                         SEQUENCE LISTING

<110>  IFP Energies nouvelles
 
<120>  Bactries Clostridium gntiquement modifies, prparation et 
       utilisations de celles-ci

<130>  B3003PC00

<160>  134   

<170>  PatentIn version 3.5

<210>  1
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce deltacatB-fwd

<400>  1
tgttatggat tataagcggc tcgaggacgt caaaccatgt taatcattgc                  50


<210>  2
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce deltacatB-rev

<400>  2
aatctatcac tgatagggac tcgagcaatt tcaccaaaga attcgctagc                  50


<210>  3
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH076

<400>  3
catataataa aaggaaacct cttgatcg                                          28


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH077

<400>  4
attgccagcc taacacttgg                                                   20


<210>  5
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH001

<400>  5
atctccatgg acgcgtgacg tcgacataag gtaccaggaa ttagagcagc                  50


<210>  6
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH002

<400>  6
tctatctcca gctctagacc attattattc ctccaagttt gct                         43


<210>  7
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH003

<400>  7
ataatggtct agagctggag atagattatt tggtactaag                             40


<210>  8
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH004

<400>  8
tatgaccatg attacgaatt cgagctcgaa gcgcttatta ttgcattagc                  50


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pEX-fwd

<400>  9
cagattgtac tgagagtgca cc                                                22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pEX-rev

<400>  10
gtgagcggat aacaatttca cac                                               23


<210>  11
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pEC750C-fwd

<400>  11
caatattcca caatattata ttataagcta gc                                     32


<210>  12
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce M13-rev

<400>  12
caggaaacag ctatgac                                                      17


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH010

<400>  13
cggatattgc attaccagta gc                                                22


<210>  14
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH011

<400>  14
ttatcaatct cttacacatg gagc                                              24


<210>  15
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH025

<400>  15
tagtatgccg ccattattac gaca                                              24


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce RH134

<400>  16
gtcgacgtgg aattgtgagc                                                   20


<210>  17
<211>  3658
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEX-A258-deltacatB

<400>  17
ctcgagctgc agcaaaaaaa gcaccgactc ggtgccactt tttcaagttg ataacggact       60

agccttattt taacttgcta tttctagctc taaaactgtg gtctctcttt tcgttgatgg      120

tggaatgata agggtttgca ccttaatttc tcctattgag aaaatcgtct cttctcagac      180

gtcaaaccat gttaatcatt gcttttatca aaaataggat ccactctatc attgatagag      240

tttgaaactc tatcattgat agagtataat atctttgttc atgtacatca tgctatctgt      300

gagttttaga gctagaaata gcaagttaaa ataaggctag tccgttatca acttgaaaaa      360

gtggcaccga gtcggtgctt tttttgaagc ttgtctttac acttttgccc attaattttt      420

gagttcctta tttttaggga gcttttatta tttttatcat gaaaatttca taaaatactc      480

ataaactaag gatgtcttca taatcagatt agtactccat tttcaatcca tttaatctgg      540

gaatatgata ttttaattac gtattattta agatatatta acgtgtaata taataccccg      600

caaatattaa ttatcacata catatccccc ctttattggg gcattttttg tacccattat      660

tttagtattg tgcagtactt aaataaaaaa atgccgcaaa ttcattttta ttgaataatg      720

cggtatttct tctattcttt atttttatta ctctataaat aatgtaatca agacatgact      780

atctaaatat atgatatctt aattcataat tcgggcctcc taaaaatttt cgtaattcta      840

ttttagaagg cttttttccg tgacctagcc atttcaatct cctttttaca atgatattta      900

cgctttagtt tattatagca cattctgtaa taccgaacta ttcaattttc agagaccatt      960

ttttattgat tcataactta agaatactac gaattactct aatattttac tttttcttat     1020

ctcttgttat tttaacatcg gaattactac taatattaat ttttattttt ccatccgcat     1080

ttgctccaac atttttttaa ctatactttc cttttgttaa taaattatgt tattgttgaa     1140

caatataaga aaagtgcgta acatttttta ttaaaaataa ttaggtattt ctatctgtgg     1200

ggtaccctcg aggtggcagc tctagagcta gcgaattctt tggtgaaatt gttatccgct     1260

cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg     1320

agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct     1380

gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg     1440

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     1500

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     1560

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     1620

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     1680

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     1740

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     1800

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     1860

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     1920

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     1980

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     2040

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc     2100

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     2160

cggtggtttt tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga     2220

tcctttgatc ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat     2280

tttggtcatg agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag     2340

ttttaaatca atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat     2400

cagtgaggca cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc     2460

cgtcgtgtag ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat     2520

accgcgcgaa ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag     2580

ggccgagcgc agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg     2640

ccgggaagct agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc     2700

tacaggcatc gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca     2760

acgatcaagg cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg     2820

tcctccgatc gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc     2880

actgcataat tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta     2940

ctcaaccaag tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc     3000

aatacgggat aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg     3060

ttcttcgggg cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc     3120

cactcgtgca cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc     3180

aaaaacagga aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat     3240

actcatactc ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag     3300

cggatacata tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc     3360

ccgaaaagtg ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa     3420

taggcgtatc acgaggccct ttcgtctcgc gcgtttcggt gatgacggtg aaaacctctg     3480

acacatgcag ctcccggaga cggtcacagc ttgtctgtaa gcggatgccg ggagcagaca     3540

agcccgtcag ggcgcgtcag cgggtgttgg cgggtgtcgg ggctggctta actatgcggc     3600

atcagagcag attgtactga gagtttggca attggtcgac ctcgagggcg cgcccgta       3658


<210>  18
<211>  660
<212>  DNA
<213>  Clostridium beijerinckii

<400>  18
atgaatttta atttgataga tattaatcat tggagtagaa agccatactt tgaacattat       60

ttaaacaatg tgaaatgtac ttatagtatg actgccaata tagaaataac tgatttattg      120

tatgaaatta aacttaaaaa tattaaattt tatcctaccc ttatttatat gattgcaact      180

gtggttaata agcataaaga attccgtatt tgttttgatc atgaaggtag tttaggatat      240

tgggatagca tgaatccaag ctatactatt tttcataaag aaaacgaaac attttcaagt      300

atttggacgg aatataacaa aagtttttta cgtttttata gtgattatct tgacgatata      360

aaaaactatg gaaatatcat gaagtttact ccgaaatcaa atgaacctga caatacattt      420

tctgtatcaa gcattccttg ggtgagtttt acaggattta acttgaatgt gtataatgaa      480

ggaacatatt taattcctat ttttactgca ggaaagtatt tcaaacaaga aaataaaata      540

tttattccta tatcaataca agtacatcat gctatctgtg acggttatca tgctagtaga      600

tttattaatg aaatgcaaga attagcattt agttttcaag aatggttaga aaataaataa      660


<210>  19
<211>  160
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cassette d'expression ARNg

<400>  19
actctatcat tgatagagtt tgaaactcta tcattgatag agtataatat ctttgttcat       60

gtacatcatg ctatctgtga gttttagagc tagaaatagc aagttaaaat aaggctagtc      120

cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt                            160


<210>  20
<211>  808
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matrice d'dition

<400>  20
gtctttacac ttttgcccat taatttttga gttccttatt tttagggagc ttttattatt       60

tttatcatga aaatttcata aaatactcat aaactaagga tgtcttcata atcagattag      120

tactccattt tcaatccatt taatctggga atatgatatt ttaattacgt attatttaag      180

atatattaac gtgtaatata ataccccgca aatattaatt atcacataca tatcccccct      240

ttattggggc attttttgta cccattattt tagtattgtg cagtacttaa ataaaaaaat      300

gccgcaaatt catttttatt gaataatgcg gtatttcttc tattctttat ttttattact      360

ctataaataa tgtaatcaag acatgactat ctaaatatat gatatcttaa ttcataattc      420

gggcctccta aaaattttcg taattctatt ttagaaggct tttttccgtg acctagccat      480

ttcaatctcc tttttacaat gatatttacg ctttagttta ttatagcaca ttctgtaata      540

ccgaactatt caattttcag agaccatttt ttattgattc ataacttaag aatactacga      600

attactctaa tattttactt tttcttatct cttgttattt taacatcgga attactacta      660

atattaattt ttatttttcc atccgcattt gctccaacat ttttttaact atactttcct      720

tttgttaata aattatgtta ttgttgaaca atataagaaa agtgcgtaac attttttatt      780

aaaaataatt aggtatttct atctgtgg                                         808


<210>  21
<211>  9954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCas9ind-deltacatB

<400>  21
catggataaa aagtacagta ttggtctaga cataggaact aactctgttg ggtgggctgt       60

tataacagat gaatataaag ttccatcaaa aaaatttaaa gtattaggaa acactgatag      120

acattcaata aaaaaaaact tgataggtgc tttattattc gattcaggag agactgctga      180

agctacacgt ttaaaaagaa cagctagacg tagatataca agaagaaaaa ataggatatg      240

ttatcttcaa gaaattttta gtaatgaaat ggcaaaagtt gatgattcat tctttcacag      300

actagaagaa agtttcttag ttgaagaaga taagaagcat gaaagacacc ctatttttgg      360

taatatcgta gatgaagtag catatcatga gaagtatcca actatctatc atttaagaaa      420

gaaattagtt gattctacag ataaagctga tctgagatta atatatttag ctttagctca      480

tatgattaaa tttagaggac attttttaat agaaggtgat ttaaacccag acaacagcga      540

tgtagataaa ttatttatcc aattagttca aacttataat caattattcg aagagaatcc      600

aattaatgca agtggtgtag acgctaaggc tatattatca gctagattat caaaatctag      660

aagattagaa aatctaatag ctcaacttcc tggagaaaag aaaaatggac tttttgggaa      720

cctaatagct ctctcactcg gactaacacc aaattttaaa agcaattttg atcttgctga      780

agacgcaaag ttacaactat caaaggatac atacgatgat gatttagata atttgttagc      840

tcaaataggt gatcaatatg ctgatttgtt tcttgcagca aaaaacttaa gtgatgcaat      900

tttactatca gatatactta gagtaaatac agaaataaca aaggctcctt tatcagcaag      960

tatgattaaa cgatatgatg agcatcatca agatttaaca ttattaaagg cacttgtaag     1020

acaacaatta ccagaaaaat ataaagaaat tttctttgat caatctaaaa atggatatgc     1080

tggatatata gacggtggag caagtcaaga agagttttat aaatttataa agcctatttt     1140

agaaaaaatg gatggaactg aagaattact tgttaaactt aacagagaag atttacttag     1200

aaaacaaaga acttttgata atggttcaat tcctcaccaa attcatttag gagaattaca     1260

tgctatacta agaagacaag aagattttta tccatttctt aaagataata gagaaaaaat     1320

tgaaaaaatt ttaactttta gaataccata ttatgtagga ccacttgcaa ggggaaattc     1380

aagatttgca tggatgacta gaaaatcaga agaaactata accccgtgga attttgaaga     1440

agtagtagat aaaggagcta gtgctcaatc atttatagaa agaatgacaa attttgataa     1500

gaatcttcct aacgaaaagg ttttgccaaa gcatagcctt ctttatgagt attttacagt     1560

ttataatgag cttactaaag taaaatacgt tacagaagga atgagaaaac cagcattttt     1620

gtctggtgaa caaaagaaag caatagtaga cctattattt aaaacaaata ggaaggttac     1680

cgtaaagcaa cttaaagaag attacttcaa aaaaattgaa tgctttgata gtgttgaaat     1740

atcaggagtt gaagatagat ttaatgcttc acttggtaca tatcacgatc tcttaaaaat     1800

tataaaagat aaggattttt tagataatga agaaaatgaa gatattcttg aagatatagt     1860

attaacattg acactttttg aagatagaga aatgatagaa gaaagattaa aaacatatgc     1920

acatcttttt gatgataagg ttatgaagca acttaaaaga agaagatata caggttgggg     1980

acgtttgtca agaaagctaa ttaatggtat tagagataaa caatcaggaa agactattct     2040

cgattttctt aaatcagatg gatttgctaa tagaaacttt atgcaattaa ttcatgatga     2100

ttctcttact ttcaaagagg atattcaaaa ggctcaagtt tctggacaag gcgatagctt     2160

acacgaacac attgctaacc ttgcagggag ccccgctatc aaaaaaggaa ttttacaaac     2220

agttaaagtt gtagatgaac ttgttaaagt tatgggaaga cacaaacctg agaatatagt     2280

tatagaaatg gccagagaaa atcaaacaac acaaaaagga caaaaaaatt ctagagagag     2340

aatgaagaga attgaagaag gaataaaaga gctaggatca caaatattaa aagaacatcc     2400

agttgaaaat actcaattgc aaaatgaaaa gttatatttg tattacttac aaaatggaag     2460

agatatgtat gttgatcaag aactcgatat taatagatta agtgactatg atgttgatca     2520

tattgttcct caatcatttt taaaagatga ttcaatcgat aacaaagtat taactagatc     2580

agataaaaat agaggaaagt cagataatgt accatctgaa gaagttgtta aaaaaatgaa     2640

gaactattgg agacaacttt taaatgcaaa gctaattaca caaagaaaat ttgacaattt     2700

aacaaaagca gaaagaggag gattaagcga attagacaaa gctggattta taaaaagaca     2760

acttgttgag acaagacaaa taactaagca tgttgctcaa atacttgatt caagaatgaa     2820

tacaaaatat gatgaaaatg ataaattaat cagagaagta aaagtaataa cattaaagtc     2880

aaaattagta tcagatttca gaaaggattt tcaattttac aaagttcgtg aaataaataa     2940

ctatcatcat gctcatgatg catacttaaa tgctgttgta ggaactgctc ttattaagaa     3000

atatcctaaa ctagaaagcg aatttgttta tggagattat aaagtttatg atgtgcgcaa     3060

aatgatcgcg aaatccgaac aagaaatcgg taaggctaca gcaaaatatt tcttttatag     3120

taatataatg aattttttta agacagaaat aactttggct aatggtgaaa tcagaaaaag     3180

accacttatc gaaacaaatg gagagacagg agaaatagta tgggataaag gaagagattt     3240

tgctactgtt agaaaagtac taagtatgcc acaagtaaat atcgtaaaga aaactgaagt     3300

tcaaactgga ggtttctcta aggaatcaat tttacctaag agaaattcag ataagttaat     3360

tgcaaggaaa aaagattggg acccaaaaaa atacggtggt tttgatagtc caacagttgc     3420

ctatagtgtt cttgtagtag cgaaagttga gaaaggtaag tcaaaaaagt tgaaaagcgt     3480

aaaagaactt cttggtatca caattatgga aagatcttca tttgaaaaaa atccaattga     3540

ctttttagaa gctaagggtt ataaagaagt taaaaaggat ttaatcataa aactaccaaa     3600

gtatagtcta tttgaactcg aaaacggaag aaaacgaatg ctcgctagcg caggagaact     3660

tcaaaaagga aatgaacttg cgctgccatc aaagtatgta aatttcttat atttagcttc     3720

tcattatgag aaattaaaag gatcaccaga ggataatgaa caaaagcaac tatttgtaga     3780

acaacacaaa cattatttag atgaaataat agaacaaata tctgaatttt ctaaaagagt     3840

tatacttgcc gacgcaaatc tagataaggt gctttcagcg tataataaac acagagataa     3900

accaataaga gaacaagcag aaaacattat ccatcttttt acattaacta atcttggtgc     3960

accagctgca tttaagtact ttgatacaac aatagataga aaaagataca catctactaa     4020

agaagtatta gacgcaactt taatacatca atctattaca gggctttatg aaacaagaat     4080

tgatttaagt caactaggcg gagattaagt cgacaaagta ttgttaaaaa taactctgta     4140

gaattataaa ttagttctac agagttattt tttgacccgg gtatattgat aaaaataata     4200

atagtgggta taattaagtt gttaggaggt tagttagaat gatgtcaaga ttagataaaa     4260

gtaaagtgat taacagcgca ttagagctgc ttaatgaggt cggaatcgaa ggtttaacaa     4320

cccgtaaact cgcccagaag ctaggtgtag agcagcctac attgtattgg catgtaaaaa     4380

ataagcgggc tttgctcgac gccttagcca ttgagatgtt agataggcac catactcact     4440

tttgcccttt agaaggggaa agctggcaag attttttacg taataacgct aaaagtttta     4500

gatgtgcttt actaagtcat cgcgatggag caaaagtaca tttaggtaca cggcctacag     4560

aaaaacagta tgaaactctc gaaaatcaat tagccttttt atgccaacaa ggtttttcac     4620

tagagaatgc attatatgca ctcagcgctg tggggcattt tactttaggt tgcgtattgg     4680

aagatcaaga gcatcaagtc gctaaagaag aaagggaaac acctactact gatagtatgc     4740

cgccattatt acgacaagct atcgaattat ttgatcacca aggtgcagag ccagccttct     4800

tattcggcct tgaattgatc atatgcggat tagaaaaaca acttaaatgt gaaagtgggt     4860

cttaaaagca gcataacctt tttccgtgat ggtaacttca cggtaaccaa gatgtcgagt     4920

tgagctcgaa ttcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     4980

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     5040

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     5100

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     5160

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     5220

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     5280

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     5340

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     5400

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     5460

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     5520

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     5580

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     5640

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     5700

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     5760

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag     5820

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     5880

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5940

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     6000

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     6060

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccag gtccactgcc     6120

gggcctcttg cgggatcaaa agaaaaacga aatgatacac caatcagtgc aaaaaaagat     6180

ataatgggag ataagacggt tcgtgttcgt gctgacttgc accatatcat aaaaatcgaa     6240

acagcaaaga atggcggaaa cgtaaaagaa gttatggaaa taagacttag aagcaaactt     6300

aagagtgtgt tgatagtgca gtatcttaaa attttgtata ataggaattg aagttaaatt     6360

agatgctaaa aatttgtaat taagaaggag tgattacatg aacaaaaata taaaatattc     6420

tcaaaacttt ttaacgagtg aaaaagtact caaccaaata ataaaacaat tgaatttaaa     6480

agaaaccgat accgtttacg aaattggaac aggtaaaggg catttaacga cgaaactggc     6540

taaaataagt aaacaggtaa cgtctattga attagacagt catctattca acttatcgtc     6600

agaaaaatta aaactgaata ctcgtgtcac tttaattcac caagatattc tacagtttca     6660

attccctaac aaacagaggt ataaaattgt tgggagtatt ccttaccatt taagcacaca     6720

aattattaaa aaagtggttt ttgaaagcca tgcgtctgac atctatctga ttgttgaaga     6780

aggattctac aagcgtacct tggatattca ccgaacacta gggttgctct tgcacactca     6840

agtctcgatt cagcaattgc ttaagctgcc agcggaatgc tttcatccta aaccaaaagt     6900

aaacagtgtc ttaataaaac ttacccgcca taccacagat gttccagata aatattggaa     6960

gctatatacg tactttgttt caaaatgggt caatcgagaa tatcgtcaac tgtttactaa     7020

aaatcagttt catcaagcaa tgaaacacgc caaagtaaac aatttaagta ccgttactta     7080

tgagcaagta ttgtctattt ttaatagtta tctattattt aacgggagga aataattcta     7140

tgagtcccta ggcaggcctc cgccattatt tttttgaaca attgacaatt catttcttat     7200

tttttattaa gtgatagtca aaaggcataa cagtgctgaa tagaaagaaa tttacagaaa     7260

agaaaattat agaatttagt atgattaatt atactcattt atgaatgttt aattgaatac     7320

aaaaaaaaat acttgttatg tattcaatta cgggttaaaa tatagacaag ttgaaaaatt     7380

taataaaaaa ataagtcctc agctcttata tattaagcta ccaacttagt atataagcca     7440

aaacttaaat gtgctaccaa cacatcaagc cgttagagaa ctctatctat agcaatattt     7500

caaatgtacc gacatacaag agaaacatta actatatata ttcaatttat gagattatct     7560

taacagatat aaatgtaaat tgcaataagt aagatttaga agtttatagc ctttgtgtat     7620

tggaagcagt acgcaaaggc ttttttattt gataaaaatt agaagtatat ttattttttc     7680

ataattaatt tatgaaaatg aaagggggtg agcaaagtga cagaggaaag cagtatctta     7740

tcaaataaca aggtattagc aatatcatta ttgactttag cagtaaacat tatgactttt     7800

atagtgcttg tagctaagta gtacgaaagg gggagcttta aaaagctcct tggaatacat     7860

agaattcata aattaattta tgaaaagaag ggcgtatatg aaaacttgta aaaattgcaa     7920

agagtttatt aaagatactg aaatatgcaa aatacattcg ttgatgattc atgataaaac     7980

agtagcaacc tattgcagta aatacaatga gtcaagatgt ttacataaag ggaaagtcca     8040

atgtattaat tgttcaaaga tgaaccgata tggatggtgt gccataaaaa tgagatgttt     8100

tacagaggaa gaacagaaaa aagaacgtac atgcattaaa tattatgcaa ggagctttaa     8160

aaaagctcat gtaaagaaga gtaaaaagaa aaaataattt atttattaat ttaatattga     8220

gagtgccgac acagtatgca ctaaaaaata tatctgtggt gtagtgagcc gatacaaaag     8280

gatagtcact cgcattttca taatacatct tatgttatga ttatgtgtcg gtgggacttc     8340

acgacgaaaa cccacaataa aaaaagagtt cggggtaggg ttaagcatag ttgaggcaac     8400

taaacaatca agctaggata tgcagtagca gaccgtaagg tcgttgttta ggtgtgttgt     8460

aatacatacg ctattaagat gtaaaaatac ggataccaat gaagggaaaa gtataatttt     8520

tggatgtagt ttgtttgttc atctatgggc aaactacgtc caaagccgtt tccaaatctg     8580

ctaaaaagta tatcctttct aaaatcaaag tcaagtatga aatcataaat aaagtttaat     8640

tttgaagtta ttatgatatt atgtttttct attaaaataa attaagtata tagaatagtt     8700

taataatagt atatacttaa tgtgataagt gtctgacagt gtcacagaaa ggatgattgt     8760

tatggattat aagcggctcg aggacgtcaa accatgttaa tcattgcttt tatcaaaaat     8820

aggatccact ctatcattga tagagtttga aactctatca ttgatagagt ataatatctt     8880

tgttcatgta catcatgcta tctgtgagtt ttagagctag aaatagcaag ttaaaataag     8940

gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttt gaagcttgtc     9000

tttacacttt tgcccattaa tttttgagtt ccttattttt agggagcttt tattattttt     9060

atcatgaaaa tttcataaaa tactcataaa ctaaggatgt cttcataatc agattagtac     9120

tccattttca atccatttaa tctgggaata tgatatttta attacgtatt atttaagata     9180

tattaacgtg taatataata ccccgcaaat attaattatc acatacatat ccccccttta     9240

ttggggcatt ttttgtaccc attattttag tattgtgcag tacttaaata aaaaaatgcc     9300

gcaaattcat ttttattgaa taatgcggta tttcttctat tctttatttt tattactcta     9360

taaataatgt aatcaagaca tgactatcta aatatatgat atcttaattc ataattcggg     9420

cctcctaaaa attttcgtaa ttctatttta gaaggctttt ttccgtgacc tagccatttc     9480

aatctccttt ttacaatgat atttacgctt tagtttatta tagcacattc tgtaataccg     9540

aactattcaa ttttcagaga ccatttttta ttgattcata acttaagaat actacgaatt     9600

actctaatat tttacttttt cttatctctt gttattttaa catcggaatt actactaata     9660

ttaattttta tttttccatc cgcatttgct ccaacatttt tttaactata ctttcctttt     9720

gttaataaat tatgttattg ttgaacaata taagaaaagt gcgtaacatt ttttattaaa     9780

aataattagg tatttctatc tgtggggtac cctcgaggtg gcagctctag agctagcgaa     9840

ttctttggtg aaattgctcg agtccctatc agtgatagat tgaaactcta tcattgatag     9900

agtataatat ctttgttcat tagagcgata aacttgaatt tgagagggaa cttc           9954


<210>  22
<211>  8874
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCas9ind

<400>  22
catggataaa aagtacagta ttggtctaga cataggaact aactctgttg ggtgggctgt       60

tataacagat gaatataaag ttccatcaaa aaaatttaaa gtattaggaa acactgatag      120

acattcaata aaaaaaaact tgataggtgc tttattattc gattcaggag agactgctga      180

agctacacgt ttaaaaagaa cagctagacg tagatataca agaagaaaaa ataggatatg      240

ttatcttcaa gaaattttta gtaatgaaat ggcaaaagtt gatgattcat tctttcacag      300

actagaagaa agtttcttag ttgaagaaga taagaagcat gaaagacacc ctatttttgg      360

taatatcgta gatgaagtag catatcatga gaagtatcca actatctatc atttaagaaa      420

gaaattagtt gattctacag ataaagctga tctgagatta atatatttag ctttagctca      480

tatgattaaa tttagaggac attttttaat agaaggtgat ttaaacccag acaacagcga      540

tgtagataaa ttatttatcc aattagttca aacttataat caattattcg aagagaatcc      600

aattaatgca agtggtgtag acgctaaggc tatattatca gctagattat caaaatctag      660

aagattagaa aatctaatag ctcaacttcc tggagaaaag aaaaatggac tttttgggaa      720

cctaatagct ctctcactcg gactaacacc aaattttaaa agcaattttg atcttgctga      780

agacgcaaag ttacaactat caaaggatac atacgatgat gatttagata atttgttagc      840

tcaaataggt gatcaatatg ctgatttgtt tcttgcagca aaaaacttaa gtgatgcaat      900

tttactatca gatatactta gagtaaatac agaaataaca aaggctcctt tatcagcaag      960

tatgattaaa cgatatgatg agcatcatca agatttaaca ttattaaagg cacttgtaag     1020

acaacaatta ccagaaaaat ataaagaaat tttctttgat caatctaaaa atggatatgc     1080

tggatatata gacggtggag caagtcaaga agagttttat aaatttataa agcctatttt     1140

agaaaaaatg gatggaactg aagaattact tgttaaactt aacagagaag atttacttag     1200

aaaacaaaga acttttgata atggttcaat tcctcaccaa attcatttag gagaattaca     1260

tgctatacta agaagacaag aagattttta tccatttctt aaagataata gagaaaaaat     1320

tgaaaaaatt ttaactttta gaataccata ttatgtagga ccacttgcaa ggggaaattc     1380

aagatttgca tggatgacta gaaaatcaga agaaactata accccgtgga attttgaaga     1440

agtagtagat aaaggagcta gtgctcaatc atttatagaa agaatgacaa attttgataa     1500

gaatcttcct aacgaaaagg ttttgccaaa gcatagcctt ctttatgagt attttacagt     1560

ttataatgag cttactaaag taaaatacgt tacagaagga atgagaaaac cagcattttt     1620

gtctggtgaa caaaagaaag caatagtaga cctattattt aaaacaaata ggaaggttac     1680

cgtaaagcaa cttaaagaag attacttcaa aaaaattgaa tgctttgata gtgttgaaat     1740

atcaggagtt gaagatagat ttaatgcttc acttggtaca tatcacgatc tcttaaaaat     1800

tataaaagat aaggattttt tagataatga agaaaatgaa gatattcttg aagatatagt     1860

attaacattg acactttttg aagatagaga aatgatagaa gaaagattaa aaacatatgc     1920

acatcttttt gatgataagg ttatgaagca acttaaaaga agaagatata caggttgggg     1980

acgtttgtca agaaagctaa ttaatggtat tagagataaa caatcaggaa agactattct     2040

cgattttctt aaatcagatg gatttgctaa tagaaacttt atgcaattaa ttcatgatga     2100

ttctcttact ttcaaagagg atattcaaaa ggctcaagtt tctggacaag gcgatagctt     2160

acacgaacac attgctaacc ttgcagggag ccccgctatc aaaaaaggaa ttttacaaac     2220

agttaaagtt gtagatgaac ttgttaaagt tatgggaaga cacaaacctg agaatatagt     2280

tatagaaatg gccagagaaa atcaaacaac acaaaaagga caaaaaaatt ctagagagag     2340

aatgaagaga attgaagaag gaataaaaga gctaggatca caaatattaa aagaacatcc     2400

agttgaaaat actcaattgc aaaatgaaaa gttatatttg tattacttac aaaatggaag     2460

agatatgtat gttgatcaag aactcgatat taatagatta agtgactatg atgttgatca     2520

tattgttcct caatcatttt taaaagatga ttcaatcgat aacaaagtat taactagatc     2580

agataaaaat agaggaaagt cagataatgt accatctgaa gaagttgtta aaaaaatgaa     2640

gaactattgg agacaacttt taaatgcaaa gctaattaca caaagaaaat ttgacaattt     2700

aacaaaagca gaaagaggag gattaagcga attagacaaa gctggattta taaaaagaca     2760

acttgttgag acaagacaaa taactaagca tgttgctcaa atacttgatt caagaatgaa     2820

tacaaaatat gatgaaaatg ataaattaat cagagaagta aaagtaataa cattaaagtc     2880

aaaattagta tcagatttca gaaaggattt tcaattttac aaagttcgtg aaataaataa     2940

ctatcatcat gctcatgatg catacttaaa tgctgttgta ggaactgctc ttattaagaa     3000

atatcctaaa ctagaaagcg aatttgttta tggagattat aaagtttatg atgtgcgcaa     3060

aatgatcgcg aaatccgaac aagaaatcgg taaggctaca gcaaaatatt tcttttatag     3120

taatataatg aattttttta agacagaaat aactttggct aatggtgaaa tcagaaaaag     3180

accacttatc gaaacaaatg gagagacagg agaaatagta tgggataaag gaagagattt     3240

tgctactgtt agaaaagtac taagtatgcc acaagtaaat atcgtaaaga aaactgaagt     3300

tcaaactgga ggtttctcta aggaatcaat tttacctaag agaaattcag ataagttaat     3360

tgcaaggaaa aaagattggg acccaaaaaa atacggtggt tttgatagtc caacagttgc     3420

ctatagtgtt cttgtagtag cgaaagttga gaaaggtaag tcaaaaaagt tgaaaagcgt     3480

aaaagaactt cttggtatca caattatgga aagatcttca tttgaaaaaa atccaattga     3540

ctttttagaa gctaagggtt ataaagaagt taaaaaggat ttaatcataa aactaccaaa     3600

gtatagtcta tttgaactcg aaaacggaag aaaacgaatg ctcgctagcg caggagaact     3660

tcaaaaagga aatgaacttg cgctgccatc aaagtatgta aatttcttat atttagcttc     3720

tcattatgag aaattaaaag gatcaccaga ggataatgaa caaaagcaac tatttgtaga     3780

acaacacaaa cattatttag atgaaataat agaacaaata tctgaatttt ctaaaagagt     3840

tatacttgcc gacgcaaatc tagataaggt gctttcagcg tataataaac acagagataa     3900

accaataaga gaacaagcag aaaacattat ccatcttttt acattaacta atcttggtgc     3960

accagctgca tttaagtact ttgatacaac aatagataga aaaagataca catctactaa     4020

agaagtatta gacgcaactt taatacatca atctattaca gggctttatg aaacaagaat     4080

tgatttaagt caactaggcg gagattaagt cgacaaagta ttgttaaaaa taactctgta     4140

gaattataaa ttagttctac agagttattt tttgacccgg gtatattgat aaaaataata     4200

atagtgggta taattaagtt gttaggaggt tagttagaat gatgtcaaga ttagataaaa     4260

gtaaagtgat taacagcgca ttagagctgc ttaatgaggt cggaatcgaa ggtttaacaa     4320

cccgtaaact cgcccagaag ctaggtgtag agcagcctac attgtattgg catgtaaaaa     4380

ataagcgggc tttgctcgac gccttagcca ttgagatgtt agataggcac catactcact     4440

tttgcccttt agaaggggaa agctggcaag attttttacg taataacgct aaaagtttta     4500

gatgtgcttt actaagtcat cgcgatggag caaaagtaca tttaggtaca cggcctacag     4560

aaaaacagta tgaaactctc gaaaatcaat tagccttttt atgccaacaa ggtttttcac     4620

tagagaatgc attatatgca ctcagcgctg tggggcattt tactttaggt tgcgtattgg     4680

aagatcaaga gcatcaagtc gctaaagaag aaagggaaac acctactact gatagtatgc     4740

cgccattatt acgacaagct atcgaattat ttgatcacca aggtgcagag ccagccttct     4800

tattcggcct tgaattgatc atatgcggat tagaaaaaca acttaaatgt gaaagtgggt     4860

cttaaaagca gcataacctt tttccgtgat ggtaacttca cggtaaccaa gatgtcgagt     4920

tgagctcgaa ttcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     4980

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     5040

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     5100

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     5160

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     5220

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     5280

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     5340

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     5400

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     5460

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     5520

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     5580

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     5640

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     5700

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     5760

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag     5820

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     5880

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5940

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     6000

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     6060

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccag gtccactgcc     6120

gggcctcttg cgggatcaaa agaaaaacga aatgatacac caatcagtgc aaaaaaagat     6180

ataatgggag ataagacggt tcgtgttcgt gctgacttgc accatatcat aaaaatcgaa     6240

acagcaaaga atggcggaaa cgtaaaagaa gttatggaaa taagacttag aagcaaactt     6300

aagagtgtgt tgatagtgca gtatcttaaa attttgtata ataggaattg aagttaaatt     6360

agatgctaaa aatttgtaat taagaaggag tgattacatg aacaaaaata taaaatattc     6420

tcaaaacttt ttaacgagtg aaaaagtact caaccaaata ataaaacaat tgaatttaaa     6480

agaaaccgat accgtttacg aaattggaac aggtaaaggg catttaacga cgaaactggc     6540

taaaataagt aaacaggtaa cgtctattga attagacagt catctattca acttatcgtc     6600

agaaaaatta aaactgaata ctcgtgtcac tttaattcac caagatattc tacagtttca     6660

attccctaac aaacagaggt ataaaattgt tgggagtatt ccttaccatt taagcacaca     6720

aattattaaa aaagtggttt ttgaaagcca tgcgtctgac atctatctga ttgttgaaga     6780

aggattctac aagcgtacct tggatattca ccgaacacta gggttgctct tgcacactca     6840

agtctcgatt cagcaattgc ttaagctgcc agcggaatgc tttcatccta aaccaaaagt     6900

aaacagtgtc ttaataaaac ttacccgcca taccacagat gttccagata aatattggaa     6960

gctatatacg tactttgttt caaaatgggt caatcgagaa tatcgtcaac tgtttactaa     7020

aaatcagttt catcaagcaa tgaaacacgc caaagtaaac aatttaagta ccgttactta     7080

tgagcaagta ttgtctattt ttaatagtta tctattattt aacgggagga aataattcta     7140

tgagtcccta ggcaggcctc cgccattatt tttttgaaca attgacaatt catttcttat     7200

tttttattaa gtgatagtca aaaggcataa cagtgctgaa tagaaagaaa tttacagaaa     7260

agaaaattat agaatttagt atgattaatt atactcattt atgaatgttt aattgaatac     7320

aaaaaaaaat acttgttatg tattcaatta cgggttaaaa tatagacaag ttgaaaaatt     7380

taataaaaaa ataagtcctc agctcttata tattaagcta ccaacttagt atataagcca     7440

aaacttaaat gtgctaccaa cacatcaagc cgttagagaa ctctatctat agcaatattt     7500

caaatgtacc gacatacaag agaaacatta actatatata ttcaatttat gagattatct     7560

taacagatat aaatgtaaat tgcaataagt aagatttaga agtttatagc ctttgtgtat     7620

tggaagcagt acgcaaaggc ttttttattt gataaaaatt agaagtatat ttattttttc     7680

ataattaatt tatgaaaatg aaagggggtg agcaaagtga cagaggaaag cagtatctta     7740

tcaaataaca aggtattagc aatatcatta ttgactttag cagtaaacat tatgactttt     7800

atagtgcttg tagctaagta gtacgaaagg gggagcttta aaaagctcct tggaatacat     7860

agaattcata aattaattta tgaaaagaag ggcgtatatg aaaacttgta aaaattgcaa     7920

agagtttatt aaagatactg aaatatgcaa aatacattcg ttgatgattc atgataaaac     7980

agtagcaacc tattgcagta aatacaatga gtcaagatgt ttacataaag ggaaagtcca     8040

atgtattaat tgttcaaaga tgaaccgata tggatggtgt gccataaaaa tgagatgttt     8100

tacagaggaa gaacagaaaa aagaacgtac atgcattaaa tattatgcaa ggagctttaa     8160

aaaagctcat gtaaagaaga gtaaaaagaa aaaataattt atttattaat ttaatattga     8220

gagtgccgac acagtatgca ctaaaaaata tatctgtggt gtagtgagcc gatacaaaag     8280

gatagtcact cgcattttca taatacatct tatgttatga ttatgtgtcg gtgggacttc     8340

acgacgaaaa cccacaataa aaaaagagtt cggggtaggg ttaagcatag ttgaggcaac     8400

taaacaatca agctaggata tgcagtagca gaccgtaagg tcgttgttta ggtgtgttgt     8460

aatacatacg ctattaagat gtaaaaatac ggataccaat gaagggaaaa gtataatttt     8520

tggatgtagt ttgtttgttc atctatgggc aaactacgtc caaagccgtt tccaaatctg     8580

ctaaaaagta tatcctttct aaaatcaaag tcaagtatga aatcataaat aaagtttaat     8640

tttgaagtta ttatgatatt atgtttttct attaaaataa attaagtata tagaatagtt     8700

taataatagt atatacttaa tgtgataagt gtctgacagt gtcacagaaa ggatgattgt     8760

tatggattat aagcggctcg agtccctatc agtgatagat tgaaactcta tcattgatag     8820

agtataatat ctttgttcat tagagcgata aacttgaatt tgagagggaa cttc           8874


<210>  23
<211>  10534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCas9acr

<400>  23
cgaattcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc       60

cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct      120

aactcacatt aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc      180

agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt      240

ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag      300

ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca      360

tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt      420

tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc      480

gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct      540

ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg      600

tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca      660

agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact      720

atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta      780

acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta      840

actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct      900

tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt      960

tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga     1020

tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca     1080

tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat     1140

caatctaaag tatatatgag taaacttggt ctgacagtta ccaggtccac tgccgggcct     1200

cttgcgggat caaaagaaaa acgaaatgat acaccaatca gtgcaaaaaa agatataatg     1260

ggagataaga cggttcgtgt tcgtgctgac ttgcaccata tcataaaaat cgaaacagca     1320

aagaatggcg gaaacgtaaa agaagttatg gaaataagac ttagaagcaa acttaagagt     1380

gtgttgatag tgcagtatct taaaattttg tataatagga attgaagtta aattagatgc     1440

taaaaatttg taattaagaa ggagtgatta catgaacaaa aatataaaat attctcaaaa     1500

ctttttaacg agtgaaaaag tactcaacca aataataaaa caattgaatt taaaagaaac     1560

cgataccgtt tacgaaattg gaacaggtaa agggcattta acgacgaaac tggctaaaat     1620

aagtaaacag gtaacgtcta ttgaattaga cagtcatcta ttcaacttat cgtcagaaaa     1680

attaaaactg aatactcgtg tcactttaat tcaccaagat attctacagt ttcaattccc     1740

taacaaacag aggtataaaa ttgttgggag tattccttac catttaagca cacaaattat     1800

taaaaaagtg gtttttgaaa gccatgcgtc tgacatctat ctgattgttg aagaaggatt     1860

ctacaagcgt accttggata ttcaccgaac actagggttg ctcttgcaca ctcaagtctc     1920

gattcagcaa ttgcttaagc tgccagcgga atgctttcat cctaaaccaa aagtaaacag     1980

tgtcttaata aaacttaccc gccataccac agatgttcca gataaatatt ggaagctata     2040

tacgtacttt gtttcaaaat gggtcaatcg agaatatcgt caactgttta ctaaaaatca     2100

gtttcatcaa gcaatgaaac acgccaaagt aaacaattta agtaccgtta cttatgagca     2160

agtattgtct atttttaata gttatctatt atttaacggg aggaaataat tctatgagtc     2220

cctaggcagg cctccgccat tatttttttg aacaattgac aattcatttc ttatttttta     2280

ttaagtgata gtcaaaaggc ataacagtgc tgaatagaaa gaaatttaca gaaaagaaaa     2340

ttatagaatt tagtatgatt aattatactc atttatgaat gtttaattga atacaaaaaa     2400

aaatacttgt tatgtattca attacgggtt aaaatataga caagttgaaa aatttaataa     2460

aaaaataagt cctcagctct tatatattaa gctaccaact tagtatataa gccaaaactt     2520

aaatgtgcta ccaacacatc aagccgttag agaactctat ctatagcaat atttcaaatg     2580

taccgacata caagagaaac attaactata tatattcaat ttatgagatt atcttaacag     2640

atataaatgt aaattgcaat aagtaagatt tagaagttta tagcctttgt gtattggaag     2700

cagtacgcaa aggctttttt atttgataaa aattagaagt atatttattt tttcataatt     2760

aatttatgaa aatgaaaggg ggtgagcaaa gtgacagagg aaagcagtat cttatcaaat     2820

aacaaggtat tagcaatatc attattgact ttagcagtaa acattatgac ttttatagtg     2880

cttgtagcta agtagtacga aagggggagc tttaaaaagc tccttggaat acatagaatt     2940

cataaattaa tttatgaaaa gaagggcgta tatgaaaact tgtaaaaatt gcaaagagtt     3000

tattaaagat actgaaatat gcaaaataca ttcgttgatg attcatgata aaacagtagc     3060

aacctattgc agtaaataca atgagtcaag atgtttacat aaagggaaag tccaatgtat     3120

taattgttca aagatgaacc gatatggatg gtgtgccata aaaatgagat gttttacaga     3180

ggaagaacag aaaaaagaac gtacatgcat taaatattat gcaaggagct ttaaaaaagc     3240

tcatgtaaag aagagtaaaa agaaaaaata atttatttat taatttaata ttgagagtgc     3300

cgacacagta tgcactaaaa aatatatctg tggtgtagtg agccgataca aaaggatagt     3360

cactcgcatt ttcataatac atcttatgtt atgattatgt gtcggtggga cttcacgacg     3420

aaaacccaca ataaaaaaag agttcggggt agggttaagc atagttgagg caactaaaca     3480

atcaagctag gatatgcagt agcagaccgt aaggtcgttg tttaggtgtg ttgtaataca     3540

tacgctatta agatgtaaaa atacggatac caatgaaggg aaaagtataa tttttggatg     3600

tagtttgttt gttcatctat gggcaaacta cgtccaaagc cgtttccaaa tctgctaaaa     3660

agtatatcct ttctaaaatc aaagtcaagt atgaaatcat aaataaagtt taattttgaa     3720

gttattatga tattatgttt ttctattaaa ataaattaag tatatagaat agtttaataa     3780

tagtatatac ttaatgtgat aagtgtctga cagtgtcaca gaaaggatga ttgttatgga     3840

ttataagcgg ctcgagtccc tatcagtgat agattgaaac tctatcattg atagagtata     3900

atatctttgt tcattagagc gataaacttg aatttgagag ggaacttcca tggataaaaa     3960

gtacagtatt ggtctagaca taggaactaa ctctgttggg tgggctgtta taacagatga     4020

atataaagtt ccatcaaaaa aatttaaagt attaggaaac actgatagac attcaataaa     4080

aaaaaacttg ataggtgctt tattattcga ttcaggagag actgctgaag ctacacgttt     4140

aaaaagaaca gctagacgta gatatacaag aagaaaaaat aggatatgtt atcttcaaga     4200

aatttttagt aatgaaatgg caaaagttga tgattcattc tttcacagac tagaagaaag     4260

tttcttagtt gaagaagata agaagcatga aagacaccct atttttggta atatcgtaga     4320

tgaagtagca tatcatgaga agtatccaac tatctatcat ttaagaaaga aattagttga     4380

ttctacagat aaagctgatc tgagattaat atatttagct ttagctcata tgattaaatt     4440

tagaggacat tttttaatag aaggtgattt aaacccagac aacagcgatg tagataaatt     4500

atttatccaa ttagttcaaa cttataatca attattcgaa gagaatccaa ttaatgcaag     4560

tggtgtagac gctaaggcta tattatcagc tagattatca aaatctagaa gattagaaaa     4620

tctaatagct caacttcctg gagaaaagaa aaatggactt tttgggaacc taatagctct     4680

ctcactcgga ctaacaccaa attttaaaag caattttgat cttgctgaag acgcaaagtt     4740

acaactatca aaggatacat acgatgatga tttagataat ttgttagctc aaataggtga     4800

tcaatatgct gatttgtttc ttgcagcaaa aaacttaagt gatgcaattt tactatcaga     4860

tatacttaga gtaaatacag aaataacaaa ggctccttta tcagcaagta tgattaaacg     4920

atatgatgag catcatcaag atttaacatt attaaaggca cttgtaagac aacaattacc     4980

agaaaaatat aaagaaattt tctttgatca atctaaaaat ggatatgctg gatatataga     5040

cggtggagca agtcaagaag agttttataa atttataaag cctattttag aaaaaatgga     5100

tggaactgaa gaattacttg ttaaacttaa cagagaagat ttacttagaa aacaaagaac     5160

ttttgataat ggttcaattc ctcaccaaat tcatttagga gaattacatg ctatactaag     5220

aagacaagaa gatttttatc catttcttaa agataataga gaaaaaattg aaaaaatttt     5280

aacttttaga ataccatatt atgtaggacc acttgcaagg ggaaattcaa gatttgcatg     5340

gatgactaga aaatcagaag aaactataac cccgtggaat tttgaagaag tagtagataa     5400

aggagctagt gctcaatcat ttatagaaag aatgacaaat tttgataaga atcttcctaa     5460

cgaaaaggtt ttgccaaagc atagccttct ttatgagtat tttacagttt ataatgagct     5520

tactaaagta aaatacgtta cagaaggaat gagaaaacca gcatttttgt ctggtgaaca     5580

aaagaaagca atagtagacc tattatttaa aacaaatagg aaggttaccg taaagcaact     5640

taaagaagat tacttcaaaa aaattgaatg ctttgatagt gttgaaatat caggagttga     5700

agatagattt aatgcttcac ttggtacata tcacgatctc ttaaaaatta taaaagataa     5760

ggatttttta gataatgaag aaaatgaaga tattcttgaa gatatagtat taacattgac     5820

actttttgaa gatagagaaa tgatagaaga aagattaaaa acatatgcac atctttttga     5880

tgataaggtt atgaagcaac ttaaaagaag aagatataca ggttggggac gtttgtcaag     5940

aaagctaatt aatggtatta gagataaaca atcaggaaag actattctcg attttcttaa     6000

atcagatgga tttgctaata gaaactttat gcaattaatt catgatgatt ctcttacttt     6060

caaagaggat attcaaaagg ctcaagtttc tggacaaggc gatagcttac acgaacacat     6120

tgctaacctt gcagggagcc ccgctatcaa aaaaggaatt ttacaaacag ttaaagttgt     6180

agatgaactt gttaaagtta tgggaagaca caaacctgag aatatagtta tagaaatggc     6240

cagagaaaat caaacaacac aaaaaggaca aaaaaattct agagagagaa tgaagagaat     6300

tgaagaagga ataaaagagc taggatcaca aatattaaaa gaacatccag ttgaaaatac     6360

tcaattgcaa aatgaaaagt tatatttgta ttacttacaa aatggaagag atatgtatgt     6420

tgatcaagaa ctcgatatta atagattaag tgactatgat gttgatcata ttgttcctca     6480

atcattttta aaagatgatt caatcgataa caaagtatta actagatcag ataaaaatag     6540

aggaaagtca gataatgtac catctgaaga agttgttaaa aaaatgaaga actattggag     6600

acaactttta aatgcaaagc taattacaca aagaaaattt gacaatttaa caaaagcaga     6660

aagaggagga ttaagcgaat tagacaaagc tggatttata aaaagacaac ttgttgagac     6720

aagacaaata actaagcatg ttgctcaaat acttgattca agaatgaata caaaatatga     6780

tgaaaatgat aaattaatca gagaagtaaa agtaataaca ttaaagtcaa aattagtatc     6840

agatttcaga aaggattttc aattttacaa agttcgtgaa ataaataact atcatcatgc     6900

tcatgatgca tacttaaatg ctgttgtagg aactgctctt attaagaaat atcctaaact     6960

agaaagcgaa tttgtttatg gagattataa agtttatgat gtgcgcaaaa tgatcgcgaa     7020

atccgaacaa gaaatcggta aggctacagc aaaatatttc ttttatagta atataatgaa     7080

tttttttaag acagaaataa ctttggctaa tggtgaaatc agaaaaagac cacttatcga     7140

aacaaatgga gagacaggag aaatagtatg ggataaagga agagattttg ctactgttag     7200

aaaagtacta agtatgccac aagtaaatat cgtaaagaaa actgaagttc aaactggagg     7260

tttctctaag gaatcaattt tacctaagag aaattcagat aagttaattg caaggaaaaa     7320

agattgggac ccaaaaaaat acggtggttt tgatagtcca acagttgcct atagtgttct     7380

tgtagtagcg aaagttgaga aaggtaagtc aaaaaagttg aaaagcgtaa aagaacttct     7440

tggtatcaca attatggaaa gatcttcatt tgaaaaaaat ccaattgact ttttagaagc     7500

taagggttat aaagaagtta aaaaggattt aatcataaaa ctaccaaagt atagtctatt     7560

tgaactcgaa aacggaagaa aacgaatgct cgctagcgca ggagaacttc aaaaaggaaa     7620

tgaacttgcg ctgccatcaa agtatgtaaa tttcttatat ttagcttctc attatgagaa     7680

attaaaagga tcaccagagg ataatgaaca aaagcaacta tttgtagaac aacacaaaca     7740

ttatttagat gaaataatag aacaaatatc tgaattttct aaaagagtta tacttgccga     7800

cgcaaatcta gataaggtgc tttcagcgta taataaacac agagataaac caataagaga     7860

acaagcagaa aacattatcc atctttttac attaactaat cttggtgcac cagctgcatt     7920

taagtacttt gatacaacaa tagatagaaa aagatacaca tctactaaag aagtattaga     7980

cgcaacttta atacatcaat ctattacagg gctttatgaa acaagaattg atttaagtca     8040

actaggcgga gattaagtcg acaaagtatt gttaaaaata actctgtaga attataaatt     8100

agttctacag agttattttt tgacccgggt atattgataa aaataataat agtgggtata     8160

attaagttgt taggaggtta gttagaatga tgtcaagatt agataaaagt aaagtgatta     8220

acagcgcatt agagctgctt aatgaggtcg gaatcgaagg tttaacaacc cgtaaactcg     8280

cccagaagct aggtgtagag cagcctacat tgtattggca tgtaaaaaat aagcgggctt     8340

tgctcgacgc cttagccatt gagatgttag ataggcacca tactcacttt tgccctttag     8400

aaggggaaag ctggcaagat tttttacgta ataacgctaa aagttttaga tgtgctttac     8460

taagtcatcg cgatggagca aaagtacatt taggtacacg gcctacagaa aaacagtatg     8520

aaactctcga aaatcaatta gcctttttat gccaacaagg tttttcacta gagaatgcat     8580

tatatgcact cagcgctgtg gggcatttta ctttaggttg cgtattggaa gatcaagagc     8640

atcaagtcgc taaagaagaa agggaaacac ctactactga tagtatgccg ccattattac     8700

gacaagctat cgaattattt gatcaccaag gtgcagagcc agccttctta ttcggccttg     8760

aattgatcat atgcggatta gaaaaacaac ttaaatgtga aagtgggtct taaaagcagc     8820

ataacctttt tccgtgatgg taacttcacg gtaaccaaga tgtcgagttg agctcttagt     8880

tcaactcact ttttaaggtg attgtttgca tgtcattata aaattcttct tcatcctcgt     8940

attcttgatt ccaaccgttt ttaaatgcag atatgaattt ttcaactatt gattcatttt     9000

cactttcaga aattacatac tcgtttccat cattattaac tctaataatt agctgtgtta     9060

tactattgct atccgtacca ctcaatttca ctgtgtaatc tttgtttttt atttctctaa     9120

ttaagtcatt aatattcatt tcagccctcc tgtgaaattg ttatccgctc acaattccac     9180

gtcgactacc gcggattcta gattctgcag tatcttcatg gtattcattt tttaatatca     9240

ttttaccctc ccaatacatt taaaataatt atgtattcat gaaacatgat tgtatattta     9300

agaaacataa ttccatataa atcatttttc aaaatagttt ttacccataa ttaaatgtta     9360

atatgtaaat taatctttta gaatagttaa aaagttctaa aatatgttat aatgtttctt     9420

ataatcttat aaattttaat aactaatata taaagatatt tctttaaaat attcttatat     9480

ttagaagaat ttattttaaa ataaaaagct tttatgttga taaactgctt tgcaaagctc     9540

tcatgtaaat gtttaatata agactactat aaaattggct aattttatag gttaggaggt     9600

agaaatgcaa atattgtgga aaaagtatgt taaagaaaac tttgaaatga atgtagatga     9660

atgtggtata gaacaaggta taccaggatt aggatataac tatgaagtat tgaaaaatgc     9720

tgttattcat tacgtaacta agggatatgg aacttttaaa tttaatggta aggtatataa     9780

cttaaaacaa ggtgatattt ttatactact aaaaggtatg caagttgagt atgtggcttc     9840

tattgatgat ccttgggaat actactggat aggatttagt ggttcaaatg ctaatgagta     9900

tttaaataga acttctatta ctaactcctg tgttgctaat tgtgaagaaa actcaaaaat     9960

tccacagata atattaaata tgtgcgaaat atcaaaaact tataatcctt caagatctga    10020

tgacatacta ttactaaaag aactttactc attattgtac gcacttatag aagaattccc    10080

aaaacctttt gaatacaaag ataaggaatt acacacatat attcaagatg ctcttaattt    10140

cattaattct aattacatgc atagcataac tgttcaagaa attgctgatt atgtgaactt    10200

aagtagaagt tatttatata aaatgttcat aaaaaacctt ggaatttctc ctcaaagata    10260

tttaataaac cttagaatgt acaaagccac ccttttatta aaaagcacta aacttcctat    10320

aggagaagtc gcaagtagtg taggttatag tgactccctg ttattttcaa aaactttttc    10380

aaaacatttt tcaatgtctc cactaaatta cagaaataat caagtaaata aaccaagtat    10440

ataaatttaa aatacagctt taaaacaaaa aaatttcaaa aataaaaagt ataacagagg    10500

cgtaaattaa aacctctgtt atactttttg agct                                10534


<210>  24
<211>  5754
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEC750S-uppHR

<400>  24
ataaggtacc aggaattaga gcagcgctat gttcagatac atttagtgct catgcaacaa       60

gagaacataa taatgctaat atattaacta tgggtcaaag ggttgttgga gcaggtcttg      120

ctttagatat agtaaaaaca tttatatcag ctaaatttga aggagatagg caccaaaaaa      180

gaatagataa gatttcagat attgaaaaaa agtatacaca ttagaaaaaa gcagctatgc      240

tgcaaataag atcaatttat attagaaaaa agcagctatg ctgcaaataa gatcaattta      300

tattagaaaa aagcagctat gctgcaaata agatcaattt atattagaaa aaagcagcta      360

tgctacaaat aagatcaatt tatattagaa aaaagtagct atgctgcaac aatattaatt      420

tatattacta gaaagctaaa tggggtatat aaatataaag ggctataaat actaaaagca      480

aacttggagg aataataatg gtctagagct ggagatagat tatttggtac taagtaatta      540

gtaatctatt agaattaaaa gctatctaca taagtttctg aatgacccaa gataatttta      600

ctggggggaa tatagaaaat ggagagacga gataagaaaa attattactt ggatattgct      660

gaaacagttt tagagagagg aacctgtcta aggagaaact atggttctat aattgttaaa      720

aatgatgaaa taatttctac tggatacaca ggagcaccta gaggtagaaa aaattgcatg      780

gatttgaata gttgcataag agaaaagttg aaagttccaa gaggtactca ttatgagttg      840

tgtaggagtg tacatagtga agctaatgca ataataagcg cttcgagctc gaattcgtaa      900

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata      960

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     1020

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     1080

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     1140

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     1200

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     1260

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     1320

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     1380

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     1440

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     1500

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     1560

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     1620

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     1680

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     1740

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     1800

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     1860

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     1920

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     1980

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     2040

atatatgagt aaacttggtc tgacagttac caaagctagc ttaatactag tatatactta     2100

atgtgataag tgtctgacag ctgaccggtc taaagaggtc cgccaatgaa atctataaat     2160

aaactaaatt aagtttattt aattaacaac tatggatata aaataggtac taatcaaaat     2220

agtgaggagg atatatttga atacatacga acaaattaat aaagtgaaaa aaatacttcg     2280

gaaacattta aaaaataacc ttattggtac ttacatgttt ggatcaggag ttgagagtgg     2340

actaaaacca aatagtgatc ttgacttttt agtcgtcgta tctgaaccat tgacagatca     2400

aagtaaagaa atacttatac aaaaaattag acctatttca aagaaaatag gagataaaag     2460

caacttacga tatattgaat taacaattat tattcagcaa gaaatggtac cgtggaatca     2520

tcctcccaaa caagaattta tttatggaga atggttacaa gagctttatg aacaaggata     2580

cattcctcag aaggaattaa attcagattt aaccataatg ctttaccaag caaaacgaaa     2640

aaataaaaga atatacggaa attatgactt agaggaatta ctacctgata ttccattttc     2700

tgatgtgaga agagccatta tggattcgtc agaggaatta atagataatt atcaggatga     2760

tgaaaccaac tctatattaa ctttatgccg tatgatttta actatggaca cgggtaaaat     2820

cataccaaaa gatattgcgg gaaatgcagt ggctgaatct tctccattag aacataggga     2880

gagaattttg ttagcagttc gtagttatct tggagagaat attgaatgga ctaatgaaaa     2940

tgtaaattta actataaact atttaaataa cagattaaaa aaattataaa aaaattgaaa     3000

aaatggtgga aacacttttt tcaatttttt tgttttatta tttaatattt gggaaatatt     3060

cattctaatt ggtaatcaga ttttagaagt tgttaacttc aggtttgtct gtaactaaaa     3120

actagtattt aacctaggat caaaaaaatt tccaataatc ccactctaag ccacaaacac     3180

gccctataaa atcccgcttt aatcccactt tgagacacat gtaatattac tttacgccct     3240

agtatagtga taatttttta cattcaatgc cacgcaaaaa aataaagggg cactataata     3300

aaagttcctt cggaactaac taaagtaaaa aattatcttt acaacctccc caaaaaaaag     3360

aacaggtaca aagtacccta taatacaagc gtaaaaaaaa tgagggtaaa aataaaaaaa     3420

taaaaaaata aaaaaataaa aaaataaaaa aataaaaaaa taaaaaaata taaaaataaa     3480

aaaatataaa aataaaaaaa tataaaaata aaaaaataaa aaaatataaa aataaaaaaa     3540

taaaaaaata taaaaatatt ttttatttaa agtttgaaaa aaattttttt atattatata     3600

atctttgaag aaaagaatat aaaaaatgag cctttataaa agcccatttt ttttcatata     3660

cgtaatatga cgttctaatg tttttattgg tacttctaac attagagtaa tttctttatt     3720

tttaaagcct ttttctttaa gggcttttat tttttttctt aatacattta attcctcttt     3780

ttttgttgct tttcctttag cttttaattg ctcttgataa ttttttttac ctctaatatt     3840

ttctcttctc ttatattcct ttttagaaat tattattgtc atatattttt gttcttcttc     3900

tgtaatttct aataactcta taagagtttc attcttatac ttatattgct tatttttatc     3960

taaataacat ctttcagcac ttctagttgc tcttataact tctctttcac ttaaatgttg     4020

tctaaacata ctattaagtt ctaaaacatc atttaatgcc ttctcaatgt cttctgtaaa     4080

gctacaaaga taatatctat ataaaaataa tataagctct ctgtgtcctt ttaaatcata     4140

ttctcttagt tcacaaagtt ttattatgtc ttgtattctt ccataatata aacttctttc     4200

tctataaata taatttattt tgcttggtct accctttttc ctttcatatg gttttaattc     4260

aggtaaaaat ccattttgta tttctcttaa gtcataaata tattcgtact catctaatat     4320

attgactact gtttttgatt tagagtttat acttcctgga actcttaata ttctcgttgc     4380

atctaaggct tgtctatctg ctccaaagta ttttaattga ttatataaat attcttgaac     4440

cgctttccat aatggtaatg ctttactagg tactgcattt attatccata ttaaatacat     4500

tcctcttcca ctatctatta catagtttgg tataggaata ctttgattaa aataattctt     4560

ttctaagtcc attaatacct ggtctttagt tttgccagtt ttataataat ccaagtctat     4620

aaacagtgta tttaactctt ttatattttc taatcgccta cacggcttat aaaaggtatt     4680

tagagttata tagatatttt catcactcat atctaaatct tttaattcag cgtatttata     4740

gtgccattgg ctatatcctt ttttatctat aacgctcctg gttatccacc ctttacttct     4800

actatgaata ttatctatat agttcttttt attcagcttt aatgcgtttc tcacttattc     4860

acctcccctt ctgtaaaact aagaaaatta tatcatattt tcaataatta ttaactattc     4920

ttaaactctt aataaaaaat agagtaagtc cccaattgaa acttaatcta ttttttatgt     4980

tttaatttat tatttttatt aaaatatttt aaactaaatt aaatgattct ttttaatttt     5040

ttactatttc attccataat atattactat aattatttac aaataatatt tcttcatttg     5100

taatatttag atgatttact aattttagtt tttatatatt aaataattaa tgtataattt     5160

atataaaaaa tcaaaggagc ttataaatta tgattatttc caaagatact aaagatttaa     5220

tttttttcaa ttttaacaat actttttgta atattatgtt taaatttaat tgtatttttt     5280

tcatataata aagccgttga agtaaaccaa tccattttcc ttatgatgtt attattaaat     5340

ttaagtttta taataatatc tttattatat ttattgtttt taaaaaaact agtgaaattt     5400

ctagtgaaat ttccggcttt attaaactta tttttaggaa ttttattttc attttcatct     5460

ttacaggatt tgattatatc tttaaatatg ttttatcaaa tattatcttt ttctaaattt     5520

atatatattt ttattatatt tattattata tatattttat ttttaagttt ctttctaaca     5580

gctattaaaa agaaacttaa aaataaaaac acgtactcta aaccaataaa taaaactatt     5640

tttattattg ctgccttgat tggaatagtt tttagtaaaa ttaatttcaa tattccacaa     5700

tattatatta taagctagca ggcctcgaga tctccatgga cgcgtgacgt cgac           5754


<210>  25
<211>  884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matrice de rparation

<400>  25
ataaggtacc aggaattaga gcagcgctat gttcagatac atttagtgct catgcaacaa       60

gagaacataa taatgctaat atattaacta tgggtcaaag ggttgttgga gcaggtcttg      120

ctttagatat agtaaaaaca tttatatcag ctaaatttga aggagatagg caccaaaaaa      180

gaatagataa gatttcagat attgaaaaaa agtatacaca ttagaaaaaa gcagctatgc      240

tgcaaataag atcaatttat attagaaaaa agcagctatg ctgcaaataa gatcaattta      300

tattagaaaa aagcagctat gctgcaaata agatcaattt atattagaaa aaagcagcta      360

tgctacaaat aagatcaatt tatattagaa aaaagtagct atgctgcaac aatattaatt      420

tatattacta gaaagctaaa tggggtatat aaatataaag ggctataaat actaaaagca      480

aacttggagg aataataatg gtctagagct ggagatagat tatttggtac taagtaatta      540

gtaatctatt agaattaaaa gctatctaca taagtttctg aatgacccaa gataatttta      600

ctggggggaa tatagaaaat ggagagacga gataagaaaa attattactt ggatattgct      660

gaaacagttt tagagagagg aacctgtcta aggagaaact atggttctat aattgttaaa      720

aatgatgaaa taatttctac tggatacaca ggagcaccta gaggtagaaa aaattgcatg      780

gatttgaata gttgcataag agaaaagttg aaagttccaa gaggtactca ttatgagttg      840

tgtaggagtg tacatagtga agctaatgca ataataagcg cttc                       884


<210>  26
<211>  500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment amont gne upp

<400>  26
ataaggtacc aggaattaga gcagcgctat gttcagatac atttagtgct catgcaacaa       60

gagaacataa taatgctaat atattaacta tgggtcaaag ggttgttgga gcaggtcttg      120

ctttagatat agtaaaaaca tttatatcag ctaaatttga aggagatagg caccaaaaaa      180

gaatagataa gatttcagat attgaaaaaa agtatacaca ttagaaaaaa gcagctatgc      240

tgcaaataag atcaatttat attagaaaaa agcagctatg ctgcaaataa gatcaattta      300

tattagaaaa aagcagctat gctgcaaata agatcaattt atattagaaa aaagcagcta      360

tgctacaaat aagatcaatt tatattagaa aaaagtagct atgctgcaac aatattaatt      420

tatattacta gaaagctaaa tggggtatat aaatataaag ggctataaat actaaaagca      480

aacttggagg aataataatg                                                  500


<210>  27
<211>  377
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment aval gne upp

<400>  27
gctggagata gattatttgg tactaagtaa ttagtaatct attagaatta aaagctatct       60

acataagttt ctgaatgacc caagataatt ttactggggg gaatatagaa aatggagaga      120

cgagataaga aaaattatta cttggatatt gctgaaacag ttttagagag aggaacctgt      180

ctaaggagaa actatggttc tataattgtt aaaaatgatg aaataatttc tactggatac      240

acaggagcac ctagaggtag aaaaaattgc atggatttga atagttgcat aagagaaaag      300

ttgaaagttc caagaggtac tcattatgag ttgtgtagga gtgtacatag tgaagctaat      360

gcaataataa gcgcttc                                                     377


<210>  28
<211>  2666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEX-A2-gRNA-upp

<400>  28
ctcgagtatt tttgataaaa gcaatgatta acatggtttg acgtctgaga agagacgatt       60

ttctcaatag gagaaattaa ggtgcaaacc cttatcattc caccatgatc cacctgtagc      120

aagcatgttt tagagctaga aatagcaagt taaaataagg ctagtccgtt atcaacttga      180

aaaagtggca ccgagtcggt gctttttttg ccatggacct gcttttgctc gcttggatcc      240

gaattcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca      300

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct      360

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac      420

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc      480

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt      540

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg      600

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg      660

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat      720

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta      780

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct      840

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc      900

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa      960

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg     1020

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag     1080

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt     1140

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta     1200

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc     1260

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca     1320

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa     1380

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat     1440

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct     1500

taccatctgg ccccagtgct gcaatgatac cgcgactccc acgctcaccg gctccagatt     1560

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat     1620

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta     1680

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg     1740

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt     1800

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg     1860

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg     1920

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc     1980

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa     2040

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac     2100

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt     2160

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg     2220

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa     2280

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata     2340

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca     2400

ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc     2460

gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt     2520

gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg     2580

ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccaat     2640

tgggtaccga gctcgcggcc gcaagc                                          2666


<210>  29
<211>  203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cassette d'expression d'un ARNg

<400>  29
tatttttgat aaaagcaatg attaacatgg tttgacgtct gagaagagac gattttctca       60

ataggagaaa ttaaggtgca aacccttatc attccaccat gatccacctg tagcaagcat      120

gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt      180

ggcaccgagt cggtgctttt ttt                                              203


<210>  30
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoteur constitutif

<400>  30
tatttttgat aaaagcaatg attaacatgg tttgacgtct gagaagagac gattttctca       60

ataggagaaa ttaaggtgca aacccttatc attccaccat                            100


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protospacer ciblant upp

<400>  31
gatccacctg tagcaagcat                                                   20


<210>  32
<211>  5954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEC750S-deltaupp

<400>  32
ataaggtacc aggaattaga gcagcgctat gttcagatac atttagtgct catgcaacaa       60

gagaacataa taatgctaat atattaacta tgggtcaaag ggttgttgga gcaggtcttg      120

ctttagatat agtaaaaaca tttatatcag ctaaatttga aggagatagg caccaaaaaa      180

gaatagataa gatttcagat attgaaaaaa agtatacaca ttagaaaaaa gcagctatgc      240

tgcaaataag atcaatttat attagaaaaa agcagctatg ctgcaaataa gatcaattta      300

tattagaaaa aagcagctat gctgcaaata agatcaattt atattagaaa aaagcagcta      360

tgctacaaat aagatcaatt tatattagaa aaaagtagct atgctgcaac aatattaatt      420

tatattacta gaaagctaaa tggggtatat aaatataaag ggctataaat actaaaagca      480

aacttggagg aataataatg gtctagagct ggagatagat tatttggtac taagtaatta      540

gtaatctatt agaattaaaa gctatctaca taagtttctg aatgacccaa gataatttta      600

ctggggggaa tatagaaaat ggagagacga gataagaaaa attattactt ggatattgct      660

gaaacagttt tagagagagg aacctgtcta aggagaaact atggttctat aattgttaaa      720

aatgatgaaa taatttctac tggatacaca ggagcaccta gaggtagaaa aaattgcatg      780

gatttgaata gttgcataag agaaaagttg aaagttccaa gaggtactca ttatgagttg      840

tgtaggagtg tacatagtga agctaatgca ataataagcg cttcgagctc gaattcgtaa      900

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata      960

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     1020

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     1080

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     1140

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     1200

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     1260

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     1320

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     1380

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     1440

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     1500

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     1560

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     1620

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     1680

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     1740

actagaagaa cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     1800

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     1860

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     1920

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     1980

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     2040

atatatgagt aaacttggtc tgacagttac caaagctagc ttaatactag tatatactta     2100

atgtgataag tgtctgacag ctgaccggtc taaagaggtc cgccaatgaa atctataaat     2160

aaactaaatt aagtttattt aattaacaac tatggatata aaataggtac taatcaaaat     2220

agtgaggagg atatatttga atacatacga acaaattaat aaagtgaaaa aaatacttcg     2280

gaaacattta aaaaataacc ttattggtac ttacatgttt ggatcaggag ttgagagtgg     2340

actaaaacca aatagtgatc ttgacttttt agtcgtcgta tctgaaccat tgacagatca     2400

aagtaaagaa atacttatac aaaaaattag acctatttca aagaaaatag gagataaaag     2460

caacttacga tatattgaat taacaattat tattcagcaa gaaatggtac cgtggaatca     2520

tcctcccaaa caagaattta tttatggaga atggttacaa gagctttatg aacaaggata     2580

cattcctcag aaggaattaa attcagattt aaccataatg ctttaccaag caaaacgaaa     2640

aaataaaaga atatacggaa attatgactt agaggaatta ctacctgata ttccattttc     2700

tgatgtgaga agagccatta tggattcgtc agaggaatta atagataatt atcaggatga     2760

tgaaaccaac tctatattaa ctttatgccg tatgatttta actatggaca cgggtaaaat     2820

cataccaaaa gatattgcgg gaaatgcagt ggctgaatct tctccattag aacataggga     2880

gagaattttg ttagcagttc gtagttatct tggagagaat attgaatgga ctaatgaaaa     2940

tgtaaattta actataaact atttaaataa cagattaaaa aaattataaa aaaattgaaa     3000

aaatggtgga aacacttttt tcaatttttt tgttttatta tttaatattt gggaaatatt     3060

cattctaatt ggtaatcaga ttttagaagt tgttaacttc aggtttgtct gtaactaaaa     3120

actagtattt aacctaggat caaaaaaatt tccaataatc ccactctaag ccacaaacac     3180

gccctataaa atcccgcttt aatcccactt tgagacacat gtaatattac tttacgccct     3240

agtatagtga taatttttta cattcaatgc cacgcaaaaa aataaagggg cactataata     3300

aaagttcctt cggaactaac taaagtaaaa aattatcttt acaacctccc caaaaaaaag     3360

aacaggtaca aagtacccta taatacaagc gtaaaaaaaa tgagggtaaa aataaaaaaa     3420

taaaaaaata aaaaaataaa aaaataaaaa aataaaaaaa taaaaaaata taaaaataaa     3480

aaaatataaa aataaaaaaa tataaaaata aaaaaataaa aaaatataaa aataaaaaaa     3540

taaaaaaata taaaaatatt ttttatttaa agtttgaaaa aaattttttt atattatata     3600

atctttgaag aaaagaatat aaaaaatgag cctttataaa agcccatttt ttttcatata     3660

cgtaatatga cgttctaatg tttttattgg tacttctaac attagagtaa tttctttatt     3720

tttaaagcct ttttctttaa gggcttttat tttttttctt aatacattta attcctcttt     3780

ttttgttgct tttcctttag cttttaattg ctcttgataa ttttttttac ctctaatatt     3840

ttctcttctc ttatattcct ttttagaaat tattattgtc atatattttt gttcttcttc     3900

tgtaatttct aataactcta taagagtttc attcttatac ttatattgct tatttttatc     3960

taaataacat ctttcagcac ttctagttgc tcttataact tctctttcac ttaaatgttg     4020

tctaaacata ctattaagtt ctaaaacatc atttaatgcc ttctcaatgt cttctgtaaa     4080

gctacaaaga taatatctat ataaaaataa tataagctct ctgtgtcctt ttaaatcata     4140

ttctcttagt tcacaaagtt ttattatgtc ttgtattctt ccataatata aacttctttc     4200

tctataaata taatttattt tgcttggtct accctttttc ctttcatatg gttttaattc     4260

aggtaaaaat ccattttgta tttctcttaa gtcataaata tattcgtact catctaatat     4320

attgactact gtttttgatt tagagtttat acttcctgga actcttaata ttctcgttgc     4380

atctaaggct tgtctatctg ctccaaagta ttttaattga ttatataaat attcttgaac     4440

cgctttccat aatggtaatg ctttactagg tactgcattt attatccata ttaaatacat     4500

tcctcttcca ctatctatta catagtttgg tataggaata ctttgattaa aataattctt     4560

ttctaagtcc attaatacct ggtctttagt tttgccagtt ttataataat ccaagtctat     4620

aaacagtgta tttaactctt ttatattttc taatcgccta cacggcttat aaaaggtatt     4680

tagagttata tagatatttt catcactcat atctaaatct tttaattcag cgtatttata     4740

gtgccattgg ctatatcctt ttttatctat aacgctcctg gttatccacc ctttacttct     4800

actatgaata ttatctatat agttcttttt attcagcttt aatgcgtttc tcacttattc     4860

acctcccctt ctgtaaaact aagaaaatta tatcatattt tcaataatta ttaactattc     4920

ttaaactctt aataaaaaat agagtaagtc cccaattgaa acttaatcta ttttttatgt     4980

tttaatttat tatttttatt aaaatatttt aaactaaatt aaatgattct ttttaatttt     5040

ttactatttc attccataat atattactat aattatttac aaataatatt tcttcatttg     5100

taatatttag atgatttact aattttagtt tttatatatt aaataattaa tgtataattt     5160

atataaaaaa tcaaaggagc ttataaatta tgattatttc caaagatact aaagatttaa     5220

tttttttcaa ttttaacaat actttttgta atattatgtt taaatttaat tgtatttttt     5280

tcatataata aagccgttga agtaaaccaa tccattttcc ttatgatgtt attattaaat     5340

ttaagtttta taataatatc tttattatat ttattgtttt taaaaaaact agtgaaattt     5400

ctagtgaaat ttccggcttt attaaactta tttttaggaa ttttattttc attttcatct     5460

ttacaggatt tgattatatc tttaaatatg ttttatcaaa tattatcttt ttctaaattt     5520

atatatattt ttattatatt tattattata tatattttat ttttaagttt ctttctaaca     5580

gctattaaaa agaaacttaa aaataaaaac acgtactcta aaccaataaa taaaactatt     5640

tttattattg ctgccttgat tggaatagtt tttagtaaaa ttaatttcaa tattccacaa     5700

tattatatta taagctagca cgcctcgagt atttttgata aaagcaatga ttaacatggt     5760

ttgacgtctg agaagagacg attttctcaa taggagaaat taaggtgcaa acccttatca     5820

ttccaccatg atccacctgt agcaagcatg ttttagagct agaaatagca agttaaaata     5880

aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt ttgccatgga     5940

cgcgtgacgt cgac                                                       5954


<210>  33
<211>  5853
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEC750C-deltaupp

<400>  33
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gtatttttga taaaagcaat gattaacatg gtttgacgtc tgagaagaga     2640

cgattttctc aataggagaa attaaggtgc aaacccttat cattccacca tgatccacct     2700

gtagcaagca tgttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa     2760

cttgaaaaag tggcaccgag tcggtgcttt ttttgccatg gacgcgtgac gtcgacataa     2820

ggtaccagga attagagcag cgctatgttc agatacattt agtgctcatg caacaagaga     2880

acataataat gctaatatat taactatggg tcaaagggtt gttggagcag gtcttgcttt     2940

agatatagta aaaacattta tatcagctaa atttgaagga gataggcacc aaaaaagaat     3000

agataagatt tcagatattg aaaaaaagta tacacattag aaaaaagcag ctatgctgca     3060

aataagatca atttatatta gaaaaaagca gctatgctgc aaataagatc aatttatatt     3120

agaaaaaagc agctatgctg caaataagat caatttatat tagaaaaaag cagctatgct     3180

acaaataaga tcaatttata ttagaaaaaa gtagctatgc tgcaacaata ttaatttata     3240

ttactagaaa gctaaatggg gtatataaat ataaagggct ataaatacta aaagcaaact     3300

tggaggaata ataatggtct agagctggag atagattatt tggtactaag taattagtaa     3360

tctattagaa ttaaaagcta tctacataag tttctgaatg acccaagata attttactgg     3420

ggggaatata gaaaatggag agacgagata agaaaaatta ttacttggat attgctgaaa     3480

cagttttaga gagaggaacc tgtctaagga gaaactatgg ttctataatt gttaaaaatg     3540

atgaaataat ttctactgga tacacaggag cacctagagg tagaaaaaat tgcatggatt     3600

tgaatagttg cataagagaa aagttgaaag ttccaagagg tactcattat gagttgtgta     3660

ggagtgtaca tagtgaagct aatgcaataa taagcgcttc gagctcgaat tcgtaatcat     3720

ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac aacatacgag     3780

ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc acattaattg     3840

cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg cattaatgaa     3900

tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct tcctcgctca     3960

ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac tcaaaggcgg     4020

taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga gcaaaaggcc     4080

agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat aggctccgcc     4140

cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac ccgacaggac     4200

tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct gttccgaccc     4260

tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg ctttctcata     4320

gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc     4380

acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     4440

acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg attagcagag     4500

cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac ggctacacta     4560

gaagaacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga aaaagagttg     4620

gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt gtttgcaagc     4680

agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt tctacggggt     4740

ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga ttatcaaaaa     4800

ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc taaagtatat     4860

atgagtaaac ttggtctgac agttaccaaa gctagcttaa tactagtata tacttaatgt     4920

gataagtgtc tgacagctga ccggtctaaa gaggtcccta gcgcctacgg ggaatttgta     4980

tcgataaggg gtacaaattc ccactaagcg ctcggccggg gatcgatccc cgggtacgta     5040

cccggcagtt tttctttttc ggcaagtgtt caagaagtta ttaagtcggg agtgcagtcg     5100

aagtgggcaa gttgaaaaat tcacaaaaat gtggtataat atctttgttc attagagcga     5160

taaacttgaa tttgagaggg aacttagatg gtatttgaaa aaattgataa aaatagttgg     5220

aacagaaaag agtattttga ccactacttt gcaagtgtac cttgtaccta cagcatgacc     5280

gttaaagtgg atatcacaca aataaaggaa aagggaatga aactatatcc tgcaatgctt     5340

tattatattg caatgattgt aaaccgccat tcagagttta ggacggcaat caatcaagat     5400

ggtgaattgg ggatatatga tgagatgata ccaagctata caatatttca caatgatact     5460

gaaacatttt ccagcctttg gactgagtgt aagtctgact ttaaatcatt tttagcagat     5520

tatgaaagtg atacgcaacg gtatggaaac aatcatagaa tggaaggaaa gccaaatgct     5580

ccggaaaaca tttttaatgt atctatgata ccgtggtcaa ccttcgatgg ctttaatctg     5640

aatttgcaga aaggatatga ttatttgatt cctattttta ctatggggaa atattataaa     5700

gaagataaca aaattatact tcctttggca attcaagttc atcacgcagt atgtgacgga     5760

tttcacattt gccgttttgt aaacgaattg caggaattga taaatagtta acttcaggtt     5820

tgtctgtaac taaaaactag tatttaacct agg                                  5853


<210>  34
<211>  4966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-pNF2

<400>  34
agctcggtac ccggggatcc tctagagtcg acgtcacgcg tccatggaga tctcgaggcg       60

tgctagctta taatataata ttgtggaata ttgaaattaa ttttactaaa aactattcca      120

atcaaggcag caataataaa aatagtttta tttattggtt tagagtacgt gtttttattt      180

ttaagtttct ttttaatagc tgttagaaag aaacttaaaa ataaaatata tataataata      240

aatataataa aaatatatat aaatttagaa aaagataata tttgataaaa catatttaaa      300

gatataatca aatcctgtaa agatgaaaat gaaaataaaa ttcctaaaaa taagtttaat      360

aaagccggaa atttcactag aaatttcact agttttttta aaaacaataa atataataaa      420

gatattatta taaaacttaa atttaataat aacatcataa ggaaaatgga ttggtttact      480

tcaacggctt tattatatga aaaaaataca attaaattta aacataatat tacaaaaagt      540

attgttaaaa ttgaaaaaaa ttaaatcttt agtatctttg gaaataatca taatttataa      600

gctcctttga ttttttatat aaattataca ttaattattt aatatataaa aactaaaatt      660

agtaaatcat ctaaatatta caaatgaaga aatattattt gtaaataatt atagtaatat      720

attatggaat gaaatagtaa aaaattaaaa agaatcattt aatttagttt aaaatatttt      780

aataaaaata ataaattaaa acataaaaaa tagattaagt ttcaattggg gacttactct      840

attttttatt aagagtttaa gaatagttaa taattattga aaatatgata taattttctt      900

agttttacag aaggggaggt gaataagtga gaaacgcatt aaagctgaat aaaaagaact      960

atatagataa tattcatagt agaagtaaag ggtggataac caggagcgtt atagataaaa     1020

aaggatatag ccaatggcac tataaatacg ctgaattaaa agatttagat atgagtgatg     1080

aaaatatcta tataactcta aatacctttt ataagccgtg taggcgatta gaaaatataa     1140

aagagttaaa tacactgttt atagacttgg attattataa aactggcaaa actaaagacc     1200

aggtattaat ggacttagaa aagaattatt ttaatcaaag tattcctata ccaaactatg     1260

taatagatag tggaagagga atgtatttaa tatggataat aaatgcagta cctagtaaag     1320

cattaccatt atggaaagcg gttcaagaat atttatataa tcaattaaaa tactttggag     1380

cagatagaca agccttagat gcaacgagaa tattaagagt tccaggaagt ataaactcta     1440

aatcaaaaac agtagtcaat atattagatg agtacgaata tatttatgac ttaagagaaa     1500

tacaaaatgg atttttacct gaattaaaac catatgaaag gaaaaagggt agaccaagca     1560

aaataaatta tatttataga gaaagaagtt tatattatgg aagaatacaa gacataataa     1620

aactttgtga actaagagaa tatgatttaa aaggacacag agagcttata ttatttttat     1680

atagatatta tctttgtagc tttacagaag acattgagaa ggcattaaat gatgttttag     1740

aacttaatag tatgtttaga caacatttaa gtgaaagaga agttataaga gcaactagaa     1800

gtgctgaaag atgttattta gataaaaata agcaatataa gtataagaat gaaactctta     1860

tagagttatt agaaattaca gaagaagaac aaaaatatat gacaataata atttctaaaa     1920

aggaatataa gagaagagaa aatattagag gtaaaaaaaa ttatcaagag caattaaaag     1980

ctaaaggaaa agcaacaaaa aaagaggaat taaatgtatt aagaaaaaaa ataaaagccc     2040

ttaaagaaaa aggctttaaa aataaagaaa ttactctaat gttagaagta ccaataaaaa     2100

cattagaacg tcatattacg tatatgaaaa aaaatgggct tttataaagg ctcatttttt     2160

atattctttt cttcaaagat tatataatat aaaaaaattt ttttcaaact ttaaataaaa     2220

aatattttta tattttttta tttttttatt tttatatttt tttatttttt tatttttata     2280

tttttttatt tttatatttt tttattttta tattttttta tttttttatt tttttatttt     2340

tttatttttt tattttttta tttttttatt tttaccctca ttttttttac gcttgtatta     2400

tagggtactt tgtacctgtt cttttttttg gggaggttgt aaagataatt ttttacttta     2460

gttagttccg aaggaacttt tattatagtg cccctttatt tttttgcgtg gcattgaatg     2520

taaaaaatta tcactatact agggcgtaaa gtaatattac atgtgtctca aagtgggatt     2580

aaagcgggat tttatagggc gtgtttgtgg cttagagtgg gattattgga aatttttttg     2640

atcctaggtt aaatactagt ttttagttac agacaaacct gaagttaact atttatcaat     2700

tcctgcaatt cgtttacaaa acggcaaatg tgaaatccgt cacatactgc gtgatgaact     2760

tgaattgcca aaggaagtat aattttgtta tcttctttat aatatttccc catagtaaaa     2820

ataggaatca aataatcata tcctttctgc aaattcagat taaagccatc gaaggttgac     2880

cacggtatca tagatacatt aaaaatgttt tccggagcat ttggctttcc ttccattcta     2940

tgattgtttc cataccgttg cgtatcactt tcataatctg ctaaaaatga tttaaagtca     3000

gacttacact cagtccaaag gctggaaaat gtttcagtat cattgtgaaa tattgtatag     3060

cttggtatca tctcatcata tatccccaat tcaccatctt gattgattgc cgtcctaaac     3120

tctgaatggc ggtttacaat cattgcaata taataaagca ttgcaggata tagtttcatt     3180

cccttttcct ttatttgtgt gatatccact ttaacggtca tgctgtaggt acaaggtaca     3240

cttgcaaagt agtggtcaaa atactctttt ctgttccaac tatttttatc aattttttca     3300

aataccatct aagttccctc tcaaattcaa gtttatcgct ctaatgaaca aagatattat     3360

accacatttt tgtgaatttt tcaacttgcc cacttcgact gcactcccga cttaataact     3420

tcttgaacac ttgccgaaaa agaaaaactg ccgggtacgt acccggggat cgatccccgg     3480

ccgagcgctt agtgggaatt tgtacccctt atcgatacaa attccccgta ggcgctaggg     3540

acctctttag accggtcagc tgtcagacac ttatcacatt aagtatatac tagtattaag     3600

ctagctttgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     3660

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     3720

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     3780

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     3840

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     3900

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca     3960

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     4020

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     4080

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     4140

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     4200

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     4260

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     4320

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     4380

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     4440

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     4500

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     4560

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     4620

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     4680

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     4740

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgaattcg agctcactct     4800

atcattgata gagtttgaaa ctctatcatt gatagagtat aatatctttg ttcatttaag     4860

ccatctacta aacaagtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta     4920

tcaacttgaa aaagtggcac cgagtcggtg ctttttttga agcttg                    4966


<210>  35
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment amont du gne catB

<400>  35
gtctttacac ttttgcccat taatttttga gttccttatt tttagggagc ttttattatt       60

tttatcatga aaatttcata aaatactcat aaactaagga tgtcttcata atcagattag      120

tactccattt tcaatccatt taatctggga atatgatatt ttaattacgt attatttaag      180

atatattaac gtgtaatata ataccccgca aatattaatt atcacataca tatcccccct      240

ttattggggc attttttgta cccattattt tagtattgtg cagtacttaa ataaaaaaat      300

gccgcaaatt catttttatt gaataatgcg gtatttcttc tattctttat ttttattact      360

ctataaataa tgtaatcaag acatgactat ctaaatatat                            400


<210>  36
<211>  400
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Fragment aval du gne catB

<400>  36
aattcataat tcgggcctcc taaaaatttt cgtaattcta ttttagaagg cttttttccg       60

tgacctagcc atttcaatct cctttttaca atgatattta cgctttagtt tattatagca      120

cattctgtaa taccgaacta ttcaattttc agagaccatt ttttattgat tcataactta      180

agaatactac gaattactct aatattttac tttttcttat ctcttgttat tttaacatcg      240

gaattactac taatattaat ttttattttt ccatccgcat ttgctccaac atttttttaa      300

ctatactttc cttttgttaa taaattatgt tattgttgaa caatataaga aaagtgcgta      360

acatttttta ttaaaaataa ttaggtattt ctatctgtgg                            400


<210>  37
<211>  218
<212>  PRT
<213>  Clostridium beijerinckii

<400>  37

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Lys 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Asp His Glu Gly Ser Leu Gly Tyr Trp 
65                  70                  75                  80  


Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu Thr 
                85                  90                  95      


Phe Ser Ser Ile Trp Thr Glu Tyr Asn Lys Ser Phe Leu Arg Phe Tyr 
            100                 105                 110         


Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys Phe 
        115                 120                 125             


Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser Ile 
    130                 135                 140                 


Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu Gly 
145                 150                 155                 160 


Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln Glu 
                165                 170                 175     


Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile Cys 
            180                 185                 190         


Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu Ala 
        195                 200                 205             


Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215             


<210>  38
<211>  9113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCas9ind-gRNA_catB

<400>  38
catggataaa aagtacagta ttggtctaga cataggaact aactctgttg ggtgggctgt       60

tataacagat gaatataaag ttccatcaaa aaaatttaaa gtattaggaa acactgatag      120

acattcaata aaaaaaaact tgataggtgc tttattattc gattcaggag agactgctga      180

agctacacgt ttaaaaagaa cagctagacg tagatataca agaagaaaaa ataggatatg      240

ttatcttcaa gaaattttta gtaatgaaat ggcaaaagtt gatgattcat tctttcacag      300

actagaagaa agtttcttag ttgaagaaga taagaagcat gaaagacacc ctatttttgg      360

taatatcgta gatgaagtag catatcatga gaagtatcca actatctatc atttaagaaa      420

gaaattagtt gattctacag ataaagctga tctgagatta atatatttag ctttagctca      480

tatgattaaa tttagaggac attttttaat agaaggtgat ttaaacccag acaacagcga      540

tgtagataaa ttatttatcc aattagttca aacttataat caattattcg aagagaatcc      600

aattaatgca agtggtgtag acgctaaggc tatattatca gctagattat caaaatctag      660

aagattagaa aatctaatag ctcaacttcc tggagaaaag aaaaatggac tttttgggaa      720

cctaatagct ctctcactcg gactaacacc aaattttaaa agcaattttg atcttgctga      780

agacgcaaag ttacaactat caaaggatac atacgatgat gatttagata atttgttagc      840

tcaaataggt gatcaatatg ctgatttgtt tcttgcagca aaaaacttaa gtgatgcaat      900

tttactatca gatatactta gagtaaatac agaaataaca aaggctcctt tatcagcaag      960

tatgattaaa cgatatgatg agcatcatca agatttaaca ttattaaagg cacttgtaag     1020

acaacaatta ccagaaaaat ataaagaaat tttctttgat caatctaaaa atggatatgc     1080

tggatatata gacggtggag caagtcaaga agagttttat aaatttataa agcctatttt     1140

agaaaaaatg gatggaactg aagaattact tgttaaactt aacagagaag atttacttag     1200

aaaacaaaga acttttgata atggttcaat tcctcaccaa attcatttag gagaattaca     1260

tgctatacta agaagacaag aagattttta tccatttctt aaagataata gagaaaaaat     1320

tgaaaaaatt ttaactttta gaataccata ttatgtagga ccacttgcaa ggggaaattc     1380

aagatttgca tggatgacta gaaaatcaga agaaactata accccgtgga attttgaaga     1440

agtagtagat aaaggagcta gtgctcaatc atttatagaa agaatgacaa attttgataa     1500

gaatcttcct aacgaaaagg ttttgccaaa gcatagcctt ctttatgagt attttacagt     1560

ttataatgag cttactaaag taaaatacgt tacagaagga atgagaaaac cagcattttt     1620

gtctggtgaa caaaagaaag caatagtaga cctattattt aaaacaaata ggaaggttac     1680

cgtaaagcaa cttaaagaag attacttcaa aaaaattgaa tgctttgata gtgttgaaat     1740

atcaggagtt gaagatagat ttaatgcttc acttggtaca tatcacgatc tcttaaaaat     1800

tataaaagat aaggattttt tagataatga agaaaatgaa gatattcttg aagatatagt     1860

attaacattg acactttttg aagatagaga aatgatagaa gaaagattaa aaacatatgc     1920

acatcttttt gatgataagg ttatgaagca acttaaaaga agaagatata caggttgggg     1980

acgtttgtca agaaagctaa ttaatggtat tagagataaa caatcaggaa agactattct     2040

cgattttctt aaatcagatg gatttgctaa tagaaacttt atgcaattaa ttcatgatga     2100

ttctcttact ttcaaagagg atattcaaaa ggctcaagtt tctggacaag gcgatagctt     2160

acacgaacac attgctaacc ttgcagggag ccccgctatc aaaaaaggaa ttttacaaac     2220

agttaaagtt gtagatgaac ttgttaaagt tatgggaaga cacaaacctg agaatatagt     2280

tatagaaatg gccagagaaa atcaaacaac acaaaaagga caaaaaaatt ctagagagag     2340

aatgaagaga attgaagaag gaataaaaga gctaggatca caaatattaa aagaacatcc     2400

agttgaaaat actcaattgc aaaatgaaaa gttatatttg tattacttac aaaatggaag     2460

agatatgtat gttgatcaag aactcgatat taatagatta agtgactatg atgttgatca     2520

tattgttcct caatcatttt taaaagatga ttcaatcgat aacaaagtat taactagatc     2580

agataaaaat agaggaaagt cagataatgt accatctgaa gaagttgtta aaaaaatgaa     2640

gaactattgg agacaacttt taaatgcaaa gctaattaca caaagaaaat ttgacaattt     2700

aacaaaagca gaaagaggag gattaagcga attagacaaa gctggattta taaaaagaca     2760

acttgttgag acaagacaaa taactaagca tgttgctcaa atacttgatt caagaatgaa     2820

tacaaaatat gatgaaaatg ataaattaat cagagaagta aaagtaataa cattaaagtc     2880

aaaattagta tcagatttca gaaaggattt tcaattttac aaagttcgtg aaataaataa     2940

ctatcatcat gctcatgatg catacttaaa tgctgttgta ggaactgctc ttattaagaa     3000

atatcctaaa ctagaaagcg aatttgttta tggagattat aaagtttatg atgtgcgcaa     3060

aatgatcgcg aaatccgaac aagaaatcgg taaggctaca gcaaaatatt tcttttatag     3120

taatataatg aattttttta agacagaaat aactttggct aatggtgaaa tcagaaaaag     3180

accacttatc gaaacaaatg gagagacagg agaaatagta tgggataaag gaagagattt     3240

tgctactgtt agaaaagtac taagtatgcc acaagtaaat atcgtaaaga aaactgaagt     3300

tcaaactgga ggtttctcta aggaatcaat tttacctaag agaaattcag ataagttaat     3360

tgcaaggaaa aaagattggg acccaaaaaa atacggtggt tttgatagtc caacagttgc     3420

ctatagtgtt cttgtagtag cgaaagttga gaaaggtaag tcaaaaaagt tgaaaagcgt     3480

aaaagaactt cttggtatca caattatgga aagatcttca tttgaaaaaa atccaattga     3540

ctttttagaa gctaagggtt ataaagaagt taaaaaggat ttaatcataa aactaccaaa     3600

gtatagtcta tttgaactcg aaaacggaag aaaacgaatg ctcgctagcg caggagaact     3660

tcaaaaagga aatgaacttg cgctgccatc aaagtatgta aatttcttat atttagcttc     3720

tcattatgag aaattaaaag gatcaccaga ggataatgaa caaaagcaac tatttgtaga     3780

acaacacaaa cattatttag atgaaataat agaacaaata tctgaatttt ctaaaagagt     3840

tatacttgcc gacgcaaatc tagataaggt gctttcagcg tataataaac acagagataa     3900

accaataaga gaacaagcag aaaacattat ccatcttttt acattaacta atcttggtgc     3960

accagctgca tttaagtact ttgatacaac aatagataga aaaagataca catctactaa     4020

agaagtatta gacgcaactt taatacatca atctattaca gggctttatg aaacaagaat     4080

tgatttaagt caactaggcg gagattaagt cgacaaagta ttgttaaaaa taactctgta     4140

gaattataaa ttagttctac agagttattt tttgacccgg gtatattgat aaaaataata     4200

atagtgggta taattaagtt gttaggaggt tagttagaat gatgtcaaga ttagataaaa     4260

gtaaagtgat taacagcgca ttagagctgc ttaatgaggt cggaatcgaa ggtttaacaa     4320

cccgtaaact cgcccagaag ctaggtgtag agcagcctac attgtattgg catgtaaaaa     4380

ataagcgggc tttgctcgac gccttagcca ttgagatgtt agataggcac catactcact     4440

tttgcccttt agaaggggaa agctggcaag attttttacg taataacgct aaaagtttta     4500

gatgtgcttt actaagtcat cgcgatggag caaaagtaca tttaggtaca cggcctacag     4560

aaaaacagta tgaaactctc gaaaatcaat tagccttttt atgccaacaa ggtttttcac     4620

tagagaatgc attatatgca ctcagcgctg tggggcattt tactttaggt tgcgtattgg     4680

aagatcaaga gcatcaagtc gctaaagaag aaagggaaac acctactact gatagtatgc     4740

cgccattatt acgacaagct atcgaattat ttgatcacca aggtgcagag ccagccttct     4800

tattcggcct tgaattgatc atatgcggat tagaaaaaca acttaaatgt gaaagtgggt     4860

cttaaaagca gcataacctt tttccgtgat ggtaacttca cggtaaccaa gatgtcgagt     4920

tgagctcgaa ttcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca     4980

caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag     5040

tgagctaact cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt     5100

cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc     5160

gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg     5220

tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa     5280

agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg     5340

cgtttttcca taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga     5400

ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg     5460

tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg     5520

gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc     5580

gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg     5640

gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca     5700

ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt     5760

ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag     5820

ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg     5880

gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc     5940

ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt     6000

tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt     6060

ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccag gtccactgcc     6120

gggcctcttg cgggatcaaa agaaaaacga aatgatacac caatcagtgc aaaaaaagat     6180

ataatgggag ataagacggt tcgtgttcgt gctgacttgc accatatcat aaaaatcgaa     6240

acagcaaaga atggcggaaa cgtaaaagaa gttatggaaa taagacttag aagcaaactt     6300

aagagtgtgt tgatagtgca gtatcttaaa attttgtata ataggaattg aagttaaatt     6360

agatgctaaa aatttgtaat taagaaggag tgattacatg aacaaaaata taaaatattc     6420

tcaaaacttt ttaacgagtg aaaaagtact caaccaaata ataaaacaat tgaatttaaa     6480

agaaaccgat accgtttacg aaattggaac aggtaaaggg catttaacga cgaaactggc     6540

taaaataagt aaacaggtaa cgtctattga attagacagt catctattca acttatcgtc     6600

agaaaaatta aaactgaata ctcgtgtcac tttaattcac caagatattc tacagtttca     6660

attccctaac aaacagaggt ataaaattgt tgggagtatt ccttaccatt taagcacaca     6720

aattattaaa aaagtggttt ttgaaagcca tgcgtctgac atctatctga ttgttgaaga     6780

aggattctac aagcgtacct tggatattca ccgaacacta gggttgctct tgcacactca     6840

agtctcgatt cagcaattgc ttaagctgcc agcggaatgc tttcatccta aaccaaaagt     6900

aaacagtgtc ttaataaaac ttacccgcca taccacagat gttccagata aatattggaa     6960

gctatatacg tactttgttt caaaatgggt caatcgagaa tatcgtcaac tgtttactaa     7020

aaatcagttt catcaagcaa tgaaacacgc caaagtaaac aatttaagta ccgttactta     7080

tgagcaagta ttgtctattt ttaatagtta tctattattt aacgggagga aataattcta     7140

tgagtcccta ggcaggcctc cgccattatt tttttgaaca attgacaatt catttcttat     7200

tttttattaa gtgatagtca aaaggcataa cagtgctgaa tagaaagaaa tttacagaaa     7260

agaaaattat agaatttagt atgattaatt atactcattt atgaatgttt aattgaatac     7320

aaaaaaaaat acttgttatg tattcaatta cgggttaaaa tatagacaag ttgaaaaatt     7380

taataaaaaa ataagtcctc agctcttata tattaagcta ccaacttagt atataagcca     7440

aaacttaaat gtgctaccaa cacatcaagc cgttagagaa ctctatctat agcaatattt     7500

caaatgtacc gacatacaag agaaacatta actatatata ttcaatttat gagattatct     7560

taacagatat aaatgtaaat tgcaataagt aagatttaga agtttatagc ctttgtgtat     7620

tggaagcagt acgcaaaggc ttttttattt gataaaaatt agaagtatat ttattttttc     7680

ataattaatt tatgaaaatg aaagggggtg agcaaagtga cagaggaaag cagtatctta     7740

tcaaataaca aggtattagc aatatcatta ttgactttag cagtaaacat tatgactttt     7800

atagtgcttg tagctaagta gtacgaaagg gggagcttta aaaagctcct tggaatacat     7860

agaattcata aattaattta tgaaaagaag ggcgtatatg aaaacttgta aaaattgcaa     7920

agagtttatt aaagatactg aaatatgcaa aatacattcg ttgatgattc atgataaaac     7980

agtagcaacc tattgcagta aatacaatga gtcaagatgt ttacataaag ggaaagtcca     8040

atgtattaat tgttcaaaga tgaaccgata tggatggtgt gccataaaaa tgagatgttt     8100

tacagaggaa gaacagaaaa aagaacgtac atgcattaaa tattatgcaa ggagctttaa     8160

aaaagctcat gtaaagaaga gtaaaaagaa aaaataattt atttattaat ttaatattga     8220

gagtgccgac acagtatgca ctaaaaaata tatctgtggt gtagtgagcc gatacaaaag     8280

gatagtcact cgcattttca taatacatct tatgttatga ttatgtgtcg gtgggacttc     8340

acgacgaaaa cccacaataa aaaaagagtt cggggtaggg ttaagcatag ttgaggcaac     8400

taaacaatca agctaggata tgcagtagca gaccgtaagg tcgttgttta ggtgtgttgt     8460

aatacatacg ctattaagat gtaaaaatac ggataccaat gaagggaaaa gtataatttt     8520

tggatgtagt ttgtttgttc atctatgggc aaactacgtc caaagccgtt tccaaatctg     8580

ctaaaaagta tatcctttct aaaatcaaag tcaagtatga aatcataaat aaagtttaat     8640

tttgaagtta ttatgatatt atgtttttct attaaaataa attaagtata tagaatagtt     8700

taataatagt atatacttaa tgtgataagt gtctgacagt gtcacagaaa ggatgattgt     8760

tatggattat aagcggctcg aggacgtcaa accatgttaa tcattgcttt tatcaaaaat     8820

aggatccact ctatcattga tagagtttga aactctatca ttgatagagt ataatatctt     8880

tgttcatgta catcatgcta tctgtgagtt ttagagctag aaatagcaag ttaaaataag     8940

gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttt gaagcttgtc     9000

tttacacttt tgcccctcga gtccctatca gtgatagatt gaaactctat cattgataga     9060

gtataatatc tttgttcatt agagcgataa acttgaattt gagagggaac ttc            9113


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pNF2

<400>  39
gggcgcactt atacaccacc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pNF2

<400>  40
tgctacgcac cccctaaagg                                                   20


<210>  41
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DeltacatB_gRNA_rev

<400>  41
aatctatcac tgatagggac tcgaggggca aaagtgtaaa gacaagcttc                  50


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pCas9ind_fwd

<400>  42
agctcttgat ccggcaaaca                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Amorce pCas9ind _rev

<400>  43
gcaaccctag tgttcggtga                                                   20


<210>  44
<211>  219
<212>  PRT
<213>  Clostridium butyricum

<400>  44

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Lys Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  45
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  45

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ile Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Lys Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  46
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  46

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Glu Glu Phe Arg Ile Cys Phe Asp His Glu Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Lys Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Val Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  47
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  47

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Ser Ile Cys Phe Asp His Glu Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  48
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostridium sp.2-1

<400>  48

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Asn Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Asn Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Gln Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  49
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostridium diolis

<400>  49

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Asn Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Asn Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Val Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  50
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  50

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ile Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Lys Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Gln Pro Asp Asn Thr Phe Ser Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Asn Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Lys Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  51
<211>  221
<212>  PRT
<213>  Clostridium beijerinckii

<400>  51

Met Asn Phe Asn Leu Ile Asp Ile Asn Asn Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Asn Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Glu Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys Tyr Ile 
    210                 215                 220     


<210>  52
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  52

Met Asn Phe Asn Leu Ile Asp Ile Asn Asn Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Asn Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Arg Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  53
<211>  219
<212>  PRT
<213>  Clostridium saccharoperbutylacetonicum

<400>  53

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Thr Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Ile Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Ile Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  54
<211>  219
<212>  PRT
<213>  Clostridium saccharoperbutylacetonicum

<400>  54

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Thr Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe Tyr Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Ile Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Ile Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  55
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  55

Met Asn Phe Asn Leu Ile Asp Ile Asn Asn Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Asn Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Arg Ser Asp Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Gly Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Arg Glu Trp Leu Glu Asn Lys 
    210                 215                 


<210>  56
<211>  221
<212>  PRT
<213>  Clostridium beijerinckii

<400>  56

Met Asn Phe Asn Leu Ile Asp Ile Asn His Trp Asn Arg Lys Pro Phe 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Lys Leu Lys Asn Ile 
        35                  40                  45              


Lys Phe Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Ile Cys Phe Asp His Lys Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Ile Phe His Glu Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Leu Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Ser Asn Glu Pro Asp Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Cys Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Thr Pro Ile Phe Thr Ala Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Ile Phe Ile Pro Ile Ser Ile Gln Val His His Ser Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Glu Trp Leu Glu Asn Lys Tyr Ile 
    210                 215                 220     


<210>  57
<211>  219
<212>  PRT
<213>  Clostridium beijerinckii

<400>  57

Met Asn Phe Asn Leu Ile Asp Ile Lys His Trp Ser Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Asn Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asp Leu Leu Tyr Glu Ile Arg Leu Lys Asn Ile 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Met Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp His Ser Gly Ser Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asn Glu Ser Phe Pro Arg Phe 
            100                 105                 110         


Tyr Ser Asp Tyr Phe Asp Asp Ile Lys Asn Tyr Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Leu Asn Glu Pro Asp Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Glu 
145                 150                 155                 160 


Gly Thr Tyr Leu Ile Pro Ile Phe Thr Thr Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Glu Asn Lys Met Phe Ile Pro Ile Ser Ile Gln Val His His Ala Ile 
            180                 185                 190         


Cys Asp Gly Tyr His Ala Ser Arg Phe Ile Asn Glu Met Gln Glu Leu 
        195                 200                 205             


Ala Phe Ser Phe Gln Asp Trp Leu Glu Asn Lys 
    210                 215                 


<210>  58
<211>  219
<212>  PRT
<213>  Clostridium botulinum

<400>  58

Met Lys Phe Asn Leu Ile Asp Ile Glu His Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu Tyr Tyr Leu His Ser Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu His Glu Ile Lys Leu Lys Lys Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Glu Asn Gly Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Ile Phe His Lys Asp Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Asp Tyr Asp Glu Ser Phe Ser Cys Phe 
            100                 105                 110         


Tyr Asn Asp Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Ala Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Leu Asn Glu Pro Ala Asn Thr Phe Pro Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Asn Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Asn 
145                 150                 155                 160 


Gly Thr Tyr Leu Val Pro Ile Phe Thr Met Gly Lys Tyr Phe Glu Gln 
                165                 170                 175     


Asn Asn Lys Ile Phe Ile Pro Met Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Ile Ser Arg Phe Ile Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ala Leu Asn Ser Gln Thr Trp Leu Lys His Lys 
    210                 215                 


<210>  59
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anaerocolumna aminovalerica

<400>  59

Met Lys Phe Asn Leu Ile Asp Ile Glu Asn Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ser Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu His Glu Ile Lys Leu Lys Asp Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Leu Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Glu Asn Gly Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Ile Phe His Lys Glu Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Glu Ser Phe Ser Arg Phe 
            100                 105                 110         


Tyr Thr Ala Tyr Leu Asp Asp Ile Lys Asn His Gly Asn Ile Met Lys 
        115                 120                 125             


Phe Thr Pro Lys Leu Asn Glu Pro Ala Asn Thr Phe Pro Ile Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Asp 
145                 150                 155                 160 


Gly Lys Tyr Leu Leu Pro Ile Phe Thr Thr Gly Lys Tyr Phe Glu Gln 
                165                 170                 175     


Asn Ser Lys Ile Phe Ile Pro Met Ser Val Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Ile Ser Arg Phe Ile Asn Glu Val Gln Glu Val 
        195                 200                 205             


Ile Leu Asn Tyr Gln Thr Trp Leu Gly Asp Lys 
    210                 215                 


<210>  60
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Desnuesiella massiliensis

<400>  60

Met Lys Phe Asn Leu Ile Asp Ile Glu His Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ser Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu His Asp Ile Lys Leu Lys Lys Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Glu Glu Phe Arg Thr Cys Phe Tyr Glu Asn Gly Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Ile Phe His Lys Asp Asn Glu 
                85                  90                  95      


Thr Phe Ser Glu Ile Trp Ser Glu Tyr Asp Glu Ser Phe Ser Cys Phe 
            100                 105                 110         


Tyr Ser Lys Tyr Leu Asp Asp Ile Lys Asn Tyr Gly Asp Ile Met Arg 
        115                 120                 125             


Phe Thr Pro Lys Leu Asn Glu Pro Ala Asn Thr Phe Pro Ile Ser Cys 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Val Tyr Asn Asp 
145                 150                 155                 160 


Gly Arg Tyr Leu Val Pro Ile Phe Thr Ile Gly Lys Tyr Phe Glu Gln 
                165                 170                 175     


Asn Asn Lys Ile Phe Ile Pro Met Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Ile Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ala Leu Asn Ser Gln Thr Trp Leu Arg His Lys 
    210                 215                 


<210>  61
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostridium sp. HMP27

<400>  61

Met Lys Phe Asn Leu Ile Asp Thr Glu His Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ser Val Arg Cys Thr Tyr Ser Ile Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu His Asp Ile Lys Gln Lys Lys Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Phe Ile Tyr Ile Ile Ala Thr Val Val Asn Thr 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Glu Ser Gly Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Ile Phe His Lys Asp Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Lys Ser Phe Ser Cys Phe 
            100                 105                 110         


Tyr Ser Lys Tyr Leu His Asp Ile Lys Asn Tyr Gly Asp Ile Met Ser 
        115                 120                 125             


Phe Thr Pro Lys Leu Asn Glu Pro Ala Asn Thr Phe Pro Ile Ser Cys 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Ile Tyr Asn Asp 
145                 150                 155                 160 


Gly Thr Tyr Leu Val Pro Ile Phe Thr Ile Gly Lys Tyr Phe Lys Gln 
                165                 170                 175     


Ala Asp Lys Ile Leu Ile Pro Ile Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Ile Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ile Leu Asn Tyr Gln Thr Trp Leu Lys His Lys 
    210                 215                 


<210>  62
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostridium drakei

<400>  62

Met Lys Phe Asn Leu Ile Asp Ile Glu Asn Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ala Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Gly Leu Leu Arg Glu Ile Lys Leu Lys Gly Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Thr Ala Val Ile Asn Arg 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Glu Asn Arg Lys Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Val Phe His Lys Glu Asp Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Glu Ser Phe Pro Arg Phe 
            100                 105                 110         


Tyr Asp Asn Tyr Leu Asp Asp Ile Lys Ser Tyr Gly Asp Val Leu Lys 
        115                 120                 125             


Phe Met Pro Lys Pro Asp Glu Pro Gly Asn Thr Phe Asn Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Asn Phe Thr Gly Phe Asn Leu Asn Ile Tyr Asn Asp 
145                 150                 155                 160 


Ala Thr Tyr Leu Ile Pro Ile Phe Thr Met Gly Lys Phe Phe His Gln 
                165                 170                 175     


Asp Asn Lys Ile Phe Ile Pro Met Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Phe Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ser Ser Asn Phe Glu Thr Trp Leu Asp Glu Lys 
    210                 215                 


<210>  63
<211>  219
<212>  PRT
<213>  Clostridium scatologenes

<400>  63

Met Lys Phe Asn Leu Ile Asp Ile Glu Asp Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ala Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Gly Leu Leu Arg Glu Ile Lys Leu Lys Gly Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Thr Ala Val Ile Asn Arg 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Glu Asn Arg Lys Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Ser Tyr Thr Val Phe His Lys Glu Asp Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Glu Ser Phe Pro Arg Phe 
            100                 105                 110         


Tyr Asp Asn Tyr Leu Asp Asp Ile Lys Ser Tyr Gly Asp Val Leu Lys 
        115                 120                 125             


Phe Met Pro Lys Pro Asp Glu Pro Gly Asn Thr Phe Asn Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Asn Phe Thr Gly Phe Asn Leu Asn Ile Tyr Asn Asp 
145                 150                 155                 160 


Ala Thr Tyr Leu Ile Pro Ile Phe Thr Met Gly Lys Phe Phe His Gln 
                165                 170                 175     


Asp Asn Lys Ile Phe Ile Pro Met Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Phe Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ser Ser Asn Phe Glu Thr Trp Leu Gly Glu Lys 
    210                 215                 


<210>  64
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostridium tunisiense

<400>  64

Met Lys Phe Asn Leu Ile Asp Thr Glu His Trp Asp Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Phe Asn Ser Val Lys Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu Asn His Ile Arg Leu Lys Lys Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Ala Thr Val Val Asn Asn 
    50                  55                  60                  


His Glu Glu Phe Arg Ile Cys Phe Asp Glu Asn Asn Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Asn Tyr Thr Ile Phe His Glu Asp Asn Lys 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Glu Glu Ser Phe Ser Gly Phe 
            100                 105                 110         


Tyr Asn Lys Tyr Leu Glu Asp Ile Lys Thr Tyr Gly His Ile Met Ser 
        115                 120                 125             


Phe Glu Pro Lys Leu Asn Glu Ser Thr Asn Thr Phe Pro Ile Ser Cys 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Ile Gln Asp Asp 
145                 150                 155                 160 


Gly Thr Tyr Leu Thr Pro Ile Phe Thr Leu Gly Lys Tyr Phe Glu Gln 
                165                 170                 175     


Asn Asn Lys Thr Phe Ile Pro Ile Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Ile Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ala Ser Asp Phe Gln Ile Trp Leu Thr Tyr Lys 
    210                 215                 


<210>  65
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lachnospiraceae

<400>  65

Met Lys Phe Asn Leu Ile Asp Ile Glu Asp Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ala Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Gly Leu Leu Arg Glu Ile Lys Leu Lys Gly Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Thr Thr Val Val Asn Arg 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Gln Lys Gly Lys Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Val Phe His Lys Asp Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Glu Asn Phe Pro Arg Phe 
            100                 105                 110         


Tyr Tyr Asn Tyr Leu Glu Asp Ile Arg Asn Tyr Ser Asp Val Leu Asn 
        115                 120                 125             


Phe Met Pro Lys Thr Gly Glu Pro Ala Asn Thr Ile Asn Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Asn Phe Thr Gly Phe Asn Leu Asn Ile Tyr Asn Asp 
145                 150                 155                 160 


Ala Thr Tyr Leu Ile Pro Ile Phe Thr Leu Gly Lys Tyr Phe Gln Gln 
                165                 170                 175     


Asp Asn Lys Ile Leu Leu Pro Met Ser Val Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Phe Asn Glu Ala Gln Glu Leu 
        195                 200                 205             


Ala Ser Asn Tyr Glu Thr Trp Leu Gly Glu Lys 
    210                 215                 


<210>  66
<211>  219
<212>  PRT
<213>  Clostridium perfringens

<400>  66

Met Lys Phe Asn Leu Ile Asp Ile Glu Asp Trp Asn Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Leu Asn Ala Val Arg Cys Thr Tyr Ser Met Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Gly Leu Leu Arg Glu Ile Lys Leu Lys Gly Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Thr Thr Val Val Asn Arg 
    50                  55                  60                  


His Lys Glu Phe Arg Thr Cys Phe Asp Gln Lys Gly Lys Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Asn Pro Ser Tyr Thr Val Phe His Lys Asp Asn Glu 
                85                  90                  95      


Thr Phe Ser Ser Ile Trp Thr Glu Tyr Asp Glu Asn Phe Pro Arg Phe 
            100                 105                 110         


Tyr Tyr Asn Tyr Leu Glu Asp Ile Arg Asn Tyr Ser Asp Val Leu Asn 
        115                 120                 125             


Phe Met Pro Lys Thr Gly Glu Pro Ala Asn Thr Ile Asn Val Ser Ser 
    130                 135                 140                 


Ile Pro Trp Val Asn Phe Thr Gly Phe Asn Leu Asn Ile Tyr Asn Asp 
145                 150                 155                 160 


Ala Thr Tyr Leu Ile Pro Ile Phe Thr Leu Gly Lys Tyr Phe Gln Gln 
                165                 170                 175     


Asp Asn Lys Ile Leu Leu Pro Met Ser Val Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Ile Ser Arg Phe Phe Asn Glu Ala Gln Glu Leu 
        195                 200                 205             


Ala Ser Asn Tyr Glu Thr Trp Leu Gly Glu Lys 
    210                 215                 


<210>  67
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Clostrdium sp. BL8

<400>  67

Met Lys Phe Asn Leu Ile Asp Ile Asp Gln Trp Asp Arg Lys Pro Tyr 
1               5                   10                  15      


Phe Glu His Tyr Phe Asn Ser Val Lys Cys Thr Tyr Ser Ile Thr Ala 
            20                  25                  30          


Asn Ile Glu Ile Thr Asn Leu Leu Lys Asp Ile Lys Ile Thr Lys Leu 
        35                  40                  45              


Lys Leu Tyr Pro Thr Leu Ile Tyr Ile Ile Ala Thr Val Ile Asn Asn 
    50                  55                  60                  


His Glu Glu Phe Arg Thr Cys Phe Asp Glu Asn Asn Asn Leu Gly Tyr 
65                  70                  75                  80  


Trp Asp Ser Met Ser Pro Asn Tyr Thr Ile Phe His Glu Glu Thr Lys 
                85                  90                  95      


Thr Phe Ser Asn Ile Trp Thr Glu Tyr Asp Lys Ser Phe Ser Gly Phe 
            100                 105                 110         


Tyr Asn Lys Tyr Val Glu Asp Asn Lys Asn Tyr Gly Asn Ile Met Asn 
        115                 120                 125             


Phe Asp Pro Lys Leu Asn Glu Pro Ala Asn Thr Phe Pro Ile Ser Cys 
    130                 135                 140                 


Ile Pro Trp Val Ser Phe Thr Gly Phe Asn Leu Asn Ile Gln Asp His 
145                 150                 155                 160 


Gly Thr Tyr Leu Thr Pro Ile Phe Thr Leu Gly Lys Tyr Phe Glu Glu 
                165                 170                 175     


Asn Asn Lys Val Phe Ile Pro Met Ser Ile Gln Val His His Ala Val 
            180                 185                 190         


Cys Asp Gly Tyr His Thr Ser Arg Phe Ile Asn Glu Val Gln Glu Leu 
        195                 200                 205             


Ala Ser Asn Ser Gln Ser Trp Leu Lys His 
    210                 215             


<210>  68
<211>  660
<212>  DNA
<213>  Clostridium perfringens

<400>  68
atgaaattta atttgataga tattgaggat tggaatagaa agccatactt tgagcattat       60

ttaaatgcgg ttaggtgcac ttacagtatg actgcaaata tagagataac tggtttactg      120

cgtgaaatta aacttaaggg cctgaaactg taccctacgc ttatttatat catcacaact      180

gtggttaacc gtcacaagga gttccgcacc tgttttgatc aaaaaggtaa gttaggatac      240

tgggatagta tgaacccaag ttatactgtc tttcataagg ataacgaaac tttttcaagt      300

atttggacag agtatgacga gaacttccca cgtttttact ataattacct tgaggatatt      360

agaaactata gcgacgtttt gaatttcatg cctaagacag gtgaacctgc taatacaatt      420

aatgtgtcca gcattccttg ggtgaatttt accggattca acctgaatat atacaatgat      480

gcaacatatc taatccctat ttttactttg ggtaagtatt ttcagcagga taataaaatt      540

ttattaccta tgtctgtaca ggtgcatcat gcggtttgcg acggttatca tataagcaga      600

ttttttaatg aggcacagga attagcgtca aattatgaga catggttagg agaaaaataa      660


<210>  69
<211>  624
<212>  DNA
<213>  Clostridium difficile

<400>  69
atggtatttg aaaaaattga taaaaatagt tggaacagaa aagagtattt tgaccactac       60

tttgcaagtg taccttgtac atacagcatg accgttaaag tggatatcac acaaataaag      120

gaaaagggaa tgaaactata tcctgcaatg ctttattata ttgcaatgat tgtaaaccgc      180

cattcagagt ttaggacggc aatcaatcaa gatggtgaat tggggatata tgatgagatg      240

ataccaagct atacaatatt tcacaatgat actgaaacat tttccagcct ttggactgag      300

tgtaagtctg actttaaatc atttttagca gattatgaaa gtgatacgca acggtatgga      360

aacaatcata gaatggaagg aaagccaaat gctccggaaa acatttttaa tgtatctatg      420

ataccgtggt caaccttcga tggctttaat ctgaatttgc agaaaggata tgattatttg      480

attcctattt ttactatggg gaaatattat aaagaagata acaaaattat acttcctttg      540

gcaattcaag ttcatcacgc agtatgtgac ggatttcaca tttgccgttt tgtaaacgaa      600

ttgcaggaat tgataaatag ttaa                                             624


<210>  70
<211>  624
<212>  DNA
<213>  Clostridium perfringens

<400>  70
atggtatttg aaaaaattga taaaaatagt tggaacagaa aagagtattt tgaccactac       60

tttgcaagtg taccttgtac atacagcatg accgttaaag tggatatcac acaaataaag      120

gaaaagggaa tgaaactata tcctgcaatg ctttattata ttgcaatgat tgtaaaccgc      180

cattcagagt ttaggacggc aatcaatcaa gatggtgaat tggggatata tgatgagatg      240

ataccaagct atacaatatt tcacaatgat actgaaacat tttccagcct ttggactgag      300

tgtaagtctg actttaaatc atttttagca gattatgaaa gtgatacgca acggtatgga      360

aacaatcata gaatggaagg aaagccaaat gctccggaaa acatttttaa tgtatctatg      420

ataccgtggt caaccttcga tggctttaat ctgaatttgc agaaaggata tgattatttg      480

attcctattt ttactatggg gaaatattat aaagaagata acaaaattat acttcctttg      540

gcaattcaag ttcatcacgc agtatgtgac ggatttcaca tttgccgttt tgtaaacgaa      600

ttgcaggaat tgataaatag ttaa                                             624


<210>  71
<211>  3897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MAD7 optimise

<400>  71
ctcgagtccc tatcagtgat agattgaaac tctatcattg atagagtata atatctttgt       60

tcattagagc gataaacttg aatttgagag ggaacttaga tgaacaacgg cacaaataat      120

tttcagaact tcatagggat atcaagtttg cagaaaacgt taagaaatgc tttaataccc      180

acggaaacca cgcaacagtt catagttaag aacggaataa ttaaagaaga tgagttaaga      240

ggcgagaaca gacagatttt aaaagatata atggatgact actacagagg attcatatct      300

gagactttaa gttctattga tgacatagat tggactagct tattcgaaaa aatggaaatt      360

cagttaaaaa atggtgataa taaagatacc ttaattaagg aacagacaga gtatagaaaa      420

gcaatacata aaaaatttgc gaacgacgat agatttaaga acatgtttag cgccaaatta      480

attagtgaca tattacctga atttgttata cacaacaata attattcggc atcagagaaa      540

gaggaaaaaa cccaggtgat aaaattgttt tcgagatttg cgactagctt taaagattac      600

ttcaagaaca gagcaaattg cttttcagcg gacgatattt catcaagcag ctgccataga      660

atagttaacg acaatgcaga gatattcttt tcaaatgcgt tagtttacag aagaatagta      720

aaatcgttaa gcaatgacga tataaacaaa atttcgggcg atatgaaaga ttcattaaaa      780

gaaatgagtt tagaagaaat atattcttac gagaagtatg gggaatttat tacccaggaa      840

ggcattagct tctataatga tatatgtggg aaagtgaatt cttttatgaa cttatattgt      900

cagaaaaata aagaaaacaa aaatttatac aaacttcaga aacttcacaa acagattcta      960

tgcattgcgg acactagcta tgaggttccg tataaatttg aaagtgacga ggaagtgtac     1020

caatcagtta acggcttcct tgataacatt agcagcaaac atatagttga aagattaaga     1080

aaaataggcg ataactataa cggctacaac ttagataaaa tttatatagt gtccaaattt     1140

tacgagagcg ttagccaaaa aacctacaga gactgggaaa caattaatac cgccttagaa     1200

attcattaca ataatatatt gccgggtaac ggtaaaagta aagccgacaa agtaaaaaaa     1260

gcggttaaga atgatttaca gaaatccata accgaaataa atgaactagt gtcaaactat     1320

aagttatgca gtgacgacaa cataaaagcg gagacttata tacatgagat tagccatata     1380

ttgaataact ttgaagcaca ggaattgaaa tacaatccgg aaattcacct agttgaatcc     1440

gagttaaaag cgagtgagct taaaaacgtg ttagacgtga taatgaatgc gtttcattgg     1500

tgttcggttt ttatgactga ggaacttgtt gataaagaca acaattttta tgcggaatta     1560

gaggagattt acgatgaaat ttatccagta attagtttat acaacttagt tagaaactac     1620

gttacccaga aaccgtacag cacgaaaaag attaaattga actttggaat accgacgtta     1680

gcagacggtt ggtcaaagtc caaagagtat tctaataacg ctataatatt aatgagagac     1740

aatttatatt atttaggcat atttaatgcg aagaataaac cggacaagaa gattatagag     1800

ggtaatacgt cagaaaataa gggtgactac aaaaagatga tttataattt gttaccgggt     1860

cccaacaaaa tgataccgaa agttttcttg agcagcaaga cgggggtgga aacgtataaa     1920

ccgagcgcct atatactaga ggggtataaa cagaataaac atataaagtc ttcaaaagac     1980

tttgatataa ctttctgtca tgatttaata gactacttca aaaactgtat tgcaattcat     2040

cccgagtgga aaaacttcgg ttttgatttt agcgacacca gtacttatga agacatttcc     2100

gggttttata gagaggtaga gttacaaggt tacaagattg attggacata cattagcgaa     2160

aaagacattg atttattaca ggaaaaaggt caattatatt tattccagat atataacaaa     2220

gatttttcga aaaaatcaac cgggaatgac aaccttcaca ccatgtactt aaaaaatctt     2280

ttctcagaag aaaatcttaa ggatatagtt ttaaaactta acggcgaagc ggaaatattc     2340

ttcaggaaga gcagcataaa gaacccaata attcataaaa aaggctcgat tttagttaac     2400

agaacctacg aagcagaaga aaaagaccag tttggcaaca ttcaaattgt gagaaaaaat     2460

attccggaaa acatttatca ggagttatac aaatacttca acgataaaag cgacaaagag     2520

ttatctgatg aagcagccaa attaaagaat gtagtgggac accacgaggc agcgacgaat     2580

atagttaagg actatagata cacgtatgat aaatacttcc ttcatatgcc tattacgata     2640

aatttcaaag ccaataaaac gggttttatt aatgatagga tattacagta tatagctaaa     2700

gaaaaagact tacatgtgat aggcattgat agaggcgaga gaaacttaat atacgtgtcc     2760

gtgattgata cttgtggtaa tatagttgaa cagaaaagct ttaacattgt aaacggctac     2820

gactatcaga taaaattaaa acaacaggag ggcgctagac agattgcgag aaaagaatgg     2880

aaagaaattg gtaaaattaa agagataaaa gagggctact taagcttagt aatacacgag     2940

atatctaaaa tggtaataaa atacaatgca attatagcga tggaggattt gtcttatggt     3000

tttaaaaaag ggagatttaa ggttgaaaga caagtttacc agaaatttga aaccatgtta     3060

ataaataaat taaactattt agtatttaaa gatatttcga ttaccgagaa tggcggttta     3120

ttaaaaggtt atcagttaac atacattcct gataaactta aaaacgtggg tcatcagtgc     3180

ggctgcattt tttatgtgcc tgctgcatac acgagcaaaa ttgatccgac caccggcttt     3240

gtgaatatat ttaaatttaa agacttaaca gtggacgcaa aaagagaatt cattaaaaaa     3300

tttgactcaa ttagatatga cagtgaaaaa aatttattct gctttacatt tgactacaat     3360

aactttatta cgcaaaacac ggttatgagc aaatcatcgt ggagtgtgta tacatacggc     3420

gtgagaataa aaagaagatt tgtgaacggc agattctcaa acgaaagtga taccattgac     3480

ataaccaaag atatggagaa aacgttggaa atgacggaca ttaactggag agatggccac     3540

gatcttagac aagacattat agattatgaa attgttcagc acatattcga aattttcaga     3600

ttaacagtgc aaatgagaaa ctccttgtct gaattagagg acagagatta cgatagatta     3660

atttcacctg tattaaacga aaataacatt ttttatgaca gcgcgaaagc gggggatgca     3720

cttcctaagg atgccgatgc aaatggtgcg tattgtattg cattaaaagg gttatatgaa     3780

attaaacaaa ttaccgaaaa ttggaaagaa gatggtaaat tttcgagaga taaattaaaa     3840

ataagcaata aagattggtt cgactttata cagaataaga gatatttata agtcgac        3897


<210>  72
<211>  1263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAD7

<400>  72

Met Asn Asn Gly Thr Asn Asn Phe Gln Asn Phe Ile Gly Ile Ser Ser 
1               5                   10                  15      


Leu Gln Lys Thr Leu Arg Asn Ala Leu Ile Pro Thr Glu Thr Thr Gln 
            20                  25                  30          


Gln Phe Ile Val Lys Asn Gly Ile Ile Lys Glu Asp Glu Leu Arg Gly 
        35                  40                  45              


Glu Asn Arg Gln Ile Leu Lys Asp Ile Met Asp Asp Tyr Tyr Arg Gly 
    50                  55                  60                  


Phe Ile Ser Glu Thr Leu Ser Ser Ile Asp Asp Ile Asp Trp Thr Ser 
65                  70                  75                  80  


Leu Phe Glu Lys Met Glu Ile Gln Leu Lys Asn Gly Asp Asn Lys Asp 
                85                  90                  95      


Thr Leu Ile Lys Glu Gln Thr Glu Tyr Arg Lys Ala Ile His Lys Lys 
            100                 105                 110         


Phe Ala Asn Asp Asp Arg Phe Lys Asn Met Phe Ser Ala Lys Leu Ile 
        115                 120                 125             


Ser Asp Ile Leu Pro Glu Phe Val Ile His Asn Asn Asn Tyr Ser Ala 
    130                 135                 140                 


Ser Glu Lys Glu Glu Lys Thr Gln Val Ile Lys Leu Phe Ser Arg Phe 
145                 150                 155                 160 


Ala Thr Ser Phe Lys Asp Tyr Phe Lys Asn Arg Ala Asn Cys Phe Ser 
                165                 170                 175     


Ala Asp Asp Ile Ser Ser Ser Ser Cys His Arg Ile Val Asn Asp Asn 
            180                 185                 190         


Ala Glu Ile Phe Phe Ser Asn Ala Leu Val Tyr Arg Arg Ile Val Lys 
        195                 200                 205             


Ser Leu Ser Asn Asp Asp Ile Asn Lys Ile Ser Gly Asp Met Lys Asp 
    210                 215                 220                 


Ser Leu Lys Glu Met Ser Leu Glu Glu Ile Tyr Ser Tyr Glu Lys Tyr 
225                 230                 235                 240 


Gly Glu Phe Ile Thr Gln Glu Gly Ile Ser Phe Tyr Asn Asp Ile Cys 
                245                 250                 255     


Gly Lys Val Asn Ser Phe Met Asn Leu Tyr Cys Gln Lys Asn Lys Glu 
            260                 265                 270         


Asn Lys Asn Leu Tyr Lys Leu Gln Lys Leu His Lys Gln Ile Leu Cys 
        275                 280                 285             


Ile Ala Asp Thr Ser Tyr Glu Val Pro Tyr Lys Phe Glu Ser Asp Glu 
    290                 295                 300                 


Glu Val Tyr Gln Ser Val Asn Gly Phe Leu Asp Asn Ile Ser Ser Lys 
305                 310                 315                 320 


His Ile Val Glu Arg Leu Arg Lys Ile Gly Asp Asn Tyr Asn Gly Tyr 
                325                 330                 335     


Asn Leu Asp Lys Ile Tyr Ile Val Ser Lys Phe Tyr Glu Ser Val Ser 
            340                 345                 350         


Gln Lys Thr Tyr Arg Asp Trp Glu Thr Ile Asn Thr Ala Leu Glu Ile 
        355                 360                 365             


His Tyr Asn Asn Ile Leu Pro Gly Asn Gly Lys Ser Lys Ala Asp Lys 
    370                 375                 380                 


Val Lys Lys Ala Val Lys Asn Asp Leu Gln Lys Ser Ile Thr Glu Ile 
385                 390                 395                 400 


Asn Glu Leu Val Ser Asn Tyr Lys Leu Cys Ser Asp Asp Asn Ile Lys 
                405                 410                 415     


Ala Glu Thr Tyr Ile His Glu Ile Ser His Ile Leu Asn Asn Phe Glu 
            420                 425                 430         


Ala Gln Glu Leu Lys Tyr Asn Pro Glu Ile His Leu Val Glu Ser Glu 
        435                 440                 445             


Leu Lys Ala Ser Glu Leu Lys Asn Val Leu Asp Val Ile Met Asn Ala 
    450                 455                 460                 


Phe His Trp Cys Ser Val Phe Met Thr Glu Glu Leu Val Asp Lys Asp 
465                 470                 475                 480 


Asn Asn Phe Tyr Ala Glu Leu Glu Glu Ile Tyr Asp Glu Ile Tyr Pro 
                485                 490                 495     


Val Ile Ser Leu Tyr Asn Leu Val Arg Asn Tyr Val Thr Gln Lys Pro 
            500                 505                 510         


Tyr Ser Thr Lys Lys Ile Lys Leu Asn Phe Gly Ile Pro Thr Leu Ala 
        515                 520                 525             


Asp Gly Trp Ser Lys Ser Lys Glu Tyr Ser Asn Asn Ala Ile Ile Leu 
    530                 535                 540                 


Met Arg Asp Asn Leu Tyr Tyr Leu Gly Ile Phe Asn Ala Lys Asn Lys 
545                 550                 555                 560 


Pro Asp Lys Lys Ile Ile Glu Gly Asn Thr Ser Glu Asn Lys Gly Asp 
                565                 570                 575     


Tyr Lys Lys Met Ile Tyr Asn Leu Leu Pro Gly Pro Asn Lys Met Ile 
            580                 585                 590         


Pro Lys Val Phe Leu Ser Ser Lys Thr Gly Val Glu Thr Tyr Lys Pro 
        595                 600                 605             


Ser Ala Tyr Ile Leu Glu Gly Tyr Lys Gln Asn Lys His Ile Lys Ser 
    610                 615                 620                 


Ser Lys Asp Phe Asp Ile Thr Phe Cys His Asp Leu Ile Asp Tyr Phe 
625                 630                 635                 640 


Lys Asn Cys Ile Ala Ile His Pro Glu Trp Lys Asn Phe Gly Phe Asp 
                645                 650                 655     


Phe Ser Asp Thr Ser Thr Tyr Glu Asp Ile Ser Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Leu Gln Gly Tyr Lys Ile Asp Trp Thr Tyr Ile Ser Glu Lys 
        675                 680                 685             


Asp Ile Asp Leu Leu Gln Glu Lys Gly Gln Leu Tyr Leu Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Lys Lys Ser Thr Gly Asn Asp Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Leu Lys Asn Leu Phe Ser Glu Glu Asn Leu Lys Asp Ile 
                725                 730                 735     


Val Leu Lys Leu Asn Gly Glu Ala Glu Ile Phe Phe Arg Lys Ser Ser 
            740                 745                 750         


Ile Lys Asn Pro Ile Ile His Lys Lys Gly Ser Ile Leu Val Asn Arg 
        755                 760                 765             


Thr Tyr Glu Ala Glu Glu Lys Asp Gln Phe Gly Asn Ile Gln Ile Val 
    770                 775                 780                 


Arg Lys Asn Ile Pro Glu Asn Ile Tyr Gln Glu Leu Tyr Lys Tyr Phe 
785                 790                 795                 800 


Asn Asp Lys Ser Asp Lys Glu Leu Ser Asp Glu Ala Ala Lys Leu Lys 
                805                 810                 815     


Asn Val Val Gly His His Glu Ala Ala Thr Asn Ile Val Lys Asp Tyr 
            820                 825                 830         


Arg Tyr Thr Tyr Asp Lys Tyr Phe Leu His Met Pro Ile Thr Ile Asn 
        835                 840                 845             


Phe Lys Ala Asn Lys Thr Gly Phe Ile Asn Asp Arg Ile Leu Gln Tyr 
    850                 855                 860                 


Ile Ala Lys Glu Lys Asp Leu His Val Ile Gly Ile Asp Arg Gly Glu 
865                 870                 875                 880 


Arg Asn Leu Ile Tyr Val Ser Val Ile Asp Thr Cys Gly Asn Ile Val 
                885                 890                 895     


Glu Gln Lys Ser Phe Asn Ile Val Asn Gly Tyr Asp Tyr Gln Ile Lys 
            900                 905                 910         


Leu Lys Gln Gln Glu Gly Ala Arg Gln Ile Ala Arg Lys Glu Trp Lys 
        915                 920                 925             


Glu Ile Gly Lys Ile Lys Glu Ile Lys Glu Gly Tyr Leu Ser Leu Val 
    930                 935                 940                 


Ile His Glu Ile Ser Lys Met Val Ile Lys Tyr Asn Ala Ile Ile Ala 
945                 950                 955                 960 


Met Glu Asp Leu Ser Tyr Gly Phe Lys Lys Gly Arg Phe Lys Val Glu 
                965                 970                 975     


Arg Gln Val Tyr Gln Lys Phe Glu Thr Met Leu Ile Asn Lys Leu Asn 
            980                 985                 990         


Tyr Leu Val Phe Lys Asp Ile Ser  Ile Thr Glu Asn Gly  Gly Leu Leu 
        995                 1000                 1005             


Lys Gly  Tyr Gln Leu Thr Tyr  Ile Pro Asp Lys Leu  Lys Asn Val 
    1010                 1015                 1020             


Gly His  Gln Cys Gly Cys Ile  Phe Tyr Val Pro Ala  Ala Tyr Thr 
    1025                 1030                 1035             


Ser Lys  Ile Asp Pro Thr Thr  Gly Phe Val Asn Ile  Phe Lys Phe 
    1040                 1045                 1050             


Lys Asp  Leu Thr Val Asp Ala  Lys Arg Glu Phe Ile  Lys Lys Phe 
    1055                 1060                 1065             


Asp Ser  Ile Arg Tyr Asp Ser  Glu Lys Asn Leu Phe  Cys Phe Thr 
    1070                 1075                 1080             


Phe Asp  Tyr Asn Asn Phe Ile  Thr Gln Asn Thr Val  Met Ser Lys 
    1085                 1090                 1095             


Ser Ser  Trp Ser Val Tyr Thr  Tyr Gly Val Arg Ile  Lys Arg Arg 
    1100                 1105                 1110             


Phe Val  Asn Gly Arg Phe Ser  Asn Glu Ser Asp Thr  Ile Asp Ile 
    1115                 1120                 1125             


Thr Lys  Asp Met Glu Lys Thr  Leu Glu Met Thr Asp  Ile Asn Trp 
    1130                 1135                 1140             


Arg Asp  Gly His Asp Leu Arg  Gln Asp Ile Ile Asp  Tyr Glu Ile 
    1145                 1150                 1155             


Val Gln  His Ile Phe Glu Ile  Phe Arg Leu Thr Val  Gln Met Arg 
    1160                 1165                 1170             


Asn Ser  Leu Ser Glu Leu Glu  Asp Arg Asp Tyr Asp  Arg Leu Ile 
    1175                 1180                 1185             


Ser Pro  Val Leu Asn Glu Asn  Asn Ile Phe Tyr Asp  Ser Ala Lys 
    1190                 1195                 1200             


Ala Gly  Asp Ala Leu Pro Lys  Asp Ala Asp Ala Asn  Gly Ala Tyr 
    1205                 1210                 1215             


Cys Ile  Ala Leu Lys Gly Leu  Tyr Glu Ile Lys Gln  Ile Thr Glu 
    1220                 1225                 1230             


Asn Trp  Lys Glu Asp Gly Lys  Phe Ser Arg Asp Lys  Leu Lys Ile 
    1235                 1240                 1245             


Ser Asn  Lys Asp Trp Phe Asp  Phe Ile Gln Asn Lys  Arg Tyr Leu 
    1250                 1255                 1260             


<210>  73
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoteur CatB

<400>  73
taaaaaatgt tacgcacttt tcttatattg ttcaacaata acataattta ttaacaaaag       60

gaaagtatag ttaaaaaaat gttggagcaa atgcggatgg aaaaataaaa attaatatta      120

gtagtaattc cgatgttaaa ataacaagag ataagaaaaa gtaaaatatt agagtaattc      180

gtagtattct taagttatga atcaataaaa aatggtctct gaaaattgaa tagttcggta      240

ttacagaatg tgctataata aactaaagcg taaatatcat tgtaaaaagg agattgaaat      300

ggctaggtca cggaaaaaag ccttctaaaa tagaattacg aaaattttta ggaggcccga      360

att                                                                    363


<210>  74
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoteur CATQ

<400>  74
ctgcgtacac atccagacat cgctttagag tatggtgaat taaagatgga gcgggcttat       60

cgattctcag aggatattga aggctactgc actggtaagg atgcatttgt aaagcaacta      120

gaaaaggatg ctttgcgatg gtggcaaact gtctgttagg aggttattct caaaggattg      180

caagaagcag ttgaggataa tccgtataac taactattac acattcttaa cattgctggt      240

ttgtatcggt agaataacac gaattaacaa aggatatatt ttgtagtagc aagtgtattt      300

gttttatatt ctatgaacct at                                               322


<210>  75
<211>  1368
<212>  PRT
<213>  Streptococcus pyogenes

<400>  75

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  76
<211>  4107
<212>  DNA
<213>  Streptococcus pyogenes

<400>  76
atggataaga aatactcaat aggcttagat atcggcacaa atagcgtcgg atgggcggtg       60

atcactgatg aatataaggt tccgtctaaa aagttcaagg ttctgggaaa tacagaccgc      120

cacagtatca aaaaaaatct tataggggct cttttatttg acagtggaga gacagcggaa      180

gcgactcgtc tcaaacggac agctcgtaga aggtatacac gtcggaagaa tcgtatttgt      240

tatctacagg agattttttc aaatgagatg gcgaaagtag atgatagttt ctttcatcga      300

cttgaagagt cttttttggt ggaagaagac aagaagcatg aacgtcatcc tatttttgga      360

aatatagtag atgaagttgc ttatcatgag aaatatccaa ctatctatca tctgcgaaaa      420

aaattggtag attctactga taaagcggat ttgcgcttaa tctatttggc cttagcgcat      480

atgattaagt ttcgtggtca ttttttgatt gagggagatt taaatcctga taatagtgat      540

gtggacaaac tatttatcca gttggtacaa acctacaatc aattatttga agaaaaccct      600

attaacgcaa gtggagtaga tgctaaagcg attctttctg cacgattgag taaatcaaga      660

cgattagaaa atctcattgc tcagctcccc ggtgagaaga aaaatggctt atttgggaat      720

ctcattgctt tgtcattggg tttgacccct aattttaaat caaattttga tttggcagaa      780

gatgctaaat tacagctttc aaaagatact tacgatgatg atttagataa tttattggcg      840

caaattggag atcaatatgc tgatttgttt ttggcagcta agaatttatc agatgctatt      900

ttactttcag atatcctaag agtaaatact gaaataacta aggctcccct atcagcttca      960

atgattaaac gctacgatga acatcatcaa gacttgactc ttttaaaagc tttagttcga     1020

caacaacttc cagaaaagta taaagaaatc ttttttgatc aatcaaaaaa cggatatgca     1080

ggttatattg atgggggagc tagccaagaa gaattttata aatttatcaa accaatttta     1140

gaaaaaatgg atggtactga ggaattattg gtgaaactaa atcgtgaaga tttgctgcgc     1200

aagcaacgga cctttgacaa cggctctatt ccccatcaaa ttcacttggg tgagctgcat     1260

gctattttga gaagacaaga agacttttat ccatttttaa aagacaatcg tgagaagatt     1320

gaaaaaatct tgacttttcg aattccttat tatgttggtc cattggcgcg tggcaatagt     1380

cgttttgcat ggatgactcg gaagtctgaa gaaacaatta ccccatggaa ttttgaagaa     1440

gttgtcgata aaggtgcttc agctcaatca tttattgaac gcatgacaaa ctttgataaa     1500

aatcttccaa atgaaaaagt actaccaaaa catagtttgc tttatgagta ttttacggtt     1560

tataacgaat tgacaaaggt caaatatgtt actgaaggaa tgcgaaaacc agcatttctt     1620

tcaggtgaac agaagaaagc cattgttgat ttactcttca aaacaaatcg aaaagtaacc     1680

gttaagcaat taaaagaaga ttatttcaaa aaaatagaat gttttgatag tgttgaaatt     1740

tcaggagttg aagatagatt taatgcttca ttaggtacct accatgattt gctaaaaatt     1800

attaaagata aagatttttt ggataatgaa gaaaatgaag atatcttaga ggatattgtt     1860

ttaacattga ccttatttga agatagggag atgattgagg aaagacttaa aacatatgct     1920

cacctctttg atgataaggt gatgaaacag cttaaacgtc gccgttatac tggttgggga     1980

cgtttgtctc gaaaattgat taatggtatt agggataagc aatctggcaa aacaatatta     2040

gattttttga aatcagatgg ttttgccaat cgcaatttta tgcagctgat ccatgatgat     2100

agtttgacat ttaaagaaga cattcaaaaa gcacaagtgt ctggacaagg cgatagttta     2160

catgaacata ttgcaaattt agctggtagc cctgctatta aaaaaggtat tttacagact     2220

gtaaaagttg ttgatgaatt ggtcaaagta atggggcggc ataagccaga aaatatcgtt     2280

attgaaatgg cacgtgaaaa tcagacaact caaaagggcc agaaaaattc gcgagagcgt     2340

atgaaacgaa tcgaagaagg tatcaaagaa ttaggaagtc agattcttaa agagcatcct     2400

gttgaaaata ctcaattgca aaatgaaaag ctctatctct attatctcca aaatggaaga     2460

gacatgtatg tggaccaaga attagatatt aatcgtttaa gtgattatga tgtcgatcac     2520

attgttccac aaagtttcct taaagacgat tcaatagaca ataaggtctt aacgcgttct     2580

gataaaaatc gtggtaaatc ggataacgtt ccaagtgaag aagtagtcaa aaagatgaaa     2640

aactattgga gacaacttct aaacgccaag ttaatcactc aacgtaagtt tgataattta     2700

acgaaagctg aacgtggagg tttgagtgaa cttgataaag ctggttttat caaacgccaa     2760

ttggttgaaa ctcgccaaat cactaagcat gtggcacaaa ttttggatag tcgcatgaat     2820

actaaatacg atgaaaatga taaacttatt cgagaggtta aagtgattac cttaaaatct     2880

aaattagttt ctgacttccg aaaagatttc caattctata aagtacgtga gattaacaat     2940

taccatcatg cccatgatgc gtatctaaat gccgtcgttg gaactgcttt gattaagaaa     3000

tatccaaaac ttgaatcgga gtttgtctat ggtgattata aagtttatga tgttcgtaaa     3060

atgattgcta agtctgagca agaaataggc aaagcaaccg caaaatattt cttttactct     3120

aatatcatga acttcttcaa aacagaaatt acacttgcaa atggagagat tcgcaaacgc     3180

cctctaatcg aaactaatgg ggaaactgga gaaattgtct gggataaagg gcgagatttt     3240

gccacagtgc gcaaagtatt gtccatgccc caagtcaata ttgtcaagaa aacagaagta     3300

cagacaggcg gattctccaa ggagtcaatt ttaccaaaaa gaaattcgga caagcttatt     3360

gctcgtaaaa aagactggga tccaaaaaaa tatggtggtt ttgatagtcc aacggtagct     3420

tattcagtcc tagtggttgc taaggtggaa aaagggaaat cgaagaagtt aaaatccgtt     3480

aaagagttac tagggatcac aattatggaa agaagttcct ttgaaaaaaa tccgattgac     3540

tttttagaag ctaaaggata taaggaagtt aaaaaagact taatcattaa actacctaaa     3600

tatagtcttt ttgagttaga aaacggtcgt aaacggatgc tggctagtgc cggagaatta     3660

caaaaaggaa atgagctggc tctgccaagc aaatatgtga attttttata tttagctagt     3720

cattatgaaa agttgaaggg tagtccagaa gataacgaac aaaaacaatt gtttgtggag     3780

cagcataagc attatttaga tgagattatt gagcaaatca gtgaattttc taagcgtgtt     3840

attttagcag atgccaattt agataaagtt cttagtgcat ataacaaaca tagagacaaa     3900

ccaatacgtg aacaagcaga aaatattatt catttattta cgttgacgaa tcttggagct     3960

cccgctgctt ttaaatattt tgatacaaca attgatcgta aacgatatac gtctacaaaa     4020

gaagttttag atgccactct tatccatcaa tccatcactg gtctttatga aacacgcatt     4080

gatttgagtc agctaggagg tgactga                                         4107


<210>  77
<211>  1170
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bdhA

<400>  77
atgctaagtt ttgattattc aataccaact aaagtttttt ttggaaaagg aaaaatagac       60

gtaattggag aagaaattaa gaaatatggc tcaagagtgc ttatagttta tggcggagga      120

agtataaaaa ggaacggtat atatgataga gcaacagcta tattaaaaga aaacaatata      180

gctttctatg aactttcagg agtagagcca aatcctagga taacaacagt aaaaaaaggc      240

atagaaatat gtagagaaaa taatgtggat ttagtattag caataggggg aggaagtgca      300

atagactgtt ctaaggtaat tgcagctgga gtttattatg atggcgatac atgggacatg      360

gttaaagatc catctaaaat aactaaagtt cttccaattg caagtatact tactctttca      420

gcaacagggt ctgaaatgga tcaaattgca gtaatttcaa atatggagac taatgaaaag      480

cttggagtag gacatgatga tatgagacct aaattttcag tgttagatcc tacatatact      540

tttacagtac ctaaaaatca aacagcagcg ggaacagctg acattatgag tcacaccttt      600

gaatcttact ttagtggtgt tgaaggtgct tatgtgcagg acggtatagc agaagcaatc      660

ttaagaacat gtataaagta tggaaaaata gcaatggaga agactgatga ttacgaggct      720

agagctaatt tgatgtgggc ttcaagttta gctataaatg gtctattatc acttggtaag      780

gatagaaaat ggagttgtca tcctatggaa cacgagttaa gtgcatatta tgatataaca      840

catggtgtag gacttgcaat tttaacacct aattggatgg aatatattct aaatgacgat      900

acacttcata aatttgtttc ttatggaata aatgtttggg gaatagacaa gaacaaagat      960

aactatgaaa tagcacgaga ggctattaaa aatacgagag aatactttaa ttcattgggt     1020

attccttcaa agcttagaga agttggaata ggaaaagata aactagaact aatggcaaag     1080

caagctgtta gaaattctgg aggaacaata ggaagtttaa gaccaataaa tgcagaggat     1140

gttcttgaga tatttaaaaa atcttattaa                                      1170


<210>  78
<211>  1173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  bdhB

<400>  78
gtggttgatt tcgaatattc aataccaact agaatttttt tcggtaaaga taagataaat       60

gtacttggaa gagagcttaa aaaatatggt tctaaagtgc ttatagttta tggtggagga      120

agtataaaga gaaatggaat atatgataaa gctgtaagta tacttgaaaa aaacagtatt      180

aaattttatg aacttgcagg agtagagcca aatccaagag taactacagt tgaaaaagga      240

gttaaaatat gtagagaaaa tggagttgaa gtagtactag ctataggtgg aggaagtgca      300

atagattgcg caaaggttat agcagcagca tgtgaatatg atggaaatcc atgggatatt      360

gtgttagatg gctcaaaaat aaaaagggtg cttcctatag ctagtatatt aaccattgct      420

gcaacaggat cagaaatgga tacgtgggca gtaataaata atatggatac aaacgaaaaa      480

ctaattgcgg cacatccaga tatggctcct aagttttcta tattagatcc aacgtatacg      540

tataccgtac ctaccaatca aacagcagca ggaacagctg atattatgag tcatatattt      600

gaggtgtatt ttagtaatac aaaaacagca tatttgcagg atagaatggc agaagcgtta      660

ttaagaactt gtattaaata tggaggaata gctcttgaga agccggatga ttatgaggca      720

agagccaatc taatgtgggc ttcaagtctt gcgataaatg gacttttaac atatggtaaa      780

gacactaatt ggagtgtaca cttaatggaa catgaattaa gtgcttatta cgacataaca      840

cacggcgtag ggcttgcaat tttaacacct aattggatgg agtatatttt aaataatgat      900

acagtgtaca agtttgttga atatggtgta aatgtttggg gaatagacaa agaaaaaaat      960

cactatgaca tagcacatca agcaatacaa aaaacaagag attactttgt aaatgtacta     1020

ggtttaccat ctagactgag agatgttgga attgaagaag aaaaattgga cataatggca     1080

aaggaatcag taaagcttac aggaggaacc ataggaaacc taagaccagt aaacgcctcc     1140

gaagtcctac aaatattcaa aaaatctgtg taa                                  1173


<210>  79
<211>  6560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-deltabdhB

<400>  79
gatccccggg taccgagctc gaattcgtaa tcatggtcat agctgtttcc tgtgtgaaat       60

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg      120

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag      180

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt      240

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      300

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      360

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      420

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      480

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      540

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      600

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      660

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      720

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      780

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      840

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      900

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      960

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     1020

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     1080

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     1140

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1200

caaagctagc ttaatactag tatatactta atgtgataag tgtctgacag ctgaccggtc     1260

taaagaggtc cctagcgcct acggggaatt tgtatcgata aggggtacaa attcccacta     1320

agcgctcggc cggggatcga tccccgggta cgtacccggc agtttttctt tttcggcaag     1380

tgttcaagaa gttattaagt cgggagtgca gtcgaagtgg gcaagttgaa aaattcacaa     1440

aaatgtggta taatatcttt gttcattaga gcgataaact tgaatttgag agggaactta     1500

gatggtattt gaaaaaattg ataaaaatag ttggaacaga aaagagtatt ttgaccacta     1560

ctttgcaagt gtaccttgta cctacagcat gaccgttaaa gtggatatca cacaaataaa     1620

ggaaaaggga atgaaactat atcctgcaat gctttattat attgcaatga ttgtaaaccg     1680

ccattcagag tttaggacgg caatcaatca agatggtgaa ttggggatat atgatgagat     1740

gataccaagc tatacaatat ttcacaatga tactgaaaca ttttccagcc tttggactga     1800

gtgtaagtct gactttaaat catttttagc agattatgaa agtgatacgc aacggtatgg     1860

aaacaatcat agaatggaag gaaagccaaa tgctccggaa aacattttta atgtatctat     1920

gataccgtgg tcaaccttcg atggctttaa tctgaatttg cagaaaggat atgattattt     1980

gattcctatt tttactatgg ggaaatatta taaagaagat aacaaaatta tacttccttt     2040

ggcaattcaa gttcatcacg cagtatgtga cggatttcac atttgccgtt ttgtaaacga     2100

attgcaggaa ttgataaata gttaacttca ggtttgtctg taactaaaaa ctagtattta     2160

acctaggatc aaaaaaattt ccaataatcc cactctaagc cacaaacacg ccctataaaa     2220

tcccgcttta atcccacttt gagacacatg taatattact ttacgcccta gtatagtgat     2280

aattttttac attcaatgcc acgcaaaaaa ataaaggggc actataataa aagttccttc     2340

ggaactaact aaagtaaaaa attatcttta caacctcccc aaaaaaaaga acaggtacaa     2400

agtaccctat aatacaagcg taaaaaaaat gagggtaaaa ataaaaaaat aaaaaaataa     2460

aaaaataaaa aaataaaaaa ataaaaaaat aaaaaaatat aaaaataaaa aaatataaaa     2520

ataaaaaaat ataaaaataa aaaaataaaa aaatataaaa ataaaaaaat aaaaaaatat     2580

aaaaatattt tttatttaaa gtttgaaaaa aattttttta tattatataa tctttgaaga     2640

aaagaatata aaaaatgagc ctttataaaa gcccattttt tttcatatac gtaatatgac     2700

gttctaatgt ttttattggt acttctaaca ttagagtaat ttctttattt ttaaagcctt     2760

tttctttaag ggcttttatt ttttttctta atacatttaa ttcctctttt tttgttgctt     2820

ttcctttagc ttttaattgc tcttgataat tttttttacc tctaatattt tctcttctct     2880

tatattcctt tttagaaatt attattgtca tatatttttg ttcttcttct gtaatttcta     2940

ataactctat aagagtttca ttcttatact tatattgctt atttttatct aaataacatc     3000

tttcagcact tctagttgct cttataactt ctctttcact taaatgttgt ctaaacatac     3060

tattaagttc taaaacatca tttaatgcct tctcaatgtc ttctgtaaag ctacaaagat     3120

aatatctata taaaaataat ataagctctc tgtgtccttt taaatcatat tctcttagtt     3180

cacaaagttt tattatgtct tgtattcttc cataatataa acttctttct ctataaatat     3240

aatttatttt gcttggtcta ccctttttcc tttcatatgg ttttaattca ggtaaaaatc     3300

cattttgtat ttctcttaag tcataaatat attcgtactc atctaatata ttgactactg     3360

tttttgattt agagtttata cttcctggaa ctcttaatat tctcgttgca tctaaggctt     3420

gtctatctgc tccaaagtat tttaattgat tatataaata ttcttgaacc gctttccata     3480

atggtaatgc tttactaggt actgcattta ttatccatat taaatacatt cctcttccac     3540

tatctattac atagtttggt ataggaatac tttgattaaa ataattcttt tctaagtcca     3600

ttaatacctg gtctttagtt ttgccagttt tataataatc caagtctata aacagtgtat     3660

ttaactcttt tatattttct aatcgcctac acggcttata aaaggtattt agagttatat     3720

agatattttc atcactcata tctaaatctt ttaattcagc gtatttatag tgccattggc     3780

tatatccttt tttatctata acgctcctgg ttatccaccc tttacttcta ctatgaatat     3840

tatctatata gttcttttta ttcagcttta atgcgtttct cacttattca cctccccttc     3900

tgtaaaacta agaaaattat atcatatttt caataattat taactattct taaactctta     3960

ataaaaaata gagtaagtcc ccaattgaaa cttaatctat tttttatgtt ttaatttatt     4020

atttttatta aaatatttta aactaaatta aatgattctt tttaattttt tactatttca     4080

ttccataata tattactata attatttaca aataatattt cttcatttgt aatatttaga     4140

tgatttacta attttagttt ttatatatta aataattaat gtataattta tataaaaaat     4200

caaaggagct tataaattat gattatttcc aaagatacta aagatttaat ttttttcaat     4260

tttaacaata ctttttgtaa tattatgttt aaatttaatt gtattttttt catataataa     4320

agccgttgaa gtaaaccaat ccattttcct tatgatgtta ttattaaatt taagttttat     4380

aataatatct ttattatatt tattgttttt aaaaaaacta gtgaaatttc tagtgaaatt     4440

tccggcttta ttaaacttat ttttaggaat tttattttca ttttcatctt tacaggattt     4500

gattatatct ttaaatatgt tttatcaaat attatctttt tctaaattta tatatatttt     4560

tattatattt attattatat atattttatt tttaagtttc tttctaacag ctattaaaaa     4620

gaaacttaaa aataaaaaca cgtactctaa accaataaat aaaactattt ttattattgc     4680

tgccttgatt ggaatagttt ttagtaaaat taatttcaat attccacaat attatattat     4740

aagctagcac gcctcgagac tctatcattg atagagtttg aaactctatc attgatagag     4800

tataatatct ttgttcatgc ttattacgac ataacacagt tttagagcta gaaatagcaa     4860

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt     4920

tgaagcttct cgagatctcc atggacgcgt gacgtcgact cttaagaaca tgtataaagt     4980

atggaaaaat agcaatggag aagactgatg attacgaggc tagagctaat ttgatgtggg     5040

cttcaagttt agctataaat ggtctattat cacttggtaa ggatagaaaa tggagttgtc     5100

atcctatgga acacgagtta agtgcatatt atgatataac acatggtgta ggacttgcaa     5160

ttttaacacc taattggatg gaatatattc taaatgacga tacacttcat aaatttgttt     5220

cttatggaat aaatgtttgg ggaatagaca agaacaaaga taactatgaa atagcacgag     5280

aggctattaa aaatacgaga gaatacttta attcattggg tattccttca aagcttagag     5340

aagttggaat aggaaaagat aaactagaac taatggcaaa gcaagctgtt agaaattctg     5400

gaggaacaat aggaagttta agaccaataa atgcagagga tgttcttgag atatttaaaa     5460

aatcttatta atagaaactg tagaggtatt tttataattt aaaagatgtt aaagagtgag     5520

gagtaatttt gttctaacgc ctcactcttt tcattttatg attaaatgta tgctgattta     5580

cgctaactta aatcctaaat aataacctaa tgttaatatt ttgtaacaaa tggataaaag     5640

cgtaaaaata ttattgtaat aattttaagt aggtttaaaa tatatataat gtagaagcat     5700

tcctacatta tattatttaa ataataatct aaacaggagg ggttaaagtg gttgatttca     5760

aatctgtgta aacctaccgg ggtttgggcg tagccattat attcatgaac tccaagaaag     5820

cagtatgcta gcaaagaaat aaaactcaaa gcagagagaa aatttagaca ttcaactata     5880

aataaaaaat accccccaaa gcattaatat cttggggagt attttttatt ttgaagtatt     5940

ctgttcagct aaatattctt ctaaggtaat acctctgttc ataatttctt gtgaggcagg     6000

aagaccgata tatcttacat gccatggctc aaaattatac tttgttatgt tttctttatc     6060

cttaggatat cttattatga aaccatattt accacaattt tgttgaagcc atttataaga     6120

atttgtattc ataaatccat catctaaaga agagtattcg gttgatagta agtccattgc     6180

caatccagtt tgatgctcac ttgtaccagg ttcagctaca tatttatcag cttcggcttt     6240

tccgtctcgt gctacttttt cattatataa tttttgctga tacgaataag gtctataacc     6300

tgaaacagct agaagtgtaa gaccatcctt tgatgctgca ttaaacatat tttcaagtcc     6360

tgttgcagct tcgctctcca tttgatttac attaggatca gaactactaa taaatttaac     6420

gttaggagtt ctcaaatttt gaggtatata gtttcctgat aatttacttt gcttgtttac     6480

aagtaggatg ttctgtttct ttacctcggg tttcttggct tgttttttag gtgtagaaac     6540

tttctttttg ggttcgtttg                                                 6560


<210>  80
<211>  6560
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA_deltabdhA_deltabdhB

<400>  80
gatccccggg taccgagctc gaattcgtaa tcatggtcat agctgtttcc tgtgtgaaat       60

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg      120

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag      180

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt      240

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg      300

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg      360

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag      420

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga      480

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct      540

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc      600

tttctccctt cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg      660

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc      720

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca      780

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag      840

ttcttgaagt ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct      900

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc      960

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     1020

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     1080

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     1140

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     1200

caaagctagc ttaatactag tatatactta atgtgataag tgtctgacag ctgaccggtc     1260

taaagaggtc cctagcgcct acggggaatt tgtatcgata aggggtacaa attcccacta     1320

agcgctcggc cggggatcga tccccgggta cgtacccggc agtttttctt tttcggcaag     1380

tgttcaagaa gttattaagt cgggagtgca gtcgaagtgg gcaagttgaa aaattcacaa     1440

aaatgtggta taatatcttt gttcattaga gcgataaact tgaatttgag agggaactta     1500

gatggtattt gaaaaaattg ataaaaatag ttggaacaga aaagagtatt ttgaccacta     1560

ctttgcaagt gtaccttgta cctacagcat gaccgttaaa gtggatatca cacaaataaa     1620

ggaaaaggga atgaaactat atcctgcaat gctttattat attgcaatga ttgtaaaccg     1680

ccattcagag tttaggacgg caatcaatca agatggtgaa ttggggatat atgatgagat     1740

gataccaagc tatacaatat ttcacaatga tactgaaaca ttttccagcc tttggactga     1800

gtgtaagtct gactttaaat catttttagc agattatgaa agtgatacgc aacggtatgg     1860

aaacaatcat agaatggaag gaaagccaaa tgctccggaa aacattttta atgtatctat     1920

gataccgtgg tcaaccttcg atggctttaa tctgaatttg cagaaaggat atgattattt     1980

gattcctatt tttactatgg ggaaatatta taaagaagat aacaaaatta tacttccttt     2040

ggcaattcaa gttcatcacg cagtatgtga cggatttcac atttgccgtt ttgtaaacga     2100

attgcaggaa ttgataaata gttaacttca ggtttgtctg taactaaaaa ctagtattta     2160

acctaggatc aaaaaaattt ccaataatcc cactctaagc cacaaacacg ccctataaaa     2220

tcccgcttta atcccacttt gagacacatg taatattact ttacgcccta gtatagtgat     2280

aattttttac attcaatgcc acgcaaaaaa ataaaggggc actataataa aagttccttc     2340

ggaactaact aaagtaaaaa attatcttta caacctcccc aaaaaaaaga acaggtacaa     2400

agtaccctat aatacaagcg taaaaaaaat gagggtaaaa ataaaaaaat aaaaaaataa     2460

aaaaataaaa aaataaaaaa ataaaaaaat aaaaaaatat aaaaataaaa aaatataaaa     2520

ataaaaaaat ataaaaataa aaaaataaaa aaatataaaa ataaaaaaat aaaaaaatat     2580

aaaaatattt tttatttaaa gtttgaaaaa aattttttta tattatataa tctttgaaga     2640

aaagaatata aaaaatgagc ctttataaaa gcccattttt tttcatatac gtaatatgac     2700

gttctaatgt ttttattggt acttctaaca ttagagtaat ttctttattt ttaaagcctt     2760

tttctttaag ggcttttatt ttttttctta atacatttaa ttcctctttt tttgttgctt     2820

ttcctttagc ttttaattgc tcttgataat tttttttacc tctaatattt tctcttctct     2880

tatattcctt tttagaaatt attattgtca tatatttttg ttcttcttct gtaatttcta     2940

ataactctat aagagtttca ttcttatact tatattgctt atttttatct aaataacatc     3000

tttcagcact tctagttgct cttataactt ctctttcact taaatgttgt ctaaacatac     3060

tattaagttc taaaacatca tttaatgcct tctcaatgtc ttctgtaaag ctacaaagat     3120

aatatctata taaaaataat ataagctctc tgtgtccttt taaatcatat tctcttagtt     3180

cacaaagttt tattatgtct tgtattcttc cataatataa acttctttct ctataaatat     3240

aatttatttt gcttggtcta ccctttttcc tttcatatgg ttttaattca ggtaaaaatc     3300

cattttgtat ttctcttaag tcataaatat attcgtactc atctaatata ttgactactg     3360

tttttgattt agagtttata cttcctggaa ctcttaatat tctcgttgca tctaaggctt     3420

gtctatctgc tccaaagtat tttaattgat tatataaata ttcttgaacc gctttccata     3480

atggtaatgc tttactaggt actgcattta ttatccatat taaatacatt cctcttccac     3540

tatctattac atagtttggt ataggaatac tttgattaaa ataattcttt tctaagtcca     3600

ttaatacctg gtctttagtt ttgccagttt tataataatc caagtctata aacagtgtat     3660

ttaactcttt tatattttct aatcgcctac acggcttata aaaggtattt agagttatat     3720

agatattttc atcactcata tctaaatctt ttaattcagc gtatttatag tgccattggc     3780

tatatccttt tttatctata acgctcctgg ttatccaccc tttacttcta ctatgaatat     3840

tatctatata gttcttttta ttcagcttta atgcgtttct cacttattca cctccccttc     3900

tgtaaaacta agaaaattat atcatatttt caataattat taactattct taaactctta     3960

ataaaaaata gagtaagtcc ccaattgaaa cttaatctat tttttatgtt ttaatttatt     4020

atttttatta aaatatttta aactaaatta aatgattctt tttaattttt tactatttca     4080

ttccataata tattactata attatttaca aataatattt cttcatttgt aatatttaga     4140

tgatttacta attttagttt ttatatatta aataattaat gtataattta tataaaaaat     4200

caaaggagct tataaattat gattatttcc aaagatacta aagatttaat ttttttcaat     4260

tttaacaata ctttttgtaa tattatgttt aaatttaatt gtattttttt catataataa     4320

agccgttgaa gtaaaccaat ccattttcct tatgatgtta ttattaaatt taagttttat     4380

aataatatct ttattatatt tattgttttt aaaaaaacta gtgaaatttc tagtgaaatt     4440

tccggcttta ttaaacttat ttttaggaat tttattttca ttttcatctt tacaggattt     4500

gattatatct ttaaatatgt tttatcaaat attatctttt tctaaattta tatatatttt     4560

tattatattt attattatat atattttatt tttaagtttc tttctaacag ctattaaaaa     4620

gaaacttaaa aataaaaaca cgtactctaa accaataaat aaaactattt ttattattgc     4680

tgccttgatt ggaatagttt ttagtaaaat taatttcaat attccacaat attatattat     4740

aagctagcac gcctcgagac tctatcattg atagagtttg aaactctatc attgatagag     4800

tataatatct ttgttcatgc ttattacgac ataacacagt tttagagcta gaaatagcaa     4860

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt     4920

tgaagcttct cgagatctcc atggacgcgt gacgtcgacc ttctaatctc ctctactatt     4980

ttagggttag ctacattagc taaataggta atagctacag ttgtctttga attctcacct     5040

aaagtaagtt cttccacttt aaaatcagtg cttctaattt tttttcttaa aagggctaca     5100

tttgtggtta aagattcagt gaagccctct ctaggacctc ttattacagt ttcaacagtt     5160

ggttctgtta tagctctttc agggggtttt ccaatactta taataattgc tttactttca     5220

ccatctagga ataatgctat acttcctttt aaaatggaca atataacatc atccatgctt     5280

ttatatacat ttttatcatt aacagcaaaa attgattttg tatattcaaa tatgtttaaa     5340

tggggatggt tattgtaatc ttcttctata agttttttta taacagagga ttctattaca     5400

tcagattgga taagattatt tatgtagaca atcattgcag aaaaatttct attattagct     5460

attttaaatt ctctaatcgt taaatctgag caatttgtaa ataaggtttc tatagtatgt     5520

ttatttgttt taaggctagt tgaaaccgtc ttcgcgttat ttttagatgc ttcttcttta     5580

ttaaaaattt tattaaacaa cgaaaaattc accccctcaa tttatttata taatagtagt     5640

ttgcatgaaa tttcgttgtt tattcatatt agatgcttgt attaaaataa taaaatagta     5700

aaatataagt agacaaacta taaatctatt actaggaggt aagaagtatg ctaagtttta     5760

aatctgtgta aacctaccgg ggtttgggcg tagccattat attcatgaac tccaagaaag     5820

cagtatgcta gcaaagaaat aaaactcaaa gcagagagaa aatttagaca ttcaactata     5880

aataaaaaat accccccaaa gcattaatat cttggggagt attttttatt ttgaagtatt     5940

ctgttcagct aaatattctt ctaaggtaat acctctgttc ataatttctt gtgaggcagg     6000

aagaccgata tatcttacat gccatggctc aaaattatac tttgttatgt tttctttatc     6060

cttaggatat cttattatga aaccatattt accacaattt tgttgaagcc atttataaga     6120

atttgtattc ataaatccat catctaaaga agagtattcg gttgatagta agtccattgc     6180

caatccagtt tgatgctcac ttgtaccagg ttcagctaca tatttatcag cttcggcttt     6240

tccgtctcgt gctacttttt cattatataa tttttgctga tacgaataag gtctataacc     6300

tgaaacagct agaagtgtaa gaccatcctt tgatgctgca ttaaacatat tttcaagtcc     6360

tgttgcagct tcgctctcca tttgatttac attaggatca gaactactaa taaatttaac     6420

gttaggagtt ctcaaatttt gaggtatata gtttcctgat aatttacttt gcttgtttac     6480

aagtaggatg ttctgtttct ttacctcggg tttcttggct tgttttttag gtgtagaaac     6540

tttctttttg ggttcgtttg                                                 6560


<210>  81
<211>  1654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cassette bgaR acrIIA4

<400>  81
aaaaagtata acagaggttt taatttacgc ctctgttata ctttttattt ttgaaatttt       60

tttgttttaa agctgtattt taaatttata tacttggttt atttacttga ttatttctgt      120

aatttagtgg agacattgaa aaatgttttg aaaaagtttt tgaaaataac agggagtcac      180

tataacctac actacttgcg acttctccta taggaagttt agtgcttttt aataaaaggg      240

tggctttgta cattctaagg tttattaaat atctttgagg agaaattcca aggtttttta      300

tgaacatttt atataaataa cttctactta agttcacata atcagcaatt tcttgaacag      360

ttatgctatg catgtaatta gaattaatga aattaagagc atcttgaata tatgtgtgta      420

attccttatc tttgtattca aaaggttttg ggaattcttc tataagtgcg tacaataatg      480

agtaaagttc ttttagtaat agtatgtcat cagatcttga aggattataa gtttttgata      540

tttcgcacat atttaatatt atctgtggaa tttttgagtt ttcttcacaa ttagcaacac      600

aggagttagt aatagaagtt ctatttaaat actcattagc atttgaacca ctaaatccta      660

tccagtagta ttcccaagga tcatcaatag aagccacata ctcaacttgc atacctttta      720

gtagtataaa aatatcacct tgttttaagt tatatacctt accattaaat ttaaaagttc      780

catatccctt agttacgtaa tgaataacag catttttcaa tacttcatag ttatatccta      840

atcctggtat accttgttct ataccacatt catctacatt catttcaaag ttttctttaa      900

catacttttt ccacaatatt tgcatttcta cctcctaacc tataaaatta gccaatttta      960

tagtagtctt atattaaaca tttacatgag agctttgcaa agcagtttat caacataaaa     1020

gctttttatt ttaaaataaa ttcttctaaa tataagaata ttttaaagaa atatctttat     1080

atattagtta ttaaaattta taagattata agaaacatta taacatattt tagaactttt     1140

taactattct aaaagattaa tttacatatt aacatttaat tatgggtaaa aactattttg     1200

aaaaatgatt tatatggaat tatgtttctt aaatatacaa tcatgtttca tgaatacata     1260

attattttaa atgtattggg agggtaaaat gatattaaaa aatgaatacc atgaagatac     1320

tgcagaatct agaatccgcg gtagtcgacg tggaattgtg agcggataac aatttcacag     1380

gagggctgaa atgaatatta atgacttaat tagagaaata aaaaacaaag attacacagt     1440

gaaattgagt ggtacggata gcaatagtat aacacagcta attattagag ttaataatga     1500

tggaaacgag tatgtaattt ctgaaagtga aaatgaatca atagttgaaa aattcatatc     1560

tgcatttaaa aacggttgga atcaagaata cgaggatgaa gaagaatttt ataatgacat     1620

gcaaacaatc accttaaaaa gtgagttgaa ctaa                                 1654


<210>  82
<211>  4984
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNAind

<400>  82
caagcttcaa aaaaagcacc gactcggtgc cactttttca agttgataac ggactagcct       60

tattttaact tgctatttct agctctaaaa cagagaccgc tagcgatatc cccgggagat      120

ctggtctcaa tgaacaaaga tattatactc tatcaatgat agagtttcaa actctatcaa      180

tgatagagtg agctcgaatt cgtaatcatg gtcatagctg tttcctgtgt gaaattgtta      240

tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag cctggggtgc      300

ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt tccagtcggg      360

aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag gcggtttgcg      420

tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg ttcggctgcg      480

gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat caggggataa      540

cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc      600

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc      660

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag      720

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct      780

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta      840

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc      900

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc      960

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     1020

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     1080

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     1140

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     1200

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     1260

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     1320

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaaag     1380

ctagcttaat actagtatat acttaatgtg ataagtgtct gacagctgac cggtctaaag     1440

aggtccctag cgcctacggg gaatttgtat cgataagggg tacaaattcc cactaagcgc     1500

tcggccgggg atcgatcccc gggtacgtac ccggcagttt ttctttttcg gcaagtgttc     1560

aagaagttat taagtcggga gtgcagtcga agtgggcaag ttgaaaaatt cacaaaaatg     1620

tggtataata tctttgttca ttagagcgat aaacttgaat ttgagaggga acttagatgg     1680

tatttgaaaa aattgataaa aatagttgga acagaaaaga gtattttgac cactactttg     1740

caagtgtacc ttgtacctac agcatgaccg ttaaagtgga tatcacacaa ataaaggaaa     1800

agggaatgaa actatatcct gcaatgcttt attatattgc aatgattgta aaccgccatt     1860

cagagtttag gacggcaatc aatcaagatg gtgaattggg gatatatgat gagatgatac     1920

caagctatac aatatttcac aatgatactg aaacattttc cagcctttgg actgagtgta     1980

agtctgactt taaatcattt ttagcagatt atgaaagtga tacgcaacgg tatggaaaca     2040

atcatagaat ggaaggaaag ccaaatgctc cggaaaacat ttttaatgta tctatgatac     2100

cgtggtcaac cttcgatggc tttaatctga atttgcagaa aggatatgat tatttgattc     2160

ctatttttac tatggggaaa tattataaag aagataacaa aattatactt cctttggcaa     2220

ttcaagttca tcacgcagta tgtgacggat ttcacatttg ccgttttgta aacgaattgc     2280

aggaattgat aaatagttaa cttcaggttt gtctgtaact aaaaactagt atttaaccta     2340

ggatcaaaaa aatttccaat aatcccactc taagccacaa acacgcccta taaaatcccg     2400

ctttaatccc actttgagac acatgtaata ttactttacg ccctagtata gtgataattt     2460

tttacattca atgccacgca aaaaaataaa ggggcactat aataaaagtt ccttcggaac     2520

taactaaagt aaaaaattat ctttacaacc tccccaaaaa aaagaacagg tacaaagtac     2580

cctataatac aagcgtaaaa aaaatgaggg taaaaataaa aaaataaaaa aataaaaaaa     2640

taaaaaaata aaaaaataaa aaaataaaaa aatataaaaa taaaaaaata taaaaataaa     2700

aaaatataaa aataaaaaaa taaaaaaata taaaaataaa aaaataaaaa aatataaaaa     2760

tattttttat ttaaagtttg aaaaaaattt ttttatatta tataatcttt gaagaaaaga     2820

atataaaaaa tgagccttta taaaagccca ttttttttca tatacgtaat atgacgttct     2880

aatgttttta ttggtacttc taacattaga gtaatttctt tatttttaaa gcctttttct     2940

ttaagggctt ttattttttt tcttaataca tttaattcct ctttttttgt tgcttttcct     3000

ttagctttta attgctcttg ataatttttt ttacctctaa tattttctct tctcttatat     3060

tcctttttag aaattattat tgtcatatat ttttgttctt cttctgtaat ttctaataac     3120

tctataagag tttcattctt atacttatat tgcttatttt tatctaaata acatctttca     3180

gcacttctag ttgctcttat aacttctctt tcacttaaat gttgtctaaa catactatta     3240

agttctaaaa catcatttaa tgccttctca atgtcttctg taaagctaca aagataatat     3300

ctatataaaa ataatataag ctctctgtgt ccttttaaat catattctct tagttcacaa     3360

agttttatta tgtcttgtat tcttccataa tataaacttc tttctctata aatataattt     3420

attttgcttg gtctaccctt tttcctttca tatggtttta attcaggtaa aaatccattt     3480

tgtatttctc ttaagtcata aatatattcg tactcatcta atatattgac tactgttttt     3540

gatttagagt ttatacttcc tggaactctt aatattctcg ttgcatctaa ggcttgtcta     3600

tctgctccaa agtattttaa ttgattatat aaatattctt gaaccgcttt ccataatggt     3660

aatgctttac taggtactgc atttattatc catattaaat acattcctct tccactatct     3720

attacatagt ttggtatagg aatactttga ttaaaataat tcttttctaa gtccattaat     3780

acctggtctt tagttttgcc agttttataa taatccaagt ctataaacag tgtatttaac     3840

tcttttatat tttctaatcg cctacacggc ttataaaagg tatttagagt tatatagata     3900

ttttcatcac tcatatctaa atcttttaat tcagcgtatt tatagtgcca ttggctatat     3960

ccttttttat ctataacgct cctggttatc caccctttac ttctactatg aatattatct     4020

atatagttct ttttattcag ctttaatgcg tttctcactt attcacctcc ccttctgtaa     4080

aactaagaaa attatatcat attttcaata attattaact attcttaaac tcttaataaa     4140

aaatagagta agtccccaat tgaaacttaa tctatttttt atgttttaat ttattatttt     4200

tattaaaata ttttaaacta aattaaatga ttctttttaa ttttttacta tttcattcca     4260

taatatatta ctataattat ttacaaataa tatttcttca tttgtaatat ttagatgatt     4320

tactaatttt agtttttata tattaaataa ttaatgtata atttatataa aaaatcaaag     4380

gagcttataa attatgatta tttccaaaga tactaaagat ttaatttttt tcaattttaa     4440

caatactttt tgtaatatta tgtttaaatt taattgtatt tttttcatat aataaagccg     4500

ttgaagtaaa ccaatccatt ttccttatga tgttattatt aaatttaagt tttataataa     4560

tatctttatt atatttattg tttttaaaaa aactagtgaa atttctagtg aaatttccgg     4620

ctttattaaa cttattttta ggaattttat tttcattttc atctttacag gatttgatta     4680

tatctttaaa tatgttttat caaatattat ctttttctaa atttatatat atttttatta     4740

tatttattat tatatatatt ttatttttaa gtttctttct aacagctatt aaaaagaaac     4800

ttaaaaataa aaacacgtac tctaaaccaa taaataaaac tatttttatt attgctgcct     4860

tgattggaat agtttttagt aaaattaatt tcaatattcc acaatattat attataagct     4920

agcacgcctc gagatctcca tggacgcgtg acgtcgactc tagaggatcc ccgggtaccg     4980

agct                                                                  4984


<210>  83
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cassette ARNg

<400>  83
gagctcactc tatcattgat agagtttgaa actctatcat tgatagagta taatatcttt       60

gttcattgag accagatctc ccggggatat cgctagcggt ctctgtttta gagctagaaa      120

tagcaagtta aaataaggct agtccgttat caacttgaaa aagtggcacc gagtcggtgc      180

tttttttgaa gcttgagctc                                                  200


<210>  84
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  84
tcatgatttc tccatattag ctag                                              24


<210>  85
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  85
aaacctagct aatatggaga aatc                                              24


<210>  86
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
tcatgttaca cttggaacag gcgt                                              24


<210>  87
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
aaacacgcct gttccaagtg taac                                              24


<210>  88
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
tcatttccgg cagtaggatc ccca                                              24


<210>  89
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
aaactgggga tcctactgcc ggaa                                              24


<210>  90
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
tcatgcttat tacgacataa caca                                              24


<210>  91
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
aaactgtgtt atgtcgtaat aagc                                              24


<210>  92
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
atgcatggat ccaaacgaac ccaaaaagaa agtttc                                 36


<210>  93
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
ggttgatttc aaatctgtgt aaacctaccg                                        30


<210>  94
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
acacagattt gaaatcaacc actttaaccc                                        30


<210>  95
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
atgcatgtcg actcttaaga acatgtataa agtatgg                                37


<210>  96
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
atgcatggat ccaaacgaac ccaaaaagaa agtttc                                 36


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
gctaagtttt aaatctgtgt aaacctaccg                                        30


<210>  98
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  98
acacagattt aaaacttagc atacttctta cc                                     32


<210>  99
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
atgcatgtcg accttctaat ctcctctact attttag                                37


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
acacattgaa gggagctttt                                                   20


<210>  101
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
ggcaacaaca tcaggccttt                                                   20


<210>  102
<211>  4966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-xylB

<400>  102
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gaagcttcaa aaaaagcacc gactcggtgc cactttttca agttgataac     2640

ggactagcct tattttaact tgctatttct agctctaaaa cctagctaat atggagaaat     2700

catgaacaaa gatattatac tctatcaatg atagagtttc aaactctatc aatgatagag     2760

tctcgagatc tccatggacg cgtgacgtcg actctagagg atccccgggt accgagctcg     2820

aattcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     2880

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     2940

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     3000

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     3060

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     3120

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3180

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3240

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3300

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3360

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3420

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3480

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3540

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3600

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3660

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3720

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3780

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3840

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     3900

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     3960

atctaaagta tatatgagta aacttggtct gacagttacc aaagctagct taatactagt     4020

atatacttaa tgtgataagt gtctgacagc tgaccggtct aaagaggtcc ctagcgccta     4080

cggggaattt gtatcgataa ggggtacaaa ttcccactaa gcgctcggcc ggggatcgat     4140

ccccgggtac gtacccggca gtttttcttt ttcggcaagt gttcaagaag ttattaagtc     4200

gggagtgcag tcgaagtggg caagttgaaa aattcacaaa aatgtggtat aatatctttg     4260

ttcattagag cgataaactt gaatttgaga gggaacttag atggtatttg aaaaaattga     4320

taaaaatagt tggaacagaa aagagtattt tgaccactac tttgcaagtg taccttgtac     4380

ctacagcatg accgttaaag tggatatcac acaaataaag gaaaagggaa tgaaactata     4440

tcctgcaatg ctttattata ttgcaatgat tgtaaaccgc cattcagagt ttaggacggc     4500

aatcaatcaa gatggtgaat tggggatata tgatgagatg ataccaagct atacaatatt     4560

tcacaatgat actgaaacat tttccagcct ttggactgag tgtaagtctg actttaaatc     4620

atttttagca gattatgaaa gtgatacgca acggtatgga aacaatcata gaatggaagg     4680

aaagccaaat gctccggaaa acatttttaa tgtatctatg ataccgtggt caaccttcga     4740

tggctttaat ctgaatttgc agaaaggata tgattatttg attcctattt ttactatggg     4800

gaaatattat aaagaagata acaaaattat acttcctttg gcaattcaag ttcatcacgc     4860

agtatgtgac ggatttcaca tttgccgttt tgtaaacgaa ttgcaggaat tgataaatag     4920

ttaacttcag gtttgtctgt aactaaaaac tagtatttaa cctagg                    4966


<210>  103
<211>  4966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-xylR

<400>  103
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gactctatca ttgatagagt ttgaaactct atcattgata gagtataata     2640

tctttgttca tgttacactt ggaacaggcg tgttttagag ctagaaatag caagttaaaa     2700

taaggctagt ccgttatcaa cttgaaaaag tggcaccgag tcggtgcttt ttttgaagct     2760

tctcgagatc tccatggacg cgtgacgtcg actctagagg atccccgggt accgagctcg     2820

aattcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct cacaattcca     2880

cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg agtgagctaa     2940

ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct gtcgtgccag     3000

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     3060

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     3120

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3180

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3240

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3300

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3360

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3420

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3480

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3540

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3600

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3660

tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3720

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3780

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3840

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     3900

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     3960

atctaaagta tatatgagta aacttggtct gacagttacc aaagctagct taatactagt     4020

atatacttaa tgtgataagt gtctgacagc tgaccggtct aaagaggtcc ctagcgccta     4080

cggggaattt gtatcgataa ggggtacaaa ttcccactaa gcgctcggcc ggggatcgat     4140

ccccgggtac gtacccggca gtttttcttt ttcggcaagt gttcaagaag ttattaagtc     4200

gggagtgcag tcgaagtggg caagttgaaa aattcacaaa aatgtggtat aatatctttg     4260

ttcattagag cgataaactt gaatttgaga gggaacttag atggtatttg aaaaaattga     4320

taaaaatagt tggaacagaa aagagtattt tgaccactac tttgcaagtg taccttgtac     4380

ctacagcatg accgttaaag tggatatcac acaaataaag gaaaagggaa tgaaactata     4440

tcctgcaatg ctttattata ttgcaatgat tgtaaaccgc cattcagagt ttaggacggc     4500

aatcaatcaa gatggtgaat tggggatata tgatgagatg ataccaagct atacaatatt     4560

tcacaatgat actgaaacat tttccagcct ttggactgag tgtaagtctg actttaaatc     4620

atttttagca gattatgaaa gtgatacgca acggtatgga aacaatcata gaatggaagg     4680

aaagccaaat gctccggaaa acatttttaa tgtatctatg ataccgtggt caaccttcga     4740

tggctttaat ctgaatttgc agaaaggata tgattatttg attcctattt ttactatggg     4800

gaaatattat aaagaagata acaaaattat acttcctttg gcaattcaag ttcatcacgc     4860

agtatgtgac ggatttcaca tttgccgttt tgtaaacgaa ttgcaggaat tgataaatag     4920

ttaacttcag gtttgtctgt aactaaaaac tagtatttaa cctagg                    4966


<210>  104
<211>  4966
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-glcG

<400>  104
agctcggtac ccggggatcc tctagagtcg acgtcacgcg tccatggaga tctcgaggcg       60

tgctagctta taatataata ttgtggaata ttgaaattaa ttttactaaa aactattcca      120

atcaaggcag caataataaa aatagtttta tttattggtt tagagtacgt gtttttattt      180

ttaagtttct ttttaatagc tgttagaaag aaacttaaaa ataaaatata tataataata      240

aatataataa aaatatatat aaatttagaa aaagataata tttgataaaa catatttaaa      300

gatataatca aatcctgtaa agatgaaaat gaaaataaaa ttcctaaaaa taagtttaat      360

aaagccggaa atttcactag aaatttcact agttttttta aaaacaataa atataataaa      420

gatattatta taaaacttaa atttaataat aacatcataa ggaaaatgga ttggtttact      480

tcaacggctt tattatatga aaaaaataca attaaattta aacataatat tacaaaaagt      540

attgttaaaa ttgaaaaaaa ttaaatcttt agtatctttg gaaataatca taatttataa      600

gctcctttga ttttttatat aaattataca ttaattattt aatatataaa aactaaaatt      660

agtaaatcat ctaaatatta caaatgaaga aatattattt gtaaataatt atagtaatat      720

attatggaat gaaatagtaa aaaattaaaa agaatcattt aatttagttt aaaatatttt      780

aataaaaata ataaattaaa acataaaaaa tagattaagt ttcaattggg gacttactct      840

attttttatt aagagtttaa gaatagttaa taattattga aaatatgata taattttctt      900

agttttacag aaggggaggt gaataagtga gaaacgcatt aaagctgaat aaaaagaact      960

atatagataa tattcatagt agaagtaaag ggtggataac caggagcgtt atagataaaa     1020

aaggatatag ccaatggcac tataaatacg ctgaattaaa agatttagat atgagtgatg     1080

aaaatatcta tataactcta aatacctttt ataagccgtg taggcgatta gaaaatataa     1140

aagagttaaa tacactgttt atagacttgg attattataa aactggcaaa actaaagacc     1200

aggtattaat ggacttagaa aagaattatt ttaatcaaag tattcctata ccaaactatg     1260

taatagatag tggaagagga atgtatttaa tatggataat aaatgcagta cctagtaaag     1320

cattaccatt atggaaagcg gttcaagaat atttatataa tcaattaaaa tactttggag     1380

cagatagaca agccttagat gcaacgagaa tattaagagt tccaggaagt ataaactcta     1440

aatcaaaaac agtagtcaat atattagatg agtacgaata tatttatgac ttaagagaaa     1500

tacaaaatgg atttttacct gaattaaaac catatgaaag gaaaaagggt agaccaagca     1560

aaataaatta tatttataga gaaagaagtt tatattatgg aagaatacaa gacataataa     1620

aactttgtga actaagagaa tatgatttaa aaggacacag agagcttata ttatttttat     1680

atagatatta tctttgtagc tttacagaag acattgagaa ggcattaaat gatgttttag     1740

aacttaatag tatgtttaga caacatttaa gtgaaagaga agttataaga gcaactagaa     1800

gtgctgaaag atgttattta gataaaaata agcaatataa gtataagaat gaaactctta     1860

tagagttatt agaaattaca gaagaagaac aaaaatatat gacaataata atttctaaaa     1920

aggaatataa gagaagagaa aatattagag gtaaaaaaaa ttatcaagag caattaaaag     1980

ctaaaggaaa agcaacaaaa aaagaggaat taaatgtatt aagaaaaaaa ataaaagccc     2040

ttaaagaaaa aggctttaaa aataaagaaa ttactctaat gttagaagta ccaataaaaa     2100

cattagaacg tcatattacg tatatgaaaa aaaatgggct tttataaagg ctcatttttt     2160

atattctttt cttcaaagat tatataatat aaaaaaattt ttttcaaact ttaaataaaa     2220

aatattttta tattttttta tttttttatt tttatatttt tttatttttt tatttttata     2280

tttttttatt tttatatttt tttattttta tattttttta tttttttatt tttttatttt     2340

tttatttttt tattttttta tttttttatt tttaccctca ttttttttac gcttgtatta     2400

tagggtactt tgtacctgtt cttttttttg gggaggttgt aaagataatt ttttacttta     2460

gttagttccg aaggaacttt tattatagtg cccctttatt tttttgcgtg gcattgaatg     2520

taaaaaatta tcactatact agggcgtaaa gtaatattac atgtgtctca aagtgggatt     2580

aaagcgggat tttatagggc gtgtttgtgg cttagagtgg gattattgga aatttttttg     2640

atcctaggtt aaatactagt ttttagttac agacaaacct gaagttaact atttatcaat     2700

tcctgcaatt cgtttacaaa acggcaaatg tgaaatccgt cacatactgc gtgatgaact     2760

tgaattgcca aaggaagtat aattttgtta tcttctttat aatatttccc catagtaaaa     2820

ataggaatca aataatcata tcctttctgc aaattcagat taaagccatc gaaggttgac     2880

cacggtatca tagatacatt aaaaatgttt tccggagcat ttggctttcc ttccattcta     2940

tgattgtttc cataccgttg cgtatcactt tcataatctg ctaaaaatga tttaaagtca     3000

gacttacact cagtccaaag gctggaaaat gtttcagtat cattgtgaaa tattgtatag     3060

cttggtatca tctcatcata tatccccaat tcaccatctt gattgattgc cgtcctaaac     3120

tctgaatggc ggtttacaat cattgcaata taataaagca ttgcaggata tagtttcatt     3180

cccttttcct ttatttgtgt gatatccact ttaacggtca tgctgtaggt acaaggtaca     3240

cttgcaaagt agtggtcaaa atactctttt ctgttccaac tatttttatc aattttttca     3300

aataccatct aagttccctc tcaaattcaa gtttatcgct ctaatgaaca aagatattat     3360

accacatttt tgtgaatttt tcaacttgcc cacttcgact gcactcccga cttaataact     3420

tcttgaacac ttgccgaaaa agaaaaactg ccgggtacgt acccggggat cgatccccgg     3480

ccgagcgctt agtgggaatt tgtacccctt atcgatacaa attccccgta ggcgctaggg     3540

acctctttag accggtcagc tgtcagacac ttatcacatt aagtatatac tagtattaag     3600

ctagctttgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     3660

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     3720

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     3780

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     3840

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     3900

cttcagcaga gcgcagatac caaatactgt tcttctagtg tagccgtagt taggccacca     3960

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     4020

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     4080

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     4140

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     4200

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     4260

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     4320

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     4380

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     4440

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     4500

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     4560

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct ggcacgacag     4620

gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt agctcactca     4680

ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg gaattgtgag     4740

cggataacaa tttcacacag gaaacagcta tgaccatgat tacgaattcg agctcactct     4800

atcattgata gagtttgaaa ctctatcatt gatagagtat aatatctttg ttcatttccg     4860

gcagtaggat ccccagtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta     4920

tcaacttgaa aaagtggcac cgagtcggtg ctttttttga agcttg                    4966


<210>  105
<211>  4938
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGRNA-bdhB

<400>  105
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gtatattgat aaaaataata atagtgggta taattaagtt gttaggaggt     2640

tagttagagc ttattacgac ataacacagt tttagagcta gaaatagcaa gttaaaataa     2700

ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt tgaagcttgt     2760

cgactctaga ggatccccgg gtaccgagct cgaattcgta atcatggtca tagctgtttc     2820

ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt     2880

gtaaagcctg gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc     2940

ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg     3000

ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc gctcactgac tcgctgcgct     3060

cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa ggcggtaata cggttatcca     3120

cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga     3180

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     3240

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     3300

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     3360

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     3420

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     3480

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     3540

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg     3600

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg     3660

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg     3720

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca     3780

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga     3840

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga     3900

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt     3960

ctgacagtta ccaaagctag cttaatacta gtatatactt aatgtgataa gtgtctgaca     4020

gctgaccggt ctaaagaggt ccctagcgcc tacggggaat ttgtatcgat aaggggtaca     4080

aattcccact aagcgctcgg ccggggatcg atccccgggt acgtacccgg cagtttttct     4140

ttttcggcaa gtgttcaaga agttattaag tcgggagtgc agtcgaagtg ggcaagttga     4200

aaaattcaca aaaatgtggt ataatatctt tgttcattag agcgataaac ttgaatttga     4260

gagggaactt agatggtatt tgaaaaaatt gataaaaata gttggaacag aaaagagtat     4320

tttgaccact actttgcaag tgtaccttgt acctacagca tgaccgttaa agtggatatc     4380

acacaaataa aggaaaaggg aatgaaacta tatcctgcaa tgctttatta tattgcaatg     4440

attgtaaacc gccattcaga gtttaggacg gcaatcaatc aagatggtga attggggata     4500

tatgatgaga tgataccaag ctatacaata tttcacaatg atactgaaac attttccagc     4560

ctttggactg agtgtaagtc tgactttaaa tcatttttag cagattatga aagtgatacg     4620

caacggtatg gaaacaatca tagaatggaa ggaaagccaa atgctccgga aaacattttt     4680

aatgtatcta tgataccgtg gtcaaccttc gatggcttta atctgaattt gcagaaagga     4740

tatgattatt tgattcctat ttttactatg gggaaatatt ataaagaaga taacaaaatt     4800

atacttcctt tggcaattca agttcatcac gcagtatgtg acggatttca catttgccgt     4860

tttgtaaacg aattgcagga attgataaat agttaacttc aggtttgtct gtaactaaaa     4920

actagtattt aacctagg                                                   4938


<210>  106
<211>  4790
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEC750C

<400>  106
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gatctccatg gacgcgtgac gtcgactcta gaggatcccc gggtaccgag     2640

ctcgaattcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     2700

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     2760

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     2820

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     2880

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     2940

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     3000

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     3060

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     3120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     3180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     3240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     3300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     3360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     3420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     3480

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     3540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     3600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     3660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     3720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     3780

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaaagct agcttaatac     3840

tagtatatac ttaatgtgat aagtgtctga cagctgaccg gtctaaagag gtccctagcg     3900

cctacgggga atttgtatcg ataaggggta caaattccca ctaagcgctc ggccggggat     3960

cgatccccgg gtacgtaccc ggcagttttt ctttttcggc aagtgttcaa gaagttatta     4020

agtcgggagt gcagtcgaag tgggcaagtt gaaaaattca caaaaatgtg gtataatatc     4080

tttgttcatt agagcgataa acttgaattt gagagggaac ttagatggta tttgaaaaaa     4140

ttgataaaaa tagttggaac agaaaagagt attttgacca ctactttgca agtgtacctt     4200

gtacctacag catgaccgtt aaagtggata tcacacaaat aaaggaaaag ggaatgaaac     4260

tatatcctgc aatgctttat tatattgcaa tgattgtaaa ccgccattca gagtttagga     4320

cggcaatcaa tcaagatggt gaattgggga tatatgatga gatgatacca agctatacaa     4380

tatttcacaa tgatactgaa acattttcca gcctttggac tgagtgtaag tctgacttta     4440

aatcattttt agcagattat gaaagtgata cgcaacggta tggaaacaat catagaatgg     4500

aaggaaagcc aaatgctccg gaaaacattt ttaatgtatc tatgataccg tggtcaacct     4560

tcgatggctt taatctgaat ttgcagaaag gatatgatta tttgattcct atttttacta     4620

tggggaaata ttataaagaa gataacaaaa ttatacttcc tttggcaatt caagttcatc     4680

acgcagtatg tgacggattt cacatttgcc gttttgtaaa cgaattgcag gaattgataa     4740

atagttaact tcaggtttgt ctgtaactaa aaactagtat ttaacctagg                4790


<210>  107
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
acttgggtcg accacgataa aacaaggttt taagg                                  35


<210>  108
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
taccagggat ccgtattaat gtaactatga tatcaattct tg                          42


<210>  109
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  109
atgcatggtc ccaatgaata ggtttacact tactttagtt ttatgg                      46


<210>  110
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  110
atgcgagtta acaacttcta aaatctgatt accaattag                              39


<210>  111
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  111
atgcatggat cccaatgaat aggtttacac ttactttagt tttatgg                     47


<210>  112
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  112
atgcgagagc tcaacttcta aaatctgatt accaattag                              39


<210>  113
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  113
atgcatggat ccgtctgaca gttaccaggt cc                                     32


<210>  114
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  114
atgcgagagc tccaattgtt caaaaaaata atggcggag                              39


<210>  115
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  115
atgcatggat cccggcagtt tttctttttc gg                                     32


<210>  116
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  116
atgcgagagc tcggttaaat actagttttt agttacagac                             40


<210>  117
<211>  2686
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pUC19

<400>  117
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca       60

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct      120

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat      180

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcttgc      240

atgcctgcag gtcgactcta gaggatcccc gggtaccgag ctcgaattca ctggccgtcg      300

ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac      360

atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac      420

agttgcgcag cctgaatggc gaatggcgcc tgatgcggta ttttctcctt acgcatctgt      480

gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat gccgcatagt      540

taagccagcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct tgtctgctcc      600

cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt cagaggtttt      660

caccgtcatc accgaaacgc gcgagacgaa agggcctcgt gatacgccta tttttatagg      720

ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc      780

gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac      840

aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt      900

tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag      960

aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg     1020

aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa     1080

tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc     1140

aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag     1200

tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa     1260

ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc     1320

taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg     1380

agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa     1440

caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg caacaattaa     1500

tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg     1560

gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag     1620

cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg     1680

caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt     1740

ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt     1800

aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac     1860

gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag     1920

atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg     1980

tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca     2040

gagcgcagat accaaatact gttcttctag tgtagccgta gttaggccac cacttcaaga     2100

actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca     2160

gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc     2220

agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca     2280

ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa     2340

aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc     2400

cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc     2460

gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg     2520

cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat     2580

cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca     2640

gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaaga                    2686


<210>  118
<211>  4282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNF2

<400>  118
ctggagagga ttgtccttat acttatcata agcatgaagg acttgttatt cctagataga       60

gaattaatta tgttaaagag atataataaa ctcattataa ttataatttt tagtataatt      120

attattgcaa ttttttcgta taaatatcta ataatgccaa aagagcatag aatagaaatt      180

tcaacattat caaacataga agtttttaaa tttaatagtt tttcaaagtt tagtaacgaa      240

aaaatgtata ctattaatga tagtgataag ttaataaaat tcaaaacact atttaataat      300

ttagataaat caaaagatat aaaaaagatt agtattccgg aaagtgaaaa tttaaatgca      360

tttaaatttt ctgcacatat aaaacttaac tttaactatg ttaataaaga tagccaaata      420

actgaaggtg cttttcttat gtatattttg gtagacaatt tagaagggaa gtcatatatg      480

acttttttag gacaagattc aagctatata ttagatagta atgaaactaa cattttaaga      540

gaaatattta tgaattcaga gattaattaa tttatgaatt cataaatatt atctaagcac      600

gataaaacaa ggttttaagg ataagaaaag tcatgagatt tatagtaaat cttgtgactt      660

tttttattga atagtagaga gagttcggaa gtataacacg ctatattctt gatattttta      720

gaatagcaag cattggattt gtcctgacac tttcccaaaa attaaggagt tattccttaa      780

accaaaaaga ttaatgtggg aacaaattta gtgtatccat ttttgaaggg cgcacttata      840

caccaccaaa atggtgtgtg cgaaatcttt aaaaaagatt tatcaaaaag cttttttaaa      900

gctgggacat ttagaaaatc aataatgttt tttgcccaat acgctagtct taaaatctgc      960

aaggttgata actatttagt cccaggtatt agaatggggc atatatatac aaagtatata     1020

tatgcgtaaa tatatgtggg actgtgggaa caaaattgcg tgctaaaatt gtattgaaaa     1080

ggtaatgaaa aggtcatgct ttggtattgc taacgtatag aaaaggtaat gaaaagctca     1140

tggttctata aaaaagatgt acccacgaaa ataataggct ttgcctattt ccccatgtaa     1200

tatgggggca gttttctctt atgctctttc ttaacatatt gaataaatac aaaatgcagc     1260

tttgtgggaa taaaaatatt tttgttttta ttcttatagt tagacaaaat tttaatcttt     1320

tttgtgctat aacaagatta aaatttgtgg gaacattaag aaatattgtt gtcacaaata     1380

aaaaggagag tgggaacaat tgctataaaa aacgcagaaa ttaagattag agttacaaaa     1440

gagcaaaaag aattatttaa gaaaattgca aaagctgaaa atatgagtat gagtgaattt     1500

attattgtga ccacagaata tttagccaga aaaaaagatg aaaatatgaa atcaaaagac     1560

atgatcgaga gaagagctgc gaagactgaa gaaaaaatta tgaagctaaa aaagaaacta     1620

aataaaaaca ggtaatatag attacagttt taagcttgtt ttccctatag actagagtaa     1680

atatataaat atacctgtca agggcttata agccccttta gggggtgcgt agcacccttg     1740

acaggtatat ttatatattt tagggtgcca ttaagggaaa caagctttaa aatgccttta     1800

aaggcatttt aaaataaata aaaaaaagat ggtttttacc atctttttta actcccgaaa     1860

gggagttctt tcttttcttg atactatacg taactatttc gatttgccct gaacctaatc     1920

aaagctagat aaattcagta ttagggcata aaaaaacttg ctttttcggg tggaaatctg     1980

tataatttaa attgcttaga taaaaattac caattccata cgaaaggagc aagttttaca     2040

taaggttaaa gccttatgtg aattctcatt taattacatg aataataata acacagaaag     2100

tgaagaatta aaagagcaaa gtcaactatt gcttgacaaa tgcacaaaaa agaaaaagaa     2160

aaatcctaaa tttagtagtt atatagaacc attagtaagc aagaaattat ctgaaagaat     2220

aaaggaatgt ggtgactttt tgcagatgtt atctgattta aaccttgaaa attcgaaact     2280

gcatagagca agtttttgtg gtaacagatt ttgtcctatg tgtagctggc gtattgcttg     2340

taaggatagt ttggaaatat ctattctcat ggagcattta cgcaaagagg aaagcaaaga     2400

atttatcttt ttgaccttaa caactccaaa tgtgaaaggt gcggaccttg ataattccat     2460

aaaagcatac aataaagcat ttaaaaagtt aatggaacgc aaagaggtca agagcatagt     2520

aaaaggctac ataagaaagc tagaagtaac ctataatttg gacaagagtt ccaaatcata     2580

taatacttat cacccacatt tccatgtggt actagcagtc aatagaagtt actttaaaaa     2640

gcaaaatcta tatataaacc atcatagatg gcttagtttg tggcaagagt caactggtga     2700

ttattcgata actcaagttg atgtaagaaa ggctaaaatt aacgattata aagaggttta     2760

tgagcttgct aagtattcgg ctaaggattc cgactattta atcaatagag aagtgtttac     2820

ggtattctac aaatctttaa agggtaaaca ggtacttgta tttagtggat tatttaaaga     2880

cgctcataaa atgtataaga atggagagct agatctgtat aagaagttgg atactatcga     2940

atatgcttat atggtaagtt ataactggct taaaaagaag tatgatactt caaatattag     3000

agaattaact gaggaagaaa agcagaaatt caataaaaat ttaatcgaag atgtggatat     3060

tgagtaggtg ggattatatc tcaccttttt tattgtcttt tcatgttgaa attttgacgc     3120

ttaatgcatg aagtattgac aagtttaaaa attacggttt ttaatcctta gttgattagc     3180

aggattatgg ccggaatgct ccgtccagtc ctgttaagga attaaaattc cctaaaaccc     3240

ttggctatga tttatagcga gaatcgtcaa ttaaaaattt aataggtgct atgaaagtcg     3300

attaataatt aattttaaaa tgcaatatga aacataatta caagaatttg acttttaata     3360

caagaattga tatcatagtt acattaatac atttattttg aagggggaaa atgttttatg     3420

aaaagactac ttaaactacc tattttatca ttattaggat tatttttaat tggatcaact     3480

ccaacattag ctttaactaa agataataat caaaatttag atactatgaa agtaaactta     3540

tatactgaaa cagtagatgt gtttgataaa gatgcattta aacaaacatt tactaataaa     3600

gatataaaat ttctagagga ttctttgaat gcaaaaataa attattcagg taaatctgtt     3660

acagtaacaa tgaaaaacaa aattaagcca tctactaaac aagggcttgt tttatatgta     3720

aatggaaaat cagttaatgt tgattcagat ggcagtataa aagtacctaa agatactaag     3780

aaaatttcta aattaaataa agataaatca atgatggatg gatcaatgat ggataaatca     3840

ttacatgatg agaattgtgt agtatcagat agtttttata atgctgatgt taataatata     3900

aattcaaaag aagcagaagc tgtatttaaa gtaagttctg gtgaattatt agctaaaatg     3960

gatgaaaaag aagatgatta catacaaaag aactcatcta aaattctagc agctgcttat     4020

cataagggat atggggacaa gtactatgaa ggagattggg ttcattgcaa taggtttaat     4080

ggtcaactta cagatgatgt tcactataat tggagaactg gaagtgtttc agaaaaagca     4140

gctgcaatga gaaattttta tggcagtgat tgtcatatag cattagttca agcaggtagt     4200

ggatgtacaa gtataggttc atgcgaatgc aatacagatc aaatagctgc gtattgttca     4260

ggtttcgtaa aagataaaaa ta                                              4282


<210>  119
<211>  5473
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNF3

<400>  119
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca       60

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct      120

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat      180

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcttgc      240

atgcctgcag gtcgaccacg ataaaacaag gttttaagga taagaaaagt catgagattt      300

atagtaaatc ttgtgacttt ttttattgaa tagtagagag agttcggaag tataacacgc      360

tatattcttg atatttttag aatagcaagc attggatttg tcctgacact ttcccaaaaa      420

ttaaggagtt attccttaaa ccaaaaagat taatgtggga acaaatttag tgtatccatt      480

tttgaagggc gcacttatac accaccaaaa tggtgtgtgc gaaatcttta aaaaagattt      540

atcaaaaagc ttttttaaag ctgggacatt tagaaaatca ataatgtttt ttgcccaata      600

cgctagtctt aaaatctgca aggttgataa ctatttagtc ccaggtatta gaatggggca      660

tatatataca aagtatatat atgcgtaaat atatgtggga ctgtgggaac aaaattgcgt      720

gctaaaattg tattgaaaag gtaatgaaaa ggtcatgctt tggtattgct aacgtataga      780

aaaggtaatg aaaagctcat ggttctataa aaaagatgta cccacgaaaa taataggctt      840

tgcctatttc cccatgtaat atgggggcag ttttctctta tgctctttct taacatattg      900

aataaataca aaatgcagct ttgtgggaat aaaaatattt ttgtttttat tcttatagtt      960

agacaaaatt ttaatctttt ttgtgctata acaagattaa aatttgtggg aacattaaga     1020

aatattgttg tcacaaataa aaaggagagt gggaacaatt gctataaaaa acgcagaaat     1080

taagattaga gttacaaaag agcaaaaaga attatttaag aaaattgcaa aagctgaaaa     1140

tatgagtatg agtgaattta ttattgtgac cacagaatat ttagccagaa aaaaagatga     1200

aaatatgaaa tcaaaagaca tgatcgagag aagagctgcg aagactgaag aaaaaattat     1260

gaagctaaaa aagaaactaa ataaaaacag gtaatataga ttacagtttt aagcttgttt     1320

tccctataga ctagagtaaa tatataaata tacctgtcaa gggcttataa gcccctttag     1380

ggggtgcgta gcacccttga caggtatatt tatatatttt agggtgccat taagggaaac     1440

aagctttaaa atgcctttaa aggcatttta aaataaataa aaaaaagatg gtttttacca     1500

tcttttttaa ctcccgaaag ggagttcttt cttttcttga tactatacgt aactatttcg     1560

atttgccctg aacctaatca aagctagata aattcagtat tagggcataa aaaaacttgc     1620

tttttcgggt ggaaatctgt ataatttaaa ttgcttagat aaaaattacc aattccatac     1680

gaaaggagca agttttacat aaggttaaag ccttatgtga attctcattt aattacatga     1740

ataataataa cacagaaagt gaagaattaa aagagcaaag tcaactattg cttgacaaat     1800

gcacaaaaaa gaaaaagaaa aatcctaaat ttagtagtta tatagaacca ttagtaagca     1860

agaaattatc tgaaagaata aaggaatgtg gtgacttttt gcagatgtta tctgatttaa     1920

accttgaaaa ttcgaaactg catagagcaa gtttttgtgg taacagattt tgtcctatgt     1980

gtagctggcg tattgcttgt aaggatagtt tggaaatatc tattctcatg gagcatttac     2040

gcaaagagga aagcaaagaa tttatctttt tgaccttaac aactccaaat gtgaaaggtg     2100

cggaccttga taattccata aaagcataca ataaagcatt taaaaagtta atggaacgca     2160

aagaggtcaa gagcatagta aaaggctaca taagaaagct agaagtaacc tataatttgg     2220

acaagagttc caaatcatat aatacttatc acccacattt ccatgtggta ctagcagtca     2280

atagaagtta ctttaaaaag caaaatctat atataaacca tcatagatgg cttagtttgt     2340

ggcaagagtc aactggtgat tattcgataa ctcaagttga tgtaagaaag gctaaaatta     2400

acgattataa agaggtttat gagcttgcta agtattcggc taaggattcc gactatttaa     2460

tcaatagaga agtgtttacg gtattctaca aatctttaaa gggtaaacag gtacttgtat     2520

ttagtggatt atttaaagac gctcataaaa tgtataagaa tggagagcta gatctgtata     2580

agaagttgga tactatcgaa tatgcttata tggtaagtta taactggctt aaaaagaagt     2640

atgatacttc aaatattaga gaattaactg aggaagaaaa gcagaaattc aataaaaatt     2700

taatcgaaga tgtggatatt gagtaggtgg gattatatct cacctttttt attgtctttt     2760

catgttgaaa ttttgacgct taatgcatga agtattgaca agtttaaaaa ttacggtttt     2820

taatccttag ttgattagca ggattatggc cggaatgctc cgtccagtcc tgttaaggaa     2880

ttaaaattcc ctaaaaccct tggctatgat ttatagcgag aatcgtcaat taaaaattta     2940

ataggtgcta tgaaagtcga ttaataatta attttaaaat gcaatatgaa acataattac     3000

aagaatttga cttttaatac aagaattgat atcatagtta cattaatacg gatccccggg     3060

taccgagctc gaattcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     3120

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     3180

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tggcgcctga     3240

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg tgcactctca     3300

gtacaatctg ctctgatgcc gcatagttaa gccagccccg acacccgcca acacccgctg     3360

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     3420

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg     3480

gcctcgtgat acgcctattt ttataggtta atgtcatgat aataatggtt tcttagacgt     3540

caggtggcac ttttcgggga aatgtgcgcg gaacccctat ttgtttattt ttctaaatac     3600

attcaaatat gtatccgctc atgagacaat aaccctgata aatgcttcaa taatattgaa     3660

aaaggaagag tatgagtatt caacatttcc gtgtcgccct tattcccttt tttgcggcat     3720

tttgccttcc tgtttttgct cacccagaaa cgctggtgaa agtaaaagat gctgaagatc     3780

agttgggtgc acgagtgggt tacatcgaac tggatctcaa cagcggtaag atccttgaga     3840

gttttcgccc cgaagaacgt tttccaatga tgagcacttt taaagttctg ctatgtggcg     3900

cggtattatc ccgtattgac gccgggcaag agcaactcgg tcgccgcata cactattctc     3960

agaatgactt ggttgagtac tcaccagtca cagaaaagca tcttacggat ggcatgacag     4020

taagagaatt atgcagtgct gccataacca tgagtgataa cactgcggcc aacttacttc     4080

tgacaacgat cggaggaccg aaggagctaa ccgctttttt gcacaacatg ggggatcatg     4140

taactcgcct tgatcgttgg gaaccggagc tgaatgaagc cataccaaac gacgagcgtg     4200

acaccacgat gcctgtagca atggcaacaa cgttgcgcaa actattaact ggcgaactac     4260

ttactctagc ttcccggcaa caattaatag actggatgga ggcggataaa gttgcaggac     4320

cacttctgcg ctcggccctt ccggctggct ggtttattgc tgataaatct ggagccggtg     4380

agcgtgggtc tcgcggtatc attgcagcac tggggccaga tggtaagccc tcccgtatcg     4440

tagttatcta cacgacgggg agtcaggcaa ctatggatga acgaaataga cagatcgctg     4500

agataggtgc ctcactgatt aagcattggt aactgtcaga ccaagtttac tcatatatac     4560

tttagattga tttaaaactt catttttaat ttaaaaggat ctaggtgaag atcctttttg     4620

ataatctcat gaccaaaatc ccttaacgtg agttttcgtt ccactgagcg tcagaccccg     4680

tagaaaagat caaaggatct tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc     4740

aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc     4800

tttttccgaa ggtaactggc ttcagcagag cgcagatacc aaatactgtt cttctagtgt     4860

agccgtagtt aggccaccac ttcaagaact ctgtagcacc gcctacatac ctcgctctgc     4920

taatcctgtt accagtggct gctgccagtg gcgataagtc gtgtcttacc gggttggact     4980

caagacgata gttaccggat aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac     5040

agcccagctt ggagcgaacg acctacaccg aactgagata cctacagcgt gagctatgag     5100

aaagcgccac gcttcccgaa gggagaaagg cggacaggta tccggtaagc ggcagggtcg     5160

gaacaggaga gcgcacgagg gagcttccag ggggaaacgc ctggtatctt tatagtcctg     5220

tcgggtttcg ccacctctga cttgagcgtc gatttttgtg atgctcgtca ggggggcgga     5280

gcctatggaa aaacgccagc aacgcggcct ttttacggtt cctggccttt tgctggcctt     5340

ttgctcacat gttctttcct gcgttatccc ctgattctgt ggataaccgt attaccgcct     5400

ttgagtgagc tgataccgct cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg     5460

aggaagcgga aga                                                        5473


<210>  120
<211>  9128
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMTL007S-E1

<400>  120
gatcgggccc cctgcagggt gtagtagcct gtgaaataag taaggaaaaa aaagaagtaa       60

gtgttatata tgatgattat tttgtagatg tagataggat aatagaatcc atagaaaata      120

taggttatac agttatataa aaattacttt aaaaattaat aaaaacatgg taaaatataa      180

atcgtataaa gttgtgtaat ttttaagctt gagctcataa caatttcaca caggaaacag      240

ctatgaccat gattacggat tcactggccg tcgttttaca acgtcgtgac tgggaaaacc      300

ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc tggcgtaata      360

gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat ggcgaatggc      420

gctaataaag atcttgtaca atctgtagga gaacctatgg gaacgaaacg aaagcgatgc      480

cgagaatctg aatttaccaa gacttaacac taactgggga taccctaaac aagaatgcct      540

aatagaaagg aggaaaaagg ctatagcact agagcttgaa aatcttgcaa gggtacggag      600

tactcgtagt agtctgagaa gggtaacgcc ctttacatgg caaaggggta cagttattgt      660

gtactaaaat taaaaattga ttagggagga aaacctcaaa atgaaaccaa caatggcaat      720

tttagaaaga atcagtaaaa attcacaaga aaatatagac gaagttttta caagacttta      780

tcgttatctt ttacgtccag atatttatta cgtggcgacg cgtgcgactc atagaattat      840

ttcctcccgt taaataatag ataactatta aaaatagaca atacttgctc ataagtaacg      900

gtacttaaat tgtttacttt ggcgtgtttc attgcttgat gaaactgatt tttagtaaac      960

agttgacgat attctcgatt gacccatttt gaaacaaagt acgtatatag cttccaatat     1020

ttatctggaa catctgtggt atggcgggta agttttatta agacactgtt tacttttggt     1080

ttaggatgaa agcattccgc tggcagctta agcaattgct gaatcgagac ttgagtgtgc     1140

aagagcaacc ctagtgttcg gtgaatatcc aaggtacgct tgtagaatcc ttcttcaaca     1200

atcagataga tgtcagacgc atggctttca aaaaccactt ttttaataat ttgtgtgctt     1260

aaatggtaag gaatactccc aacaatttta tacctctgtt tgttagggaa ttgaaactgt     1320

agaatatctt ggtgaattaa agtgacacga gtattcagtt ttaatttttc tgacgataag     1380

ttgaatagat gactgtctaa ttcaatagac gttacctgtt tacttatttt agccagtttc     1440

gtcgttaaat gccctttacc tgttccaatt tcgtaaacgg tatcggtttc ttttaaattc     1500

aattgtttta ttatttggtt gagtactttt tcactcgtta aaaagttttg agaatatttt     1560

atatttttgt tcataccagc accagaagca ccagcatctc ttgggttaat tgaggcctga     1620

gtataaggtg acttatactt gtaatctatc taaacgggga acctctctag tagacaatcc     1680

cgtgctaaat tgtaggactg ccctttaata aatacttcta tatttaaaga ggtatttatg     1740

aaaagcggaa tttatcagat taaaaatact ttctctagag aaaatttcgt ctggattagt     1800

tacttatcgt gtaaaatctg ataaatggaa ttggttctac ataaatgcct aacgactatc     1860

cctttgggga gtagggtcaa gtgactcgaa acgatagaca acttgcttta acaagttgga     1920

gatatagtct gctctgcatg gtgacatgca gctggatata attccggggt aagattaacg     1980

accttatctg aacataatgc catatgaatc cctcctaatt tatacgtttt ctctaacaac     2040

ttaattatac ccactattat tatttttatc aatataacgc gttgggaaat ggcaatgata     2100

gcgaaacaac gtaaaactct tgttgtatgc tttcattgtc atcgtcacgt gattcataaa     2160

cacaagtgaa tgtcgacagt gaatttttac gaacgaacaa taacagagcc gtatactccg     2220

agaggggtac gtacggttcc cgaagagggt ggtgcaaacc agtcacagta atgtgaacaa     2280

ggcggtacct ccctacttca ccatatcatt ttctgcagcc ccctagaaat aattttgttt     2340

aactttaaga aggagatata catatatggc tagatcgtcc attccgacag catcgccagt     2400

cactatggcg tgctgctagc gctatatgcg ttgatgcaat ttctatgcac tcgtagtagt     2460

ctgagaaggg taacgccctt tacatggcaa aggggtacag ttattgtgta ctaaaattaa     2520

aaattgatta gggaggaaaa cctcaaaatg aaaccaacaa tggcaatttt agaaagaatc     2580

agtaaaaatt cacaagaaaa tatagacgaa gtttttacaa gactttatcg ttatctttta     2640

cgtccagata tttattacgt ggcgtatcaa aatttatatt ccaataaagg agcttccaca     2700

aaaggaatat tagatgatac agcggatggc tttagtgaag aaaaaataaa aaagattatt     2760

caatctttaa aagacggaac ttactatcct caacctgtac gaagaatgta tattgcaaaa     2820

aagaattcta aaaagatgag acctttagga attccaactt tcacagataa attgatccaa     2880

gaagctgtga gaataattct tgaatctatc tatgaaccgg tattcgaaga tgtgtctcac     2940

ggttttagac ctcaacgaag ctgtcacaca gctttgaaaa caatcaaaag agagtttggc     3000

ggcgcaagat ggtttgtgga gggagatata aaaggctgct tcgataatat agaccacgtt     3060

acactcattg gactcatcaa tcttaaaatc aaagatatga aaatgagcca attgatttat     3120

aaatttctaa aagcaggtta tctggaaaac tggcagtatc acaaaactta cagcggaaca     3180

cctcaaggtg gaattctatc tcctcttttg gccaacatct atcttcatga attggataag     3240

tttgttttac aactcaaaat gaagtttgac cgagaaagtc cagaaagaat aacacctgaa     3300

tatcgggagc tccacaatga gataaaaaga atttctcacc gtctcaagaa gttggagggt     3360

gaagaaaaag ctaaagttct tttagaatat caagaaaaac gtaaaagatt acccacactc     3420

ccctgtacct cacagacaaa taaagtattg aaatacgtcc ggtatgcgga cgacttcatt     3480

atctctgtta aaggaagcaa agaggactgt caatggataa aagaacaatt aaaacttttt     3540

attcataaca agctaaaaat ggaattgagt gaagaaaaaa cactcatcac acatagcagt     3600

caacccgctc gttttctggg atatgatata cgagtaagga gatctggaac gataaaacga     3660

tctggtaaag tcaaaaagag aacactcaat gggagtgtag aactccttat tcctcttcaa     3720

gacaaaattc gtcaatttat ttttgacaag aaaatagcta tccaaaagaa agatagctca     3780

tggtttccag ttcacaggaa atatcttatt cgttcaacag acttagaaat catcacaatt     3840

tataattctg aactccgcgg gatttgtaat tactacggtc tagcaagtaa ttttaaccag     3900

ctcaattatt ttgcttatct tatggaatac agctgtctaa aaacgatagc ctccaaacat     3960

aagggaacac tttcaaaaac catttccatg tttaaagatg gaagtggttc gtgggggatc     4020

ccgtatgaga taaagcaagg taagcagcgc cgttattttg caaattttag tgaatgtaaa     4080

tccccttatc aatttacgga tgagataagt caagctcctg tattgtatgg ctatgcccgg     4140

aatactcttg aaaacaggtt aaaagctaaa tgttgtgaat tatgtgggac gtctgatgaa     4200

aatacttcct atgaaattca ccatgtcaat aaggtcaaaa atcttaaagg caaagaaaaa     4260

tgggaaatgg caatgatagc gaaacaacgt aaaactcttg ttgtatgctt tcattgtcat     4320

cgtcacgtga ttcataaaca caagtgaatg tcgagcaccc gttctcggag cactgtccga     4380

ccgctttggc cgccgcccag tcctgctcgc ttcgctactt ggagccacta tcgactacgc     4440

gatcatggcg accacacccg tcctgtggat cgccaagccg ccgatggtag tgtggggtct     4500

ccccatgcga gagtagggaa ctgccaggca tcaaataaaa cgaaaggctc agtcgaaaga     4560

ctgggccttt cgttttatct gttgtttgtc ggtgaacgct ctcctgagta ggacaaatcc     4620

gccgggagcg gatttgaacg ttgcgaagca acggcccgga gggtggcggg caggacgccc     4680

gccataaact gccaggcatc aaattaagca gaaggccatc ctgacggatg gcctttttgc     4740

gtttctacaa actcttcctg tcgtcatatc tacaagccat ccccccacag atacgggcgc     4800

gccgccatta tttttttgaa caattgacaa ttcatttctt attttttatt aagtgatagt     4860

caaaaggcat aacagtgctg aatagaaaga aatttacaga aaagaaaatt atagaattta     4920

gtatgattaa ttatactcat ttatgaatgt ttaattgaat acaaaaaaaa atacttgtta     4980

tgtattcaat tacgggttaa aatatagaca agttgaaaaa tttaataaaa aaataagtcc     5040

tcagctctta tatattaagc taccaactta gtatataagc caaaacttaa atgtgctacc     5100

aacacatcaa gccgttagag aactctatct atagcaatat ttcaaatgta ccgacataca     5160

agagaaacat taactatata tattcaattt atgagattat cttaacagat ataaatgtaa     5220

attgcaataa gtaagattta gaagtttata gcctttgtgt attggaagca gtacgcaaag     5280

gcttttttat ttgataaaaa ttagaagtat atttattttt tcataattaa tttatgaaaa     5340

tgaaaggggg tgagcaaagt gacagaggaa agcagtatct tatcaaataa caaggtatta     5400

gcaatatcat tattgacttt agcagtaaac attatgactt ttatagtgct tgtagctaag     5460

tagtacgaaa gggggagctt taaaaagctc cttggaatac atagaattca taaattaatt     5520

tatgaaaaga agggcgtata tgaaaacttg taaaaattgc aaagagttta ttaaagatac     5580

tgaaatatgc aaaatacatt cgttgatgat tcatgataaa acagtagcaa cctattgcag     5640

taaatacaat gagtcaagat gtttacataa agggaaagtc caatgtatta attgttcaaa     5700

gatgaaccga tatggatggt gtgccataaa aatgagatgt tttacagagg aagaacagaa     5760

aaaagaacgt acatgcatta aatattatgc aaggagcttt aaaaaagctc atgtaaagaa     5820

gagtaaaaag aaaaaataat ttatttatta atttaatatt gagagtgccg acacagtatg     5880

cactaaaaaa tatatctgtg gtgtagtgag ccgatacaaa aggatagtca ctcgcatttt     5940

cataatacat cttatgttat gattatgtgt cggtgggact tcacgacgaa aacccacaat     6000

aaaaaaagag ttcggggtag ggttaagcat agttgaggca actaaacaat caagctagga     6060

tatgcagtag cagaccgtaa ggtcgttgtt taggtgtgtt gtaatacata cgctattaag     6120

atgtaaaaat acggatacca atgaagggaa aagtataatt tttggatgta gtttgtttgt     6180

tcatctatgg gcaaactacg tccaaagccg tttccaaatc tgctaaaaag tatatccttt     6240

ctaaaatcaa agtcaagtat gaaatcataa ataaagttta attttgaagt tattatgata     6300

ttatgttttt ctattaaaat aaattaagta tatagaatag tttaataata gtatatactt     6360

aatgtgataa gtgtctgaca gtgtcacaga aaggatgatt gttatggatt ataagcggcc     6420

ggcccaatga ataggtttac acttacttta gttttatgga aatgaaagat catatcatat     6480

ataatctaga ataaaattaa ctaaaataat tattatctag ataaaaaatt tagaagccaa     6540

tgaaatctat aaataaacta aattaagttt atttaattaa caactatgga tataaaatag     6600

gtactaatca aaatagtgag gaggatatat ttgaatacat acgaacaaat taataaagtg     6660

aaaaaaatac ttcggaaaca tttaaaaaat aaccttattg gtacttacat gtttggatca     6720

ggagttgaga gtggactaaa accaaatagt gatcttgact ttttagtcgt cgtatctgaa     6780

ccattgacag atcaaagtaa agaaatactt atacaaaaaa ttagacctat ttcaaagaaa     6840

ataggagata aaagcaactt acgatatatt gaattaacaa ttattattca gcaagaaatg     6900

gtaccgtgga atcatcctcc caaacaagaa tttatttatg gagaatggtt acaagagctt     6960

tatgaacaag gatacattcc tcagaaggaa ttaaattcag atttaaccat aatgctttac     7020

caagcaaaac gaaaaaataa aagaatatac ggaaattatg acttagagga attactacct     7080

gatattccat tttctgatgt gagaagagcc attatggatt cgtcagagga attaatagat     7140

aattatcagg atgatgaaac caactctata ttaactttat gccgtatgat tttaactatg     7200

gacacgggta aaatcatacc aaaagatatt gcgggaaatg cagtggctga atcttctcca     7260

ttagaacata gggagagaat tttgttagca gttcgtagtt atcttggaga gaatattgaa     7320

tggactaatg aaaatgtaaa tttaactata aactatttaa ataacagatt aaaaaaatta     7380

taaaaaaatt gaaaaaatgg tggaaacact tttttcaatt tttttgtttt attatttaat     7440

atttgggaaa tattcattct aattggtaat cagattttag aagtttaaac tcctttttga     7500

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     7560

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     7620

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     7680

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgttc ttctagtgta     7740

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     7800

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     7860

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     7920

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     7980

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     8040

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     8100

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     8160

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     8220

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     8280

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     8340

ggaagcggaa gagcgcccaa tacgcagggc cccctgcttc ggggtcatta tagcgatttt     8400

ttcggtatat ccatcctttt tcgcacgata tacaggattt tgccaaaggg ttcgtgtaga     8460

ctttccttgg tgtatccaac ggcgtcagcc gggcaggata ggtgaagtag gcccacccgc     8520

gagcgggtgt tccttcttca ctgtccctta ttcgcacctg gcggtgctca acgggaatcc     8580

tgctctgcga ggctggccgg ctaccgccgg cgtaacagat gagggcaagc ggatggctga     8640

tgaaaccaag ccaaccagga agggcagccc acctatcaag gtgtactgcc ttccagacga     8700

acgaagagcg attgaggaaa aggcggcggc ggccggcatg agcctgtcgg cctacctgct     8760

ggccgtcggc cagggctaca aaatcacggg cgtcgtggac tatgagcacg tccgcgagct     8820

ggcccgcatc aatggcgacc tgggccgcct gggcggcctg ctgaaactct ggctcaccga     8880

cgacccgcgc acggcgcggt tcggtgatgc cacgatcctc gccctgctgg cgaagatcga     8940

agagaagcag gacgagcttg gcaaggtcat gatgggcgtg gtccgcccga gggcagagcc     9000

atgacttttt tagccgctaa aacggccggg gggtgcgcgt gattgccaag cacgtcccca     9060

tgcgctccat caagaagagc gacttcgcgg agctggtgaa gtacatcacc gacgagcaag     9120

gcaagacc                                                              9128


<210>  121
<211>  5002
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pEC751S

<400>  121
atcaaaaaaa tttccaataa tcccactcta agccacaaac acgccctata aaatcccgct       60

ttaatcccac tttgagacac atgtaatatt actttacgcc ctagtatagt gataattttt      120

tacattcaat gccacgcaaa aaaataaagg ggcactataa taaaagttcc ttcggaacta      180

actaaagtaa aaaattatct ttacaacctc cccaaaaaaa agaacaggta caaagtaccc      240

tataatacaa gcgtaaaaaa aatgagggta aaaataaaaa aataaaaaaa taaaaaaata      300

aaaaaataaa aaaataaaaa aataaaaaaa tataaaaata aaaaaatata aaaataaaaa      360

aatataaaaa taaaaaaata aaaaaatata aaaataaaaa aataaaaaaa tataaaaata      420

ttttttattt aaagtttgaa aaaaattttt ttatattata taatctttga agaaaagaat      480

ataaaaaatg agcctttata aaagcccatt ttttttcata tacgtaatat gacgttctaa      540

tgtttttatt ggtacttcta acattagagt aatttcttta tttttaaagc ctttttcttt      600

aagggctttt attttttttc ttaatacatt taattcctct ttttttgttg cttttccttt      660

agcttttaat tgctcttgat aatttttttt acctctaata ttttctcttc tcttatattc      720

ctttttagaa attattattg tcatatattt ttgttcttct tctgtaattt ctaataactc      780

tataagagtt tcattcttat acttatattg cttattttta tctaaataac atctttcagc      840

acttctagtt gctcttataa cttctctttc acttaaatgt tgtctaaaca tactattaag      900

ttctaaaaca tcatttaatg ccttctcaat gtcttctgta aagctacaaa gataatatct      960

atataaaaat aatataagct ctctgtgtcc ttttaaatca tattctctta gttcacaaag     1020

ttttattatg tcttgtattc ttccataata taaacttctt tctctataaa tataatttat     1080

tttgcttggt ctaccctttt tcctttcata tggttttaat tcaggtaaaa atccattttg     1140

tatttctctt aagtcataaa tatattcgta ctcatctaat atattgacta ctgtttttga     1200

tttagagttt atacttcctg gaactcttaa tattctcgtt gcatctaagg cttgtctatc     1260

tgctccaaag tattttaatt gattatataa atattcttga accgctttcc ataatggtaa     1320

tgctttacta ggtactgcat ttattatcca tattaaatac attcctcttc cactatctat     1380

tacatagttt ggtataggaa tactttgatt aaaataattc ttttctaagt ccattaatac     1440

ctggtcttta gttttgccag ttttataata atccaagtct ataaacagtg tatttaactc     1500

ttttatattt tctaatcgcc tacacggctt ataaaaggta tttagagtta tatagatatt     1560

ttcatcactc atatctaaat cttttaattc agcgtattta tagtgccatt ggctatatcc     1620

ttttttatct ataacgctcc tggttatcca ccctttactt ctactatgaa tattatctat     1680

atagttcttt ttattcagct ttaatgcgtt tctcacttat tcacctcccc ttctgtaaaa     1740

ctaagaaaat tatatcatat tttcaataat tattaactat tcttaaactc ttaataaaaa     1800

atagagtaag tccccaattg aaacttaatc tattttttat gttttaattt attattttta     1860

ttaaaatatt ttaaactaaa ttaaatgatt ctttttaatt ttttactatt tcattccata     1920

atatattact ataattattt acaaataata tttcttcatt tgtaatattt agatgattta     1980

ctaattttag tttttatata ttaaataatt aatgtataat ttatataaaa aatcaaagga     2040

gcttataaat tatgattatt tccaaagata ctaaagattt aatttttttc aattttaaca     2100

atactttttg taatattatg tttaaattta attgtatttt tttcatataa taaagccgtt     2160

gaagtaaacc aatccatttt ccttatgatg ttattattaa atttaagttt tataataata     2220

tctttattat atttattgtt tttaaaaaaa ctagtgaaat ttctagtgaa atttccggct     2280

ttattaaact tatttttagg aattttattt tcattttcat ctttacagga tttgattata     2340

tctttaaata tgttttatca aatattatct ttttctaaat ttatatatat ttttattata     2400

tttattatta tatatatttt atttttaagt ttctttctaa cagctattaa aaagaaactt     2460

aaaaataaaa acacgtactc taaaccaata aataaaacta tttttattat tgctgccttg     2520

attggaatag tttttagtaa aattaatttc aatattccac aatattatat tataagctag     2580

cacgcctcga gatctccatg gacgcgtgac gtcgactcta gaggatcccc gggtaccgag     2640

ctcgaattcg taatcatggt catagctgtt tcctgtgtga aattgttatc cgctcacaat     2700

tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct aatgagtgag     2760

ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa acctgtcgtg     2820

ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta ttgggcgctc     2880

ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc gagcggtatc     2940

agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg caggaaagaa     3000

catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt tgctggcgtt     3060

tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa gtcagaggtg     3120

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct ccctcgtgcg     3180

ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc cttcgggaag     3240

cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg tcgttcgctc     3300

caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct tatccggtaa     3360

ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag cagccactgg     3420

taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga agtggtggcc     3480

taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga agccagttac     3540

cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg gtagcggtgg     3600

tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag aagatccttt     3660

gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag ggattttggt     3720

catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat gaagttttaa     3780

atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaaagct agcttaatac     3840

tagtatatac ttaatgtgat aagtgtctga cagctgaccg gtctaaagag gtcccaatga     3900

ataggtttac acttacttta gttttatgga aatgaaagat catatcatat ataatctaga     3960

ataaaattaa ctaaaataat tattatctag ataaaaaatt tagaagccaa tgaaatctat     4020

aaataaacta aattaagttt atttaattaa caactatgga tataaaatag gtactaatca     4080

aaatagtgag gaggatatat ttgaatacat acgaacaaat taataaagtg aaaaaaatac     4140

ttcggaaaca tttaaaaaat aaccttattg gtacttacat gtttggatca ggagttgaga     4200

gtggactaaa accaaatagt gatcttgact ttttagtcgt cgtatctgaa ccattgacag     4260

atcaaagtaa agaaatactt atacaaaaaa ttagacctat ttcaaagaaa ataggagata     4320

aaagcaactt acgatatatt gaattaacaa ttattattca gcaagaaatg gtaccgtgga     4380

atcatcctcc caaacaagaa tttatttatg gagaatggtt acaagagctt tatgaacaag     4440

gatacattcc tcagaaggaa ttaaattcag atttaaccat aatgctttac caagcaaaac     4500

gaaaaaataa aagaatatac ggaaattatg acttagagga attactacct gatattccat     4560

tttctgatgt gagaagagcc attatggatt cgtcagagga attaatagat aattatcagg     4620

atgatgaaac caactctata ttaactttat gccgtatgat tttaactatg gacacgggta     4680

aaatcatacc aaaagatatt gcgggaaatg cagtggctga atcttctcca ttagaacata     4740

gggagagaat tttgttagca gttcgtagtt atcttggaga gaatattgaa tggactaatg     4800

aaaatgtaaa tttaactata aactatttaa ataacagatt aaaaaaatta taaaaaaatt     4860

gaaaaaatgg tggaaacact tttttcaatt tttttgtttt attatttaat atttgggaaa     4920

tattcattct aattggtaat cagattttag aagttgttaa cttcaggttt gtctgtaact     4980

aaaaactagt atttaaccta gg                                              5002


<210>  122
<211>  3907
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFW01

<400>  122
tcgagatctc catggacgcg tgacgtcgac tctagaggat ccccgggtac cgagctcgaa       60

ttcgtaatca tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca      120

caacatacga gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact      180

cacattaatt gcgttgcgct cactgcccgc tttccagtcg ggaaacctgt cgtgccagct      240

gcattaatga atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc      300

ttcctcgctc actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca      360

ctcaaaggcg gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg      420

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca      480

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa      540

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc      600

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc      660

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct      720

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg      780

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag      840

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta      900

cggctacact agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg      960

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     1020

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     1080

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     1140

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     1200

ctaaagtata tatgagtaaa cttggtctga cagttaccag gtccactgcc gggcctcttg     1260

cgggatcaaa agaaaaacga aatgatacac caatcagtgc aaaaaaagat ataatgggag     1320

ataagacggt tcgtgttcgt gctgacttgc accatatcat aaaaatcgaa acagcaaaga     1380

atggcggaaa cgtaaaagaa gttatggaaa taagacttag aagcaaactt aagagtgtgt     1440

tgatagtgca gtatcttaaa attttgtata ataggaattg aagttaaatt agatgctaaa     1500

aatttgtaat taagaaggag tgattacatg aacaaaaata taaaatattc tcaaaacttt     1560

ttaacgagtg aaaaagtact caaccaaata ataaaacaat tgaatttaaa agaaaccgat     1620

accgtttacg aaattggaac aggtaaaggg catttaacga cgaaactggc taaaataagt     1680

aaacaggtaa cgtctattga attagacagt catctattca acttatcgtc agaaaaatta     1740

aaactgaata ctcgtgtcac tttaattcac caagatattc tacagtttca attccctaac     1800

aaacagaggt ataaaattgt tgggagtatt ccttaccatt taagcacaca aattattaaa     1860

aaagtggttt ttgaaagcca tgcgtctgac atctatctga ttgttgaaga aggattctac     1920

aagcgtacct tggatattca ccgaacacta gggttgctct tgcacactca agtctcgatt     1980

cagcaattgc ttaagctgcc agcggaatgc tttcatccta aaccaaaagt aaacagtgtc     2040

ttaataaaac ttacccgcca taccacagat gttccagata aatattggaa gctatatacg     2100

tactttgttt caaaatgggt caatcgagaa tatcgtcaac tgtttactaa aaatcagttt     2160

catcaagcaa tgaaacacgc caaagtaaac aatttaagta ccgttactta tgagcaagta     2220

ttgtctattt ttaatagtta tctattattt aacgggagga aataattcta tgagtcccta     2280

ggcaggcctc cgccattatt tttttgaaca attgacaatt catttcttat tttttattaa     2340

gtgatagtca aaaggcataa cagtgctgaa tagaaagaaa tttacagaaa agaaaattat     2400

agaatttagt atgattaatt atactcattt atgaatgttt aattgaatac aaaaaaaaat     2460

acttgttatg tattcaatta cgggttaaaa tatagacaag ttgaaaaatt taataaaaaa     2520

ataagtcctc agctcttata tattaagcta ccaacttagt atataagcca aaacttaaat     2580

gtgctaccaa cacatcaagc cgttagagaa ctctatctat agcaatattt caaatgtacc     2640

gacatacaag agaaacatta actatatata ttcaatttat gagattatct taacagatat     2700

aaatgtaaat tgcaataagt aagatttaga agtttatagc ctttgtgtat tggaagcagt     2760

acgcaaaggc ttttttattt gataaaaatt agaagtatat ttattttttc ataattaatt     2820

tatgaaaatg aaagggggtg agcaaagtga cagaggaaag cagtatctta tcaaataaca     2880

aggtattagc aatatcatta ttgactttag cagtaaacat tatgactttt atagtgcttg     2940

tagctaagta gtacgaaagg gggagcttta aaaagctcct tggaatacat agaattcata     3000

aattaattta tgaaaagaag ggcgtatatg aaaacttgta aaaattgcaa agagtttatt     3060

aaagatactg aaatatgcaa aatacattcg ttgatgattc atgataaaac agtagcaacc     3120

tattgcagta aatacaatga gtcaagatgt ttacataaag ggaaagtcca atgtattaat     3180

tgttcaaaga tgaaccgata tggatggtgt gccataaaaa tgagatgttt tacagaggaa     3240

gaacagaaaa aagaacgtac atgcattaaa tattatgcaa ggagctttaa aaaagctcat     3300

gtaaagaaga gtaaaaagaa aaaataattt atttattaat ttaatattga gagtgccgac     3360

acagtatgca ctaaaaaata tatctgtggt gtagtgagcc gatacaaaag gatagtcact     3420

cgcattttca taatacatct tatgttatga ttatgtgtcg gtgggacttc acgacgaaaa     3480

cccacaataa aaaaagagtt cggggtaggg ttaagcatag ttgaggcaac taaacaatca     3540

agctaggata tgcagtagca gaccgtaagg tcgttgttta ggtgtgttgt aatacatacg     3600

ctattaagat gtaaaaatac ggataccaat gaagggaaaa gtataatttt tggatgtagt     3660

ttgtttgttc atctatgggc aaactacgtc caaagccgtt tccaaatctg ctaaaaagta     3720

tatcctttct aaaatcaaag tcaagtatga aatcataaat aaagtttaat tttgaagtta     3780

ttatgatatt atgtttttct attaaaataa attaagtata tagaatagtt taataatagt     3840

atatacttaa tgtgataagt gtctgacagt gtcacagaaa ggatgattgt tatggattat     3900

aagcggc                                                               3907


<210>  123
<211>  6525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNF3S

<400>  123
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca       60

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct      120

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat      180

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcttgc      240

atgcctgcag gtcgaccacg ataaaacaag gttttaagga taagaaaagt catgagattt      300

atagtaaatc ttgtgacttt ttttattgaa tagtagagag agttcggaag tataacacgc      360

tatattcttg atatttttag aatagcaagc attggatttg tcctgacact ttcccaaaaa      420

ttaaggagtt attccttaaa ccaaaaagat taatgtggga acaaatttag tgtatccatt      480

tttgaagggc gcacttatac accaccaaaa tggtgtgtgc gaaatcttta aaaaagattt      540

atcaaaaagc ttttttaaag ctgggacatt tagaaaatca ataatgtttt ttgcccaata      600

cgctagtctt aaaatctgca aggttgataa ctatttagtc ccaggtatta gaatggggca      660

tatatataca aagtatatat atgcgtaaat atatgtggga ctgtgggaac aaaattgcgt      720

gctaaaattg tattgaaaag gtaatgaaaa ggtcatgctt tggtattgct aacgtataga      780

aaaggtaatg aaaagctcat ggttctataa aaaagatgta cccacgaaaa taataggctt      840

tgcctatttc cccatgtaat atgggggcag ttttctctta tgctctttct taacatattg      900

aataaataca aaatgcagct ttgtgggaat aaaaatattt ttgtttttat tcttatagtt      960

agacaaaatt ttaatctttt ttgtgctata acaagattaa aatttgtggg aacattaaga     1020

aatattgttg tcacaaataa aaaggagagt gggaacaatt gctataaaaa acgcagaaat     1080

taagattaga gttacaaaag agcaaaaaga attatttaag aaaattgcaa aagctgaaaa     1140

tatgagtatg agtgaattta ttattgtgac cacagaatat ttagccagaa aaaaagatga     1200

aaatatgaaa tcaaaagaca tgatcgagag aagagctgcg aagactgaag aaaaaattat     1260

gaagctaaaa aagaaactaa ataaaaacag gtaatataga ttacagtttt aagcttgttt     1320

tccctataga ctagagtaaa tatataaata tacctgtcaa gggcttataa gcccctttag     1380

ggggtgcgta gcacccttga caggtatatt tatatatttt agggtgccat taagggaaac     1440

aagctttaaa atgcctttaa aggcatttta aaataaataa aaaaaagatg gtttttacca     1500

tcttttttaa ctcccgaaag ggagttcttt cttttcttga tactatacgt aactatttcg     1560

atttgccctg aacctaatca aagctagata aattcagtat tagggcataa aaaaacttgc     1620

tttttcgggt ggaaatctgt ataatttaaa ttgcttagat aaaaattacc aattccatac     1680

gaaaggagca agttttacat aaggttaaag ccttatgtga attctcattt aattacatga     1740

ataataataa cacagaaagt gaagaattaa aagagcaaag tcaactattg cttgacaaat     1800

gcacaaaaaa gaaaaagaaa aatcctaaat ttagtagtta tatagaacca ttagtaagca     1860

agaaattatc tgaaagaata aaggaatgtg gtgacttttt gcagatgtta tctgatttaa     1920

accttgaaaa ttcgaaactg catagagcaa gtttttgtgg taacagattt tgtcctatgt     1980

gtagctggcg tattgcttgt aaggatagtt tggaaatatc tattctcatg gagcatttac     2040

gcaaagagga aagcaaagaa tttatctttt tgaccttaac aactccaaat gtgaaaggtg     2100

cggaccttga taattccata aaagcataca ataaagcatt taaaaagtta atggaacgca     2160

aagaggtcaa gagcatagta aaaggctaca taagaaagct agaagtaacc tataatttgg     2220

acaagagttc caaatcatat aatacttatc acccacattt ccatgtggta ctagcagtca     2280

atagaagtta ctttaaaaag caaaatctat atataaacca tcatagatgg cttagtttgt     2340

ggcaagagtc aactggtgat tattcgataa ctcaagttga tgtaagaaag gctaaaatta     2400

acgattataa agaggtttat gagcttgcta agtattcggc taaggattcc gactatttaa     2460

tcaatagaga agtgtttacg gtattctaca aatctttaaa gggtaaacag gtacttgtat     2520

ttagtggatt atttaaagac gctcataaaa tgtataagaa tggagagcta gatctgtata     2580

agaagttgga tactatcgaa tatgcttata tggtaagtta taactggctt aaaaagaagt     2640

atgatacttc aaatattaga gaattaactg aggaagaaaa gcagaaattc aataaaaatt     2700

taatcgaaga tgtggatatt gagtaggtgg gattatatct cacctttttt attgtctttt     2760

catgttgaaa ttttgacgct taatgcatga agtattgaca agtttaaaaa ttacggtttt     2820

taatccttag ttgattagca ggattatggc cggaatgctc cgtccagtcc tgttaaggaa     2880

ttaaaattcc ctaaaaccct tggctatgat ttatagcgag aatcgtcaat taaaaattta     2940

ataggtgcta tgaaagtcga ttaataatta attttaaaat gcaatatgaa acataattac     3000

aagaatttga cttttaatac aagaattgat atcatagtta cattaatacg gatcccaatg     3060

aataggttta cacttacttt agttttatgg aaatgaaaga tcatatcata tataatctag     3120

aataaaatta actaaaataa ttattatcta gataaaaaat ttagaagcca atgaaatcta     3180

taaataaact aaattaagtt tatttaatta acaactatgg atataaaata ggtactaatc     3240

aaaatagtga ggaggatata tttgaataca tacgaacaaa ttaataaagt gaaaaaaata     3300

cttcggaaac atttaaaaaa taaccttatt ggtacttaca tgtttggatc aggagttgag     3360

agtggactaa aaccaaatag tgatcttgac tttttagtcg tcgtatctga accattgaca     3420

gatcaaagta aagaaatact tatacaaaaa attagaccta tttcaaagaa aataggagat     3480

aaaagcaact tacgatatat tgaattaaca attattattc agcaagaaat ggtaccgtgg     3540

aatcatcctc ccaaacaaga atttatttat ggagaatggt tacaagagct ttatgaacaa     3600

ggatacattc ctcagaagga attaaattca gatttaacca taatgcttta ccaagcaaaa     3660

cgaaaaaata aaagaatata cggaaattat gacttagagg aattactacc tgatattcca     3720

ttttctgatg tgagaagagc cattatggat tcgtcagagg aattaataga taattatcag     3780

gatgatgaaa ccaactctat attaacttta tgccgtatga ttttaactat ggacacgggt     3840

aaaatcatac caaaagatat tgcgggaaat gcagtggctg aatcttctcc attagaacat     3900

agggagagaa ttttgttagc agttcgtagt tatcttggag agaatattga atggactaat     3960

gaaaatgtaa atttaactat aaactattta aataacagat taaaaaaatt ataaaaaaat     4020

tgaaaaaatg gtggaaacac ttttttcaat ttttttgttt tattatttaa tatttgggaa     4080

atattcattc taattggtaa tcagatttta gaagttgagc tcgaattcac tggccgtcgt     4140

tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca     4200

tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca     4260

gttgcgcagc ctgaatggcg aatggcgcct gatgcggtat tttctcctta cgcatctgtg     4320

cggtatttca caccgcatat ggtgcactct cagtacaatc tgctctgatg ccgcatagtt     4380

aagccagccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc     4440

ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc     4500

accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg atacgcctat ttttataggt     4560

taatgtcatg ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg     4620

cggaacccct atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca     4680

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt     4740

ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga     4800

aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga     4860

actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat     4920

gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     4980

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt     5040

cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac     5100

catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct     5160

aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga     5220

gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     5280

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat     5340

agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg     5400

ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc     5460

actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc     5520

aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg     5580

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta     5640

atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg     5700

tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga     5760

tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt     5820

ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag     5880

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagaa     5940

ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag     6000

tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca     6060

gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac     6120

cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     6180

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc     6240

agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg     6300

tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc     6360

ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc     6420

ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     6480

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaaga                     6525


<210>  124
<211>  6554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNF3E

<400>  124
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca       60

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct      120

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat      180

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcttgc      240

atgcctgcag gtcgaccacg ataaaacaag gttttaagga taagaaaagt catgagattt      300

atagtaaatc ttgtgacttt ttttattgaa tagtagagag agttcggaag tataacacgc      360

tatattcttg atatttttag aatagcaagc attggatttg tcctgacact ttcccaaaaa      420

ttaaggagtt attccttaaa ccaaaaagat taatgtggga acaaatttag tgtatccatt      480

tttgaagggc gcacttatac accaccaaaa tggtgtgtgc gaaatcttta aaaaagattt      540

atcaaaaagc ttttttaaag ctgggacatt tagaaaatca ataatgtttt ttgcccaata      600

cgctagtctt aaaatctgca aggttgataa ctatttagtc ccaggtatta gaatggggca      660

tatatataca aagtatatat atgcgtaaat atatgtggga ctgtgggaac aaaattgcgt      720

gctaaaattg tattgaaaag gtaatgaaaa ggtcatgctt tggtattgct aacgtataga      780

aaaggtaatg aaaagctcat ggttctataa aaaagatgta cccacgaaaa taataggctt      840

tgcctatttc cccatgtaat atgggggcag ttttctctta tgctctttct taacatattg      900

aataaataca aaatgcagct ttgtgggaat aaaaatattt ttgtttttat tcttatagtt      960

agacaaaatt ttaatctttt ttgtgctata acaagattaa aatttgtggg aacattaaga     1020

aatattgttg tcacaaataa aaaggagagt gggaacaatt gctataaaaa acgcagaaat     1080

taagattaga gttacaaaag agcaaaaaga attatttaag aaaattgcaa aagctgaaaa     1140

tatgagtatg agtgaattta ttattgtgac cacagaatat ttagccagaa aaaaagatga     1200

aaatatgaaa tcaaaagaca tgatcgagag aagagctgcg aagactgaag aaaaaattat     1260

gaagctaaaa aagaaactaa ataaaaacag gtaatataga ttacagtttt aagcttgttt     1320

tccctataga ctagagtaaa tatataaata tacctgtcaa gggcttataa gcccctttag     1380

ggggtgcgta gcacccttga caggtatatt tatatatttt agggtgccat taagggaaac     1440

aagctttaaa atgcctttaa aggcatttta aaataaataa aaaaaagatg gtttttacca     1500

tcttttttaa ctcccgaaag ggagttcttt cttttcttga tactatacgt aactatttcg     1560

atttgccctg aacctaatca aagctagata aattcagtat tagggcataa aaaaacttgc     1620

tttttcgggt ggaaatctgt ataatttaaa ttgcttagat aaaaattacc aattccatac     1680

gaaaggagca agttttacat aaggttaaag ccttatgtga attctcattt aattacatga     1740

ataataataa cacagaaagt gaagaattaa aagagcaaag tcaactattg cttgacaaat     1800

gcacaaaaaa gaaaaagaaa aatcctaaat ttagtagtta tatagaacca ttagtaagca     1860

agaaattatc tgaaagaata aaggaatgtg gtgacttttt gcagatgtta tctgatttaa     1920

accttgaaaa ttcgaaactg catagagcaa gtttttgtgg taacagattt tgtcctatgt     1980

gtagctggcg tattgcttgt aaggatagtt tggaaatatc tattctcatg gagcatttac     2040

gcaaagagga aagcaaagaa tttatctttt tgaccttaac aactccaaat gtgaaaggtg     2100

cggaccttga taattccata aaagcataca ataaagcatt taaaaagtta atggaacgca     2160

aagaggtcaa gagcatagta aaaggctaca taagaaagct agaagtaacc tataatttgg     2220

acaagagttc caaatcatat aatacttatc acccacattt ccatgtggta ctagcagtca     2280

atagaagtta ctttaaaaag caaaatctat atataaacca tcatagatgg cttagtttgt     2340

ggcaagagtc aactggtgat tattcgataa ctcaagttga tgtaagaaag gctaaaatta     2400

acgattataa agaggtttat gagcttgcta agtattcggc taaggattcc gactatttaa     2460

tcaatagaga agtgtttacg gtattctaca aatctttaaa gggtaaacag gtacttgtat     2520

ttagtggatt atttaaagac gctcataaaa tgtataagaa tggagagcta gatctgtata     2580

agaagttgga tactatcgaa tatgcttata tggtaagtta taactggctt aaaaagaagt     2640

atgatacttc aaatattaga gaattaactg aggaagaaaa gcagaaattc aataaaaatt     2700

taatcgaaga tgtggatatt gagtaggtgg gattatatct cacctttttt attgtctttt     2760

catgttgaaa ttttgacgct taatgcatga agtattgaca agtttaaaaa ttacggtttt     2820

taatccttag ttgattagca ggattatggc cggaatgctc cgtccagtcc tgttaaggaa     2880

ttaaaattcc ctaaaaccct tggctatgat ttatagcgag aatcgtcaat taaaaattta     2940

ataggtgcta tgaaagtcga ttaataatta attttaaaat gcaatatgaa acataattac     3000

aagaatttga cttttaatac aagaattgat atcatagtta cattaatacg gatccgtctg     3060

acagttacca ggtccactgc cgggcctctt gcgggatcaa aagaaaaacg aaatgataca     3120

ccaatcagtg caaaaaaaga tataatggga gataagacgg ttcgtgttcg tgctgacttg     3180

caccatatca taaaaatcga aacagcaaag aatggcggaa acgtaaaaga agttatggaa     3240

ataagactta gaagcaaact taagagtgtg ttgatagtgc agtatcttaa aattttgtat     3300

aataggaatt gaagttaaat tagatgctaa aaatttgtaa ttaagaagga gtgattacat     3360

gaacaaaaat ataaaatatt ctcaaaactt tttaacgagt gaaaaagtac tcaaccaaat     3420

aataaaacaa ttgaatttaa aagaaaccga taccgtttac gaaattggaa caggtaaagg     3480

gcatttaacg acgaaactgg ctaaaataag taaacaggta acgtctattg aattagacag     3540

tcatctattc aacttatcgt cagaaaaatt aaaactgaat actcgtgtca ctttaattca     3600

ccaagatatt ctacagtttc aattccctaa caaacagagg tataaaattg ttgggagtat     3660

tccttaccat ttaagcacac aaattattaa aaaagtggtt tttgaaagcc atgcgtctga     3720

catctatctg attgttgaag aaggattcta caagcgtacc ttggatattc accgaacact     3780

agggttgctc ttgcacactc aagtctcgat tcagcaattg cttaagctgc cagcggaatg     3840

ctttcatcct aaaccaaaag taaacagtgt cttaataaaa cttacccgcc ataccacaga     3900

tgttccagat aaatattgga agctatatac gtactttgtt tcaaaatggg tcaatcgaga     3960

atatcgtcaa ctgtttacta aaaatcagtt tcatcaagca atgaaacacg ccaaagtaaa     4020

caatttaagt accgttactt atgagcaagt attgtctatt tttaatagtt atctattatt     4080

taacgggagg aaataattct atgagtccct aggcaggcct ccgccattat ttttttgaac     4140

aattggagct cgaattcact ggccgtcgtt ttacaacgtc gtgactggga aaaccctggc     4200

gttacccaac ttaatcgcct tgcagcacat ccccctttcg ccagctggcg taatagcgaa     4260

gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc tgaatggcga atggcgcctg     4320

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     4380

agtacaatct gctctgatgc cgcatagtta agccagcccc gacacccgcc aacacccgct     4440

gacgcgccct gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc     4500

tccgggagct gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag     4560

ggcctcgtga tacgcctatt tttataggtt aatgtcatga taataatggt ttcttagacg     4620

tcaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     4680

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     4740

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     4800

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     4860

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     4920

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     4980

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     5040

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     5100

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     5160

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     5220

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     5280

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     5340

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     5400

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     5460

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     5520

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     5580

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     5640

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     5700

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     5760

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     5820

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     5880

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt tcttctagtg     5940

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     6000

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     6060

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     6120

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     6180

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     6240

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     6300

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     6360

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     6420

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     6480

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     6540

gaggaagcgg aaga                                                       6554


<210>  125
<211>  6271
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pNF3C

<400>  125
gcgcccaata cgcaaaccgc ctctccccgc gcgttggccg attcattaat gcagctggca       60

cgacaggttt cccgactgga aagcgggcag tgagcgcaac gcaattaatg tgagttagct      120

cactcattag gcaccccagg ctttacactt tatgcttccg gctcgtatgt tgtgtggaat      180

tgtgagcgga taacaatttc acacaggaaa cagctatgac catgattacg ccaagcttgc      240

atgcctgcag gtcgaccacg ataaaacaag gttttaagga taagaaaagt catgagattt      300

atagtaaatc ttgtgacttt ttttattgaa tagtagagag agttcggaag tataacacgc      360

tatattcttg atatttttag aatagcaagc attggatttg tcctgacact ttcccaaaaa      420

ttaaggagtt attccttaaa ccaaaaagat taatgtggga acaaatttag tgtatccatt      480

tttgaagggc gcacttatac accaccaaaa tggtgtgtgc gaaatcttta aaaaagattt      540

atcaaaaagc ttttttaaag ctgggacatt tagaaaatca ataatgtttt ttgcccaata      600

cgctagtctt aaaatctgca aggttgataa ctatttagtc ccaggtatta gaatggggca      660

tatatataca aagtatatat atgcgtaaat atatgtggga ctgtgggaac aaaattgcgt      720

gctaaaattg tattgaaaag gtaatgaaaa ggtcatgctt tggtattgct aacgtataga      780

aaaggtaatg aaaagctcat ggttctataa aaaagatgta cccacgaaaa taataggctt      840

tgcctatttc cccatgtaat atgggggcag ttttctctta tgctctttct taacatattg      900

aataaataca aaatgcagct ttgtgggaat aaaaatattt ttgtttttat tcttatagtt      960

agacaaaatt ttaatctttt ttgtgctata acaagattaa aatttgtggg aacattaaga     1020

aatattgttg tcacaaataa aaaggagagt gggaacaatt gctataaaaa acgcagaaat     1080

taagattaga gttacaaaag agcaaaaaga attatttaag aaaattgcaa aagctgaaaa     1140

tatgagtatg agtgaattta ttattgtgac cacagaatat ttagccagaa aaaaagatga     1200

aaatatgaaa tcaaaagaca tgatcgagag aagagctgcg aagactgaag aaaaaattat     1260

gaagctaaaa aagaaactaa ataaaaacag gtaatataga ttacagtttt aagcttgttt     1320

tccctataga ctagagtaaa tatataaata tacctgtcaa gggcttataa gcccctttag     1380

ggggtgcgta gcacccttga caggtatatt tatatatttt agggtgccat taagggaaac     1440

aagctttaaa atgcctttaa aggcatttta aaataaataa aaaaaagatg gtttttacca     1500

tcttttttaa ctcccgaaag ggagttcttt cttttcttga tactatacgt aactatttcg     1560

atttgccctg aacctaatca aagctagata aattcagtat tagggcataa aaaaacttgc     1620

tttttcgggt ggaaatctgt ataatttaaa ttgcttagat aaaaattacc aattccatac     1680

gaaaggagca agttttacat aaggttaaag ccttatgtga attctcattt aattacatga     1740

ataataataa cacagaaagt gaagaattaa aagagcaaag tcaactattg cttgacaaat     1800

gcacaaaaaa gaaaaagaaa aatcctaaat ttagtagtta tatagaacca ttagtaagca     1860

agaaattatc tgaaagaata aaggaatgtg gtgacttttt gcagatgtta tctgatttaa     1920

accttgaaaa ttcgaaactg catagagcaa gtttttgtgg taacagattt tgtcctatgt     1980

gtagctggcg tattgcttgt aaggatagtt tggaaatatc tattctcatg gagcatttac     2040

gcaaagagga aagcaaagaa tttatctttt tgaccttaac aactccaaat gtgaaaggtg     2100

cggaccttga taattccata aaagcataca ataaagcatt taaaaagtta atggaacgca     2160

aagaggtcaa gagcatagta aaaggctaca taagaaagct agaagtaacc tataatttgg     2220

acaagagttc caaatcatat aatacttatc acccacattt ccatgtggta ctagcagtca     2280

atagaagtta ctttaaaaag caaaatctat atataaacca tcatagatgg cttagtttgt     2340

ggcaagagtc aactggtgat tattcgataa ctcaagttga tgtaagaaag gctaaaatta     2400

acgattataa agaggtttat gagcttgcta agtattcggc taaggattcc gactatttaa     2460

tcaatagaga agtgtttacg gtattctaca aatctttaaa gggtaaacag gtacttgtat     2520

ttagtggatt atttaaagac gctcataaaa tgtataagaa tggagagcta gatctgtata     2580

agaagttgga tactatcgaa tatgcttata tggtaagtta taactggctt aaaaagaagt     2640

atgatacttc aaatattaga gaattaactg aggaagaaaa gcagaaattc aataaaaatt     2700

taatcgaaga tgtggatatt gagtaggtgg gattatatct cacctttttt attgtctttt     2760

catgttgaaa ttttgacgct taatgcatga agtattgaca agtttaaaaa ttacggtttt     2820

taatccttag ttgattagca ggattatggc cggaatgctc cgtccagtcc tgttaaggaa     2880

ttaaaattcc ctaaaaccct tggctatgat ttatagcgag aatcgtcaat taaaaattta     2940

ataggtgcta tgaaagtcga ttaataatta attttaaaat gcaatatgaa acataattac     3000

aagaatttga cttttaatac aagaattgat atcatagtta cattaatacg gatcccggca     3060

gtttttcttt ttcggcaagt gttcaagaag ttattaagtc gggagtgcag tcgaagtggg     3120

caagttgaaa aattcacaaa aatgtggtat aatatctttg ttcattagag cgataaactt     3180

gaatttgaga gggaacttag atggtatttg aaaaaattga taaaaatagt tggaacagaa     3240

aagagtattt tgaccactac tttgcaagtg taccttgtac ctacagcatg accgttaaag     3300

tggatatcac acaaataaag gaaaagggaa tgaaactata tcctgcaatg ctttattata     3360

ttgcaatgat tgtaaaccgc cattcagagt ttaggacggc aatcaatcaa gatggtgaat     3420

tggggatata tgatgagatg ataccaagct atacaatatt tcacaatgat actgaaacat     3480

tttccagcct ttggactgag tgtaagtctg actttaaatc atttttagca gattatgaaa     3540

gtgatacgca acggtatgga aacaatcata gaatggaagg aaagccaaat gctccggaaa     3600

acatttttaa tgtatctatg ataccgtggt caaccttcga tggctttaat ctgaatttgc     3660

agaaaggata tgattatttg attcctattt ttactatggg gaaatattat aaagaagata     3720

acaaaattat acttcctttg gcaattcaag ttcatcacgc agtatgtgac ggatttcaca     3780

tttgccgttt tgtaaacgaa ttgcaggaat tgataaatag ttaacttcag gtttgtctgt     3840

aactaaaaac tagtatttaa ccgagctcga attcactggc cgtcgtttta caacgtcgtg     3900

actgggaaaa ccctggcgtt acccaactta atcgccttgc agcacatccc cctttcgcca     3960

gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc ccaacagttg cgcagcctga     4020

atggcgaatg gcgcctgatg cggtattttc tccttacgca tctgtgcggt atttcacacc     4080

gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc cagccccgac     4140

acccgccaac acccgctgac gcgccctgac gggcttgtct gctcccggca tccgcttaca     4200

gacaagctgt gaccgtctcc gggagctgca tgtgtcagag gttttcaccg tcatcaccga     4260

aacgcgcgag acgaaagggc ctcgtgatac gcctattttt ataggttaat gtcatgataa     4320

taatggtttc ttagacgtca ggtggcactt ttcggggaaa tgtgcgcgga acccctattt     4380

gtttattttt ctaaatacat tcaaatatgt atccgctcat gagacaataa ccctgataaa     4440

tgcttcaata atattgaaaa aggaagagta tgagtattca acatttccgt gtcgccctta     4500

ttcccttttt tgcggcattt tgccttcctg tttttgctca cccagaaacg ctggtgaaag     4560

taaaagatgc tgaagatcag ttgggtgcac gagtgggtta catcgaactg gatctcaaca     4620

gcggtaagat ccttgagagt tttcgccccg aagaacgttt tccaatgatg agcactttta     4680

aagttctgct atgtggcgcg gtattatccc gtattgacgc cgggcaagag caactcggtc     4740

gccgcataca ctattctcag aatgacttgg ttgagtactc accagtcaca gaaaagcatc     4800

ttacggatgg catgacagta agagaattat gcagtgctgc cataaccatg agtgataaca     4860

ctgcggccaa cttacttctg acaacgatcg gaggaccgaa ggagctaacc gcttttttgc     4920

acaacatggg ggatcatgta actcgccttg atcgttggga accggagctg aatgaagcca     4980

taccaaacga cgagcgtgac accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac     5040

tattaactgg cgaactactt actctagctt cccggcaaca attaatagac tggatggagg     5100

cggataaagt tgcaggacca cttctgcgct cggcccttcc ggctggctgg tttattgctg     5160

ataaatctgg agccggtgag cgtgggtctc gcggtatcat tgcagcactg gggccagatg     5220

gtaagccctc ccgtatcgta gttatctaca cgacggggag tcaggcaact atggatgaac     5280

gaaatagaca gatcgctgag ataggtgcct cactgattaa gcattggtaa ctgtcagacc     5340

aagtttactc atatatactt tagattgatt taaaacttca tttttaattt aaaaggatct     5400

aggtgaagat cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc     5460

actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc     5520

gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg     5580

atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa     5640

atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc     5700

ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt     5760

gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa     5820

cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa ctgagatacc     5880

tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc     5940

cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg ggaaacgcct     6000

ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga tttttgtgat     6060

gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt ttacggttcc     6120

tggccttttg ctggcctttt gctcacatgt tctttcctgc gttatcccct gattctgtgg     6180

ataaccgtat taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc     6240

gcagcgagtc agtgagcgag gaagcggaag a                                    6271


<210>  126
<211>  2793
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OREP

<400>  126
cacgataaaa caaggtttta aggataagaa aagtcatgag atttatagta aatcttgtga       60

ctttttttat tgaatagtag agagagttcg gaagtataac acgctatatt cttgatattt      120

ttagaatagc aagcattgga tttgtcctga cactttccca aaaattaagg agttattcct      180

taaaccaaaa agattaatgt gggaacaaat ttagtgtatc catttttgaa gggcgcactt      240

atacaccacc aaaatggtgt gtgcgaaatc tttaaaaaag atttatcaaa aagctttttt      300

aaagctggga catttagaaa atcaataatg ttttttgccc aatacgctag tcttaaaatc      360

tgcaaggttg ataactattt agtcccaggt attagaatgg ggcatatata tacaaagtat      420

atatatgcgt aaatatatgt gggactgtgg gaacaaaatt gcgtgctaaa attgtattga      480

aaaggtaatg aaaaggtcat gctttggtat tgctaacgta tagaaaaggt aatgaaaagc      540

tcatggttct ataaaaaaga tgtacccacg aaaataatag gctttgccta tttccccatg      600

taatatgggg gcagttttct cttatgctct ttcttaacat attgaataaa tacaaaatgc      660

agctttgtgg gaataaaaat atttttgttt ttattcttat agttagacaa aattttaatc      720

ttttttgtgc tataacaaga ttaaaatttg tgggaacatt aagaaatatt gttgtcacaa      780

ataaaaagga gagtgggaac aattgctata aaaaacgcag aaattaagat tagagttaca      840

aaagagcaaa aagaattatt taagaaaatt gcaaaagctg aaaatatgag tatgagtgaa      900

tttattattg tgaccacaga atatttagcc agaaaaaaag atgaaaatat gaaatcaaaa      960

gacatgatcg agagaagagc tgcgaagact gaagaaaaaa ttatgaagct aaaaaagaaa     1020

ctaaataaaa acaggtaata tagattacag ttttaagctt gttttcccta tagactagag     1080

taaatatata aatatacctg tcaagggctt ataagcccct ttagggggtg cgtagcaccc     1140

ttgacaggta tatttatata ttttagggtg ccattaaggg aaacaagctt taaaatgcct     1200

ttaaaggcat tttaaaataa ataaaaaaaa gatggttttt accatctttt ttaactcccg     1260

aaagggagtt ctttcttttc ttgatactat acgtaactat ttcgatttgc cctgaaccta     1320

atcaaagcta gataaattca gtattagggc ataaaaaaac ttgctttttc gggtggaaat     1380

ctgtataatt taaattgctt agataaaaat taccaattcc atacgaaagg agcaagtttt     1440

acataaggtt aaagccttat gtgaattctc atttaattac atgaataata ataacacaga     1500

aagtgaagaa ttaaaagagc aaagtcaact attgcttgac aaatgcacaa aaaagaaaaa     1560

gaaaaatcct aaatttagta gttatataga accattagta agcaagaaat tatctgaaag     1620

aataaaggaa tgtggtgact ttttgcagat gttatctgat ttaaaccttg aaaattcgaa     1680

actgcataga gcaagttttt gtggtaacag attttgtcct atgtgtagct ggcgtattgc     1740

ttgtaaggat agtttggaaa tatctattct catggagcat ttacgcaaag aggaaagcaa     1800

agaatttatc tttttgacct taacaactcc aaatgtgaaa ggtgcggacc ttgataattc     1860

cataaaagca tacaataaag catttaaaaa gttaatggaa cgcaaagagg tcaagagcat     1920

agtaaaaggc tacataagaa agctagaagt aacctataat ttggacaaga gttccaaatc     1980

atataatact tatcacccac atttccatgt ggtactagca gtcaatagaa gttactttaa     2040

aaagcaaaat ctatatataa accatcatag atggcttagt ttgtggcaag agtcaactgg     2100

tgattattcg ataactcaag ttgatgtaag aaaggctaaa attaacgatt ataaagaggt     2160

ttatgagctt gctaagtatt cggctaagga ttccgactat ttaatcaata gagaagtgtt     2220

tacggtattc tacaaatctt taaagggtaa acaggtactt gtatttagtg gattatttaa     2280

agacgctcat aaaatgtata agaatggaga gctagatctg tataagaagt tggatactat     2340

cgaatatgct tatatggtaa gttataactg gcttaaaaag aagtatgata cttcaaatat     2400

tagagaatta actgaggaag aaaagcagaa attcaataaa aatttaatcg aagatgtgga     2460

tattgagtag gtgggattat atctcacctt ttttattgtc ttttcatgtt gaaattttga     2520

cgcttaatgc atgaagtatt gacaagttta aaaattacgg tttttaatcc ttagttgatt     2580

agcaggatta tggccggaat gctccgtcca gtcctgttaa ggaattaaaa ttccctaaaa     2640

cccttggcta tgatttatag cgagaatcgt caattaaaaa tttaataggt gctatgaaag     2700

tcgattaata attaatttta aaatgcaata tgaaacataa ttacaagaat ttgactttta     2760

atacaagaat tgatatcata gttacattaa tac                                  2793


<210>  127
<211>  2793
<212>  DNA
<213>  Clostridium beijerinckii

<400>  127
cacgataaaa caaggtttta aggataagaa aagtcatgag atttatagta aatcttgtga       60

ctttttttat tgaatagtag agagagttcg gaagtataac acgctatatt cttgatattt      120

ttagaatagc aagcattgga tttgtcctga cactttccca aaaattaagg agttattcct      180

taaaccaaaa agattaatgt gggaacaaat ttagtgtatc catttttgaa gggcgcactt      240

atacaccacc aaaatggtgt gtgcgaaatc tttaaaaaag atttatcaaa aagctttttt      300

aaagctggga catttagaaa atcaataatg ttttttgccc aatacgctag tcttaaaatc      360

tgcaaggttg ataactattt agtcccaggt attagaatgg ggcatatata tacaaagtat      420

atatatgcgt aaatatatgt gggactgtgg gaacaaaatt gcgtgctaaa attgtattga      480

aaaggtaatg aaaaggtcat gctttggtat tgctaacgta tagaaaaggt aatgaaaagc      540

tcatggttct ataaaaaaga tgtacccacg aaaataatag gctttgccta tttccccatg      600

taatatgggg gcagttttct cttatgctct ttcttaacat attgaataaa tacaaaatgc      660

agctttgtgg gaataaaaat atttttgttt ttattcttat agttagacaa aattttaatc      720

ttttttgtgc tataacaaga ttaaaatttg tgggaacatt aagaaatatt gttgtcacaa      780

ataaaaagga gagtgggaac aattgctata aaaaacgcag aaattaagat tagagttaca      840

aaagagcaaa aagaattatt taagaaaatt gcaaaagctg aaaatatgag tatgagtgaa      900

tttattattg tgaccacaga atatttagcc agaaaaaaag atgaaaatat gaaatcaaaa      960

gacatgatcg agagaagagc tgcgaagact gaagaaaaaa ttatgaagct aaaaaagaaa     1020

ctaaataaaa acaggtaata tagattacag ttttaagctt gttttcccta tagactagag     1080

taaatatata aatatacctg tcaagggctt ataagcccct ttagggggtg cgtagcaccc     1140

ttgacaggta tatttatata ttttagggtg ccattaaggg aaacaagctt taaaatgcct     1200

ttaaaggcat tttaaaataa ataaaaaaaa gatggttttt accatctttt ttaactcccg     1260

aaagggagtt ctttcttttc ttgatactat acgtaactat ttcgatttgc cctgaaccta     1320

atcaaagcta gataaattca gtattagggc ataaaaaaac ttgctttttc gggtggaaat     1380

ctgtataatt taaattgctt agataaaaat taccaattcc atacgaaagg agcaagtttt     1440

acataaggtt aaagccttat gtgaattctc atttaattac atgaataata ataacacaga     1500

aagtgaagaa ttaaaagagc aaagtcaact attgcttgac aaatgcacaa aaaagaaaaa     1560

gaaaaatcct aaatttagta gttatataga accattagta agcaagaaat tatctgaaag     1620

aataaaggaa tgtggtgact ttttgcagat gttatctgat ttaaaccttg aaaattcgaa     1680

actgcataga gcaagttttt gtggtaacag attttgtcct atgtgtagct ggcgtattgc     1740

ttgtaaggat agtttggaaa tatctattct catggagcat ttacgcaaag aggaaagcaa     1800

agaatttatc tttttgacct taacaactcc aaatgtgaaa ggtgcggacc ttgataattc     1860

cataaaagca tacaataaag catttaaaaa gttaatggaa cgcaaagagg tcaagagcat     1920

agtaaaaggc tacataagaa agctagaagt aacctataat ttggacaaga gttccaaatc     1980

atataatact tatcacccac atttccatgt ggtactagca gtcaatagaa gttactttaa     2040

aaagcaaaat ctatatataa accatcatag atggcttagt ttgtggcaag agtcaactgg     2100

tgattattcg ataactcaag ttgatgtaag aaaggctaaa attaacgatt ataaagaggt     2160

ttatgagctt gctaagtatt cggctaagga ttccgactat ttaatcaata gagaagtgtt     2220

tacggtattc tacaaatctt taaagggtaa acaggtactt gtatttagtg gattatttaa     2280

agacgctcat aaaatgtata agaatggaga gctagatctg tataagaagt tggatactat     2340

cgaatatgct tatatggtaa gttataactg gcttaaaaag aagtatgata cttcaaatat     2400

tagagaatta actgaggaag aaaagcagaa attcaataaa aatttaatcg aagatgtgga     2460

tattgagtag gtgggattat atctcacctt ttttattgtc ttttcatgtt gaaattttga     2520

cgcttaatgc atgaagtatt gacaagttta aaaattacgg tttttaatcc ttagttgatt     2580

agcaggatta tggccggaat gctccgtcca gtcctgttaa ggaattaaaa ttccctaaaa     2640

cccttggcta tgatttatag cgagaatcgt caattaaaaa tttaataggt gctatgaaag     2700

tcgattaata attaatttta aaatgcaata tgaaacataa ttacaagaat ttgactttta     2760

atacaagaat tgatatcata gttacattaa tac                                  2793


<210>  128
<211>  329
<212>  PRT
<213>  Clostridium beijerinckii

<400>  128

Met Asn Asn Asn Asn Thr Glu Ser Glu Glu Leu Lys Glu Gln Ser Gln 
1               5                   10                  15      


Leu Leu Leu Asp Lys Cys Thr Lys Lys Lys Lys Lys Asn Pro Lys Phe 
            20                  25                  30          


Ser Ser Tyr Ile Glu Pro Leu Val Ser Lys Lys Leu Ser Glu Arg Ile 
        35                  40                  45              


Lys Glu Cys Gly Asp Phe Leu Gln Met Leu Ser Asp Leu Asn Leu Glu 
    50                  55                  60                  


Asn Ser Lys Leu His Arg Ala Ser Phe Cys Gly Asn Arg Phe Cys Pro 
65                  70                  75                  80  


Met Cys Ser Trp Arg Ile Ala Cys Lys Asp Ser Leu Glu Ile Ser Ile 
                85                  90                  95      


Leu Met Glu His Leu Arg Lys Glu Glu Ser Lys Glu Phe Ile Phe Leu 
            100                 105                 110         


Thr Leu Thr Thr Pro Asn Val Lys Gly Ala Asp Leu Asp Asn Ser Ile 
        115                 120                 125             


Lys Ala Tyr Asn Lys Ala Phe Lys Lys Leu Met Glu Arg Lys Glu Val 
    130                 135                 140                 


Lys Ser Ile Val Lys Gly Tyr Ile Arg Lys Leu Glu Val Thr Tyr Asn 
145                 150                 155                 160 


Leu Asp Lys Ser Ser Lys Ser Tyr Asn Thr Tyr His Pro His Phe His 
                165                 170                 175     


Val Val Leu Ala Val Asn Arg Ser Tyr Phe Lys Lys Gln Asn Leu Tyr 
            180                 185                 190         


Ile Asn His His Arg Trp Leu Ser Leu Trp Gln Glu Ser Thr Gly Asp 
        195                 200                 205             


Tyr Ser Ile Thr Gln Val Asp Val Arg Lys Ala Lys Ile Asn Asp Tyr 
    210                 215                 220                 


Lys Glu Val Tyr Glu Leu Ala Lys Tyr Ser Ala Lys Asp Ser Asp Tyr 
225                 230                 235                 240 


Leu Ile Asn Arg Glu Val Phe Thr Val Phe Tyr Lys Ser Leu Lys Gly 
                245                 250                 255     


Lys Gln Val Leu Val Phe Ser Gly Leu Phe Lys Asp Ala His Lys Met 
            260                 265                 270         


Tyr Lys Asn Gly Glu Leu Asp Leu Tyr Lys Lys Leu Asp Thr Ile Glu 
        275                 280                 285             


Tyr Ala Tyr Met Val Ser Tyr Asn Trp Leu Lys Lys Lys Tyr Asp Thr 
    290                 295                 300                 


Ser Asn Ile Arg Glu Leu Thr Glu Glu Glu Lys Gln Lys Phe Asn Lys 
305                 310                 315                 320 


Asn Leu Ile Glu Asp Val Asp Ile Glu 
                325                 


<210>  129
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus COG5655

<400>  129

Met Cys Gln Lys Arg Ser Asp Tyr Ser Asp Glu Lys Ala Trp Leu Lys 
1               5                   10                  15      


Asp Lys Ser Lys Asp Gly Lys Val Glu Pro Trp Arg Glu Lys Lys Glu 
            20                  25                  30          


Ala Asn Val Lys Tyr Phe Glu Leu Leu Lys Ile Leu Met Phe Lys Lys 
        35                  40                  45              


Ala Glu Arg Val Tyr Arg Cys Asn Glu Leu Leu Glu Leu Gln Lys Val 
    50                  55                  60                  


Asn Glu Thr Gly Glu Asn Lys Leu Cys Pro Asn Trp Phe Cys Lys Ser 
65                  70                  75                  80  


Leu Leu Cys Pro Met Cys Asn Trp Arg Lys Pro Met Lys Ser Asp Leu 
                85                  90                  95      


Gln Asp Gly Leu Tyr Val Lys Arg Val Ile Ser Tyr Gly Pro Leu Leu 
            100                 105                 110         


Lys Trp Lys His Leu Lys Leu Asn Leu Lys Asn Val Glu Asp Gly Asp 
        115                 120                 125             


Leu Leu Asn Lys Ser Leu Asp Glu Met Ala Leu Gly Phe Lys Arg Thr 
    130                 135                 140                 


Met Gly Phe Lys Lys Ile Ala Lys Asn Phe Val Gly Phe Met Lys Ser 
145                 150                 155                 160 


Thr Glu Ile Thr Tyr Asn Glu Lys Asp Asn Ser Tyr Asn Gln His Met 
                165                 170                 175     


His Val Leu Phe Cys Ser Glu Gln Thr Tyr Phe Lys Asn Phe Ile Asn 
            180                 185                 190         


Asn Thr Pro Gln Glu Phe Trp Asn Lys Arg Trp Ser Lys Ala Met Lys 
        195                 200                 205             


Leu Asp Tyr Asp Pro Gln Val Met Lys Leu Trp Thr Met Tyr Lys Lys 
    210                 215                 220                 


Glu Ile Lys Asn Tyr Ile Gln Thr Ala Leu Gln Glu Thr Ala Lys Tyr 
225                 230                 235                 240 


Asp Val Lys Asp Met Asp Ser Ala Thr Ile Asp Asp Glu Lys Ser Leu 
                245                 250                 255     


<210>  130
<211>  768
<212>  DNA
<213>  Enterococcus faecalis

<400>  130
gtgaggagga tatatttgaa tacatacgaa caaattaata aagtgaaaaa aatacttcgg       60

aaacatttaa aaaataacct tattggtact tacatgtttg gatcaggagt tgagagtgga      120

ctaaaaccaa atagtgatct tgacttttta gtcgtcgtat ctgaaccatt gacagatcaa      180

agtaaagaaa tacttataca aaaaattaga cctatttcaa agaaaatagg agataaaagc      240

aacttacgat atattgaatt aacaattatt attcagcaag aaatggtacc gtggaatcat      300

cctcccaaac aagaatttat ttatggagaa tggttacaag agctttatga acaaggatac      360

attcctcaga aggaattaaa ttcagattta accataatgc tttaccaagc aaaacgaaaa      420

aataaaagaa tatacggaaa ttatgactta gaggaattac tacctgatat tccattttct      480

gatgtgagaa gagccattat ggattcgtca gaggaattaa tagataatta tcaggatgat      540

gaaaccaact ctatattaac tttatgccgt atgattttaa ctatggacac gggtaaaatc      600

ataccaaaag atattgcggg aaatgcagtg gctgaatctt ctccattaga acatagggag      660

agaattttgt tagcagttcg tagttatctt ggagagaata ttgaatggac taatgaaaat      720

gtaaatttaa ctataaacta tttaaataac agattaaaaa aattataa                   768


<210>  131
<211>  738
<212>  DNA
<213>  Clostridium difficile

<400>  131
atgaacaaaa atataaaata ttctcaaaac tttttaacga gtgaaaaagt actcaaccaa       60

ataataaaac aattgaattt aaaagaaacc gataccgttt acgaaattgg aacaggtaaa      120

gggcatttaa cgacgaaact ggctaaaata agtaaacagg taacgtctat tgaattagac      180

agtcatctat tcaacttatc gtcagaaaaa ttaaaactga atactcgtgt cactttaatt      240

caccaagata ttctacagtt tcaattccct aacaaacaga ggtataaaat tgttgggagt      300

attccttacc atttaagcac acaaattatt aaaaaagtgg tttttgaaag ccatgcgtct      360

gacatctatc tgattgttga agaaggattc tacaagcgta ccttggatat tcaccgaaca      420

ctagggttgc tcttgcacac tcaagtctcg attcagcaat tgcttaagct gccagcggaa      480

tgctttcatc ctaaaccaaa agtaaacagt gtcttaataa aacttacccg ccataccaca      540

gatgttccag ataaatattg gaagctatat acgtactttg tttcaaaatg ggtcaatcga      600

gaatatcgtc aactgtttac taaaaatcag tttcatcaag caatgaaaca cgccaaagta      660

aacaatttaa gtaccgttac ttatgagcaa gtattgtcta tttttaatag ttatctatta      720

tttaacggga ggaaataa                                                    738


<210>  132
<211>  3792
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized Mad7 CDS for B. subtilis

<400>  132
atgaacaacg gcacaaataa ttttcagaac tttattggca tttcatcatt gcagaaaacg       60

ttaagaaatg ctttaattcc gacggaaaca acgcaacagt ttattgttaa aaacggaatt      120

attaaagaag atgaattaag aggcgaaaac agacagattt taaaagatat tatggatgac      180

tactacagag gatttatttc tgaaacatta tcatctattg atgacattga ttggacaagc      240

ttatttgaaa aaatggaaat tcagttaaaa aatggtgata ataaagatac attaattaaa      300

gaacagacag aatatagaaa agcaattcat aaaaaatttg cgaacgacga tagatttaaa      360

aacatgttta gcgccaaatt aatttcagac attttacctg aatttgttat tcataacaat      420

aattattcag catcagaaaa agaagaaaaa acacaggtga ttaaattgtt ttcaagattt      480

gcgacaagct ttaaagatta ctttaaaaac agagcaaatt gcttttcagc ggacgatatt      540

tcatcaagca gctgccatag aattgttaac gacaatgcag aaattttttt ttcaaatgcg      600

ttagtttaca gaagaattgt aaaatcatta agcaatgacg atattaacaa aatttcaggc      660

gatatgaaag attcattaaa agaaatgtca ttagaagaaa tttattctta cgaaaaatat      720

ggcgaattta ttacacagga aggcattagc ttttataatg atatttgtgg caaagtgaat      780

tcttttatga acttatattg tcagaaaaat aaagaaaaca aaaatttata caaacttcag      840

aaacttcata aacagattct gtgcattgcg gacacaagct atgaagttcc gtataaattt      900

gaatcagacg aagaagtgta ccaatcagtt aacggctttc ttgataacat tagcagcaaa      960

catattgttg aaagattaag aaaaattggc gataactata acggctacaa cttagataaa     1020

atttatattg tgtccaaatt ttacgaaagc gttagccaaa aaacatacag agactgggaa     1080

acaattaata cagccttaga aattcattac aataatattt tgccgggtaa cggtaaatca     1140

aaagccgaca aagtaaaaaa agcggttaaa aatgatttac agaaatccat tacagaaatt     1200

aatgaactgg tgtcaaacta taaattatgc tcagacgaca acattaaagc ggaaacatat     1260

attcatgaaa ttagccatat tttgaataac tttgaagcac aggaattgaa atacaatccg     1320

gaaattcatc tggttgaatc cgaattaaaa gcgtcagaac ttaaaaacgt gttagacgtg     1380

attatgaatg cgtttcattg gtgttcagtt tttatgacag aagaacttgt tgataaagac     1440

aacaattttt atgcggaatt agaagaaatt tacgatgaaa tttatccggt aatttcatta     1500

tacaacttag ttagaaacta cgttacacag aaaccgtaca gcacgaaaaa aattaaattg     1560

aactttggaa ttccgacgtt agcagacggt tggtcaaaat ccaaagaata ttctaataac     1620

gctattattt taatgagaga caatttatat tatttaggca tttttaatgc gaaaaataaa     1680

ccggacaaaa aaattattga aggtaatacg tcagaaaata aaggtgacta caaaaaaatg     1740

atttataatt tgttaccggg tccgaacaaa atgattccga aagttttttt gagcagcaaa     1800

acgggcgtgg aaacgtataa accgagcgcc tatattctgg aaggctataa acagaataaa     1860

catattaaat cttcaaaaga ctttgatatt acattttgtc atgatttaat tgactacttt     1920

aaaaactgta ttgcaattca tccggaatgg aaaaactttg gttttgattt tagcgacaca     1980

tcaacatatg aagacatttc cggcttttat agagaagtag aattacaagg ttacaaaatt     2040

gattggacat acattagcga aaaagacatt gatttattac aggaaaaagg tcaattatat     2100

ttatttcaga tttataacaa agatttttca aaaaaatcaa caggcaatga caaccttcat     2160

acaatgtact taaaaaatct tttttcagaa gaaaatctta aagatattgt tttaaaactt     2220

aacggcgaag cggaaatttt ttttagaaaa agcagcatta aaaacccgat tattcataaa     2280

aaaggctcaa ttttagttaa cagaacatac gaagcagaag aaaaagacca gtttggcaac     2340

attcaaattg tgagaaaaaa tattccggaa aacatttatc aggaattata caaatacttt     2400

aacgataaaa gcgacaaaga attatctgat gaagcagcca aattaaaaaa tgtagtggga     2460

catcatgaag cagcgacgaa tattgttaaa gactatagat acacgtatga taaatacttt     2520

cttcatatgc ctattacgat taattttaaa gccaataaaa cgggttttat taatgataga     2580

attttacagt atattgctaa agaaaaagac ttacatgtga ttggcattga tagaggcgaa     2640

agaaacttaa tttacgtgtc cgtgattgat acatgtggta atattgttga acagaaaagc     2700

tttaacattg taaacggcta cgactatcag attaaattaa aacaacagga aggcgctaga     2760

cagattgcga gaaaagaatg gaaagaaatt ggtaaaatta aagaaattaa agaaggctac     2820

ttaagcttag taattcatga aatttctaaa atggtaatta aatacaatgc aattattgcg     2880

atggaagatt tgtcttatgg ttttaaaaaa ggcagattta aagttgaaag acaagtttac     2940

cagaaatttg aaacaatgtt aattaataaa ttaaactatt tagtatttaa agatatttca     3000

attacagaaa atggcggttt attaaaaggt tatcagttaa catacattcc tgataaactt     3060

aaaaacgtgg gtcatcagtg cggctgcatt ttttatgtgc ctgctgcata cacgagcaaa     3120

attgatccga caacaggctt tgtgaatatt tttaaattta aagacttaac agtggacgca     3180

aaaagagaat ttattaaaaa atttgactca attagatatg actcagaaaa aaatttattt     3240

tgctttacat ttgactacaa taactttatt acgcaaaaca cggttatgag caaatcatca     3300

tggtcagtgt atacatacgg cgtgagaatt aaaagaagat ttgtgaacgg cagattttca     3360

aacgaatcag atacaattga cattacaaaa gatatggaaa aaacgttgga aatgacggac     3420

attaactgga gagatggcca tgatcttaga caagacatta ttgattatga aattgttcag     3480

catatttttg aaatttttag attaacagtg caaatgagaa actccttgtc tgaattagaa     3540

gacagagatt acgatagatt aatttcacct gtattaaacg aaaataacat tttttatgac     3600

agcgcgaaag cgggcgatgc acttcctaaa gatgccgatg caaatggtgc gtattgtatt     3660

gcattaaaag gcttatatga aattaaacaa attacagaaa attggaaaga agatggtaaa     3720

ttttcaagag ataaattaaa aattagcaat aaagattggt ttgactttat tcagaataaa     3780

agatatttat aa                                                         3792


<210>  133
<211>  10469
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCas9cond

<400>  133
catggataaa aagtacagta ttggtctaga cataggaact aactctgttg ggtgggctgt       60

tataacagat gaatataaag ttccatcaaa aaaatttaaa gtattaggaa acactgatag      120

acattcaata aaaaaaaact tgataggtgc tttattattc gattcaggag agactgctga      180

agctacacgt ttaaaaagaa cagctagacg tagatataca agaagaaaaa ataggatatg      240

ttatcttcaa gaaattttta gtaatgaaat ggcaaaagtt gatgattcat tctttcacag      300

actagaagaa agtttcttag ttgaagaaga taagaagcat gaaagacacc ctatttttgg      360

taatatcgta gatgaagtag catatcatga gaagtatcca actatctatc atttaagaaa      420

gaaattagtt gattctacag ataaagctga tctgagatta atatatttag ctttagctca      480

tatgattaaa tttagaggac attttttaat agaaggtgat ttaaacccag acaacagcga      540

tgtagataaa ttatttatcc aattagttca aacttataat caattattcg aagagaatcc      600

aattaatgca agtggtgtag acgctaaggc tatattatca gctagattat caaaatctag      660

aagattagaa aatctaatag ctcaacttcc tggagaaaag aaaaatggac tttttgggaa      720

cctaatagct ctctcactcg gactaacacc aaattttaaa agcaattttg atcttgctga      780

agacgcaaag ttacaactat caaaggatac atacgatgat gatttagata atttgttagc      840

tcaaataggt gatcaatatg ctgatttgtt tcttgcagca aaaaacttaa gtgatgcaat      900

tttactatca gatatactta gagtaaatac agaaataaca aaggctcctt tatcagcaag      960

tatgattaaa cgatatgatg agcatcatca agatttaaca ttattaaagg cacttgtaag     1020

acaacaatta ccagaaaaat ataaagaaat tttctttgat caatctaaaa atggatatgc     1080

tggatatata gacggtggag caagtcaaga agagttttat aaatttataa agcctatttt     1140

agaaaaaatg gatggaactg aagaattact tgttaaactt aacagagaag atttacttag     1200

aaaacaaaga acttttgata atggttcaat tcctcaccaa attcatttag gagaattaca     1260

tgctatacta agaagacaag aagattttta tccatttctt aaagataata gagaaaaaat     1320

tgaaaaaatt ttaactttta gaataccata ttatgtagga ccacttgcaa ggggaaattc     1380

aagatttgca tggatgacta gaaaatcaga agaaactata accccgtgga attttgaaga     1440

agtagtagat aaaggagcta gtgctcaatc atttatagaa agaatgacaa attttgataa     1500

gaatcttcct aacgaaaagg ttttgccaaa gcatagcctt ctttatgagt attttacagt     1560

ttataatgag cttactaaag taaaatacgt tacagaagga atgagaaaac cagcattttt     1620

gtctggtgaa caaaagaaag caatagtaga cctattattt aaaacaaata ggaaggttac     1680

cgtaaagcaa cttaaagaag attacttcaa aaaaattgaa tgctttgata gtgttgaaat     1740

atcaggagtt gaagatagat ttaatgcttc acttggtaca tatcacgatc tcttaaaaat     1800

tataaaagat aaggattttt tagataatga agaaaatgaa gatattcttg aagatatagt     1860

attaacattg acactttttg aagatagaga aatgatagaa gaaagattaa aaacatatgc     1920

acatcttttt gatgataagg ttatgaagca acttaaaaga agaagatata caggttgggg     1980

acgtttgtca agaaagctaa ttaatggtat tagagataaa caatcaggaa agactattct     2040

cgattttctt aaatcagatg gatttgctaa tagaaacttt atgcaattaa ttcatgatga     2100

ttctcttact ttcaaagagg atattcaaaa ggctcaagtt tctggacaag gcgatagctt     2160

acacgaacac attgctaacc ttgcagggag ccccgctatc aaaaaaggaa ttttacaaac     2220

agttaaagtt gtagatgaac ttgttaaagt tatgggaaga cacaaacctg agaatatagt     2280

tatagaaatg gccagagaaa atcaaacaac acaaaaagga caaaaaaatt ctagagagag     2340

aatgaagaga attgaagaag gaataaaaga gctaggatca caaatattaa aagaacatcc     2400

agttgaaaat actcaattgc aaaatgaaaa gttatatttg tattacttac aaaatggaag     2460

agatatgtat gttgatcaag aactcgatat taatagatta agtgactatg atgttgatca     2520

tattgttcct caatcatttt taaaagatga ttcaatcgat aacaaagtat taactagatc     2580

agataaaaat agaggaaagt cagataatgt accatctgaa gaagttgtta aaaaaatgaa     2640

gaactattgg agacaacttt taaatgcaaa gctaattaca caaagaaaat ttgacaattt     2700

aacaaaagca gaaagaggag gattaagcga attagacaaa gctggattta taaaaagaca     2760

acttgttgag acaagacaaa taactaagca tgttgctcaa atacttgatt caagaatgaa     2820

tacaaaatat gatgaaaatg ataaattaat cagagaagta aaagtaataa cattaaagtc     2880

aaaattagta tcagatttca gaaaggattt tcaattttac aaagttcgtg aaataaataa     2940

ctatcatcat gctcatgatg catacttaaa tgctgttgta ggaactgctc ttattaagaa     3000

atatcctaaa ctagaaagcg aatttgttta tggagattat aaagtttatg atgtgcgcaa     3060

aatgatcgcg aaatccgaac aagaaatcgg taaggctaca gcaaaatatt tcttttatag     3120

taatataatg aattttttta agacagaaat aactttggct aatggtgaaa tcagaaaaag     3180

accacttatc gaaacaaatg gagagacagg agaaatagta tgggataaag gaagagattt     3240

tgctactgtt agaaaagtac taagtatgcc acaagtaaat atcgtaaaga aaactgaagt     3300

tcaaactgga ggtttctcta aggaatcaat tttacctaag agaaattcag ataagttaat     3360

tgcaaggaaa aaagattggg acccaaaaaa atacggtggt tttgatagtc caacagttgc     3420

ctatagtgtt cttgtagtag cgaaagttga gaaaggtaag tcaaaaaagt tgaaaagcgt     3480

aaaagaactt cttggtatca caattatgga aagatcttca tttgaaaaaa atccaattga     3540

ctttttagaa gctaagggtt ataaagaagt taaaaaggat ttaatcataa aactaccaaa     3600

gtatagtcta tttgaactcg aaaacggaag aaaacgaatg ctcgctagcg caggagaact     3660

tcaaaaagga aatgaacttg cgctgccatc aaagtatgta aatttcttat atttagcttc     3720

tcattatgag aaattaaaag gatcaccaga ggataatgaa caaaagcaac tatttgtaga     3780

acaacacaaa cattatttag atgaaataat agaacaaata tctgaatttt ctaaaagagt     3840

tatacttgcc gacgcaaatc tagataaggt gctttcagcg tataataaac acagagataa     3900

accaataaga gaacaagcag aaaacattat ccatcttttt acattaacta atcttggtgc     3960

accagctgca tttaagtact ttgatacaac aatagataga aaaagataca catctactaa     4020

agaagtatta gacgcaactt taatacatca atctattaca gggctttatg aaacaagaat     4080

tgatttaagt caactaggcg gagattaagt cgacaaagta ttgttaaaaa taactctgta     4140

gaattataaa ttagttctac agagttattt tttgacccgg gtaccgagct cgaattcgta     4200

atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg ctcacaattc cacacaacat     4260

acgagccgga agcataaagt gtaaagcctg gggtgcctaa tgagtgagct aactcacatt     4320

aattgcgttg cgctcactgc ccgctttcca gtcgggaaac ctgtcgtgcc agctgcatta     4380

atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt gggcgctctt ccgcttcctc     4440

gctcactgac tcgctgcgct cggtcgttcg gctgcggcga gcggtatcag ctcactcaaa     4500

ggcggtaata cggttatcca cagaatcagg ggataacgca ggaaagaaca tgtgagcaaa     4560

aggccagcaa aaggccagga accgtaaaaa ggccgcgttg ctggcgtttt tccataggct     4620

ccgcccccct gacgagcatc acaaaaatcg acgctcaagt cagaggtggc gaaacccgac     4680

aggactataa agataccagg cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc     4740

gaccctgccg cttaccggat acctgtccgc ctttctccct tcgggaagcg tggcgctttc     4800

tcatagctca cgctgtaggt atctcagttc ggtgtaggtc gttcgctcca agctgggctg     4860

tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta tccggtaact atcgtcttga     4920

gtccaacccg gtaagacacg acttatcgcc actggcagca gccactggta acaggattag     4980

cagagcgagg tatgtaggcg gtgctacaga gttcttgaag tggtggccta actacggcta     5040

cactagaagg acagtatttg gtatctgcgc tctgctgaag ccagttacct tcggaaaaag     5100

agttggtagc tcttgatccg gcaaacaaac caccgctggt agcggtggtt tttttgtttg     5160

caagcagcag attacgcgca gaaaaaaagg atctcaagaa gatcctttga tcttttctac     5220

ggggtctgac gctcagtgga acgaaaactc acgttaaggg attttggtca tgagattatc     5280

aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga agttttaaat caatctaaag     5340

tatatatgag taaacttggt ctgacagtta ccaatgctta atcagtgagg cacctatctc     5400

agcgatctgt ctatttcgtt catccatagt tgcctgactc cccgtcgtgt agataactac     5460

gatacgggag ggcttaccat ctggccccag tgctgcaatg ataccgcgag acccacgctc     5520

accggctcca gatttatcag caataaacca gccagccgga agggccgagc gcagaagtgg     5580

tcctgcaact ttatccgcct ccatccagtc tattaattgt tgccgggaag ctagagtaag     5640

tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc     5700

acgctcgtcg tttggtatgg cttcattcag ctccggttcc caacgatcaa ggcgagttac     5760

atgatccccc atgttgtgca aaaaagcggt tagctccttc ggtcctccga tcgttgtcag     5820

aagtaagttg gccgcagtgt tatcactcat ggttatggca gcactgcata attctcttac     5880

tgtcatgcca tccgtaagat gcttttctgt gactggtgag tactcaacca agtcattctg     5940

agaatagtgt atgcggcgac cgagttgctc ttgcccggcg tcaatacggg ataataccgc     6000

gccacatagc agaactttaa aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact     6060

ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa cccactcgtg cacccaactg     6120

atcttcagca tcttttactt tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa     6180

tgccgcaaaa aagggaataa gggcgacacg gaaatgttga atactcatac tcttcctttt     6240

tcaatattat tgaagcattt atcagggtta ttgtctcatg agcggataca tatttgaatg     6300

tatttagaaa aataaacaaa taggggttcc gcgcacattt ccccgaaaag tgccacctga     6360

ctgccgggcc tcttgcggga tcaaaagaaa aacgaaatga tacaccaatc agtgcaaaaa     6420

aagatataat gggagataag acggttcgtg ttcgtgctga cttgcaccat atcataaaaa     6480

tcgaaacagc aaagaatggc ggaaacgtaa aagaagttat ggaaataaga cttagaagca     6540

aacttaagag tgtgttgata gtgcagtatc ttaaaatttt gtataatagg aattgaagtt     6600

aaattagatg ctaaaaattt gtaattaaga aggagtgatt acatgaacaa aaatataaaa     6660

tattctcaaa actttttaac gagtgaaaaa gtactcaacc aaataataaa acaattgaat     6720

ttaaaagaaa ccgataccgt ttacgaaatt ggaacaggta aagggcattt aacgacgaaa     6780

ctggctaaaa taagtaaaca ggtaacgtct attgaattag acagtcatct attcaactta     6840

tcgtcagaaa aattaaaact gaatactcgt gtcactttaa ttcaccaaga tattctacag     6900

tttcaattcc ctaacaaaca gaggtataaa attgttggga gtattcctta ccatttaagc     6960

acacaaatta ttaaaaaagt ggtttttgaa agccatgcgt ctgacatcta tctgattgtt     7020

gaagaaggat tctacaagcg taccttggat attcaccgaa cactagggtt gctcttgcac     7080

actcaagtct cgattcagca attgcttaag ctgccagcgg aatgctttca tcctaaacca     7140

aaagtaaaca gtgtcttaat aaaacttacc cgccatacca cagatgttcc agataaatat     7200

tggaagctat atacgtactt tgtttcaaaa tgggtcaatc gagaatatcg tcaactgttt     7260

actaaaaatc agtttcatca agcaatgaaa cacgccaaag taaacaattt aagtaccgtt     7320

acttatgagc aagtattgtc tatttttaat agttatctat tatttaacgg gaggaaataa     7380

ttctatgagt ccctaggccc aactaactca acgctagtag tggatttaat cccaaatgag     7440

ccaacagaac cagaaccaga aacagaatca gaacaagtaa cattggattt agaaatggaa     7500

gaagaaaaaa gcaatgactt cgtgtgaata atgcacgaaa tcgttgctta ttttttttta     7560

aaagcggtat actagatata acgaaacaac gaactgaata gaaacgaaaa aagagccatg     7620

acacatttat aaaatgtttg acgacatttt ataaatgcat agcccgataa gattgccaaa     7680

ccaacgctta tcagttagtc agatgaactc ttccctcgta agaagttatt taattaactt     7740

tgtttgaaga cggtatataa ccgtactatc attatatagg gaaatcagag agttttcaag     7800

tatctaagct actgaattta agaattgtta agcaatcaat cggaaatcgt ttgattgctt     7860

tttttgtatt catttataga aggtggagtt tgtatgaatc atgatgaatg taaaacttat     7920

ataaaaaata gtttattgga gataagaaaa ttagcaaata tctatacact agaaacgttt     7980

aagaaagagt tagaaaagag aaatatctac ttagaaacaa aatcagataa gtatttttct     8040

tcggaggggg aagattatat atataagtta atagaaaata acaaaataat ttattcgatt     8100

agtggaaaaa aattgactta taaaggaaaa aaatcttttt caaaacatgc aatattgaaa     8160

cagttgaatg aaaaagcaaa ccaagttaat taaacaacct attttatagg atttatagga     8220

aaggagaaca gctgaatgaa tatccctttt gttgtagaaa ctgtgcttca tgacggcttg     8280

ttaaagtaca aatttaaaaa tagtaaaatt cgctcaatca ctaccaagcc aggtaaaagc     8340

aaaggggcta tttttgcgta tcgctcaaaa tcaagcatga ttggcggtcg tggtgttgtt     8400

ctgacttccg aggaagcgat tcaagaaaat caagatacat ttacacattg gacacccaac     8460

gtttatcgtt atggaacgta tgcagacgaa aaccgttcat acacgaaagg acattctgaa     8520

aacaatttaa gacaaatcaa taccttcttt attgattttg atattcacac ggcaaaagaa     8580

actatttcag caagcgatat tttaacaacc gctattgatt taggttttat gcctactatg     8640

attatcaaat ctgataaagg ttatcaagca tattttgttt tagaaacgcc agtctatgtg     8700

acttcaaaat cagaatttaa atctgtcaaa gcagccaaaa taatttcgca aaatatccga     8760

gaatattttg gaaagtcttt gccagttgat ctaacgtgta atcattttgg tattgctcgc     8820

ataccaagaa cggacaatgt agaatttttt gatcctaatt accgttattc tttcaaagaa     8880

tggcaagatt ggtctttcaa acaaacagat aataagggct ttactcgttc aagtctaacg     8940

gttttaagcg gtacagaagg caaaaaacaa gtagatgaac cctggtttaa tctcttattg     9000

cacgaaacga aattttcagg agaaaagggt ttaatagggc gtaataacgt catgtttacc     9060

ctctctttag cctactttag ttcaggctat tcaatcgaaa cgtgcgaata taatatgttt     9120

gagtttaata atcgattaga tcaaccctta gaagaaaaag aagtaatcaa aattgttaga     9180

agtgcctatt cagaaaacta tcaaggggct aatagggaat acattaccat tctttgcaaa     9240

gcttgggtat caagtgattt aaccagtaaa gatttatttg tccgtcaagg gtggtttaaa     9300

ttcaagaaaa aaagaagcga acgtcaacgt gttcatttgt cagaatggaa agaagattta     9360

atggcttata ttagcgaaaa aagcgatgta tacaagcctt atttagtgac gaccaaaaaa     9420

gagattagag aagtgctagg cattcctgaa cggacattag ataaattgct gaaggtactg     9480

aaggcgaatc aggaaatttt ctttaagatt aaaccaggaa gaaatggtgg cattcaactt     9540

gctagtgtta aatcattgtt gctatcgatc attaaagtaa aaaaagaaga aaaagaaagc     9600

tatataaagg cgctgacaaa ttcttttgac ttagagcata cattcattca agagacttta     9660

aacaagctag cagaacgccc taaaacggac acacaactcg atttgtttag ctatgataca     9720

ggctgaaaat aaaacccgca ctatgccatt acatttatat ctatgatacg tgtttgtttt     9780

ttctttgctg tttagcgaat gattagcaga aatatacaga gtaagatttt aattaattat     9840

tagggggaga aggagagagt agcccgaaaa cttttagttg gcttggactg aacgaagtga     9900

gggaaaggct actaaaacgt cgaggggcag tgagagcgaa gcgaacactt gattttttaa     9960

ttttctatct tttataggtc attagagtat acttatttgt cctataaact atttagcagc    10020

ataatagatt tattgaatag gtcatttaag ttgagcatat tagaggagga aaatcttgga    10080

gaaatatttg aagaacccga ttacatggat tggattagtt cttgtggtta cgtggttttt    10140

aactaaaagt agtgaatttt tgatttttgg tgtgtgtgtc ttgttgttag tatttgctag    10200

tcaaagtgat taaatagaat tctagcgcca ttcgccattc aggctgcgca actgttggga    10260

agggcgatcg gtgcgggcct cttcgctatt acgccagctg gcgaaagggg gatgtgctgc    10320

aaggcgatta agttgggtaa cgccagggtt ttcccagtca cgacgttgta aaacgacggc    10380

cagtgccaag cttgcatgcc tgcaggcctc gagtatattg ataaaaataa taatagtggg    10440

tataattaag ttgttaggag gttagttac                                      10469


<210>  134
<211>  8559
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pMAD7

<400>  134
tcgagtccct atcagtgata gattgaaact ctatcattga tagagtataa tatctttgtt       60

cattagagcg ataaacttga atttgagagg gaacttagat gaacaacggc acaaataatt      120

ttcagaactt catagggata tcaagtttgc agaaaacgtt aagaaatgct ttaataccca      180

cggaaaccac gcaacagttc atagttaaga acggaataat taaagaagat gagttaagag      240

gcgagaacag acagatttta aaagatataa tggatgacta ctacagagga ttcatatctg      300

agactttaag ttctattgat gacatagatt ggactagctt attcgaaaaa atggaaattc      360

agttaaaaaa tggtgataat aaagatacct taattaagga acagacagag tatagaaaag      420

caatacataa aaaatttgcg aacgacgata gatttaagaa catgtttagc gccaaattaa      480

ttagtgacat attacctgaa tttgttatac acaacaataa ttattcggca tcagagaaag      540

aggaaaaaac ccaggtgata aaattgtttt cgagatttgc gactagcttt aaagattact      600

tcaagaacag agcaaattgc ttttcagcgg acgatatttc atcaagcagc tgccatagaa      660

tagttaacga caatgcagag atattctttt caaatgcgtt agtttacaga agaatagtaa      720

aatcgttaag caatgacgat ataaacaaaa tttcgggcga tatgaaagat tcattaaaag      780

aaatgagttt agaagaaata tattcttacg agaagtatgg ggaatttatt acccaggaag      840

gcattagctt ctataatgat atatgtggga aagtgaattc ttttatgaac ttatattgtc      900

agaaaaataa agaaaacaaa aatttataca aacttcagaa acttcacaaa cagattctat      960

gcattgcgga cactagctat gaggttccgt ataaatttga aagtgacgag gaagtgtacc     1020

aatcagttaa cggcttcctt gataacatta gcagcaaaca tatagttgaa agattaagaa     1080

aaataggcga taactataac ggctacaact tagataaaat ttatatagtg tccaaatttt     1140

acgagagcgt tagccaaaaa acctacagag actgggaaac aattaatacc gccttagaaa     1200

ttcattacaa taatatattg ccgggtaacg gtaaaagtaa agccgacaaa gtaaaaaaag     1260

cggttaagaa tgatttacag aaatccataa ccgaaataaa tgaactagtg tcaaactata     1320

agttatgcag tgacgacaac ataaaagcgg agacttatat acatgagatt agccatatat     1380

tgaataactt tgaagcacag gaattgaaat acaatccgga aattcaccta gttgaatccg     1440

agttaaaagc gagtgagctt aaaaacgtgt tagacgtgat aatgaatgcg tttcattggt     1500

gttcggtttt tatgactgag gaacttgttg ataaagacaa caatttttat gcggaattag     1560

aggagattta cgatgaaatt tatccagtaa ttagtttata caacttagtt agaaactacg     1620

ttacccagaa accgtacagc acgaaaaaga ttaaattgaa ctttggaata ccgacgttag     1680

cagacggttg gtcaaagtcc aaagagtatt ctaataacgc tataatatta atgagagaca     1740

atttatatta tttaggcata tttaatgcga agaataaacc ggacaagaag attatagagg     1800

gtaatacgtc agaaaataag ggtgactaca aaaagatgat ttataatttg ttaccgggtc     1860

ccaacaaaat gataccgaaa gttttcttga gcagcaagac gggggtggaa acgtataaac     1920

cgagcgccta tatactagag gggtataaac agaataaaca tataaagtct tcaaaagact     1980

ttgatataac tttctgtcat gatttaatag actacttcaa aaactgtatt gcaattcatc     2040

ccgagtggaa aaacttcggt tttgatttta gcgacaccag tacttatgaa gacatttccg     2100

ggttttatag agaggtagag ttacaaggtt acaagattga ttggacatac attagcgaaa     2160

aagacattga tttattacag gaaaaaggtc aattatattt attccagata tataacaaag     2220

atttttcgaa aaaatcaacc gggaatgaca accttcacac catgtactta aaaaatcttt     2280

tctcagaaga aaatcttaag gatatagttt taaaacttaa cggcgaagcg gaaatattct     2340

tcaggaagag cagcataaag aacccaataa ttcataaaaa aggctcgatt ttagttaaca     2400

gaacctacga agcagaagaa aaagaccagt ttggcaacat tcaaattgtg agaaaaaata     2460

ttccggaaaa catttatcag gagttataca aatacttcaa cgataaaagc gacaaagagt     2520

tatctgatga agcagccaaa ttaaagaatg tagtgggaca ccacgaggca gcgacgaata     2580

tagttaagga ctatagatac acgtatgata aatacttcct tcatatgcct attacgataa     2640

atttcaaagc caataaaacg ggttttatta atgataggat attacagtat atagctaaag     2700

aaaaagactt acatgtgata ggcattgata gaggcgagag aaacttaata tacgtgtccg     2760

tgattgatac ttgtggtaat atagttgaac agaaaagctt taacattgta aacggctacg     2820

actatcagat aaaattaaaa caacaggagg gcgctagaca gattgcgaga aaagaatgga     2880

aagaaattgg taaaattaaa gagataaaag agggctactt aagcttagta atacacgaga     2940

tatctaaaat ggtaataaaa tacaatgcaa ttatagcgat ggaggatttg tcttatggtt     3000

ttaaaaaagg gagatttaag gttgaaagac aagtttacca gaaatttgaa accatgttaa     3060

taaataaatt aaactattta gtatttaaag atatttcgat taccgagaat ggcggtttat     3120

taaaaggtta tcagttaaca tacattcctg ataaacttaa aaacgtgggt catcagtgcg     3180

gctgcatttt ttatgtgcct gctgcataca cgagcaaaat tgatccgacc accggctttg     3240

tgaatatatt taaatttaaa gacttaacag tggacgcaaa aagagaattc attaaaaaat     3300

ttgactcaat tagatatgac agtgaaaaaa atttattctg ctttacattt gactacaata     3360

actttattac gcaaaacacg gttatgagca aatcatcgtg gagtgtgtat acatacggcg     3420

tgagaataaa aagaagattt gtgaacggca gattctcaaa cgaaagtgat accattgaca     3480

taaccaaaga tatggagaaa acgttggaaa tgacggacat taactggaga gatggccacg     3540

atcttagaca agacattata gattatgaaa ttgttcagca catattcgaa attttcagat     3600

taacagtgca aatgagaaac tccttgtctg aattagagga cagagattac gatagattaa     3660

tttcacctgt attaaacgaa aataacattt tttatgacag cgcgaaagcg ggggatgcac     3720

ttcctaagga tgccgatgca aatggtgcgt attgtattgc attaaaaggg ttatatgaaa     3780

ttaaacaaat taccgaaaat tggaaagaag atggtaaatt ttcgagagat aaattaaaaa     3840

taagcaataa agattggttc gactttatac agaataagag atatttataa gtcgacaaag     3900

tattgttaaa aataactctg tagaattata aattagttct acagagttat tttttgaccc     3960

gggtatattg ataaaaataa taatagtggg tataattaag ttgttaggag gttagttaga     4020

atgatgtcaa gattagataa aagtaaagtg attaacagcg cattagagct gcttaatgag     4080

gtcggaatcg aaggtttaac aacccgtaaa ctcgcccaga agctaggtgt agagcagcct     4140

acattgtatt ggcatgtaaa aaataagcgg gctttgctcg acgccttagc cattgagatg     4200

ttagataggc accatactca cttttgccct ttagaagggg aaagctggca agatttttta     4260

cgtaataacg ctaaaagttt tagatgtgct ttactaagtc atcgcgatgg agcaaaagta     4320

catttaggta cacggcctac agaaaaacag tatgaaactc tcgaaaatca attagccttt     4380

ttatgccaac aaggtttttc actagagaat gcattatatg cactcagcgc tgtggggcat     4440

tttactttag gttgcgtatt ggaagatcaa gagcatcaag tcgctaaaga agaaagggaa     4500

acacctacta ctgatagtat gccgccatta ttacgacaag ctatcgaatt atttgatcac     4560

caaggtgcag agccagcctt cttattcggc cttgaattga tcatatgcgg attagaaaaa     4620

caacttaaat gtgaaagtgg gtcttaaaag cagcataacc tttttccgtg atggtaactt     4680

cacggtaacc aagatgtcga gttgagctcg aattcgtaat catggtcata gctgtttcct     4740

gtgtgaaatt gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt     4800

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc     4860

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg     4920

agaggcggtt tgcgtattgg gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg     4980

gtcgttcggc tgcggcgagc ggtatcagct cactcaaagg cggtaatacg gttatccaca     5040

gaatcagggg ataacgcagg aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac     5100

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     5160

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     5220

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     5280

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     5340

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     5400

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     5460

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     5520

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaaggac agtatttggt     5580

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     5640

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     5700

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     5760

gaaaactcac gttaagggat tttggtcatg agattatcaa aaaggatctt cacctagatc     5820

cttttaaatt aaaaatgaag ttttaaatca atctaaagta tatatgagta aacttggtct     5880

gacagttacc aggtccactg ccgggcctct tgcgggatca aaagaaaaac gaaatgatac     5940

accaatcagt gcaaaaaaag atataatggg agataagacg gttcgtgttc gtgctgactt     6000

gcaccatatc ataaaaatcg aaacagcaaa gaatggcgga aacgtaaaag aagttatgga     6060

aataagactt agaagcaaac ttaagagtgt gttgatagtg cagtatctta aaattttgta     6120

taataggaat tgaagttaaa ttagatgcta aaaatttgta attaagaagg agtgattaca     6180

tgaacaaaaa tataaaatat tctcaaaact ttttaacgag tgaaaaagta ctcaaccaaa     6240

taataaaaca attgaattta aaagaaaccg ataccgttta cgaaattgga acaggtaaag     6300

ggcatttaac gacgaaactg gctaaaataa gtaaacaggt aacgtctatt gaattagaca     6360

gtcatctatt caacttatcg tcagaaaaat taaaactgaa tactcgtgtc actttaattc     6420

accaagatat tctacagttt caattcccta acaaacagag gtataaaatt gttgggagta     6480

ttccttacca tttaagcaca caaattatta aaaaagtggt ttttgaaagc catgcgtctg     6540

acatctatct gattgttgaa gaaggattct acaagcgtac cttggatatt caccgaacac     6600

tagggttgct cttgcacact caagtctcga ttcagcaatt gcttaagctg ccagcggaat     6660

gctttcatcc taaaccaaaa gtaaacagtg tcttaataaa acttacccgc cataccacag     6720

atgttccaga taaatattgg aagctatata cgtactttgt ttcaaaatgg gtcaatcgag     6780

aatatcgtca actgtttact aaaaatcagt ttcatcaagc aatgaaacac gccaaagtaa     6840

acaatttaag taccgttact tatgagcaag tattgtctat ttttaatagt tatctattat     6900

ttaacgggag gaaataattc tatgagtccc taggcaggcc tccgccatta tttttttgaa     6960

caattgacaa ttcatttctt attttttatt aagtgatagt caaaaggcat aacagtgctg     7020

aatagaaaga aatttacaga aaagaaaatt atagaattta gtatgattaa ttatactcat     7080

ttatgaatgt ttaattgaat acaaaaaaaa atacttgtta tgtattcaat tacgggttaa     7140

aatatagaca agttgaaaaa tttaataaaa aaataagtcc tcagctctta tatattaagc     7200

taccaactta gtatataagc caaaacttaa atgtgctacc aacacatcaa gccgttagag     7260

aactctatct atagcaatat ttcaaatgta ccgacataca agagaaacat taactatata     7320

tattcaattt atgagattat cttaacagat ataaatgtaa attgcaataa gtaagattta     7380

gaagtttata gcctttgtgt attggaagca gtacgcaaag gcttttttat ttgataaaaa     7440

ttagaagtat atttattttt tcataattaa tttatgaaaa tgaaaggggg tgagcaaagt     7500

gacagaggaa agcagtatct tatcaaataa caaggtatta gcaatatcat tattgacttt     7560

agcagtaaac attatgactt ttatagtgct tgtagctaag tagtacgaaa gggggagctt     7620

taaaaagctc cttggaatac atagaattca taaattaatt tatgaaaaga agggcgtata     7680

tgaaaacttg taaaaattgc aaagagttta ttaaagatac tgaaatatgc aaaatacatt     7740

cgttgatgat tcatgataaa acagtagcaa cctattgcag taaatacaat gagtcaagat     7800

gtttacataa agggaaagtc caatgtatta attgttcaaa gatgaaccga tatggatggt     7860

gtgccataaa aatgagatgt tttacagagg aagaacagaa aaaagaacgt acatgcatta     7920

aatattatgc aaggagcttt aaaaaagctc atgtaaagaa gagtaaaaag aaaaaataat     7980

ttatttatta atttaatatt gagagtgccg acacagtatg cactaaaaaa tatatctgtg     8040

gtgtagtgag ccgatacaaa aggatagtca ctcgcatttt cataatacat cttatgttat     8100

gattatgtgt cggtgggact tcacgacgaa aacccacaat aaaaaaagag ttcggggtag     8160

ggttaagcat agttgaggca actaaacaat caagctagga tatgcagtag cagaccgtaa     8220

ggtcgttgtt taggtgtgtt gtaatacata cgctattaag atgtaaaaat acggatacca     8280

atgaagggaa aagtataatt tttggatgta gtttgtttgt tcatctatgg gcaaactacg     8340

tccaaagccg tttccaaatc tgctaaaaag tatatccttt ctaaaatcaa agtcaagtat     8400

gaaatcataa ataaagttta attttgaagt tattatgata ttatgttttt ctattaaaat     8460

aaattaagta tatagaatag tttaataata gtatatactt aatgtgataa gtgtctgaca     8520

gtgtcacaga aaggatgatt gttatggatt ataagcggc                            8559


