               SEQUENCE LISTING

<110> UNIVERSITÉ DE TOURS
      KYMERIS THERAPEUTICS INC.

<120> TOXOPLASMA PLATEFORME FOR TREATING CANCER

<130> CV-981/PCT

<150> EP19305686.8
<151> 2019-05-29

<160> 57

<170> BiSSAP 1.3.6

<210> 1
<211> 633
<212> RNA
<213> Artificial Sequence


<220> 
<223> IL15RA+LINKER+IL15

<400> 1
attacgtgcc cgccaccgat gtctgtcgag cacgcagata tttgggttaa atcctacagt      60

ctgtactccc gtgagcggta catctgtaat tcggggttca aacggaaggc tggtacctcg     120

tcgctgacag aatgtgtgct caataaggca accaacgtgg cccactggac aaccccatcg     180

ctcaagtgca tcagggaccc tgctctcgtt catcagcgcc ccgcaccacc ttccggcggg     240

tcgggaggcg gcggaagtgg aggcggttct ggaggtggtg gctcgctgca aaactgggtg     300

aatgtgattt ccgatctcaa gaaaattgag gaccttatcc agtctatgca catcgatgcg     360

acactgtaca cggagtcgga cgtccaccct tcttgcaaag tgactgctat gaagtgcttc     420

ttgttggagt tgcaagtgat cagccttgaa tcgggtgacg cttctattca cgataccgtc     480

gaaaacctga tcatcctcgc taataactcg ctttcctcta atggtaatgt taccgagtcc     540

ggctgtaagg aatgcgagga actcgaagag aagaacatta aggagttcct ccagagcttt     600

gttcatatcg ttcaaatgtt catcaacacg tcc                                  633


<210> 2
<211> 211
<212> PRT
<213> Artificial Sequence


<220> 
<223> IL15RA+LINKER+IL15

<400> 2
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      
Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          
Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              
Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  
Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Gly Gly 
65                  70                  75                  80  
Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu 
                85                  90                  95      
Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu 
            100                 105                 110         
Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val 
        115                 120                 125             
His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu 
    130                 135                 140                 
Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val 
145                 150                 155                 160 
Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn 
                165                 170                 175     
Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn 
            180                 185                 190         
Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile 
        195                 200                 205             
Asn Thr Ser 
    210     

<210> 3
<211> 231
<212> RNA
<213> Homo sapiens


<220> 
<223> IL15RA

<400> 3
atcacgtgcc ctccccccat gtccgtggaa cacgcagaca tctgggtcaa gagctacagc     60

ttgtactcca gggagcggta catttgtaac tctggtttca agcgtaaagc cggcacgtcc    120

agcctgacgg agtgcgtgtt gaacaaggcc acgaatgtcg cccactggac aacccccagt    180

ctcaaatgca ttagagaccc tgccctggtt caccaaaggc cagcgccacc c             231


<210> 4
<211> 77
<212> PRT
<213> Homo sapiens


<220> 
<223> IL15RA

<400> 4
Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp Val 
1               5                   10                  15      
Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser Gly 
            20                  25                  30          
Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu Asn 
        35                  40                  45              
Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys Ile 
    50                  55                  60                  
Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro 
65                  70                  75          

<210> 5
<211> 342
<212> RNA
<213> Homo sapiens


<220> 
<223> IL15

<400> 5
aactgggtga atgtaataag tgatttgaaa aaaattgaag atcttattca atctatgcat      60

attgatgcta ctttatatac ggaaagtgat gttcacccca gttgcaaagt aacagcaatg     120

aagtgctttc tcttggagtt acaagttatt tcacttgagt ccggagatgc aagtattcat     180

gatacagtag aaaatctgat catcctagca aacaacagtt tgtcttctaa tgggaatgta     240

acagaatctg gatgcaaaga atgtgaggaa ctggaggaaa aaaatattaa agaatttttg     300

cagagttttg tacatattgt ccaaatgttc atcaacactt ct                        342


<210> 6
<211> 114
<212> PRT
<213> Homo sapiens


<220> 
<223> IL15

<400> 6
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      
Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          
Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              
Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  
Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  
Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      
Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         
Thr Ser 
        

<210> 7
<211> 60
<212> RNA
<213> Artificial Sequence


<220> 
<223> Linker

<400> 7
agtggaggca gcggaggcgg aggctccggc ggaggaagtg gaggcggagg cagtctgcag     60


<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 8
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      
Gly Ser Leu Gln 
            20  

<210> 9
<211> 66
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SUB1

<400> 9
gggtcatctc atgccattgt cgcgtgtgct gccttgatcg tgttgttatc caccaacgcg     60

agagga                                                                66


<210> 10
<211> 22
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SUB1

<400> 10
Gly Ser Ser His Ala Ile Val Ala Cys Ala Ala Leu Ile Val Leu Leu 
1               5                   10                  15      
Ser Thr Asn Ala Arg Gly 
            20          

<210> 11
<211> 585
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SUB1 propeptide

<400> 11
ctcagggtgc ggaaagacaa agacgtactg ttggcaacga gttttctttc ccaccatgga      60

gaatatcaga atcccactgg cacatataac cttatcaagg agattcggag ggtggaagcg     120

gaaatcgaag atgaggttga aacactaaac agagacagaa ggctgcatcg tgggcacaac     180

aaatatgccg atgacgacat ccgacagggg ctaaagggcg agcaagatat gggcgcttca     240

gaaaatattc ccgttgcgga gctcgaacca caggatttag atcgggaggc gaagtatcct     300

gtgcggatgt tgattgtgga caagcgttct gatgatgatg atgaagagac caaaacctcg     360

tttgtggaga cggcgctaca ttcggatctt gcgcaacgcg ttgtaaagga gctgaacggg     420

catgtggacg tccttagaga aagtggcgtg gttttagtgg atcttccagc acaaaccacc     480

gacaaacaac tgcaggaatt gatcgaaacc gccagggcac aaggcaccat agtagagccg     540

gatcacttgg ttcaaagtgt caatacatcg tcgaaaggat caaat                     585


<210> 12
<211> 195
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SUB1 propeptide

<400> 12
Leu Arg Val Arg Lys Asp Lys Asp Val Leu Leu Ala Thr Ser Phe Leu 
1               5                   10                  15      
Ser His His Gly Glu Tyr Gln Asn Pro Thr Gly Thr Tyr Asn Leu Ile 
            20                  25                  30          
Lys Glu Ile Arg Arg Val Glu Ala Glu Ile Glu Asp Glu Val Glu Thr 
        35                  40                  45              
Leu Asn Arg Asp Arg Arg Leu His Arg Gly His Asn Lys Tyr Ala Asp 
    50                  55                  60                  
Asp Asp Ile Arg Gln Gly Leu Lys Gly Glu Gln Asp Met Gly Ala Ser 
65                  70                  75                  80  
Glu Asn Ile Pro Val Ala Glu Leu Glu Pro Gln Asp Leu Asp Arg Glu 
                85                  90                  95      
Ala Lys Tyr Pro Val Arg Met Leu Ile Val Asp Lys Arg Ser Asp Asp 
            100                 105                 110         
Asp Asp Glu Glu Thr Lys Thr Ser Phe Val Glu Thr Ala Leu His Ser 
        115                 120                 125             
Asp Leu Ala Gln Arg Val Val Lys Glu Leu Asn Gly His Val Asp Val 
    130                 135                 140                 
Leu Arg Glu Ser Gly Val Val Leu Val Asp Leu Pro Ala Gln Thr Thr 
145                 150                 155                 160 
Asp Lys Gln Leu Gln Glu Leu Ile Glu Thr Ala Arg Ala Gln Gly Thr 
                165                 170                 175     
Ile Val Glu Pro Asp His Leu Val Gln Ser Val Asn Thr Ser Ser Lys 
            180                 185                 190         
Gly Ser Asn 
        195 

<210> 13
<211> 84
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> MIC5 signal sequence

<400> 13
ctgcgaccta ctgttcgtag ctcgttactg tccctggggc tgacagtgat cctctatctg     60

gctcttaccg gctctgctga tgcg                                            84


<210> 14
<211> 28
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> MIC5 signal sequence

<400> 14
Leu Arg Pro Thr Val Arg Ser Ser Leu Leu Ser Leu Gly Leu Thr Val 
1               5                   10                  15      
Ile Leu Tyr Leu Ala Leu Thr Gly Ser Ala Asp Ala 
            20                  25              

<210> 15
<211> 54
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> MIC5 propeptide

<400> 15
ttagcctcgc atttacgctc cagacacatg gaagccggaa gacgaaccat ggat           54


<210> 16
<211> 18
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> MIC5 propeptide

<400> 16
Leu Ala Ser His Leu Arg Ser Arg His Met Glu Ala Gly Arg Arg Thr 
1               5                   10                  15      
Met Asp 
        

<210> 17
<211> 78
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> GPI anchor

<400> 17
gctgcgggaa cagccagtca cgtttccatt tttgccatgg tgatcggact tattggctct     60

atcgcagctt gtgtcgcg                                                   78


<210> 18
<211> 26
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> GPI anchor

<400> 18
Ala Ala Gly Thr Ala Ser His Val Ser Ile Phe Ala Met Val Ile Gly 
1               5                   10                  15      
Leu Ile Gly Ser Ile Ala Ala Cys Val Ala 
            20                  25      

<210> 19
<211> 738
<212> RNA
<213> Artificial Sequence


<220> 
<223> ScFv

<400> 19
caggtgcagc tgcaggagag tggcggagga ctggtgcagc caggcggaag tctgcgcctg      60

agttgcgccg ccagcggctt caccttcaac gatttctaca tgaactggat tcgccagccc     120

ccaggccagg ccccagagtg gctgggagtg attcgcaaca agggcaacgg ctacaccacc     180

gaagtgaaca ccagcgtgaa gggacgcttc accatcagcc gcgataacac ccagaacatc     240

ctgtacttgc agatgaacag cctgcgcgcc gaggataccg ccatctacta ttgcgcccgc     300

ggcggcccct actactacag cggagatgat gccccctact ggggccaggg cgtgatggtc     360

accgtgtcca gtggcggagg cggatccggc ggaggcggaa gcggaggcgg aggcagtgac     420

atccagatga cccagagccc cagttccctg agcgccagtg tgggagatcg cgtgaccatt     480

acctgccgcg cctcgcagaa catcaagggc tggctggcct ggtatcagca gaagtccgga     540

aacgcccccc agctgctgat ctacaaggcc agcagtttgc agagcggcgt gcccagccgc     600

tttagcggaa gtggaagcgg caccgattac atcttcacca ttagcaactt gcagcccgag     660

gacattgcca cctactactg ccagcactac cagagcttcc cgtggacctt cggcggaggt     720

accaagctgg agctgaag                                                   738


<210> 20
<211> 246
<212> PRT
<213> Artificial Sequence


<220> 
<223> ScFv

<400> 20
Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe 
            20                  25                  30          
Tyr Met Asn Trp Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu 
        35                  40                  45              
Gly Val Ile Arg Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro 
            100                 105                 110         
Tyr Trp Gly Gln Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 
    130                 135                 140                 
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 
Thr Cys Arg Ala Ser Gln Asn Ile Lys Gly Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     
Gln Lys Ser Gly Asn Ala Pro Gln Leu Leu Ile Tyr Lys Ala Ser Ser 
            180                 185                 190         
Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             
Asp Tyr Ile Phe Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr 
    210                 215                 220                 
Tyr Tyr Cys Gln His Tyr Gln Ser Phe Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 
Thr Lys Leu Glu Leu Lys 
                245     

<210> 21
<211> 99
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SAG1 Nterm

<400> 21
atgtttccga aggcagtgag acgcgccgtc acggcagggg tgtttgccgc gcccacactg     60

atgtcgttct tgcgatgtgg cgttatggca tcggatccc                            99


<210> 22
<211> 33
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SAG1 Nterm

<400> 22
Met Phe Pro Lys Ala Val Arg Arg Ala Val Thr Ala Gly Val Phe Ala 
1               5                   10                  15      
Ala Pro Thr Leu Met Ser Phe Leu Arg Cys Gly Val Met Ala Ser Asp 
            20                  25                  30          
Pro 
    

<210> 23
<211> 756
<212> RNA
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SAG1 without N terminal signal sequence

<400> 23
cctcttgttg ccaatcaagt tgtcacctgc ccagataaaa aatcgacagc cgcggtcatt      60

ctcacaccga cggagaacca cttcactctc aagtgcccta aaacagcgct cacagagcct     120

cccactcttg cgtactcacc caacaggcaa atctgcccag cgggtactac aagtagctgt     180

acatcaaagg ctgtaacatt gagctccttg attcctgaag cagaagatag ctggtggacg     240

ggggattctg ctagtctcga cacggcaggc atcaaactca cagttccaat cgagaagttc     300

cccgtgacaa cgcagacgtt tgtggtcggt tgcatcaagg gagacgacgc acagagttgt     360

atggtcacag tgacagtaca agccagagcc tcatcggtcg tcaataatgt cgcaaggtgc     420

tcctacggtg cagacagcac tcttggtcct gtcaagttgt ctgcggaagg acccactaca     480

atgaccctcg tgtgcgggaa agatggagtc aaagttcctc aagacaacaa tcagtactgt     540

tccgggacga cgctgactgg ttgcaacgag aaatcgttca aagatatttt gccaaaatta     600

actgagaacc cgtggcaggg taacgcttcg agtgataagg gtgccacgct aacgatcaag     660

aaggaagcat ttccagccga gtcaaaaagc gtcattattg gatgcacagg gggatcgcct     720

gagaagcatc actgtaccgt gaaactggag tttgcc                               756


<210> 24
<211> 252
<212> PRT
<213> Toxoplasma <Apicomplexa>


<220> 
<223> SAG1 without N terminal signal sequence

<400> 24
Pro Leu Val Ala Asn Gln Val Val Thr Cys Pro Asp Lys Lys Ser Thr 
1               5                   10                  15      
Ala Ala Val Ile Leu Thr Pro Thr Glu Asn His Phe Thr Leu Lys Cys 
            20                  25                  30          
Pro Lys Thr Ala Leu Thr Glu Pro Pro Thr Leu Ala Tyr Ser Pro Asn 
        35                  40                  45              
Arg Gln Ile Cys Pro Ala Gly Thr Thr Ser Ser Cys Thr Ser Lys Ala 
    50                  55                  60                  
Val Thr Leu Ser Ser Leu Ile Pro Glu Ala Glu Asp Ser Trp Trp Thr 
65                  70                  75                  80  
Gly Asp Ser Ala Ser Leu Asp Thr Ala Gly Ile Lys Leu Thr Val Pro 
                85                  90                  95      
Ile Glu Lys Phe Pro Val Thr Thr Gln Thr Phe Val Val Gly Cys Ile 
            100                 105                 110         
Lys Gly Asp Asp Ala Gln Ser Cys Met Val Thr Val Thr Val Gln Ala 
        115                 120                 125             
Arg Ala Ser Ser Val Val Asn Asn Val Ala Arg Cys Ser Tyr Gly Ala 
    130                 135                 140                 
Asp Ser Thr Leu Gly Pro Val Lys Leu Ser Ala Glu Gly Pro Thr Thr 
145                 150                 155                 160 
Met Thr Leu Val Cys Gly Lys Asp Gly Val Lys Val Pro Gln Asp Asn 
                165                 170                 175     
Asn Gln Tyr Cys Ser Gly Thr Thr Leu Thr Gly Cys Asn Glu Lys Ser 
            180                 185                 190         
Phe Lys Asp Ile Leu Pro Lys Leu Thr Glu Asn Pro Trp Gln Gly Asn 
        195                 200                 205             
Ala Ser Ser Asp Lys Gly Ala Thr Leu Thr Ile Lys Lys Glu Ala Phe 
    210                 215                 220                 
Pro Ala Glu Ser Lys Ser Val Ile Ile Gly Cys Thr Gly Gly Ser Pro 
225                 230                 235                 240 
Glu Lys His His Cys Thr Val Lys Leu Glu Phe Ala 
                245                 250         

<210> 25
<211> 27
<212> RNA
<213> Artificial Sequence


<220> 
<223> HA Tag

<400> 25
tacccatacg atgttccaga ttacgct                                        27


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> HA Tag

<400> 26
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   

<210> 27
<211> 15
<212> RNA
<213> Artificial Sequence


<220> 
<223> Linker

<400> 27
ggcggaggcg ctagc                                                     15


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Linker

<400> 28
Gly Gly Gly Ala Ser 
1               5   

<210> 29
<211> 295
<212> PRT
<213> Artificial Sequence


<220> 
<223> DC2

<400> 29
Met Phe Pro Lys Ala Val Arg Arg Ala Val Thr Ala Gly Val Phe Ala 
1               5                   10                  15      
Ala Pro Thr Leu Met Ser Phe Leu Arg Cys Gly Val Met Ala Ser Asp 
            20                  25                  30          
Pro Thr Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Val Gln Leu 
        35                  40                  45              
Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    50                  55                  60                  
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn Trp 
65                  70                  75                  80  
Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile Arg 
                85                  90                  95      
Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys Gly 
            100                 105                 110         
Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu Gln 
        115                 120                 125             
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    130                 135                 140                 
Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly Gln 
145                 150                 155                 160 
Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            180                 185                 190         
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        195                 200                 205             
Ser Gln Asn Ile Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly 
    210                 215                 220                 
Asn Ala Pro Gln Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly 
225                 230                 235                 240 
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe 
                245                 250                 255     
Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            260                 265                 270         
His Tyr Gln Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        275                 280                 285             
Leu Lys Gly Gly Gly Ala Ser 
    290                 295 

<210> 30
<211> 549
<212> PRT
<213> Artificial Sequence


<220> 
<223> DC2

<400> 30
Met Phe Pro Lys Ala Val Arg Arg Ala Val Thr Ala Gly Val Phe Ala 
1               5                   10                  15      
Ala Pro Thr Leu Met Ser Phe Leu Arg Cys Gly Val Met Ala Ser Asp 
            20                  25                  30          
Pro Thr Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Val Gln Leu 
        35                  40                  45              
Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    50                  55                  60                  
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn Trp 
65                  70                  75                  80  
Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile Arg 
                85                  90                  95      
Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys Gly 
            100                 105                 110         
Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu Gln 
        115                 120                 125             
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    130                 135                 140                 
Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly Gln 
145                 150                 155                 160 
Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            180                 185                 190         
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        195                 200                 205             
Ser Gln Asn Ile Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly 
    210                 215                 220                 
Asn Ala Pro Gln Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly 
225                 230                 235                 240 
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe 
                245                 250                 255     
Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            260                 265                 270         
His Tyr Gln Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        275                 280                 285             
Leu Lys Gly Gly Gly Ala Ser Ser Arg Pro Leu Val Ala Asn Gln Val 
    290                 295                 300                 
Val Thr Cys Pro Asp Lys Lys Ser Thr Ala Ala Val Ile Leu Thr Pro 
305                 310                 315                 320 
Thr Glu Asn His Phe Thr Leu Lys Cys Pro Lys Thr Ala Leu Thr Glu 
                325                 330                 335     
Pro Pro Thr Leu Ala Tyr Ser Pro Asn Arg Gln Ile Cys Pro Ala Gly 
            340                 345                 350         
Thr Thr Ser Ser Cys Thr Ser Lys Ala Val Thr Leu Ser Ser Leu Ile 
        355                 360                 365             
Pro Glu Ala Glu Asp Ser Trp Trp Thr Gly Asp Ser Ala Ser Leu Asp 
    370                 375                 380                 
Thr Ala Gly Ile Lys Leu Thr Val Pro Ile Glu Lys Phe Pro Val Thr 
385                 390                 395                 400 
Thr Gln Thr Phe Val Val Gly Cys Ile Lys Gly Asp Asp Ala Gln Ser 
                405                 410                 415     
Cys Met Val Thr Val Thr Val Gln Ala Arg Ala Ser Ser Val Val Asn 
            420                 425                 430         
Asn Val Ala Arg Cys Ser Tyr Gly Ala Asp Ser Thr Leu Gly Pro Val 
        435                 440                 445             
Lys Leu Ser Ala Glu Gly Pro Thr Thr Met Thr Leu Val Cys Gly Lys 
    450                 455                 460                 
Asp Gly Val Lys Val Pro Gln Asp Asn Asn Gln Tyr Cys Ser Gly Thr 
465                 470                 475                 480 
Thr Leu Thr Gly Cys Asn Glu Lys Ser Phe Lys Asp Ile Leu Pro Lys 
                485                 490                 495     
Leu Thr Glu Asn Pro Trp Gln Gly Asn Ala Ser Ser Asp Lys Gly Ala 
            500                 505                 510         
Thr Leu Thr Ile Lys Lys Glu Ala Phe Pro Ala Glu Ser Lys Ser Val 
        515                 520                 525             
Ile Ile Gly Cys Thr Gly Gly Ser Pro Glu Lys His His Cys Thr Val 
    530                 535                 540                 
Lys Leu Glu Phe Ala 
545                 

<210> 31
<211> 326
<212> PRT
<213> Artificial Sequence


<220> 
<223> DC2

<400> 31
Met Phe Pro Lys Ala Val Arg Arg Ala Val Thr Ala Gly Val Phe Ala 
1               5                   10                  15      
Ala Pro Thr Leu Met Ser Phe Leu Arg Cys Gly Val Met Ala Ser Asp 
            20                  25                  30          
Pro Thr Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Val Gln Leu 
        35                  40                  45              
Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    50                  55                  60                  
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn Trp 
65                  70                  75                  80  
Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile Arg 
                85                  90                  95      
Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys Gly 
            100                 105                 110         
Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu Gln 
        115                 120                 125             
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    130                 135                 140                 
Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly Gln 
145                 150                 155                 160 
Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            180                 185                 190         
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        195                 200                 205             
Ser Gln Asn Ile Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly 
    210                 215                 220                 
Asn Ala Pro Gln Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly 
225                 230                 235                 240 
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe 
                245                 250                 255     
Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            260                 265                 270         
His Tyr Gln Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        275                 280                 285             
Leu Lys Gly Gly Gly Ala Ser Ser Arg Glu Asp Leu Ala Ala Gly Thr 
    290                 295                 300                 
Ala Ser His Val Ser Ile Phe Ala Met Val Ile Gly Leu Ile Gly Ser 
305                 310                 315                 320 
Ile Ala Ala Cys Val Ala 
                325     

<210> 32
<211> 580
<212> PRT
<213> Artificial Sequence


<220> 
<223> DC2-SAG1

<400> 32
Met Phe Pro Lys Ala Val Arg Arg Ala Val Thr Ala Gly Val Phe Ala 
1               5                   10                  15      
Ala Pro Thr Leu Met Ser Phe Leu Arg Cys Gly Val Met Ala Ser Asp 
            20                  25                  30          
Pro Thr Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gln Val Gln Leu 
        35                  40                  45              
Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    50                  55                  60                  
Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Phe Tyr Met Asn Trp 
65                  70                  75                  80  
Ile Arg Gln Pro Pro Gly Gln Ala Pro Glu Trp Leu Gly Val Ile Arg 
                85                  90                  95      
Asn Lys Gly Asn Gly Tyr Thr Thr Glu Val Asn Thr Ser Val Lys Gly 
            100                 105                 110         
Arg Phe Thr Ile Ser Arg Asp Asn Thr Gln Asn Ile Leu Tyr Leu Gln 
        115                 120                 125             
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
    130                 135                 140                 
Gly Gly Pro Tyr Tyr Tyr Ser Gly Asp Asp Ala Pro Tyr Trp Gly Gln 
145                 150                 155                 160 
Gly Val Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                165                 170                 175     
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 
            180                 185                 190         
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        195                 200                 205             
Ser Gln Asn Ile Lys Gly Trp Leu Ala Trp Tyr Gln Gln Lys Ser Gly 
    210                 215                 220                 
Asn Ala Pro Gln Leu Leu Ile Tyr Lys Ala Ser Ser Leu Gln Ser Gly 
225                 230                 235                 240 
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ile Phe 
                245                 250                 255     
Thr Ile Ser Asn Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln 
            260                 265                 270         
His Tyr Gln Ser Phe Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        275                 280                 285             
Leu Lys Gly Gly Gly Ala Ser Ser Arg Pro Leu Val Ala Asn Gln Val 
    290                 295                 300                 
Val Thr Cys Pro Asp Lys Lys Ser Thr Ala Ala Val Ile Leu Thr Pro 
305                 310                 315                 320 
Thr Glu Asn His Phe Thr Leu Lys Cys Pro Lys Thr Ala Leu Thr Glu 
                325                 330                 335     
Pro Pro Thr Leu Ala Tyr Ser Pro Asn Arg Gln Ile Cys Pro Ala Gly 
            340                 345                 350         
Thr Thr Ser Ser Cys Thr Ser Lys Ala Val Thr Leu Ser Ser Leu Ile 
        355                 360                 365             
Pro Glu Ala Glu Asp Ser Trp Trp Thr Gly Asp Ser Ala Ser Leu Asp 
    370                 375                 380                 
Thr Ala Gly Ile Lys Leu Thr Val Pro Ile Glu Lys Phe Pro Val Thr 
385                 390                 395                 400 
Thr Gln Thr Phe Val Val Gly Cys Ile Lys Gly Asp Asp Ala Gln Ser 
                405                 410                 415     
Cys Met Val Thr Val Thr Val Gln Ala Arg Ala Ser Ser Val Val Asn 
            420                 425                 430         
Asn Val Ala Arg Cys Ser Tyr Gly Ala Asp Ser Thr Leu Gly Pro Val 
        435                 440                 445             
Lys Leu Ser Ala Glu Gly Pro Thr Thr Met Thr Leu Val Cys Gly Lys 
    450                 455                 460                 
Asp Gly Val Lys Val Pro Gln Asp Asn Asn Gln Tyr Cys Ser Gly Thr 
465                 470                 475                 480 
Thr Leu Thr Gly Cys Asn Glu Lys Ser Phe Lys Asp Ile Leu Pro Lys 
                485                 490                 495     
Leu Thr Glu Asn Pro Trp Gln Gly Asn Ala Ser Ser Asp Lys Gly Ala 
            500                 505                 510         
Thr Leu Thr Ile Lys Lys Glu Ala Phe Pro Ala Glu Ser Lys Ser Val 
        515                 520                 525             
Ile Ile Gly Cys Thr Gly Gly Ser Pro Glu Lys His His Cys Thr Val 
    530                 535                 540                 
Lys Leu Glu Phe Ala Ser Arg Glu Asp Leu Ala Ala Gly Thr Ala Ser 
545                 550                 555                 560 
His Val Ser Ile Phe Ala Met Val Ile Gly Leu Ile Gly Ser Ile Ala 
                565                 570                 575     
Ala Cys Val Ala 
            580 

<210> 33
<211> 765
<212> PRT
<213> Artificial Sequence


<220> 
<223> ScFv and HA

<400> 33
Thr Ala Cys Cys Cys Ala Thr Ala Cys Gly Ala Thr Gly Thr Thr Cys 
1               5                   10                  15      
Cys Ala Gly Ala Thr Thr Ala Cys Gly Cys Thr Cys Ala Gly Gly Thr 
            20                  25                  30          
Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly Ala Gly Ala Gly Thr 
        35                  40                  45              
Gly Gly Cys Gly Gly Ala Gly Gly Ala Cys Thr Gly Gly Thr Gly Cys 
    50                  55                  60                  
Ala Gly Cys Cys Ala Gly Gly Cys Gly Gly Ala Ala Gly Thr Cys Thr 
65                  70                  75                  80  
Gly Cys Gly Cys Cys Thr Gly Ala Gly Thr Thr Gly Cys Gly Cys Cys 
                85                  90                  95      
Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Thr Cys Ala Cys Cys Thr 
            100                 105                 110         
Thr Cys Ala Ala Cys Gly Ala Thr Thr Thr Cys Thr Ala Cys Ala Thr 
        115                 120                 125             
Gly Ala Ala Cys Thr Gly Gly Ala Thr Thr Cys Gly Cys Cys Ala Gly 
    130                 135                 140                 
Cys Cys Cys Cys Cys Ala Gly Gly Cys Cys Ala Gly Gly Cys Cys Cys 
145                 150                 155                 160 
Cys Ala Gly Ala Gly Thr Gly Gly Cys Thr Gly Gly Gly Ala Gly Thr 
                165                 170                 175     
Gly Ala Thr Thr Cys Gly Cys Ala Ala Cys Ala Ala Gly Gly Gly Cys 
            180                 185                 190         
Ala Ala Cys Gly Gly Cys Thr Ala Cys Ala Cys Cys Ala Cys Cys Gly 
        195                 200                 205             
Ala Ala Gly Thr Gly Ala Ala Cys Ala Cys Cys Ala Gly Cys Gly Thr 
    210                 215                 220                 
Gly Ala Ala Gly Gly Gly Ala Cys Gly Cys Thr Thr Cys Ala Cys Cys 
225                 230                 235                 240 
Ala Thr Cys Ala Gly Cys Cys Gly Cys Gly Ala Thr Ala Ala Cys Ala 
                245                 250                 255     
Cys Cys Cys Ala Gly Ala Ala Cys Ala Thr Cys Cys Thr Gly Thr Ala 
            260                 265                 270         
Cys Thr Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys 
        275                 280                 285             
Cys Thr Gly Cys Gly Cys Gly Cys Cys Gly Ala Gly Gly Ala Thr Ala 
    290                 295                 300                 
Cys Cys Gly Cys Cys Ala Thr Cys Thr Ala Cys Thr Ala Thr Thr Gly 
305                 310                 315                 320 
Cys Gly Cys Cys Cys Gly Cys Gly Gly Cys Gly Gly Cys Cys Cys Cys 
                325                 330                 335     
Thr Ala Cys Thr Ala Cys Thr Ala Cys Ala Gly Cys Gly Gly Ala Gly 
            340                 345                 350         
Ala Thr Gly Ala Thr Gly Cys Cys Cys Cys Cys Thr Ala Cys Thr Gly 
        355                 360                 365             
Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys Gly Thr Gly Ala Thr Gly 
    370                 375                 380                 
Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Cys Ala Gly Thr Gly 
385                 390                 395                 400 
Gly Cys Gly Gly Ala Gly Gly Cys Gly Gly Ala Thr Cys Cys Gly Gly 
                405                 410                 415     
Cys Gly Gly Ala Gly Gly Cys Gly Gly Ala Ala Gly Cys Gly Gly Ala 
            420                 425                 430         
Gly Gly Cys Gly Gly Ala Gly Gly Cys Ala Gly Thr Gly Ala Cys Ala 
        435                 440                 445             
Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys Ala Gly Ala Gly 
    450                 455                 460                 
Cys Cys Cys Cys Ala Gly Thr Thr Cys Cys Cys Thr Gly Ala Gly Cys 
465                 470                 475                 480 
Gly Cys Cys Ala Gly Thr Gly Thr Gly Gly Gly Ala Gly Ala Thr Cys 
                485                 490                 495     
Gly Cys Gly Thr Gly Ala Cys Cys Ala Thr Thr Ala Cys Cys Thr Gly 
            500                 505                 510         
Cys Cys Gly Cys Gly Cys Cys Thr Cys Gly Cys Ala Gly Ala Ala Cys 
        515                 520                 525             
Ala Thr Cys Ala Ala Gly Gly Gly Cys Thr Gly Gly Cys Thr Gly Gly 
    530                 535                 540                 
Cys Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
545                 550                 555                 560 
Gly Thr Cys Cys Gly Gly Ala Ala Ala Cys Gly Cys Cys Cys Cys Cys 
                565                 570                 575     
Cys Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Ala 
            580                 585                 590         
Ala Gly Gly Cys Cys Ala Gly Cys Ala Gly Thr Thr Thr Gly Cys Ala 
        595                 600                 605             
Gly Ala Gly Cys Gly Gly Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys 
    610                 615                 620                 
Cys Gly Cys Thr Thr Thr Ala Gly Cys Gly Gly Ala Ala Gly Thr Gly 
625                 630                 635                 640 
Gly Ala Ala Gly Cys Gly Gly Cys Ala Cys Cys Gly Ala Thr Thr Ala 
                645                 650                 655     
Cys Ala Thr Cys Thr Thr Cys Ala Cys Cys Ala Thr Thr Ala Gly Cys 
            660                 665                 670         
Ala Ala Cys Thr Thr Gly Cys Ala Gly Cys Cys Cys Gly Ala Gly Gly 
        675                 680                 685             
Ala Cys Ala Thr Thr Gly Cys Cys Ala Cys Cys Thr Ala Cys Thr Ala 
    690                 695                 700                 
Cys Thr Gly Cys Cys Ala Gly Cys Ala Cys Thr Ala Cys Cys Ala Gly 
705                 710                 715                 720 
Ala Gly Cys Thr Thr Cys Cys Cys Gly Thr Gly Gly Ala Cys Cys Thr 
                725                 730                 735     
Thr Cys Gly Gly Cys Gly Gly Ala Gly Gly Thr Ala Cys Cys Ala Ala 
            740                 745                 750         
Gly Cys Thr Gly Gly Ala Gly Cys Thr Gly Ala Ala Gly 
        755                 760                 765 

<210> 34
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 34
ggttttgacg tcaccatgtt tccgaaggca gtg                                  33


<210> 35
<211> 32
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer

<400> 35
ttgctcacca tcctaggtgc agccccggca aa                                   32


<210> 36
<211> 32
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 36
tttgccgggg ctgcacctag gatggtgagc aa                                   32


<210> 37
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 37
cggtgattaa ttaatcgagc gggtcctggt tcg                                  33


<210> 38
<211> 86
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 38
gcggccaagc ttataacttc gtataatgta tgctatacga agttatgata tgcatgtccg     60

cgttcgtgaa atctctgatc aagcgg                                          86


<210> 39
<211> 85
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 39
cgacgcacgc tgtcactcaa cttgctgcta gaactagtgg atccataact tcgtatagca     60

tacattatac gaagttatcc ctcgg                                           85


<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 40
gtatcgataa gcttataact c                                              21


<210> 41
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 41
cacaacggtg attaacctag gagccccgcc ctg                                  33


<210> 42
<211> 28
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 42
caaacaccta gggatcaagc cagagagc                                       28


<210> 43
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 43
gttccctagg ggaaacacat ctgcc                                          25


<210> 44
<211> 35
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 44
ggtgctcacc ggtttaaacg tcgaaaatgt ttccg                                35


<210> 45
<211> 28
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 45
ctcaccattc tagaggaaac acatctgc                                       28


<210> 46
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 46
ctcatctcta gagaggatct ggctgcggg                                      29


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 47
accatggaag cggccgctta cgcgaca                                        27


<210> 48
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 48
ggcaacacta gtgggatccg atgc                                           24


<210> 49
<211> 59
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 49
ctcgggacta gttacccata cgatgttcca gattacgctc aggtgcagct gcaggagag      59


<210> 50
<211> 37
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 50
attggccact ctagagctag cgcctccgcc cttcagc                              37


<210> 51
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 51
atggcatcgt ctagacctct tgttgccaat                                     30


<210> 52
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 52
cctaggtgct ctagaggcaa actccag                                        27


<210> 53
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> primer

<400> 53
ggttttgacg tcaccatgtt tccgaaggca gtg                                  33


<210> 54
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> primer

<400> 54
Thr Thr Gly Cys Thr Cys Ala Cys Cys Ala Thr Cys Cys Thr Ala Gly 
1               5                   10                  15      
Gly Thr Gly Cys Ala Gly Cys Cys Cys Cys Gly Gly Cys Ala Ala Ala 
            20                  25                  30          



<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> linker

<400> 55
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 56
<211> 741
<212> DNA
<213> Artificial Sequence


<220> 
<223> scFv

<400> 56
gaggtgcaac tcgtcgaaag cgggggcggt ttggtgcaac ctgggggaag cctgcggttg      60

tcttgcgccg caagcggctt tacgttttcc gattcgtgga ttcattgggt gagacaagcc     120

ccaggtaagg ggctcgaatg ggtggcgtgg atcagtccgt atggtggatc gacttattac     180

gcggactctg tgaaaggaag gtttacaatc tccgcggata cgtccaaaaa taccgcatat     240

ttgcagatga atagccttcg cgcagaggac acagcagttt attactgcgc ccggagacat     300

tggccaggcg gcttcgatta ctgggggcaa ggtacgctgg ttacagttag cagcggggga     360

ggaggatctg ggggaggtgg gtcgggaggg ggaggttccg acatccaaat gactcagtcg     420

ccatctagtc tttctgcctc tgtgggggat cgtgttacca tcacgtgccg tgccagccag     480

gacgttagca ctgctgtggc ctggtaccag caaaagccgg ggaaggcacc caaacttctg     540

atctatagtg cgtcgttcct ctatagtggc gttccgtcgc gcttctctgg tagtggctcc     600

ggcaccgact ttaccctgac aatcagtagc ctgcagcctg aggacttcgc tacctattat     660

tgccaacaat acctgtacca cccggcaacc ttcggtcaag gaaccaaagt ggagattaaa     720

ggaggggggg ccagttccag a                                               741


<210> 57
<211> 247
<212> PRT
<213> Artificial Sequence


<220> 
<223> scFv

<400> 57
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 
Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
145                 150                 155                 160 
Asp Val Ser Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
                165                 170                 175     
Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
            180                 185                 190         
Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
    210                 215                 220                 
Leu Tyr His Pro Ala Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 
Gly Gly Gly Ala Ser Ser Arg 
                245         

