                         SEQUENCE LISTING

<110>  ZYMEWORKS BIOPHARMACEUTICALS INC.
 
<120>  METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING
        HER2 FOR THE TREATMENT OF BILIARY TRACT CANCERS

<130>  ZYME063WO

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  607
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HER2

<400>  1

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn 
        595                 600                 605         


<210>  2
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc

<400>  2

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  3
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Lys Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  4
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaagggc tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgaa gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac atgcccccct tgtcctgcac cagagctgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gatacactga tgattagtag gaccccagaa      780

gtcacatgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      840

gtggacggcg tcgaggtgca taatgccaag actaaaccca gggaggaaca gtacaacagt      900

acctatcgcg tcgtgtcagt cctgacagtg ctgcatcagg attggctgaa cgggaaagag      960

tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac aatttccaag     1020

gcaaaaggac agcctagaga accacaggtg tacgtgctgc ctccatcaag ggatgagctg     1080

acaaagaacc aggtcagcct gctgtgtctg gtgaaaggat tctatccctc tgacattgct     1140

gtggagtggg aaagtaatgg ccagcctgag aacaattacc tgacctggcc ccctgtgctg     1200

gactcagatg gcagcttctt tctgtatagc aagctgaccg tcgacaaatc ccggtggcag     1260

caggggaatg tgtttagttg ttcagtcatg cacgaggcac tgcacaacca ttacacccag     1320

aagtcactgt cactgtcacc aggg                                            1344


<210>  5
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  6

Gly Phe Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  7

Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  8

Val Asn Pro Asn Ser Gly Gly Ser 
1               5               


<210>  9
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  10
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  10
gatattcaga tgacccagtc cccaagctcc ctgagtgcct cagtgggcga ccgagtcacc       60

atcacatgca aggcttccca ggatgtgtct attggagtcg catggtacca gcagaagcca      120

ggcaaagcac ccaagctgct gatctatagc gcctcctacc ggtataccgg cgtgccctct      180

agattctctg gcagtgggtc aggaacagac tttactctga ccatctctag tctgcagcct      240

gaggatttcg ctacctacta ttgccagcag tactatatct acccatatac ctttggccag      300

gggacaaaag tggagatcaa gaggactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaaag tggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctcgcgaag ccaaagtgca gtggaaggtc gataacgctc tgcagagcgg caacagccag      480

gagtctgtga ctgaacagga cagtaaagat tcaacctata gcctgtcaag cacactgact      540

ctgagcaagg cagactacga gaagcacaaa gtgtatgcct gcgaagtcac acatcagggg      600

ctgtcctctc ctgtgactaa gagctttaac agaggagagt gt                         642


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Artificial sequence

<400>  12

Gln Asp Val Ser Ile Gly 
1               5       


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  13

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  14
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  14

Ser Ala Ser 
1           


<210>  15
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  15

Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln Met Thr Gln Ser Pro 
1               5                   10                  15      


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            20                  25                  30          


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
    50                  55                  60                  


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Arg Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220         


<210>  16
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  16
gactacaaag acgacgatga caaagatatc cagatgaccc agtcccctag ctccctgtcc       60

gcttctgtgg gcgatagggt cactattacc tgccgcgcat ctcaggacgt gaacaccgca      120

gtcgcctggt accagcagaa gcctgggaaa gctccaaagc tgctgatcta cagtgcatca      180

ttcctgtatt caggagtgcc cagccggttt agcggcagca gatctggcac cgatttcaca      240

ctgactattt ctagtctgca gcctgaggac tttgccacat actattgcca gcagcactat      300

accacacccc ctactttcgg ccaggggacc aaagtggaga tcaagcgaac tgtggccgct      360

ccaagtgtct tcatttttcc acccagcgat gaaagactga agtccggcac agcttctgtg      420

gtctgtctgc tgaacaattt ttaccccaga gaggccaaag tgcagtggaa ggtcgacaac      480

gctctgcaga gtggcaacag ccaggagagc gtgacagaac aggattccaa agactctact      540

tatagtctgt caagcaccct gacactgagc aaggcagact acgaaaagca taaagtgtat      600

gcctgtgagg tcacacatca ggggctgtca tcaccagtca ccaaatcatt caatcggggg      660

gagtgc                                                                 666


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  18

Asp Tyr Lys Asp Asp Asp Asp Lys Asp Ile Gln Met Thr Gln Ser Pro 
1               5                   10                  15      


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
            20                  25                  30          


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        35                  40                  45              


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
    50                  55                  60                  


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
            100                 105                 110         


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
        115                 120                 125             


Ser Asp Glu Arg Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
    130                 135                 140                 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
145                 150                 155                 160 


Ala Leu Gln Ser Gly Asn Ser Lys Glu Ser Val Thr Glu Gln Asp Ser 
                165                 170                 175     


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Arg Leu Thr Leu Ser Lys Ala 
            180                 185                 190         


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
        195                 200                 205             


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220         


<210>  19
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  19
gactacaaag acgacgatga caaagatatc cagatgaccc agtcccctag ctccctgtcc       60

gcttctgtgg gcgatagggt cactattacc tgccgcgcat ctcaggacgt gaacaccgca      120

gtcgcctggt accagcagaa gcctgggaaa gctccaaagc tgctgatcta cagtgcatca      180

ttcctgtatt caggagtgcc cagccggttt agcggcagca gatctggcac cgatttcaca      240

ctgactattt ctagtctgca gcctgaggac tttgccacat actattgcca gcagcactat      300

accacacccc ctactttcgg ccaggggacc aaagtggaga tcaagcgaac tgtggccgct      360

ccaagtgtct tcatttttcc acccagcgat gaaagactga agtccggcac agcttctgtg      420

gtctgtctgc tgaacaattt ttaccccaga gaggccaaag tgcagtggaa ggtcgacaac      480

gctctgcaga gtggcaacag caaggagagc gtgacagaac aggattccaa agactctact      540

tatagtctgt caagcagact gacactgagc aaggcagact acgaaaagca taaagtgtat      600

gcctgtgagg tcacacatca ggggctgtca tcaccagtca ccaaatcatt caatcggggg      660

gagtgc                                                                 666


<210>  20
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  21

Gln Asp Val Asn Thr Ala 
1               5       


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  22

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  23

Ser Ala Ser 
1           


<210>  24
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  25
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  25
gatattcaga tgacccagtc cccaagctcc ctgagtgcct cagtgggcga ccgagtcacc       60

atcacatgca aggcttccca ggatgtgtct attggagtcg catggtacca gcagaagcca      120

ggcaaagcac ccaagctgct gatctatagc gcctcctacc ggtataccgg cgtgccctct      180

agattctctg gcagtgggtc aggaacagac tttactctga ccatctctag tctgcagcct      240

gaggatttcg ctacctacta ttgccagcag tactatatct acccagccac ctttggccag      300

gggacaaaag tggagatcaa gaggactgtg gccgctccct ccgtcttcat ttttccccct      360

tctgacgaac agctgaaaag tggcacagcc agcgtggtct gtctgctgaa caatttctac      420

cctcgcgaag ccaaagtgca gtggaaggtc gataacgctc tgcagagcgg caacagccag      480

gagtctgtga ctgaacagga cagtaaagat tcaacctata gcctgtcaag cacactgact      540

ctgagcaagg cagactacga gaagcacaaa gtgtatgcct gcgaagtcac acatcagggg      600

ctgtcctctc ctgtgactaa gagctttaac agaggagagt gt                         642


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  26

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Ala 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  27

Gln Asp Val Ser Ile Gly 
1               5       


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  28

Gln Gln Tyr Tyr Ile Tyr Pro Ala Thr 
1               5                   


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  29

Ser Ala Ser 
1           


<210>  30
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Glu Val Thr Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly 
    


<210>  31
<211>  1347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  31
gaggtgcagc tggtcgaaag cggaggagga ctggtgcagc caggagggtc actgcgactg       60

agctgcgcag cttccggctt caacatcaag gacacctaca ttcactgggt ccgccaggct      120

cctggaaaag gcctggagtg ggtggcacga atctatccaa ctaatggata cacccggtat      180

gccgactccg tgaagggccg gttcaccatt tctgcagata caagtaaaaa cactgcctac      240

ctgcagatga acagcctgcg agccgaagat acagccgtgt actattgcag ccgatgggga      300

ggcgacggct tctacgctat ggattattgg gggcagggaa ccctggtcac agtgagctcc      360

gcatcaacaa aggggcctag cgtgtttcca ctggccccct ctagtaaatc cacctctggg      420

ggaacagcag ccctgggatg tgaggtgacc gactacttcc cagagcccgt cactgtgagc      480

tggaactccg gcgccctgac atctggggtc catacttttc ctgctgtgct gcagtcaagc      540

ggcctgtaca gcctgtcctc tgtggtcact gtgccaagtt caagcctggg gactcagacc      600

tatatctgca acgtgaatca caagccatcc aataccaaag tcgacaagaa agtggaaccc      660

aagtcttgtg ataaaacaca tacttgcccc ccttgtcctg caccagagct gctgggagga      720

ccaagcgtgt tcctgtttcc acccaagcct aaagacaccc tgatgattag taggactcca      780

gaagtcacct gcgtggtcgt ggacgtgagc cacgaggacc ccgaagtcaa gttcaactgg      840

tacgtggatg gcgtcgaggt gcataatgcc aagacaaaac ccagggagga acagtacaac      900

tccacttatc gcgtcgtgtc tgtcctgacc gtgctgcacc aggactggct gaacggcaag      960

gagtataagt gcaaagtgag caataaggct ctgcccgcac ctatcgagaa aacaatttcc     1020

aaggctaaag ggcagcctag agaaccacag gtgtacgtgt accctccatc tagggacgag     1080

ctgaccaaga accaggtcag tctgacatgt ctggtgaaag ggttctatcc cagcgatatc     1140

gcagtggagt gggaatccaa tggacagcct gagaacaatt acaagaccac accccctgtg     1200

ctggactctg atggaagttt cgccctggtg agtaagctga ccgtcgataa atcacggtgg     1260

cagcagggca acgtgttcag ctgttcagtg atgcacgaag cactgcacaa ccactacacc     1320

cagaaaagcc tgtccctgtc ccccggc                                         1347


<210>  32
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  33

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  34
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  34

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  35

Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               


<210>  36
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  37
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  37
gaggtgcagc tggtggaatc aggagggggc ctggtgcagc ccggagggtc tctgcgactg       60

tcatgtgccg cttctgggtt cactttcgca gactacacaa tggattgggt gcgacaggcc      120

cccggaaagg gactggagtg ggtgggcgat gtcaacccta attctggcgg gagtatctac      180

aaccagcggt tcaaggggag attcactttt tcagtggaca gaagcaaaaa caccctgtat      240

ctgcagatga acagcctgag ggccgaagat accgctgtct actattgcgc tcgcaatctg      300

ggccccagtt tctactttga ctattggggg cagggaaccc tggtgacagt cagctccgct      360

agcactaagg ggccttccgt gtttccactg gctccctcta gtaaatccac ctctggaggc      420

acagctgcac tgggatgtct ggtgaaggat tacttccctg aaccagtcac agtgagttgg      480

aactcagggg ctctgacaag tggagtccat acttttcccg cagtgctgca gtcaagcgga      540

ctgtactccc tgtcctctgt ggtcaccgtg cctagttcaa gcctgggcac ccagacatat      600

atctgcaacg tgaatcacaa gccatcaaat acaaaagtcg acaagaaagt ggagcccaag      660

agctgtgata aaactcatac ctgcccacct tgtccggcgc cagaactgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gacaccctga tgatttcccg gactcctgag      780

gtcacctgcg tggtcgtgga cgtgtctcac gaggaccccg aagtcaagtt caactggtac      840

gtggatggcg tcgaagtgca taatgccaag accaaacccc gggaggaaca gtacaactct      900

acctatagag tcgtgagtgt cctgacagtg ctgcaccagg actggctgaa tgggaaggag      960

tataagtgta aagtgagcaa caaagccctg cccgccccaa tcgaaaaaac aatctctaaa     1020

gcaaaaggac agcctcgcga accacaggtc tacgtctacc ccccatcaag agatgaactg     1080

acaaaaaatc aggtctctct gacatgcctg gtcaaaggat tctacccttc cgacatcgcc     1140

gtggagtggg aaagtaacgg ccagcccgag aacaattaca agaccacacc ccctgtcctg     1200

gactctgatg ggagtttcgc tctggtgtca aagctgaccg tcgataaaag ccggtggcag     1260

cagggcaatg tgtttagctg ctccgtcatg cacgaagccc tgcacaatca ctacacacag     1320

aagtccctga gcctgagccc tggc                                            1344


<210>  38
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  39
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  39

Gly Phe Thr Phe Ala Asp Tyr Thr 
1               5               


<210>  40
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  40

Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  41

Val Asn Pro Asn Ser Gly Gly Ser 
1               5               


<210>  42
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifcial sequence

<400>  42

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Thr Gly Ser Asp Ile Gln Met 
1               5                   10                  15      


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
            20                  25                  30          


Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly Val Ala Trp Tyr 
        35                  40                  45              


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser 
    50                  55                  60                  


Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
65                  70                  75                  80  


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
                85                  90                  95      


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr Phe Gly Gln 
            100                 105                 110         


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
        115                 120                 125             


Ile Phe Pro Pro Ser Asp Glu Glu Leu Lys Ser Gly Thr Ala Ser Val 
    130                 135                 140                 


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
145                 150                 155                 160 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Glu Glu Ser Val Thr 
                165                 170                 175     


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Glu 
            180                 185                 190         


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
        195                 200                 205             


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
    210                 215                 220                 


Glu Cys 
225     


<210>  43
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  43
tatccctacg atgtgcctga ctacgctact ggctccgata tccagatgac ccagtctcca       60

agctccctga gtgcatcagt gggggaccga gtcaccatca catgcaaggc ttcccaggat      120

gtgtctattg gagtcgcatg gtaccagcag aagccaggca aagcacccaa gctgctgatc      180

tacagcgcct cctaccggta tactggggtg ccttccagat tctctggcag tgggtcagga      240

accgacttta ctctgaccat ctctagtctg cagcccgagg atttcgccac ctactattgc      300

cagcagtact atatctaccc ttataccttt ggccagggga caaaagtgga gatcaagagg      360

acagtggccg ctccaagtgt cttcattttt cccccttccg acgaagagct gaaaagtgga      420

actgcttcag tggtctgtct gctgaacaat ttctaccccc gcgaagccaa agtgcagtgg      480

aaggtcgata acgctctgca gagcggcaat tccgaggagt ctgtgacaga acaggacagt      540

aaagattcaa cttatagcct gtcaagcaca ctggagctgt ctaaggcaga ctacgagaag      600

cacaaagtgt atgcctgcga agtcacccat caggggctgt cctctcccgt gacaaagagc      660

tttaacagag gagagtgt                                                    678


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  45

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Glu Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  46
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  46
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacgttaac accgctgtag cttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatcctttt tgtacagtgg ggtcccatca      180

aggttcagtg gcagtcgatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag cattacacta ccccacccac tttcggccaa      300

gggaccaaag tggagatcaa aggtggttct ggtggtggtt ctggtggtgg ttctggtggt      360

ggttctggtg gtggttctgg tgaagtgcag ctggtggagt ctgggggagg cttggtacag      420

cctggcgggt ccctgagact ctcctgtgca gcctctggat tcaacattaa agatacttat      480

atccactggg tccggcaagc tccagggaag ggcctggagt gggtcgcacg tatttatccc      540

acaaatggtt acacacggta tgcggactct gtgaagggcc gattcaccat ctccgcagac      600

acttccaaga acaccgcgta tctgcaaatg aacagtctga gagctgagga cacggccgtt      660

tattactgtt caagatgggg cggagacggt ttctacgcta tggactactg gggccaaggg      720

accctggtca ccgtctcctc agccgccgag cccaagagca gcgataagac ccacacctgc      780

cctccctgtc cagctccaga actgctggga ggacctagcg tgttcctgtt tccccctaag      840

ccaaaagaca ctctgatgat ttccaggact cccgaggtga cctgcgtggt ggtggacgtg      900

tctcacgagg accccgaagt gaagttcaac tggtacgtgg atggcgtgga agtgcataat      960

gctaagacaa aaccaagaga ggaacagtac aactccactt atcgcgtcgt gagcgtgctg     1020

accgtgctgc accaggactg gctgaacggg aaggagtata agtgcaaagt cagtaataag     1080

gccctgcctg ctccaatcga aaaaaccatc tctaaggcca aaggccagcc aagggagccc     1140

caggtgtaca catacccacc cagcagagac gaactgacca agaaccaggt gtccctgaca     1200

tgtctggtga aaggcttcta tcctagtgat attgctgtgg agtgggaatc aaatggacag     1260

ccagagaaca attacaagac cacacctcca gtgctggacg aggatggcag cttcgccctg     1320

gtgtccaagc tgacagtgga taaatctcga tggcagcagg ggaacgtgtt tagttgttca     1380

gtgatgcatg aagccctgca caatcattac actcagaaga gcctgtccct gtctcccggc     1440

aaa                                                                   1443


<210>  47
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  48
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ile 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Arg Tyr Met Thr Trp Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  50
<211>  1443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  50
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacgttaac accgctgtag cttggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctattct gcatcctttt tgtacagtgg ggtcccatca      180

aggttcagtg gcagtcgatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag cattacacta ccccacccac tttcggccaa      300

gggaccaaag tggagatcaa aggtggttct ggtggtggtt ctggtggtgg ttctggtggt      360

ggttctggtg gtggttctgg tgaagtgcag ctggtggagt ctgggggagg cttggtacag      420

cctggcgggt ccctgagact ctcctgtgca gcctctggat tcaacattaa agatacttat      480

atccactggg tccggcaagc tccagggaag ggcctggagt gggtcgcacg tatttatccc      540

acaaatggtt acacacggta tgcggactct gtgaagggcc gattcaccat ctccgcagac      600

acttccaaga acaccgcgta tctgcaaatg aacagtctga gagctgagga cacggccgtt      660

tattactgtt caagatgggg cggagacggt ttctacgcta tggactactg gggccaaggg      720

accctggtca ccgtctcctc agccgccgag cccaagagca gcgataagac ccacacctgc      780

cctccctgtc cagctccaga actgctggga ggacctagcg tgttcctgtt tccccctaag      840

ccaaaagaca ctctgatgat ttccaggact cccgaggtga cctgcgtggt ggtggacgtg      900

tctcacgagg accccgaagt gaagttcaac tggtacgtgg atggcgtgga agtgcataat      960

gctaagacaa aaccaagaga ggaacagtac aactccactt atcgcgtcgt gagcgtgctg     1020

accgtgctgc accaggactg gctgaacggg aaggagtata agtgcaaagt cagtaataag     1080

gccctgcctg ctccaatcga aaaaaccatc tctaaggcca aaggccagcc aagggagccc     1140

caggtgtaca cactgccacc cagcagagac gaactgacca agaaccaggt gtccctgatc     1200

tgtctggtga aaggcttcta tcctagtgat attgctgtgg agtgggaatc aaatggacag     1260

ccagagaaca gatacatgac ctggcctcca gtgctggaca gcgatggcag cttcttcctg     1320

tattccaagc tgacagtgga taaatctcga tggcagcagg ggaacgtgtt tagttgttca     1380

gtgatgcatg aagccctgca caatcattac actcagaaga gcctgtccct gtctcccggc     1440

aaa                                                                   1443


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  53

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  54
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  54
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaaggac tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgca gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac atgcccccct tgtcctgcac cagagctgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gatacactga tgattagtag gaccccagaa      780

gtcacatgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      840

gtggacggcg tcgaggtgca taatgccaag actaaaccca gggaggaaca gtacaacagt      900

acctatcgcg tcgtgtcagt cctgacagtg ctgcatcagg attggctgaa cgggaaagag      960

tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac aatttccaag     1020

gcaaaaggac agcctagaga accacaggtg tacgtgctgc ctccatcaag ggatgagctg     1080

acaaagaacc aggtcagcct gctgtgtctg gtgaaaggat tctatccctc tgacattgct     1140

gtggagtggg aaagtaatgg ccagcctgag aacaattacc tgacctggcc ccctgtgctg     1200

gactcagatg gcagcttctt tctgtatagc aagctgaccg tcgacaaatc ccggtggcag     1260

caggggaatg tgtttagttg ttcagtcatg cacgaggcac tgcacaacca ttacacccag     1320

aagtcactgt cactgtcacc aggg                                            1344


<210>  55
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  55

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  56
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
            340                 345                 350         


Tyr Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Ala Leu Val Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  57
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  57
gaagtgcagc tggtcgaatc tggaggagga ctggtgcagc caggagggtc cctgcgcctg       60

tcttgcgccg ctagtggctt cacttttacc gactacacca tggattgggt gcgacaggca      120

cctggaaagg gcctggagtg ggtcgccgat gtgaacccaa atagcggagg ctccatctac      180

aaccagcggt tcaagggccg gttcaccctg tcagtggacc ggagcaaaaa caccctgtat      240

ctgcagatga atagcctgcg agccgaagat actgctgtgt actattgcgc ccggaatctg      300

gggccctcct tctactttga ctattggggg cagggaactc tggtcaccgt gagctccgcc      360

tccaccaagg gaccttctgt gttcccactg gctccctcta gtaaatccac atctggggga      420

actgcagccc tgggctgtct ggtgaaggac tacttcccag agcccgtcac agtgtcttgg      480

aacagtggcg ctctgacttc tggggtccac acctttcctg cagtgctgca gtcaagcggg      540

ctgtacagcc tgtcctctgt ggtcaccgtg ccaagttcaa gcctgggaac acagacttat      600

atctgcaacg tgaatcacaa gccatccaat acaaaagtcg acaagaaagt ggaacccaag      660

tcttgtgata aaacccatac atgcccccct tgtcctgcac cagagctgct gggaggacca      720

agcgtgttcc tgtttccacc caagcctaaa gatacactga tgattagtag gaccccagaa      780

gtcacatgcg tggtcgtgga cgtgagccac gaggaccccg aagtcaagtt taactggtac      840

gtggacggcg tcgaggtgca taatgccaag actaaaccca gggaggaaca gtacaacagt      900

acctatcgcg tcgtgtcagt cctgacagtg ctgcatcagg attggctgaa cgggaaagag      960

tataagtgca aagtgagcaa taaggctctg cccgcaccta tcgagaaaac aatttccaag     1020

gcaaaaggac agcctagaga accacaggtg tacgtgtatc ctccatcaag ggatgagctg     1080

acaaagaacc aggtcagcct gacttgtctg gtgaaaggat tctatccctc tgacattgct     1140

gtggagtggg aaagtaatgg ccagcctgag aacaattaca agaccacacc ccctgtgctg     1200

gactcagatg gcagcttcgc gctggtgagc aagctgaccg tcgacaaatc ccggtggcag     1260

caggggaatg tgtttagttg ttcagtcatg cacgaggcac tgcacaacca ttacacccag     1320

aagtcactgt cactgtcacc aggg                                            1344


<210>  58
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  59
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  59

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Thr Met Asp Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Val Asn Pro Asn 
                165                 170                 175     


Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe Lys Gly Arg Phe Thr Leu 
            180                 185                 190         


Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Gly Pro 
    210                 215                 220                 


Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Ala Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  60
<211>  1425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  60
gacattcaga tgacccagag ccctagctcc ctgagtgcct cagtcgggga cagggtgact       60

atcacctgca aggcttcaca ggatgtcagc attggcgtgg catggtacca gcagaagcca      120

gggaaagcac ccaagctgct gatctatagc gcctcctaca ggtatacagg cgtgccatcc      180

cgcttctctg gcagtgggtc aggaactgac tttacactga ctatttctag tctgcagccc      240

gaagatttcg ccacatacta ttgccagcag tactatatct acccttatac ttttggccag      300

gggaccaaag tggagattaa gggcggagga ggctccggag gaggagggtc tggaggagga      360

ggaagtgagg tccagctggt ggaatctgga ggaggactgg tgcagccagg agggtccctg      420

aggctgtctt gtgccgctag tggcttcacc tttacagact acacaatgga ttgggtgcgc      480

caggcaccag gaaagggact ggaatgggtc gctgatgtga accctaatag cggaggctcc      540

atctacaacc agcggttcaa aggacggttc accctgtcag tggaccggag caagaacacc      600

ctgtatctgc agatgaacag cctgagagcc gaggatactg ctgtgtacta ttgcgccagg      660

aatctgggcc caagcttcta ctttgactat tgggggcagg gaacactggt cactgtgtca      720

agcgcagccg aacccaaatc ctctgataag actcacacct gcccaccttg tccagctcca      780

gagctgctgg gaggacctag cgtgttcctg tttccaccca agccaaaaga cactctgatg      840

atttctagaa cccctgaagt gacatgtgtg gtcgtggacg tcagtcacga ggaccccgaa      900

gtcaaattca actggtacgt ggatggcgtc gaggtgcata atgccaagac caaaccccga      960

gaggaacagt acaactcaac ctatcgggtc gtgagcgtcc tgacagtgct gcatcaggac     1020

tggctgaacg gcaaggagta taagtgcaaa gtgagcaaca aggctctgcc tgcaccaatc     1080

gagaagacca tttccaaggc taaagggcag ccccgcgaac ctcaggtcta cgtgtatcct     1140

ccaagccgag atgagctgac aaaaaaccag gtctccctga cttgtctggt gaagggattt     1200

tacccaagtg acatcgcagt ggagtgggaa tcaaatggcc agcccgaaaa caattataag     1260

accacacccc ctgtgctgga ctctgatggg agtttcgcac tggtctccaa actgaccgtg     1320

gacaagtctc ggtggcagca gggaaacgtc tttagctgtt ccgtgatgca cgaggccctg     1380

cacaatcatt acacacagaa atctctgagt ctgtcacctg gcaag                     1425


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Gly 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Thr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Val Asn Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Leu Ser Val Asp Arg Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  63
<211>  480
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr 
145                 150                 155                 160 


Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
                165                 170                 175     


Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
    210                 215                 220                 


Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Val 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Leu 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Leu Thr Trp Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


<210>  64
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  64
gacattcaga tgacacagag ccccagctcc ctgagtgctt cagtcggcga cagggtgact       60

atcacctgcc gcgcatccca ggatgtcaac accgctgtgg catggtacca gcagaagcct      120

ggaaaagccc caaagctgct gatctacagc gcttccttcc tgtattctgg cgtgccaagt      180

cggttttctg gaagtagatc aggcactgac ttcacactga ctatctctag tctgcagccc      240

gaagattttg ccacctacta ttgccagcag cactatacca caccccctac attcggacag      300

ggcactaaag tggagattaa gggcgggtca ggcggaggga gcggaggagg gtccggagga      360

gggtctggag gagggagtgg agaggtccag ctggtggaat ctggaggagg actggtgcag      420

cctggaggct cactgcgact gagctgtgcc gcttccggct ttaacatcaa agacacatac      480

attcattggg tcaggcaggc accagggaag ggactggaat gggtggcccg catctatccc      540

acaaatgggt acactcgata tgccgacagc gtgaaaggac ggtttaccat ttctgctgat      600

accagtaaga acacagcata cctgcagatg aacagcctgc gcgcagagga tacagccgtg      660

tactattgca gtcgatgggg gggagacggc ttctacgcca tggattattg gggccagggg      720

actctggtca ccgtgtcaag cgcagccgaa cctaaatcct ctgacaagac ccacacatgc      780

ccaccctgtc ctgctccaga gctgctggga ggaccatccg tgttcctgtt tcctccaaag      840

cctaaagata cactgatgat tagccgcact cccgaagtca cctgtgtggt cgtggacgtg      900

tcccacgagg accccgaagt caagttcaac tggtacgtgg acggcgtcga ggtgcataat      960

gccaagacta aaccaagaga ggaacagtac aattcaacct atagggtcgt gagcgtcctg     1020

acagtgctgc atcaggattg gctgaacggc aaggagtata agtgcaaagt gtctaacaag     1080

gccctgcccg ctcctatcga gaagactatt agcaaggcaa aagggcagcc acgggaaccc     1140

caggtctacg tgctgccccc tagcagagac gagctgacca aaaaccaggt ctccctgctg     1200

tgtctggtga agggctttta tcctagtgat atcgctgtgg agtgggaatc aaatgggcag     1260

ccagaaaaca attacctgac atggccaccc gtgctggaca gcgatgggtc cttctttctg     1320

tattccaaac tgactgtgga caagtctaga tggcagcagg gaaacgtctt cagctgttcc     1380

gtgatgcacg aggccctgca caatcattac acccagaagt ctctgagtct gtcacccggc     1440


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  67

Gln Asp Val Asn Thr Ala 
1               5       


<210>  68
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  68

Ser Ala Ser 
1           


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  69

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  70

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  71
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  71

Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               


<210>  72
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  72

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              


