               SEQUENCE LISTING

<110> Université de Paris 
      Centre National de la Recherche Scientifique (CNRS)
      ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (AP-HP)
      INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

<120> DETECTION OF HYPERMETHYLATED GENES FOR DIAGNOSING PANCREATIC CANCER

<130> 0698-IDF26-EP-PC

<150> EP19305695.9
<151> 2019-05-29

<160> 10

<170> BiSSAP 1.3.6

<210> 1
<211> 1001
<212> DNA
<213> Homo sapiens


<220> 
<223> POU4F1 chr13: 79176072-79177072

<400> 1
cgccgccgat gccgctgcca cctgcccggc cgccgccgcc gccgctgccg ctgccgcgcc      60

gtggtgcgcc gccgccgcca ccagcccggg gtgcggcagc ccggacggca tgttcatggc     120

ggccgccgcc gcggggtgcg acaggtggcc caggctgtgc atatgcgggt gagggtgcgc     180

ggagccgccc aggagcccgc cgcccgggcc gccgccgccg ccccccgggc cgccaccgcc     240

gcctcccccg gggccgccgc ccgggccgcc gccgccgccc gggccgccac cgccccccgg     300

gccgtcgtgg gcgccgccgc cgccggccgc cgcgcccgcg ccgcccgcgc cggccatgag     360

cgcgagcgac ggcgaggaga tgtggtccag cagatcgccg ggttcgagcg cctggtggtg     420

gtggtggtgg tggtggtggt gcgccagagg caccgtggaa gtggacgtgc acggcacgct     480

gttcatcgtg tggtacgtgg cgtccggctt gaaaggatgg ctcttgccct gggacacggc     540

gatgtccacg gccgccagcg cctcggcccg cgccagcagc gtctcgtcca ggctggcgaa     600

gaggttgctc tgcagctgca ggcgacacaa accaaaccaa aaaaaccaca aaaccaaaag     660

agcaaaacaa aacaacagaa gaaacacaca cacaggccgg aaagcacagc atgcgaaggg     720

caaacacaaa gcaaccaaaa taacaacggg tttgggggca gtggagagcg ggaaagacgg     780

agagggggca cattgacgac cagggagggg gcagacgaga agggatggga gcgtggagag     840

ggggacagaa gtagggagaa agggggacac aagaacacat tccggaaacg ggcgtgggag     900

acgaaaaaga gggaaaagaa gaaatggaaa tgtaactcgc agctggggac ccgtgtcaca     960

cacccgagca cgcacagaga ctgcctttct gaggcgtgaa a                        1001


<210> 2
<211> 201
<212> DNA
<213> Homo sapiens


<220> 
<223> POU4F1 chr13: 79176472-79176672

<400> 2
ggttcgagcg cctggtggtg gtggtggtgg tggtggtggt gcgccagagg caccgtggaa     60

gtggacgtgc acggcacgct gttcatcgtg tggtacgtgg cgtccggctt gaaaggatgg    120

ctcttgccct gggacacggc gatgtccacg gccgccagcg cctcggcccg cgccagcagc    180

gtctcgtcca ggctggcgaa g                                              201


<210> 3
<211> 1026
<212> DNA
<213> Homo sapiens


<220> 
<223> HOXD8 chr2: 176994063-176995088

<400> 3
accacttcga tatgccccaa ctcaaatgca cggtccggtc cgtcaacacc tcttgtccac      60

gttccctggg ctgcacccgc gtgtccagag ctgcaaaagc cacgggcaac ctctgctttt     120

gcagccaggg gctcggggag gcagtcattt gctccgcagc ctcctgggag tggcctcctt     180

ggctccccca agtctaaggc tccgccgcgg cccctccctg ccggctgcga tccgcattcc     240

cgcggccccg gggcacacgg agcccttggc agtgcgtctt tatgggcccc ctttaaggcc     300

ggcggaggca tctcgggccg ggcgcggcgc tccgtccgtc ggccgtagcg actgaactgc     360

gcgcggatcc ctccgcgggg ctcctcgtcc ccgtcacgct gactttccgt gcagtgctgt     420

ggtgcgaaaa tgcctcgccg gtgcgcaccg ggtcggcagc ctcggcggcg ggggcgagat     480

tggcgggagg ggggcgcggg gggggcgcgg taagaggtgg cggcgggcag agggtgtttt     540

ttttcttttc cctccagagc cggggtttgt aaaccgaggc cagagtgtcc ccgtgggccg     600

agcgcacttt tttcttgtcc gggtgcgctc agtcactggt gcctgagagg aaacagtgga     660

ggcagcgggg caggtcgcct ggggcgtcgg cgattatatt gcggccgagc cggggcgcgc     720

cgggaaaggc cgggagggcg gcggcgcgcg ggggctgggc gaggccccgc gacccgcgag     780

ggaggcggcg cgaagccgag gcggcgggcg caagagccgg gcatgagcgc ccagtagctg     840

agcgcccgcg gctgcctggc ctcagaagcg acgcgcgagc gcgggcgggc ggcagcagcg     900

acgtagcccg gcggtcccgg cggcgagagc agccgcccca caggcccccg cggcagtgcg     960

gccgagtcga ggctcgctct ctggctgctt agcgccgccc gcccgcccgg ggccgccgcc    1020

gctgac                                                               1026


<210> 4
<211> 726
<212> DNA
<213> Homo sapiens


<220> 
<223> HOXD8 chr2: 176994363-176995088

<400> 4
ggcggaggca tctcgggccg ggcgcggcgc tccgtccgtc ggccgtagcg actgaactgc      60

gcgcggatcc ctccgcgggg ctcctcgtcc ccgtcacgct gactttccgt gcagtgctgt     120

ggtgcgaaaa tgcctcgccg gtgcgcaccg ggtcggcagc ctcggcggcg ggggcgagat     180

tggcgggagg ggggcgcggg gggggcgcgg taagaggtgg cggcgggcag agggtgtttt     240

ttttcttttc cctccagagc cggggtttgt aaaccgaggc cagagtgtcc ccgtgggccg     300

agcgcacttt tttcttgtcc gggtgcgctc agtcactggt gcctgagagg aaacagtgga     360

ggcagcgggg caggtcgcct ggggcgtcgg cgattatatt gcggccgagc cggggcgcgc     420

cgggaaaggc cgggagggcg gcggcgcgcg ggggctgggc gaggccccgc gacccgcgag     480

ggaggcggcg cgaagccgag gcggcgggcg caagagccgg gcatgagcgc ccagtagctg     540

agcgcccgcg gctgcctggc ctcagaagcg acgcgcgagc gcgggcgggc ggcagcagcg     600

acgtagcccg gcggtcccgg cggcgagagc agccgcccca caggcccccg cggcagtgcg     660

gccgagtcga ggctcgctct ctggctgctt agcgccgccc gcccgcccgg ggccgccgcc     720

gctgac                                                                726


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Forward Primer POU4F1

<400> 5
tggtgcgtta gaggtatcgt                                                20


<210> 6
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Reverse Primer POU4F1

<400> 6
aaaccatcct ttcaaaccga                                                20


<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Forward Primer HOXD8

<400> 7
agagtcgggg tttgtaaatc g                                              21


<210> 8
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Reverse Primer HOXD8

<400> 8
ctctcaaaca ccaataacta aacg                                           24


<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Probe POU4F1: FAM - SEQ ID NO:9 -MGB - NFQ

<400> 9
caacgtaccg tacacgtcca                                                20


<210> 10
<211> 16
<212> DNA
<213> Artificial Sequence


<220> 
<223> Probe HOXD8: FAM - SEQ ID NO:10 -MGB - NFQ

<400> 10
tcgtgggtcg agcgta                                                    16


