                         SEQUENCE LISTING

<110>  Instituto de Medicina Molecular João Lobo Antunes
       Children's Medical Research Institute
 
<120>  Treatment of ALT cancers

<130>  187347PRV

<150>  AU2019901766
<151>  2019-05-24

<150>  GB1907518.3
<151>  2019-05-28

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  1132
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Arg Ala Pro Arg Cys Arg Ala Val Arg Ser Leu Leu Arg Ser 
1               5                   10                  15      


His Tyr Arg Glu Val Leu Pro Leu Ala Thr Phe Val Arg Arg Leu Gly 
            20                  25                  30          


Pro Gln Gly Trp Arg Leu Val Gln Arg Gly Asp Pro Ala Ala Phe Arg 
        35                  40                  45              


Ala Leu Val Ala Gln Cys Leu Val Cys Val Pro Trp Asp Ala Arg Pro 
    50                  55                  60                  


Pro Pro Ala Ala Pro Ser Phe Arg Gln Val Ser Cys Leu Lys Glu Leu 
65                  70                  75                  80  


Val Ala Arg Val Leu Gln Arg Leu Cys Glu Arg Gly Ala Lys Asn Val 
                85                  90                  95      


Leu Ala Phe Gly Phe Ala Leu Leu Asp Gly Ala Arg Gly Gly Pro Pro 
            100                 105                 110         


Glu Ala Phe Thr Thr Ser Val Arg Ser Tyr Leu Pro Asn Thr Val Thr 
        115                 120                 125             


Asp Ala Leu Arg Gly Ser Gly Ala Trp Gly Leu Leu Leu Arg Arg Val 
    130                 135                 140                 


Gly Asp Asp Val Leu Val His Leu Leu Ala Arg Cys Ala Leu Phe Val 
145                 150                 155                 160 


Leu Val Ala Pro Ser Cys Ala Tyr Gln Val Cys Gly Pro Pro Leu Tyr 
                165                 170                 175     


Gln Leu Gly Ala Ala Thr Gln Ala Arg Pro Pro Pro His Ala Ser Gly 
            180                 185                 190         


Pro Arg Arg Arg Leu Gly Cys Glu Arg Ala Trp Asn His Ser Val Arg 
        195                 200                 205             


Glu Ala Gly Val Pro Leu Gly Leu Pro Ala Pro Gly Ala Arg Arg Arg 
    210                 215                 220                 


Gly Gly Ser Ala Ser Arg Ser Leu Pro Leu Pro Lys Arg Pro Arg Arg 
225                 230                 235                 240 


Gly Ala Ala Pro Glu Pro Glu Arg Thr Pro Val Gly Gln Gly Ser Trp 
                245                 250                 255     


Ala His Pro Gly Arg Thr Arg Gly Pro Ser Asp Arg Gly Phe Cys Val 
            260                 265                 270         


Val Ser Pro Ala Arg Pro Ala Glu Glu Ala Thr Ser Leu Glu Gly Ala 
        275                 280                 285             


Leu Ser Gly Thr Arg His Ser His Pro Ser Val Gly Arg Gln His His 
    290                 295                 300                 


Ala Gly Pro Pro Ser Thr Ser Arg Pro Pro Arg Pro Trp Asp Thr Pro 
305                 310                 315                 320 


Cys Pro Pro Val Tyr Ala Glu Thr Lys His Phe Leu Tyr Ser Ser Gly 
                325                 330                 335     


Asp Lys Glu Gln Leu Arg Pro Ser Phe Leu Leu Ser Ser Leu Arg Pro 
            340                 345                 350         


Ser Leu Thr Gly Ala Arg Arg Leu Val Glu Thr Ile Phe Leu Gly Ser 
        355                 360                 365             


Arg Pro Trp Met Pro Gly Thr Pro Arg Arg Leu Pro Arg Leu Pro Gln 
    370                 375                 380                 


Arg Tyr Trp Gln Met Arg Pro Leu Phe Leu Glu Leu Leu Gly Asn His 
385                 390                 395                 400 


Ala Gln Cys Pro Tyr Gly Val Leu Leu Lys Thr His Cys Pro Leu Arg 
                405                 410                 415     


Ala Ala Val Thr Pro Ala Ala Gly Val Cys Ala Arg Glu Lys Pro Gln 
            420                 425                 430         


Gly Ser Val Ala Ala Pro Glu Glu Glu Asp Thr Asp Pro Arg Arg Leu 
        435                 440                 445             


Val Gln Leu Leu Arg Gln His Ser Ser Pro Trp Gln Val Tyr Gly Phe 
    450                 455                 460                 


Val Arg Ala Cys Leu Arg Arg Leu Val Pro Pro Gly Leu Trp Gly Ser 
465                 470                 475                 480 


Arg His Asn Glu Arg Arg Phe Leu Arg Asn Thr Lys Lys Phe Ile Ser 
                485                 490                 495     


Leu Gly Lys His Ala Lys Leu Ser Leu Gln Glu Leu Thr Trp Lys Met 
            500                 505                 510         


Ser Val Arg Asp Cys Ala Trp Leu Arg Arg Ser Pro Gly Val Gly Cys 
        515                 520                 525             


Val Pro Ala Ala Glu His Arg Leu Arg Glu Glu Ile Leu Ala Lys Phe 
    530                 535                 540                 


Leu His Trp Leu Met Ser Val Tyr Val Val Glu Leu Leu Arg Ser Phe 
545                 550                 555                 560 


Phe Tyr Val Thr Glu Thr Thr Phe Gln Lys Asn Arg Leu Phe Phe Tyr 
                565                 570                 575     


Arg Lys Ser Val Trp Ser Lys Leu Gln Ser Ile Gly Ile Arg Gln His 
            580                 585                 590         


Leu Lys Arg Val Gln Leu Arg Glu Leu Ser Glu Ala Glu Val Arg Gln 
        595                 600                 605             


His Arg Glu Ala Arg Pro Ala Leu Leu Thr Ser Arg Leu Arg Phe Ile 
    610                 615                 620                 


Pro Lys Pro Asp Gly Leu Arg Pro Ile Val Asn Met Asp Tyr Val Val 
625                 630                 635                 640 


Gly Ala Arg Thr Phe Arg Arg Glu Lys Arg Ala Glu Arg Leu Thr Ser 
                645                 650                 655     


Arg Val Lys Ala Leu Phe Ser Val Leu Asn Tyr Glu Arg Ala Arg Arg 
            660                 665                 670         


Pro Gly Leu Leu Gly Ala Ser Val Leu Gly Leu Asp Asp Ile His Arg 
        675                 680                 685             


Ala Trp Arg Thr Phe Val Leu Arg Val Arg Ala Gln Asp Pro Pro Pro 
    690                 695                 700                 


Glu Leu Tyr Phe Val Lys Val Asp Val Thr Gly Ala Tyr Asp Thr Ile 
705                 710                 715                 720 


Pro Gln Asp Arg Leu Thr Glu Val Ile Ala Ser Ile Ile Lys Pro Gln 
                725                 730                 735     


Asn Thr Tyr Cys Val Arg Arg Tyr Ala Val Val Gln Lys Ala Ala His 
            740                 745                 750         


Gly His Val Arg Lys Ala Phe Lys Ser His Val Ser Thr Leu Thr Asp 
        755                 760                 765             


Leu Gln Pro Tyr Met Arg Gln Phe Val Ala His Leu Gln Glu Thr Ser 
    770                 775                 780                 


Pro Leu Arg Asp Ala Val Val Ile Glu Gln Ser Ser Ser Leu Asn Glu 
785                 790                 795                 800 


Ala Ser Ser Gly Leu Phe Asp Val Phe Leu Arg Phe Met Cys His His 
                805                 810                 815     


Ala Val Arg Ile Arg Gly Lys Ser Tyr Val Gln Cys Gln Gly Ile Pro 
            820                 825                 830         


Gln Gly Ser Ile Leu Ser Thr Leu Leu Cys Ser Leu Cys Tyr Gly Asp 
        835                 840                 845             


Met Glu Asn Lys Leu Phe Ala Gly Ile Arg Arg Asp Gly Leu Leu Leu 
    850                 855                 860                 


Arg Leu Val Asp Asp Phe Leu Leu Val Thr Pro His Leu Thr His Ala 
865                 870                 875                 880 


Lys Thr Phe Leu Arg Thr Leu Val Arg Gly Val Pro Glu Tyr Gly Cys 
                885                 890                 895     


Val Val Asn Leu Arg Lys Thr Val Val Asn Phe Pro Val Glu Asp Glu 
            900                 905                 910         


Ala Leu Gly Gly Thr Ala Phe Val Gln Met Pro Ala His Gly Leu Phe 
        915                 920                 925             


Pro Trp Cys Gly Leu Leu Leu Asp Thr Arg Thr Leu Glu Val Gln Ser 
    930                 935                 940                 


Asp Tyr Ser Ser Tyr Ala Arg Thr Ser Ile Arg Ala Ser Leu Thr Phe 
945                 950                 955                 960 


Asn Arg Gly Phe Lys Ala Gly Arg Asn Met Arg Arg Lys Leu Phe Gly 
                965                 970                 975     


Val Leu Arg Leu Lys Cys His Ser Leu Phe Leu Asp Leu Gln Val Asn 
            980                 985                 990         


Ser Leu Gln Thr Val Cys Thr Asn  Ile Tyr Lys Ile Leu  Leu Leu Gln 
        995                 1000                 1005             


Ala Tyr  Arg Phe His Ala Cys  Val Leu Gln Leu Pro  Phe His Gln 
    1010                 1015                 1020             


Gln Val  Trp Lys Asn Pro Thr  Phe Phe Leu Arg Val  Ile Ser Asp 
    1025                 1030                 1035             


Thr Ala  Ser Leu Cys Tyr Ser  Ile Leu Lys Ala Lys  Asn Ala Gly 
    1040                 1045                 1050             


Met Ser  Leu Gly Ala Lys Gly  Ala Ala Gly Pro Leu  Pro Ser Glu 
    1055                 1060                 1065             


Ala Val  Gln Trp Leu Cys His  Gln Ala Phe Leu Leu  Lys Leu Thr 
    1070                 1075                 1080             


Arg His  Arg Val Thr Tyr Val  Pro Leu Leu Gly Ser  Leu Arg Thr 
    1085                 1090                 1095             


Ala Gln  Thr Gln Leu Ser Arg  Lys Leu Pro Gly Thr  Thr Leu Thr 
    1100                 1105                 1110             


Ala Leu  Glu Ala Ala Ala Asn  Pro Ala Leu Pro Ser  Asp Phe Lys 
    1115                 1120                 1125             


Thr Ile  Leu Asp 
    1130         


<210>  2
<211>  2048
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  3
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Val Thr Ser Ile Ala Leu Arg Ala Glu Thr Trp Leu Leu Ala 
1               5                   10                  15      


Ala Trp His Val Lys Val Pro Pro Met Trp Leu Glu Ala Cys Ile Asn 
            20                  25                  30          


Trp Ile Gln Glu Glu Asn Asn Asn Val Asn Leu Ser Gln Ala Gln Met 
        35                  40                  45              


Asn Lys Gln Val Phe Glu Gln Trp Leu Leu Thr Asp Leu Arg Asp Leu 
    50                  55                  60                  


Glu His Pro Leu Leu Pro Asp Gly Ile Leu Glu Ile Pro Lys Gly Glu 
65                  70                  75                  80  


Leu Asn Gly Phe Tyr Ala Leu Gln Ile Asn Ser Leu Val Asp Val Ser 
                85                  90                  95      


Gln Pro Ala Tyr Ser Gln Ile Gln Lys Leu Arg Gly Lys Asn Thr Thr 
            100                 105                 110         


Asn Asp Leu Val Thr Ala Glu Ala Gln Val Thr Pro Lys Pro Trp Glu 
        115                 120                 125             


Ala Lys Pro Ser Arg Met Leu Met Leu Gln Leu Thr Asp Gly Ile Val 
    130                 135                 140                 


Gln Ile Gln Gly Met Glu Tyr Gln Pro Ile Pro Ile Leu His Ser Asp 
145                 150                 155                 160 


Leu Pro Pro Gly Thr Lys Ile Leu Ile Tyr Gly Asn Ile Ser Phe Arg 
                165                 170                 175     


Leu Gly Val Leu Leu Leu Lys Pro Glu Asn Val Lys Val Leu Gly Gly 
            180                 185                 190         


Glu Val Asp Ala Leu Leu Glu Glu Tyr Ala Gln Glu Lys Val Leu Ala 
        195                 200                 205             


Arg Leu Ile Gly Glu Pro Asp Leu Val Val Ser Val Ile Pro Asn Asn 
    210                 215                 220                 


Ser Asn Glu Asn Ile Pro Arg Val Thr Asp Val Leu Asp Pro Ala Leu 
225                 230                 235                 240 


Gly Pro Ser Asp Glu Glu Leu Leu Ala Ser Leu Asp Glu Asn Asp Glu 
                245                 250                 255     


Leu Thr Ala Asn Asn Asp Thr Ser Ser Glu Arg Cys Phe Thr Thr Gly 
            260                 265                 270         


Ser Ser Ser Asn Thr Ile Pro Thr Arg Gln Ser Ser Phe Glu Pro Glu 
        275                 280                 285             


Phe Val Ile Ser Pro Arg Pro Lys Glu Glu Pro Ser Asn Leu Ser Ile 
    290                 295                 300                 


His Val Met Asp Gly Glu Leu Asp Asp Phe Ser Leu Glu Glu Ala Leu 
305                 310                 315                 320 


Leu Leu Glu Glu Thr Val Gln Lys Glu Gln Met Glu Thr Lys Glu Leu 
                325                 330                 335     


Gln Pro Leu Thr Phe Asn Arg Asn Ala Asp Arg Ser Ile Glu Arg Phe 
            340                 345                 350         


Ser His Asn Pro Asn Thr Thr Asn Asn Phe Ser Leu Thr Cys Lys Asn 
        355                 360                 365             


Gly Asn Asn Asn Trp Ser Glu Lys Asn Val Ser Glu Gln Met Thr Asn 
    370                 375                 380                 


Glu Asp Lys Ser Phe Gly Cys Pro Ser Val Arg Asp Gln Asn Arg Ser 
385                 390                 395                 400 


Ile Phe Ser Val His Cys Asn Val Pro Leu Ala His Asp Phe Thr Asn 
                405                 410                 415     


Lys Glu Lys Asn Leu Glu Thr Asp Asn Lys Ile Lys Gln Thr Ser Ser 
            420                 425                 430         


Ser Asp Ser His Ser Leu Asn Asn Lys Ile Leu Asn Arg Glu Val Val 
        435                 440                 445             


Asn Tyr Val Gln Lys Arg Asn Ser Gln Ile Ser Asn Glu Asn Asp Cys 
    450                 455                 460                 


Asn Leu Gln Ser Cys Ser Leu Arg Ser Ser Glu Asn Ser Ile Asn Leu 
465                 470                 475                 480 


Ser Ile Ala Met Asp Leu Tyr Ser Pro Pro Phe Val Tyr Leu Ser Val 
                485                 490                 495     


Leu Met Ala Ser Lys Pro Lys Glu Val Thr Thr Val Lys Val Lys Ala 
            500                 505                 510         


Phe Ile Val Thr Leu Thr Gly Asn Leu Ser Ser Ser Gly Gly Ile Trp 
        515                 520                 525             


Ser Ile Thr Ala Lys Val Ser Asp Gly Thr Ala Tyr Leu Asp Val Asp 
    530                 535                 540                 


Phe Val Asp Glu Ile Leu Thr Ser Leu Ile Gly Phe Ser Val Pro Glu 
545                 550                 555                 560 


Met Lys Gln Ser Lys Lys Asp Pro Leu Gln Tyr Gln Lys Phe Leu Glu 
                565                 570                 575     


Gly Leu Gln Lys Cys Gln Arg Asp Leu Ile Asp Leu Cys Cys Leu Met 
            580                 585                 590         


Thr Ile Ser Phe Asn Pro Ser Leu Ser Lys Ala Met Val Leu Ala Leu 
        595                 600                 605             


Gln Asp Val Asn Met Glu His Leu Glu Asn Leu Lys Lys Arg Leu Asn 
    610                 615                 620                 


Lys 
625 


<210>  4
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Ala Ala Asp Ser Phe Ser Gly Gly Pro Ala Gly Val Arg 
1               5                   10                  15      


Leu Pro Arg Ser Pro Pro Leu Lys Val Leu Ala Glu Gln Leu Arg Arg 
            20                  25                  30          


Asp Ala Glu Gly Gly Pro Gly Ala Trp Arg Leu Ser Arg Ala Ala Ala 
        35                  40                  45              


Gly Arg Gly Pro Leu Asp Leu Ala Ala Val Trp Met Gln Gly Arg Val 
    50                  55                  60                  


Val Met Ala Asp Arg Gly Glu Ala Arg Leu Arg Asp Pro Ser Gly Asp 
65                  70                  75                  80  


Phe Ser Val Arg Gly Leu Glu Arg Val Pro Arg Gly Arg Pro Cys Leu 
                85                  90                  95      


Val Pro Gly Lys Tyr Val Met Val Met Gly Val Val Gln Ala Cys Ser 
            100                 105                 110         


Pro Glu Pro Cys Leu Gln Ala Val Lys Met Thr Asp Leu Ser Asp Asn 
        115                 120                 125             


Pro Ile His Glu Ser Met Trp Glu Leu Glu Val Glu Asp Leu His Arg 
    130                 135                 140                 


Asn Ile Pro 
145         


<210>  5
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Asp Ile Phe Asp Cys Ser Arg Asp Leu Phe Ser Val Thr Phe Asp 
1               5                   10                  15      


Leu Gly Phe Cys Ser Pro Asp Ser Asp Asp Glu Ile Leu Glu His Thr 
            20                  25                  30          


Ser Asp 
        


<210>  6
<211>  1417
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Val Pro Gln Asn Asn Leu Gln Glu Gln Leu Glu Arg His 
1               5                   10                  15      


Ser Ala Arg Thr Leu Asn Asn Lys Leu Ser Leu Ser Lys Pro Lys Phe 
            20                  25                  30          


Ser Gly Phe Thr Phe Lys Lys Lys Thr Ser Ser Asp Asn Asn Val Ser 
        35                  40                  45              


Val Thr Asn Val Ser Val Ala Lys Thr Pro Val Leu Arg Asn Lys Asp 
    50                  55                  60                  


Val Asn Val Thr Glu Asp Phe Ser Phe Ser Glu Pro Leu Pro Asn Thr 
65                  70                  75                  80  


Thr Asn Gln Gln Arg Val Lys Asp Phe Phe Lys Asn Ala Pro Ala Gly 
                85                  90                  95      


Gln Glu Thr Gln Arg Gly Gly Ser Lys Ser Leu Leu Pro Asp Phe Leu 
            100                 105                 110         


Gln Thr Pro Lys Glu Val Val Cys Thr Thr Gln Asn Thr Pro Thr Val 
        115                 120                 125             


Lys Lys Ser Arg Asp Thr Ala Leu Lys Lys Leu Glu Phe Ser Ser Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ser Thr Ile Asn Asp Trp Asp Asp Met Asp Asp Phe 
145                 150                 155                 160 


Asp Thr Ser Glu Thr Ser Lys Ser Phe Val Thr Pro Pro Gln Ser His 
                165                 170                 175     


Phe Val Arg Val Ser Thr Ala Gln Lys Ser Lys Lys Gly Lys Arg Asn 
            180                 185                 190         


Phe Phe Lys Ala Gln Leu Tyr Thr Thr Asn Thr Val Lys Thr Asp Leu 
        195                 200                 205             


Pro Pro Pro Ser Ser Glu Ser Glu Gln Ile Asp Leu Thr Glu Glu Gln 
    210                 215                 220                 


Lys Asp Asp Ser Glu Trp Leu Ser Ser Asp Val Ile Cys Ile Asp Asp 
225                 230                 235                 240 


Gly Pro Ile Ala Glu Val His Ile Asn Glu Asp Ala Gln Glu Ser Asp 
                245                 250                 255     


Ser Leu Lys Thr His Leu Glu Asp Glu Arg Asp Asn Ser Glu Lys Lys 
            260                 265                 270         


Lys Asn Leu Glu Glu Ala Glu Leu His Ser Thr Glu Lys Val Pro Cys 
        275                 280                 285             


Ile Glu Phe Asp Asp Asp Asp Tyr Asp Thr Asp Phe Val Pro Pro Ser 
    290                 295                 300                 


Pro Glu Glu Ile Ile Ser Ala Ser Ser Ser Ser Ser Lys Cys Leu Ser 
305                 310                 315                 320 


Thr Leu Lys Asp Leu Asp Thr Ser Asp Arg Lys Glu Asp Val Leu Ser 
                325                 330                 335     


Thr Ser Lys Asp Leu Leu Ser Lys Pro Glu Lys Met Ser Met Gln Glu 
            340                 345                 350         


Leu Asn Pro Glu Thr Ser Thr Asp Cys Asp Ala Arg Gln Ile Ser Leu 
        355                 360                 365             


Gln Gln Gln Leu Ile His Val Met Glu His Ile Cys Lys Leu Ile Asp 
    370                 375                 380                 


Thr Ile Pro Asp Asp Lys Leu Lys Leu Leu Asp Cys Gly Asn Glu Leu 
385                 390                 395                 400 


Leu Gln Gln Arg Asn Ile Arg Arg Lys Leu Leu Thr Glu Val Asp Phe 
                405                 410                 415     


Asn Lys Ser Asp Ala Ser Leu Leu Gly Ser Leu Trp Arg Tyr Arg Pro 
            420                 425                 430         


Asp Ser Leu Asp Gly Pro Met Glu Gly Asp Ser Cys Pro Thr Gly Asn 
        435                 440                 445             


Ser Met Lys Glu Leu Asn Phe Ser His Leu Pro Ser Asn Ser Val Ser 
    450                 455                 460                 


Pro Gly Asp Cys Leu Leu Thr Thr Thr Leu Gly Lys Thr Gly Phe Ser 
465                 470                 475                 480 


Ala Thr Arg Lys Asn Leu Phe Glu Arg Pro Leu Phe Asn Thr His Leu 
                485                 490                 495     


Gln Lys Ser Phe Val Ser Ser Asn Trp Ala Glu Thr Pro Arg Leu Gly 
            500                 505                 510         


Lys Lys Asn Glu Ser Ser Tyr Phe Pro Gly Asn Val Leu Thr Ser Thr 
        515                 520                 525             


Ala Val Lys Asp Gln Asn Lys His Thr Ala Ser Ile Asn Asp Leu Glu 
    530                 535                 540                 


Arg Glu Thr Gln Pro Ser Tyr Asp Ile Asp Asn Phe Asp Ile Asp Asp 
545                 550                 555                 560 


Phe Asp Asp Asp Asp Asp Trp Glu Asp Ile Met His Asn Leu Ala Ala 
                565                 570                 575     


Ser Lys Ser Ser Thr Ala Ala Tyr Gln Pro Ile Lys Glu Gly Arg Pro 
            580                 585                 590         


Ile Lys Ser Val Ser Glu Arg Leu Ser Ser Ala Lys Thr Asp Cys Leu 
        595                 600                 605             


Pro Val Ser Ser Thr Ala Gln Asn Ile Asn Phe Ser Glu Ser Ile Gln 
    610                 615                 620                 


Asn Tyr Thr Asp Lys Ser Ala Gln Asn Leu Ala Ser Arg Asn Leu Lys 
625                 630                 635                 640 


His Glu Arg Phe Gln Ser Leu Ser Phe Pro His Thr Lys Glu Met Met 
                645                 650                 655     


Lys Ile Phe His Lys Lys Phe Gly Leu His Asn Phe Arg Thr Asn Gln 
            660                 665                 670         


Leu Glu Ala Ile Asn Ala Ala Leu Leu Gly Glu Asp Cys Phe Ile Leu 
        675                 680                 685             


Met Pro Thr Gly Gly Gly Lys Ser Leu Cys Tyr Gln Leu Pro Ala Cys 
    690                 695                 700                 


Val Ser Pro Gly Val Thr Val Val Ile Ser Pro Leu Arg Ser Leu Ile 
705                 710                 715                 720 


Val Asp Gln Val Gln Lys Leu Thr Ser Leu Asp Ile Pro Ala Thr Tyr 
                725                 730                 735     


Leu Thr Gly Asp Lys Thr Asp Ser Glu Ala Thr Asn Ile Tyr Leu Gln 
            740                 745                 750         


Leu Ser Lys Lys Asp Pro Ile Ile Lys Leu Leu Tyr Val Thr Pro Glu 
        755                 760                 765             


Lys Ile Cys Ala Ser Asn Arg Leu Ile Ser Thr Leu Glu Asn Leu Tyr 
    770                 775                 780                 


Glu Arg Lys Leu Leu Ala Arg Phe Val Ile Asp Glu Ala His Cys Val 
785                 790                 795                 800 


Ser Gln Trp Gly His Asp Phe Arg Gln Asp Tyr Lys Arg Met Asn Met 
                805                 810                 815     


Leu Arg Gln Lys Phe Pro Ser Val Pro Val Met Ala Leu Thr Ala Thr 
            820                 825                 830         


Ala Asn Pro Arg Val Gln Lys Asp Ile Leu Thr Gln Leu Lys Ile Leu 
        835                 840                 845             


Arg Pro Gln Val Phe Ser Met Ser Phe Asn Arg His Asn Leu Lys Tyr 
    850                 855                 860                 


Tyr Val Leu Pro Lys Lys Pro Lys Lys Val Ala Phe Asp Cys Leu Glu 
865                 870                 875                 880 


Trp Ile Arg Lys His His Pro Tyr Asp Ser Gly Ile Ile Tyr Cys Leu 
                885                 890                 895     


Ser Arg Arg Glu Cys Asp Thr Met Ala Asp Thr Leu Gln Arg Asp Gly 
            900                 905                 910         


Leu Ala Ala Leu Ala Tyr His Ala Gly Leu Ser Asp Ser Ala Arg Asp 
        915                 920                 925             


Glu Val Gln Gln Lys Trp Ile Asn Gln Asp Gly Cys Gln Val Ile Cys 
    930                 935                 940                 


Ala Thr Ile Ala Phe Gly Met Gly Ile Asp Lys Pro Asp Val Arg Phe 
945                 950                 955                 960 


Val Ile His Ala Ser Leu Pro Lys Ser Val Glu Gly Tyr Tyr Gln Glu 
                965                 970                 975     


Ser Gly Arg Ala Gly Arg Asp Gly Glu Ile Ser His Cys Leu Leu Phe 
            980                 985                 990         


Tyr Thr Tyr His Asp Val Thr Arg  Leu Lys Arg Leu Ile  Met Met Glu 
        995                 1000                 1005             


Lys Asp  Gly Asn His His Thr  Arg Glu Thr His Phe  Asn Asn Leu 
    1010                 1015                 1020             


Tyr Ser  Met Val His Tyr Cys  Glu Asn Ile Thr Glu  Cys Arg Arg 
    1025                 1030                 1035             


Ile Gln  Leu Leu Ala Tyr Phe  Gly Glu Asn Gly Phe  Asn Pro Asp 
    1040                 1045                 1050             


Phe Cys  Lys Lys His Pro Asp  Val Ser Cys Asp Asn  Cys Cys Lys 
    1055                 1060                 1065             


Thr Lys  Asp Tyr Lys Thr Arg  Asp Val Thr Asp Asp  Val Lys Ser 
    1070                 1075                 1080             


Ile Val  Arg Phe Val Gln Glu  His Ser Ser Ser Gln  Gly Met Arg 
    1085                 1090                 1095             


Asn Ile  Lys His Val Gly Pro  Ser Gly Arg Phe Thr  Met Asn Met 
    1100                 1105                 1110             


Leu Val  Asp Ile Phe Leu Gly  Ser Lys Ser Ala Lys  Ile Gln Ser 
    1115                 1120                 1125             


Gly Ile  Phe Gly Lys Gly Ser  Ala Tyr Ser Arg His  Asn Ala Glu 
    1130                 1135                 1140             


Arg Leu  Phe Lys Lys Leu Ile  Leu Asp Lys Ile Leu  Asp Glu Asp 
    1145                 1150                 1155             


Leu Tyr  Ile Asn Ala Asn Asp  Gln Ala Ile Ala Tyr  Val Met Leu 
    1160                 1165                 1170             


Gly Asn  Lys Ala Gln Thr Val  Leu Asn Gly Asn Leu  Lys Val Asp 
    1175                 1180                 1185             


Phe Met  Glu Thr Glu Asn Ser  Ser Ser Val Lys Lys  Gln Lys Ala 
    1190                 1195                 1200             


Leu Val  Ala Lys Val Ser Gln  Arg Glu Glu Met Val  Lys Lys Cys 
    1205                 1210                 1215             


Leu Gly  Glu Leu Thr Glu Val  Cys Lys Ser Leu Gly  Lys Val Phe 
    1220                 1225                 1230             


Gly Val  His Tyr Phe Asn Ile  Phe Asn Thr Val Thr  Leu Lys Lys 
    1235                 1240                 1245             


Leu Ala  Glu Ser Leu Ser Ser  Asp Pro Glu Val Leu  Leu Gln Ile 
    1250                 1255                 1260             


Asp Gly  Val Thr Glu Asp Lys  Leu Glu Lys Tyr Gly  Ala Glu Val 
    1265                 1270                 1275             


Ile Ser  Val Leu Gln Lys Tyr  Ser Glu Trp Thr Ser  Pro Ala Glu 
    1280                 1285                 1290             


Asp Ser  Ser Pro Gly Ile Ser  Leu Ser Ser Ser Arg  Gly Pro Gly 
    1295                 1300                 1305             


Arg Ser  Ala Ala Glu Glu Leu  Asp Glu Glu Ile Pro  Val Ser Ser 
    1310                 1315                 1320             


His Tyr  Phe Ala Ser Lys Thr  Arg Asn Glu Arg Lys  Arg Lys Lys 
    1325                 1330                 1335             


Met Pro  Ala Ser Gln Arg Ser  Lys Arg Arg Lys Thr  Ala Ser Ser 
    1340                 1345                 1350             


Gly Ser  Lys Ala Lys Gly Gly  Ser Ala Thr Cys Arg  Lys Ile Ser 
    1355                 1360                 1365             


Ser Lys  Thr Lys Ser Ser Ser  Ile Ile Gly Ser Ser  Ser Ala Ser 
    1370                 1375                 1380             


His Thr  Ser Gln Ala Thr Ser  Gly Ala Asn Ser Lys  Leu Gly Ile 
    1385                 1390                 1395             


Met Ala  Pro Pro Lys Pro Ile  Asn Arg Pro Phe Leu  Lys Pro Ser 
    1400                 1405                 1410             


Tyr Ala  Phe Ser 
    1415         


<210>  7
<211>  1001
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ile Phe Pro Val Ala Arg Tyr Ala Leu Arg Trp Leu Arg Arg Pro 
1               5                   10                  15      


Glu Asp Arg Ala Phe Ser Arg Ala Ala Met Glu Met Ala Leu Arg Gly 
            20                  25                  30          


Val Arg Lys Val Leu Cys Val Ala Glu Lys Asn Asp Ala Ala Lys Gly 
        35                  40                  45              


Ile Ala Asp Leu Leu Ser Asn Gly Arg Met Arg Arg Arg Glu Gly Leu 
    50                  55                  60                  


Ser Lys Phe Asn Lys Ile Tyr Glu Phe Asp Tyr His Leu Tyr Gly Gln 
65                  70                  75                  80  


Asn Val Thr Met Val Met Thr Ser Val Ser Gly His Leu Leu Ala His 
                85                  90                  95      


Asp Phe Gln Met Gln Phe Arg Lys Trp Gln Ser Cys Asn Pro Leu Val 
            100                 105                 110         


Leu Phe Glu Ala Glu Ile Glu Lys Tyr Cys Pro Glu Asn Phe Val Asp 
        115                 120                 125             


Ile Lys Lys Thr Leu Glu Arg Glu Thr Arg Gln Cys Gln Ala Leu Val 
    130                 135                 140                 


Ile Trp Thr Asp Cys Asp Arg Glu Gly Glu Asn Ile Gly Phe Glu Ile 
145                 150                 155                 160 


Ile His Val Cys Lys Ala Val Lys Pro Asn Leu Gln Val Leu Arg Ala 
                165                 170                 175     


Arg Phe Ser Glu Ile Thr Pro His Ala Val Arg Thr Ala Cys Glu Asn 
            180                 185                 190         


Leu Thr Glu Pro Asp Gln Arg Val Ser Asp Ala Val Asp Val Arg Gln 
        195                 200                 205             


Glu Leu Asp Leu Arg Ile Gly Ala Ala Phe Thr Arg Phe Gln Thr Leu 
    210                 215                 220                 


Arg Leu Gln Arg Ile Phe Pro Glu Val Leu Ala Glu Gln Leu Ile Ser 
225                 230                 235                 240 


Tyr Gly Ser Cys Gln Phe Pro Thr Leu Gly Phe Val Val Glu Arg Phe 
                245                 250                 255     


Lys Ala Ile Gln Ala Phe Val Pro Glu Ile Phe His Arg Ile Lys Val 
            260                 265                 270         


Thr His Asp His Lys Asp Gly Ile Val Glu Phe Asn Trp Lys Arg His 
        275                 280                 285             


Arg Leu Phe Asn His Thr Ala Cys Leu Val Leu Tyr Gln Leu Cys Val 
    290                 295                 300                 


Glu Asp Pro Met Ala Thr Val Val Glu Val Arg Ser Lys Pro Lys Ser 
305                 310                 315                 320 


Lys Trp Arg Pro Gln Ala Leu Asp Thr Val Glu Leu Glu Lys Leu Ala 
                325                 330                 335     


Ser Arg Lys Leu Arg Ile Asn Ala Lys Glu Thr Met Arg Ile Ala Glu 
            340                 345                 350         


Lys Leu Tyr Thr Gln Gly Tyr Ile Ser Tyr Pro Arg Thr Glu Thr Asn 
        355                 360                 365             


Ile Phe Pro Arg Asp Leu Asn Leu Thr Val Leu Val Glu Gln Gln Thr 
    370                 375                 380                 


Pro Asp Pro Arg Trp Gly Ala Phe Ala Gln Ser Ile Leu Glu Arg Gly 
385                 390                 395                 400 


Gly Pro Thr Pro Arg Asn Gly Asn Lys Ser Asp Gln Ala His Pro Pro 
                405                 410                 415     


Ile His Pro Thr Lys Tyr Thr Asn Asn Leu Gln Gly Asp Glu Gln Arg 
            420                 425                 430         


Leu Tyr Glu Phe Ile Val Arg His Phe Leu Ala Cys Cys Ser Gln Asp 
        435                 440                 445             


Ala Gln Gly Gln Glu Thr Thr Val Glu Ile Asp Ile Ala Gln Glu Arg 
    450                 455                 460                 


Phe Val Ala His Gly Leu Met Ile Leu Ala Arg Asn Tyr Leu Asp Val 
465                 470                 475                 480 


Tyr Pro Tyr Asp His Trp Ser Asp Lys Ile Leu Pro Val Tyr Glu Gln 
                485                 490                 495     


Gly Ser His Phe Gln Pro Ser Thr Val Glu Met Val Asp Gly Glu Thr 
            500                 505                 510         


Ser Pro Pro Lys Leu Leu Thr Glu Ala Asp Leu Ile Ala Leu Met Glu 
        515                 520                 525             


Lys His Gly Ile Gly Thr Asp Ala Thr His Ala Glu His Ile Glu Thr 
    530                 535                 540                 


Ile Lys Ala Arg Met Tyr Val Gly Leu Thr Pro Asp Lys Arg Phe Leu 
545                 550                 555                 560 


Pro Gly His Leu Gly Met Gly Leu Val Glu Gly Tyr Asp Ser Met Gly 
                565                 570                 575     


Tyr Glu Met Ser Lys Pro Asp Leu Arg Ala Glu Leu Glu Ala Asp Leu 
            580                 585                 590         


Lys Leu Ile Cys Asp Gly Lys Lys Asp Lys Phe Val Val Leu Arg Gln 
        595                 600                 605             


Gln Val Gln Lys Tyr Lys Gln Val Phe Ile Glu Ala Val Ala Lys Ala 
    610                 615                 620                 


Lys Lys Leu Asp Glu Ala Leu Ala Gln Tyr Phe Gly Asn Gly Thr Glu 
625                 630                 635                 640 


Leu Ala Gln Gln Glu Asp Ile Tyr Pro Ala Met Pro Glu Pro Ile Arg 
                645                 650                 655     


Lys Cys Pro Gln Cys Asn Lys Asp Met Val Leu Lys Thr Lys Lys Asn 
            660                 665                 670         


Gly Gly Phe Tyr Leu Ser Cys Met Gly Phe Pro Glu Cys Arg Ser Ala 
        675                 680                 685             


Val Trp Leu Pro Asp Ser Val Leu Glu Ala Ser Arg Asp Ser Ser Val 
    690                 695                 700                 


Cys Pro Val Cys Gln Pro His Pro Val Tyr Arg Leu Lys Leu Lys Phe 
705                 710                 715                 720 


Lys Arg Gly Ser Leu Pro Pro Thr Met Pro Leu Glu Phe Val Cys Cys 
                725                 730                 735     


Ile Gly Gly Cys Asp Asp Thr Leu Arg Glu Ile Leu Asp Leu Arg Phe 
            740                 745                 750         


Ser Gly Gly Pro Pro Arg Ala Ser Gln Pro Ser Gly Arg Leu Gln Ala 
        755                 760                 765             


Asn Gln Ser Leu Asn Arg Met Asp Asn Ser Gln His Pro Gln Pro Ala 
    770                 775                 780                 


Asp Ser Arg Gln Thr Gly Ser Ser Lys Ala Leu Ala Gln Thr Leu Pro 
785                 790                 795                 800 


Pro Pro Thr Ala Ala Gly Glu Ser Asn Ser Val Thr Cys Asn Cys Gly 
                805                 810                 815     


Gln Glu Ala Val Leu Leu Thr Val Arg Lys Glu Gly Pro Asn Arg Gly 
            820                 825                 830         


Arg Gln Phe Phe Lys Cys Asn Gly Gly Ser Cys Asn Phe Phe Leu Trp 
        835                 840                 845             


Ala Asp Ser Pro Asn Pro Gly Ala Gly Gly Pro Pro Ala Leu Ala Tyr 
    850                 855                 860                 


Arg Pro Leu Gly Ala Ser Leu Gly Cys Pro Pro Gly Pro Gly Ile His 
865                 870                 875                 880 


Leu Gly Gly Phe Gly Asn Pro Gly Asp Gly Ser Gly Ser Gly Thr Ser 
                885                 890                 895     


Cys Leu Cys Ser Gln Pro Ser Val Thr Arg Thr Val Gln Lys Asp Gly 
            900                 905                 910         


Pro Asn Lys Gly Arg Gln Phe His Thr Cys Ala Lys Pro Arg Glu Gln 
        915                 920                 925             


Gln Cys Gly Phe Phe Gln Trp Val Asp Glu Asn Thr Ala Pro Gly Thr 
    930                 935                 940                 


Ser Gly Ala Pro Ser Trp Thr Gly Asp Arg Gly Arg Thr Leu Glu Ser 
945                 950                 955                 960 


Glu Ala Arg Ser Lys Arg Pro Arg Ala Ser Ser Ser Asp Met Gly Ser 
                965                 970                 975     


Thr Ala Lys Lys Pro Arg Lys Cys Ser Leu Cys His Gln Pro Gly His 
            980                 985                 990         


Thr Arg Pro Phe Cys Pro Gln Asn  Arg 
        995                 1000     


<210>  8
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  9
<211>  6147
<212>  DNA
<213>  Homo sapiens

<400>  9
atgagcggac ggcaaagaac gctttttcag acgtggggct caagtatctc ccgatcatct       60

gggactccgg gttgcagctc cggaactgag cgacctcaga gccctggcag ctccaaggcg      120

cctttgccag cagcagcgga ggctcagctg gagtcggacg atgatgtgtt gcttgtcgcg      180

gcgtacgagg ctgagcggca gttgtgtcta gagaatggcg ggttctgcac ctccgcgggc      240

gccctgtgga tttaccctac caattgccca gtgcgggact accagctgca catttcccgg      300

gctgctctgt tttgcaatac gctggtgtgt ctgcctaccg gactgggaaa gacctttatt      360

gccgccgtgg tcatgtacaa tttctaccgc tggttccctt caggaaaggt ggtcttcatg      420

gccccaacga aacccttggt gacacagcag atcgaggctt gctaccaggt gatgggtatc      480

ccgcaatccc acatggccga aatgacaggg tctacacaag cttccaccag gaaggaaata      540

tggtgcagta agagagtgct ttttcttaca cctcaggtca tggtaaatga cctttctaga      600

ggagcttgtc ccgctgctga aataaagtgt ttagttattg atgaagctca taaagctctc      660

ggaaactatg cttattgcca ggttgtaaga gaactagtca aatatacaaa tcactttaga      720

atcttggctc taagtgccac accaggtagt gatataaagg ctgtgcaaca agttattact      780

aacctgctaa ttgggcagat agagcttcgt tctgaagatt ctccagatat tttgacatat      840

tctcatgaaa gaaaagttga aaagcttatt gttccgcttg gtgaagaact tgcagccatc      900

caaaagacct atatccagat tttggaatca tttgctcgtt ctttgattca gaggaatgtt      960

ttgatgagaa gggatatccc aaatctaaca aaatatcaga taattctggc aagagatcag     1020

tttaggaaaa acccatctcc gaatattgtg ggaatacaac aaggcataat cgagggagag     1080

tttgctattt gtattagttt atatcatggt tatgaattat tgcagcaaat gggaatgaga     1140

tcattatatt tcttcctttg tggaattatg gatggaacta aagggatgac acggtcaaaa     1200

aatgaacttg gccgaaatga agacttcatg aaactctata atcatctaga gtgtatgttt     1260

gcacgtacac gtagtacttc agcaaatggt atttctgcta tccaacaagg agataaaaat     1320

aaaaaatttg tttatagtca tccaaagtta aagaaattag aagaagttgt aattgaacac     1380

ttcaagtcat ggaatgctga aaacactact gaaaagaaac gtgatgagac ccgagttatg     1440

atcttctctt catttcgaga tagtgttcaa gaaattgcag aaatgctttc acagcatcag     1500

ccaattatta gagtaatgac ttttgtcggc catgcctcag ggaaaagcac gaagggtttt     1560

acccagaagg agcaactgga ggtagtgaaa cagtttcgtg acggtggtta caacacgctg     1620

gtttctacct gtgtgggtga agaaggtttg gatataggag aagttgatct tataatatgt     1680

tttgattccc agaagagccc aattcgtctt gtacaacgaa tgggtagaac tggccgtaaa     1740

cgtcaaggca ggatagttat tatcctttct gaaggacgag aggaacgtat ttataatcag     1800

agtcagtcca acaaaagaag tatatataaa gctatttcaa gtaacaggca ggtccttcat     1860

ttttaccaaa gaagtccacg aatggttcct gatggaatca acccaaaatt acacaaaatg     1920

ttcatcacac atggtgtcta tgaaccagag aagccttctc ggaacttgca gcgaaagtca     1980

tctatctttt cctataggga tggaatgagg caaagtagcc taaagaaaga ttggttctta     2040

tcagaagaag aatttaaatt atggaacaga ctttatagat taagggacag tgatgaaatt     2100

aaagagataa cattgcctca agttcagttt tcttctttac aaaatgagga aaacaaacca     2160

gctcaagaat caaccactgg aattcatcaa ctctctctct ctgaatggag actgtggcaa     2220

gatcatcctt tgcctacaca tcaagttgat cactcagatc gatgccgcca ttttataggc     2280

cttatgcaaa tgatagaggg aatgagacac gaagagggag aatgcagcta tgaattggaa     2340

gttgaatctt atttacaaat ggaagatgtt acctcaacat ttattgctcc caggaatgaa     2400

tctaataatc ttgccagtga cacctttatc actcacaaga aatcgtcatt tataaagaac     2460

ataaatcaag gcagttcatc ctcagtgata gaatctgatg aagaatgtgc tgaaattgtt     2520

aaacaaactc atatcaaacc tactaaaatt gtttctttaa agaaaaaagt gtctaaagaa     2580

ataaaaaaag atcagcttaa aaaagaaaat aatcacggta ttatagattc tgtagataat     2640

gacagaaatt ccactgttga aaatattttt caagaagacc taccaaatga taaaaggaca     2700

tcagatacag atgaaattgc tgccacatgt actattaatg aaaatgttat taaagaaccg     2760

tgtgtgttat taacagagtg tcagtttaca aataaatcca ctagttcact tgctggaaat     2820

gttttagatt ctggttataa cagtttcaat gatgaaaaat ctgtttcatc taacttattt     2880

cttccattcg aagaagagct ttatattgtt agaacagatg accaatttta taattgtcac     2940

tcattgacaa aagaggtact agctaatgta gagagatttt tatcttattc tcctccgcct     3000

ctcagtggac tctcagactt ggaatatgaa attgctaagg gtactgcact tgagaatttg     3060

cttttcttac cctgtgcaga gcatttacga agtgataaat gcacctgttt gctgtcacat     3120

tcagctgtga attctcaaca gaatttagaa ttgaattcac ttaaatgtat aaattatcca     3180

tctgaaaaaa gttgccttta tgatatacct aatgataata tttctgatga gccaagtctc     3240

tgtgactgtg atgtacataa acataatcaa aatgaaaatt tagtacctaa caatcgtgtt     3300

caaatacaca gaagccctgc acagaattta gttggagaga acaatcatga tgttgataac     3360

agtgacctcc cagtattgtc cactgatcaa gatgaaagtt tgctgttatt tgaagatgtt     3420

aatacagagt tcgacgatgt gagtctttca cccttgaaca gtaaaagcga atctttacct     3480

gtgtcagaca aaactgctat tagtgaaacg cctctggtct ctcagttctt aatttctgat     3540

gaacttttgt tggacaataa ttctgaactc caagatcaaa tcacccgtga tgctaatagt     3600

tttaaatctc gtgatcagag aggtgtacag gaagaaaaag tgaagaatca tgaggatatt     3660

tttgattgct ctagggattt attttctgtt acctttgatt taggattctg tagtccagat     3720

tctgatgatg aaatattgga acatacatca gatagcaata gacctctaga tgatctatat     3780

ggaaggtatt tggaaattaa ggagataagt gatgcaaatt atgtttcgaa tcaagcacta     3840

ataccaagag atcatagtaa aaattttact agtggaactg ttattatccc atcaaatgaa     3900

gatatgcaga atccaaatta tgtacatttg ccactgagtg cagcaaaaaa tgaagaattg     3960

ttatctcctg gttattctca gttttcttta ccagtgcaaa aaaaagttat gagtacacca     4020

ctctctaaat caaacacatt gaactcattt tctaagataa gaaaggaaat acttaagaca     4080

ccagattcta gtaaggaaaa agtaaaccta caaagattca aagaagcatt gaattcaact     4140

tttgattatt cagaattttc tctagaaaag tctaaaagca gtggtccaat gtatctgcat     4200

aaatcctgtc attctgttga agatggacaa ttattaacaa gtaacgaaag tgaagatgac     4260

gagattttcc gaagaaaagt taaaagagca aaaggaaatg ttttaaactc tcctgaggat     4320

cagaaaaata gtgaagttga ttctccactt catgctgtca aaaagcgcag atttcctata     4380

aacagatcag aattatcatc tagtgatgag agtgagaatt ttcccaaacc atgttcacaa     4440

ttagaagact tcaaggtttg taacgggaat gccagaagag gcatcaaagt cccaaagaga     4500

cagagtcact taaagcatgt agctaggaag tttttagatg atgaagcaga actttctgaa     4560

gaagatgcag aatatgtttc atcagatgaa aatgatgagt cagaaaatga acaagattcc     4620

tcattacttg actttttaaa tgatgaaact caactttcac aggctataaa tgattctgaa     4680

atgagagcta tttacatgaa atctttgcgt agtccaatga tgaacaataa gtacaaaatg     4740

attcataaga cacataaaaa cataaacatt ttctcgcaga ttcctgaaca agatgaaacc     4800

tatttagagg atagtttttg tgttgatgaa gaggagtctt gcaaaggcca atcaagtgaa     4860

gaagaagttt gtgttgattt taacttaata actgatgatt gctttgcaaa tagtaaaaag     4920

tataaaactc gacgtgcagt aatgctaaaa gaaatgatgg aacaaaattg tgcacattca     4980

aaaaagaaat tatccagaat tattttacca gatgattcaa gtgaggagga gaacaatgta     5040

aatgataaaa gagaatctaa tattgcggtt aacccaagca ctgttaagaa gaacaaacaa     5100

caggaccatt gtttaaattc agtgccttct ggatcttctg cgcagtccaa ggtgcgttct     5160

actccaagag ttaatccatt agcaaagcag agcaaacaga catcgctgaa tttaaaggat     5220

acaatttccg aagtctcaga cttcaaacct cagaatcata atgaagtcca gtctaccaca     5280

ccacccttca ctactgttga ttcacagaaa gactgtagaa aatttccagt tccacagaag     5340

gatggtagtg ctttggagga ttctagcact tcaggggcat cctgttccaa gtcaagacca     5400

catttagctg ggacacatac ttctcttaga cttccgcagg aaggaaaagg aacctgtatt     5460

cttgtaggtg gtcatgaaat cacttctgga ttagaagtaa tttcttccct aagagcaatt     5520

catgggttgc aagtagaagt ttgtcctctt aatggctgtg attacatcgt gagtaatcgc     5580

atggtggtgg aaaggaggtc tcaatctgag atgttaaata gtgtcaataa gaacaagttc     5640

attgagcaga tccagcacct gcagagtatg tttgaaagaa tatgtgtgat tgtggaaaag     5700

gacagagaaa aaacaggaga cacatcaagg atgtttagga gaacaaagag ctatgacagc     5760

ctgctgacta ccttaattgg cgctggaatc cgaattcttt tcagttcctg ccaagaagaa     5820

accgcagatt tgctaaagga actgtcttta gtggaacaaa gaaagaatgt tggtattcat     5880

gttccaacag tggtgaatag taataaaagt gaggcactcc agttttattt aagtattccc     5940

aatataagtt atataactgc attaaatatg tgtcaccagt tttcatctgt gaaaaggatg     6000

gctaacagct cacttcaaga aatctccatg tatgcacaag taactcatca gaaggctgag     6060

gagatctata gatatattca ctatgtattt gacatacaaa tgttaccaaa tgatcttaac     6120

caagatagac tgaaatctga tatataa                                         6147


<210>  10
<211>  3395
<212>  DNA
<213>  Homo sapiens

<400>  10
gttttccagc cccgaaggag tcctttgggg ttggaggagg ggcgcgagcg cgcggcaaat       60

cgggcgggaa gaggtaaaaa aggaactggg agcgcgccgc ggcggttcct gtccttacag      120

ttgcgctgcc cagggaccga tgttgcgcga ggaaaatgcg ggacgcccag ggccatttct      180

gagcagtgga ggtttcaagt aatccactaa caaccagttc caaattctgt catcaaatcc      240

tgtgctgctg ttcctcgtgg taatagatgc atattatttc ttttatttaa aagaaatgaa      300

tgtgactagt attgcattaa gagctgaaac ttggctttta gctgcatggc atgttaaagt      360

acctccgatg tggctggaag cttgtattaa ctggattcaa gaagaaaata ataatgttaa      420

cttgagtcag gcccaaatga ataaacaagt gtttgagcag tggctcctta ctgatctgag      480

ggatttggag catcctcttt tacccgatgg cattttagaa attccaaaag gagaattaaa      540

tggattttat gctctgcaga ttaattcctt ggttgatgta agtcagcctg catactccca      600

gatacagaag ttgagaggaa agaatacaac aaatgatcta gttacagctg aagcacaagt      660

aaccccaaaa ccttgggaag caaagccttc acgaatgttg atgctgcagc taactgatgg      720

aatcgtacaa atacagggaa tggaatatca gcctattcca attcttcata gtgatcttcc      780

tccaggtaca aaaattttga tttatggaaa tatatctttc cgtcttggtg ttctcttatt      840

gaaaccagaa aacgtgaaag tgttaggagg tgaagtagat gctcttttag aagaatatgc      900

ccaagaaaaa gtacttgcaa gattaatagg ggaacctgat cttgtagttt cagtcatacc      960

aaacaattct aacgaaaaca ttcccagagt tacagatgtt ctagatcctg cattaggtcc     1020

ttctgatgaa gaactcttgg caagtcttga tgaaaatgat gagcttacag caaataatga     1080

cacttcctca gaacgatgtt tcaccacagg tagttcctca aataccattc ccacaagaca     1140

gtcaagtttt gagccagaat ttgttatttc tccaagacca aaagaggaac catcaaacct     1200

atctatacat gtaatggatg gagaattaga tgacttttca ctggaggagg ccttgctttt     1260

agaagaaact gtccagaaag aacagatgga aactaaggaa ttgcaaccat tgacttttaa     1320

cagaaatgcc gatcgaagta tagagagatt ttcacataat cctaatacta cgaataactt     1380

ttctttgact tgcaaaaatg gaaacaataa ttggagtgaa aaaaatgtat ctgaacaaat     1440

gactaatgaa gacaaatcat ttggttgtcc atctgttaga gaccaaaaca ggagtatttt     1500

ttcagttcat tgtaatgtac ccttagccca tgattttaca aataaagaaa agaacttaga     1560

gacagataat aaaataaaac aaaccagcag ttcagatagc cattccttaa ataataaaat     1620

attaaataga gaggtggtca actatgtaca gaaaaggaat tcacaaattt ctaatgaaaa     1680

tgattgtaat ttacagagtt gttctttaag atcatcagag aatagcatta atctttctat     1740

tgccatggat ttgtattctc caccctttgt ctatttgtct gttctaatgg ccagcaaacc     1800

aaaggaagtt acaacagtga aagtgaaagc atttattgta accttaactg gaaatctctc     1860

aagttctggt ggtatttgga gtataactgc aaaggtgtct gatggtactg catatctaga     1920

tgtagacttt gtggatgaaa tacttactag cttgataggg ttctcagtac cagaaatgaa     1980

acagtcaaaa aaggatcctc ttcaatacca aaagttcctg gaagggttgc agaaatgtca     2040

aagagatcta atagatttgt gctgtctaat gactatttca tttaatcctt ccttgtctaa     2100

agcaatggta ctggcattac aagatgttaa tatggaacac cttgagaatc taaagaagcg     2160

gttaaataaa taattaaact aaaatagtat taggaacaat taaaaacaac aaggaaatat     2220

ttagaatttg ttcacaattt tacttatgat actttgtgta aaaaggaaaa atgaaatttc     2280

atagcttatt tcagtttaat tttaaagtgt ttaatcatgt ttgttatatg tggagctttt     2340

gaaaataagt taatcttttt tttttttttt ttaatgtcag ggtattgctc tgttgcccag     2400

gctagagtgc agtggcatga tcataggtta ttgcatcaac ctcttgagct caagcgatcc     2460

tcctgcctta gcctcttgag ttgctgggac tataggcatg taccaccatg cccagctaat     2520

ttataattac tattattgtt ttgtagggac agagttttgc tatgttgccc agattggtct     2580

caaactcctg gcctctcact cctgccgtca tggcctccaa agtttacttt ttttaaaagt     2640

aactgttaga tggaggaata tggtgaccca ctattgttga gaaatttgtt ttccacttgt     2700

cacgtcacat aagatgattg ctaaaatatt gtactggtgt tcggtggtga gtcatatttt     2760

tgaaagttaa taattataaa taggtaattt ccttctaata tgttggtact gtctatggcc     2820

ataccaccct gaacatgcct gagcttgtca taatatgttg agtacccaaa agatttgttt     2880

atattgttaa tcttagggaa aaaaaattaa aatccagtag atcagaacat caggctttca     2940

gatacaaatt gatttactgg tttttatttt gctgattata atatttggta tatttaaggt     3000

aatctagtta actagatgct atttcataga ttatattgaa tgatttaaaa ctttattttc     3060

aaggatagtt tattttaaat ggcatattga aaacatcatt attaagatcc agtaggtagg     3120

acatttattg gattaaaatg aagcatttat ctatgtcttt aggtgtcatt gttccctttc     3180

tgaattagct gtacatataa gccttccttt ggttttaagt actgattttt ttttaaaaaa     3240

aagagggact gtttaccatt cttccactgt gctgttataa agttgtattt gaaaggtaat     3300

gttgttttta ttaatctttt gtcttaaaat aatttaaagt gctttgaatt ttaaaacatt     3360

aaacaaatcc ttaaataaca aaaaaaaaaa aaaaa                                3395


<210>  11
<211>  1427
<212>  DNA
<213>  Homo sapiens

<400>  11
gcggcgaggc ggaatggcgg cggctgcgga ctcgttctca ggcggccccg cgggggtgcg       60

gcttccgagg tcgccgccac tcaaggtgct ggcggagcag ctgcggcgcg acgcggaggg      120

cggcccgggc gcgtggcggc tgtcacgggc ggcggcgggc cgcgggccgc tggacctggc      180

ggccgtgtgg atgcagggca gggtagtgat ggcggaccgc ggcgaggctc ggctgaggga      240

cccgagcggg gacttctcgg tccgcggcct ggagcgggtg ccgcgcgggc ggccctgtct      300

agtcccagga aagtatgtga tggtgatggg agtggttcag gcctgcagcc ctgagccctg      360

cctgcaggct gtgaagatga cagacctttc tgataatccc atccatgaaa gtatgtggga      420

actggaggta gaagatttac acaggaatat tccttagagt atgttggaac tgtcgttaaa      480

aacaaccaaa atcccgaaac tatttagaag cttataatga tgtggatttc atggacactt      540

ttcaatgcgt atttttcaaa tgcttctcag agagccttgc tttggttgac caaggagtcc      600

ggatgtagga atgtttaaat cctcggatac ttcagtgaca cagcctctgc tgccccttgc      660

tttgcctgtg tttgctgatg aaaagcagat gcttgtgttt cattttcctt cctggtttgt      720

gtgtgttaat tctctctctc tctctcagac acagaagtct catgttgcat tttccaaatt      780

ttatgagtga tgatactttt tccattactg ctgcgtccct gttttacaat gcaaaattta      840

agtacggtcg ttgcccatgg tgattaaagt gtggttatgg gcaggaagac agactgtgta      900

aaaaaggaat gacatcctgg ctcctcatct tcttcatcag caactaccat aaccagtttg      960

cgagtcaaat ggcatttcct aacggcaggc atggcggccc ctgaaagaca acagctccct     1020

ttctgcttcg gacaccactc aaacatttag acgcagctct atcccttttc ctagctagag     1080

aaggtgatgc cttcttccat tactcagaga tgttgagacg ttttcagaat ttcttgttga     1140

aatgaaaaac atcaagataa aggacgcctt tcaggcatta gctaaacttc cacttcataa     1200

ctttcggcga gacatggtga gcctcctggt gtagagttct tttgtctttg tatggaatga     1260

ctttttgctg tgatggtttt gaatgttggg tttctgctgt ctgcttagta cccatgcctg     1320

aattttttga gattgtaaat atcaaaggag ttagattgtg ttctgacatg gttgtagact     1380

ttcacctgga ttattgatat tctacctcta ataaattttt aataggc                   1427


<210>  12
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siFANCM1

<400>  12
gcucguucuu ugauucaga                                                    19


<210>  13
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siFANCM2

<400>  13
gaacauacau cagauagca                                                    19


<210>  14
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siPOLD3

<400>  14
gaugcuguau gauuauguu                                                    19


<210>  15
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siBLM

<400>  15
ggauguucuu agcacauca                                                    19


<210>  16
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRAD51

<400>  16
cagugguaau cacuaauca                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRAD52

<400>  17
gacuaccuga gaucacuaa                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRMI1

<400>  18
gaguuguucu uuaagauca                                                    19


<210>  19
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant FANCM protein (PIP)

<400>  19

Met Ser Gly Arg Gln Arg Thr Arg Phe Gln Thr Ser Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  20
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein (K117R)

<400>  20

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Arg Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  21
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein (MID)

<400>  21

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Gly Asp Gly Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  22
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein (S1045A)

<400>  22

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ala  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  23
<211>  1986
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein delta MM1

<400>  23

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Ser Asp 
    930                 935                 940                 


Leu Glu Tyr Glu Ile Ala Lys Gly Thr Ala Leu Glu Asn Leu Leu Phe 
945                 950                 955                 960 


Leu Pro Cys Ala Glu His Leu Arg Ser Asp Lys Cys Thr Cys Leu Leu 
                965                 970                 975     


Ser His Ser Ala Val Asn Ser Gln Gln Asn Leu Glu Leu Asn Ser Leu 
            980                 985                 990         


Lys Cys Ile Asn Tyr Pro Ser Glu  Lys Ser Cys Leu Tyr  Asp Ile Pro 
        995                 1000                 1005             


Asn Asp  Asn Ile Ser Asp Glu  Pro Ser Leu Cys Asp  Cys Asp Val 
    1010                 1015                 1020             


His Lys  His Asn Gln Asn Glu  Asn Leu Val Pro Asn  Asn Arg Val 
    1025                 1030                 1035             


Gln Ile  His Arg Ser Pro Ala  Gln Asn Leu Val Gly  Glu Asn Asn 
    1040                 1045                 1050             


His Asp  Val Asp Asn Ser Asp  Leu Pro Val Leu Ser  Thr Asp Gln 
    1055                 1060                 1065             


Asp Glu  Ser Leu Leu Leu Phe  Glu Asp Val Asn Thr  Glu Phe Asp 
    1070                 1075                 1080             


Asp Val  Ser Leu Ser Pro Leu  Asn Ser Lys Ser Glu  Ser Leu Pro 
    1085                 1090                 1095             


Val Ser  Asp Lys Thr Ala Ile  Ser Glu Thr Pro Leu  Val Ser Gln 
    1100                 1105                 1110             


Phe Leu  Ile Ser Asp Glu Leu  Leu Leu Asp Asn Asn  Ser Glu Leu 
    1115                 1120                 1125             


Gln Asp  Gln Ile Thr Arg Asp  Ala Asn Ser Phe Lys  Ser Arg Asp 
    1130                 1135                 1140             


Gln Arg  Gly Val Gln Glu Glu  Lys Val Lys Asn His  Glu Asp Ile 
    1145                 1150                 1155             


Phe Asp  Cys Ser Arg Asp Leu  Phe Ser Val Thr Phe  Asp Leu Gly 
    1160                 1165                 1170             


Phe Cys  Ser Pro Asp Ser Asp  Asp Glu Ile Leu Glu  His Thr Ser 
    1175                 1180                 1185             


Asp Ser  Asn Arg Pro Leu Asp  Asp Leu Tyr Gly Arg  Tyr Leu Glu 
    1190                 1195                 1200             


Ile Lys  Glu Ile Ser Asp Ala  Asn Tyr Val Ser Asn  Gln Ala Leu 
    1205                 1210                 1215             


Ile Pro  Arg Asp His Ser Lys  Asn Phe Thr Ser Gly  Thr Val Ile 
    1220                 1225                 1230             


Ile Pro  Ser Asn Glu Asp Met  Gln Asn Pro Asn Tyr  Val His Leu 
    1235                 1240                 1245             


Pro Leu  Ser Ala Ala Lys Asn  Glu Glu Leu Leu Ser  Pro Gly Tyr 
    1250                 1255                 1260             


Ser Gln  Phe Ser Leu Pro Val  Gln Lys Lys Val Met  Ser Thr Pro 
    1265                 1270                 1275             


Leu Ser  Lys Ser Asn Thr Leu  Asn Ser Phe Ser Lys  Ile Arg Lys 
    1280                 1285                 1290             


Glu Ile  Leu Lys Thr Pro Asp  Ser Ser Lys Glu Lys  Val Asn Leu 
    1295                 1300                 1305             


Gln Arg  Phe Lys Glu Ala Leu  Asn Ser Thr Phe Asp  Tyr Ser Glu 
    1310                 1315                 1320             


Phe Ser  Leu Glu Lys Ser Lys  Ser Ser Gly Pro Met  Tyr Leu His 
    1325                 1330                 1335             


Lys Ser  Cys His Ser Val Glu  Asp Gly Gln Leu Leu  Thr Ser Asn 
    1340                 1345                 1350             


Glu Ser  Glu Asp Asp Glu Ile  Phe Arg Arg Lys Val  Lys Arg Ala 
    1355                 1360                 1365             


Lys Gly  Asn Val Leu Asn Ser  Pro Glu Asp Gln Lys  Asn Ser Glu 
    1370                 1375                 1380             


Val Asp  Ser Pro Leu His Ala  Val Lys Lys Arg Arg  Phe Pro Ile 
    1385                 1390                 1395             


Asn Arg  Ser Glu Leu Ser Ser  Ser Asp Glu Ser Glu  Asn Phe Pro 
    1400                 1405                 1410             


Lys Pro  Cys Ser Gln Leu Glu  Asp Phe Lys Val Cys  Asn Gly Asn 
    1415                 1420                 1425             


Ala Arg  Arg Gly Ile Lys Val  Pro Lys Arg Gln Ser  His Leu Lys 
    1430                 1435                 1440             


His Val  Ala Arg Lys Phe Leu  Asp Asp Glu Ala Glu  Leu Ser Glu 
    1445                 1450                 1455             


Glu Asp  Ala Glu Tyr Val Ser  Ser Asp Glu Asn Asp  Glu Ser Glu 
    1460                 1465                 1470             


Asn Glu  Gln Asp Ser Ser Leu  Leu Asp Phe Leu Asn  Asp Glu Thr 
    1475                 1480                 1485             


Gln Leu  Ser Gln Ala Ile Asn  Asp Ser Glu Met Arg  Ala Ile Tyr 
    1490                 1495                 1500             


Met Lys  Ser Leu Arg Ser Pro  Met Met Asn Asn Lys  Tyr Lys Met 
    1505                 1510                 1515             


Ile His  Lys Thr His Lys Asn  Ile Asn Ile Phe Ser  Gln Ile Pro 
    1520                 1525                 1530             


Glu Gln  Asp Glu Thr Tyr Leu  Glu Asp Ser Phe Cys  Val Asp Glu 
    1535                 1540                 1545             


Glu Glu  Ser Cys Lys Gly Gln  Ser Ser Glu Glu Glu  Val Cys Val 
    1550                 1555                 1560             


Asp Phe  Asn Leu Ile Thr Asp  Asp Cys Phe Ala Asn  Ser Lys Lys 
    1565                 1570                 1575             


Tyr Lys  Thr Arg Arg Ala Val  Met Leu Lys Glu Met  Met Glu Gln 
    1580                 1585                 1590             


Asn Cys  Ala His Ser Lys Lys  Lys Leu Ser Arg Ile  Ile Leu Pro 
    1595                 1600                 1605             


Asp Asp  Ser Ser Glu Glu Glu  Asn Asn Val Asn Asp  Lys Arg Glu 
    1610                 1615                 1620             


Ser Asn  Ile Ala Val Asn Pro  Ser Thr Val Lys Lys  Asn Lys Gln 
    1625                 1630                 1635             


Gln Asp  His Cys Leu Asn Ser  Val Pro Ser Gly Ser  Ser Ala Gln 
    1640                 1645                 1650             


Ser Lys  Val Arg Ser Thr Pro  Arg Val Asn Pro Leu  Ala Lys Gln 
    1655                 1660                 1665             


Ser Lys  Gln Thr Ser Leu Asn  Leu Lys Asp Thr Ile  Ser Glu Val 
    1670                 1675                 1680             


Ser Asp  Phe Lys Pro Gln Asn  His Asn Glu Val Gln  Ser Thr Thr 
    1685                 1690                 1695             


Pro Pro  Phe Thr Thr Val Asp  Ser Gln Lys Asp Cys  Arg Lys Phe 
    1700                 1705                 1710             


Pro Val  Pro Gln Lys Asp Gly  Ser Ala Leu Glu Asp  Ser Ser Thr 
    1715                 1720                 1725             


Ser Gly  Ala Ser Cys Ser Lys  Ser Arg Pro His Leu  Ala Gly Thr 
    1730                 1735                 1740             


His Thr  Ser Leu Arg Leu Pro  Gln Glu Gly Lys Gly  Thr Cys Ile 
    1745                 1750                 1755             


Leu Val  Gly Gly His Glu Ile  Thr Ser Gly Leu Glu  Val Ile Ser 
    1760                 1765                 1770             


Ser Leu  Arg Ala Ile His Gly  Leu Gln Val Glu Val  Cys Pro Leu 
    1775                 1780                 1785             


Asn Gly  Cys Asp Tyr Ile Val  Ser Asn Arg Met Val  Val Glu Arg 
    1790                 1795                 1800             


Arg Ser  Gln Ser Glu Met Leu  Asn Ser Val Asn Lys  Asn Lys Phe 
    1805                 1810                 1815             


Ile Glu  Gln Ile Gln His Leu  Gln Ser Met Phe Glu  Arg Ile Cys 
    1820                 1825                 1830             


Val Ile  Val Glu Lys Asp Arg  Glu Lys Thr Gly Asp  Thr Ser Arg 
    1835                 1840                 1845             


Met Phe  Arg Arg Thr Lys Ser  Tyr Asp Ser Leu Leu  Thr Thr Leu 
    1850                 1855                 1860             


Ile Gly  Ala Gly Ile Arg Ile  Leu Phe Ser Ser Cys  Gln Glu Glu 
    1865                 1870                 1875             


Thr Ala  Asp Leu Leu Lys Glu  Leu Ser Leu Val Glu  Gln Arg Lys 
    1880                 1885                 1890             


Asn Val  Gly Ile His Val Pro  Thr Val Val Asn Ser  Asn Lys Ser 
    1895                 1900                 1905             


Glu Ala  Leu Gln Phe Tyr Leu  Ser Ile Pro Asn Ile  Ser Tyr Ile 
    1910                 1915                 1920             


Thr Ala  Leu Asn Met Cys His  Gln Phe Ser Ser Val  Lys Arg Met 
    1925                 1930                 1935             


Ala Asn  Ser Ser Leu Gln Glu  Ile Ser Met Tyr Ala  Gln Val Thr 
    1940                 1945                 1950             


His Gln  Lys Ala Glu Glu Ile  Tyr Arg Tyr Ile His  Tyr Val Phe 
    1955                 1960                 1965             


Asp Ile  Gln Met Leu Pro Asn  Asp Leu Asn Gln Asp  Arg Leu Lys 
    1970                 1975                 1980             


Ser Asp  Ile 
    1985     


<210>  24
<211>  2015
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein delta MM2

<400>  24

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Ser Asn  Arg Pro Leu Asp Asp  Leu Tyr Gly Arg Tyr  Leu Glu Ile 
    1220                 1225                 1230             


Lys Glu  Ile Ser Asp Ala Asn  Tyr Val Ser Asn Gln  Ala Leu Ile 
    1235                 1240                 1245             


Pro Arg  Asp His Ser Lys Asn  Phe Thr Ser Gly Thr  Val Ile Ile 
    1250                 1255                 1260             


Pro Ser  Asn Glu Asp Met Gln  Asn Pro Asn Tyr Val  His Leu Pro 
    1265                 1270                 1275             


Leu Ser  Ala Ala Lys Asn Glu  Glu Leu Leu Ser Pro  Gly Tyr Ser 
    1280                 1285                 1290             


Gln Phe  Ser Leu Pro Val Gln  Lys Lys Val Met Ser  Thr Pro Leu 
    1295                 1300                 1305             


Ser Lys  Ser Asn Thr Leu Asn  Ser Phe Ser Lys Ile  Arg Lys Glu 
    1310                 1315                 1320             


Ile Leu  Lys Thr Pro Asp Ser  Ser Lys Glu Lys Val  Asn Leu Gln 
    1325                 1330                 1335             


Arg Phe  Lys Glu Ala Leu Asn  Ser Thr Phe Asp Tyr  Ser Glu Phe 
    1340                 1345                 1350             


Ser Leu  Glu Lys Ser Lys Ser  Ser Gly Pro Met Tyr  Leu His Lys 
    1355                 1360                 1365             


Ser Cys  His Ser Val Glu Asp  Gly Gln Leu Leu Thr  Ser Asn Glu 
    1370                 1375                 1380             


Ser Glu  Asp Asp Glu Ile Phe  Arg Arg Lys Val Lys  Arg Ala Lys 
    1385                 1390                 1395             


Gly Asn  Val Leu Asn Ser Pro  Glu Asp Gln Lys Asn  Ser Glu Val 
    1400                 1405                 1410             


Asp Ser  Pro Leu His Ala Val  Lys Lys Arg Arg Phe  Pro Ile Asn 
    1415                 1420                 1425             


Arg Ser  Glu Leu Ser Ser Ser  Asp Glu Ser Glu Asn  Phe Pro Lys 
    1430                 1435                 1440             


Pro Cys  Ser Gln Leu Glu Asp  Phe Lys Val Cys Asn  Gly Asn Ala 
    1445                 1450                 1455             


Arg Arg  Gly Ile Lys Val Pro  Lys Arg Gln Ser His  Leu Lys His 
    1460                 1465                 1470             


Val Ala  Arg Lys Phe Leu Asp  Asp Glu Ala Glu Leu  Ser Glu Glu 
    1475                 1480                 1485             


Asp Ala  Glu Tyr Val Ser Ser  Asp Glu Asn Asp Glu  Ser Glu Asn 
    1490                 1495                 1500             


Glu Gln  Asp Ser Ser Leu Leu  Asp Phe Leu Asn Asp  Glu Thr Gln 
    1505                 1510                 1515             


Leu Ser  Gln Ala Ile Asn Asp  Ser Glu Met Arg Ala  Ile Tyr Met 
    1520                 1525                 1530             


Lys Ser  Leu Arg Ser Pro Met  Met Asn Asn Lys Tyr  Lys Met Ile 
    1535                 1540                 1545             


His Lys  Thr His Lys Asn Ile  Asn Ile Phe Ser Gln  Ile Pro Glu 
    1550                 1555                 1560             


Gln Asp  Glu Thr Tyr Leu Glu  Asp Ser Phe Cys Val  Asp Glu Glu 
    1565                 1570                 1575             


Glu Ser  Cys Lys Gly Gln Ser  Ser Glu Glu Glu Val  Cys Val Asp 
    1580                 1585                 1590             


Phe Asn  Leu Ile Thr Asp Asp  Cys Phe Ala Asn Ser  Lys Lys Tyr 
    1595                 1600                 1605             


Lys Thr  Arg Arg Ala Val Met  Leu Lys Glu Met Met  Glu Gln Asn 
    1610                 1615                 1620             


Cys Ala  His Ser Lys Lys Lys  Leu Ser Arg Ile Ile  Leu Pro Asp 
    1625                 1630                 1635             


Asp Ser  Ser Glu Glu Glu Asn  Asn Val Asn Asp Lys  Arg Glu Ser 
    1640                 1645                 1650             


Asn Ile  Ala Val Asn Pro Ser  Thr Val Lys Lys Asn  Lys Gln Gln 
    1655                 1660                 1665             


Asp His  Cys Leu Asn Ser Val  Pro Ser Gly Ser Ser  Ala Gln Ser 
    1670                 1675                 1680             


Lys Val  Arg Ser Thr Pro Arg  Val Asn Pro Leu Ala  Lys Gln Ser 
    1685                 1690                 1695             


Lys Gln  Thr Ser Leu Asn Leu  Lys Asp Thr Ile Ser  Glu Val Ser 
    1700                 1705                 1710             


Asp Phe  Lys Pro Gln Asn His  Asn Glu Val Gln Ser  Thr Thr Pro 
    1715                 1720                 1725             


Pro Phe  Thr Thr Val Asp Ser  Gln Lys Asp Cys Arg  Lys Phe Pro 
    1730                 1735                 1740             


Val Pro  Gln Lys Asp Gly Ser  Ala Leu Glu Asp Ser  Ser Thr Ser 
    1745                 1750                 1755             


Gly Ala  Ser Cys Ser Lys Ser  Arg Pro His Leu Ala  Gly Thr His 
    1760                 1765                 1770             


Thr Ser  Leu Arg Leu Pro Gln  Glu Gly Lys Gly Thr  Cys Ile Leu 
    1775                 1780                 1785             


Val Gly  Gly His Glu Ile Thr  Ser Gly Leu Glu Val  Ile Ser Ser 
    1790                 1795                 1800             


Leu Arg  Ala Ile His Gly Leu  Gln Val Glu Val Cys  Pro Leu Asn 
    1805                 1810                 1815             


Gly Cys  Asp Tyr Ile Val Ser  Asn Arg Met Val Val  Glu Arg Arg 
    1820                 1825                 1830             


Ser Gln  Ser Glu Met Leu Asn  Ser Val Asn Lys Asn  Lys Phe Ile 
    1835                 1840                 1845             


Glu Gln  Ile Gln His Leu Gln  Ser Met Phe Glu Arg  Ile Cys Val 
    1850                 1855                 1860             


Ile Val  Glu Lys Asp Arg Glu  Lys Thr Gly Asp Thr  Ser Arg Met 
    1865                 1870                 1875             


Phe Arg  Arg Thr Lys Ser Tyr  Asp Ser Leu Leu Thr  Thr Leu Ile 
    1880                 1885                 1890             


Gly Ala  Gly Ile Arg Ile Leu  Phe Ser Ser Cys Gln  Glu Glu Thr 
    1895                 1900                 1905             


Ala Asp  Leu Leu Lys Glu Leu  Ser Leu Val Glu Gln  Arg Lys Asn 
    1910                 1915                 1920             


Val Gly  Ile His Val Pro Thr  Val Val Asn Ser Asn  Lys Ser Glu 
    1925                 1930                 1935             


Ala Leu  Gln Phe Tyr Leu Ser  Ile Pro Asn Ile Ser  Tyr Ile Thr 
    1940                 1945                 1950             


Ala Leu  Asn Met Cys His Gln  Phe Ser Ser Val Lys  Arg Met Ala 
    1955                 1960                 1965             


Asn Ser  Ser Leu Gln Glu Ile  Ser Met Tyr Ala Gln  Val Thr His 
    1970                 1975                 1980             


Gln Lys  Ala Glu Glu Ile Tyr  Arg Tyr Ile His Tyr  Val Phe Asp 
    1985                 1990                 1995             


Ile Gln  Met Leu Pro Asn Asp  Leu Asn Gln Asp Arg  Leu Lys Ser 
    2000                 2005                 2010             


Asp Ile  
    2015 


<210>  25
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM FF>AA

<400>  25

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Ala Asp 
    1220                 1225                 1230             


Leu Gly  Ala Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  26
<211>  1677
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein delta MM3

<400>  26

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Val Pro 
    1325                 1330                 1335             


Ser Gly  Ser Ser Ala Gln Ser  Lys Val Arg Ser Thr  Pro Arg Val 
    1340                 1345                 1350             


Asn Pro  Leu Ala Lys Gln Ser  Lys Gln Thr Ser Leu  Asn Leu Lys 
    1355                 1360                 1365             


Asp Thr  Ile Ser Glu Val Ser  Asp Phe Lys Pro Gln  Asn His Asn 
    1370                 1375                 1380             


Glu Val  Gln Ser Thr Thr Pro  Pro Phe Thr Thr Val  Asp Ser Gln 
    1385                 1390                 1395             


Lys Asp  Cys Arg Lys Phe Pro  Val Pro Gln Lys Asp  Gly Ser Ala 
    1400                 1405                 1410             


Leu Glu  Asp Ser Ser Thr Ser  Gly Ala Ser Cys Ser  Lys Ser Arg 
    1415                 1420                 1425             


Pro His  Leu Ala Gly Thr His  Thr Ser Leu Arg Leu  Pro Gln Glu 
    1430                 1435                 1440             


Gly Lys  Gly Thr Cys Ile Leu  Val Gly Gly His Glu  Ile Thr Ser 
    1445                 1450                 1455             


Gly Leu  Glu Val Ile Ser Ser  Leu Arg Ala Ile His  Gly Leu Gln 
    1460                 1465                 1470             


Val Glu  Val Cys Pro Leu Asn  Gly Cys Asp Tyr Ile  Val Ser Asn 
    1475                 1480                 1485             


Arg Met  Val Val Glu Arg Arg  Ser Gln Ser Glu Met  Leu Asn Ser 
    1490                 1495                 1500             


Val Asn  Lys Asn Lys Phe Ile  Glu Gln Ile Gln His  Leu Gln Ser 
    1505                 1510                 1515             


Met Phe  Glu Arg Ile Cys Val  Ile Val Glu Lys Asp  Arg Glu Lys 
    1520                 1525                 1530             


Thr Gly  Asp Thr Ser Arg Met  Phe Arg Arg Thr Lys  Ser Tyr Asp 
    1535                 1540                 1545             


Ser Leu  Leu Thr Thr Leu Ile  Gly Ala Gly Ile Arg  Ile Leu Phe 
    1550                 1555                 1560             


Ser Ser  Cys Gln Glu Glu Thr  Ala Asp Leu Leu Lys  Glu Leu Ser 
    1565                 1570                 1575             


Leu Val  Glu Gln Arg Lys Asn  Val Gly Ile His Val  Pro Thr Val 
    1580                 1585                 1590             


Val Asn  Ser Asn Lys Ser Glu  Ala Leu Gln Phe Tyr  Leu Ser Ile 
    1595                 1600                 1605             


Pro Asn  Ile Ser Tyr Ile Thr  Ala Leu Asn Met Cys  His Gln Phe 
    1610                 1615                 1620             


Ser Ser  Val Lys Arg Met Ala  Asn Ser Ser Leu Gln  Glu Ile Ser 
    1625                 1630                 1635             


Met Tyr  Ala Gln Val Thr His  Gln Lys Ala Glu Glu  Ile Tyr Arg 
    1640                 1645                 1650             


Tyr Ile  His Tyr Val Phe Asp  Ile Gln Met Leu Pro  Asn Asp Leu 
    1655                 1660                 1665             


Asn Gln  Asp Arg Leu Lys Ser  Asp Ile 
    1670                 1675         


<210>  27
<211>  1940
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein delta ERCC4

<400>  27

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Thr  Thr Leu Ile 
    1805                 1810                 1815             


Gly Ala  Gly Ile Arg Ile Leu  Phe Ser Ser Cys Gln  Glu Glu Thr 
    1820                 1825                 1830             


Ala Asp  Leu Leu Lys Glu Leu  Ser Leu Val Glu Gln  Arg Lys Asn 
    1835                 1840                 1845             


Val Gly  Ile His Val Pro Thr  Val Val Asn Ser Asn  Lys Ser Glu 
    1850                 1855                 1860             


Ala Leu  Gln Phe Tyr Leu Ser  Ile Pro Asn Ile Ser  Tyr Ile Thr 
    1865                 1870                 1875             


Ala Leu  Asn Met Cys His Gln  Phe Ser Ser Val Lys  Arg Met Ala 
    1880                 1885                 1890             


Asn Ser  Ser Leu Gln Glu Ile  Ser Met Tyr Ala Gln  Val Thr His 
    1895                 1900                 1905             


Gln Lys  Ala Glu Glu Ile Tyr  Arg Tyr Ile His Tyr  Val Phe Asp 
    1910                 1915                 1920             


Ile Gln  Met Leu Pro Asn Asp  Leu Asn Gln Asp Arg  Leu Lys Ser 
    1925                 1930                 1935             


Asp Ile  
    1940 


<210>  28
<211>  1970
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant FANCM protein delta HhH

<400>  28

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Phe Asp 
    1220                 1225                 1230             


Leu Gly  Phe Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  
    1970 


<210>  29
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wildtype FANCM MM2 peptide

<400>  29

Glu Asp Ile Phe Asp Cys Ser Arg Asp Leu Phe Ser Val Thr Phe Asp 
1               5                   10                  15      


Leu Gly Phe Cys Ser Pro Asp Ser Asp Asp Glu Ile Leu Glu His Thr 
            20                  25                  30          


Ser Asp 
        


<210>  30
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated FANCM peptide

<400>  30

Glu Asp Ile Phe Asp Cys Ser Arg Asp Leu Phe Ser Val Thr Ala Asp 
1               5                   10                  15      


Leu Gly Ala Cys Ser Pro Asp Ser Asp Asp Glu Ile Leu Glu His Thr 
            20                  25                  30          


Ser Asp 
        


<210>  31
<211>  2022
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Lys Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Ala Val Gln Gln Val Ile Thr Asn Leu Leu Ile Gly Gln 
225                 230                 235                 240 


Ile Glu Leu Arg Ser Glu Asp Ser Pro Asp Ile Leu Thr Tyr Ser His 
                245                 250                 255     


Glu Arg Lys Val Glu Lys Leu Ile Val Pro Leu Gly Glu Glu Leu Ala 
            260                 265                 270         


Ala Ile Gln Lys Thr Tyr Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser 
        275                 280                 285             


Leu Ile Gln Arg Asn Val Leu Met Arg Arg Asp Ile Pro Asn Leu Thr 
    290                 295                 300                 


Lys Tyr Gln Ile Ile Leu Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser 
305                 310                 315                 320 


Pro Asn Ile Val Gly Ile Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala 
                325                 330                 335     


Ile Cys Ile Ser Leu Tyr His Gly Tyr Glu Leu Leu Gln Gln Met Gly 
            340                 345                 350         


Met Arg Ser Leu Tyr Phe Phe Leu Cys Gly Ile Met Asp Gly Thr Lys 
        355                 360                 365             


Gly Met Thr Arg Ser Lys Asn Glu Leu Gly Arg Asn Glu Asp Phe Met 
    370                 375                 380                 


Lys Leu Tyr Asn His Leu Glu Cys Met Phe Ala Arg Thr Arg Ser Thr 
385                 390                 395                 400 


Ser Ala Asn Gly Ile Ser Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys 
                405                 410                 415     


Phe Val Tyr Ser His Pro Lys Leu Lys Lys Leu Glu Glu Val Val Ile 
            420                 425                 430         


Glu His Phe Lys Ser Trp Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg 
        435                 440                 445             


Asp Glu Thr Arg Val Met Ile Phe Ser Ser Phe Arg Asp Ser Val Gln 
    450                 455                 460                 


Glu Ile Ala Glu Met Leu Ser Gln His Gln Pro Ile Ile Arg Val Met 
465                 470                 475                 480 


Thr Phe Val Gly His Ala Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln 
                485                 490                 495     


Lys Glu Gln Leu Glu Val Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn 
            500                 505                 510         


Thr Leu Val Ser Thr Cys Val Gly Glu Glu Gly Leu Asp Ile Gly Glu 
        515                 520                 525             


Val Asp Leu Ile Ile Cys Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu 
    530                 535                 540                 


Val Gln Arg Met Gly Arg Thr Gly Arg Lys Arg Gln Gly Arg Ile Val 
545                 550                 555                 560 


Ile Ile Leu Ser Glu Gly Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln 
                565                 570                 575     


Ser Asn Lys Arg Ser Ile Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val 
            580                 585                 590         


Leu His Phe Tyr Gln Arg Ser Pro Arg Met Val Pro Asp Gly Ile Asn 
        595                 600                 605             


Pro Lys Leu His Lys Met Phe Ile Thr His Gly Val Tyr Glu Pro Glu 
    610                 615                 620                 


Lys Pro Ser Arg Asn Leu Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg 
625                 630                 635                 640 


Asp Gly Met Arg Gln Ser Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu 
                645                 650                 655     


Glu Glu Phe Lys Leu Trp Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp 
            660                 665                 670         


Glu Ile Lys Glu Ile Thr Leu Pro Gln Val Gln Phe Ser Ser Leu Gln 
        675                 680                 685             


Asn Glu Glu Asn Lys Pro Ala Gln Glu Ser Thr Thr Gly Ile His Gln 
    690                 695                 700                 


Leu Ser Leu Ser Glu Trp Arg Leu Trp Gln Asp His Pro Leu Pro Thr 
705                 710                 715                 720 


His Gln Val Asp His Ser Asp Arg Cys Arg His Phe Ile Gly Leu Met 
                725                 730                 735     


Gln Met Ile Glu Gly Met Arg His Glu Glu Gly Glu Cys Ser Tyr Glu 
            740                 745                 750         


Leu Glu Val Glu Ser Tyr Leu Gln Met Glu Asp Val Thr Ser Thr Phe 
        755                 760                 765             


Ile Ala Pro Arg Asn Glu Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile 
    770                 775                 780                 


Thr His Lys Lys Ser Ser Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser 
785                 790                 795                 800 


Ser Ser Val Ile Glu Ser Asp Glu Glu Cys Ala Glu Ile Val Lys Gln 
                805                 810                 815     


Thr His Ile Lys Pro Thr Lys Ile Val Ser Leu Lys Lys Lys Val Ser 
            820                 825                 830         


Lys Glu Ile Lys Lys Asp Gln Leu Lys Lys Glu Asn Asn His Gly Ile 
        835                 840                 845             


Ile Asp Ser Val Asp Asn Asp Arg Asn Ser Thr Val Glu Asn Ile Phe 
    850                 855                 860                 


Gln Glu Asp Leu Pro Asn Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile 
865                 870                 875                 880 


Ala Ala Thr Cys Thr Ile Asn Glu Asn Val Ile Lys Glu Pro Cys Val 
                885                 890                 895     


Leu Leu Thr Glu Cys Gln Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala 
            900                 905                 910         


Gly Asn Val Leu Asp Ser Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser 
        915                 920                 925             


Val Ser Ser Asn Leu Phe Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val 
    930                 935                 940                 


Arg Thr Asp Asp Gln Phe Tyr Asn Cys His Ser Leu Thr Lys Glu Val 
945                 950                 955                 960 


Leu Ala Asn Val Glu Arg Phe Leu Ser Tyr Ser Pro Pro Pro Leu Ser 
                965                 970                 975     


Gly Leu Ser Asp Leu Glu Tyr Glu Ile Ala Lys Gly Thr Ala Leu Glu 
            980                 985                 990         


Asn Leu Leu Phe Leu Pro Cys Ala  Glu His Leu Arg Ser  Asp Lys Cys 
        995                 1000                 1005             


Thr Cys  Leu Leu Ser His Ser  Ala Val Asn Ser Gln  Gln Asn Leu 
    1010                 1015                 1020             


Glu Leu  Asn Ser Leu Lys Cys  Ile Asn Tyr Pro Ser  Glu Lys Ser 
    1025                 1030                 1035             


Cys Leu  Tyr Asp Ile Pro Asn  Asp Asn Ile Ser Asp  Glu Pro Ser 
    1040                 1045                 1050             


Leu Cys  Asp Cys Asp Val His  Lys His Asn Gln Asn  Glu Asn Leu 
    1055                 1060                 1065             


Val Pro  Asn Asn Arg Val Gln  Ile His Arg Ser Pro  Ala Gln Asn 
    1070                 1075                 1080             


Leu Val  Gly Glu Asn Asn His  Asp Val Asp Asn Ser  Asp Leu Pro 
    1085                 1090                 1095             


Val Leu  Ser Thr Asp Gln Asp  Glu Ser Leu Leu Leu  Phe Glu Asp 
    1100                 1105                 1110             


Val Asn  Thr Glu Phe Asp Asp  Val Ser Leu Ser Pro  Leu Asn Ser 
    1115                 1120                 1125             


Lys Ser  Glu Ser Leu Pro Val  Ser Asp Lys Thr Ala  Ile Ser Glu 
    1130                 1135                 1140             


Thr Pro  Leu Val Ser Gln Phe  Leu Ile Ser Asp Glu  Leu Leu Leu 
    1145                 1150                 1155             


Asp Asn  Asn Ser Glu Leu Gln  Asp Gln Ile Thr Arg  Asp Ala Asn 
    1160                 1165                 1170             


Ser Phe  Lys Ser Arg Asp Gln  Arg Gly Val Gln Glu  Glu Lys Val 
    1175                 1180                 1185             


Lys Asn  His Glu Asp Ile Phe  Asp Cys Ser Arg Asp  Leu Phe Ser 
    1190                 1195                 1200             


Val Thr  Phe Asp Leu Gly Phe  Cys Ser Pro Asp Ser  Asp Asp Glu 
    1205                 1210                 1215             


Ile Leu  Glu His Thr Ser Asp  Ser Asn Arg Pro Leu  Asp Asp Leu 
    1220                 1225                 1230             


Tyr Gly  Arg Tyr Leu Glu Ile  Lys Glu Ile Ser Asp  Ala Asn Tyr 
    1235                 1240                 1245             


Val Ser  Asn Gln Ala Leu Ile  Pro Arg Asp His Ser  Lys Asn Phe 
    1250                 1255                 1260             


Thr Ser  Gly Thr Val Ile Ile  Pro Ser Asn Glu Asp  Met Gln Asn 
    1265                 1270                 1275             


Pro Asn  Tyr Val His Leu Pro  Leu Ser Ala Ala Lys  Asn Glu Glu 
    1280                 1285                 1290             


Leu Leu  Ser Pro Gly Tyr Ser  Gln Phe Ser Leu Pro  Val Gln Lys 
    1295                 1300                 1305             


Lys Val  Met Ser Thr Pro Leu  Ser Lys Ser Asn Thr  Leu Asn Ser 
    1310                 1315                 1320             


Phe Ser  Lys Ile Arg Lys Glu  Ile Leu Lys Thr Pro  Asp Ser Ser 
    1325                 1330                 1335             


Lys Glu  Lys Val Asn Leu Gln  Arg Phe Lys Glu Ala  Leu Asn Ser 
    1340                 1345                 1350             


Thr Phe  Asp Tyr Ser Glu Phe  Ser Leu Glu Lys Ser  Lys Ser Ser 
    1355                 1360                 1365             


Gly Pro  Met Tyr Leu His Lys  Ser Cys His Ser Val  Glu Asp Gly 
    1370                 1375                 1380             


Gln Leu  Leu Thr Ser Asn Glu  Ser Glu Asp Asp Glu  Ile Phe Arg 
    1385                 1390                 1395             


Arg Lys  Val Lys Arg Ala Lys  Gly Asn Val Leu Asn  Ser Pro Glu 
    1400                 1405                 1410             


Asp Gln  Lys Asn Ser Glu Val  Asp Ser Pro Leu His  Ala Val Lys 
    1415                 1420                 1425             


Lys Arg  Arg Phe Pro Ile Asn  Arg Ser Glu Leu Ser  Ser Ser Asp 
    1430                 1435                 1440             


Glu Ser  Glu Asn Phe Pro Lys  Pro Cys Ser Gln Leu  Glu Asp Phe 
    1445                 1450                 1455             


Lys Val  Cys Asn Gly Asn Ala  Arg Arg Gly Ile Lys  Val Pro Lys 
    1460                 1465                 1470             


Arg Gln  Ser His Leu Lys His  Val Ala Arg Lys Phe  Leu Asp Asp 
    1475                 1480                 1485             


Glu Ala  Glu Leu Ser Glu Glu  Asp Ala Glu Tyr Val  Ser Ser Asp 
    1490                 1495                 1500             


Glu Asn  Asp Glu Ser Glu Asn  Glu Gln Asp Ser Ser  Leu Leu Asp 
    1505                 1510                 1515             


Phe Leu  Asn Asp Glu Thr Gln  Leu Ser Gln Ala Ile  Asn Asp Ser 
    1520                 1525                 1530             


Glu Met  Arg Ala Ile Tyr Met  Lys Ser Leu Arg Ser  Pro Met Met 
    1535                 1540                 1545             


Asn Asn  Lys Tyr Lys Met Ile  His Lys Thr His Lys  Asn Ile Asn 
    1550                 1555                 1560             


Ile Phe  Ser Gln Ile Pro Glu  Gln Asp Glu Thr Tyr  Leu Glu Asp 
    1565                 1570                 1575             


Ser Phe  Cys Val Asp Glu Glu  Glu Ser Cys Lys Gly  Gln Ser Ser 
    1580                 1585                 1590             


Glu Glu  Glu Val Cys Val Asp  Phe Asn Leu Ile Thr  Asp Asp Cys 
    1595                 1600                 1605             


Phe Ala  Asn Ser Lys Lys Tyr  Lys Thr Arg Arg Ala  Val Met Leu 
    1610                 1615                 1620             


Lys Glu  Met Met Glu Gln Asn  Cys Ala His Ser Lys  Lys Lys Leu 
    1625                 1630                 1635             


Ser Arg  Ile Ile Leu Pro Asp  Asp Ser Ser Glu Glu  Glu Asn Asn 
    1640                 1645                 1650             


Val Asn  Asp Lys Arg Glu Ser  Asn Ile Ala Val Asn  Pro Ser Thr 
    1655                 1660                 1665             


Val Lys  Lys Asn Lys Gln Gln  Asp His Cys Leu Asn  Ser Val Pro 
    1670                 1675                 1680             


Ser Gly  Ser Ser Ala Gln Ser  Lys Val Arg Ser Thr  Pro Arg Val 
    1685                 1690                 1695             


Asn Pro  Leu Ala Lys Gln Ser  Lys Gln Thr Ser Leu  Asn Leu Lys 
    1700                 1705                 1710             


Asp Thr  Ile Ser Glu Val Ser  Asp Phe Lys Pro Gln  Asn His Asn 
    1715                 1720                 1725             


Glu Val  Gln Ser Thr Thr Pro  Pro Phe Thr Thr Val  Asp Ser Gln 
    1730                 1735                 1740             


Lys Asp  Cys Arg Lys Phe Pro  Val Pro Gln Lys Asp  Gly Ser Ala 
    1745                 1750                 1755             


Leu Glu  Asp Ser Ser Thr Ser  Gly Ala Ser Cys Ser  Lys Ser Arg 
    1760                 1765                 1770             


Pro His  Leu Ala Gly Thr His  Thr Ser Leu Arg Leu  Pro Gln Glu 
    1775                 1780                 1785             


Gly Lys  Gly Thr Cys Ile Leu  Val Gly Gly His Glu  Ile Thr Ser 
    1790                 1795                 1800             


Gly Leu  Glu Val Ile Ser Ser  Leu Arg Ala Ile His  Gly Leu Gln 
    1805                 1810                 1815             


Val Glu  Val Cys Pro Leu Asn  Gly Cys Asp Tyr Ile  Val Ser Asn 
    1820                 1825                 1830             


Arg Met  Val Val Glu Arg Arg  Ser Gln Ser Glu Met  Leu Asn Ser 
    1835                 1840                 1845             


Val Asn  Lys Asn Lys Phe Ile  Glu Gln Ile Gln His  Leu Gln Ser 
    1850                 1855                 1860             


Met Phe  Glu Arg Ile Cys Val  Ile Val Glu Lys Asp  Arg Glu Lys 
    1865                 1870                 1875             


Thr Gly  Asp Thr Ser Arg Met  Phe Arg Arg Thr Lys  Ser Tyr Asp 
    1880                 1885                 1890             


Ser Leu  Leu Thr Thr Leu Ile  Gly Ala Gly Ile Arg  Ile Leu Phe 
    1895                 1900                 1905             


Ser Ser  Cys Gln Glu Glu Thr  Ala Asp Leu Leu Lys  Glu Leu Ser 
    1910                 1915                 1920             


Leu Val  Glu Gln Arg Lys Asn  Val Gly Ile His Val  Pro Thr Val 
    1925                 1930                 1935             


Val Asn  Ser Asn Lys Ser Glu  Ala Leu Gln Phe Tyr  Leu Ser Ile 
    1940                 1945                 1950             


Pro Asn  Ile Ser Tyr Ile Thr  Ala Leu Asn Met Cys  His Gln Phe 
    1955                 1960                 1965             


Ser Ser  Val Lys Arg Met Ala  Asn Ser Ser Leu Gln  Glu Ile Ser 
    1970                 1975                 1980             


Met Tyr  Ala Gln Val Thr His  Gln Lys Ala Glu Glu  Ile Tyr Arg 
    1985                 1990                 1995             


Tyr Ile  His Tyr Val Phe Asp  Ile Gln Met Leu Pro  Asn Asp Leu 
    2000                 2005                 2010             


Asn Gln  Asp Arg Leu Lys Ser  Asp Ile 
    2015                 2020         


<210>  32
<211>  7060
<212>  DNA
<213>  Homo sapiens

<400>  32
tgtgcgaagg aaaccgatgg ggatcggaac cgtagcggtt gagctgctgc tgctacggat       60

atctgacaga agccttcggt ggttgtcggc ctaatgagcg gacggcaaag aacgcttttt      120

cagacgtggg gctcaagtat ctcccgatca tctgggactc cgggttgcag ctccggaact      180

gagcgacctc agagccctgg cagctccaag gcgcctttgc cagcagcagc ggaggctcag      240

ctggagtcgg acgatgatgt gttgcttgtc gcggcgtacg aggctgagcg gcagttgtgt      300

ctagagaatg gcgggttctg cacctccgcg ggcgccctgt ggatttaccc taccaattgc      360

ccagtgcggg actaccagct gcacatttcc cgggctgctc tgttttgcaa tacgctggtg      420

tgtctgccta ccggactggg aaagaccttt attgccgccg tggtcatgta caatttctac      480

cgctggttcc cttcaggaaa ggtggtcttc atggccccaa cgaaaccctt ggtgacacag      540

cagatcgagg cttgctacca ggtgatgggt atcccgcaat cccacatggc cgaaatgaca      600

gggtctacac aagcttccac caggaaggaa atatggtgca gtaagagagt gctttttctt      660

acacctcagg tcatggtaaa tgacctttct agaggagctt gtcccgctgc tgaaataaag      720

tgtttagtta ttgatgaagc tcataaagct ctcggaaact atgcttattg ccaggctgtg      780

caacaagtta ttactaacct gctaattggg cagatagagc ttcgttctga agattctcca      840

gatattttga catattctca tgaaagaaaa gttgaaaagc ttattgttcc gcttggtgaa      900

gaacttgcag ccatccaaaa gacctatatc cagattttgg aatcatttgc tcgttctttg      960

attcagagga atgttttgat gagaagggat atcccaaatc taacaaaata tcagataatt     1020

ctggcaagag atcagtttag gaaaaaccca tctccgaata ttgtgggaat acaacaaggc     1080

ataatcgagg gagagtttgc tatttgtatt agtttatatc atggttatga attattgcag     1140

caaatgggaa tgagatcatt atatttcttc ctttgtggaa ttatggatgg aactaaaggg     1200

atgacacggt caaaaaatga acttggccga aatgaagact tcatgaaact ctataatcat     1260

ctagagtgta tgtttgcacg tacacgtagt acttcagcaa atggtatttc tgctatccaa     1320

caaggagata aaaataaaaa atttgtttat agtcatccaa agttaaagaa attagaagaa     1380

gttgtaattg aacacttcaa gtcatggaat gctgaaaaca ctactgaaaa gaaacgtgat     1440

gagacccgag ttatgatctt ctcttcattt cgagatagtg ttcaagaaat tgcagaaatg     1500

ctttcacagc atcagccaat tattagagta atgacttttg tcggccatgc ctcagggaaa     1560

agcacgaagg gttttaccca gaaggagcaa ctggaggtag tgaaacagtt tcgtgacggt     1620

ggttacaaca cgctggtttc tacctgtgtg ggtgaagaag gtttggatat aggagaagtt     1680

gatcttataa tatgttttga ttcccagaag agcccaattc gtcttgtaca acgaatgggt     1740

agaactggcc gtaaacgtca aggcaggata gttattatcc tttctgaagg acgagaggaa     1800

cgtatttata atcagagtca gtccaacaaa agaagtatat ataaagctat ttcaagtaac     1860

aggcaggtcc ttcattttta ccaaagaagt ccacgaatgg ttcctgatgg aatcaaccca     1920

aaattacaca aaatgttcat cacacatggt gtctatgaac cagagaagcc ttctcggaac     1980

ttgcagcgaa agtcatctat cttttcctat agggatggaa tgaggcaaag tagcctaaag     2040

aaagattggt tcttatcaga agaagaattt aaattatgga acagacttta tagattaagg     2100

gacagtgatg aaattaaaga gataacattg cctcaagttc agttttcttc tttacaaaat     2160

gaggaaaaca aaccagctca agaatcaacc actggaattc atcaactctc tctctctgaa     2220

tggagactgt ggcaagatca tcctttgcct acacatcaag ttgatcactc agatcgatgc     2280

cgccatttta taggccttat gcaaatgata gagggaatga gacacgaaga gggagaatgc     2340

agctatgaat tggaagttga atcttattta caaatggaag atgttacctc aacatttatt     2400

gctcccagga atgaatctaa taatcttgcc agtgacacct ttatcactca caagaaatcg     2460

tcatttataa agaacataaa tcaaggcagt tcatcctcag tgatagaatc tgatgaagaa     2520

tgtgctgaaa ttgttaaaca aactcatatc aaacctacta aaattgtttc tttaaagaaa     2580

aaagtgtcta aagaaataaa aaaagatcag cttaaaaaag aaaataatca cggtattata     2640

gattctgtag ataatgacag aaattccact gttgaaaata tttttcaaga agacctacca     2700

aatgataaaa ggacatcaga tacagatgaa attgctgcca catgtactat taatgaaaat     2760

gttattaaag aaccgtgtgt gttattaaca gagtgtcagt ttacaaataa atccactagt     2820

tcacttgctg gaaatgtttt agattctggt tataacagtt tcaatgatga aaaatctgtt     2880

tcatctaact tatttcttcc attcgaagaa gagctttata ttgttagaac agatgaccaa     2940

ttttataatt gtcactcatt gacaaaagag gtactagcta atgtagagag atttttatct     3000

tattctcctc cgcctctcag tggactctca gacttggaat atgaaattgc taagggtact     3060

gcacttgaga atttgctttt cttaccctgt gcagagcatt tacgaagtga taaatgcacc     3120

tgtttgctgt cacattcagc tgtgaattct caacagaatt tagaattgaa ttcacttaaa     3180

tgtataaatt atccatctga aaaaagttgc ctttatgata tacctaatga taatatttct     3240

gatgagccaa gtctctgtga ctgtgatgta cataaacata atcaaaatga aaatttagta     3300

cctaacaatc gtgttcaaat acacagaagc cctgcacaga atttagttgg agagaacaat     3360

catgatgttg ataacagtga cctcccagta ttgtccactg atcaagatga aagtttgctg     3420

ttatttgaag atgttaatac agagttcgac gatgtgagtc tttcaccctt gaacagtaaa     3480

agcgaatctt tacctgtgtc agacaaaact gctattagtg aaacgcctct ggtctctcag     3540

ttcttaattt ctgatgaact tttgttggac aataattctg aactccaaga tcaaatcacc     3600

cgtgatgcta atagttttaa atctcgtgat cagagaggtg tacaggaaga aaaagtgaag     3660

aatcatgagg atatttttga ttgctctagg gatttatttt ctgttacctt tgatttagga     3720

ttctgtagtc cagattctga tgatgaaata ttggaacata catcagatag caatagacct     3780

ctagatgatc tatatggaag gtatttggaa attaaggaga taagtgatgc aaattatgtt     3840

tcgaatcaag cactaatacc aagagatcat agtaaaaatt ttactagtgg aactgttatt     3900

atcccatcaa atgaagatat gcagaatcca aattatgtac atttgccact gagtgcagca     3960

aaaaatgaag aattgttatc tcctggttat tctcagtttt ctttaccagt gcaaaaaaaa     4020

gttatgagta caccactctc taaatcaaac acattgaact cattttctaa gataagaaag     4080

gaaatactta agacaccaga ttctagtaag gaaaaagtaa acctacaaag attcaaagaa     4140

gcattgaatt caacttttga ttattcagaa ttttctctag aaaagtctaa aagcagtggt     4200

ccaatgtatc tgcataaatc ctgtcattct gttgaagatg gacaattatt aacaagtaac     4260

gaaagtgaag atgacgagat tttccgaaga aaagttaaaa gagcaaaagg aaatgtttta     4320

aactctcctg aggatcagaa aaatagtgaa gttgattctc cacttcatgc tgtcaaaaag     4380

cgcagatttc ctataaacag atcagaatta tcatctagtg atgagagtga gaattttccc     4440

aaaccatgtt cacaattaga agacttcaag gtttgtaacg ggaatgccag aagaggcatc     4500

aaagtcccaa agagacagag tcacttaaag catgtagcta ggaagttttt agatgatgaa     4560

gcagaacttt ctgaagaaga tgcagaatat gtttcatcag atgaaaatga tgagtcagaa     4620

aatgaacaag attcctcatt acttgacttt ttaaatgatg aaactcaact ttcacaggct     4680

ataaatgatt ctgaaatgag agctatttac atgaaatctt tgcgtagtcc aatgatgaac     4740

aataagtaca aaatgattca taagacacat aaaaacataa acattttctc gcagattcct     4800

gaacaagatg aaacctattt agaggatagt ttttgtgttg atgaagagga gtcttgcaaa     4860

ggccaatcaa gtgaagaaga agtttgtgtt gattttaact taataactga tgattgcttt     4920

gcaaatagta aaaagtataa aactcgacgt gcagtaatgc taaaagaaat gatggaacaa     4980

aattgtgcac attcaaaaaa gaaattatcc agaattattt taccagatga ttcaagtgag     5040

gaggagaaca atgtaaatga taaaagagaa tctaatattg cggttaaccc aagcactgtt     5100

aagaagaaca aacaacagga ccattgttta aattcagtgc cttctggatc ttctgcgcag     5160

tccaaggtgc gttctactcc aagagttaat ccattagcaa agcagagcaa acagacatcg     5220

ctgaatttaa aggatacaat ttccgaagtc tcagacttca aacctcagaa tcataatgaa     5280

gtccagtcta ccacaccacc cttcactact gttgattcac agaaagactg tagaaaattt     5340

ccagttccac agaaggatgg tagtgctttg gaggattcta gcacttcagg ggcatcctgt     5400

tccaagtcaa gaccacattt agctgggaca catacttctc ttagacttcc gcaggaagga     5460

aaaggaacct gtattcttgt aggtggtcat gaaatcactt ctggattaga agtaatttct     5520

tccctaagag caattcatgg gttgcaagta gaagtttgtc ctcttaatgg ctgtgattac     5580

atcgtgagta atcgcatggt ggtggaaagg aggtctcaat ctgagatgtt aaatagtgtc     5640

aataagaaca agttcattga gcagatccag cacctgcaga gtatgtttga aagaatatgt     5700

gtgattgtgg aaaaggacag agaaaaaaca ggagacacat caaggatgtt taggagaaca     5760

aagagctatg acagcctgct gactacctta attggcgctg gaatccgaat tcttttcagt     5820

tcctgccaag aagaaaccgc agatttgcta aaggaactgt ctttagtgga acaaagaaag     5880

aatgttggta ttcatgttcc aacagtggtg aatagtaata aaagtgaggc actccagttt     5940

tatttaagta ttcccaatat aagttatata actgcattaa atatgtgtca ccagttttca     6000

tctgtgaaaa ggatggctaa cagctcactt caagaaatct ccatgtatgc acaagtaact     6060

catcagaagg ctgaggagat ctatagatat attcactatg tatttgacat acaaatgtta     6120

ccaaatgatc ttaaccaaga tagactgaaa tctgatatat aatcaagctg ctcaagatgg     6180

ggttttcaaa gacctctcac aatattaaat gcacttcaat aatcattgct gttttatgtt     6240

tatttgtaaa taagagaata ttttatttaa atattttata ttgtatacat ttttatttat     6300

agattataga aattattaaa aaagaaaaat ctgatgttca gtgatcattt tgactagatt     6360

ataaaactaa tttttcttat taaataaaac aaggtttatt aaaagtgtta ctaaggatag     6420

tttaagaaag taaaagctaa gctagagata tactttggaa tgtttcccaa aattaaagtt     6480

gtactgttgt gataaatagt aaagttgaca tgtctatgac tacagccaac ttgtcgattt     6540

tccctatgtg tagatagtat acttttaagt gtactgattc taaatacatg tacttggtaa     6600

ggtgtgggtg atgggtgggt tgtgagataa atgacccagt aactaggaaa gtagaaaact     6660

taactgaatg tttatctgac caaaggtgtg tcccagttaa gtactgtcaa atctattaat     6720

atgaactctg atatggtttg gctgtgtccc caaccaaaat ctcatcttga cttgtaatct     6780

gaattataat cccaatatat tggggaggga cctcctggaa cgtgattagc tcatgggggc     6840

ggttccccca tgctgttcta gtgatagttc tcagaggatc tgatggtttt ataagctttt     6900

cctctgttca ctctgcagtt ctcttgccta ctgccatgtg gaaaaggaaa cgtttgcttc     6960

ccctccacca tgattgtaag ttcccgaggc ctccccagcc atgcaggact gtgagtcaat     7020

taaacatctt ttccttataa attaaaaaaa aaaaaaaaaa                           7060


<210>  33
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siFa

<400>  33
ggatgtttag gagaacaaag agcta                                             25


<210>  34
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siFb

<400>  34
cccatcaaat gaagatatgc agaat                                             25


<210>  35
<211>  2048
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized mutant

<400>  35

Met Ser Gly Arg Gln Arg Thr Leu Phe Gln Thr Trp Gly Ser Ser Ile 
1               5                   10                  15      


Ser Arg Ser Ser Gly Thr Pro Gly Cys Ser Ser Gly Thr Glu Arg Pro 
            20                  25                  30          


Gln Ser Pro Gly Ser Ser Lys Ala Pro Leu Pro Ala Ala Ala Glu Ala 
        35                  40                  45              


Gln Leu Glu Ser Asp Asp Asp Val Leu Leu Val Ala Ala Tyr Glu Ala 
    50                  55                  60                  


Glu Arg Gln Leu Cys Leu Glu Asn Gly Gly Phe Cys Thr Ser Ala Gly 
65                  70                  75                  80  


Ala Leu Trp Ile Tyr Pro Thr Asn Cys Pro Val Arg Asp Tyr Gln Leu 
                85                  90                  95      


His Ile Ser Arg Ala Ala Leu Phe Cys Asn Thr Leu Val Cys Leu Pro 
            100                 105                 110         


Thr Gly Leu Gly Arg Thr Phe Ile Ala Ala Val Val Met Tyr Asn Phe 
        115                 120                 125             


Tyr Arg Trp Phe Pro Ser Gly Lys Val Val Phe Met Ala Pro Thr Lys 
    130                 135                 140                 


Pro Leu Val Thr Gln Gln Ile Glu Ala Cys Tyr Gln Val Met Gly Ile 
145                 150                 155                 160 


Pro Gln Ser His Met Ala Glu Met Thr Gly Ser Thr Gln Ala Ser Thr 
                165                 170                 175     


Arg Lys Glu Ile Trp Cys Ser Lys Arg Val Leu Phe Leu Thr Pro Gln 
            180                 185                 190         


Val Met Val Asn Asp Leu Ser Arg Gly Ala Cys Pro Ala Ala Glu Ile 
        195                 200                 205             


Lys Cys Leu Val Ile Asp Glu Ala His Lys Ala Leu Gly Asn Tyr Ala 
    210                 215                 220                 


Tyr Cys Gln Val Val Arg Glu Leu Val Lys Tyr Thr Asn His Phe Arg 
225                 230                 235                 240 


Ile Leu Ala Leu Ser Ala Thr Pro Gly Ser Asp Ile Lys Ala Val Gln 
                245                 250                 255     


Gln Val Ile Thr Asn Leu Leu Ile Gly Gln Ile Glu Leu Arg Ser Glu 
            260                 265                 270         


Asp Ser Pro Asp Ile Leu Thr Tyr Ser His Glu Arg Lys Val Glu Lys 
        275                 280                 285             


Leu Ile Val Pro Leu Gly Glu Glu Leu Ala Ala Ile Gln Lys Thr Tyr 
    290                 295                 300                 


Ile Gln Ile Leu Glu Ser Phe Ala Arg Ser Leu Ile Gln Arg Asn Val 
305                 310                 315                 320 


Leu Met Arg Arg Asp Ile Pro Asn Leu Thr Lys Tyr Gln Ile Ile Leu 
                325                 330                 335     


Ala Arg Asp Gln Phe Arg Lys Asn Pro Ser Pro Asn Ile Val Gly Ile 
            340                 345                 350         


Gln Gln Gly Ile Ile Glu Gly Glu Phe Ala Ile Cys Ile Ser Leu Tyr 
        355                 360                 365             


His Gly Tyr Glu Leu Leu Gln Gln Met Gly Met Arg Ser Leu Tyr Phe 
    370                 375                 380                 


Phe Leu Cys Gly Ile Met Asp Gly Thr Lys Gly Met Thr Arg Ser Lys 
385                 390                 395                 400 


Asn Glu Leu Gly Arg Asn Glu Asp Phe Met Lys Leu Tyr Asn His Leu 
                405                 410                 415     


Glu Cys Met Phe Ala Arg Thr Arg Ser Thr Ser Ala Asn Gly Ile Ser 
            420                 425                 430         


Ala Ile Gln Gln Gly Asp Lys Asn Lys Lys Phe Val Tyr Ser His Pro 
        435                 440                 445             


Lys Leu Lys Lys Leu Glu Glu Val Val Ile Glu His Phe Lys Ser Trp 
    450                 455                 460                 


Asn Ala Glu Asn Thr Thr Glu Lys Lys Arg Asp Glu Thr Arg Val Met 
465                 470                 475                 480 


Ile Phe Ser Ser Phe Arg Asp Ser Val Gln Glu Ile Ala Glu Met Leu 
                485                 490                 495     


Ser Gln His Gln Pro Ile Ile Arg Val Met Thr Phe Val Gly His Ala 
            500                 505                 510         


Ser Gly Lys Ser Thr Lys Gly Phe Thr Gln Lys Glu Gln Leu Glu Val 
        515                 520                 525             


Val Lys Gln Phe Arg Asp Gly Gly Tyr Asn Thr Leu Val Ser Thr Cys 
    530                 535                 540                 


Val Gly Glu Glu Gly Leu Asp Ile Gly Glu Val Asp Leu Ile Ile Cys 
545                 550                 555                 560 


Phe Asp Ser Gln Lys Ser Pro Ile Arg Leu Val Gln Arg Met Gly Arg 
                565                 570                 575     


Thr Gly Arg Lys Arg Gln Gly Arg Ile Val Ile Ile Leu Ser Glu Gly 
            580                 585                 590         


Arg Glu Glu Arg Ile Tyr Asn Gln Ser Gln Ser Asn Lys Arg Ser Ile 
        595                 600                 605             


Tyr Lys Ala Ile Ser Ser Asn Arg Gln Val Leu His Phe Tyr Gln Arg 
    610                 615                 620                 


Ser Pro Arg Met Val Pro Asp Gly Ile Asn Pro Lys Leu His Lys Met 
625                 630                 635                 640 


Phe Ile Thr His Gly Val Tyr Glu Pro Glu Lys Pro Ser Arg Asn Leu 
                645                 650                 655     


Gln Arg Lys Ser Ser Ile Phe Ser Tyr Arg Asp Gly Met Arg Gln Ser 
            660                 665                 670         


Ser Leu Lys Lys Asp Trp Phe Leu Ser Glu Glu Glu Phe Lys Leu Trp 
        675                 680                 685             


Asn Arg Leu Tyr Arg Leu Arg Asp Ser Asp Glu Ile Lys Glu Ile Thr 
    690                 695                 700                 


Leu Pro Gln Val Gln Phe Ser Ser Leu Gln Asn Glu Glu Asn Lys Pro 
705                 710                 715                 720 


Ala Gln Glu Ser Thr Thr Gly Ile His Gln Leu Ser Leu Ser Glu Trp 
                725                 730                 735     


Arg Leu Trp Gln Asp His Pro Leu Pro Thr His Gln Val Asp His Ser 
            740                 745                 750         


Asp Arg Cys Arg His Phe Ile Gly Leu Met Gln Met Ile Glu Gly Met 
        755                 760                 765             


Arg His Glu Glu Gly Glu Cys Ser Tyr Glu Leu Glu Val Glu Ser Tyr 
    770                 775                 780                 


Leu Gln Met Glu Asp Val Thr Ser Thr Phe Ile Ala Pro Arg Asn Glu 
785                 790                 795                 800 


Ser Asn Asn Leu Ala Ser Asp Thr Phe Ile Thr His Lys Lys Ser Ser 
                805                 810                 815     


Phe Ile Lys Asn Ile Asn Gln Gly Ser Ser Ser Ser Val Ile Glu Ser 
            820                 825                 830         


Asp Glu Glu Cys Ala Glu Ile Val Lys Gln Thr His Ile Lys Pro Thr 
        835                 840                 845             


Lys Ile Val Ser Leu Lys Lys Lys Val Ser Lys Glu Ile Lys Lys Asp 
    850                 855                 860                 


Gln Leu Lys Lys Glu Asn Asn His Gly Ile Ile Asp Ser Val Asp Asn 
865                 870                 875                 880 


Asp Arg Asn Ser Thr Val Glu Asn Ile Phe Gln Glu Asp Leu Pro Asn 
                885                 890                 895     


Asp Lys Arg Thr Ser Asp Thr Asp Glu Ile Ala Ala Thr Cys Thr Ile 
            900                 905                 910         


Asn Glu Asn Val Ile Lys Glu Pro Cys Val Leu Leu Thr Glu Cys Gln 
        915                 920                 925             


Phe Thr Asn Lys Ser Thr Ser Ser Leu Ala Gly Asn Val Leu Asp Ser 
    930                 935                 940                 


Gly Tyr Asn Ser Phe Asn Asp Glu Lys Ser Val Ser Ser Asn Leu Phe 
945                 950                 955                 960 


Leu Pro Phe Glu Glu Glu Leu Tyr Ile Val Arg Thr Asp Asp Gln Phe 
                965                 970                 975     


Tyr Asn Cys His Ser Leu Thr Lys Glu Val Leu Ala Asn Val Glu Arg 
            980                 985                 990         


Phe Leu Ser Tyr Ser Pro Pro Pro  Leu Ser Gly Leu Ser  Asp Leu Glu 
        995                 1000                 1005             


Tyr Glu  Ile Ala Lys Gly Thr  Ala Leu Glu Asn Leu  Leu Phe Leu 
    1010                 1015                 1020             


Pro Cys  Ala Glu His Leu Arg  Ser Asp Lys Cys Thr  Cys Leu Leu 
    1025                 1030                 1035             


Ser His  Ser Ala Val Asn Ser  Gln Gln Asn Leu Glu  Leu Asn Ser 
    1040                 1045                 1050             


Leu Lys  Cys Ile Asn Tyr Pro  Ser Glu Lys Ser Cys  Leu Tyr Asp 
    1055                 1060                 1065             


Ile Pro  Asn Asp Asn Ile Ser  Asp Glu Pro Ser Leu  Cys Asp Cys 
    1070                 1075                 1080             


Asp Val  His Lys His Asn Gln  Asn Glu Asn Leu Val  Pro Asn Asn 
    1085                 1090                 1095             


Arg Val  Gln Ile His Arg Ser  Pro Ala Gln Asn Leu  Val Gly Glu 
    1100                 1105                 1110             


Asn Asn  His Asp Val Asp Asn  Ser Asp Leu Pro Val  Leu Ser Thr 
    1115                 1120                 1125             


Asp Gln  Asp Glu Ser Leu Leu  Leu Phe Glu Asp Val  Asn Thr Glu 
    1130                 1135                 1140             


Phe Asp  Asp Val Ser Leu Ser  Pro Leu Asn Ser Lys  Ser Glu Ser 
    1145                 1150                 1155             


Leu Pro  Val Ser Asp Lys Thr  Ala Ile Ser Glu Thr  Pro Leu Val 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ile Ser Asp  Glu Leu Leu Leu Asp  Asn Asn Ser 
    1175                 1180                 1185             


Glu Leu  Gln Asp Gln Ile Thr  Arg Asp Ala Asn Ser  Phe Lys Ser 
    1190                 1195                 1200             


Arg Asp  Gln Arg Gly Val Gln  Glu Glu Lys Val Lys  Asn His Glu 
    1205                 1210                 1215             


Asp Ile  Phe Asp Cys Ser Arg  Asp Leu Phe Ser Val  Thr Ala Asp 
    1220                 1225                 1230             


Leu Gly  Ala Cys Ser Pro Asp  Ser Asp Asp Glu Ile  Leu Glu His 
    1235                 1240                 1245             


Thr Ser  Asp Ser Asn Arg Pro  Leu Asp Asp Leu Tyr  Gly Arg Tyr 
    1250                 1255                 1260             


Leu Glu  Ile Lys Glu Ile Ser  Asp Ala Asn Tyr Val  Ser Asn Gln 
    1265                 1270                 1275             


Ala Leu  Ile Pro Arg Asp His  Ser Lys Asn Phe Thr  Ser Gly Thr 
    1280                 1285                 1290             


Val Ile  Ile Pro Ser Asn Glu  Asp Met Gln Asn Pro  Asn Tyr Val 
    1295                 1300                 1305             


His Leu  Pro Leu Ser Ala Ala  Lys Asn Glu Glu Leu  Leu Ser Pro 
    1310                 1315                 1320             


Gly Tyr  Ser Gln Phe Ser Leu  Pro Val Gln Lys Lys  Val Met Ser 
    1325                 1330                 1335             


Thr Pro  Leu Ser Lys Ser Asn  Thr Leu Asn Ser Phe  Ser Lys Ile 
    1340                 1345                 1350             


Arg Lys  Glu Ile Leu Lys Thr  Pro Asp Ser Ser Lys  Glu Lys Val 
    1355                 1360                 1365             


Asn Leu  Gln Arg Phe Lys Glu  Ala Leu Asn Ser Thr  Phe Asp Tyr 
    1370                 1375                 1380             


Ser Glu  Phe Ser Leu Glu Lys  Ser Lys Ser Ser Gly  Pro Met Tyr 
    1385                 1390                 1395             


Leu His  Lys Ser Cys His Ser  Val Glu Asp Gly Gln  Leu Leu Thr 
    1400                 1405                 1410             


Ser Asn  Glu Ser Glu Asp Asp  Glu Ile Phe Arg Arg  Lys Val Lys 
    1415                 1420                 1425             


Arg Ala  Lys Gly Asn Val Leu  Asn Ser Pro Glu Asp  Gln Lys Asn 
    1430                 1435                 1440             


Ser Glu  Val Asp Ser Pro Leu  His Ala Val Lys Lys  Arg Arg Phe 
    1445                 1450                 1455             


Pro Ile  Asn Arg Ser Glu Leu  Ser Ser Ser Asp Glu  Ser Glu Asn 
    1460                 1465                 1470             


Phe Pro  Lys Pro Cys Ser Gln  Leu Glu Asp Phe Lys  Val Cys Asn 
    1475                 1480                 1485             


Gly Asn  Ala Arg Arg Gly Ile  Lys Val Pro Lys Arg  Gln Ser His 
    1490                 1495                 1500             


Leu Lys  His Val Ala Arg Lys  Phe Leu Asp Asp Glu  Ala Glu Leu 
    1505                 1510                 1515             


Ser Glu  Glu Asp Ala Glu Tyr  Val Ser Ser Asp Glu  Asn Asp Glu 
    1520                 1525                 1530             


Ser Glu  Asn Glu Gln Asp Ser  Ser Leu Leu Asp Phe  Leu Asn Asp 
    1535                 1540                 1545             


Glu Thr  Gln Leu Ser Gln Ala  Ile Asn Asp Ser Glu  Met Arg Ala 
    1550                 1555                 1560             


Ile Tyr  Met Lys Ser Leu Arg  Ser Pro Met Met Asn  Asn Lys Tyr 
    1565                 1570                 1575             


Lys Met  Ile His Lys Thr His  Lys Asn Ile Asn Ile  Phe Ser Gln 
    1580                 1585                 1590             


Ile Pro  Glu Gln Asp Glu Thr  Tyr Leu Glu Asp Ser  Phe Cys Val 
    1595                 1600                 1605             


Asp Glu  Glu Glu Ser Cys Lys  Gly Gln Ser Ser Glu  Glu Glu Val 
    1610                 1615                 1620             


Cys Val  Asp Phe Asn Leu Ile  Thr Asp Asp Cys Phe  Ala Asn Ser 
    1625                 1630                 1635             


Lys Lys  Tyr Lys Thr Arg Arg  Ala Val Met Leu Lys  Glu Met Met 
    1640                 1645                 1650             


Glu Gln  Asn Cys Ala His Ser  Lys Lys Lys Leu Ser  Arg Ile Ile 
    1655                 1660                 1665             


Leu Pro  Asp Asp Ser Ser Glu  Glu Glu Asn Asn Val  Asn Asp Lys 
    1670                 1675                 1680             


Arg Glu  Ser Asn Ile Ala Val  Asn Pro Ser Thr Val  Lys Lys Asn 
    1685                 1690                 1695             


Lys Gln  Gln Asp His Cys Leu  Asn Ser Val Pro Ser  Gly Ser Ser 
    1700                 1705                 1710             


Ala Gln  Ser Lys Val Arg Ser  Thr Pro Arg Val Asn  Pro Leu Ala 
    1715                 1720                 1725             


Lys Gln  Ser Lys Gln Thr Ser  Leu Asn Leu Lys Asp  Thr Ile Ser 
    1730                 1735                 1740             


Glu Val  Ser Asp Phe Lys Pro  Gln Asn His Asn Glu  Val Gln Ser 
    1745                 1750                 1755             


Thr Thr  Pro Pro Phe Thr Thr  Val Asp Ser Gln Lys  Asp Cys Arg 
    1760                 1765                 1770             


Lys Phe  Pro Val Pro Gln Lys  Asp Gly Ser Ala Leu  Glu Asp Ser 
    1775                 1780                 1785             


Ser Thr  Ser Gly Ala Ser Cys  Ser Lys Ser Arg Pro  His Leu Ala 
    1790                 1795                 1800             


Gly Thr  His Thr Ser Leu Arg  Leu Pro Gln Glu Gly  Lys Gly Thr 
    1805                 1810                 1815             


Cys Ile  Leu Val Gly Gly His  Glu Ile Thr Ser Gly  Leu Glu Val 
    1820                 1825                 1830             


Ile Ser  Ser Leu Arg Ala Ile  His Gly Leu Gln Val  Glu Val Cys 
    1835                 1840                 1845             


Pro Leu  Asn Gly Cys Asp Tyr  Ile Val Ser Asn Arg  Met Val Val 
    1850                 1855                 1860             


Glu Arg  Arg Ser Gln Ser Glu  Met Leu Asn Ser Val  Asn Lys Asn 
    1865                 1870                 1875             


Lys Phe  Ile Glu Gln Ile Gln  His Leu Gln Ser Met  Phe Glu Arg 
    1880                 1885                 1890             


Ile Cys  Val Ile Val Glu Lys  Asp Arg Glu Lys Thr  Gly Asp Thr 
    1895                 1900                 1905             


Ser Arg  Met Phe Arg Arg Thr  Lys Ser Tyr Asp Ser  Leu Leu Thr 
    1910                 1915                 1920             


Thr Leu  Ile Gly Ala Gly Ile  Arg Ile Leu Phe Ser  Ser Cys Gln 
    1925                 1930                 1935             


Glu Glu  Thr Ala Asp Leu Leu  Lys Glu Leu Ser Leu  Val Glu Gln 
    1940                 1945                 1950             


Arg Lys  Asn Val Gly Ile His  Val Pro Thr Val Val  Asn Ser Asn 
    1955                 1960                 1965             


Lys Ser  Glu Ala Leu Gln Phe  Tyr Leu Ser Ile Pro  Asn Ile Ser 
    1970                 1975                 1980             


Tyr Ile  Thr Ala Leu Asn Met  Cys His Gln Phe Ser  Ser Val Lys 
    1985                 1990                 1995             


Arg Met  Ala Asn Ser Ser Leu  Gln Glu Ile Ser Met  Tyr Ala Gln 
    2000                 2005                 2010             


Val Thr  His Gln Lys Ala Glu  Glu Ile Tyr Arg Tyr  Ile His Tyr 
    2015                 2020                 2025             


Val Phe  Asp Ile Gln Met Leu  Pro Asn Asp Leu Asn  Gln Asp Arg 
    2030                 2035                 2040             


Leu Lys  Ser Asp Ile 
    2045             


<210>  36
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siBl

<400>  36
gctaggagtc tgcgtgcgag gatta                                             25


<210>  37
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siATRXa

<400>  37
gaggaaaccu ucaauuguaa caaagua                                           27


<210>  38
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siATRXb

<400>  38
ugcaagcucu aucaguacua cuuagau                                           27


<210>  39
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthesized siTRF1

<400>  39
cuuucuuucu uauuaagguc uuguugc                                           27


<210>  40
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized siRNaseH1

<400>  40
uugucuaaug ccuacauuua aaggaug                                           27


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  41
agagtgtctg gagcaagttg c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  42
cgtagtccat gttcacaatc g                                                 21


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  43
gtggtggcca ttttttgtct aac                                               23


<210>  44
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  44
tgctctagaa tgaacggtgg aa                                                22


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  45
tccctggaga agagctacga                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  46
agcactgtgt tggcgtacag                                                   20


<210>  47
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab probe

<400>  47
ccctaaccct aaccctaa                                                     18


<210>  48
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Made in Lab oligonucleotide

<400>  48
gtgatccgcc cgcctcggcc tcccaaagtg                                        30


<210>  49
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Leu Phe Ser Val Thr Phe Asp Leu Gly Phe Cys 
1               5                   10          


<210>  50
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  50

Asp Ile Phe Asp Cys Ser Arg Asp Leu Phe Ser Val Thr Phe Asp Leu 
1               5                   10                  15      


Gly Phe Cys Ser Pro Asp Ser Asp Asp Glu Ile Leu Glu His Thr Ser 
            20                  25                  30          


Asp 
    


