                         SEQUENCE LISTING

<110>  ELI LILLY AND COMPANY
 
<120>  COMPOUNDS AND METHODS TARGETING HUMAN TAU

<130>  X22196_WO

<150>  62/855,331
<151>  2019-05-31

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  2
<211>  433
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Pro Ser Trp Tyr Gly 
            20                  25                  30          


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Leu Arg Ala Gly Ser His Thr Tyr Tyr Ala Gly Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Ala Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Gly Ser Val Gly 
                85                  90                  95      


Arg Gly Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Pro Ser Val Phe Pro Leu Ala Pro Cys Cys Gly Asp Thr 
        115                 120                 125             


Pro Ser Ser Thr Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Leu Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Thr Leu Thr Asn Gly Val 
145                 150                 155                 160 


Arg Thr Phe Pro Ser Val Arg Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
                165                 170                 175     


Ser Val Val Ser Val Thr Ser Ser Ser Gln Pro Val Thr Cys Asn Val 
            180                 185                 190         


Ala His Pro Ala Thr Asn Thr Lys Val Asp Lys Thr Val Ala Pro Ser 
        195                 200                 205             


Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly Pro 
    210                 215                 220                 


Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
225                 230                 235                 240 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp Asp 
                245                 250                 255     


Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg Thr 
            260                 265                 270         


Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg Val 
        275                 280                 285             


Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys Glu 
    290                 295                 300                 


Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
305                 310                 315                 320 


Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr Thr 
                325                 330                 335     


Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu Thr 
            340                 345                 350         


Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu 
        355                 360                 365             


Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val Leu 
    370                 375                 380                 


Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro Thr 
385                 390                 395                 400 


Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His Glu 
                405                 410                 415     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro Gly 
            420                 425                 430         


Lys 
    


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Pro Ser Trp Tyr Gly 
            20                  25                  30          


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Leu Arg Ala Gly Ser His Thr Tyr Tyr Ala Gly Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Ala Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Gly Ser Val Gly 
                85                  90                  95      


Arg Gly Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 
            100                 105                 110 


<210>  4
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Thr Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Leu Ala Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Leu Ala Ser Ser Leu Ser Ser Gly Val Ser Ser His Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Ala Asp Asp Ala Ala Thr Tyr Phe Cys Gln Gly Ser Tyr Asp Cys 
                85                  90                  95      


Thr Ile Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Gly Asp Pro Val Ala Pro Thr Val Leu Ile Phe Pro Pro Ala Ala 
        115                 120                 125             


Asp Gln Val Ala Thr Gly Thr Val Thr Ile Val Cys Val Ala Asn Lys 
    130                 135                 140                 


Tyr Phe Pro Asp Val Thr Val Thr Trp Glu Val Asp Gly Thr Thr Gln 
145                 150                 155                 160 


Thr Thr Gly Ile Glu Asn Ser Lys Thr Pro Gln Asn Ser Ala Asp Asn 
                165                 170                 175     


Thr Tyr Asn Leu Ser Ser Thr Leu Thr Leu Thr Ser Thr Gln Tyr Asn 
            180                 185                 190         


Ser His Lys Glu Tyr Thr Cys Lys Val Thr Gln Gly Thr Thr Ser Val 
        195                 200                 205             


Val Gln Ser Phe Asn Arg Gly Asp Cys 
    210                 215         


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Thr Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Leu Ala Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Leu Ala Ser Ser Leu Ser Ser Gly Val Ser Ser His Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Ala Asp Asp Ala Ala Thr Tyr Phe Cys Gln Gly Ser Tyr Asp Cys 
                85                  90                  95      


Thr Ile Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  6
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Pro Ser Trp Tyr Gly 
            20                  25                  30          


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Leu Arg Ala Gly Ser His Thr Tyr Tyr Ala Gly Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Ala Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Gly Ser Val Gly 
                85                  90                  95      


Arg Gly Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu 
            100                 105                 110 


<210>  7
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Leu Ser Pro Ser Trp Tyr Gly 
            20                  25                  30          


Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Val Leu Arg Ala Gly Ser His Thr Tyr Tyr Ala Gly Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Ala Ile Ser Lys Thr Ser Thr Thr Val Ala Leu Lys Ile Thr 
65                  70                  75                  80  


Ser Pro Thr Thr Glu Asp Thr Ala Ile Tyr Phe Cys Gly Ser Val Gly 
                85                  90                  95      


Arg Gly Ile Trp Gly Pro Gly Thr Leu Val Thr Val Ser Leu Ala Lys 
            100                 105                 110         


Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln 
        115                 120                 125             


Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro 
    130                 135                 140                 


Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val 
145                 150                 155                 160 


His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser 
                165                 170                 175     


Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val Thr Cys 
            180                 185                 190         


Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Val 
        195                 200                 205             


Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val 
    210                 215                 220                 


Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile 
225                 230                 235                 240 


Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp 
                245                 250                 255     


Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His 
            260                 265                 270         


Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
        275                 280                 285             


Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr 
                325                 330                 335     


Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu 
            340                 345                 350         


Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp 
        355                 360                 365             


Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile 
    370                 375                 380                 


Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln 
385                 390                 395                 400 


Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His 
                405                 410                 415     


Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro 
            420                 425                 430         


Gly Lys 
        


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Thr Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Leu Ala Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Leu Ala Ser Ser Leu Ser Ser Gly Val Ser Ser His Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Ala Asp Asp Ala Ala Thr Tyr Phe Cys Gln Gly Ser Tyr Asp Cys 
                85                  90                  95      


Thr Ile Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys 
    


<210>  9
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Ala Gln Val Leu Thr Gln Thr Ala Ser Pro Val Ser Ala Thr Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ala Ser Leu Ala Val Tyr Asn Asn 
            20                  25                  30          


Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Arg 
        35                  40                  45              


Leu Ile Tyr Leu Ala Ser Ser Leu Ser Ser Gly Val Ser Ser His Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Ala Asp Asp Ala Ala Thr Tyr Phe Cys Gln Gly Ser Tyr Asp Cys 
                85                  90                  95      


Thr Ile Ala Asp Cys Val Ala Phe Gly Gly Gly Thr Glu Val Val Val 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu 
145                 150                 155                 160 


Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr 
            180                 185                 190         


Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr 
        195                 200                 205             


Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 220 


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10

Gly Leu Ser Pro Ser Trp Tyr Gly Val His 
1               5                   10  


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Val Leu Arg Ala Gly Ser His Thr Tyr Tyr Ala Gly Trp Ala Lys Gly 
1               5                   10                  15      


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Val Gly Arg Gly Ile 
1               5   


<210>  13
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Gln Ala Ser Leu Ala Val Tyr Asn Asn Asn Tyr Leu Ala 
1               5                   10              


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Leu Ala Ser Ser Leu Ser Ser 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Leu Ala Ser Ser Leu Ser Ser 
1               5           


<210>  16
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Asp Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Trp Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Phe Asp Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
        115                 120                 125             


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
                165                 170                 175     


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
            180                 185                 190         


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
        195                 200                 205             


Arg Val Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys 
    210                 215                 220                 


Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro 
225                 230                 235                 240 


Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser 
            260                 265                 270         


Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His 
        275                 280                 285             


Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile 
    290                 295                 300                 


Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn 
305                 310                 315                 320 


Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys 
                325                 330                 335     


Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu 
            340                 345                 350         


Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe 
        355                 360                 365             


Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu 
    370                 375                 380                 


Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr 
385                 390                 395                 400 


Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg 
                405                 410                 415     


Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His 
            420                 425                 430         


Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        435                 440             


<210>  17
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Asp Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Trp Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Asn Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Phe Asp Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  18
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Val Ser Arg Arg Ala Phe Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ala Ser Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  19
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Arg Ser Asn 
            20                  25                  30          


Tyr Phe Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Val Ser Arg Arg Ala Phe Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ala Ser Leu 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  20
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Ala Val Tyr Gly Gly Ser Phe Ser Pro Tyr Tyr Trp Ser 
1               5                   10              


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  21

Glu Ile Asn Trp Ser Gly Asp Thr Asn 
1               5                   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  22

Ala Arg Ser Phe Asp Arg 
1               5       


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  23

Arg Ala Ser Gln Ser Val Arg Ser Asn Tyr Phe Ala 
1               5                   10          


<210>  24
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  24

Tyr Gly Val Ser Arg Arg Ala Phe 
1               5               


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  25

Gln Gln Tyr Gly Ala Ser Leu Ile Thr 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  wherein T at residue 7 is phosphorylated

<400>  26

Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg 
1               5                   10      


<210>  27
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  27

Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly Thr 
1               5                   10                  15      


Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His Gln 
            20                  25                  30          


Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu Gln 
        35                  40                  45              


Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser Asp 
    50                  55                  60                  


Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val Asp 
65                  70                  75                  80  


Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu Ile 
                85                  90                  95      


Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro Ser 
            100                 105                 110         


Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Glu Pro Glu Ser Gly 
        115                 120                 125             


Lys Val Val Gln Glu Gly Phe Leu Arg Glu Pro Gly Pro Pro Gly Leu 
    130                 135                 140                 


Ser His Gln Leu Met Ser Gly Met Pro Gly Ala Pro Leu Leu Pro Glu 
145                 150                 155                 160 


Gly Pro Arg Glu Ala Thr Arg Gln Pro Ser Gly Thr Gly Pro Glu Asp 
                165                 170                 175     


Thr Glu Gly Gly Arg His Ala Pro Glu Leu Leu Lys His Gln Leu Leu 
            180                 185                 190         


Gly Asp Leu His Gln Glu Gly Pro Pro Leu Lys Gly Ala Gly Gly Lys 
        195                 200                 205             


Glu Arg Pro Gly Ser Lys Glu Glu Val Asp Glu Asp Arg Asp Val Asp 
    210                 215                 220                 


Glu Ser Ser Pro Gln Asp Ser Pro Pro Ser Lys Ala Ser Pro Ala Gln 
225                 230                 235                 240 


Asp Gly Arg Pro Pro Gln Thr Ala Ala Arg Glu Ala Thr Ser Ile Pro 
                245                 250                 255     


Gly Phe Pro Ala Glu Gly Ala Ile Pro Leu Pro Val Asp Phe Leu Ser 
            260                 265                 270         


Lys Val Ser Thr Glu Ile Pro Ala Ser Glu Pro Asp Gly Pro Ser Val 
        275                 280                 285             


Gly Arg Ala Lys Gly Gln Asp Ala Pro Leu Glu Phe Thr Phe His Val 
    290                 295                 300                 


Glu Ile Thr Pro Asn Val Gln Lys Glu Gln Ala His Ser Glu Glu His 
305                 310                 315                 320 


Leu Gly Arg Ala Ala Phe Pro Gly Ala Pro Gly Glu Gly Pro Glu Ala 
                325                 330                 335     


Arg Gly Pro Ser Leu Gly Glu Asp Thr Lys Glu Ala Asp Leu Pro Glu 
            340                 345                 350         


Pro Ser Glu Lys Gln Pro Ala Ala Ala Pro Arg Gly Lys Pro Val Ser 
        355                 360                 365             


Arg Val Pro Gln Leu Lys Ala Arg Met Val Ser Lys Ser Lys Asp Gly 
    370                 375                 380                 


Thr Gly Ser Asp Asp Lys Lys Ala Lys Thr Ser Thr Arg Ser Ser Ala 
385                 390                 395                 400 


Lys Thr Leu Lys Asn Arg Pro Cys Leu Ser Pro Lys His Pro Thr Pro 
                405                 410                 415     


Gly Ser Ser Asp Pro Leu Ile Gln Pro Ser Ser Pro Ala Val Cys Pro 
            420                 425                 430         


Glu Pro Pro Ser Ser Pro Lys Tyr Val Ser Ser Val Thr Ser Arg Thr 
        435                 440                 445             


Gly Ser Ser Gly Ala Lys Glu Met Lys Leu Lys Gly Ala Asp Gly Lys 
    450                 455                 460                 


Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro Gly Gln Lys Gly 
465                 470                 475                 480 


Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro Pro Ala Pro Lys 
                485                 490                 495     


Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly 
            500                 505                 510         


Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg Thr 
        515                 520                 525             


Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys Lys Val Ala Val 
    530                 535                 540                 


Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys Ser Arg Leu Gln 
545                 550                 555                 560 


Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val Lys Ser Lys Ile 
                565                 570                 575     


Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly Gly Lys Val Gln 
            580                 585                 590         


Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln Ser Lys Cys Gly 
        595                 600                 605             


Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly Ser Val Gln Ile 
    610                 615                 620                 


Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser Lys Cys Gly Ser 
625                 630                 635                 640 


Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln Val Glu Val Lys 
                645                 650                 655     


Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser Lys Ile Gly Ser 
            660                 665                 670         


Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn Lys Lys Ile Glu 
        675                 680                 685             


Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala Lys Thr Asp His 
    690                 695                 700                 


Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser Gly Asp Thr Ser 
705                 710                 715                 720 


Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser Ile Asp Met Val 
                725                 730                 735     


Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val Ser Ala Ser Leu 
            740                 745                 750         


Ala Lys Gln Gly Leu 
        755         


