                               SEQUENCE LISTING

<110> MEMORIAL SLOAN KETTERING CANCER CENTER
 
<120> ANTI-GLYPICAN-3 ANTIBODIES AND USES THEREOF

<130> 115872-0999

<140> PCT/US2020/034177
<141> 2020-05-22

<150> 62/852,837
<151> 2019-05-24

<160> 92    

<170> PatentIn version 3.5

<210> 1
<211> 117
<212> PRT
<213> Mus sp.

<400> 1
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 2
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 3
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 4
<211> 113
<212> PRT
<213> Mus sp.

<400> 4
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210> 5
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
1               5                   10                  15      


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210> 6
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu 
1               5                   10                  15      


Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser 
            20                  25                  30          


Asn Gln Lys Asn Tyr Leu Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
                85                  90                  95      


Asn Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210> 7
<211> 1392
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga ggtgcagctg       60

gtggaatctg gcggaggact ggtgcagcct gagggctccc tgaagctgtc ttgtgccgcc      120

tccggcttca ccttcaacaa gaacgccatg aactgggtgc gacaggcccc tggcaagggc      180

ctggaatggg tggcccggat cagaaacaag accaacaact acgccaccta ctacgccgac      240

tccgtgaagg cccggttcac catctctcgg gacgactccc agtccatgct gtacctgcag      300

atgaacagcc tgaagatcga ggacaccgcc atgtactact gcgtggccgg caactccttc      360

gcctattggg gccagggcac cctcgtgacc gtgtcctctg cttctaccaa gggcccatcg      420

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      480

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      540

agcggcgtgc acaccttccc ggccgtccta cagtcctcag gactctactc cctcagcagc      600

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      660

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac      720

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      840

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      960

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1020

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ga                                                         1392


<210> 8
<211> 1392
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga ggtgcagctg       60

gtggaatctg gcggaggact ggtgcagcct ggcggctctc tgaagctgtc ttgtgccgcc      120

tccggcttca ccttcaacaa gaacgccatg aactgggtgc gacaggcccc tggcaagggc      180

ctggaatggg tggcccggat cagaaacaag accaacaact acgccaccta ctacgccgac      240

tccgtgaagg cccggttcac catctctcgg gacgactcca agaacaccct gtacctgcag      300

atgaactccc tgaagatcga ggacaccgcc gtgtactact gcgtggccgg caactccttt      360

gcctactggg gccagggcac cctcgtgacc gtgtcctctg cttctaccaa gggcccatcg      420

gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc      480

ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc      540

agcggcgtgc acaccttccc ggccgtccta cagtcctcag gactctactc cctcagcagc      600

gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac      660

aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac      720

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      780

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      840

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      900

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      960

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc     1020

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga     1080

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc     1140

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat     1200

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1260

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca     1320

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct     1380

ccgggtaaat ga                                                         1392


<210> 9
<211> 714
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga catcgtgatg       60

acccagtccc cctcctccct ggtggtgtcc attggcgagc gcgtgaccat gaactgcaag      120

tcctcccagt ccctgctgta ctcctccaac cagaagaact acctggcctg gtatcagcag      180

aagcccggcc agtcccctaa gctgctgatc tactgggcct ccagccgcga ggcttctggc      240

gtgcccgata gattctccgg ctctggctct ggcaccgact ttaccctgac catctcctcc      300

gtgaaggccg aggacgtggc cgtgtactac tgccagcagt actacaacta ccccctgacc      360

ttcggcgctg gcaccaagct ggaactgaag agaaccgtgg ccgctccctc cgtgttcatc      420

ttcccacctt ccgacgagca gctgaagtcc ggcaccgctt ctgtcgtgtg cctgctgaac      480

aacttctacc cccgcgaggc caaggtgcag tggaaggtgg acaacgccct gcagtccggc      540

aactcccagg aatccgtgac cgagcaggac tccaaggaca gcacctactc cctgtcctcc      600

accctgaccc tgtccaaggc cgactacgag aagcacaagg tgtacgcctg cgaagtgacc      660

caccagggcc tgtctagccc cgtgaccaag tctttcaacc ggggcgagtg ctag            714


<210> 10
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga catcgtgatg       60

acccagagcc ctgactccct ggccgtgtct ctgggcgagc gcgtgaccat gaactgcaag      120

tcctcccagt ccctgctgta ctcctccaac cagaaaaact acctgtggta tcagcagaag      180

cccggccagt cccccaagct gctgatctac tgggcctcct ccagagaagc ctctggcgtg      240

cccgacagat tctccggctc tggctctggc accgacttta ccctgaccat ctccagcgtg      300

caggccgagg atgtggccgt gtactactgc cagcagtact acaactaccc cctgaccttc      360

ggccagggca ccaagctgga actgaagaga accgtggccg ctccctccgt gttcatcttc      420

ccaccttccg acgagcagct gaagtccggc accgcttctg tcgtgtgcct gctgaacaac      480

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gtccggcaac      540

tcccaggaat ccgtgaccga gcaggactcc aaggacagca cctactccct gtcctccacc      600

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacccac      660

cagggcctgt ctagccccgt gaccaagtct ttcaaccggg gcgagtgcta g               711


<210> 11
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210> 12
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met 
                325                 330                 335     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                405                 410                 415     


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
            420                 425                 430         


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
        435                 440                 445             


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                485                 490                 495     


Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505                 


<210> 13
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210> 14
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 15
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
                245                 250                 255     


Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Gly Tyr Ile 
    290                 295                 300                 


Asn Pro Ser Arg Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Asp Arg 
305                 310                 315                 320 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ala Phe Leu Gln Met 
                325                 330                 335     


Asp Ser Leu Arg Pro Glu Asp Thr Gly Val Tyr Phe Cys Ala Arg Tyr 
            340                 345                 350         


Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Pro Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
                405                 410                 415     


Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser 
            420                 425                 430         


Tyr Met Asn Trp Tyr Gln Gln Thr Pro Gly Lys Ala Pro Lys Arg Trp 
        435                 440                 445             


Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    450                 455                 460                 


Gly Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln 
465                 470                 475                 480 


Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro 
                485                 490                 495     


Phe Thr Phe Gly Cys Gly Thr Lys Leu Gln Ile Thr Arg 
            500                 505                 


<210> 16
<211> 1530
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga catcgtgatg       60

acccagtccc cctcctccct ggtggtgtcc attggcgagc gcgtgaccat gaactgcaag      120

tcctcccagt ccctgctgta ctcctccaac cagaagaact acctggcctg gtatcagcag      180

aagcccggcc agtcccctaa gctgctgatc tactgggcct ccagccgcga gtctggcgtg      240

cccgatagat tctccggctc tggctctggc accgacttta ccctgaccat ctcctccgtg      300

aaggccgagg acgtggccgt gtactactgc cagcagtact acaactaccc cctgaccttc      360

ggcgctggca ccaagctgga actgaagaga accgtggccg ctccctccgt gttcatcttc      420

ccaccttccg acgagcagct gaagtccggc accgcttctg tcgtgtgcct gctgaacaac      480

ttctaccccc gcgaggccaa ggtgcagtgg aaggtggaca acgccctgca gtccggcaac      540

tcccaggaat ccgtgaccga gcaggactcc aaggacagca cctactccct gtcctccacc      600

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga agtgacccac      660

cagggcctgt ctagccccgt gaccaagtct ttcaaccggg gcgagtgcac tagtggcggc      720

ggaggatctg gcggaggtgg aagcggaggg ggaggatctc aggtgcagct ggtgcagagc      780

ggaggcggag tggtgcagcc tggcagatcc ctgagactgt cctgcaaggc ctccggctac      840

accttcaccc ggtacaccat gcactgggtg cgacaggccc ctggcaagtg cctggaatgg      900

atcggctaca tcaacccctc ccggggctac accaactaca accagaagtt caaggaccgg      960

ttcaccatct cccgggacaa ctccaagaac accgcctttc tgcagatgga ctccctgcgg     1020

cctgaggata ccggcgtgta cttctgcgcc cggtactacg acgaccacta ctccctggac     1080

tactggggcc agggaacccc tgtgacagtg tcatctggtg gcggaggaag tgggggaggc     1140

ggatcaggtg gtggtggatc aggcggggga ggttcagggg gtggcggttc tgggggaggg     1200

ggctctgata ttcagatgac tcagagccct tccagcctga gcgcctccgt gggagatcgc     1260

gtgacaatta cctgctctgc ctcctcctcc gtgtcttaca tgaattggta tcagcagacc     1320

cctgggaagg ctcctaagcg gtggatctac gacacctcca agctggcctc tggcgtgccc     1380

agcaggtttt ctggctccgg cagcggcaca gattatacct tcaccatcag ctccctgcag     1440

ccagaagata tcgctaccta ttattgtcag cagtggtcct ccaacccttt caccttcggc     1500

tgcggcacaa agctgcagat cacaagatag                                      1530


<210> 17
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 18
<211> 1392
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
atgggctggt cctgcatcat cctgtttctg gtggctaccg ccaccggcga ggtgcagctg       60

gtggaatctg gcggaggact ggtgcagcct gagggctccc tgaagctgtc ttgtgccgcc      120

tccggcttca ccttcaacaa gaacgccatg aactgggtgc gacaggcccc tggcaagggc      180

ctggaatggg tggcccggat cagaaacaag accaacaact acgccaccta ctacgccgac      240

tccgtgaagg cccggttcac catctctcgg gacgactccc agtccatgct gtacctgcag      300

atgaacagcc tgaagatcga ggacaccgcc atgtactact gcgtggccgg caactccttc      360

gcctattggg gccagggcac cctcgtgacc gtgtcctctg cttctaccaa gggcccctct      420

gtgtttcctc tggccccctc cagcaagtcc acctctggtg gaacagccgc cctgggctgc      480

ctcgtgaagg actactttcc cgagcccgtg accgtgtcct ggaactctgg cgctctgacc      540

tctggcgtgc acaccttccc tgctgtgctg cagtctagcg gcctgtactc cctgtcctcc      600

gtcgtgacag tgccctccag ctctctgggc acccagacct acatctgcaa cgtgaaccac      660

aagccctcca ataccaaggt ggacaagcgg gtggaaccca agtcctgcga caagacccac      720

acctgtcccc cttgtcctgc ccctgaactg ctgggcggac cttccgtgtt cctgttcccc      780

ccaaagccca aggacaccct gatgatctcc cggacccccg aagtgacctg cgtggtggtg      840

gatgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg      900

cacaacgcca agaccaagcc tagagaggaa cagtacgcct ccacctaccg ggtggtgtcc      960

gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg cgccgtgtcc     1020

aacaaggccc tgcctgcccc catcgaaaag accatctcca aggccaaggg ccagccccgg     1080

gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa ccaggtgtcc     1140

ctgacctgtc tcgtgaaagg cttctacccc tccgatatcg ccgtggaatg ggagtccaac     1200

ggccagcctg agaacaacta caagaccacc ccccctgtgc tggactccga cggctcattc     1260

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttctcc     1320

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gtccctgagc     1380

cccggcaaat ga                                                         1392


<210> 19
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Lys 
                245                 250                 255     


Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser 
            260                 265                 270         


Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
        275                 280                 285             


Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile 
    290                 295                 300                 


Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Leu 
305                 310                 315                 320 


Asn Ile Tyr Arg Asp Asn Ser Lys Asn Gln Val Phe Leu Glu Met Asn 
                325                 330                 335     


Ser Leu Gln Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly 
            340                 345                 350         


Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ala Val Val Ile Gln Glu Ser Ala Leu Thr Thr Pro Pro 
                405                 410                 415     


Gly Glu Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr 
            420                 425                 430         


Ala Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Cys Phe 
        435                 440                 445             


Thr Gly Leu Ile Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ala 
465                 470                 475                 480 


Gly Thr Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr 
                485                 490                 495     


Ser Asp His Trp Val Ile Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            500                 505                 510         


<210> 20
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 21
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile 
    290                 295                 300                 


Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe 
305                 310                 315                 320 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                325                 330                 335     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly 
            340                 345                 350         


Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                405                 410                 415     


Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr 
            420                 425                 430         


Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro 
        435                 440                 445             


Arg Gly Leu Ile Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu 
465                 470                 475                 480 


Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr 
                485                 490                 495     


Ser Asp His Trp Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505                 510         


<210> 22
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 23
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 24
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala 
    610         


<210> 25
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635         


<210> 26
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala 
625                 630 


<210> 27
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala Pro His His His His His His 
625                 630         


<210> 28
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala 
625 


<210> 29
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 30
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala 
    610         


<210> 31
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635         


<210> 32
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala 
625                 630 


<210> 33
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala Pro His His His His His His 
625                 630         


<210> 34
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Thr Gly Gly Gly Met Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Asn Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala 
625 


<210> 35
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Lys 
                245                 250                 255     


Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser 
            260                 265                 270         


Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
        275                 280                 285             


Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile 
    290                 295                 300                 


Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Leu 
305                 310                 315                 320 


Asn Ile Tyr Arg Asp Asn Ser Lys Asn Gln Val Phe Leu Glu Met Asn 
                325                 330                 335     


Ser Leu Gln Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Gly 
            340                 345                 350         


Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Thr Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ala Val Val Ile Gln Glu Ser Ala Leu Thr Thr Pro Pro 
                405                 410                 415     


Gly Glu Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr 
            420                 425                 430         


Ala Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Cys Phe 
        435                 440                 445             


Thr Gly Leu Ile Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Ala 
465                 470                 475                 480 


Gly Thr Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr 
                485                 490                 495     


Ser Asp His Trp Val Ile Gly Gly Gly Thr Arg Leu Thr Val Leu Gly 
            500                 505                 510         


<210> 36
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 37
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Thr Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln 
                245                 250                 255     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            260                 265                 270         


Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His 
        275                 280                 285             


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile 
    290                 295                 300                 


Trp Ser Gly Gly Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe 
305                 310                 315                 320 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
                325                 330                 335     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly 
            340                 345                 350         


Ser Tyr Pro Tyr Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val 
        355                 360                 365             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    370                 375                 380                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Ala Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro 
                405                 410                 415     


Gly Gly Thr Val Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr 
            420                 425                 430         


Ala Ser Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro 
        435                 440                 445             


Arg Gly Leu Ile Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala 
    450                 455                 460                 


Arg Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu 
465                 470                 475                 480 


Gly Ala Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr 
                485                 490                 495     


Ser Asp His Trp Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            500                 505                 510         


<210> 38
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 39
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 40
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala 
    610         


<210> 41
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635         


<210> 42
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala 
625                 630 


<210> 43
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala Pro His His His His His His 
625                 630         


<210> 44
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala 
625 


<210> 45
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 46
<211> 612
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala 
    610         


<210> 47
<211> 637
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala Pro His His His His His His 
625                 630                 635         


<210> 48
<211> 630
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg Ser Pro Asp Asp Glu Leu Leu Tyr 
                565                 570                 575     


Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu Leu Lys Ile Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Gln Tyr Leu Pro Gln His Thr Ile Glu Thr 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu Leu Gln Lys Gln 
    610                 615                 620                 


Gly Gly Ser Gly Gly Ala 
625                 630 


<210> 49
<211> 632
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala Pro His His His His His His 
625                 630         


<210> 50
<211> 625
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Arg His Gly Asp Glu Asp Thr Tyr Tyr 
                565                 570                 575     


Leu Gln Val Arg Gly Arg Glu Asn Phe Glu Ile Leu Met Lys Leu Lys 
            580                 585                 590         


Glu Ser Leu Glu Leu Met Glu Leu Val Pro Gln Pro Leu Val Asp Ser 
        595                 600                 605             


Tyr Arg Gln Gln Gln Gln Leu Leu Gln Arg Pro Gly Gly Ser Gly Gly 
    610                 615                 620                 


Ala 
625 


<210> 51
<211> 384
<212> PRT
<213> Homo sapiens

<400> 51
Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210> 52
<211> 330
<212> PRT
<213> Homo sapiens

<400> 52
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 53
<211> 326
<212> PRT
<213> Homo sapiens

<400> 53
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210> 54
<211> 377
<212> PRT
<213> Homo sapiens

<400> 54
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210> 55
<211> 452
<212> PRT
<213> Homo sapiens

<400> 55
Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Ala His 
                405                 410                 415     


Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr 
            420                 425                 430         


Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala 
        435                 440                 445             


Gly Thr Cys Tyr 
    450         


<210> 56
<211> 327
<212> PRT
<213> Homo sapiens

<400> 56
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210> 57
<211> 353
<212> PRT
<213> Homo sapiens

<400> 57
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210> 58
<211> 340
<212> PRT
<213> Homo sapiens

<400> 58
Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210> 59
<211> 106
<212> PRT
<213> Homo sapiens

<400> 59
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210> 60
<211> 39
<212> PRT
<213> Homo sapiens

<400> 60
Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
1               5                   10                  15      


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            20                  25                  30          


Ala Gln Ala Gly Lys Glu Pro 
        35                  


<210> 61
<211> 57
<212> PRT
<213> Homo sapiens

<400> 61
Arg Ser Pro Asp Asp Glu Leu Leu Tyr Leu Pro Val Arg Gly Arg Glu 
1               5                   10                  15      


Thr Tyr Glu Met Leu Leu Lys Ile Lys Glu Ser Leu Glu Leu Met Gln 
            20                  25                  30          


Tyr Leu Pro Gln His Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln His Gln His Leu Leu Gln Lys Gln 
    50                  55          


<210> 62
<211> 52
<212> PRT
<213> Homo sapiens

<400> 62
Arg His Gly Asp Glu Asp Thr Tyr Tyr Leu Gln Val Arg Gly Arg Glu 
1               5                   10                  15      


Asn Phe Glu Ile Leu Met Lys Leu Lys Glu Ser Leu Glu Leu Met Glu 
            20                  25                  30          


Leu Val Pro Gln Pro Leu Val Asp Ser Tyr Arg Gln Gln Gln Gln Leu 
        35                  40                  45              


Leu Gln Arg Pro 
    50          


<210> 63
<211> 27
<212> PRT
<213> Homo sapiens

<400> 63
Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp Ser 
1               5                   10                  15      


Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu 
            20                  25          


<210> 64
<211> 54
<212> PRT
<213> Homo sapiens

<400> 64
Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile Glu Ser Gln Asp Ala Gly 
1               5                   10                  15      


Ile Lys Thr Ile Thr Met Leu Asp Glu Gln Lys Glu Gln Leu Asn Arg 
            20                  25                  30          


Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys Asp Met Arg Glu Thr Glu 
        35                  40                  45              


Lys Thr Leu Thr Glu Leu 
    50                  


<210> 65
<211> 97
<212> PRT
<213> Homo sapiens

<400> 65
Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr Gln 
1               5                   10                  15      


His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn Lys 
            20                  25                  30          


Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val Ala 
        35                  40                  45              


Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe Val 
    50                  55                  60                  


His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu Thr 
65                  70                  75                  80  


Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr Tyr 
                85                  90                  95      


Phe 
    


<210> 66
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      KCNQ4 tetramerizaiton domain amino acid sequence 

<400> 66
Asp Glu Ile Ser Met Met Gly Arg Val Val Lys Val Glu Lys Gln Val 
1               5                   10                  15      


Gln Ser Ile Glu His Lys Leu Asp Leu Leu Leu Gly Phe Tyr 
            20                  25                  30  


<210> 67
<211> 60
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CBFA2T1 tetramerizaiton domain amino acid sequence 

<400> 67
Thr Val Ala Glu Ala Lys Arg Gln Ala Ala Glu Asp Ala Leu Ala Val 
1               5                   10                  15      


Ile Asn Gln Gln Glu Asp Ser Ser Glu Ser Cys Trp Asn Cys Gly Arg 
            20                  25                  30          


Lys Ala Ser Glu Thr Cys Ser Gly Cys Asn Thr Ala Arg Tyr Cys Gly 
        35                  40                  45              


Ser Phe Cys Gln His Lys Asp Trp Glu Lys His His 
    50                  55                  60  


<210> 68
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Arg Val Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Asp 
            


<210> 69
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Arg Ile Arg Asn Glu Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ala 
            


<210> 70
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Arg Val Arg Asn Glu Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Ala 
            


<210> 71
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Met 
1               5                   10                  15      


Ala 
    


<210> 72
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Gly Phe Thr Phe Asn Lys Asn Ala 
1               5               


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Val Ala Gly Asn Ser Phe Ala Tyr 
1               5               


<210> 74
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210> 75
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Trp Ala Ser 
1           


<210> 76
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr 
1               5                   


<210> 77
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 77
Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr 
1               5                   10  


<210> 78
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 78
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Cys Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 79
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 79
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Cys Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Cys Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 80
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 80
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val Ser Ile Gly 
            20                  25                  30          


Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
        35                  40                  45              


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
    50                  55                  60                  


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu Ser Gly Val 
65                  70                  75                  80  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu Glu Leu 
        115                 120                 125             


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
                165                 170                 175     


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
            180                 185                 190         


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        195                 200                 205             


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    210                 215                 220                 


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
225                 230                 235                 240 


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
                245                 250                 255     


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            260                 265                 270         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 81
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 81
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Cys Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 82
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Cys Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Cys Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 83
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 84
<211> 619
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 84
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Asn 
        35                  40                  45              


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
    50                  55                  60                  


Ala Arg Ile Arg Asn Lys Thr Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Ala Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Lys Ile Glu Asp Thr Ala Met Tyr 
            100                 105                 110         


Tyr Cys Val Ala Gly Asn Ser Phe Ala Tyr Trp Gly Cys Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Asp Ile Val Met Thr Gln Cys Pro Ser Ser Leu Val Val 
                165                 170                 175     


Ser Ile Gly Glu Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu 
            180                 185                 190         


Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
        195                 200                 205             


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ser Arg Glu 
    210                 215                 220                 


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
225                 230                 235                 240 


Thr Leu Thr Ile Ser Ser Val Lys Ala Glu Asp Val Ala Val Tyr Tyr 
                245                 250                 255     


Cys Gln Gln Tyr Tyr Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
            260                 265                 270         


Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Gly Ser His Val Gln Leu Val Glu Ser 
    290                 295                 300                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
305                 310                 315                 320 


Ala Ser Gly Phe Ser Leu Thr Asp Tyr Gly Val His Trp Val Arg Gln 
                325                 330                 335     


Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly 
            340                 345                 350         


Gly Thr Ala Tyr Asn Thr Ala Leu Ile Ser Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Gly Ser Tyr Pro Tyr 
385                 390                 395                 400 


Asn Tyr Phe Asp Ala Trp Gly Cys Gly Thr Leu Val Thr Val Ser Ser 
                405                 410                 415     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            420                 425                 430         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ala 
        435                 440                 445             


Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly Thr Val 
    450                 455                 460                 


Thr Leu Thr Cys Gly Ser Ser Thr Gly Ala Val Thr Ala Ser Asn Tyr 
465                 470                 475                 480 


Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Cys Pro Arg Gly Leu Ile 
                485                 490                 495     


Gly Gly His Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe Ser Gly 
            500                 505                 510         


Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Leu Gly Ala Gln Pro 
        515                 520                 525             


Glu Asp Glu Ala Glu Tyr Tyr Cys Ala Leu Trp Tyr Ser Asp His Trp 
    530                 535                 540                 


Val Ile Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Thr Pro Leu Gly 
545                 550                 555                 560 


Asp Thr Thr His Thr Ser Gly Lys Pro Leu Asp Gly Glu Tyr Phe Thr 
                565                 570                 575     


Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn 
            580                 585                 590         


Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly Gly 
        595                 600                 605             


Ser Gly Gly Ala Pro His His His His His His 
    610                 615                 


<210> 85
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 85
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30  


<210> 86
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 86
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 87
Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   


<210> 88
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 88
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 89
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE 
<222> (1)..(150)
<223> This sequence may encompass 1-30 "Gly Gly Gly Gly Ser" 
      repeating units

<400> 89
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser 
145                 150 


<210> 90
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 90
His His His His His His 
1               5       


<210> 91
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 91
Gly Gly Gly Gly Ser 
1               5   


<210> 92
<211> 75
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(75)
<223> This sequence may encompass 1-15 "Gly Gly Gly Gly Ser" 
      repeating units

<400> 92
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75  



