574
<151>  2019-05-30

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  727
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-1

<400>  1
gaggtgcagc tggtggagac tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgatgac acggctgtgt attactgtgc gagagattgg      300

gagggctatg agggaggggt gaaatggggc cagggcaccc tggtcaccgt ctcctcagga      360

ggtggcggat ctggtggagg cggtagcggt ggtggcggat cccgaaattg tgctgactca      420

gtctccatcc tccctgtctg catctgtagg agacagagtc accatcactt gccaggcgag      480

tcaggacatt agcaactatt taaattggta tcagcagaaa ccagggaaag cccctaagct      540

cctgatctac gatgcatcca atttggaaac aggggtccca tcaaggttca gtggaagtgg      600

atctgggaca gattttactt tcaccatcag cagcctgcag cctgaagata ttgcaacata      660

ttactgtcaa cagtatgata atctctcgta cacttttggc caggggacca agctggagat      720

caaacgt                                                                727


<210>  2
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-1

<400>  2

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Glu Gly Tyr Glu Gly Gly Val Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  3
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-2

<400>  3
gaggtgcagc tggtgcaatc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaggt attaatggga gtggcgatag aacatattac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctctat      240

ctgcaaatga acagcctgag agccgaagac acggccgtat attactgtgc gaactataat      300

tacgatgata atagtggtta tggcctgggc cagggaaccc tggtcaccgt ctcctcagga      360

ggtggcggat ctggtggagg cggtagcggt ggtggcggat cccagtctgt gctgactcag      420

ccaccctcgg tgtcagtggc cccaggaaag acggccagga ttacctgtgg gggaaacaac      480

attggaagta aaagtgtgca ctggtaccag cagaagccag gccaggcccc tgtgctggtc      540

atctatgatg atagcgaccg gccctcaggg atccctgagc gattctctgg ctccaactct      600

gggaacacag ccaccctgac catcagcagg gtcgaagccg gggatgaagc cgactattac      660

tgtcaggtgt gggacagtag tagtgatcat tgggtgttcg gcggagggac caaggtcacc      720

gtcctaggt                                                              729


<210>  4
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-2

<400>  4

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Gly Ser Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Asn Tyr Asp Asp Asn Ser Gly Tyr Gly Leu Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Val Ala Pro Gly Lys Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn 
145                 150                 155                 160 


Ile Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp 
    210                 215                 220                 


Asp Ser Ser Ser Asp His Trp Val Phe Gly Gly Gly Thr Lys Val Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  5
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-3

<400>  5
gaggtgcagc tggtggagtc cgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag catctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagacgac      300

tacggtggta actccgaggg tgactactgg ggccagggaa ccctggtcac cgtctcctca      360

ggaggtggcg gatctggtgg aggcggtagc ggtggtggcg gatccgaaat tgtgttgaca      420

cagtctccag ccaccctgtc tgtgtctcta ggagagagag ccaccctctc ctgcagggcc      480

agtcagagtg ttagcaacag cttagcctgg tatcagcaga aacctggcca ggctcccagg      540

ctcctcatct atgatgcatc cacgagggcc actggcatcc cagccaggtt cagtggcagt      600

gggtctggga cagagttcac tctcaccatc agcagtctgc agcctgaaga ttttgcaact      660

tatttctgtc aacagactta cagtcccccg atcaccttcg gccaagggac acgactggag      720

attaaacga                                                              729


<210>  6
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-3

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Asp Tyr Gly Gly Asn Ser Glu Gly Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Thr Leu Ser Val Ser Leu Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Val Ser Asn Ser Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Asp Ala Ser Thr Arg Ala Thr Gly 
            180                 185                 190         


Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  7
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-4

<400>  7
gaggtgcagc tggtggagac tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgatgac acggctgtgt attactgtgc gagagattgg      300

gagggctatg agggaggggt gaaatggggc cagggcaccc tggtcaccgt ctcctcagga      360

ggtggcggat ctggtggagg cggtagcggt ggtggcggat ccgaaattgt gctgactcag      420

tctccatcct ccctgtctgc atctgtagga gacagagtca ccatcacttg ccaggcgagt      480

caggacatta gcaactattt aaattggtat cagcagaaac cagggaaagc ccctaagctc      540

ctgatctacg atgcatccaa tttggaaaca ggggtcccat caaggttcag tggaagtgga      600

tctgggacag attttacttt caccatcagc agcctgcagc ctgaagatat tgcaacatat      660

tactgtcaac agtatgataa tctctcgtac acttttggcc aggggaccaa gctggagatc      720

aaacgt                                                                 726


<210>  8
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-4

<400>  8

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Glu Gly Tyr Glu Gly Gly Val Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser 
145                 150                 155                 160 


Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys 
                165                 170                 175     


Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val 
            180                 185                 190         


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
        195                 200                 205             


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Tyr Asp Asn Leu Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys Arg 
        


<210>  9
<211>  753
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MB-5

<400>  9
gaggtccagc tggtgcagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagattgg      300

gccggggatt gtactaatgg ccaatgcggc gtctactggg gccagggaac cctggtcacc      360

gtctcctcag gaggtggcgg atctggtgga ggcggtagcg gtggtggcgg atccgaaatt      420

gtgttgacgc agtctccact ctccctgccc gtcacccctg gagagccggc ctccatctcc      480

tgcaggtcta gtcagagcct cctgcatagt aatggataca actatttgga ttggtacctg      540

cagaagccag ggcagtctcc acagctcctg atctatttgg gttctaatcg ggcctccggg      600

gtccctgaca ggttcagtgg cagtggatca ggcacagatt ttacactgaa aatcagcaga      660

gtggaggctg aggatgttgg ggtttattac tgcatgcaag ctctacaaac tccgtacact      720

tttggccagg ggaccaagct ggagatcaaa cgt                                   753


<210>  10
<211>  251
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-5

<400>  10

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Trp Ala Gly Asp Cys Thr Asn Gly Gln Cys Gly Val Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 
    130                 135                 140                 


Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu 
                165                 170                 175     


Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr 
            180                 185                 190         


Leu Gly Ser Asn Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Val Gly Val Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Tyr Thr 
225                 230                 235                 240 


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
                245                 250     


<210>  11
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-14

<400>  11
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt gagcgatgac      300

tacggtggta actccgggac tagctactgg ggccagggaa ccctggtcac cgtctcctca      360

ggaggtggcg gatctggtgg aggcggtagc ggtggtggcg gatccgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccaggcg      480

agtcaggaca ttagcaacta tttaaattgg tatcagcaga agccagggaa agcccctaag      540

ctcctgatct acgatgcatc caatttggaa acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtaccccc gtgacgttcg gcggagggac caagctgacc      720

gtcctaggt                                                              729


<210>  12
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-14

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Asp Asp Tyr Gly Gly Asn Ser Gly Thr Ser Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Val Thr Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  13
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  leader/signal peptide sequence

<400>  13
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  14
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  leader/signal peptide sequence

<400>  14

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  15
<211>  735
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-15

<400>  15
caggtgcagc tggtggagac cgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagattgg      300

gattgtactg gtggtgtatg cccccttggg ggctggggcc agggaaccct ggtcaccgtc      360

tcctcaggag gtggcggatc tggtggaggc ggtagcggtg gtggcggatc cgacatccag      420

ttgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      480

cgggcaagtc agagcattag tggctattta aattggtatc agcagaaacc agggaaagcc      540

cctaagctcc tgatctatgc tgcatccagt ttgcaaagtg gggtcccatc aaggttcagt      600

ggcagtggat ctgggacaga gttcactctc accatcagca gtctgcagcc tgaagatttt      660

gcaacttatt tctgtcaaca gacttacagt cccccgatca ccttcggcca agggacacga      720

ctggagatta aacga                                                       735


<210>  16
<211>  245
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-15

<400>  16

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Asp Cys Thr Gly Gly Val Cys Pro Leu Gly Gly Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Gly Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg 
225                 230                 235                 240 


Leu Glu Ile Lys Arg 
                245 


<210>  17
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-16

<400>  17
gaggtccagc tggtgcagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagacctt      300

aatgactacg gtgacccgcc cccttactgg ggccagggaa ccctggtcac cgtctcctca      360

ggaggtggcg gatctggtgg aggcggtagc ggtggtggcg gatccgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccgggca      480

agtcagagca ttagcagcta tttaaattgg tatcagcaga aaccagggaa agcccctaag      540

ctcctgatct acgatgcatc caatttggaa acaggggtct catcaaggtt cagtggcagt      600

ggatctggga cagagttcac tctcaccatc agcagtctgc agcctgaaga ttttgcaact      660

tatttctgtc aacagactta cagtcccccg atcaccttcg gccaagggac acgactggag      720

attaaacga                                                              729


<210>  18
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-16

<400>  18

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Asn Asp Tyr Gly Asp Pro Pro Pro Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
145                 150                 155                 160 


Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly 
            180                 185                 190         


Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln 
    210                 215                 220                 


Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu 
225                 230                 235                 240 


Ile Lys Arg 
            


<210>  19
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-25

<400>  19
gaggtgcagc tggtggagtc cgggggaggc ttagttcagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatctc      300

gaaatgactg actactgggg ccagggaacc ctggtcaccg tctcctcagg aggtggcgga      360

tctggtggag gcggtagcgg tggtggcgga tccgaaattg tgctgactca gtctccactc      420

tccctgcccg tcacccctgg agagccggcc tccatatttt gtaggtctag tcagagtctc      480

ctgcatgaaa atggatacaa ctatttggat tggtacctgc agaagccagg gcagtctcca      540

cagctcctga tctatttggg ttctaatcgg gcctccgggg tccctgacag gttcagtggc      600

agtggatcag gcacagattt tacactgaaa atcagcagag tggaggctga ggatgttggg      660

gtttattact gcatgcaagc tctacaaacc cctcgaactt ttggccaggg gaccaagctg      720

gaaaccaaac gt                                                          732


<210>  20
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-25

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Glu Met Thr Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val 
    130                 135                 140                 


Thr Pro Gly Glu Pro Ala Ser Ile Phe Cys Arg Ser Ser Gln Ser Leu 
145                 150                 155                 160 


Leu His Glu Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro 
                165                 170                 175     


Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
    210                 215                 220                 


Met Gln Ala Leu Gln Thr Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Thr Lys Arg 
                


<210>  21
<211>  750
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-28

<400>  21
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagattcg      300

tatagcagca gcggggaccc ccgggcgttc gacccctggg gccagggaac cctggtcacc      360

gtctcctcag gaggtggcgg atctggtgga ggcggtagcg gtggtggcgg atccaatttt      420

atgctgactc agccccactc tgtgtcggag tctccgggga agacggtaac catctcctgc      480

accggcagca gtggcagcat tgccagcaac tatgtgcagt ggtaccagca gcgcccgggc      540

agtgccccct ccactgtcat ctttgaggat aaccaaagac cctctggggt ccctggtcgg      600

ttctctggct ccgtcgacag gtcctccaac tctgcctccc tcaccatctc tggactgaag      660

actgaggacg aggctgacta ctattgtcag tcttatgata gcaacaatcg gggtctgttc      720

ggcggaggga ccaaggtcac cgtcctaggt                                       750


<210>  22
<211>  250
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-28

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Ser Tyr Ser Ser Ser Gly Asp Pro Arg Ala Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asn Phe Met Leu Thr Gln 
    130                 135                 140                 


Pro His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys 
145                 150                 155                 160 


Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln 
                165                 170                 175     


Gln Arg Pro Gly Ser Ala Pro Ser Thr Val Ile Phe Glu Asp Asn Gln 
            180                 185                 190         


Arg Pro Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Val Asp Arg Ser 
        195                 200                 205             


Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn Asn Arg Gly Leu Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
                245                 250 


<210>  23
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-37

<400>  23
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagattgg      300

gaatatagtg gctacgatgc ccacccgggg tggggccagg gaaccctggt caccgtctcc      360

tcaggaggtg gcggatctgg tggaggcggt agcggtggtg gcggatccga catccagttg      420

acccagtctc catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg      480

gcaagtcagg gcattagcag tgctttagcc tggtatcagc agaaaccagg gaaagctcct      540

aagctcctga tctatgatgc ctccagtttg gaaagtgggg tcccatcaag gttcagtggc      600

agtggatctg ggacagagtt cactctcacc atcagcagtc tgcagcctga agattttgca      660

acttatttct gtcaacagac ttacagtccc ccgatcacct tcggccaagg gacacgactg      720

gagattaaac ga                                                          732


<210>  24
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-37

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Glu Tyr Ser Gly Tyr Asp Ala His Pro Gly Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Ser Leu Glu Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu 
225                 230                 235                 240 


Glu Ile Lys Arg 
                


<210>  25
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-39

<400>  25
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatggg      300

gctcggaatg attactgggg ccagggcacc ctggtcaccg tctcctcagg aggtggcgga      360

tctggtggag gcggtagcgg tggtggcgga tccaatttta tgctgactca gccccactct      420

gtgtcggagt ctccggggaa gacggtaacc atctcctgca cccgcagcag tggcagcatt      480

gccagcaact atgtgcagtg gtaccagcag cgcccgggca gtgcccccac cactgtgatc      540

tatgaggata accaaagacc ctctggggtc cctgatcggt tctctggctc catcgacagc      600

tcctccaact ctgcctccct caccatctct ggactgaaga ctgaggacga ggctgactac      660

tactgtcaga cttatgatga caacaatcat gtcattttcg gcggagggac ccagctcacc      720

gttttaggt                                                              729


<210>  26
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-39

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ala Arg Asn Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser 
    130                 135                 140                 


Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile 
145                 150                 155                 160 


Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro 
                165                 170                 175     


Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr 
        195                 200                 205             


Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr 
    210                 215                 220                 


Tyr Asp Asp Asn Asn His Val Ile Phe Gly Gly Gly Thr Gln Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  27
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 transmembrane domain

<400>  27
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc       60

accctttact gc                                                           72


<210>  28
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 transmembrane domain

<400>  28

Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
1               5                   10                  15      


Val Ile Thr Leu Tyr Cys 
            20          


<210>  29
<211>  135
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 hinge domain

<400>  29
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  30
<211>  47
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 hinge domain

<400>  30

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        35                  40                  45          


<210>  31
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  32
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  33
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  signaling domain of 4-1BB

<400>  33
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  34
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  signaling domain of 4-1BB

<400>  34

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  35
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  signaling domain of CD3-zeta

<400>  35
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggtctca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  36
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3zeta

<400>  36

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  37
<211>  726
<212>  DNA
<213>  Artificial

<220>
<223>  ScFv CD 19

<400>  37
gacatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt aaatatttaa attggtatca gcagaaacca      120

gatggaactg ttaaactcct gatctaccat acatcaagat tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccgtacac gttcggaggg      300

gggaccaagc tggagatcac aggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctgagg tgaaactgca ggagtcagga cctggcctgg tggcgccctc acagagcctg      420

tccgtcacat gcactgtctc aggggtctca ttacccgact atggtgtaag ctggattcgc      480

cagcctccac gaaagggtct ggagtggctg ggagtaatat ggggtagtga aaccacatac      540

tataattcag ctctcaaatc cagactgacc atcatcaagg acaactccaa gagccaagtt      600

ttcttaaaaa tgaacagtct gcaaactgat gacacagcca tttactactg tgccaaacat      660

tattactacg gtggtagcta tgctatggac tactggggcc aaggaacctc agtcaccgtc      720

tcctca                                                                 726


<210>  38
<211>  242
<212>  PRT
<213>  Artificial

<220>
<223>  ScFv CD 19

<400>  38

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr His Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Thr Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Lys Leu Gln Glu 
        115                 120                 125             


Ser Gly Pro Gly Leu Val Ala Pro Ser Gln Ser Leu Ser Val Thr Cys 
    130                 135                 140                 


Thr Val Ser Gly Val Ser Leu Pro Asp Tyr Gly Val Ser Trp Ile Arg 
145                 150                 155                 160 


Gln Pro Pro Arg Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Gly Ser 
                165                 170                 175     


Glu Thr Thr Tyr Tyr Asn Ser Ala Leu Lys Ser Arg Leu Thr Ile Ile 
            180                 185                 190         


Lys Asp Asn Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln 
        195                 200                 205             


Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Lys His Tyr Tyr Tyr Gly 
    210                 215                 220                 


Gly Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  39
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  GMCSF leader peptide

<400>  39
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccg                                                                  66


<210>  40
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  GMCSF leader peptide

<400>  40

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210>  41
<211>  85
<212>  DNA
<213>  Artificial

<220>
<223>  TNFRSF19 leader peptide

<400>  41
ggctctgaaa gtgctgttgg aacaagaaaa gaccttcttc accttgctcg tgttgctggg       60

gtacctgtcc tgcaaagtca cctgt                                             85


<210>  42
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  TNFRSF19 leader peptide

<400>  42

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys 
            20                  25                  


<210>  43
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  CD8 alpha leader peptide

<400>  43
atggcgctgc cggtgaccgc gctgctgctg ccgctggcgc tgctgctgca tgcggcgcgc       60

ccg                                                                     63


<210>  44
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  CD8 alpha leader peptide

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  45
<211>  123
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 co-stimulatory domain

<400>  45
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  46
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  CD28 co-stimulatory domain

<400>  46

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  47
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD3 zeta activation domain

<400>  47
agagtgaagt tcagccgctc agccgatgca ccggcctacc agcagggaca gaaccagctc       60

tacaacgagc tcaacctggg tcggcgggaa gaatatgacg tgctggacaa acggcgcggc      120

agagatccgg agatgggggg aaagccgagg aggaagaacc ctcaagaggg cctgtacaac      180

gaactgcaga aggacaagat ggcggaagcc tactccgaga tcggcatgaa gggagaacgc      240

cggagaggga agggtcatga cggactgtac cagggcctgt caactgccac taaggacact      300

tacgatgcgc tccatatgca agctttgccc ccgcgg                                336


<210>  48
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3 zeta activation domain

<400>  48

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  49
<211>  201
<212>  DNA
<213>  Artificial

<220>
<223>  TNFRSF19 hinge and transmembrane domain

<400>  49
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctggc cgccgtgatt tgttccgcct tggccaccgt gcttctggcc      180

ctgctgatcc tctgtgtgat c                                                201


<210>  50
<211>  67
<212>  PRT
<213>  Artificial

<220>
<223>  TNFRSF19 hinge and transmembrane domain

<400>  50

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile 
65          


<210>  51
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  TNFRSF19 transmembrane domain

<400>  51
gccgccgtga tttgttccgc cttggccacc gtgcttctgg ccctgctgat cctctgtgtg       60

atc                                                                     63


<210>  52
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  TNFRSF19 transmembrane domain

<400>  52

Ala Ala Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ile Leu Cys Val Ile 
            20      


<210>  53
<211>  138
<212>  DNA
<213>  Artificial

<220>
<223>  TNFRSF19 hinge domain

<400>  53
gcggccgcgg tcggattcca agacatggaa tgcgtgccct gcggcgaccc gccacctcct       60

tacgagccgc actgcgcatc gaaggtcaac ctcgtgaaga tcgcgagcac cgcgtcctca      120

ccccgggata ctgctctg                                                    138


<210>  54
<211>  46
<212>  PRT
<213>  Artificial

<220>
<223>  TNFRSF19 hinge domain

<400>  54

Ala Ala Ala Val Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp 
1               5                   10                  15      


Pro Pro Pro Pro Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val 
            20                  25                  30          


Lys Ile Ala Ser Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
        35                  40                  45      


<210>  55
<211>  80
<212>  DNA
<213>  Artificial

<220>
<223>  truncated TNFRSF19 hinge domain

<400>  55
tacgagcctc actgcgccag caaagtcaac ttggtgaaga tcgcgagcac tgcctcgtcc       60

cctcgggaca ctgctctggc                                                   80


<210>  56
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  TNFRSF19 hinge domain

<400>  56

Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
1               5                   10                  15      


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu 
            20                  25      


<210>  57
<211>  222
<212>  DNA
<213>  Artificial

<220>
<223>  CD8a hinge domain fused to TNFRSF19 transmembrane

<400>  57
gcggccgcgc ccgcccctcg gcccccgact cctgccccga cgatcgcttc ccaacctctc       60

tcgctgcgcc cggaagcatg ccggcccgcc gccggtggcg ctgtccacac tcgcggactg      120

gactttgata ccgcactggc ggccgtgatc tgtagcgccc tggccaccgt gctgctggcg      180

ctgctcatcc tttgcgtgat ctactgcaag cggcagccta gg                         222


<210>  58
<211>  74
<212>  PRT
<213>  Artificial

<220>
<223>  CD8a hinge domain fused to TNFRSF19 transmembrane

<400>  58

Ala Ala Ala Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Asp Thr Ala Leu Ala Ala 
        35                  40                  45              


Val Ile Cys Ser Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu 
    50                  55                  60                  


Cys Val Ile Tyr Cys Lys Arg Gln Pro Arg 
65                  70                  


<210>  59
<211>  123
<212>  DNA
<213>  Artificial

<220>
<223>  CD28 co-stimulatory domain

<400>  59
cggtcgaaga ggtccagact cttgcactcc gactacatga acatgactcc tagaaggccc       60

ggacccacta gaaagcacta ccagccgtac gcccctcctc gggatttcgc cgcataccgg      120

tcc                                                                    123


<210>  60
<211>  41
<212>  PRT
<213>  Artificial

<220>
<223>  CD28 co-stimulatory domain

<400>  60

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  61
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  CD3 zeta version 2

<400>  61
cgcgtgaaat ttagccgcag cgcggatgcg ccggcgtatc agcagggcca gaaccagctg       60

tataacgaac tgaacctggg ccgccgcgaa gaatatgatg tgctggataa acgccgcggc      120

cgcgatccgg aaatgggcgg caaaccgcgc cgcaaaaacc cgcaggaagg cctgtataac      180

gaactgcaga aagataaaat ggcggaagcg tatagcgaaa ttggcatgaa aggcgaacgc      240

cgccgcggca aaggccatga tggcctgtat cagggcctga gcaccgcgac caaagatacc      300

tatgatgcgc tgcatatgca ggcgctgccg ccgcgc                                336


<210>  62
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  CD3 zeta version 2

<400>  62

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  63
<211>  93
<212>  DNA
<213>  Artificial

<220>
<223>  Furin P2A Furin

<400>  63
cgcgcgaaac gcagcggcag cggcgcgacc aactttagcc tgctgaaaca ggcgggcgat       60

gtggaagaaa acccgggccc gcgagcaaag agg                                    93


<210>  64
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Furin P2A Furin

<400>  64

Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg 
            20                  25                  30      


<210>  65
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Furin T2A

<400>  65
agagctaaac gctctgggtc tggtgaagga cgaggtagcc ttcttacgtg cggagacgtg       60

gaggaaaacc caggaccc                                                     78


<210>  66
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Furin T2A

<400>  66

Arg Ala Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      


<210>  67
<211>  1005
<212>  DNA
<213>  Artificial

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  67
aggaaggttt gcaatggaat cggtataggg gagtttaagg attcacttag cataaacgct       60

actaatatta aacacttcaa aaactgtacg agtataagtg gagatcttca cattttgccg      120

gttgcattcc gaggcgattc attcacccac acgccaccgc ttgacccaca agaattggat      180

attcttaaaa ccgttaaaga aataacgggg tttttgctca ttcaagcgtg gccagaaaat      240

cgcactgacc tccatgcttt cgagaacctg gagattataa gaggacgaac taagcagcat      300

ggtcaattct cccttgctgt ggtcagcctg aacatcacca gtcttggttt gcggtccctc      360

aaggaaattt cagatggaga tgtcatcata agcggcaaca agaatttgtg ctatgcaaat      420

accataaact ggaaaaaact gtttggcact tccggccaga aaaccaagat tatttcaaat      480

cggggtgaga acagctgcaa agccaccggc caggtttgtc atgccttgtg ctctccggaa      540

ggctgttggg ggccagaacc cagggactgc gtcagttgca gaaacgtctc aagaggccgc      600

gaatgcgttg acaagtgtaa cctccttgag ggtgagccac gagagtttgt tgagaacagc      660

gagtgtatac aatgtcaccc tgaatgtttg ccccaggcta tgaatataac ctgcacaggc      720

cgcgggcctg ataactgcat ccagtgtgct cattacatag atggacctca ctgtgtgaaa      780

acctgcccgg ccggagttat gggagaaaac aacactctgg tgtggaaata cgctgatgca      840

ggccacgtgt gccacctttg tcacccgaat tgtacatatg ggtgtaccgg tcctggactt      900

gaaggttgcc ctaccaatgg ccctaaaata cccagtatcg caactggcat ggtaggcgct      960

cttctcttgc tcttggtagt tgctctcggc ataggtcttt ttatg                     1005


<210>  68
<211>  335
<212>  PRT
<213>  Artificial

<220>
<223>  truncated EGFR (tEGFR) tag

<400>  68

Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu 
1               5                   10                  15      


Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile 
            20                  25                  30          


Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe 
        35                  40                  45              


Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr 
    50                  55                  60                  


Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn 
65                  70                  75                  80  


Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg 
                85                  90                  95      


Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile 
            100                 105                 110         


Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val 
        115                 120                 125             


Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp 
    130                 135                 140                 


Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn 
145                 150                 155                 160 


Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu 
                165                 170                 175     


Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser 
            180                 185                 190         


Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu 
        195                 200                 205             


Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln 
    210                 215                 220                 


Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly 
225                 230                 235                 240 


Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro 
                245                 250                 255     


His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr 
            260                 265                 270         


Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His 
        275                 280                 285             


Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro 
    290                 295                 300                 


Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala 
305                 310                 315                 320 


Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met 
                325                 330                 335 


<210>  69
<211>  744
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-40

<400>  69
caggcggccg aggtgcagct ggtgcagtct gggggaggcg tggtccagcc tggggggtcc       60

ctgagactct cctgtgcagc gtctggattc accttcagta gctatggcat gcactgggtc      120

cgccaggctc caggcaaggg gctggagtgg gtggcattta tacggtatga tggaagtaat      180

aaatactacg cagactccgt gaagggccga ttcaccatct ccagagacaa ttccaagaac      240

acgctgtatc tgcaaatgaa cagcctgaga gctgaggaca cggctgtgta ttactgtgcg      300

aaagaacccc ccgagtatta ctatgatagt agtggttatt cgtggggcca gggaaccctg      360

gtcaccgtct cctcaggagg tggcggatct ggtggaggcg gtagcggtgg tggcggatcc      420

gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc aggcgagtca ggacattgac acctatttaa actggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      600

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      660

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      720

gggacacgac tggagattaa acga                                             744


<210>  70
<211>  248
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-40

<400>  70

Gln Ala Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
65                  70                  75                  80  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Glu Pro Pro Glu Tyr Tyr Tyr Asp Ser Ser Gly 
            100                 105                 110         


Tyr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Gln Ala Ser Gln Asp Ile Asp Thr Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Arg Leu Glu Ile Lys Arg 
                245             


<210>  71
<211>  729
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-49

<400>  71
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgt gagcgatgac      300

tacggtggta actccgggac tagctactgg ggccagggaa ccctggtcac cgtctcctca      360

ggaggtggcg gatctggtgg aggcggtagc ggtggtggcg gatccgacat ccagatgacc      420

cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccaggcg      480

agtcaggaca ttagcaacta tttaaattgg tatcagcaga agccagggaa agcccctaag      540

ctcctgatct acgatgcatc caatttggaa acaggggtcc catcaaggtt cagtggcagt      600

ggatctggga cagatttcac tctcaccatc agcagtctgc aacctgaaga ttttgcaact      660

tactactgtc aacagagtta cagtaccccc gtgacgttcg gcggagggac caagctgacc      720

gtcctaggt                                                              729


<210>  72
<211>  243
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-49

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Ser Asp Asp Tyr Gly Gly Asn Ser Gly Thr Ser Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 
145                 150                 155                 160 


Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Ser Tyr Ser Thr Pro Val Thr Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  73
<211>  711
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-50

<400>  73
gaggtgcagc tggtgcagtc tgggggaggt gtggtacggc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt acttatgaaa tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg gcttgcatac attggaggta gtggtagtcc catatactac      180

gcagactctg tgaggggccg attcaccatc tccagagaca acaccaagaa ttcactattt      240

ctccaaatga gcagcctgag agccgaggac accgctgttt actattgtgt ggaagggtgg      300

tttgacaagt ggggcctggg aaccctggtc accgtctcct caggaggtgg cggatctggt      360

ggaggcggta gcggtggtgg cggatccgac atccagttga cccagtctcc atccaccctg      420

tctgcatctg taggagacag agtcaccatc acttgccggg caagtcagag cattagcagc      480

tatttaaatt ggtatcagca gaaaccaggg aaagccccta agctcctgat ctacgatgca      540

tccaatttgg agacaggggt cccatcaagg ttcagtggaa gtggatctgg gacagatttc      600

actctcacca tcagcagtct gcaacctgaa gattttgcaa cttactactg tcaacagagt      660

tacagtaccc cgtacacttt tggccagggg accaagctgg aaatcaaacg t               711


<210>  74
<211>  237
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-50

<400>  74

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ala Tyr Ile Gly Gly Ser Gly Ser Pro Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Glu Gly Trp Phe Asp Lys Trp Gly Leu Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val 
    130                 135                 140                 


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser 
145                 150                 155                 160 


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
                165                 170                 175     


Ile Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser 
            180                 185                 190         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
        195                 200                 205             


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
    210                 215                 220                 


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
225                 230                 235         


<210>  75
<211>  732
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-4-12

<400>  75
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt agttacgtta tacattgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagct atatcgcatg atggaagcaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

cttcaaatga gcagtctgag cgctgaggac acggctatgt attactgtgt gaaaactagt      300

agtgattatt actacgccta ctggggccag ggaaccctgg tcaccgtctc ctcaggaggt      360

ggcgggtctg gtggaggcgg tagcggtggt ggcggatccc agactgtggt gactcaggag      420

ccatcgttct cagtgtcccc tggagggaca gtcacactca cttgtggctt gagctctggc      480

tcagtctcta ctggcaactc ccccacctgg taccagcaga ccccaggcca ggctccacgc      540

acgctcatct acagcacaaa cactcgctct tctggggtcc ctgatcgctt ctctggctcc      600

atccttggga acaaagctgc cctcaccatc acgggggccc aggcagatga tgaatctgat      660

tattactgtg tgctgtatat gggtagtggc tattgggtgt tcggcggagg gaccaaggtc      720

accgtcctag gt                                                          732


<210>  76
<211>  244
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder MTB-4-12

<400>  76

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Val Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser His Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Ser Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Lys Thr Ser Ser Asp Tyr Tyr Tyr Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser 
    130                 135                 140                 


Val Ser Pro Gly Gly Thr Val Thr Leu Thr Cys Gly Leu Ser Ser Gly 
145                 150                 155                 160 


Ser Val Ser Thr Gly Asn Ser Pro Thr Trp Tyr Gln Gln Thr Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Thr Leu Ile Tyr Ser Thr Asn Thr Arg Ser Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu 
        195                 200                 205             


Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Val 
    210                 215                 220                 


Leu Tyr Met Gly Ser Gly Tyr Trp Val Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Thr Val Leu Gly 
                


<210>  77
<211>  723
<212>  DNA
<213>  Artificial

<220>
<223>  BCMA ScFv binder  MTB-4-45

<400>  77
gaggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg catctggata cacctccacc agctactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac      180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac      240

atggagctga gcagcttgag atctgaggac acggccgtgt attactgtgc gagagatttg      300

ggtgatggcg cttttgatat ctggggccaa gggacaatgg tcaccgtctc ttcaggaggt      360

ggcgggtctg gtggaggcgg tagcggtggt ggcggatccg acatccagat gacccagtct      420

ctatcctccc tgtctgcatc tgtaggagac agagtcacca tcgcttgccg ggcaagtcag      480

accattagta ggtatttaaa ttggtatcag cagaaaccag ggaaagcccc taagctcctg      540

atctatgctg catccagttt gcaaagtggg gtctcatcaa ggttcagtgg cagtggatct      600

gggacagagt tcactctcac catcagcagt ctgcagcctg aagattttgc aacttatttc      660

tgtcaacaga cttacagtcc cccgatcacc ttcggccaag ggacacgact ggagattaaa      720

cga                                                                    723


<210>  78
<211>  241
<212>  PRT
<213>  Artificial

<220>
<223>  BCMA ScFv binder  MTB-4-45

<400>  78

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Ser Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Asp Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Leu Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Ala Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser 
            180                 185                 190         


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr 
    210                 215                 220                 


Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
225                 230                 235                 240 


Arg 
    


<210>  79
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  79
gagagcaaat acgggccgcc atgtcccccg tgtccg                                 36


<210>  80
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  80

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro 
1               5                   10          


<210>  81
<211>  327
<212>  DNA
<213>  Homo sapiens

<400>  81
gcaccaccag ttgctggccc tagtgtcttc ttgttccctc ccaagcccaa agacaccttg       60

atgatttcca gaactcctga ggttacctgc gttgtcgtag atgtttctca ggaggaccca      120

gaggtccaat ttaactggta cgttgatggg gtggaagttc acaatgcgaa gacaaagccg      180

cgggaagaac aatttcagtc cacttaccgg gttgtcagcg ttctgacggt attgcatcaa      240

gactggctta atggaaagga atataagtgt aaggtgtcca acaaaggttt gccgagcagt      300

attgagaaga ccatatcaaa ggcgaag                                          327


<210>  82
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 


<210>  83
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  83
gggcagccgc gcgagccaca agtttacact ttgccgccat ctcaagagga aatgactaaa       60

aaccaggtat ccttgacatg cctcgtaaaa ggattttatc catctgatat tgctgtggaa      120

tgggagtcta acgggcagcc ggaaaataat tacaaaacta caccacctgt gctcgattca      180

gatggaagtt tcttccttta cagtagactt acggtggaca aatctaggtg gcaggaaggg      240

aatgtgttta gttgtagtgt aatgcacgag gcacttcata accactatac acagaagtca      300

ctgagtttga gtcttggcaa a                                                321


<210>  84
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  84

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  85
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  85
gagagcaaat acgggccgcc atgtcccccg tgtccggcac caccagttgc tggccctagt       60

gtcttcttgt tccctcccaa gcccaaagac accttgatga tttccagaac tcctgaggtt      120

acctgcgttg tcgtagatgt ttctcaggag gacccagagg tccaatttaa ctggtacgtt      180

gatggggtgg aagttcacaa tgcgaagaca aagccgcggg aagaacaatt tcagtccact      240

taccgggttg tcagcgttct gacggtattg catcaagact ggcttaatgg aaaggaatat      300

aagtgtaagg tgtccaacaa aggtttgccg agcagtattg agaagaccat atcaaaggcg      360

aaggggcagc cgcgcgagcc acaagtttac actttgccgc catctcaaga ggaaatgact      420

aaaaaccagg tatccttgac atgcctcgta aaaggatttt atccatctga tattgctgtg      480

gaatgggagt ctaacgggca gccggaaaat aattacaaaa ctacaccacc tgtgctcgat      540

tcagatggaa gtttcttcct ttacagtaga cttacggtgg acaaatctag gtggcaggaa      600

gggaatgtgt ttagttgtag tgtaatgcac gaggcacttc ataaccacta tacacagaag      660

tcactgagtt tgagtcttgg caaa                                             684


<210>  86
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  86

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Gln Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Gly Lys 
225             


<210>  87
<211>  1497
<212>  DNA
<213>  Artificial

<220>
<223>  D0084 (Ef1a-BCMA sequence 5 CD8 BBz)

<400>  87
atgctgctgc tggtgaccag cctgcttctg tgtgaactgc cgcatccggc gtttctgctg       60

attccggagg tccagctggt gcagtctgga ggaggcgtgg tccagcctgg tgggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcatttatac ggtatgatgg aagtaataaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaga      360

gattgggccg gggattgtac taatggccaa tgcggcgtct actggggaca gggaaccctg      420

gtcaccgtct cctcaggagg tggcggatct ggtggaggcg gtagcggtgg tggcggatcc      480

gaaattgtgt tgacgcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc      540

atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg      600

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc      660

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc      720

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactccg      780

tacacttttg gccaggggac caagctggag atcaaacgtg cggccgcaac gaccactcct      840

gcaccccgcc ctccgactcc ggccccaacc attgccagcc agcccctgtc cctgcggccg      900

gaagcctgca gaccggctgc cggcggagcc gtccataccc ggggactgga tttcgcctgc      960

gatatctata tctgggcacc actcgccgga acctgtggag tgctgctgct gtcccttgtg     1020

atcaccctgt actgcaagcg cggacggaag aaactcttgt acatcttcaa gcagccgttc     1080

atgcgccctg tgcaaaccac ccaagaagag gacgggtgct cctgccggtt cccggaagag     1140

gaagagggcg gctgcgaact gcgcgtgaag ttttcccggt ccgccgacgc tccggcgtac     1200

cagcaggggc aaaaccagct gtacaacgaa cttaacctcg gtcgccggga agaatatgac     1260

gtgctggaca agcggcgggg aagagatccc gagatgggtg gaaagccgcg gcggaagaac     1320

cctcaggagg gcttgtacaa cgagctgcaa aaggacaaaa tggccgaagc ctactccgag     1380

attggcatga agggagagcg cagacgcggg aagggacacg atggactgta ccagggactg     1440

tcaaccgcga ctaaggacac ttacgacgcc ctgcacatgc aggccctgcc cccgcgc        1497


<210>  88
<211>  499
<212>  PRT
<213>  Artificial

<220>
<223>  D0084 (Ef1a-BCMA sequence 5 CD8 BBz)

<400>  88

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Trp Ala Gly Asp Cys Thr Asn 
        115                 120                 125             


Gly Gln Cys Gly Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
                165                 170                 175     


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            180                 185                 190         


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        195                 200                 205             


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    210                 215                 220                 


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
225                 230                 235                 240 


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                245                 250                 255     


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270         


Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  89
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  D0085 (Ef1a-BCMA sequence 16 CD8 BBz)

<400>  89
atgctgctgc tggtgaccag cctgcttctg tgcgaactgc cgcatccggc gtttctgttg       60

attccggagg tccagctggt gcagtctggg ggaggcgtgg tccagcctgg ggggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcatttatac ggtatgatgg aagtaataaa      240

tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaga      360

gaccttaatg actacggtga cccaccccct tactggggcc agggaaccct ggtcaccgtc      420

tcctcaggag gtggcggatc tggtggaggc ggtagcggtg gtggcggatc cgacatccag      480

atgacccagt ctccatcctc cctgtctgca tctgtaggag acagagtcac catcacttgc      540

cgggcaagtc agagcattag cagctattta aattggtatc agcagaaacc agggaaagcc      600

cctaagctcc tgatctacga tgcatccaat ttggaaacag gggtctcatc aaggttcagt      660

ggcagtggat ctgggacaga gttcactctc accatcagca gtctgcagcc tgaagatttt      720

gcaacttatt tctgtcaaca gacttacagt cccccgatca ccttcggcca agggacacga      780

ctggagatta aacgagcggc cgcaacgacc actcctgcac cccgccctcc gactccggcc      840

ccaaccattg ccagccagcc cctgtccctg cggccggaag cctgcagacc ggctgccggc      900

ggagccgtcc atacccgggg actggatttc gcctgcgata tctatatctg ggcaccactc      960

gccggaacct gtggagtgct gctgctgtcc cttgtgatca ccctgtactg caagcgcgga     1020

cggaagaaac tcttgtacat cttcaagcag ccgttcatgc gccctgtgca aaccacccaa     1080

gaagaggacg ggtgctcctg ccggttcccg gaagaggaag agggcggctg cgaactgcgc     1140

gtgaagtttt cccggtccgc cgacgctccg gcgtaccagc aggggcaaaa ccagctgtac     1200

aacgaactta acctcggtcg ccgggaagaa tatgacgtgc tggacaagcg gcggggaaga     1260

gatcccgaga tgggtggaaa gccgcggcgg aagaaccctc aggagggctt gtacaacgag     1320

ctgcaaaagg acaaaatggc cgaagcctac tccgagattg gcatgaaggg agagcgcaga     1380

cgcgggaagg gacacgatgg actgtaccag ggactgtcaa ccgcgactaa ggacacttac     1440

gacgccctgc acatgcaggc cctgcccccg cgc                                  1473


<210>  90
<211>  491
<212>  PRT
<213>  Artificial

<220>
<223>  D0085 (Ef1a-BCMA sequence 16 CD8 BBz)

<400>  90

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Asn Asp Tyr Gly Asp Pro 
        115                 120                 125             


Pro Pro Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln 
145                 150                 155                 160 


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
                165                 170                 175     


Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp 
            180                 185                 190         


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala 
        195                 200                 205             


Ser Asn Leu Glu Thr Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser 
    210                 215                 220                 


Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
225                 230                 235                 240 


Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly 
                245                 250                 255     


Gln Gly Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  91
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  D0086 (Ef1a-BCMA sequence 37 CD8 BBz) (Ef1a-BCMA sequence 37 CD8 
       BBz)

<400>  91
atgctgctgc tggtgaccag cctgcttctg tgcgaactgc cgcatccggc gtttctgttg       60

attccggagg tgcagctggt ggagtctggg ggaggcttgg tcaagcctgg agggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcatttatac ggtatgatgg aagtaataaa      240

tactatgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaaa      360

gattgggaat atagtggata cgatgcacac ccgggatggg gtcagggaac cctggtcacc      420

gtctcttcag gaggtggtgg gtctggtgga ggcggtagcg gtggtggcgg atccgacatc      480

cagttgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcact      540

tgccgggcaa gtcagggcat tagcagtgct ttagcctggt atcagcagaa accagggaaa      600

gctcctaagc tcctgatcta tgatgcctcc agtttggaaa gtggggtccc atcaaggttc      660

agtggcagtg gatctgggac agagttcact ctcaccatca gcagtctgca gcctgaagat      720

tttgcaactt atttctgtca acagacttac agtcccccga tcaccttcgg ccaagggaca      780

cgactggaga ttaaacgagc ggccgcaacg accactcctg caccccgccc tccgactccg      840

gccccaacca ttgccagcca gcccctgtcc ctgcggccgg aagcctgcag accggctgcc      900

ggcggagccg tccatacccg gggactggat ttcgcctgcg atatctatat ctgggcacca      960

ctcgccggaa cctgtggagt gctgctgctg tcccttgtga tcaccctgta ctgcaagcgc     1020

ggacggaaga aactcttgta catcttcaag cagccgttca tgcgccctgt gcaaaccacc     1080

caagaagagg acgggtgctc ctgccggttc ccggaagagg aagagggcgg ctgcgaactg     1140

cgcgtgaagt tttcccggtc cgccgacgct ccggcgtacc agcaggggca aaaccagctg     1200

tacaacgaac ttaacctcgg tcgccgggaa gaatatgacg tgctggacaa gcggcgggga     1260

agagatcccg agatgggtgg aaagccgcgg cggaagaacc ctcaggaggg cttgtacaac     1320

gagctgcaaa aggacaaaat ggccgaagcc tactccgaga ttggcatgaa gggagagcgc     1380

agacgcggga agggacacga tggactgtac cagggactgt caaccgcgac taaggacact     1440

tacgacgccc tgcacatgca ggccctgccc ccgcgc                               1476


<210>  92
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  D0086 (Ef1a-BCMA sequence 37 CD8 BBz) (Ef1a-BCMA sequence 37 CD8 
       BBz)

<400>  92

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Lys Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Asp Trp Glu Tyr Ser Gly Tyr Asp 
        115                 120                 125             


Ala His Pro Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
        195                 200                 205             


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  93
<211>  1479
<212>  DNA
<213>  Artificial

<220>
<223>  D0087_LTG2092 (Ef1a-BCMA sequence 40 CD8 BBz)

<400>  93
atgctgctgc tggtgaccag cctgcttctg tgcgaactgc cgcatccggc gtttcttctg       60

attccggagg tgcagctggt gcagtctggg ggaggcgtgg tccagcctgg ggggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcatttatac ggtatgatgg aagtaataaa      240

tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaaa      360

gaaccccccg agtattacta tgatagtagt ggttattcgt ggggccaggg aaccctggtc      420

accgtctcct caggaggtgg cgggtctggt ggaggcggta gcggtggtgg cggatccgac      480

atccagttga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc      540

acttgccagg cgagtcagga cattgacacc tatttaaact ggtatcagca gaaaccaggg      600

aaagccccta agctcctgat ctatgctgca tccagtttgc aaagtggggt ctcatcaagg      660

ttcagtggca gtggatctgg gacagagttc actctcacca tcagcagtct gcagcctgaa      720

gattttgcaa cttatttctg tcaacagact tacagtcccc cgatcacctt cggccaaggg      780

acacgactgg agattaaacg agcggccgca acgaccactc ctgcaccccg ccctccgact      840

ccggccccaa ccattgccag ccagcccctg tccctgcggc cggaagcctg cagaccggct      900

gccggcggag ccgtccatac ccggggactg gatttcgcct gcgatatcta tatctgggca      960

ccactcgccg gaacctgtgg agtgctgctg ctgtcccttg tgatcaccct gtactgcaag     1020

cgcggacgga agaaactctt gtacatcttc aagcagccgt tcatgcgccc tgtgcaaacc     1080

acccaagaag aggacgggtg ctcctgccgg ttcccggaag aggaagaggg cggctgcgaa     1140

ctgcgcgtga agttttcccg gtccgccgac gctccggcgt accagcaggg gcaaaaccag     1200

ctgtacaacg aacttaacct cggtcgccgg gaagaatatg acgtgctgga caagcggcgg     1260

ggaagagatc ccgagatggg tggaaagccg cggcggaaga accctcagga gggcttgtac     1320

aacgagctgc aaaaggacaa aatggccgaa gcctactccg agattggcat gaagggagag     1380

cgcagacgcg ggaagggaca cgatggactg taccagggac tgtcaaccgc gactaaggac     1440

acttacgacg ccctgcacat gcaggccctg cccccgcgc                            1479


<210>  94
<211>  493
<212>  PRT
<213>  Artificial

<220>
<223>  D0087_LTG2092 (Ef1a-BCMA sequence 40 CD8 BBz)

<400>  94

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Glu Pro Pro Glu Tyr Tyr Tyr Asp 
        115                 120                 125             


Ser Ser Gly Tyr Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
145                 150                 155                 160 


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asp Thr Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr 
                245                 250                 255     


Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr 
            260                 265                 270         


Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln 
        275                 280                 285             


Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala 
    290                 295                 300                 


Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala 
305                 310                 315                 320 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                325                 330                 335     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            340                 345                 350         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        355                 360                 365             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    370                 375                 380                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                405                 410                 415     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210>  95
<211>  1476
<212>  DNA
<213>  Artificial

<220>
<223>  D0099_LTG2944 (Ef1a-BCMA sequence 4-12 CD8 BBz)

<400>  95
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccgcagg tgcagctggt gcagtctggg ggaggcgtgg tccagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc ttcagtagtt acgttataca ttgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcagctatat cgcatgatgg aagcaataaa      240

tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatcttc aaatgagcag tctgagcgct gaggacacgg ctatgtatta ctgtgtgaaa      360

actagtagtg attattacta cgcctactgg ggccagggaa ccctggtcac cgtctcctca      420

ggaggtggcg ggtctggtgg aggcggtagc ggtggtggcg gatcccagac tgtggtgact      480

caggagccat cgttctcagt gtcccctgga gggacagtca cactcacttg tggcttgagc      540

tctggctcag tctctactgg caactccccc acctggtacc agcagacccc aggccaggct      600

ccacgcacgc tcatctacag cacaaacact cgctcttctg gggtccctga tcgcttctct      660

ggctccatcc ttgggaacaa agctgccctc accatcacgg gggcccaggc agatgatgaa      720

tctgattatt actgtgtgct gtatatgggt agtggctatt gggtgttcgg cggagggacc      780

aaggtcaccg tcctaggtgc ggccgcaacg accactcctg caccccgccc tccgactccg      840

gccccaacca ttgccagcca gcccctgtcc ctgcggccgg aagcctgcag accggctgcc      900

ggcggagccg tccatacccg gggactggat ttcgcctgcg atatctatat ctgggcacca      960

ctcgccggaa cctgtggagt gctgctgctg tcccttgtga tcaccctgta ctgcaagcgc     1020

ggacggaaga aactcttgta catcttcaag cagccgttca tgcgccctgt gcaaaccacc     1080

caagaagagg acgggtgctc ctgccggttc ccggaagagg aagagggcgg ctgcgaactg     1140

cgcgtgaagt tttcccggtc cgccgacgct ccggcgtacc agcaggggca aaaccagctg     1200

tacaacgaac ttaacctcgg tcgccgggaa gaatatgacg tgctggacaa gcggcgggga     1260

agagatcccg agatgggtgg aaagccgcgg cggaagaacc ctcaggaggg cttgtacaac     1320

gagctgcaaa aggacaaaat ggccgaagcc tactccgaga ttggcatgaa gggagagcgc     1380

agacgcggga agggacacga tggactgtac cagggactgt caaccgcgac taaggacact     1440

tacgacgccc tgcacatgca ggccctgccc ccgcgc                               1476


<210>  96
<211>  492
<212>  PRT
<213>  Artificial

<220>
<223>  D0099_LTG2944 (Ef1a-BCMA sequence 4-12 CD8 BBz)

<400>  96

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Val Ile His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ala Ile Ser His Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Ser Ala Glu Asp 
            100                 105                 110         


Thr Ala Met Tyr Tyr Cys Val Lys Thr Ser Ser Asp Tyr Tyr Tyr Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Thr Val Val Thr 
145                 150                 155                 160 


Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly Thr Val Thr Leu Thr 
                165                 170                 175     


Cys Gly Leu Ser Ser Gly Ser Val Ser Thr Gly Asn Ser Pro Thr Trp 
            180                 185                 190         


Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr Leu Ile Tyr Ser Thr 
        195                 200                 205             


Asn Thr Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Leu 
    210                 215                 220                 


Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln Ala Asp Asp Glu 
225                 230                 235                 240 


Ser Asp Tyr Tyr Cys Val Leu Tyr Met Gly Ser Gly Tyr Trp Val Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Thr Val Leu Gly Ala Ala Ala Thr Thr Thr 
            260                 265                 270         


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
        275                 280                 285             


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
    290                 295                 300                 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
305                 310                 315                 320 


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
                325                 330                 335     


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
            420                 425                 430         


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
        435                 440                 445             


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
    450                 455                 460                 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
465                 470                 475                 480 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490         


<210>  97
<211>  1467
<212>  DNA
<213>  Artificial

<220>
<223>  D0100_LTG2945 (Ef1a-BCMA sequence 4-45 CD8 BBz)

<400>  97
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcatc tggatacacc tccaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaataatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cttgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

gatttgggtg atggcgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

ggaggtggcg ggtctggtgg aggcggtagc ggtggtggcg gatccgacat ccagatgacc      480

cagtctctat cctccctgtc tgcatctgta ggagacagag tcaccatcgc ttgccgggca      540

agtcagacca ttagtaggta tttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtct catcaaggtt cagtggcagt      660

ggatctggga cagagttcac tctcaccatc agcagtctgc agcctgaaga ttttgcaact      720

tatttctgtc aacagactta cagtcccccg atcaccttcg gccaagggac acgactggag      780

attaaacgag cggccgcaac gaccactcct gcaccccgcc ctccgactcc ggccccaacc      840

attgccagcc agcccctgtc cctgcggccg gaagcctgca gaccggctgc cggcggagcc      900

gtccataccc ggggactgga tttcgcctgc gatatctata tctgggcacc actcgccgga      960

acctgtggag tgctgctgct gtcccttgtg atcaccctgt actgcaagcg cggacggaag     1020

aaactcttgt acatcttcaa gcagccgttc atgcgccctg tgcaaaccac ccaagaagag     1080

gacgggtgct cctgccggtt cccggaagag gaagagggcg gctgcgaact gcgcgtgaag     1140

ttttcccggt ccgccgacgc tccggcgtac cagcaggggc aaaaccagct gtacaacgaa     1200

cttaacctcg gtcgccggga agaatatgac gtgctggaca agcggcgggg aagagatccc     1260

gagatgggtg gaaagccgcg gcggaagaac cctcaggagg gcttgtacaa cgagctgcaa     1320

aaggacaaaa tggccgaagc ctactccgag attggcatga agggagagcg cagacgcggg     1380

aagggacacg atggactgta ccagggactg tcaaccgcga ctaaggacac ttacgacgcc     1440

ctgcacatgc aggccctgcc cccgcgc                                         1467


<210>  98
<211>  489
<212>  PRT
<213>  Artificial

<220>
<223>  D0100_LTG2945 (Ef1a-BCMA sequence 4-45 CD8 BBz)

<400>  98

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Ser Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Gly Asp Gly Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Leu Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210>  99
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  D0153 (BCMA 4-1c CD8 BBz)

<400>  99
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tgcagctggt ggagaccggg ggaggcgtgg tccagcctgg ggggtccctg      120

agactctcct gtgcagcgtc tggattcacc ttcagtagct atggcatgca ctgggtccgc      180

caggctccag gcaaggggct ggagtgggtg gcatttatac ggtatgatgg aagtaataaa      240

tactacgcag actccgtgaa gggccgattc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagct gaggacacgg ctgtgtatta ctgtgcgaaa      360

gattgggata cgtattacta tgatagtagt ggttatgatc gggcctgggg ccagggaacc      420

ctggtcaccg tctcctcagg aggtggcggg tctggtggag gcggtagcgg tggtggcgga      480

tccgacatcc agatgaccca gtctccctcc tccctgtctg catctgtagg agacagagtc      540

accatcactt gccaggcgag tcaggacatt aacaactatt taaattggta tcagcagaaa      600

ccagggaaag cccctaagct cctgatctat gctgcatcca gtttgcaaag tggggtctca      660

tcaaggttca gtggcagtgg atctgggaca gagttcactc tcaccatcag cagtctgcag      720

cctgaagatt ttgcaactta tttctgtcaa cagacttaca gtcccccgat caccttcggc      780

caagggacac gactggagat taaacgagcg gccgcaacga ccactcctgc accccgccct      840

ccgactccgg ccccaaccat tgccagccag cccctgtccc tgcggccgga agcctgcaga      900

ccggctgccg gcggagccgt ccatacccgg ggactggatt tcgcctgcga tatctatatc      960

tgggcaccac tcgccggaac ctgtggagtg ctgctgctgt cccttgtgat caccctgtac     1020

tgcaagcgcg gacggaagaa actcttgtac atcttcaagc agccgttcat gcgccctgtg     1080

caaaccaccc aagaagagga cgggtgctcc tgccggttcc cggaagagga agagggcggc     1140

tgcgaactgc gcgtgaagtt ttcccggtcc gccgacgctc cggcgtacca gcaggggcaa     1200

aaccagctgt acaacgaact taacctcggt cgccgggaag aatatgacgt gctggacaag     1260

cggcggggaa gagatcccga gatgggtgga aagccgcggc ggaagaaccc tcaggagggc     1320

ttgtacaacg agctgcaaaa ggacaaaatg gccgaagcct actccgagat tggcatgaag     1380

ggagagcgca gacgcgggaa gggacacgat ggactgtacc agggactgtc aaccgcgact     1440

aaggacactt acgacgccct gcacatgcag gccctgcccc cgcgc                     1485


<210>  100
<211>  495
<212>  PRT
<213>  Artificial

<220>
<223>  D0153 (BCMA 4-1c CD8 BBz)

<400>  100

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Glu Thr Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Asp Trp Asp Thr Tyr Tyr Tyr Asp 
        115                 120                 125             


Ser Ser Gly Tyr Asp Arg Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
                165                 170                 175     


Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn 
            180                 185                 190         


Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        195                 200                 205             


Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser 
    210                 215                 220                 


Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln 
225                 230                 235                 240 


Pro Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro 
                245                 250                 255     


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala 
            260                 265                 270         


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
        275                 280                 285             


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
    290                 295                 300                 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
305                 310                 315                 320 


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
                325                 330                 335     


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
            340                 345                 350         


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
        355                 360                 365             


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
    370                 375                 380                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
385                 390                 395                 400 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                405                 410                 415     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            420                 425                 430         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        435                 440                 445             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    450                 455                 460                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
465                 470                 475                 480 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490                 495 


<210>  101
<211>  2142
<212>  DNA
<213>  Artificial

<220>
<223>  D158 (BCMA 4-45 CD8 BBz 2A TGFBRIIdn)

<400>  101
atgctgctgc tggtgaccag cctgctgctg tgcgaactgc cgcatccggc gtttctgctg       60

attccggagg tgcagctggt gcagtctggg gctgaggtga agaagcctgg ggcctcagtg      120

aaggtttcct gcaaggcatc tggatacacc tccaccagct actatatgca ctgggtgcga      180

caggcccctg gacaagggct tgagtggatg ggaataatca accctagtgg tggtagcaca      240

agctacgcac agaagttcca gggcagagtc accatgacca gggacacgtc cacgagcaca      300

gtctacatgg agctgagcag cttgagatct gaggacacgg ccgtgtatta ctgtgcgaga      360

gatttgggtg atggcgcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

ggaggtggcg ggtctggtgg aggcggtagc ggtggtggcg gatccgacat ccagatgacc      480

cagtctctat cctccctgtc tgcatctgta ggagacagag tcaccatcgc ttgccgggca      540

agtcagacca ttagtaggta tttaaattgg tatcagcaga aaccagggaa agcccctaag      600

ctcctgatct atgctgcatc cagtttgcaa agtggggtct catcaaggtt cagtggcagt      660

ggatctggga cagagttcac tctcaccatc agcagtctgc agcctgaaga ttttgcaact      720

tatttctgtc aacagactta cagtcccccg atcaccttcg gccaagggac acgactggag      780

attaaacgag cggccgctac cacaacccct gcgccccggc ctcctacccc cgcacccacg      840

attgcttctc aacctctttc actccgacct gaggcttgta gacctgcagc cgggggtgcc      900

gtccacacac ggggactcga cttcgcttgt gatatatata tttgggcgcc cctggccggc      960

acttgtggag ttcttttgct ctctcttgtt atcacattgt actgcaagcg aggtaggaag     1020

aaattgcttt acatttttaa gcagccgttc atgcgaccag tacagactac tcaagaagaa     1080

gatgggtgct cttgtcggtt cccggaagaa gaagagggtg gttgcgagtt gagggtgaag     1140

ttctcccgct ctgccgacgc accggcatat cagcagggac aaaaccagct ctacaacgaa     1200

ttgaacctgg gtcggcggga agaatatgac gtgctcgata agcggcgggg tcgcgaccca     1260

gaaatgggag gcaaaccgcg caggaaaaat ccacaggagg gactttataa cgaacttcaa     1320

aaggataaga tggcagaggc atacagcgaa atcgggatga aaggcgagag aagaaggggg     1380

aaagggcacg atggtcttta ccaggggctt tctaccgcga cgaaggatac ctacgatgct     1440

ctccatatgc aagcacttcc tcctagacgg gcaaagcggg gctcaggggc gactaacttt     1500

tcactgttga agcaggccgg ggatgtggag gagaatcctg gtcctagagc taagcgagta     1560

gacatgggaa gagggctgct ccgaggcttg tggccgttgc atattgtatt gtggacgcgg     1620

atagcgagta caatcccgcc tcacgtgcaa aaatcagtta ataacgacat gatcgttact     1680

gacaacaatg gcgcagttaa atttccgcag ctttgtaaat tctgtgatgt aagattttca     1740

acgtgcgata accagaaaag ctgtatgtcc aactgcagca tcacatcaat ctgtgaaaaa     1800

ccccaagagg tatgtgtggc cgtctggcga aagaatgacg aaaatatcac actggagacc     1860

gtttgtcacg atcctaaact cccttatcat gactttattc tggaagacgc agcgtcaccg     1920

aagtgtataa tgaaagagaa gaagaagcct ggagagacgt ttttcatgtg cagttgctcc     1980

tcagatgagt gtaatgacaa catcattttt tccgaggagt acaatacgag taacccagac     2040

ctcctgctgg ttattttcca ggtaaccggc atcagtttgt tgcccccact gggtgttgca     2100

atcagtgtaa taatcatatt ttattgttac cgggtgtgat aa                        2142


<210>  102
<211>  712
<212>  PRT
<213>  Artificial

<220>
<223>  D158 (BCMA 4-45 CD8 BBz 2A TGFBRIIdn)

<400>  102

Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Val Gln Ser Gly Ala Glu 
            20                  25                  30          


Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Tyr Thr Ser Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Gln Gly Leu Glu Trp Met Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Ser Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Met Thr Arg Asp Thr 
                85                  90                  95      


Ser Thr Ser Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Gly Asp Gly Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
145                 150                 155                 160 


Gln Ser Leu Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
                165                 170                 175     


Ala Cys Arg Ala Ser Gln Thr Ile Ser Arg Tyr Leu Asn Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
        195                 200                 205             


Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    210                 215                 220                 


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile Thr Phe Gly Gln Gly 
                245                 250                 255     


Thr Arg Leu Glu Ile Lys Arg Ala Ala Ala Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
305                 310                 315                 320 


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys 
                325                 330                 335     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            340                 345                 350         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        355                 360                 365             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    370                 375                 380                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
385                 390                 395                 400 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                405                 410                 415     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg Arg Ala Lys Arg Gly Ser Gly 
                485                 490                 495     


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
            500                 505                 510         


Pro Gly Pro Arg Ala Lys Arg Val Asp Met Gly Arg Gly Leu Leu Arg 
        515                 520                 525             


Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg Ile Ala Ser Thr 
    530                 535                 540                 


Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr 
545                 550                 555                 560 


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
                565                 570                 575     


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
            580                 585                 590         


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
        595                 600                 605             


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
    610                 615                 620                 


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
625                 630                 635                 640 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
                645                 650                 655     


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
            660                 665                 670         


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
        675                 680                 685             


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
    690                 695                 700                 


Ile Ile Phe Tyr Cys Tyr Arg Val 
705                 710         


<210>  103
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Binder 4-1c VH

<400>  103
gaggtgcagc tggtggagac cgggggaggc gtggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcattt atacggtatg atggaagtaa taaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagattgg      300

gatacgtatt actatgatag tagtggttat gatcgggcct ggggccaggg aaccctggtc      360

accgtctcct ca                                                          372


<210>  104
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Binder 4-1c VH

<400>  104

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Trp Asp Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Asp Arg 
            100                 105                 110         


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  105
<211>  326
<212>  DNA
<213>  Artificial

<220>
<223>  Binder 4-1c VL

<400>  105
gacatccaga tgacccagtc tccctcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc aggcgagtca ggacattaac aactatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtctcatca      180

aggttcagtg gcagtggatc tgggacagag ttcactctca ccatcagcag tctgcagcct      240

gaagattttg caacttattt ctgtcaacag acttacagtc ccccgatcac cttcggccaa      300

gggacacgac tggagattaa acgagc                                           326


<210>  106
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Binder 4-1c VL

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Ser Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Thr Tyr Ser Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg 
            100                 105             


<210>  107
<211>  90
<212>  DNA
<213>  Artificial

<220>
<223>  Furin P2A Furin

<400>  107
cgggcaaagc ggggctcagg ggcgactaac ttttcactgt tgaagcaggc cggggatgtg       60

gaggagaatc ctggtcctag agctaagcga                                        90


<210>  108
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Furin P2A Furin

<400>  108

Arg Ala Lys Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
1               5                   10                  15      


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Arg Ala Lys Arg 
            20                  25                  30  


<210>  109
<211>  573
<212>  DNA
<213>  Artificial

<220>
<223>  TGFBRIIdn

<400>  109
atgggaagag ggctgctccg aggcttgtgg ccgttgcata ttgtattgtg gacgcggata       60

gcgagtacaa tcccgcctca cgtgcaaaaa tcagttaata acgacatgat cgttactgac      120

aacaatggcg cagttaaatt tccgcagctt tgtaaattct gtgatgtaag attttcaacg      180

tgcgataacc agaaaagctg tatgtccaac tgcagcatca catcaatctg tgaaaaaccc      240

caagaggtat gtgtggccgt ctggcgaaag aatgacgaaa atatcacact ggagaccgtt      300

tgtcacgatc ctaaactccc ttatcatgac tttattctgg aagacgcagc gtcaccgaag      360

tgtataatga aagagaagaa gaagcctgga gagacgtttt tcatgtgcag ttgctcctca      420

gatgagtgta atgacaacat cattttttcc gaggagtaca atacgagtaa cccagacctc      480

ctgctggtta ttttccaggt aaccggcatc agtttgttgc ccccactggg tgttgcaatc      540

agtgtaataa tcatatttta ttgttaccgg gtg                                   573


<210>  110
<211>  191
<212>  PRT
<213>  Artificial

<220>
<223>  TGFBRIIdn

<400>  110

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val 
            20                  25                  30          


Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro 
        35                  40                  45              


Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln 
    50                  55                  60                  


Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro 
65                  70                  75                  80  


Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr 
                85                  90                  95      


Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile 
            100                 105                 110         


Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys 
        115                 120                 125             


Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn 
    130                 135                 140                 


Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu 
145                 150                 155                 160 


Leu Leu Val Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu 
                165                 170                 175     


Gly Val Ala Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val 
            180                 185                 190     


