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\plain\plain\f0\fs22\ql\plain\f1\fs22                SEQUENCE LISTING\par
\par
\pard\plain\f0\fs22\plain\f1\fs22 <110> Inoue Asuka, Robert Bruce Russell\par
\par
\ql\plain\f0\fs22\plain\f1\fs22 <120> Method and System for predicting coupling probabilities of G-protein coupled receptors\par
\par
<130> C4692WO\par
\par
<160> 114\par
\par
<170> BiSSAP 1.3.6\par
\par
<210> 1\par
<211> 502\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> DREADD M3D\par
\par
<400> 1\par
Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Thr Leu His Asn Asn \par
1               5                   10                  15      \par
Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile Ser Ser Ser Trp Ile His \par
            20                  25                  30          \par
Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly Thr Val Thr His Phe Gly \par
        35                  40                  45              \par
Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn Phe Ser Ser Pro Asp Gly \par
    50                  55                  60                  \par
Thr Thr Asp Asp Pro Leu Gly Gly His Thr Val Trp Gln Val Val Phe \par
65                  70                  75                  80  \par
Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu Val Thr Ile Ile Gly Asn \par
                85                  90                  95      \par
Ile Leu Val Ile Val Ser Phe Lys Val Asn Lys Gln Leu Lys Thr Val \par
            100                 105                 110         \par
Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly \par
        115                 120                 125             \par
Val Ile Ser Met Asn Leu Phe Thr Thr Tyr Ile Ile Met Asn Arg Trp \par
    130                 135                 140                 \par
Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp Leu Ala Ile Asp Cys Val \par
145                 150                 155                 160 \par
Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg \par
                165                 170                 175     \par
Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Thr \par
            180                 185                 190         \par
Lys Arg Ala Gly Val Met Ile Gly Leu Ala Trp Val Ile Ser Phe Val \par
        195                 200                 205             \par
Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Tyr Phe Val Gly Lys Arg \par
    210                 215                 220                 \par
Thr Val Pro Pro Gly Glu Cys Phe Ile Gln Phe Leu Ser Glu Pro Thr \par
225                 230                 235                 240 \par
Ile Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Met Pro Val Thr Ile \par
                245                 250                 255     \par
Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys Glu Thr Glu Lys Arg Thr \par
            260                 265                 270         \par
Lys Glu Leu Ala Gly Leu Gln Ala Ser Gly Thr Glu Ala Glu Thr Glu \par
        275                 280                 285             \par
Asn Phe Val His Pro Thr Gly Ser Ser Arg Ser Cys Ser Ser Tyr Glu \par
    290                 295                 300                 \par
Leu Gln Gln Gln Ser Met Lys Arg Ser Asn Arg Arg Lys Tyr Gly Arg \par
305                 310                 315                 320 \par
Cys His Phe Trp Phe Thr Thr Lys Ser Trp Lys Pro Ser Ser Glu Gln \par
                325                 330                 335     \par
Met Asp Gln Asp His Ser Ser Ser Asp Ser Trp Asn Asn Asn Asp Ala \par
            340                 345                 350         \par
Ala Ala Ser Leu Glu Asn Ser Ala Ser Ser Asp Glu Glu Asp Ile Gly \par
        355                 360                 365             \par
Ser Glu Thr Arg Ala Ile Tyr Ser Ile Val Leu Lys Leu Pro Gly His \par
    370                 375                 380                 \par
Ser Thr Ile Leu Asn Ser Thr Lys Leu Pro Ser Ser Asp Asn Leu Gln \par
385                 390                 395                 400 \par
Val Pro Glu Glu Glu Leu Gly Met Val Asp Leu Glu Arg Lys Ala Asp \par
                405                 410                 415     \par
Lys Leu Gln Ala Gln Lys Ser Val Asp Asp Gly Gly Ser Phe Pro Lys \par
            420                 425                 430         \par
Ser Phe Ser Lys Leu Pro Ile Gln Leu Glu Ser Ala Val Asp Thr Ala \par
        435                 440                 445             \par
Lys Thr Ser Asp Val Asn Ser Ser Val Gly Lys Ser Thr Ala Thr Leu \par
    450                 455                 460                 \par
Pro Leu Ser Phe Lys Glu Ala Thr Leu Ala Lys Arg Phe Ala Leu Lys \par
465                 470                 475                 480 \par
Thr Arg Ser Gln Ile Thr Lys Arg Lys Arg Met Ser Leu Val Lys Glu \par
                485                 490                 495     \par
Lys Lys Ala Ala Gln Thr \par
            500         \par
\par
<210> 2\par
<211> 388\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> M3D-GPR183/ICL3\par
\par
<400> 2\par
Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Thr Leu His Asn Asn \par
1               5                   10                  15      \par
Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile Ser Ser Ser Trp Ile His \par
            20                  25                  30          \par
Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly Thr Val Thr His Phe Gly \par
        35                  40                  45              \par
Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn Phe Ser Ser Pro Asp Gly \par
    50                  55                  60                  \par
Thr Thr Asp Asp Pro Leu Gly Gly His Thr Val Trp Gln Val Val Phe \par
65                  70                  75                  80  \par
Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu Val Thr Ile Ile Gly Asn \par
                85                  90                  95      \par
Ile Leu Val Ile Val Ser Phe Lys Val Asn Lys Gln Leu Lys Thr Val \par
            100                 105                 110         \par
Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly \par
        115                 120                 125             \par
Val Ile Ser Met Asn Leu Phe Thr Thr Tyr Ile Ile Met Asn Arg Trp \par
    130                 135                 140                 \par
Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp Leu Ala Ile Asp Cys Val \par
145                 150                 155                 160 \par
Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg \par
                165                 170                 175     \par
Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Thr \par
            180                 185                 190         \par
Lys Arg Ala Gly Val Met Ile Gly Leu Ala Trp Val Ile Ser Phe Val \par
        195                 200                 205             \par
Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Tyr Phe Val Gly Lys Arg \par
    210                 215                 220                 \par
Thr Val Pro Pro Gly Glu Cys Phe Ile Gln Phe Leu Ser Glu Pro Thr \par
225                 230                 235                 240 \par
Ile Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Met Pro Val Thr Ile \par
                245                 250                 255     \par
Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys Glu Thr Glu Arg Thr Ala \par
            260                 265                 270         \par
Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val Glu Lys Lys Ala Ala \par
        275                 280                 285             \par
Gln Thr Leu Ser Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro \par
    290                 295                 300                 \par
Tyr Asn Ile Met Val Leu Val Asn Thr Phe Cys Asp Ser Cys Ile Pro \par
305                 310                 315                 320 \par
Lys Thr Phe Trp Asn Leu Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr \par
                325                 330                 335     \par
Val Asn Pro Val Cys Tyr Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr \par
            340                 345                 350         \par
Phe Lys Met Leu Leu Leu Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys \par
        355                 360                 365             \par
Gln Gln Tyr Gln Gln Arg Gln Ser Val Ile Phe His Lys Arg Ala Pro \par
    370                 375                 380                 \par
Glu Gln Ala Leu \par
385             \par
\par
<210> 3\par
<211> 383\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> M3D-GPR132/ICL3\par
\par
<400> 3\par
Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Thr Leu His Asn Asn \par
1               5                   10                  15      \par
Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile Ser Ser Ser Trp Ile His \par
            20                  25                  30          \par
Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly Thr Val Thr His Phe Gly \par
        35                  40                  45              \par
Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn Phe Ser Ser Pro Asp Gly \par
    50                  55                  60                  \par
Thr Thr Asp Asp Pro Leu Gly Gly His Thr Val Trp Gln Val Val Phe \par
65                  70                  75                  80  \par
Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu Val Thr Ile Ile Gly Asn \par
                85                  90                  95      \par
Ile Leu Val Ile Val Ser Phe Lys Val Asn Lys Gln Leu Lys Thr Val \par
            100                 105                 110         \par
Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly \par
        115                 120                 125             \par
Val Ile Ser Met Asn Leu Phe Thr Thr Tyr Ile Ile Met Asn Arg Trp \par
    130                 135                 140                 \par
Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp Leu Ala Ile Asp Cys Val \par
145                 150                 155                 160 \par
Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg \par
                165                 170                 175     \par
Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Thr \par
            180                 185                 190         \par
Lys Arg Ala Gly Val Met Ile Gly Leu Ala Trp Val Ile Ser Phe Val \par
        195                 200                 205             \par
Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Tyr Phe Val Gly Lys Arg \par
    210                 215                 220                 \par
Thr Val Pro Pro Gly Glu Cys Phe Ile Gln Phe Leu Ser Glu Pro Thr \par
225                 230                 235                 240 \par
Ile Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Met Pro Val Thr Ile \par
                245                 250                 255     \par
Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys Glu Thr Glu Gln Ser Met \par
            260                 265                 270         \par
Gly Leu Ser Ala Ala Gln Glu Lys Lys Ala Ala Gln Thr Leu Ser Ala \par
        275                 280                 285             \par
Ile Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro Tyr Asn Ile Met Val \par
    290                 295                 300                 \par
Leu Val Asn Thr Phe Cys Asp Ser Cys Ile Pro Lys Thr Phe Trp Asn \par
305                 310                 315                 320 \par
Leu Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr Val Asn Pro Val Cys \par
                325                 330                 335     \par
Tyr Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr Phe Lys Met Leu Leu \par
            340                 345                 350         \par
Leu Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys Gln Gln Tyr Gln Gln \par
        355                 360                 365             \par
Arg Gln Ser Val Ile Phe His Lys Arg Ala Pro Glu Gln Ala Leu \par
    370                 375                 380             \par
\par
<210> 4\par
<211> 388\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> M3D-GPR183/ICL3 (1.57V)\par
\par
<400> 4\par
Met Asp Tyr Lys Asp Asp Asp Asp Lys Gly Ser Thr Leu His Asn Asn \par
1               5                   10                  15      \par
Ser Thr Thr Ser Pro Leu Phe Pro Asn Ile Ser Ser Ser Trp Ile His \par
            20                  25                  30          \par
Ser Pro Ser Asp Ala Gly Leu Pro Pro Gly Thr Val Thr His Phe Gly \par
        35                  40                  45              \par
Ser Tyr Asn Val Ser Arg Ala Ala Gly Asn Phe Ser Ser Pro Asp Gly \par
    50                  55                  60                  \par
Thr Thr Asp Asp Pro Leu Gly Gly His Thr Val Trp Gln Val Val Phe \par
65                  70                  75                  80  \par
Ile Ala Phe Leu Thr Gly Ile Leu Ala Leu Val Thr Ile Ile Gly Asn \par
                85                  90                  95      \par
Ile Leu Val Ile Val Ser Val Lys Val Asn Lys Gln Leu Lys Thr Val \par
            100                 105                 110         \par
Asn Asn Tyr Phe Leu Leu Ser Leu Ala Cys Ala Asp Leu Ile Ile Gly \par
        115                 120                 125             \par
Val Ile Ser Met Asn Leu Phe Thr Thr Tyr Ile Ile Met Asn Arg Trp \par
    130                 135                 140                 \par
Ala Leu Gly Asn Leu Ala Cys Asp Leu Trp Leu Ala Ile Asp Cys Val \par
145                 150                 155                 160 \par
Ala Ser Asn Ala Ser Val Met Asn Leu Leu Val Ile Ser Phe Asp Arg \par
                165                 170                 175     \par
Tyr Phe Ser Ile Thr Arg Pro Leu Thr Tyr Arg Ala Lys Arg Thr Thr \par
            180                 185                 190         \par
Lys Arg Ala Gly Val Met Ile Gly Leu Ala Trp Val Ile Ser Phe Val \par
        195                 200                 205             \par
Leu Trp Ala Pro Ala Ile Leu Phe Trp Gln Tyr Phe Val Gly Lys Arg \par
    210                 215                 220                 \par
Thr Val Pro Pro Gly Glu Cys Phe Ile Gln Phe Leu Ser Glu Pro Thr \par
225                 230                 235                 240 \par
Ile Thr Phe Gly Thr Ala Ile Ala Gly Phe Tyr Met Pro Val Thr Ile \par
                245                 250                 255     \par
Met Thr Ile Leu Tyr Trp Arg Ile Tyr Lys Glu Thr Glu Arg Thr Ala \par
            260                 265                 270         \par
Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val Glu Lys Lys Ala Ala \par
        275                 280                 285             \par
Gln Thr Leu Ser Ala Ile Leu Leu Ala Phe Ile Ile Thr Trp Thr Pro \par
    290                 295                 300                 \par
Tyr Asn Ile Met Val Leu Val Asn Thr Phe Cys Asp Ser Cys Ile Pro \par
305                 310                 315                 320 \par
Lys Thr Phe Trp Asn Leu Gly Tyr Trp Leu Cys Tyr Ile Asn Ser Thr \par
                325                 330                 335     \par
Val Asn Pro Val Cys Tyr Ala Leu Cys Asn Lys Thr Phe Arg Thr Thr \par
            340                 345                 350         \par
Phe Lys Met Leu Leu Leu Cys Gln Cys Asp Lys Lys Lys Arg Arg Lys \par
        355                 360                 365             \par
Gln Gln Tyr Gln Gln Arg Gln Ser Val Ile Phe His Lys Arg Ala Pro \par
    370                 375                 380                 \par
Glu Gln Ala Leu \par
385             \par
\par
<210> 5\par
<211> 582\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s-Lg (GNAS-LgBiT)\par
\par
<400> 5\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala \par
65                  70                  75                  80  \par
Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys \par
                85                  90                  95      \par
Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn \par
            100                 105                 110         \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
        115                 120                 125             \par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
    130                 135                 140                 \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
145                 150                 155                 160 \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
                165                 170                 175     \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
            180                 185                 190         \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
        195                 200                 205             \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
    210                 215                 220                 \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
225                 230                 235                 240 \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
                245                 250                 255     \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
            260                 265                 270         \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly \par
        275                 280                 285             \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Pro Pro \par
    290                 295                 300                 \par
Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu \par
305                 310                 315                 320 \par
Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu \par
                325                 330                 335     \par
His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu \par
            340                 345                 350         \par
Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp \par
        355                 360                 365             \par
Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp \par
    370                 375                 380                 \par
Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe \par
385                 390                 395                 400 \par
Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg \par
                405                 410                 415     \par
Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile \par
            420                 425                 430         \par
Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp \par
        435                 440                 445             \par
Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile \par
    450                 455                 460                 \par
Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn \par
465                 470                 475                 480 \par
Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile \par
                485                 490                 495     \par
Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala \par
            500                 505                 510         \par
Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe \par
        515                 520                 525             \par
Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg \par
    530                 535                 540                 \par
His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile \par
545                 550                 555                 560 \par
Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu \par
                565                 570                 575     \par
Arg Gln Tyr Glu Leu Leu \par
            580         \par
\par
<210> 6\par
<211> 542\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1i1-Lg (GNAI1-LgBiT)\par
\par
<400> 6\par
Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser \par
1               5                   10                  15      \par
Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg \par
            20                  25                  30          \par
Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr \par
        35                  40                  45              \par
Ile Val Lys Gln Met Lys Ile Ile His Glu Ala Gly Tyr Ser Glu Glu \par
    50                  55                  60                  \par
Glu Cys Lys Gln Tyr Lys Ala Val Val Tyr Ser Asn Thr Ile Gln Ser \par
65                  70                  75                  80  \par
Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Gly Gly Ser Gly Gly \par
                85                  90                  95      \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
            100                 105                 110         \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
        115                 120                 125             \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
    130                 135                 140                 \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
145                 150                 155                 160 \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
                165                 170                 175     \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
            180                 185                 190         \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
        195                 200                 205             \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
    210                 215                 220                 \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
225                 230                 235                 240 \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
                245                 250                 255     \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
            260                 265                 270         \par
Gly Gly Ser Ser Ser Gly Gly Lys Ile Asp Phe Gly Asp Ser Ala Arg \par
        275                 280                 285             \par
Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ala Ala Glu Glu \par
    290                 295                 300                 \par
Gly Phe Met Thr Ala Glu Leu Ala Gly Val Ile Lys Arg Leu Trp Lys \par
305                 310                 315                 320 \par
Asp Ser Gly Val Gln Ala Cys Phe Asn Arg Ser Arg Glu Tyr Gln Leu \par
                325                 330                 335     \par
Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Asp Arg Ile Ala Gln \par
            340                 345                 350         \par
Pro Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys \par
        355                 360                 365             \par
Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His Phe \par
    370                 375                 380                 \par
Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile \par
385                 390                 395                 400 \par
His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser \par
                405                 410                 415     \par
Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His \par
            420                 425                 430         \par
Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr \par
        435                 440                 445             \par
Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu \par
    450                 455                 460                 \par
Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Tyr Pro Glu Tyr Ala Gly \par
465                 470                 475                 480 \par
Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys Gln Phe Glu \par
                485                 490                 495     \par
Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr \par
            500                 505                 510         \par
Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr \par
        515                 520                 525             \par
Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe \par
    530                 535                 540         \par
\par
<210> 7\par
<211> 543\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1i2-Lg (GNAI2-LgBiT)\par
\par
<400> 7\par
Met Gly Cys Thr Val Ser Ala Glu Asp Lys Ala Ala Ala Glu Arg Ser \par
1               5                   10                  15      \par
Lys Met Ile Asp Lys Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Arg \par
            20                  25                  30          \par
Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr \par
        35                  40                  45              \par
Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Glu \par
    50                  55                  60                  \par
Glu Cys Arg Gln Tyr Arg Ala Val Val Tyr Ser Asn Thr Ile Gln Ser \par
65                  70                  75                  80  \par
Ile Met Ala Ile Val Lys Ala Met Gly Asn Leu Gly Gly Ser Gly Gly \par
                85                  90                  95      \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
            100                 105                 110         \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
        115                 120                 125             \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
    130                 135                 140                 \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
145                 150                 155                 160 \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
                165                 170                 175     \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
            180                 185                 190         \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
        195                 200                 205             \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
    210                 215                 220                 \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
225                 230                 235                 240 \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
                245                 250                 255     \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
            260                 265                 270         \par
Gly Gly Ser Ser Ser Gly Gly Gln Ile Asp Phe Ala Asp Pro Ser Arg \par
        275                 280                 285             \par
Ala Asp Asp Ala Arg Gln Leu Phe Ala Leu Ser Cys Thr Ala Glu Glu \par
    290                 295                 300                 \par
Gln Gly Val Leu Pro Asp Asp Leu Ser Gly Val Ile Arg Arg Leu Trp \par
305                 310                 315                 320 \par
Ala Asp His Gly Val Gln Ala Cys Phe Gly Arg Ser Arg Glu Tyr Gln \par
                325                 330                 335     \par
Leu Asn Asp Ser Ala Ala Tyr Tyr Leu Asn Asp Leu Glu Arg Ile Ala \par
            340                 345                 350         \par
Gln Ser Asp Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val \par
        355                 360                 365             \par
Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu His \par
    370                 375                 380                 \par
Phe Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp \par
385                 390                 395                 400 \par
Ile His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu \par
                405                 410                 415     \par
Ser Ala Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met \par
            420                 425                 430         \par
His Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe \par
        435                 440                 445             \par
Thr Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu \par
    450                 455                 460                 \par
Glu Lys Ile Thr His Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr \par
465                 470                 475                 480 \par
Gly Ala Asn Lys Tyr Asp Glu Ala Ala Ser Tyr Ile Gln Ser Lys Phe \par
                485                 490                 495     \par
Glu Asp Leu Asn Lys Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe \par
            500                 505                 510         \par
Thr Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val \par
        515                 520                 525             \par
Thr Asp Val Ile Ile Lys Asn Asn Leu Lys Asp Cys Gly Leu Phe \par
    530                 535                 540             \par
\par
<210> 8\par
<211> 542\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1i3-Lg (GNAI3-LgBiT)\par
\par
<400> 8\par
Met Gly Cys Thr Leu Ser Ala Glu Asp Lys Ala Ala Val Glu Arg Ser \par
1               5                   10                  15      \par
Lys Met Ile Asp Arg Asn Leu Arg Glu Asp Gly Glu Lys Ala Ala Lys \par
            20                  25                  30          \par
Glu Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr \par
        35                  40                  45              \par
Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Tyr Ser Glu Asp \par
    50                  55                  60                  \par
Glu Cys Lys Gln Tyr Lys Val Val Val Tyr Ser Asn Thr Ile Gln Ser \par
65                  70                  75                  80  \par
Ile Ile Ala Ile Ile Arg Ala Met Gly Arg Leu Gly Gly Ser Gly Gly \par
                85                  90                  95      \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
            100                 105                 110         \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
        115                 120                 125             \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
    130                 135                 140                 \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
145                 150                 155                 160 \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
                165                 170                 175     \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
            180                 185                 190         \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
        195                 200                 205             \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
    210                 215                 220                 \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
225                 230                 235                 240 \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
                245                 250                 255     \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
            260                 265                 270         \par
Gly Gly Ser Ser Ser Gly Gly Lys Ile Asp Phe Gly Glu Ala Ala Arg \par
        275                 280                 285             \par
Ala Asp Asp Ala Arg Gln Leu Phe Val Leu Ala Gly Ser Ala Glu Glu \par
    290                 295                 300                 \par
Gly Val Met Thr Pro Glu Leu Ala Gly Val Ile Lys Arg Leu Trp Arg \par
305                 310                 315                 320 \par
Asp Gly Gly Val Gln Ala Cys Phe Ser Arg Ser Arg Glu Tyr Gln Leu \par
                325                 330                 335     \par
Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Asp Leu Asp Arg Ile Ser Gln \par
            340                 345                 350         \par
Ser Asn Tyr Ile Pro Thr Gln Gln Asp Val Leu Arg Thr Arg Val Lys \par
        355                 360                 365             \par
Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asp Leu Tyr Phe \par
    370                 375                 380                 \par
Lys Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile \par
385                 390                 395                 400 \par
His Cys Phe Glu Gly Val Thr Ala Ile Ile Phe Cys Val Ala Leu Ser \par
                405                 410                 415     \par
Asp Tyr Asp Leu Val Leu Ala Glu Asp Glu Glu Met Asn Arg Met His \par
            420                 425                 430         \par
Glu Ser Met Lys Leu Phe Asp Ser Ile Cys Asn Asn Lys Trp Phe Thr \par
        435                 440                 445             \par
Glu Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Glu Glu \par
    450                 455                 460                 \par
Lys Ile Lys Arg Ser Pro Leu Thr Ile Cys Tyr Pro Glu Tyr Thr Gly \par
465                 470                 475                 480 \par
Ser Asn Thr Tyr Glu Glu Ala Ala Ala Tyr Ile Gln Cys Gln Phe Glu \par
                485                 490                 495     \par
Asp Leu Asn Arg Arg Lys Asp Thr Lys Glu Ile Tyr Thr His Phe Thr \par
            500                 505                 510         \par
Cys Ala Thr Asp Thr Lys Asn Val Gln Phe Val Phe Asp Ala Val Thr \par
        515                 520                 525             \par
Asp Val Ile Ile Lys Asn Asn Leu Lys Glu Cys Gly Leu Tyr \par
    530                 535                 540         \par
\par
<210> 9\par
<211> 542\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1o-Lg (GNAO1-LgBiT)\par
\par
<400> 9\par
Met Gly Cys Thr Leu Ser Ala Glu Glu Arg Ala Ala Leu Glu Arg Ser \par
1               5                   10                  15      \par
Lys Ala Ile Glu Lys Asn Leu Lys Glu Asp Gly Ile Ser Ala Ala Lys \par
            20                  25                  30          \par
Asp Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr \par
        35                  40                  45              \par
Ile Val Lys Gln Met Lys Ile Ile His Glu Asp Gly Phe Ser Gly Glu \par
    50                  55                  60                  \par
Asp Val Lys Gln Tyr Lys Pro Val Val Tyr Ser Asn Thr Ile Gln Ser \par
65                  70                  75                  80  \par
Leu Ala Ala Ile Val Arg Ala Met Asp Thr Leu Gly Gly Ser Gly Gly \par
                85                  90                  95      \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
            100                 105                 110         \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
        115                 120                 125             \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
    130                 135                 140                 \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
145                 150                 155                 160 \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
                165                 170                 175     \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
            180                 185                 190         \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
        195                 200                 205             \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
    210                 215                 220                 \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
225                 230                 235                 240 \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
                245                 250                 255     \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
            260                 265                 270         \par
Gly Gly Ser Ser Ser Gly Gly Gly Ile Glu Tyr Gly Asp Lys Glu Arg \par
        275                 280                 285             \par
Lys Ala Asp Ala Lys Met Val Cys Asp Val Val Ser Arg Met Glu Asp \par
    290                 295                 300                 \par
Thr Glu Pro Phe Ser Ala Glu Leu Leu Ser Ala Met Met Arg Leu Trp \par
305                 310                 315                 320 \par
Gly Asp Ser Gly Ile Gln Glu Cys Phe Asn Arg Ser Arg Glu Tyr Gln \par
                325                 330                 335     \par
Leu Asn Asp Ser Ala Lys Tyr Tyr Leu Asp Ser Leu Asp Arg Ile Gly \par
            340                 345                 350         \par
Ala Ala Asp Tyr Gln Pro Thr Glu Gln Asp Ile Leu Arg Thr Arg Val \par
        355                 360                 365             \par
Lys Thr Thr Gly Ile Val Glu Thr His Phe Thr Phe Lys Asn Leu His \par
    370                 375                 380                 \par
Phe Arg Leu Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp \par
385                 390                 395                 400 \par
Ile His Cys Phe Glu Asp Val Thr Ala Ile Ile Phe Cys Val Ala Leu \par
                405                 410                 415     \par
Ser Gly Tyr Asp Gln Val Leu His Glu Asp Glu Thr Thr Asn Arg Met \par
            420                 425                 430         \par
His Glu Ser Leu Met Leu Phe Asp Ser Ile Cys Asn Asn Lys Phe Phe \par
        435                 440                 445             \par
Ile Asp Thr Ser Ile Ile Leu Phe Leu Asn Lys Lys Asp Leu Phe Gly \par
    450                 455                 460                 \par
Glu Lys Ile Lys Lys Ser Pro Leu Thr Ile Cys Phe Pro Glu Tyr Thr \par
465                 470                 475                 480 \par
Gly Pro Asn Thr Tyr Glu Asp Ala Ala Ala Tyr Ile Gln Ala Gln Phe \par
                485                 490                 495     \par
Glu Ser Lys Asn Arg Ser Pro Asn Lys Glu Ile Tyr Cys His Met Thr \par
            500                 505                 510         \par
Cys Ala Thr Asp Thr Asn Asn Ile Gln Val Val Phe Asp Ala Val Thr \par
        515                 520                 525             \par
Asp Ile Ile Ile Ala Asn Asn Leu Arg Gly Cys Gly Leu Tyr \par
    530                 535                 540         \par
\par
<210> 10\par
<211> 547\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q-Lg (GNAQ-LgBiT)\par
\par
<400> 10\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
            100                 105                 110         \par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
        115                 120                 125             \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
    130                 135                 140                 \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
145                 150                 155                 160 \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
                165                 170                 175     \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
            180                 185                 190         \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
        195                 200                 205             \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
    210                 215                 220                 \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
225                 230                 235                 240 \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
                245                 250                 255     \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly \par
            260                 265                 270         \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Lys Ile Pro \par
        275                 280                 285             \par
Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val \par
    290                 295                 300                 \par
Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp Ala Ile \par
305                 310                 315                 320 \par
Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg \par
                325                 330                 335     \par
Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu \par
            340                 345                 350         \par
Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu \par
        355                 360                 365             \par
Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu \par
    370                 375                 380                 \par
Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu \par
385                 390                 395                 400 \par
Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe \par
                405                 410                 415     \par
Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn \par
            420                 425                 430         \par
Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr \par
        435                 440                 445             \par
Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys \par
    450                 455                 460                 \par
Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe \par
465                 470                 475                 480 \par
Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe \par
                485                 490                 495     \par
Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile \par
            500                 505                 510         \par
Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val \par
        515                 520                 525             \par
Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr \par
    530                 535                 540                 \par
Asn Leu Val \par
545         \par
\par
<210> 11\par
<211> 547\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b111-Lg (GNA11-LgBiT)\par
\par
<400> 11\par
Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys \par
1               5                   10                  15      \par
Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr \par
                85                  90                  95      \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
            100                 105                 110         \par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
        115                 120                 125             \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
    130                 135                 140                 \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
145                 150                 155                 160 \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
                165                 170                 175     \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
            180                 185                 190         \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
        195                 200                 205             \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
    210                 215                 220                 \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
225                 230                 235                 240 \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
                245                 250                 255     \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly \par
            260                 265                 270         \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Lys Ile Leu \par
        275                 280                 285             \par
Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu Ile Arg Glu Val \par
    290                 295                 300                 \par
Asp Val Glu Lys Val Thr Thr Phe Glu His Gln Tyr Val Ser Ala Ile \par
305                 310                 315                 320 \par
Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg \par
                325                 330                 335     \par
Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Val \par
            340                 345                 350         \par
Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln Gln Asp Val Leu \par
        355                 360                 365             \par
Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu \par
    370                 375                 380                 \par
Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu \par
385                 390                 395                 400 \par
Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe \par
                405                 410                 415     \par
Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn \par
            420                 425                 430         \par
Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr \par
        435                 440                 445             \par
Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys \par
    450                 455                 460                 \par
Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu Val Asp Tyr Phe \par
465                 470                 475                 480 \par
Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe \par
                485                 490                 495     \par
Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile \par
            500                 505                 510         \par
Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val \par
        515                 520                 525             \par
Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr \par
    530                 535                 540                 \par
Asn Leu Val \par
545         \par
\par
<210> 12\par
<211> 543\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b114-Lg (GNA14-LgBiT)\par
\par
<400> 12\par
Met Ala Gly Cys Cys Cys Leu Ser Ala Glu Glu Lys Glu Ser Gln Arg \par
1               5                   10                  15      \par
Ile Ser Ala Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Lys Asp Ala \par
            20                  25                  30          \par
Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys \par
        35                  40                  45              \par
Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser \par
    50                  55                  60                  \par
Asp Glu Asp Arg Lys Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe \par
65                  70                  75                  80  \par
Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Gly Gly Ser \par
                85                  90                  95      \par
Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu \par
            100                 105                 110         \par
Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp \par
        115                 120                 125             \par
Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala \par
    130                 135                 140                 \par
Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala \par
145                 150                 155                 160 \par
Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala \par
                165                 170                 175     \par
Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val \par
            180                 185                 190         \par
Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile \par
        195                 200                 205             \par
Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu \par
    210                 215                 220                 \par
Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu \par
225                 230                 235                 240 \par
Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly \par
                245                 250                 255     \par
Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly \par
            260                 265                 270         \par
Gly Ser Gly Gly Ser Ser Ser Gly Gly Arg Ile Gln Tyr Val Cys Glu \par
        275                 280                 285             \par
Gln Asn Lys Glu Asn Ala Gln Ile Ile Arg Glu Val Glu Val Asp Lys \par
    290                 295                 300                 \par
Val Ser Met Leu Ser Arg Glu Gln Val Glu Ala Ile Lys Gln Leu Trp \par
305                 310                 315                 320 \par
Gln Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu Tyr Gln \par
                325                 330                 335     \par
Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Ile Asp Arg Ile Ala \par
            340                 345                 350         \par
Thr Pro Ser Phe Val Pro Thr Gln Gln Asp Val Leu Arg Val Arg Val \par
        355                 360                 365             \par
Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Glu Asn Ile Ile \par
    370                 375                 380                 \par
Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg Arg Lys Trp \par
385                 390                 395                 400 \par
Ile His Cys Phe Glu Ser Val Thr Ser Ile Ile Phe Leu Val Ala Leu \par
                405                 410                 415     \par
Ser Glu Tyr Asp Gln Val Leu Ala Glu Cys Asp Asn Glu Asn Arg Met \par
            420                 425                 430         \par
Glu Glu Ser Lys Ala Leu Phe Lys Thr Ile Ile Thr Tyr Pro Trp Phe \par
        435                 440                 445             \par
Leu Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys Asp Leu Leu Glu \par
    450                 455                 460                 \par
Glu Lys Ile Met Tyr Ser His Leu Ile Ser Tyr Phe Pro Glu Tyr Thr \par
465                 470                 475                 480 \par
Gly Pro Lys Gln Asp Val Arg Ala Ala Arg Asp Phe Ile Leu Lys Leu \par
                485                 490                 495     \par
Tyr Gln Asp Gln Asn Pro Asp Lys Glu Lys Val Ile Tyr Ser His Phe \par
            500                 505                 510         \par
Thr Cys Ala Thr Asp Thr Asp Asn Ile Arg Phe Val Phe Ala Ala Val \par
        515                 520                 525             \par
Lys Asp Thr Ile Leu Gln Leu Asn Leu Arg Glu Phe Asn Leu Val \par
    530                 535                 540             \par
\par
<210> 13\par
<211> 562\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b116-Lg (GNA15-LgBiT)\par
\par
<400> 13\par
Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu \par
1               5                   10                  15      \par
Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu \par
            20                  25                  30          \par
Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu \par
        35                  40                  45              \par
Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile \par
    50                  55                  60                  \par
Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro \par
65                  70                  75                  80  \par
Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala \par
                85                  90                  95      \par
Met Glu Arg Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser \par
            100                 105                 110         \par
Ser Gly Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln \par
        115                 120                 125             \par
Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser \par
    130                 135                 140                 \par
Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile \par
145                 150                 155                 160 \par
Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile \par
                165                 170                 175     \par
Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val \par
            180                 185                 190         \par
Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu \par
        195                 200                 205             \par
Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn \par
    210                 215                 220                 \par
Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys \par
225                 230                 235                 240 \par
Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu \par
                245                 250                 255     \par
Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn \par
            260                 265                 270         \par
Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
        275                 280                 285             \par
Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His Ala Ser Leu Val \par
    290                 295                 300                 \par
Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Phe Glu Lys Arg Tyr Ala \par
305                 310                 315                 320 \par
Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile Arg Ala Tyr Tyr \par
                325                 330                 335     \par
Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala Val Tyr Tyr Leu \par
            340                 345                 350         \par
Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val Pro Thr Ala Gln \par
        355                 360                 365             \par
Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile Asn Glu Tyr Cys \par
    370                 375                 380                 \par
Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp Val Gly Gly Gln \par
385                 390                 395                 400 \par
Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu Asn Val Ile Ala \par
                405                 410                 415     \par
Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln Cys Leu Glu Glu \par
            420                 425                 430         \par
Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala Leu Phe Gly Thr \par
        435                 440                 445             \par
Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val Ile Leu Phe Leu \par
    450                 455                 460                 \par
Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr Ser His Leu Ala \par
465                 470                 475                 480 \par
Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp Ala Glu Ala Ala \par
                485                 490                 495     \par
Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr Thr Gly Cys Val \par
            500                 505                 510         \par
Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser Arg Arg Leu Phe \par
        515                 520                 525             \par
Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile Arg Lys Val Phe \par
    530                 535                 540                 \par
Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu Asp Glu Ile Asn \par
545                 550                 555                 560 \par
Leu Leu \par
        \par
\par
<210> 14\par
<211> 569\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b112-Lg (GNA12-LgBiT)\par
\par
<400> 14\par
Met Ser Gly Val Val Arg Thr Leu Ser Arg Cys Leu Leu Pro Ala Glu \par
1               5                   10                  15      \par
Ala Gly Gly Ala Arg Glu Arg Arg Ala Gly Ser Gly Ala Arg Asp Ala \par
            20                  25                  30          \par
Glu Arg Glu Ala Arg Arg Arg Ser Arg Asp Ile Asp Ala Leu Leu Ala \par
        35                  40                  45              \par
Arg Glu Arg Arg Ala Val Arg Arg Leu Val Lys Ile Leu Leu Leu Gly \par
    50                  55                  60                  \par
Ala Gly Glu Ser Gly Lys Ser Thr Phe Leu Lys Gln Met Arg Ile Ile \par
65                  70                  75                  80  \par
His Gly Arg Glu Phe Asp Gln Lys Ala Leu Leu Glu Phe Arg Asp Thr \par
                85                  90                  95      \par
Ile Phe Asp Asn Ile Leu Lys Gly Ser Arg Val Leu Val Asp Ala Arg \par
            100                 105                 110         \par
Asp Lys Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser \par
        115                 120                 125             \par
Gly Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr \par
    130                 135                 140                 \par
Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser \par
145                 150                 155                 160 \par
Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val \par
                165                 170                 175     \par
Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro \par
            180                 185                 190         \par
Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe \par
        195                 200                 205             \par
Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro \par
    210                 215                 220                 \par
Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr \par
225                 230                 235                 240 \par
Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile \par
                245                 250                 255     \par
Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg \par
            260                 265                 270         \par
Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser \par
        275                 280                 285             \par
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Gly \par
    290                 295                 300                 \par
Ile Pro Trp Gln Tyr Ser Glu Asn Glu Lys His Gly Met Phe Leu Met \par
305                 310                 315                 320 \par
Ala Phe Glu Asn Lys Ala Gly Leu Pro Val Glu Pro Ala Thr Phe Gln \par
                325                 330                 335     \par
Leu Tyr Val Pro Ala Leu Ser Ala Leu Trp Arg Asp Ser Gly Ile Arg \par
            340                 345                 350         \par
Glu Ala Phe Ser Arg Arg Ser Glu Phe Gln Leu Gly Glu Ser Val Lys \par
        355                 360                 365             \par
Tyr Phe Leu Asp Asn Leu Asp Arg Ile Gly Gln Leu Asn Tyr Phe Pro \par
    370                 375                 380                 \par
Ser Lys Gln Asp Ile Leu Leu Ala Arg Lys Ala Thr Lys Gly Ile Val \par
385                 390                 395                 400 \par
Glu His Asp Phe Val Ile Lys Lys Ile Pro Phe Lys Met Val Asp Val \par
                405                 410                 415     \par
Gly Gly Gln Arg Ser Gln Arg Gln Lys Trp Phe Gln Cys Phe Asp Gly \par
            420                 425                 430         \par
Ile Thr Ser Ile Leu Phe Met Val Ser Ser Ser Glu Tyr Asp Gln Val \par
        435                 440                 445             \par
Leu Met Glu Asp Arg Arg Thr Asn Arg Leu Val Glu Ser Met Asn Ile \par
    450                 455                 460                 \par
Phe Glu Thr Ile Val Asn Asn Lys Leu Phe Phe Asn Val Ser Ile Ile \par
465                 470                 475                 480 \par
Leu Phe Leu Asn Lys Met Asp Leu Leu Val Glu Lys Val Lys Thr Val \par
                485                 490                 495     \par
Ser Ile Lys Lys His Phe Pro Asp Phe Arg Gly Asp Pro His Arg Leu \par
            500                 505                 510         \par
Glu Asp Val Gln Arg Tyr Leu Val Gln Cys Phe Asp Arg Lys Arg Arg \par
        515                 520                 525             \par
Asn Arg Ser Lys Pro Leu Phe His His Phe Thr Thr Ala Ile Asp Thr \par
    530                 535                 540                 \par
Glu Asn Val Arg Phe Val Phe His Ala Val Lys Asp Thr Ile Leu Gln \par
545                 550                 555                 560 \par
Glu Asn Leu Lys Asp Ile Met Leu Gln \par
                565                 \par
\par
<210> 15\par
<211> 565\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b113-Lg (GNA13-LgBiT)\par
\par
<400> 15\par
Met Ala Asp Phe Leu Pro Ser Arg Ser Val Leu Ser Val Cys Phe Pro \par
1               5                   10                  15      \par
Gly Cys Leu Leu Thr Ser Gly Glu Ala Glu Gln Gln Arg Lys Ser Lys \par
            20                  25                  30          \par
Glu Ile Asp Lys Cys Leu Ser Arg Glu Lys Thr Tyr Val Lys Arg Leu \par
        35                  40                  45              \par
Val Lys Ile Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Phe \par
    50                  55                  60                  \par
Leu Lys Gln Met Arg Ile Ile His Gly Gln Asp Phe Asp Gln Arg Ala \par
65                  70                  75                  80  \par
Arg Glu Glu Phe Arg Pro Thr Ile Tyr Ser Asn Val Ile Lys Gly Met \par
                85                  90                  95      \par
Arg Val Leu Val Asp Ala Arg Glu Lys Leu Gly Gly Ser Gly Gly Gly \par
            100                 105                 110         \par
Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp Phe \par
        115                 120                 125             \par
Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu \par
    130                 135                 140                 \par
Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val \par
145                 150                 155                 160 \par
Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile \par
                165                 170                 175     \par
Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met \par
            180                 185                 190         \par
Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His \par
        195                 200                 205             \par
His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val \par
    210                 215                 220                 \par
Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala \par
225                 230                 235                 240 \par
Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly \par
                245                 250                 255     \par
Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu \par
            260                 265                 270         \par
Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly \par
        275                 280                 285             \par
Gly Ser Ser Ser Gly Gly His Ile Pro Trp Gly Asp Asn Ser Asn Gln \par
    290                 295                 300                 \par
Gln His Gly Asp Lys Met Met Ser Phe Asp Thr Arg Ala Pro Met Ala \par
305                 310                 315                 320 \par
Ala Gln Gly Met Val Glu Thr Arg Val Phe Leu Gln Tyr Leu Pro Ala \par
                325                 330                 335     \par
Ile Arg Ala Leu Trp Ala Asp Ser Gly Ile Gln Asn Ala Tyr Asp Arg \par
            340                 345                 350         \par
Arg Arg Glu Phe Gln Leu Gly Glu Ser Val Lys Tyr Phe Leu Asp Asn \par
        355                 360                 365             \par
Leu Asp Lys Leu Gly Glu Pro Asp Tyr Ile Pro Ser Gln Gln Asp Ile \par
    370                 375                 380                 \par
Leu Leu Ala Arg Arg Pro Thr Lys Gly Ile His Glu Tyr Asp Phe Glu \par
385                 390                 395                 400 \par
Ile Lys Asn Val Pro Phe Lys Met Val Asp Val Gly Gly Gln Arg Ser \par
                405                 410                 415     \par
Glu Arg Lys Arg Trp Phe Glu Cys Phe Asp Ser Val Thr Ser Ile Leu \par
            420                 425                 430         \par
Phe Leu Val Ser Ser Ser Glu Phe Asp Gln Val Leu Met Glu Asp Arg \par
        435                 440                 445             \par
Leu Thr Asn Arg Leu Thr Glu Ser Leu Asn Ile Phe Glu Thr Ile Val \par
    450                 455                 460                 \par
Asn Asn Arg Val Phe Ser Asn Val Ser Ile Ile Leu Phe Leu Asn Lys \par
465                 470                 475                 480 \par
Thr Asp Leu Leu Glu Glu Lys Val Gln Ile Val Ser Ile Lys Asp Tyr \par
                485                 490                 495     \par
Phe Leu Glu Phe Glu Gly Asp Pro His Cys Leu Arg Asp Val Gln Lys \par
            500                 505                 510         \par
Phe Leu Val Glu Cys Phe Arg Asn Lys Arg Arg Asp Gln Gln Gln Lys \par
        515                 520                 525             \par
Pro Leu Tyr His His Phe Thr Thr Ala Ile Asn Thr Glu Asn Ile Arg \par
    530                 535                 540                 \par
Leu Val Phe Arg Asp Val Lys Asp Thr Ile Leu His Asp Asn Leu Lys \par
545                 550                 555                 560 \par
Gln Leu Met Leu Gln \par
                565 \par
\par
<210> 16\par
<211> 366\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b21 (SmBiT-GNB1)\par
\par
<400> 16\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Glu Leu Asp Gln \par
            20                  25                  30          \par
Leu Arg Gln Glu Ala Glu Gln Leu Lys Asn Gln Ile Arg Asp Ala Arg \par
        35                  40                  45              \par
Lys Ala Cys Ala Asp Ala Thr Leu Ser Gln Ile Thr Asn Asn Ile Asp \par
    50                  55                  60                  \par
Pro Val Gly Arg Ile Gln Met Arg Thr Arg Arg Thr Leu Arg Gly His \par
65                  70                  75                  80  \par
Leu Ala Lys Ile Tyr Ala Met His Trp Gly Thr Asp Ser Arg Leu Leu \par
                85                  90                  95      \par
Val Ser Ala Ser Gln Asp Gly Lys Leu Ile Ile Trp Asp Ser Tyr Thr \par
            100                 105                 110         \par
Thr Asn Lys Val His Ala Ile Pro Leu Arg Ser Ser Trp Val Met Thr \par
        115                 120                 125             \par
Cys Ala Tyr Ala Pro Ser Gly Asn Tyr Val Ala Cys Gly Gly Leu Asp \par
    130                 135                 140                 \par
Asn Ile Cys Ser Ile Tyr Asn Leu Lys Thr Arg Glu Gly Asn Val Arg \par
145                 150                 155                 160 \par
Val Ser Arg Glu Leu Ala Gly His Thr Gly Tyr Leu Ser Cys Cys Arg \par
                165                 170                 175     \par
Phe Leu Asp Asp Asn Gln Ile Val Thr Ser Ser Gly Asp Thr Thr Cys \par
            180                 185                 190         \par
Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln Thr Thr Thr Phe Thr Gly \par
        195                 200                 205             \par
His Thr Gly Asp Val Met Ser Leu Ser Leu Ala Pro Asp Thr Arg Leu \par
    210                 215                 220                 \par
Phe Val Ser Gly Ala Cys Asp Ala Ser Ala Lys Leu Trp Asp Val Arg \par
225                 230                 235                 240 \par
Glu Gly Met Cys Arg Gln Thr Phe Thr Gly His Glu Ser Asp Ile Asn \par
                245                 250                 255     \par
Ala Ile Cys Phe Phe Pro Asn Gly Asn Ala Phe Ala Thr Gly Ser Asp \par
            260                 265                 270         \par
Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg Ala Asp Gln Glu Leu Met \par
        275                 280                 285             \par
Thr Tyr Ser His Asp Asn Ile Ile Cys Gly Ile Thr Ser Val Ser Phe \par
    290                 295                 300                 \par
Ser Lys Ser Gly Arg Leu Leu Leu Ala Gly Tyr Asp Asp Phe Asn Cys \par
305                 310                 315                 320 \par
Asn Val Trp Asp Ala Leu Lys Ala Asp Arg Ala Gly Val Leu Ala Gly \par
                325                 330                 335     \par
His Asp Asn Arg Val Ser Cys Leu Gly Val Thr Asp Asp Gly Met Ala \par
            340                 345                 350         \par
Val Ala Thr Gly Ser Trp Asp Ser Phe Leu Lys Ile Trp Asn \par
        355                 360                 365     \par
\par
<210> 17\par
<211> 366\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b22 (SmBiT-GNB2)\par
\par
<400> 17\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Glu Leu Glu Gln \par
            20                  25                  30          \par
Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn Gln Ile Arg Asp Ala Arg \par
        35                  40                  45              \par
Lys Ala Cys Gly Asp Ser Thr Leu Thr Gln Ile Thr Ala Gly Leu Asp \par
    50                  55                  60                  \par
Pro Val Gly Arg Ile Gln Met Arg Thr Arg Arg Thr Leu Arg Gly His \par
65                  70                  75                  80  \par
Leu Ala Lys Ile Tyr Ala Met His Trp Gly Thr Asp Ser Arg Leu Leu \par
                85                  90                  95      \par
Val Ser Ala Ser Gln Asp Gly Lys Leu Ile Ile Trp Asp Ser Tyr Thr \par
            100                 105                 110         \par
Thr Asn Lys Val His Ala Ile Pro Leu Arg Ser Ser Trp Val Met Thr \par
        115                 120                 125             \par
Cys Ala Tyr Ala Pro Ser Gly Asn Phe Val Ala Cys Gly Gly Leu Asp \par
    130                 135                 140                 \par
Asn Ile Cys Ser Ile Tyr Ser Leu Lys Thr Arg Glu Gly Asn Val Arg \par
145                 150                 155                 160 \par
Val Ser Arg Glu Leu Pro Gly His Thr Gly Tyr Leu Ser Cys Cys Arg \par
                165                 170                 175     \par
Phe Leu Asp Asp Asn Gln Ile Ile Thr Ser Ser Gly Asp Thr Thr Cys \par
            180                 185                 190         \par
Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln Thr Val Gly Phe Ala Gly \par
        195                 200                 205             \par
His Ser Gly Asp Val Met Ser Leu Ser Leu Ala Pro Asp Gly Arg Thr \par
    210                 215                 220                 \par
Phe Val Ser Gly Ala Cys Asp Ala Ser Ile Lys Leu Trp Asp Val Arg \par
225                 230                 235                 240 \par
Asp Ser Met Cys Arg Gln Thr Phe Ile Gly His Glu Ser Asp Ile Asn \par
                245                 250                 255     \par
Ala Val Ala Phe Phe Pro Asn Gly Tyr Ala Phe Thr Thr Gly Ser Asp \par
            260                 265                 270         \par
Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg Ala Asp Gln Glu Leu Leu \par
        275                 280                 285             \par
Met Tyr Ser His Asp Asn Ile Ile Cys Gly Ile Thr Ser Val Ala Phe \par
    290                 295                 300                 \par
Ser Arg Ser Gly Arg Leu Leu Leu Ala Gly Tyr Asp Asp Phe Asn Cys \par
305                 310                 315                 320 \par
Asn Ile Trp Asp Ala Met Lys Gly Asp Arg Ala Gly Val Leu Ala Gly \par
                325                 330                 335     \par
His Asp Asn Arg Val Ser Cys Leu Gly Val Thr Asp Asp Gly Met Ala \par
            340                 345                 350         \par
Val Ala Thr Gly Ser Trp Asp Ser Phe Leu Lys Ile Trp Asn \par
        355                 360                 365     \par
\par
<210> 18\par
<211> 366\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b23 (SmBiT-GNB3)\par
\par
<400> 18\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Gly Glu Met Glu Gln \par
            20                  25                  30          \par
Leu Arg Gln Glu Ala Glu Gln Leu Lys Lys Gln Ile Ala Asp Ala Arg \par
        35                  40                  45              \par
Lys Ala Cys Ala Asp Val Thr Leu Ala Glu Leu Val Ser Gly Leu Glu \par
    50                  55                  60                  \par
Val Val Gly Arg Val Gln Met Arg Thr Arg Arg Thr Leu Arg Gly His \par
65                  70                  75                  80  \par
Leu Ala Lys Ile Tyr Ala Met His Trp Ala Thr Asp Ser Lys Leu Leu \par
                85                  90                  95      \par
Val Ser Ala Ser Gln Asp Gly Lys Leu Ile Val Trp Asp Ser Tyr Thr \par
            100                 105                 110         \par
Thr Asn Lys Val His Ala Ile Pro Leu Arg Ser Ser Trp Val Met Thr \par
        115                 120                 125             \par
Cys Ala Tyr Ala Pro Ser Gly Asn Phe Val Ala Cys Gly Gly Leu Asp \par
    130                 135                 140                 \par
Asn Met Cys Ser Ile Tyr Asn Leu Lys Ser Arg Glu Gly Asn Val Lys \par
145                 150                 155                 160 \par
Val Ser Arg Glu Leu Ser Ala His Thr Gly Tyr Leu Ser Cys Cys Arg \par
                165                 170                 175     \par
Phe Leu Asp Asp Asn Asn Ile Val Thr Ser Ser Gly Asp Thr Thr Cys \par
            180                 185                 190         \par
Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln Lys Thr Val Phe Val Gly \par
        195                 200                 205             \par
His Thr Gly Asp Cys Met Ser Leu Ala Val Ser Pro Asp Phe Asn Leu \par
    210                 215                 220                 \par
Phe Ile Ser Gly Ala Cys Asp Ala Ser Ala Lys Leu Trp Asp Val Arg \par
225                 230                 235                 240 \par
Glu Gly Thr Cys Arg Gln Thr Phe Thr Gly His Glu Ser Asp Ile Asn \par
                245                 250                 255     \par
Ala Ile Cys Phe Phe Pro Asn Gly Glu Ala Ile Cys Thr Gly Ser Asp \par
            260                 265                 270         \par
Asp Ala Ser Cys Arg Leu Phe Asp Leu Arg Ala Asp Gln Glu Leu Ile \par
        275                 280                 285             \par
Cys Phe Ser His Glu Ser Ile Ile Cys Gly Ile Thr Ser Val Ala Phe \par
    290                 295                 300                 \par
Ser Leu Ser Gly Arg Leu Leu Phe Ala Gly Tyr Asp Asp Phe Asn Cys \par
305                 310                 315                 320 \par
Asn Val Trp Asp Ser Met Lys Ser Glu Arg Val Gly Ile Leu Ser Gly \par
                325                 330                 335     \par
His Asp Asn Arg Val Ser Cys Leu Gly Val Thr Ala Asp Gly Met Ala \par
            340                 345                 350         \par
Val Ala Thr Gly Ser Trp Asp Ser Phe Leu Lys Ile Trp Asn \par
        355                 360                 365     \par
\par
<210> 19\par
<211> 366\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b24 (SmBiT-GNB4)\par
\par
<400> 19\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Glu Leu Glu Gln \par
            20                  25                  30          \par
Leu Arg Gln Glu Ala Glu Gln Leu Arg Asn Gln Ile Gln Asp Ala Arg \par
        35                  40                  45              \par
Lys Ala Cys Asn Asp Ala Thr Leu Val Gln Ile Thr Ser Asn Met Asp \par
    50                  55                  60                  \par
Ser Val Gly Arg Ile Gln Met Arg Thr Arg Arg Thr Leu Arg Gly His \par
65                  70                  75                  80  \par
Leu Ala Lys Ile Tyr Ala Met His Trp Gly Tyr Asp Ser Arg Leu Leu \par
                85                  90                  95      \par
Val Ser Ala Ser Gln Asp Gly Lys Leu Ile Ile Trp Asp Ser Tyr Thr \par
            100                 105                 110         \par
Thr Asn Lys Met His Ala Ile Pro Leu Arg Ser Ser Trp Val Met Thr \par
        115                 120                 125             \par
Cys Ala Tyr Ala Pro Ser Gly Asn Tyr Val Ala Cys Gly Gly Leu Asp \par
    130                 135                 140                 \par
Asn Ile Cys Ser Ile Tyr Asn Leu Lys Thr Arg Glu Gly Asn Val Arg \par
145                 150                 155                 160 \par
Val Ser Arg Glu Leu Pro Gly His Thr Gly Tyr Leu Ser Cys Cys Arg \par
                165                 170                 175     \par
Phe Leu Asp Asp Ser Gln Ile Val Thr Ser Ser Gly Asp Thr Thr Cys \par
            180                 185                 190         \par
Ala Leu Trp Asp Ile Glu Thr Ala Gln Gln Thr Thr Thr Phe Thr Gly \par
        195                 200                 205             \par
His Ser Gly Asp Val Met Ser Leu Ser Leu Ser Pro Asp Met Arg Thr \par
    210                 215                 220                 \par
Phe Val Ser Gly Ala Cys Asp Ala Ser Ser Lys Leu Trp Asp Ile Arg \par
225                 230                 235                 240 \par
Asp Gly Met Cys Arg Gln Ser Phe Thr Gly His Val Ser Asp Ile Asn \par
                245                 250                 255     \par
Ala Val Ser Phe Phe Pro Asn Gly Tyr Ala Phe Ala Thr Gly Ser Asp \par
            260                 265                 270         \par
Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg Ala Asp Gln Glu Leu Leu \par
        275                 280                 285             \par
Leu Tyr Ser His Asp Asn Ile Ile Cys Gly Ile Thr Ser Val Ala Phe \par
    290                 295                 300                 \par
Ser Lys Ser Gly Arg Leu Leu Leu Ala Gly Tyr Asp Asp Phe Asn Cys \par
305                 310                 315                 320 \par
Asn Val Trp Asp Thr Leu Lys Gly Asp Arg Ala Gly Val Leu Ala Gly \par
                325                 330                 335     \par
His Asp Asn Arg Val Ser Cys Leu Gly Val Thr Asp Asp Gly Met Ala \par
            340                 345                 350         \par
Val Ala Thr Gly Ser Trp Asp Ser Phe Leu Arg Ile Trp Asn \par
        355                 360                 365     \par
\par
<210> 20\par
<211> 421\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b25 (SmBiT-GNB5)\par
\par
<400> 20\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Cys Asp Gln Thr Phe \par
            20                  25                  30          \par
Leu Val Asn Val Phe Gly Ser Cys Asp Lys Cys Phe Lys Gln Arg Ala \par
        35                  40                  45              \par
Leu Arg Pro Val Phe Lys Lys Ser Gln Gln Leu Ser Tyr Cys Ser Thr \par
    50                  55                  60                  \par
Cys Ala Glu Ile Met Ala Thr Glu Gly Leu His Glu Asn Glu Thr Leu \par
65                  70                  75                  80  \par
Ala Ser Leu Lys Ser Glu Ala Glu Ser Leu Lys Gly Lys Leu Glu Glu \par
                85                  90                  95      \par
Glu Arg Ala Lys Leu His Asp Val Glu Leu His Gln Val Ala Glu Arg \par
            100                 105                 110         \par
Val Glu Ala Leu Gly Gln Phe Val Met Lys Thr Arg Arg Thr Leu Lys \par
        115                 120                 125             \par
Gly His Gly Asn Lys Val Leu Cys Met Asp Trp Cys Lys Asp Lys Arg \par
    130                 135                 140                 \par
Arg Ile Val Ser Ser Ser Gln Asp Gly Lys Val Ile Val Trp Asp Ser \par
145                 150                 155                 160 \par
Phe Thr Thr Asn Lys Glu His Ala Val Thr Met Pro Cys Thr Trp Val \par
                165                 170                 175     \par
Met Ala Cys Ala Tyr Ala Pro Ser Gly Cys Ala Ile Ala Cys Gly Gly \par
            180                 185                 190         \par
Leu Asp Asn Lys Cys Ser Val Tyr Pro Leu Thr Phe Asp Lys Asn Glu \par
        195                 200                 205             \par
Asn Met Ala Ala Lys Lys Lys Ser Val Ala Met His Thr Asn Tyr Leu \par
    210                 215                 220                 \par
Ser Ala Cys Ser Phe Thr Asn Ser Asp Met Gln Ile Leu Thr Ala Ser \par
225                 230                 235                 240 \par
Gly Asp Gly Thr Cys Ala Leu Trp Asp Val Glu Ser Gly Gln Leu Leu \par
                245                 250                 255     \par
Gln Ser Phe His Gly His Gly Ala Asp Val Leu Cys Leu Asp Leu Ala \par
            260                 265                 270         \par
Pro Ser Glu Thr Gly Asn Thr Phe Val Ser Gly Gly Cys Asp Lys Lys \par
        275                 280                 285             \par
Ala Met Val Trp Asp Met Arg Ser Gly Gln Cys Val Gln Ala Phe Glu \par
    290                 295                 300                 \par
Thr His Glu Ser Asp Ile Asn Ser Val Arg Tyr Tyr Pro Ser Gly Asp \par
305                 310                 315                 320 \par
Ala Phe Ala Ser Gly Ser Asp Asp Ala Thr Cys Arg Leu Tyr Asp Leu \par
                325                 330                 335     \par
Arg Ala Asp Arg Glu Val Ala Ile Tyr Ser Lys Glu Ser Ile Ile Phe \par
            340                 345                 350         \par
Gly Ala Ser Ser Val Asp Phe Ser Leu Ser Gly Arg Leu Leu Phe Ala \par
        355                 360                 365             \par
Gly Tyr Asn Asp Tyr Thr Ile Asn Val Trp Asp Val Leu Lys Gly Ser \par
    370                 375                 380                 \par
Arg Val Ser Ile Leu Phe Gly His Glu Asn Arg Val Ser Thr Leu Arg \par
385                 390                 395                 400 \par
Val Ser Pro Asp Gly Thr Ala Phe Cys Ser Gly Ser Trp Asp His Thr \par
                405                 410                 415     \par
Leu Arg Val Trp Ala \par
            420     \par
\par
<210> 21\par
<211> 97\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b32 (SmBiT-GNG2)\par
\par
<400> 21\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Ser Asn Asn Thr \par
            20                  25                  30          \par
Ala Ser Ile Ala Gln Ala Arg Lys Leu Val Glu Gln Leu Lys Met Glu \par
        35                  40                  45              \par
Ala Asn Ile Asp Arg Ile Lys Val Ser Lys Ala Ala Ala Asp Leu Met \par
    50                  55                  60                  \par
Ala Tyr Cys Glu Ala His Ala Lys Glu Asp Pro Leu Leu Thr Pro Val \par
65                  70                  75                  80  \par
Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys Lys Phe Phe Cys Ala Ile \par
                85                  90                  95      \par
Leu \par
    \par
\par
<210> 22\par
<211> 101\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b33 (SmBiT-GNG3)\par
\par
<400> 22\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Lys Gly Glu Thr Pro \par
            20                  25                  30          \par
Val Asn Ser Thr Met Ser Ile Gly Gln Ala Arg Lys Met Val Glu Gln \par
        35                  40                  45              \par
Leu Lys Ile Glu Ala Ser Leu Cys Arg Ile Lys Val Ser Lys Ala Ala \par
    50                  55                  60                  \par
Ala Asp Leu Met Thr Tyr Cys Asp Ala His Ala Cys Glu Asp Pro Leu \par
65                  70                  75                  80  \par
Ile Thr Pro Val Pro Thr Ser Glu Asn Pro Phe Arg Glu Lys Lys Phe \par
                85                  90                  95      \par
Phe Cys Ala Leu Leu \par
            100     \par
\par
<210> 23\par
<211> 101\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b34 (SmBiT-GNG4)\par
\par
<400> 23\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Lys Glu Gly Met Ser \par
            20                  25                  30          \par
Asn Asn Ser Thr Thr Ser Ile Ser Gln Ala Arg Lys Ala Val Glu Gln \par
        35                  40                  45              \par
Leu Lys Met Glu Ala Cys Met Asp Arg Val Lys Val Ser Gln Ala Ala \par
    50                  55                  60                  \par
Ala Asp Leu Leu Ala Tyr Cys Glu Ala His Val Arg Glu Asp Pro Leu \par
65                  70                  75                  80  \par
Ile Ile Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys Lys Phe \par
                85                  90                  95      \par
Phe Cys Thr Ile Leu \par
            100     \par
\par
<210> 24\par
<211> 94\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b35 (SmBiT-GNG5)\par
\par
<400> 24\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Gly Ser Ser Ser \par
            20                  25                  30          \par
Val Ala Ala Met Lys Lys Val Val Gln Gln Leu Arg Leu Glu Ala Gly \par
        35                  40                  45              \par
Leu Asn Arg Val Lys Val Ser Gln Ala Ala Ala Asp Leu Lys Gln Phe \par
    50                  55                  60                  \par
Cys Leu Gln Asn Ala Gln His Asp Pro Leu Leu Thr Gly Val Ser Ser \par
65                  70                  75                  80  \par
Ser Thr Asn Pro Phe Arg Pro Gln Lys Val Cys Ser Phe Leu \par
                85                  90                  \par
\par
<210> 25\par
<211> 94\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b37 (SmBiT-GNG7)\par
\par
<400> 25\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Ala Thr Asn Asn \par
            20                  25                  30          \par
Ile Ala Gln Ala Arg Lys Leu Val Glu Gln Leu Arg Ile Glu Ala Gly \par
        35                  40                  45              \par
Ile Glu Arg Ile Lys Val Ser Lys Ala Ala Ser Asp Leu Met Ser Tyr \par
    50                  55                  60                  \par
Cys Glu Gln His Ala Arg Asn Asp Pro Leu Leu Val Gly Val Pro Ala \par
65                  70                  75                  80  \par
Ser Glu Asn Pro Phe Lys Asp Lys Lys Pro Cys Ile Ile Leu \par
                85                  90                  \par
\par
<210> 26\par
<211> 96\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b38 (SmBiT-GNG8)\par
\par
<400> 26\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Asn Asn Met Ala \par
            20                  25                  30          \par
Lys Ile Ala Glu Ala Arg Lys Thr Val Glu Gln Leu Lys Leu Glu Val \par
        35                  40                  45              \par
Asn Ile Asp Arg Met Lys Val Ser Gln Ala Ala Ala Glu Leu Leu Ala \par
    50                  55                  60                  \par
Phe Cys Glu Thr His Ala Lys Asp Asp Pro Leu Val Thr Pro Val Pro \par
65                  70                  75                  80  \par
Ala Ala Glu Asn Pro Phe Arg Asp Lys Arg Leu Phe Cys Val Leu Leu \par
                85                  90                  95      \par
\par
\par
\par
<210> 27\par
<211> 94\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b310 (SmBiT-GNG10)\par
\par
<400> 27\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Ser Gly Ala Ser \par
            20                  25                  30          \par
Ala Ser Ala Leu Gln Arg Leu Val Glu Gln Leu Lys Leu Glu Ala Gly \par
        35                  40                  45              \par
Val Glu Arg Ile Lys Val Ser Gln Ala Ala Ala Glu Leu Gln Gln Tyr \par
    50                  55                  60                  \par
Cys Met Gln Asn Ala Cys Lys Asp Ala Leu Leu Val Gly Val Pro Ala \par
65                  70                  75                  80  \par
Gly Ser Asn Pro Phe Arg Glu Pro Arg Ser Cys Ala Leu Leu \par
                85                  90                  \par
\par
<210> 28\par
<211> 99\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b311 (SmBiT-GNG11)\par
\par
<400> 28\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Pro Ala Leu His Ile \par
            20                  25                  30          \par
Glu Asp Leu Pro Glu Lys Glu Lys Leu Lys Met Glu Val Glu Gln Leu \par
        35                  40                  45              \par
Arg Lys Glu Val Lys Leu Gln Arg Gln Gln Val Ser Lys Cys Ser Glu \par
    50                  55                  60                  \par
Glu Ile Lys Asn Tyr Ile Glu Glu Arg Ser Gly Glu Asp Pro Leu Val \par
65                  70                  75                  80  \par
Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly Ser Cys \par
                85                  90                  95      \par
Val Ile Ser \par
            \par
\par
<210> 29\par
<211> 98\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b312 (SmBiT-GNG12)\par
\par
<400> 29\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Ser Lys Thr Ala \par
            20                  25                  30          \par
Ser Thr Asn Asn Ile Ala Gln Ala Arg Arg Thr Val Gln Gln Leu Arg \par
        35                  40                  45              \par
Leu Glu Ala Ser Ile Glu Arg Ile Lys Val Ser Lys Ala Ser Ala Asp \par
    50                  55                  60                  \par
Leu Met Ser Tyr Cys Glu Glu His Ala Arg Ser Asp Pro Leu Leu Ile \par
65                  70                  75                  80  \par
Gly Ile Pro Thr Ser Glu Asn Pro Phe Lys Asp Lys Lys Thr Cys Ile \par
                85                  90                  95      \par
Ile Leu \par
        \par
\par
<210> 30\par
<211> 93\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b313 (SmBiT-GNG13)\par
\par
<400> 30\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Glu Glu Trp Asp Val \par
            20                  25                  30          \par
Pro Gln Met Lys Lys Glu Val Glu Ser Leu Lys Tyr Gln Leu Ala Phe \par
        35                  40                  45              \par
Gln Arg Glu Met Ala Ser Lys Thr Ile Pro Glu Leu Leu Lys Trp Ile \par
    50                  55                  60                  \par
Glu Asp Gly Ile Pro Lys Asp Pro Phe Leu Asn Pro Asp Leu Met Lys \par
65                  70                  75                  80  \par
Asn Asn Pro Trp Val Glu Lys Gly Lys Cys Thr Ile Leu \par
                85                  90              \par
\par
<210> 31\par
<211> 100\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b3t1 (SmBiT-GNGT1)\par
\par
<400> 31\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Pro Val Ile Asn Ile \par
            20                  25                  30          \par
Glu Asp Leu Thr Glu Lys Asp Lys Leu Lys Met Glu Val Asp Gln Leu \par
        35                  40                  45              \par
Lys Lys Glu Val Thr Leu Glu Arg Met Leu Val Ser Lys Cys Cys Glu \par
    50                  55                  60                  \par
Glu Val Arg Asp Tyr Val Glu Glu Arg Ser Gly Glu Asp Pro Leu Val \par
65                  70                  75                  80  \par
Lys Gly Ile Pro Glu Asp Lys Asn Pro Phe Lys Glu Leu Lys Gly Gly \par
                85                  90                  95      \par
Cys Val Ile Ser \par
            100 \par
\par
<210> 32\par
<211> 95\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b3 (SmBiT-GNGT2)\par
\par
<400> 32\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Gln Asp Leu Ser \par
            20                  25                  30          \par
Glu Lys Asp Leu Leu Lys Met Glu Val Glu Gln Leu Lys Lys Glu Val \par
        35                  40                  45              \par
Lys Asn Thr Arg Ile Pro Ile Ser Lys Ala Gly Lys Glu Ile Lys Glu \par
    50                  55                  60                  \par
Tyr Val Glu Ala Gln Ala Gly Asn Asp Pro Phe Leu Lys Gly Ile Pro \par
65                  70                  75                  80  \par
Glu Asp Lys Asn Pro Phe Lys Glu Lys Gly Gly Cys Leu Ile Ser \par
                85                  90                  95  \par
\par
<210> 33\par
<211> 435\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s-Sm (GNAS-SmBiT)\par
\par
<400> 33\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala \par
65                  70                  75                  80  \par
Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys \par
                85                  90                  95      \par
Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn \par
            100                 105                 110         \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
        115                 120                 125             \par
Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly Gly \par
    130                 135                 140                 \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Pro Pro Val Glu Leu \par
145                 150                 155                 160 \par
Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu Ser Val Met \par
                165                 170                 175     \par
Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu His Ala Lys \par
            180                 185                 190         \par
Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg Ser Asn \par
        195                 200                 205             \par
Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys Ile Asp \par
    210                 215                 220                 \par
Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg \par
225                 230                 235                 240 \par
Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp \par
                245                 250                 255     \par
Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg Asp Glu Arg \par
            260                 265                 270         \par
Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile Ile Phe Val \par
        275                 280                 285             \par
Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp Asn Gln Thr \par
    290                 295                 300                 \par
Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp Asn Asn \par
305                 310                 315                 320 \par
Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn Lys Gln Asp \par
                325                 330                 335     \par
Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile Glu Asp Tyr \par
            340                 345                 350         \par
Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr Pro Glu \par
        355                 360                 365             \par
Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile Arg Asp \par
    370                 375                 380                 \par
Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg His Tyr Cys \par
385                 390                 395                 400 \par
Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile Arg Arg Val \par
                405                 410                 415     \par
Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu Arg Gln Tyr \par
            420                 425                 430         \par
Glu Leu Leu \par
        435 \par
\par
<210> 34\par
<211> 568\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s-Lg (\'ce\'b1B-\'ce\'b1C) (GNAS-LgBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 34\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Gly Gly \par
        115                 120                 125             \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr \par
    130                 135                 140                 \par
Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu \par
145                 150                 155                 160 \par
Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu \par
                165                 170                 175     \par
Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn \par
            180                 185                 190         \par
Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser \par
        195                 200                 205             \par
Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro \par
    210                 215                 220                 \par
Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val \par
225                 230                 235                 240 \par
Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr \par
                245                 250                 255     \par
Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr \par
            260                 265                 270         \par
Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp \par
        275                 280                 285             \par
Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly \par
    290                 295                 300                 \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Asp Phe Pro Pro Glu Phe \par
305                 310                 315                 320 \par
Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys \par
                325                 330                 335     \par
Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe \par
            340                 345                 350         \par
Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp \par
        355                 360                 365             \par
Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr \par
    370                 375                 380                 \par
Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly \par
385                 390                 395                 400 \par
Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr \par
                405                 410                 415     \par
Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg \par
            420                 425                 430         \par
Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys \par
        435                 440                 445             \par
Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe \par
    450                 455                 460                 \par
Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser \par
465                 470                 475                 480 \par
Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu \par
                485                 490                 495     \par
Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys \par
            500                 505                 510         \par
Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp \par
        515                 520                 525             \par
Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu \par
    530                 535                 540                 \par
Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met \par
545                 550                 555                 560 \par
His Leu Arg Gln Tyr Glu Leu Leu \par
                565             \par
\par
<210> 35\par
<211> 421\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s-Sm (\'ce\'b1B-\'ce\'b1C) (GNAS-SmBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 35\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Gly Gly \par
        115                 120                 125             \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Thr Gly \par
    130                 135                 140                 \par
Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly Gly Gly Gly Ser \par
145                 150                 155                 160 \par
Gly Gly Ser Ser Ser Gly Gly Asp Phe Pro Pro Glu Phe Tyr Glu His \par
                165                 170                 175     \par
Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu Arg \par
            180                 185                 190         \par
Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp Lys \par
        195                 200                 205             \par
Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu \par
    210                 215                 220                 \par
Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln \par
225                 230                 235                 240 \par
Val Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg Asp \par
                245                 250                 255     \par
Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile Ile \par
            260                 265                 270         \par
Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp Asn \par
        275                 280                 285             \par
Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile Trp \par
    290                 295                 300                 \par
Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn Lys \par
305                 310                 315                 320 \par
Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile Glu \par
                325                 330                 335     \par
Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala Thr \par
            340                 345                 350         \par
Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe Ile \par
        355                 360                 365             \par
Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg His \par
    370                 375                 380                 \par
Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile Arg \par
385                 390                 395                 400 \par
Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu Arg \par
                405                 410                 415     \par
Gln Tyr Glu Leu Leu \par
            420     \par
\par
<210> 36\par
<211> 582\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s-Lg (G2A/C3S) (GNAS-LgBiT-G2A-C3S)\par
\par
<400> 36\par
Met Ala Ser Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala \par
65                  70                  75                  80  \par
Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys \par
                85                  90                  95      \par
Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn \par
            100                 105                 110         \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
        115                 120                 125             \par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
    130                 135                 140                 \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
145                 150                 155                 160 \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
                165                 170                 175     \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
            180                 185                 190         \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
        195                 200                 205             \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
    210                 215                 220                 \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
225                 230                 235                 240 \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
                245                 250                 255     \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
            260                 265                 270         \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly \par
        275                 280                 285             \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Pro Pro \par
    290                 295                 300                 \par
Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val Asp Tyr Ile Leu \par
305                 310                 315                 320 \par
Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro Glu Phe Tyr Glu \par
                325                 330                 335     \par
His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg Ala Cys Tyr Glu \par
            340                 345                 350         \par
Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln Tyr Phe Leu Asp \par
        355                 360                 365             \par
Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp \par
    370                 375                 380                 \par
Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe \par
385                 390                 395                 400 \par
Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val Gly Gly Gln Arg \par
                405                 410                 415     \par
Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp Val Thr Ala Ile \par
            420                 425                 430         \par
Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val Ile Arg Glu Asp \par
        435                 440                 445             \par
Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu Phe Lys Ser Ile \par
    450                 455                 460                 \par
Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile Leu Phe Leu Asn \par
465                 470                 475                 480 \par
Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly Lys Ser Lys Ile \par
                485                 490                 495     \par
Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr Pro Glu Asp Ala \par
            500                 505                 510         \par
Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg Ala Lys Tyr Phe \par
        515                 520                 525             \par
Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser Gly Asp Gly Arg \par
    530                 535                 540                 \par
His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp Thr Glu Asn Ile \par
545                 550                 555                 560 \par
Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln Arg Met His Leu \par
                565                 570                 575     \par
Arg Gln Tyr Glu Leu Leu \par
            580         \par
\par
<210> 37\par
<211> 547\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q-Lg (R183C) (GNAQ-LgBiT-R183C)\par
\par
<400> 37\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
            100                 105                 110         \par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
        115                 120                 125             \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
    130                 135                 140                 \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
145                 150                 155                 160 \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
                165                 170                 175     \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
            180                 185                 190         \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
        195                 200                 205             \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
    210                 215                 220                 \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
225                 230                 235                 240 \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
                245                 250                 255     \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly \par
            260                 265                 270         \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Lys Ile Pro \par
        275                 280                 285             \par
Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu Val Arg Glu Val \par
    290                 295                 300                 \par
Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr Val Asp Ala Ile \par
305                 310                 315                 320 \par
Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg \par
                325                 330                 335     \par
Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu \par
            340                 345                 350         \par
Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu \par
        355                 360                 365             \par
Arg Val Cys Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu \par
    370                 375                 380                 \par
Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu \par
385                 390                 395                 400 \par
Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe \par
                405                 410                 415     \par
Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn \par
            420                 425                 430         \par
Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr \par
        435                 440                 445             \par
Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys \par
    450                 455                 460                 \par
Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe \par
465                 470                 475                 480 \par
Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe \par
                485                 490                 495     \par
Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile \par
            500                 505                 510         \par
Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val \par
        515                 520                 525             \par
Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr \par
    530                 535                 540                 \par
Asn Leu Val \par
545         \par
\par
<210> 38\par
<211> 547\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q-Lg (\'ce\'b1B-\'ce\'b1C) (GNAQ-LgBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 38\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Gly Gly Ser Gly Gly \par
        115                 120                 125             \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
    130                 135                 140                 \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
145                 150                 155                 160 \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
                165                 170                 175     \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
            180                 185                 190         \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
        195                 200                 205             \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
    210                 215                 220                 \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
225                 230                 235                 240 \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
                245                 250                 255     \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
            260                 265                 270         \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
        275                 280                 285             \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
    290                 295                 300                 \par
Gly Gly Ser Ser Ser Gly Gly Phe Glu Asn Pro Tyr Val Asp Ala Ile \par
305                 310                 315                 320 \par
Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg \par
                325                 330                 335     \par
Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr Leu Asn Asp Leu \par
            340                 345                 350         \par
Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln Gln Asp Val Leu \par
        355                 360                 365             \par
Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu \par
    370                 375                 380                 \par
Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu \par
385                 390                 395                 400 \par
Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe \par
                405                 410                 415     \par
Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn \par
            420                 425                 430         \par
Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr \par
        435                 440                 445             \par
Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys \par
    450                 455                 460                 \par
Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu Val Asp Tyr Phe \par
465                 470                 475                 480 \par
Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe \par
                485                 490                 495     \par
Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile \par
            500                 505                 510         \par
Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val \par
        515                 520                 525             \par
Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr \par
    530                 535                 540                 \par
Asn Leu Val \par
545         \par
\par
<210> 39\par
<211> 547\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b111-Lg (\'ce\'b1B-\'ce\'b1C) (GNA11-LgBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 39\par
Met Thr Leu Glu Ser Met Met Ala Cys Cys Leu Ser Asp Glu Val Lys \par
1               5                   10                  15      \par
Glu Ser Lys Arg Ile Asn Ala Glu Ile Glu Lys Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ala Gly Tyr Ser Glu Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Glu Thr \par
                85                  90                  95      \par
Leu Lys Ile Leu Tyr Lys Tyr Glu Gln Asn Lys Ala Asn Ala Leu Leu \par
            100                 105                 110         \par
Ile Arg Glu Val Asp Val Glu Lys Val Thr Thr Gly Gly Ser Gly Gly \par
        115                 120                 125             \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp \par
    130                 135                 140                 \par
Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val \par
145                 150                 155                 160 \par
Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser \par
                165                 170                 175     \par
Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys \par
            180                 185                 190         \par
Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln \par
        195                 200                 205             \par
Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp \par
    210                 215                 220                 \par
His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly \par
225                 230                 235                 240 \par
Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile \par
                245                 250                 255     \par
Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn \par
            260                 265                 270         \par
Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met \par
        275                 280                 285             \par
Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser \par
    290                 295                 300                 \par
Gly Gly Ser Ser Ser Gly Gly Phe Glu His Gln Tyr Val Ser Ala Ile \par
305                 310                 315                 320 \par
Lys Thr Leu Trp Glu Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg \par
                325                 330                 335     \par
Arg Glu Tyr Gln Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Val \par
            340                 345                 350         \par
Asp Arg Ile Ala Thr Leu Gly Tyr Leu Pro Thr Gln Gln Asp Val Leu \par
        355                 360                 365             \par
Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu \par
    370                 375                 380                 \par
Glu Asn Ile Ile Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu \par
385                 390                 395                 400 \par
Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr Ser Ile Met Phe \par
                405                 410                 415     \par
Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val Glu Ser Asp Asn \par
            420                 425                 430         \par
Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg Thr Ile Ile Thr \par
        435                 440                 445             \par
Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys \par
    450                 455                 460                 \par
Asp Leu Leu Glu Asp Lys Ile Leu Tyr Ser His Leu Val Asp Tyr Phe \par
465                 470                 475                 480 \par
Pro Glu Phe Asp Gly Pro Gln Arg Asp Ala Gln Ala Ala Arg Glu Phe \par
                485                 490                 495     \par
Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser Asp Lys Ile Ile \par
            500                 505                 510         \par
Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn Ile Arg Phe Val \par
        515                 520                 525             \par
Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn Leu Lys Glu Tyr \par
    530                 535                 540                 \par
Asn Leu Val \par
545         \par
\par
<210> 40\par
<211> 543\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b114-Lg (\'ce\'b1B-\'ce\'b1C) (GNA14-LgBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 40\par
Met Ala Gly Cys Cys Cys Leu Ser Ala Glu Glu Lys Glu Ser Gln Arg \par
1               5                   10                  15      \par
Ile Ser Ala Glu Ile Glu Arg Gln Leu Arg Arg Asp Lys Lys Asp Ala \par
            20                  25                  30          \par
Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly Glu Ser Gly Lys \par
        35                  40                  45              \par
Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly Ser Gly Tyr Ser \par
    50                  55                  60                  \par
Asp Glu Asp Arg Lys Gly Phe Thr Lys Leu Val Tyr Gln Asn Ile Phe \par
65                  70                  75                  80  \par
Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr Leu Arg Ile Gln \par
                85                  90                  95      \par
Tyr Val Cys Glu Gln Asn Lys Glu Asn Ala Gln Ile Ile Arg Glu Val \par
            100                 105                 110         \par
Glu Val Asp Lys Val Ser Met Gly Gly Ser Gly Gly Gly Gly Ser Gly \par
        115                 120                 125             \par
Gly Ser Ser Ser Gly Gly Val Phe Thr Leu Glu Asp Phe Val Gly Asp \par
    130                 135                 140                 \par
Trp Glu Gln Thr Ala Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly \par
145                 150                 155                 160 \par
Gly Val Ser Ser Leu Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile \par
                165                 170                 175     \par
Gln Arg Ile Val Arg Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His \par
            180                 185                 190         \par
Val Ile Ile Pro Tyr Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile \par
        195                 200                 205             \par
Glu Glu Val Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys \par
    210                 215                 220                 \par
Val Ile Leu Pro Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn \par
225                 230                 235                 240 \par
Met Leu Asn Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp \par
                245                 250                 255     \par
Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile \par
            260                 265                 270         \par
Ile Asp Glu Arg Leu Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val \par
        275                 280                 285             \par
Thr Ile Asn Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser \par
    290                 295                 300                 \par
Ser Gly Gly Leu Ser Arg Glu Gln Val Glu Ala Ile Lys Gln Leu Trp \par
305                 310                 315                 320 \par
Gln Asp Pro Gly Ile Gln Glu Cys Tyr Asp Arg Arg Arg Glu Tyr Gln \par
                325                 330                 335     \par
Leu Ser Asp Ser Ala Lys Tyr Tyr Leu Thr Asp Ile Asp Arg Ile Ala \par
            340                 345                 350         \par
Thr Pro Ser Phe Val Pro Thr Gln Gln Asp Val Leu Arg Val Arg Val \par
        355                 360                 365             \par
Pro Thr Thr Gly Ile Ile Glu Tyr Pro Phe Asp Leu Glu Asn Ile Ile \par
    370                 375                 380                 \par
Phe Arg Met Val Asp Val Gly Gly Gln Arg Ser Glu Arg Arg Lys Trp \par
385                 390                 395                 400 \par
Ile His Cys Phe Glu Ser Val Thr Ser Ile Ile Phe Leu Val Ala Leu \par
                405                 410                 415     \par
Ser Glu Tyr Asp Gln Val Leu Ala Glu Cys Asp Asn Glu Asn Arg Met \par
            420                 425                 430         \par
Glu Glu Ser Lys Ala Leu Phe Lys Thr Ile Ile Thr Tyr Pro Trp Phe \par
        435                 440                 445             \par
Leu Asn Ser Ser Val Ile Leu Phe Leu Asn Lys Lys Asp Leu Leu Glu \par
    450                 455                 460                 \par
Glu Lys Ile Met Tyr Ser His Leu Ile Ser Tyr Phe Pro Glu Tyr Thr \par
465                 470                 475                 480 \par
Gly Pro Lys Gln Asp Val Arg Ala Ala Arg Asp Phe Ile Leu Lys Leu \par
                485                 490                 495     \par
Tyr Gln Asp Gln Asn Pro Asp Lys Glu Lys Val Ile Tyr Ser His Phe \par
            500                 505                 510         \par
Thr Cys Ala Thr Asp Thr Asp Asn Ile Arg Phe Val Phe Ala Ala Val \par
        515                 520                 525             \par
Lys Asp Thr Ile Leu Gln Leu Asn Leu Arg Glu Phe Asn Leu Val \par
    530                 535                 540             \par
\par
<210> 41\par
<211> 562\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b116-Lg (\'ce\'b1B-\'ce\'b1C) (GNA15-LgBiT-\'ce\'b1B-\'ce\'b1C)\par
\par
<400> 41\par
Met Ala Arg Ser Leu Thr Trp Arg Cys Cys Pro Trp Cys Leu Thr Glu \par
1               5                   10                  15      \par
Asp Glu Lys Ala Ala Ala Arg Val Asp Gln Glu Ile Asn Arg Ile Leu \par
            20                  25                  30          \par
Leu Glu Gln Lys Lys Gln Asp Arg Gly Glu Leu Lys Leu Leu Leu Leu \par
        35                  40                  45              \par
Gly Pro Gly Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile \par
    50                  55                  60                  \par
Ile His Gly Ala Gly Tyr Ser Glu Glu Glu Arg Lys Gly Phe Arg Pro \par
65                  70                  75                  80  \par
Leu Val Tyr Gln Asn Ile Phe Val Ser Met Arg Ala Met Ile Glu Ala \par
                85                  90                  95      \par
Met Glu Arg Leu Gln Ile Pro Phe Ser Arg Pro Glu Ser Lys His His \par
            100                 105                 110         \par
Ala Ser Leu Val Met Ser Gln Asp Pro Tyr Lys Val Thr Thr Gly Gly \par
        115                 120                 125             \par
Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Phe Thr \par
    130                 135                 140                 \par
Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala Tyr Asn Leu \par
145                 150                 155                 160 \par
Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu Gln Asn Leu \par
                165                 170                 175     \par
Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser Gly Glu Asn \par
            180                 185                 190         \par
Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser \par
        195                 200                 205             \par
Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val Val Tyr Pro \par
    210                 215                 220                 \par
Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly Thr Leu Val \par
225                 230                 235                 240 \par
Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly Arg Pro Tyr \par
                245                 250                 255     \par
Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr \par
            260                 265                 270         \par
Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Thr Pro Asp \par
        275                 280                 285             \par
Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly Gly Ser Gly Gly \par
    290                 295                 300                 \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Phe Glu Lys Arg Tyr Ala \par
305                 310                 315                 320 \par
Ala Ala Met Gln Trp Leu Trp Arg Asp Ala Gly Ile Arg Ala Tyr Tyr \par
                325                 330                 335     \par
Glu Arg Arg Arg Glu Phe His Leu Leu Asp Ser Ala Val Tyr Tyr Leu \par
            340                 345                 350         \par
Ser His Leu Glu Arg Ile Thr Glu Glu Gly Tyr Val Pro Thr Ala Gln \par
        355                 360                 365             \par
Asp Val Leu Arg Ser Arg Met Pro Thr Thr Gly Ile Asn Glu Tyr Cys \par
    370                 375                 380                 \par
Phe Ser Val Gln Lys Thr Asn Leu Arg Ile Val Asp Val Gly Gly Gln \par
385                 390                 395                 400 \par
Lys Ser Glu Arg Lys Lys Trp Ile His Cys Phe Glu Asn Val Ile Ala \par
                405                 410                 415     \par
Leu Ile Tyr Leu Ala Ser Leu Ser Glu Tyr Asp Gln Cys Leu Glu Glu \par
            420                 425                 430         \par
Asn Asn Gln Glu Asn Arg Met Lys Glu Ser Leu Ala Leu Phe Gly Thr \par
        435                 440                 445             \par
Ile Leu Glu Leu Pro Trp Phe Lys Ser Thr Ser Val Ile Leu Phe Leu \par
    450                 455                 460                 \par
Asn Lys Thr Asp Ile Leu Glu Glu Lys Ile Pro Thr Ser His Leu Ala \par
465                 470                 475                 480 \par
Thr Tyr Phe Pro Ser Phe Gln Gly Pro Lys Gln Asp Ala Glu Ala Ala \par
                485                 490                 495     \par
Lys Arg Phe Ile Leu Asp Met Tyr Thr Arg Met Tyr Thr Gly Cys Val \par
            500                 505                 510         \par
Asp Gly Pro Glu Gly Ser Lys Lys Gly Ala Arg Ser Arg Arg Leu Phe \par
        515                 520                 525             \par
Ser His Tyr Thr Cys Ala Thr Asp Thr Gln Asn Ile Arg Lys Val Phe \par
    530                 535                 540                 \par
Lys Asp Val Arg Asp Ser Val Leu Ala Arg Tyr Leu Asp Glu Ile Asn \par
545                 550                 555                 560 \par
Leu Leu \par
        \par
\par
<210> 42\par
<211> 513\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Lg-G\'ce\'b21 (LgBiT-GNB1)\par
\par
<400> 42\par
Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala \par
1               5                   10                  15      \par
Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu \par
            20                  25                  30          \par
Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg \par
        35                  40                  45              \par
Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr \par
    50                  55                  60                  \par
Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys \par
65                  70                  75                  80  \par
Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr \par
                85                  90                  95      \par
Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe \par
            100                 105                 110         \par
Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr \par
        115                 120                 125             \par
Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu \par
    130                 135                 140                 \par
Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly \par
145                 150                 155                 160 \par
Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Glu \par
                165                 170                 175     \par
Leu Asp Gln Leu Arg Gln Glu Ala Glu Gln Leu Lys Asn Gln Ile Arg \par
            180                 185                 190         \par
Asp Ala Arg Lys Ala Cys Ala Asp Ala Thr Leu Ser Gln Ile Thr Asn \par
        195                 200                 205             \par
Asn Ile Asp Pro Val Gly Arg Ile Gln Met Arg Thr Arg Arg Thr Leu \par
    210                 215                 220                 \par
Arg Gly His Leu Ala Lys Ile Tyr Ala Met His Trp Gly Thr Asp Ser \par
225                 230                 235                 240 \par
Arg Leu Leu Val Ser Ala Ser Gln Asp Gly Lys Leu Ile Ile Trp Asp \par
                245                 250                 255     \par
Ser Tyr Thr Thr Asn Lys Val His Ala Ile Pro Leu Arg Ser Ser Trp \par
            260                 265                 270         \par
Val Met Thr Cys Ala Tyr Ala Pro Ser Gly Asn Tyr Val Ala Cys Gly \par
        275                 280                 285             \par
Gly Leu Asp Asn Ile Cys Ser Ile Tyr Asn Leu Lys Thr Arg Glu Gly \par
    290                 295                 300                 \par
Asn Val Arg Val Ser Arg Glu Leu Ala Gly His Thr Gly Tyr Leu Ser \par
305                 310                 315                 320 \par
Cys Cys Arg Phe Leu Asp Asp Asn Gln Ile Val Thr Ser Ser Gly Asp \par
                325                 330                 335     \par
Thr Thr Cys Ala Leu Trp Asp Ile Glu Thr Gly Gln Gln Thr Thr Thr \par
            340                 345                 350         \par
Phe Thr Gly His Thr Gly Asp Val Met Ser Leu Ser Leu Ala Pro Asp \par
        355                 360                 365             \par
Thr Arg Leu Phe Val Ser Gly Ala Cys Asp Ala Ser Ala Lys Leu Trp \par
    370                 375                 380                 \par
Asp Val Arg Glu Gly Met Cys Arg Gln Thr Phe Thr Gly His Glu Ser \par
385                 390                 395                 400 \par
Asp Ile Asn Ala Ile Cys Phe Phe Pro Asn Gly Asn Ala Phe Ala Thr \par
                405                 410                 415     \par
Gly Ser Asp Asp Ala Thr Cys Arg Leu Phe Asp Leu Arg Ala Asp Gln \par
            420                 425                 430         \par
Glu Leu Met Thr Tyr Ser His Asp Asn Ile Ile Cys Gly Ile Thr Ser \par
        435                 440                 445             \par
Val Ser Phe Ser Lys Ser Gly Arg Leu Leu Leu Ala Gly Tyr Asp Asp \par
    450                 455                 460                 \par
Phe Asn Cys Asn Val Trp Asp Ala Leu Lys Ala Asp Arg Ala Gly Val \par
465                 470                 475                 480 \par
Leu Ala Gly His Asp Asn Arg Val Ser Cys Leu Gly Val Thr Asp Asp \par
                485                 490                 495     \par
Gly Met Ala Val Ala Thr Gly Ser Trp Asp Ser Phe Leu Lys Ile Trp \par
            500                 505                 510         \par
Asn \par
    \par
\par
<210> 43\par
<211> 244\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Lg-G\'ce\'b32 (LgBiT-GNG2)\par
\par
<400> 43\par
Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala \par
1               5                   10                  15      \par
Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu \par
            20                  25                  30          \par
Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg \par
        35                  40                  45              \par
Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr \par
    50                  55                  60                  \par
Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys \par
65                  70                  75                  80  \par
Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr \par
                85                  90                  95      \par
Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe \par
            100                 105                 110         \par
Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr \par
        115                 120                 125             \par
Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu \par
    130                 135                 140                 \par
Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly \par
145                 150                 155                 160 \par
Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Ser \par
                165                 170                 175     \par
Asn Asn Thr Ala Ser Ile Ala Gln Ala Arg Lys Leu Val Glu Gln Leu \par
            180                 185                 190         \par
Lys Met Glu Ala Asn Ile Asp Arg Ile Lys Val Ser Lys Ala Ala Ala \par
        195                 200                 205             \par
Asp Leu Met Ala Tyr Cys Glu Ala His Ala Lys Glu Asp Pro Leu Leu \par
    210                 215                 220                 \par
Thr Pro Val Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys Lys Phe Phe \par
225                 230                 235                 240 \par
Cys Ala Ile Leu \par
                \par
\par
<210> 44\par
<211> 97\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-G\'ce\'b32 (C68S) (SmBiT-GNG2-C68S)\par
\par
<400> 44\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Ser Asn Asn Thr \par
            20                  25                  30          \par
Ala Ser Ile Ala Gln Ala Arg Lys Leu Val Glu Gln Leu Lys Met Glu \par
        35                  40                  45              \par
Ala Asn Ile Asp Arg Ile Lys Val Ser Lys Ala Ala Ala Asp Leu Met \par
    50                  55                  60                  \par
Ala Tyr Cys Glu Ala His Ala Lys Glu Asp Pro Leu Leu Thr Pro Val \par
65                  70                  75                  80  \par
Pro Ala Ser Glu Asn Pro Phe Arg Glu Lys Lys Phe Phe Ser Ala Ile \par
                85                  90                  95      \par
Leu \par
    \par
\par
<210> 45\par
<211> 1242\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-PLC\'ce\'b21 (SmBiT-PLCB1)\par
\par
<400> 45\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Gly Ala Gln Pro \par
            20                  25                  30          \par
Gly Val His Ala Leu Gln Leu Lys Pro Val Cys Val Ser Asp Ser Leu \par
        35                  40                  45              \par
Lys Lys Gly Thr Lys Phe Val Lys Trp Asp Asp Asp Ser Thr Ile Val \par
    50                  55                  60                  \par
Thr Pro Ile Ile Leu Arg Thr Asp Pro Gln Gly Phe Phe Phe Tyr Trp \par
65                  70                  75                  80  \par
Thr Asp Gln Asn Lys Glu Thr Glu Leu Leu Asp Leu Ser Leu Val Lys \par
                85                  90                  95      \par
Asp Ala Arg Cys Gly Arg His Ala Lys Ala Pro Lys Asp Pro Lys Leu \par
            100                 105                 110         \par
Arg Glu Leu Leu Asp Val Gly Asn Ile Gly Arg Leu Glu Gln Arg Met \par
        115                 120                 125             \par
Ile Thr Val Val Tyr Gly Pro Asp Leu Val Asn Ile Ser His Leu Asn \par
    130                 135                 140                 \par
Leu Val Ala Phe Gln Glu Glu Val Ala Lys Glu Trp Thr Asn Glu Val \par
145                 150                 155                 160 \par
Phe Ser Leu Ala Thr Asn Leu Leu Ala Gln Asn Met Ser Arg Asp Ala \par
                165                 170                 175     \par
Phe Leu Glu Lys Ala Tyr Thr Lys Leu Lys Leu Gln Val Thr Pro Glu \par
            180                 185                 190         \par
Gly Arg Ile Pro Leu Lys Asn Ile Tyr Arg Leu Phe Ser Ala Asp Arg \par
        195                 200                 205             \par
Lys Arg Val Glu Thr Ala Leu Glu Ala Cys Ser Leu Pro Ser Ser Arg \par
    210                 215                 220                 \par
Asn Asp Ser Ile Pro Gln Glu Asp Phe Thr Pro Glu Val Tyr Arg Val \par
225                 230                 235                 240 \par
Phe Leu Asn Asn Leu Cys Pro Arg Pro Glu Ile Asp Asn Ile Phe Ser \par
                245                 250                 255     \par
Glu Phe Gly Ala Lys Ser Lys Pro Tyr Leu Thr Val Asp Gln Met Met \par
            260                 265                 270         \par
Asp Phe Ile Asn Leu Lys Gln Arg Asp Pro Arg Leu Asn Glu Ile Leu \par
        275                 280                 285             \par
Tyr Pro Pro Leu Lys Gln Glu Gln Val Gln Val Leu Ile Glu Lys Tyr \par
    290                 295                 300                 \par
Glu Pro Asn Asn Ser Leu Ala Arg Lys Gly Gln Ile Ser Val Asp Gly \par
305                 310                 315                 320 \par
Phe Met Arg Tyr Leu Ser Gly Glu Glu Asn Gly Val Val Ser Pro Glu \par
                325                 330                 335     \par
Lys Leu Asp Leu Asn Glu Asp Met Ser Gln Pro Leu Ser His Tyr Phe \par
            340                 345                 350         \par
Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Leu Ala Gly \par
        355                 360                 365             \par
Asn Ser Ser Val Glu Met Tyr Arg Gln Val Leu Leu Ser Gly Cys Arg \par
    370                 375                 380                 \par
Cys Val Glu Leu Asp Cys Trp Lys Gly Arg Thr Ala Glu Glu Glu Pro \par
385                 390                 395                 400 \par
Val Ile Thr His Gly Phe Thr Met Thr Thr Glu Ile Ser Phe Lys Glu \par
                405                 410                 415     \par
Val Ile Glu Ala Ile Ala Glu Cys Ala Phe Lys Thr Ser Pro Phe Pro \par
            420                 425                 430         \par
Ile Leu Leu Ser Phe Glu Asn His Val Asp Ser Pro Lys Gln Gln Ala \par
        435                 440                 445             \par
Lys Met Ala Glu Tyr Cys Arg Leu Ile Phe Gly Asp Ala Leu Leu Met \par
    450                 455                 460                 \par
Glu Pro Leu Glu Lys Tyr Pro Leu Glu Ser Gly Val Pro Leu Pro Ser \par
465                 470                 475                 480 \par
Pro Met Asp Leu Met Tyr Lys Ile Leu Val Lys Asn Lys Lys Lys Ser \par
                485                 490                 495     \par
His Lys Ser Ser Glu Gly Ser Gly Lys Lys Lys Leu Ser Glu Gln Ala \par
            500                 505                 510         \par
Ser Asn Thr Tyr Ser Asp Ser Ser Ser Met Phe Glu Pro Ser Ser Pro \par
        515                 520                 525             \par
Gly Ala Gly Glu Ala Asp Thr Glu Ser Asp Asp Asp Asp Asp Asp Asp \par
    530                 535                 540                 \par
Asp Cys Lys Lys Ser Ser Met Asp Glu Gly Thr Ala Gly Ser Glu Ala \par
545                 550                 555                 560 \par
Met Ala Thr Glu Glu Met Ser Asn Leu Val Asn Tyr Ile Gln Pro Val \par
                565                 570                 575     \par
Lys Phe Glu Ser Phe Glu Ile Ser Lys Lys Arg Asn Lys Ser Phe Glu \par
            580                 585                 590         \par
Met Ser Ser Phe Val Glu Thr Lys Gly Leu Glu Gln Leu Thr Lys Ser \par
        595                 600                 605             \par
Pro Val Glu Phe Val Glu Tyr Asn Lys Met Gln Leu Ser Arg Ile Tyr \par
    610                 615                 620                 \par
Pro Lys Gly Thr Arg Val Asp Ser Ser Asn Tyr Met Pro Gln Leu Phe \par
625                 630                 635                 640 \par
Trp Asn Ala Gly Cys Gln Met Val Ala Leu Asn Phe Gln Thr Met Asp \par
                645                 650                 655     \par
Leu Ala Met Gln Ile Asn Met Gly Met Tyr Glu Tyr Asn Gly Lys Ser \par
            660                 665                 670         \par
Gly Tyr Arg Leu Lys Pro Glu Phe Met Arg Arg Pro Asp Lys His Phe \par
        675                 680                 685             \par
Asp Pro Phe Thr Glu Gly Ile Val Asp Gly Ile Val Ala Asn Thr Leu \par
    690                 695                 700                 \par
Ser Val Lys Ile Ile Ser Gly Gln Phe Leu Ser Asp Lys Lys Val Gly \par
705                 710                 715                 720 \par
Thr Tyr Val Glu Val Asp Met Phe Gly Leu Pro Val Asp Thr Arg Arg \par
                725                 730                 735     \par
Lys Ala Phe Lys Thr Lys Thr Ser Gln Gly Asn Ala Val Asn Pro Val \par
            740                 745                 750         \par
Trp Glu Glu Glu Pro Ile Val Phe Lys Lys Val Val Leu Pro Thr Leu \par
        755                 760                 765             \par
Ala Cys Leu Arg Ile Ala Val Tyr Glu Glu Gly Gly Lys Phe Ile Gly \par
    770                 775                 780                 \par
His Arg Ile Leu Pro Val Gln Ala Ile Arg Pro Gly Tyr His Tyr Ile \par
785                 790                 795                 800 \par
Cys Leu Arg Asn Glu Arg Asn Gln Pro Leu Thr Leu Pro Ala Val Phe \par
                805                 810                 815     \par
Val Tyr Ile Glu Val Lys Asp Tyr Val Pro Asp Thr Tyr Ala Asp Val \par
            820                 825                 830         \par
Ile Glu Ala Leu Ser Asn Pro Ile Arg Tyr Val Asn Leu Met Glu Gln \par
        835                 840                 845             \par
Arg Ala Lys Gln Leu Ala Ala Leu Thr Leu Glu Asp Glu Glu Glu Val \par
    850                 855                 860                 \par
Lys Lys Glu Ala Asp Pro Gly Glu Thr Pro Ser Glu Ala Pro Ser Glu \par
865                 870                 875                 880 \par
Ala Arg Thr Thr Pro Ala Glu Asn Gly Val Asn His Thr Thr Thr Leu \par
                885                 890                 895     \par
Thr Pro Lys Pro Pro Ser Gln Ala Leu His Ser Gln Pro Ala Pro Gly \par
            900                 905                 910         \par
Ser Val Lys Ala Pro Ala Lys Thr Glu Asp Leu Ile Gln Ser Val Leu \par
        915                 920                 925             \par
Thr Glu Val Glu Ala Gln Thr Ile Glu Glu Leu Lys Gln Gln Lys Ser \par
    930                 935                 940                 \par
Phe Val Lys Leu Gln Lys Lys His Tyr Lys Glu Met Lys Asp Leu Val \par
945                 950                 955                 960 \par
Lys Arg His His Lys Lys Thr Thr Asp Leu Ile Lys Glu His Thr Thr \par
                965                 970                 975     \par
Lys Tyr Asn Glu Ile Gln Asn Asp Tyr Leu Arg Arg Arg Ala Ala Leu \par
            980                 985                 990         \par
Glu Lys Ser Ala Lys Lys Asp Ser Lys Lys Lys Ser Glu Pro Ser Ser \par
        995                 1000                1005            \par
Pro Asp His Gly Ser Ser Thr Ile Glu Gln Asp Leu Ala Ala Leu Asp \par
    1010                1015                1020                \par
Ala Glu Met Thr Gln Lys Leu Ile Asp Leu Lys Asp Lys Gln Gln Gln \par
1025                1030                1035                1040\par
Gln Leu Leu Asn Leu Arg Gln Glu Gln Tyr Tyr Ser Glu Lys Tyr Gln \par
                1045                1050                1055    \par
Lys Arg Glu His Ile Lys Leu Leu Ile Gln Lys Leu Thr Asp Val Ala \par
            1060                1065                1070        \par
Glu Glu Cys Gln Asn Asn Gln Leu Lys Lys Leu Lys Glu Ile Cys Glu \par
        1075                1080                1085            \par
Lys Glu Lys Lys Glu Leu Lys Lys Lys Met Asp Lys Lys Arg Gln Glu \par
    1090                1095                1100                \par
Lys Ile Thr Glu Ala Lys Ser Lys Asp Lys Ser Gln Met Glu Glu Glu \par
1105                1110                1115                1120\par
Lys Thr Glu Met Ile Arg Ser Tyr Ile Gln Glu Val Val Gln Tyr Ile \par
                1125                1130                1135    \par
Lys Arg Leu Glu Glu Ala Gln Ser Lys Arg Gln Glu Lys Leu Val Glu \par
            1140                1145                1150        \par
Lys His Lys Glu Ile Arg Gln Gln Ile Leu Asp Glu Lys Pro Lys Leu \par
        1155                1160                1165            \par
Gln Val Glu Leu Glu Gln Glu Tyr Gln Asp Lys Phe Lys Arg Leu Pro \par
    1170                1175                1180                \par
Leu Glu Ile Leu Glu Phe Val Gln Glu Ala Met Lys Gly Lys Ile Ser \par
1185                1190                1195                1200\par
Glu Asp Ser Asn His Gly Ser Ala Pro Leu Ser Leu Ser Ser Asp Pro \par
                1205                1210                1215    \par
Gly Lys Val Asn His Lys Thr Pro Ser Ser Glu Glu Leu Gly Gly Asp \par
            1220                1225                1230        \par
Ile Pro Gly Lys Glu Phe Asp Thr Pro Leu \par
        1235                1240        \par
\par
<210> 46\par
<211> 1207\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-PLC\'ce\'b22 (SmBiT-PLCB2)\par
\par
<400> 46\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ser Leu Leu Asn Pro \par
            20                  25                  30          \par
Val Leu Leu Pro Pro Lys Val Lys Ala Tyr Leu Ser Gln Gly Glu Arg \par
        35                  40                  45              \par
Phe Ile Lys Trp Asp Asp Glu Thr Thr Val Ala Ser Pro Val Ile Leu \par
    50                  55                  60                  \par
Arg Val Asp Pro Lys Gly Tyr Tyr Leu Tyr Trp Thr Tyr Gln Ser Lys \par
65                  70                  75                  80  \par
Glu Met Glu Phe Leu Asp Ile Thr Ser Ile Arg Asp Thr Arg Phe Gly \par
                85                  90                  95      \par
Lys Phe Ala Lys Met Pro Lys Ser Gln Lys Leu Arg Asp Val Phe Asn \par
            100                 105                 110         \par
Met Asp Phe Pro Asp Asn Ser Phe Leu Leu Lys Thr Leu Thr Val Val \par
        115                 120                 125             \par
Ser Gly Pro Asp Met Val Asp Leu Thr Phe His Asn Phe Val Ser Tyr \par
    130                 135                 140                 \par
Lys Glu Asn Val Gly Lys Ala Trp Ala Glu Asp Val Leu Ala Leu Val \par
145                 150                 155                 160 \par
Lys His Pro Leu Thr Ala Asn Ala Ser Arg Ser Thr Phe Leu Asp Lys \par
                165                 170                 175     \par
Ile Leu Val Lys Leu Lys Met Gln Leu Asn Ser Glu Gly Lys Ile Pro \par
            180                 185                 190         \par
Val Lys Asn Phe Phe Gln Met Phe Pro Ala Asp Arg Lys Arg Val Glu \par
        195                 200                 205             \par
Ala Ala Leu Ser Ala Cys His Leu Pro Lys Gly Lys Asn Asp Ala Ile \par
    210                 215                 220                 \par
Asn Pro Glu Asp Phe Pro Glu Pro Val Tyr Lys Ser Phe Leu Met Ser \par
225                 230                 235                 240 \par
Leu Cys Pro Arg Pro Glu Ile Asp Glu Ile Phe Thr Ser Tyr His Ala \par
                245                 250                 255     \par
Lys Ala Lys Pro Tyr Met Thr Lys Glu His Leu Thr Lys Phe Ile Asn \par
            260                 265                 270         \par
Gln Lys Gln Arg Asp Ser Arg Leu Asn Ser Leu Leu Phe Pro Pro Ala \par
        275                 280                 285             \par
Arg Pro Asp Gln Val Gln Gly Leu Ile Asp Lys Tyr Glu Pro Ser Gly \par
    290                 295                 300                 \par
Ile Asn Ala Gln Arg Gly Gln Leu Ser Pro Glu Gly Met Val Trp Phe \par
305                 310                 315                 320 \par
Leu Cys Gly Pro Glu Asn Ser Val Leu Ala Gln Asp Lys Leu Leu Leu \par
                325                 330                 335     \par
His His Asp Met Thr Gln Pro Leu Asn His Tyr Phe Ile Asn Ser Ser \par
            340                 345                 350         \par
His Asn Thr Tyr Leu Thr Ala Gly Gln Phe Ser Gly Leu Ser Ser Ala \par
        355                 360                 365             \par
Glu Met Tyr Arg Gln Val Leu Leu Ser Gly Cys Arg Cys Val Glu Leu \par
    370                 375                 380                 \par
Asp Cys Trp Lys Gly Lys Pro Pro Asp Glu Glu Pro Ile Ile Thr His \par
385                 390                 395                 400 \par
Gly Phe Thr Met Thr Thr Asp Ile Phe Phe Lys Glu Ala Ile Glu Ala \par
                405                 410                 415     \par
Ile Ala Glu Ser Ala Phe Lys Thr Ser Pro Tyr Pro Ile Ile Leu Ser \par
            420                 425                 430         \par
Phe Glu Asn His Val Asp Ser Pro Arg Gln Gln Ala Lys Met Ala Glu \par
        435                 440                 445             \par
Tyr Cys Arg Thr Ile Phe Gly Asp Met Leu Leu Thr Glu Pro Leu Glu \par
    450                 455                 460                 \par
Lys Phe Pro Leu Lys Pro Gly Val Pro Leu Pro Ser Pro Glu Asp Leu \par
465                 470                 475                 480 \par
Arg Gly Lys Ile Leu Ile Lys Asn Lys Lys Asn Gln Phe Ser Gly Pro \par
                485                 490                 495     \par
Thr Ser Ser Ser Lys Asp Thr Gly Gly Glu Ala Glu Gly Ser Ser Pro \par
            500                 505                 510         \par
Pro Ser Ala Pro Ala Val Trp Ala Gly Glu Glu Gly Thr Glu Leu Glu \par
        515                 520                 525             \par
Glu Glu Glu Val Glu Glu Glu Glu Glu Glu Glu Ser Gly Asn Leu Asp \par
    530                 535                 540                 \par
Glu Glu Glu Ile Lys Lys Met Gln Ser Asp Glu Gly Thr Ala Gly Leu \par
545                 550                 555                 560 \par
Glu Val Thr Ala Tyr Glu Glu Met Ser Ser Leu Val Asn Tyr Ile Gln \par
                565                 570                 575     \par
Pro Thr Lys Phe Val Ser Phe Glu Phe Ser Ala Gln Lys Asn Arg Ser \par
            580                 585                 590         \par
Tyr Val Ile Ser Ser Phe Thr Glu Leu Lys Ala Tyr Asp Leu Leu Ser \par
        595                 600                 605             \par
Lys Ala Ser Val Gln Phe Val Asp Tyr Asn Lys Arg Gln Met Ser Arg \par
    610                 615                 620                 \par
Ile Tyr Pro Lys Gly Thr Arg Met Asp Ser Ser Asn Tyr Met Pro Gln \par
625                 630                 635                 640 \par
Met Phe Trp Asn Ala Gly Cys Gln Met Val Ala Leu Asn Phe Gln Thr \par
                645                 650                 655     \par
Met Asp Leu Pro Met Gln Gln Asn Met Ala Val Phe Glu Phe Asn Gly \par
            660                 665                 670         \par
Gln Ser Gly Tyr Leu Leu Lys His Glu Phe Met Arg Arg Pro Asp Lys \par
        675                 680                 685             \par
Gln Phe Asn Pro Phe Ser Val Asp Arg Ile Asp Val Val Val Ala Thr \par
    690                 695                 700                 \par
Thr Leu Ser Ile Thr Val Ile Ser Gly Gln Phe Leu Ser Glu Arg Ser \par
705                 710                 715                 720 \par
Val Arg Thr Tyr Val Glu Val Glu Leu Phe Gly Leu Pro Gly Asp Pro \par
                725                 730                 735     \par
Lys Arg Arg Tyr Arg Thr Lys Leu Ser Pro Ser Thr Asn Ser Ile Asn \par
            740                 745                 750         \par
Pro Val Trp Lys Glu Glu Pro Phe Val Phe Glu Lys Ile Leu Met Pro \par
        755                 760                 765             \par
Glu Leu Ala Ser Leu Arg Val Ala Val Met Glu Glu Gly Asn Lys Phe \par
    770                 775                 780                 \par
Leu Gly His Arg Ile Ile Pro Ile Asn Ala Leu Asn Ser Gly Tyr His \par
785                 790                 795                 800 \par
His Leu Cys Leu His Ser Glu Ser Asn Met Pro Leu Thr Met Pro Ala \par
                805                 810                 815     \par
Leu Phe Ile Phe Leu Glu Met Lys Asp Tyr Ile Pro Gly Ala Trp Ala \par
            820                 825                 830         \par
Asp Leu Thr Val Ala Leu Ala Asn Pro Ile Lys Phe Phe Ser Ala His \par
        835                 840                 845             \par
Asp Thr Lys Ser Val Lys Leu Lys Glu Ala Met Gly Gly Leu Pro Glu \par
    850                 855                 860                 \par
Lys Pro Phe Pro Leu Ala Ser Pro Val Ala Ser Gln Val Asn Gly Ala \par
865                 870                 875                 880 \par
Leu Ala Pro Thr Ser Asn Gly Ser Pro Ala Ala Arg Ala Gly Ala Arg \par
                885                 890                 895     \par
Glu Glu Ala Met Lys Glu Ala Ala Glu Pro Arg Thr Ala Ser Leu Glu \par
            900                 905                 910         \par
Glu Leu Arg Glu Leu Lys Gly Val Val Lys Leu Gln Arg Arg His Glu \par
        915                 920                 925             \par
Lys Glu Leu Arg Glu Leu Glu Arg Arg Gly Ala Arg Arg Trp Glu Glu \par
    930                 935                 940                 \par
Leu Leu Gln Arg Gly Ala Ala Gln Leu Ala Glu Leu Gly Pro Pro Gly \par
945                 950                 955                 960 \par
Val Gly Gly Val Gly Ala Cys Lys Leu Gly Pro Gly Lys Gly Ser Arg \par
                965                 970                 975     \par
Lys Lys Arg Ser Leu Pro Arg Glu Glu Ser Ala Gly Ala Ala Pro Gly \par
            980                 985                 990         \par
Glu Gly Pro Glu Gly Val Asp Gly Arg Val Arg Glu Leu Lys Asp Arg \par
        995                 1000                1005            \par
Leu Glu Leu Glu Leu Leu Arg Gln Gly Glu Glu Gln Tyr Glu Cys Val \par
    1010                1015                1020                \par
Leu Lys Arg Lys Glu Gln His Val Ala Glu Gln Ile Ser Lys Met Met \par
1025                1030                1035                1040\par
Glu Leu Ala Arg Glu Lys Gln Ala Ala Glu Leu Lys Ala Leu Lys Glu \par
                1045                1050                1055    \par
Thr Ser Glu Asn Asp Thr Lys Glu Met Lys Lys Lys Leu Glu Thr Lys \par
            1060                1065                1070        \par
Arg Leu Glu Arg Ile Gln Gly Met Thr Lys Val Thr Thr Asp Lys Met \par
        1075                1080                1085            \par
Ala Gln Glu Arg Leu Lys Arg Glu Ile Asn Asn Ser His Ile Gln Glu \par
    1090                1095                1100                \par
Val Val Gln Val Ile Lys Gln Met Thr Glu Asn Leu Glu Arg His Gln \par
1105                1110                1115                1120\par
Glu Lys Leu Glu Glu Lys Gln Ala Ala Cys Leu Glu Gln Ile Arg Glu \par
                1125                1130                1135    \par
Met Glu Lys Gln Phe Gln Lys Glu Ala Leu Ala Glu Tyr Glu Ala Arg \par
            1140                1145                1150        \par
Met Lys Gly Leu Glu Ala Glu Val Lys Glu Ser Val Arg Ala Cys Leu \par
        1155                1160                1165            \par
Arg Thr Cys Phe Pro Ser Glu Ala Lys Asp Lys Pro Glu Arg Ala Cys \par
    1170                1175                1180                \par
Glu Cys Pro Pro Glu Leu Cys Glu Gln Asp Pro Leu Ile Ala Lys Ala \par
1185                1190                1195                1200\par
Asp Ala Gln Glu Ser Arg Leu \par
                1205        \par
\par
<210> 47\par
<211> 1260\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-PLC\'ce\'b23 (SmBiT-PLCB3)\par
\par
<400> 47\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Gly Ala Gln Pro \par
            20                  25                  30          \par
Gly Val His Ala Leu Gln Leu Glu Pro Pro Thr Val Val Glu Thr Leu \par
        35                  40                  45              \par
Arg Arg Gly Ser Lys Phe Ile Lys Trp Asp Glu Glu Thr Ser Ser Arg \par
    50                  55                  60                  \par
Asn Leu Val Thr Leu Arg Val Asp Pro Asn Gly Phe Phe Leu Tyr Trp \par
65                  70                  75                  80  \par
Thr Gly Pro Asn Met Glu Val Asp Thr Leu Asp Ile Ser Ser Ile Arg \par
                85                  90                  95      \par
Asp Thr Arg Thr Gly Arg Tyr Ala Arg Leu Pro Lys Asp Pro Lys Ile \par
            100                 105                 110         \par
Arg Glu Val Leu Gly Phe Gly Gly Pro Asp Ala Arg Leu Glu Glu Lys \par
        115                 120                 125             \par
Leu Met Thr Val Val Ser Gly Pro Asp Pro Val Asn Thr Val Phe Leu \par
    130                 135                 140                 \par
Asn Phe Met Ala Val Gln Asp Asp Thr Ala Lys Val Trp Ser Glu Glu \par
145                 150                 155                 160 \par
Leu Phe Lys Leu Ala Met Asn Ile Leu Ala Gln Asn Ala Ser Arg Asn \par
                165                 170                 175     \par
Thr Phe Leu Arg Lys Ala Tyr Thr Lys Leu Lys Leu Gln Val Asn Gln \par
            180                 185                 190         \par
Asp Gly Arg Ile Pro Val Lys Asn Ile Leu Lys Met Phe Ser Ala Asp \par
        195                 200                 205             \par
Lys Lys Arg Val Glu Thr Ala Leu Glu Ser Cys Gly Leu Lys Phe Asn \par
    210                 215                 220                 \par
Arg Ser Glu Ser Ile Arg Pro Asp Glu Phe Ser Leu Glu Ile Phe Glu \par
225                 230                 235                 240 \par
Arg Phe Leu Asn Lys Leu Cys Leu Arg Pro Asp Ile Asp Lys Ile Leu \par
                245                 250                 255     \par
Leu Glu Ile Gly Ala Lys Gly Lys Pro Tyr Leu Thr Leu Glu Gln Leu \par
            260                 265                 270         \par
Met Asp Phe Ile Asn Gln Lys Gln Arg Asp Pro Arg Leu Asn Glu Val \par
        275                 280                 285             \par
Leu Tyr Pro Pro Leu Arg Pro Ser Gln Ala Arg Leu Leu Ile Glu Lys \par
    290                 295                 300                 \par
Tyr Glu Pro Asn Gln Gln Phe Leu Glu Arg Asp Gln Met Ser Met Glu \par
305                 310                 315                 320 \par
Gly Phe Ser Arg Tyr Leu Gly Gly Glu Glu Asn Gly Ile Leu Pro Leu \par
                325                 330                 335     \par
Glu Ala Leu Asp Leu Ser Thr Asp Met Thr Gln Pro Leu Ser Ala Tyr \par
            340                 345                 350         \par
Phe Ile Asn Ser Ser His Asn Thr Tyr Leu Thr Ala Gly Gln Leu Ala \par
        355                 360                 365             \par
Gly Thr Ser Ser Val Glu Met Tyr Arg Gln Ala Leu Leu Trp Gly Cys \par
    370                 375                 380                 \par
Arg Cys Val Glu Leu Asp Val Trp Lys Gly Arg Pro Pro Glu Glu Glu \par
385                 390                 395                 400 \par
Pro Phe Ile Thr His Gly Phe Thr Met Thr Thr Glu Val Pro Leu Arg \par
                405                 410                 415     \par
Asp Val Leu Glu Ala Ile Ala Glu Thr Ala Phe Lys Thr Ser Pro Tyr \par
            420                 425                 430         \par
Pro Val Ile Leu Ser Phe Glu Asn His Val Asp Ser Ala Lys Gln Gln \par
        435                 440                 445             \par
Ala Lys Met Ala Glu Tyr Cys Arg Ser Ile Phe Gly Asp Ala Leu Leu \par
    450                 455                 460                 \par
Ile Glu Pro Leu Asp Lys Tyr Pro Leu Ala Pro Gly Val Pro Leu Pro \par
465                 470                 475                 480 \par
Ser Pro Gln Asp Leu Met Gly Arg Ile Leu Val Lys Asn Lys Lys Arg \par
                485                 490                 495     \par
His Arg Pro Ser Ala Gly Gly Pro Asp Ser Ala Gly Arg Lys Arg Pro \par
            500                 505                 510         \par
Leu Glu Gln Ser Asn Ser Ala Leu Ser Glu Ser Ser Ala Ala Thr Glu \par
        515                 520                 525             \par
Pro Ser Ser Pro Gln Leu Gly Ser Pro Ser Ser Asp Ser Cys Pro Gly \par
    530                 535                 540                 \par
Leu Ser Asn Gly Glu Glu Val Gly Leu Glu Lys Pro Ser Leu Glu Pro \par
545                 550                 555                 560 \par
Gln Lys Ser Leu Gly Asp Glu Gly Leu Asn Arg Gly Pro Tyr Val Leu \par
                565                 570                 575     \par
Gly Pro Ala Asp Arg Glu Asp Glu Glu Glu Asp Glu Glu Glu Glu Glu \par
            580                 585                 590         \par
Gln Thr Asp Pro Lys Lys Pro Thr Thr Asp Glu Gly Thr Ala Ser Ser \par
        595                 600                 605             \par
Glu Val Asn Ala Thr Glu Glu Met Ser Thr Leu Val Asn Tyr Ile Glu \par
    610                 615                 620                 \par
Pro Val Lys Phe Lys Ser Phe Glu Ala Ala Arg Lys Arg Asn Lys Cys \par
625                 630                 635                 640 \par
Phe Glu Met Ser Ser Phe Val Glu Thr Lys Ala Met Glu Gln Leu Thr \par
                645                 650                 655     \par
Lys Ser Pro Met Glu Phe Val Glu Tyr Asn Lys Gln Gln Leu Ser Arg \par
            660                 665                 670         \par
Ile Tyr Pro Lys Gly Thr Arg Val Asp Ser Ser Asn Tyr Met Pro Gln \par
        675                 680                 685             \par
Leu Phe Trp Asn Val Gly Cys Gln Leu Val Ala Leu Asn Phe Gln Thr \par
    690                 695                 700                 \par
Leu Asp Val Ala Met Gln Leu Asn Ala Gly Val Phe Glu Tyr Asn Gly \par
705                 710                 715                 720 \par
Arg Ser Gly Tyr Leu Leu Lys Pro Glu Phe Met Arg Arg Pro Asp Lys \par
                725                 730                 735     \par
Ser Phe Asp Pro Phe Thr Glu Val Ile Val Asp Gly Ile Val Ala Asn \par
            740                 745                 750         \par
Ala Leu Arg Val Lys Val Ile Ser Gly Gln Phe Leu Ser Asp Arg Lys \par
        755                 760                 765             \par
Val Gly Ile Tyr Val Glu Val Asp Met Phe Gly Leu Pro Val Asp Thr \par
    770                 775                 780                 \par
Arg Arg Lys Tyr Arg Thr Arg Thr Ser Gln Gly Asn Ser Phe Asn Pro \par
785                 790                 795                 800 \par
Val Trp Asp Glu Glu Pro Phe Asp Phe Pro Lys Val Val Leu Pro Thr \par
                805                 810                 815     \par
Leu Ala Ser Leu Arg Ile Ala Ala Phe Glu Glu Gly Gly Lys Phe Val \par
            820                 825                 830         \par
Gly His Arg Ile Leu Pro Val Ser Ala Ile Arg Ser Gly Tyr His Tyr \par
        835                 840                 845             \par
Val Cys Leu Arg Asn Glu Ala Asn Gln Pro Leu Cys Leu Pro Ala Leu \par
    850                 855                 860                 \par
Leu Ile Tyr Thr Glu Ala Ser Asp Tyr Ile Pro Asp Asp His Gln Asp \par
865                 870                 875                 880 \par
Tyr Ala Glu Ala Leu Ile Asn Pro Ile Lys His Val Ser Leu Met Asp \par
                885                 890                 895     \par
Gln Arg Ala Arg Gln Leu Ala Ala Leu Ile Gly Glu Ser Glu Ala Gln \par
            900                 905                 910         \par
Ala Gly Gln Glu Thr Cys Gln Asp Thr Gln Ser Gln Gln Leu Gly Ser \par
        915                 920                 925             \par
Gln Pro Ser Ser Asn Pro Thr Pro Ser Pro Leu Asp Ala Ser Pro Arg \par
    930                 935                 940                 \par
Arg Pro Pro Gly Pro Thr Thr Ser Pro Ala Ser Thr Ser Leu Ser Ser \par
945                 950                 955                 960 \par
Pro Gly Gln Arg Asp Asp Leu Ile Ala Ser Ile Leu Ser Glu Val Ala \par
                965                 970                 975     \par
Pro Thr Pro Leu Asp Glu Leu Arg Gly His Lys Ala Leu Val Lys Leu \par
            980                 985                 990         \par
Arg Ser Arg Gln Glu Arg Asp Leu Arg Glu Leu Arg Lys Lys His Gln \par
        995                 1000                1005            \par
Arg Lys Ala Val Thr Leu Thr Arg Arg Leu Leu Asp Gly Leu Ala Gln \par
    1010                1015                1020                \par
Ala Gln Ala Glu Gly Arg Cys Arg Leu Arg Pro Gly Ala Leu Gly Gly \par
1025                1030                1035                1040\par
Ala Ala Asp Val Glu Asp Thr Lys Glu Gly Glu Asp Glu Ala Lys Arg \par
                1045                1050                1055    \par
Tyr Gln Glu Phe Gln Asn Arg Gln Val Gln Ser Leu Leu Glu Leu Arg \par
            1060                1065                1070        \par
Glu Ala Gln Val Asp Ala Glu Ala Gln Arg Arg Leu Glu His Leu Arg \par
        1075                1080                1085            \par
Gln Ala Leu Gln Arg Leu Arg Glu Val Val Leu Asp Ala Asn Thr Thr \par
    1090                1095                1100                \par
Gln Phe Lys Arg Leu Lys Glu Met Asn Glu Arg Glu Lys Lys Glu Leu \par
1105                1110                1115                1120\par
Gln Lys Ile Leu Asp Arg Lys Arg His Asn Ser Ile Ser Glu Ala Lys \par
                1125                1130                1135    \par
Met Arg Asp Lys His Lys Lys Glu Ala Glu Leu Thr Glu Ile Asn Arg \par
            1140                1145                1150        \par
Arg His Ile Thr Glu Ser Val Asn Ser Ile Arg Arg Leu Glu Glu Ala \par
        1155                1160                1165            \par
Gln Lys Gln Arg His Asp Arg Leu Val Ala Gly Gln Gln Gln Val Leu \par
    1170                1175                1180                \par
Gln Gln Leu Ala Glu Glu Glu Pro Lys Leu Leu Ala Gln Leu Ala Gln \par
1185                1190                1195                1200\par
Glu Cys Gln Glu Gln Arg Ala Arg Leu Pro Gln Glu Ile Arg Arg Ser \par
                1205                1210                1215    \par
Leu Leu Gly Glu Met Pro Glu Gly Leu Gly Asp Gly Pro Leu Val Ala \par
            1220                1225                1230        \par
Cys Ala Ser Asn Gly His Ala Pro Gly Ser Ser Gly His Leu Ser Gly \par
        1235                1240                1245            \par
Ala Asp Ser Glu Ser Gln Glu Glu Asn Thr Gln Leu \par
    1250                1255                1260\par
\par
<210> 48\par
<211> 1220\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-PLC\'ce\'b24 (SmBiT-PLCB4)\par
\par
<400> 48\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Ala Lys Pro Tyr Glu \par
            20                  25                  30          \par
Phe Asn Trp Gln Lys Glu Val Pro Ser Phe Leu Gln Glu Gly Ala Val \par
        35                  40                  45              \par
Phe Asp Arg Tyr Glu Glu Glu Ser Phe Val Phe Glu Pro Asn Cys Leu \par
    50                  55                  60                  \par
Phe Lys Val Asp Glu Phe Gly Phe Phe Leu Thr Trp Arg Ser Glu Gly \par
65                  70                  75                  80  \par
Lys Glu Gly Gln Val Leu Glu Cys Ser Leu Ile Asn Ser Ile Arg Ser \par
                85                  90                  95      \par
Gly Ala Ile Pro Lys Asp Pro Lys Ile Leu Ala Ala Leu Glu Ala Val \par
            100                 105                 110         \par
Gly Lys Ser Glu Asn Asp Leu Glu Gly Arg Ile Val Cys Val Cys Ser \par
        115                 120                 125             \par
Gly Thr Asp Leu Val Asn Ile Ser Phe Thr Tyr Met Val Ala Glu Asn \par
    130                 135                 140                 \par
Pro Glu Val Thr Lys Gln Trp Val Glu Gly Leu Arg Ser Ile Ile His \par
145                 150                 155                 160 \par
Asn Phe Arg Ala Asn Asn Val Ser Pro Met Thr Cys Leu Lys Lys His \par
                165                 170                 175     \par
Trp Met Lys Leu Ala Phe Met Thr Asn Thr Asn Gly Lys Ile Pro Val \par
            180                 185                 190         \par
Arg Ser Ile Thr Arg Thr Phe Ala Ser Gly Lys Thr Glu Lys Val Ile \par
        195                 200                 205             \par
Phe Gln Ala Leu Lys Glu Leu Gly Leu Pro Ser Gly Lys Asn Asp Glu \par
    210                 215                 220                 \par
Ile Glu Pro Thr Ala Phe Ser Tyr Glu Lys Phe Tyr Glu Leu Thr Gln \par
225                 230                 235                 240 \par
Lys Ile Cys Pro Arg Thr Asp Ile Glu Asp Leu Phe Lys Lys Ile Asn \par
                245                 250                 255     \par
Gly Asp Lys Thr Asp Tyr Leu Thr Val Asp Gln Leu Val Ser Phe Leu \par
            260                 265                 270         \par
Asn Glu His Gln Arg Asp Pro Arg Leu Asn Glu Ile Leu Phe Pro Phe \par
        275                 280                 285             \par
Tyr Asp Ala Lys Arg Ala Met Gln Ile Ile Glu Met Tyr Glu Pro Asp \par
    290                 295                 300                 \par
Glu Asp Leu Lys Lys Lys Gly Leu Ile Ser Ser Asp Gly Phe Cys Arg \par
305                 310                 315                 320 \par
Tyr Leu Met Ser Asp Glu Asn Ala Pro Val Phe Leu Asp Arg Leu Glu \par
                325                 330                 335     \par
Leu Tyr Gln Glu Met Asp His Pro Leu Ala His Tyr Phe Ile Ser Ser \par
            340                 345                 350         \par
Ser His Asn Thr Tyr Leu Thr Gly Arg Gln Phe Gly Gly Lys Ser Ser \par
        355                 360                 365             \par
Val Glu Met Tyr Arg Gln Val Leu Leu Ala Gly Cys Arg Cys Val Glu \par
    370                 375                 380                 \par
Leu Asp Cys Trp Asp Gly Lys Gly Glu Asp Gln Glu Pro Ile Ile Thr \par
385                 390                 395                 400 \par
His Gly Lys Ala Met Cys Thr Asp Ile Leu Phe Lys Asp Val Ile Gln \par
                405                 410                 415     \par
Ala Ile Lys Glu Thr Ala Phe Val Thr Ser Glu Tyr Pro Val Ile Leu \par
            420                 425                 430         \par
Ser Phe Glu Asn His Cys Ser Lys Tyr Gln Gln Tyr Lys Met Ser Lys \par
        435                 440                 445             \par
Tyr Cys Glu Asp Leu Phe Gly Asp Leu Leu Leu Lys Gln Ala Leu Glu \par
    450                 455                 460                 \par
Ser His Pro Leu Glu Pro Gly Arg Ala Leu Pro Ser Pro Asn Asp Leu \par
465                 470                 475                 480 \par
Lys Arg Lys Ile Leu Ile Lys Asn Lys Arg Leu Lys Pro Glu Val Glu \par
                485                 490                 495     \par
Lys Lys Gln Leu Glu Ala Leu Arg Ser Met Met Glu Ala Gly Glu Ser \par
            500                 505                 510         \par
Ala Ser Pro Ala Asn Ile Leu Glu Asp Asp Asn Glu Glu Glu Ile Glu \par
        515                 520                 525             \par
Ser Ala Asp Gln Glu Glu Glu Ala His Pro Glu Phe Lys Phe Gly Asn \par
    530                 535                 540                 \par
Glu Leu Ser Ala Asp Asp Leu Gly His Lys Glu Ala Val Ala Asn Ser \par
545                 550                 555                 560 \par
Val Lys Lys Gly Leu Val Thr Val Glu Asp Glu Gln Ala Trp Met Ala \par
                565                 570                 575     \par
Ser Tyr Lys Tyr Val Gly Ala Thr Thr Asn Ile His Pro Tyr Leu Ser \par
            580                 585                 590         \par
Thr Met Ile Asn Tyr Ala Gln Pro Val Lys Phe Gln Gly Phe His Val \par
        595                 600                 605             \par
Ala Glu Glu Arg Asn Ile His Tyr Asn Met Ser Ser Phe Asn Glu Ser \par
    610                 615                 620                 \par
Val Gly Leu Gly Tyr Leu Lys Thr His Ala Ile Glu Phe Val Asn Tyr \par
625                 630                 635                 640 \par
Asn Lys Arg Gln Met Ser Arg Ile Tyr Pro Lys Gly Gly Arg Val Asp \par
                645                 650                 655     \par
Ser Ser Asn Tyr Met Pro Gln Ile Phe Trp Asn Ala Gly Cys Gln Met \par
            660                 665                 670         \par
Val Ser Leu Asn Tyr Gln Thr Pro Asp Leu Ala Met Gln Leu Asn Gln \par
        675                 680                 685             \par
Gly Lys Phe Glu Tyr Asn Gly Ser Cys Gly Tyr Leu Leu Lys Pro Asp \par
    690                 695                 700                 \par
Phe Met Arg Arg Pro Asp Arg Thr Phe Asp Pro Phe Ser Glu Thr Pro \par
705                 710                 715                 720 \par
Val Asp Gly Val Ile Ala Ala Thr Cys Ser Val Gln Val Ile Ser Gly \par
                725                 730                 735     \par
Gln Phe Leu Ser Asp Lys Lys Ile Gly Thr Tyr Val Glu Val Asp Met \par
            740                 745                 750         \par
Tyr Gly Leu Pro Thr Asp Thr Ile Arg Lys Glu Phe Arg Thr Arg Met \par
        755                 760                 765             \par
Val Met Asn Asn Gly Leu Asn Pro Val Tyr Asn Glu Glu Ser Phe Val \par
    770                 775                 780                 \par
Phe Arg Lys Val Ile Leu Pro Asp Leu Ala Val Leu Arg Ile Ala Val \par
785                 790                 795                 800 \par
Tyr Asp Asp Asn Asn Lys Leu Ile Gly Gln Arg Ile Leu Pro Leu Asp \par
                805                 810                 815     \par
Gly Leu Gln Ala Gly Tyr Arg His Ile Ser Leu Arg Asn Glu Gly Asn \par
            820                 825                 830         \par
Lys Pro Leu Ser Leu Pro Thr Ile Phe Cys Asn Ile Val Leu Lys Thr \par
        835                 840                 845             \par
Tyr Val Pro Asp Gly Phe Gly Asp Ile Val Asp Ala Leu Ser Asp Pro \par
    850                 855                 860                 \par
Lys Lys Phe Leu Ser Ile Thr Glu Lys Arg Ala Asp Gln Met Arg Ala \par
865                 870                 875                 880 \par
Met Gly Ile Glu Thr Ser Asp Ile Ala Asp Val Pro Ser Asp Thr Ser \par
                885                 890                 895     \par
Lys Asn Asp Lys Lys Gly Lys Ala Asn Thr Ala Lys Ala Asn Val Thr \par
            900                 905                 910         \par
Pro Gln Ser Ser Ser Glu Leu Arg Pro Thr Thr Thr Ala Ala Leu Ala \par
        915                 920                 925             \par
Ser Gly Val Glu Ala Lys Lys Gly Ile Glu Leu Ile Pro Gln Val Arg \par
    930                 935                 940                 \par
Ile Glu Asp Leu Lys Gln Met Lys Ala Tyr Leu Lys His Leu Lys Lys \par
945                 950                 955                 960 \par
Gln Gln Lys Glu Leu Asn Ser Leu Lys Lys Lys His Ala Lys Glu His \par
                965                 970                 975     \par
Ser Thr Met Gln Lys Leu His Cys Thr Gln Val Asp Lys Ile Val Ala \par
            980                 985                 990         \par
Gln Tyr Asp Lys Glu Lys Ser Thr His Glu Lys Ile Leu Glu Lys Ala \par
        995                 1000                1005            \par
Met Lys Lys Lys Gly Gly Ser Asn Cys Leu Glu Met Lys Lys Glu Thr \par
    1010                1015                1020                \par
Glu Ile Lys Ile Gln Thr Leu Thr Ser Asp His Lys Ser Lys Val Lys \par
1025                1030                1035                1040\par
Glu Ile Val Ala Gln His Thr Lys Glu Trp Ser Glu Met Ile Asn Thr \par
                1045                1050                1055    \par
His Ser Ala Glu Glu Gln Glu Ile Arg Asp Leu His Leu Ser Gln Gln \par
            1060                1065                1070        \par
Cys Glu Leu Leu Lys Lys Leu Leu Ile Asn Ala His Glu Gln Gln Thr \par
        1075                1080                1085            \par
Gln Gln Leu Lys Leu Ser His Asp Arg Glu Ser Lys Glu Met Arg Ala \par
    1090                1095                1100                \par
His Gln Ala Lys Ile Ser Met Glu Asn Ser Lys Ala Ile Ser Gln Asp \par
1105                1110                1115                1120\par
Lys Ser Ile Lys Asn Lys Ala Glu Arg Glu Arg Arg Val Arg Glu Leu \par
                1125                1130                1135    \par
Asn Ser Ser Asn Thr Lys Lys Phe Leu Glu Glu Arg Lys Arg Leu Ala \par
            1140                1145                1150        \par
Met Lys Gln Ser Lys Glu Met Asp Gln Leu Lys Lys Val Gln Leu Glu \par
        1155                1160                1165            \par
His Leu Glu Phe Leu Glu Lys Gln Asn Glu Gln Leu Leu Lys Ser Cys \par
    1170                1175                1180                \par
His Ala Val Ser Gln Thr Gln Gly Glu Gly Asp Ala Ala Asp Gly Glu \par
1185                1190                1195                1200\par
Ile Gly Ser Arg Asp Gly Pro Gln Thr Ser Asn Ser Ser Met Lys Leu \par
                1205                1210                1215    \par
Gln Asn Ala Asn \par
            1220\par
\par
<210> 49\par
<211> 158\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> LgBiT luciferase fragment\par
\par
<400> 49\par
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala Ala \par
1               5                   10                  15      \par
Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Leu \par
            20                  25                  30          \par
Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg Ser \par
        35                  40                  45              \par
Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu \par
    50                  55                  60                  \par
Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys Val \par
65                  70                  75                  80  \par
Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr Gly \par
                85                  90                  95      \par
Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe Gly \par
            100                 105                 110         \par
Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val \par
        115                 120                 125             \par
Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile \par
    130                 135                 140                 \par
Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser \par
145                 150                 155             \par
\par
<210> 50\par
<211> 12\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<400> 50\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu \par
1               5                   10          \par
\par
<210> 51\par
<211> 15\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<400> 51\par
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly \par
1               5                   10                  15  \par
\par
<210> 52\par
<211> 8\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<400> 52\par
Asp Tyr Lys Asp Asp Asp Asp Lys \par
1               5               \par
\par
<210> 53\par
<211> 14\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Flag epitope DREADD without linker GS / GSG\par
\par
<400> 53\par
Arg Thr Ala Lys Gln Asn Pro Leu Thr Glu Lys Ser Gly Val \par
1               5                   10                  \par
\par
<210> 54\par
<211> 9\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<400> 54\par
Gln Ser Met Gly Leu Ser Ala Ala Gln \par
1               5                   \par
\par
<210> 55\par
<211> 367\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Lg-RhoA (LgBiT-RHOA)\par
\par
<400> 55\par
Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala \par
1               5                   10                  15      \par
Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu \par
            20                  25                  30          \par
Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg \par
        35                  40                  45              \par
Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr \par
    50                  55                  60                  \par
Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys \par
65                  70                  75                  80  \par
Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr \par
                85                  90                  95      \par
Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe \par
            100                 105                 110         \par
Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr \par
        115                 120                 125             \par
Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu \par
    130                 135                 140                 \par
Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly \par
145                 150                 155                 160 \par
Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Thr Ala \par
                165                 170                 175     \par
Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys Gly Lys \par
            180                 185                 190         \par
Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu Val Tyr \par
        195                 200                 205             \par
Val Pro Thr Val Phe Glu Asn Tyr Val Ala Asp Ile Glu Val Asp Gly \par
    210                 215                 220                 \par
Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu Asp Tyr \par
225                 230                 235                 240 \par
Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile Leu Met \par
                245                 250                 255     \par
Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro Glu Lys \par
            260                 265                 270         \par
Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile Ile Leu \par
        275                 280                 285             \par
Val Gly Asn Lys Lys Asp Leu Arg Asn Asp Glu His Thr Arg Arg Glu \par
    290                 295                 300                 \par
Leu Ala Lys Met Lys Gln Glu Pro Val Lys Pro Glu Glu Gly Arg Asp \par
305                 310                 315                 320 \par
Met Ala Asn Arg Ile Gly Ala Phe Gly Tyr Met Glu Cys Ser Ala Lys \par
                325                 330                 335     \par
Thr Lys Asp Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg Ala Ala \par
            340                 345                 350         \par
Leu Gln Ala Arg Arg Gly Lys Lys Lys Ser Gly Cys Leu Val Leu \par
        355                 360                 365         \par
\par
<210> 56\par
<211> 127\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Sm-PKN1 (SmBiT-PKN1-GBD)\par
\par
<400> 56\par
Met Val Thr Gly Tyr Arg Leu Phe Glu Glu Ile Leu Gly Gly Ser Gly \par
1               5                   10                  15      \par
Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Glu Ser Glu Pro Arg \par
            20                  25                  30          \par
Ser Trp Ser Leu Leu Glu Gln Leu Gly Leu Ala Gly Ala Asp Leu Ala \par
        35                  40                  45              \par
Ala Pro Gly Val Gln Gln Gln Leu Glu Leu Glu Arg Glu Arg Leu Arg \par
    50                  55                  60                  \par
Arg Glu Ile Arg Lys Glu Leu Lys Leu Lys Glu Gly Ala Glu Asn Leu \par
65                  70                  75                  80  \par
Arg Arg Ala Thr Thr Asp Leu Gly Arg Ser Leu Gly Pro Val Glu Leu \par
                85                  90                  95      \par
Leu Leu Arg Gly Ser Ser Arg Arg Leu Asp Leu Leu His Gln Gln Leu \par
            100                 105                 110         \par
Gln Glu Leu His Ala His Val Val Leu Pro Asp Pro Ala Ala Thr \par
        115                 120                 125         \par
\par
<210> 57\par
<211> 581\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> Lg-IP3R2-Sm (LgBiT-ITPR2-IBC-SmBiT)\par
\par
<400> 57\par
Met Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Glu Gln Thr Ala \par
1               5                   10                  15      \par
Ala Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu \par
            20                  25                  30          \par
Leu Gln Asn Leu Ala Val Ser Val Thr Pro Ile Gln Arg Ile Val Arg \par
        35                  40                  45              \par
Ser Gly Glu Asn Ala Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr \par
    50                  55                  60                  \par
Glu Gly Leu Ser Ala Asp Gln Met Ala Gln Ile Glu Glu Val Phe Lys \par
65                  70                  75                  80  \par
Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu Pro Tyr \par
                85                  90                  95      \par
Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Leu Asn Tyr Phe \par
            100                 105                 110         \par
Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr \par
        115                 120                 125             \par
Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu \par
    130                 135                 140                 \par
Ile Thr Pro Asp Gly Ser Met Leu Phe Arg Val Thr Ile Asn Ser Gly \par
145                 150                 155                 160 \par
Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Thr Lys \par
                165                 170                 175     \par
Tyr Ser Ser Tyr Arg Glu Asp Val Leu Lys Gly Gly Asp Val Val Arg \par
            180                 185                 190         \par
Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu Tyr Glu \par
        195                 200                 205             \par
Lys Lys Gln His Ile Phe Leu Arg Thr Thr Leu Arg Gln Ser Ala Thr \par
    210                 215                 220                 \par
Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Ile Glu Val Val His His \par
225                 230                 235                 240 \par
Asp Pro Cys Arg Gly Gly Ala Gly Gln Trp Asn Ser Leu Phe Arg Phe \par
                245                 250                 255     \par
Lys His Leu Ala Thr Gly Asn Tyr Leu Ala Ala Glu Leu Asn Pro Asp \par
            260                 265                 270         \par
Tyr Arg Asp Ala Gln Asn Glu Gly Lys Asn Val Arg Asp Gly Val Pro \par
        275                 280                 285             \par
Pro Thr Ser Lys Lys Lys Arg Gln Ala Gly Glu Lys Ile Met Tyr Thr \par
    290                 295                 300                 \par
Leu Val Ser Val Pro His Gly Asn Asp Ile Ala Ser Leu Phe Glu Leu \par
305                 310                 315                 320 \par
Asp Ala Thr Thr Leu Gln Arg Ala Asp Cys Leu Val Pro Arg Asn Ser \par
                325                 330                 335     \par
Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val Thr Ser Thr \par
            340                 345                 350         \par
Ser Ile Pro Ile Asp Thr Asp Glu Glu Arg Pro Val Met Leu Lys Ile \par
        355                 360                 365             \par
Gly Thr Cys Gln Thr Lys Glu Asp Lys Glu Ala Phe Ala Ile Val Ser \par
    370                 375                 380                 \par
Val Pro Leu Ser Glu Val Arg Asp Leu Asp Phe Ala Asn Asp Ala Asn \par
385                 390                 395                 400 \par
Lys Val Leu Ala Thr Thr Val Lys Lys Leu Glu Asn Gly Thr Ile Thr \par
                405                 410                 415     \par
Gln Asn Glu Arg Arg Phe Val Thr Lys Leu Leu Glu Asp Leu Ile Phe \par
            420                 425                 430         \par
Phe Val Ala Asp Val Pro Asn Asn Gly Gln Glu Val Leu Asp Val Val \par
        435                 440                 445             \par
Ile Thr Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu Gln Asn \par
    450                 455                 460                 \par
Ile Leu Ala Gln Val Phe Gly Ile Leu Lys Ala Pro Phe Lys Glu Lys \par
465                 470                 475                 480 \par
Ala Gly Glu Gly Ser Met Leu Arg Leu Glu Asp Leu Gly Asp Gln Arg \par
                485                 490                 495     \par
Tyr Ala Pro Tyr Lys Tyr Met Leu Arg Leu Cys Tyr Arg Val Leu Arg \par
            500                 505                 510         \par
His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys Asn \par
        515                 520                 525             \par
Phe Cys Val Met Gln Ser Gln Ile Gly Tyr Asp Ile Leu Ala Glu Asp \par
    530                 535                 540                 \par
Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Gly Gly Ser Gly Gly \par
545                 550                 555                 560 \par
Gly Gly Ser Gly Gly Ser Ser Ser Gly Gly Val Thr Gly Tyr Arg Leu \par
                565                 570                 575     \par
Phe Glu Glu Ile Leu \par
            580     \par
\par
<210> 58\par
<211> 352\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q (\'e2\u710 \'88\u8224 \'86C)\par
\par
<400> 58\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
\par
\par
\par
<210> 59\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/s\par
\par
<400> 59\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Arg Gln Tyr Glu Leu Leu \par
        355                 \par
\par
<210> 60\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/olf\par
\par
<400> 60\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Gln Tyr Glu Leu Leu \par
        355                 \par
\par
<210> 61\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/i1\par
\par
<400> 61\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Asp Cys Gly Leu Phe \par
        355                 \par
\par
<210> 62\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/i3\par
\par
<400> 62\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Glu Cys Gly Leu Tyr \par
        355                 \par
\par
<210> 63\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/o\par
\par
<400> 63\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Arg Gly Cys Gly Leu Tyr \par
        355                 \par
\par
<210> 64\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/z\par
\par
<400> 64\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Tyr Ile Gly Leu Cys \par
        355                 \par
\par
<210> 65\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q\par
\par
<400> 65\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Glu Tyr Asn Leu Val \par
        355                 \par
\par
<210> 66\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/14\par
\par
<400> 66\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Arg Glu Phe Asn Leu Val \par
        355                 \par
\par
<210> 67\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/16\par
\par
<400> 67\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Asp Glu Ile Asn Leu Leu \par
        355                 \par
\par
<210> 68\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/12\par
\par
<400> 68\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Asp Ile Met Leu Gln \par
        355                 \par
\par
<210> 69\par
<211> 359\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1q/13\par
\par
<400> 69\par
Met Thr Leu Glu Ser Ile Met Ala Cys Cys Leu Ser Glu Glu Ala Lys \par
1               5                   10                  15      \par
Glu Ala Arg Arg Ile Asn Asp Glu Ile Glu Arg Gln Leu Arg Arg Asp \par
            20                  25                  30          \par
Lys Arg Asp Ala Arg Arg Glu Leu Lys Leu Leu Leu Leu Gly Thr Gly \par
        35                  40                  45              \par
Glu Ser Gly Lys Ser Thr Phe Ile Lys Gln Met Arg Ile Ile His Gly \par
    50                  55                  60                  \par
Ser Gly Tyr Ser Asp Glu Asp Lys Arg Gly Phe Thr Lys Leu Val Tyr \par
65                  70                  75                  80  \par
Gln Asn Ile Phe Thr Ala Met Gln Ala Met Ile Arg Ala Met Asp Thr \par
                85                  90                  95      \par
Leu Lys Ile Pro Tyr Lys Tyr Glu His Asn Lys Ala His Ala Gln Leu \par
            100                 105                 110         \par
Val Arg Glu Val Asp Val Glu Lys Val Ser Ala Phe Glu Asn Pro Tyr \par
        115                 120                 125             \par
Val Asp Ala Ile Lys Ser Leu Trp Asn Asp Pro Gly Ile Gln Glu Cys \par
    130                 135                 140                 \par
Tyr Asp Arg Arg Arg Glu Tyr Gln Leu Ser Asp Ser Thr Lys Tyr Tyr \par
145                 150                 155                 160 \par
Leu Asn Asp Leu Asp Arg Val Ala Asp Pro Ala Tyr Leu Pro Thr Gln \par
                165                 170                 175     \par
Gln Asp Val Leu Arg Val Arg Val Pro Thr Thr Gly Ile Ile Glu Tyr \par
            180                 185                 190         \par
Pro Phe Asp Leu Gln Ser Val Ile Phe Arg Met Val Asp Val Gly Gly \par
        195                 200                 205             \par
Gln Arg Ser Glu Arg Arg Lys Trp Ile His Cys Phe Glu Asn Val Thr \par
    210                 215                 220                 \par
Ser Ile Met Phe Leu Val Ala Leu Ser Glu Tyr Asp Gln Val Leu Val \par
225                 230                 235                 240 \par
Glu Ser Asp Asn Glu Asn Arg Met Glu Glu Ser Lys Ala Leu Phe Arg \par
                245                 250                 255     \par
Thr Ile Ile Thr Tyr Pro Trp Phe Gln Asn Ser Ser Val Ile Leu Phe \par
            260                 265                 270         \par
Leu Asn Lys Lys Asp Leu Leu Glu Glu Lys Ile Met Tyr Ser His Leu \par
        275                 280                 285             \par
Val Asp Tyr Phe Pro Glu Tyr Asp Gly Pro Gln Arg Asp Ala Gln Ala \par
    290                 295                 300                 \par
Ala Arg Glu Phe Ile Leu Lys Met Phe Val Asp Leu Asn Pro Asp Ser \par
305                 310                 315                 320 \par
Asp Lys Ile Ile Tyr Ser His Phe Thr Cys Ala Thr Asp Thr Glu Asn \par
                325                 330                 335     \par
Ile Arg Phe Val Phe Ala Ala Val Lys Asp Thr Ile Leu Gln Leu Asn \par
            340                 345                 350         \par
Leu Lys Gln Leu Met Leu Gln \par
        355                 \par
\par
<210> 70\par
<211> 374\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s (\'e2\u710 \'88\u8224 \'86C)\par
\par
<400> 70\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu \par
    370                 \par
\par
<210> 71\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s\par
\par
<400> 71\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Arg Gln Tyr Glu Leu Leu \par
    370                 375                 380 \par
\par
<210> 72\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/i1\par
\par
<400> 72\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Asp Cys Gly Leu Phe \par
    370                 375                 380 \par
\par
<210> 73\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/i3\par
\par
<400> 73\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Glu Cys Gly Leu Tyr \par
    370                 375                 380 \par
\par
<210> 74\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/o\par
\par
<400> 74\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Arg Gly Cys Gly Leu Tyr \par
    370                 375                 380 \par
\par
<210> 75\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/z\par
\par
<400> 75\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Tyr Ile Gly Leu Cys \par
    370                 375                 380 \par
\par
<210> 76\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/q\par
\par
<400> 76\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Glu Tyr Asn Leu Val \par
    370                 375                 380 \par
\par
<210> 77\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/14\par
\par
<400> 77\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Arg Glu Phe Asn Leu Val \par
    370                 375                 380 \par
\par
<210> 78\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/16\par
\par
<400> 78\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Asp Glu Ile Asn Leu Leu \par
    370                 375                 380 \par
\par
<210> 79\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/12\par
\par
<400> 79\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Asp Ile Met Leu Gln \par
    370                 375                 380 \par
\par
<210> 80\par
<211> 380\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> G\'ce\'b1s/13\par
\par
<400> 80\par
Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu \par
1               5                   10                  15      \par
Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys \par
            20                  25                  30          \par
Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala \par
        35                  40                  45              \par
Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His \par
    50                  55                  60                  \par
Val Asn Gly Phe Asn Gly Asp Ser Glu Lys Ala Thr Lys Val Gln Asp \par
65                  70                  75                  80  \par
Ile Lys Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met \par
                85                  90                  95      \par
Ser Asn Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe \par
            100                 105                 110         \par
Arg Val Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe \par
        115                 120                 125             \par
Pro Pro Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly \par
    130                 135                 140                 \par
Val Arg Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys \par
145                 150                 155                 160 \par
Ala Gln Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr \par
                165                 170                 175     \par
Val Pro Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly \par
            180                 185                 190         \par
Ile Phe Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe \par
        195                 200                 205             \par
Asp Val Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe \par
    210                 215                 220                 \par
Asn Asp Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn \par
225                 230                 235                 240 \par
Met Val Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu \par
                245                 250                 255     \par
Asn Leu Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser \par
            260                 265                 270         \par
Val Ile Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu \par
        275                 280                 285             \par
Ala Gly Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr \par
    290                 295                 300                 \par
Thr Thr Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val \par
305                 310                 315                 320 \par
Thr Arg Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr \par
                325                 330                 335     \par
Ala Ser Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala \par
            340                 345                 350         \par
Val Asp Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile \par
        355                 360                 365             \par
Ile Gln Arg Met His Leu Lys Gln Leu Met Leu Gln \par
    370                 375                 380 \par
\par
<210> 81\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/s\par
\par
<400> 81\par
Arg Gln Tyr Glu Leu Leu \par
1               5       \par
\par
<210> 82\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/olf, G\'ce\'b1s/olf\par
\par
<400> 82\par
Lys Gln Tyr Glu Leu Leu \par
1               5       \par
\par
<210> 83\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/i1, G\'ce\'b1s/i1\par
\par
<400> 83\par
Lys Asp Cys Gly Leu Phe \par
1               5       \par
\par
<210> 84\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/i3, G\'ce\'b1s/i3\par
\par
<400> 84\par
Lys Glu Cys Gly Leu Tyr \par
1               5       \par
\par
<210> 85\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/o, G\'ce\'b1s/o\par
\par
<400> 85\par
Arg Gly Cys Gly Leu Tyr \par
1               5       \par
\par
<210> 86\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/z, G\'ce\'b1s/z\par
\par
<400> 86\par
Lys Tyr Ile Gly Leu Cys \par
1               5       \par
\par
<210> 87\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/14, G\'ce\'b1s/14\par
\par
<400> 87\par
Arg Glu Phe Asn Leu Val \par
1               5       \par
\par
<210> 88\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/16, G\'ce\'b1s/16\par
\par
<400> 88\par
Asp Glu Ile Asn Leu Leu \par
1               5       \par
\par
<210> 89\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/12\par
\par
<400> 89\par
Lys Asp Ile Met Leu Gln \par
1               5       \par
\par
<210> 90\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1q/13, G\'ce\'b1s/13\par
\par
<400> 90\par
Lys Gln Leu Met Leu Gln \par
1               5       \par
\par
<210> 91\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1s/q\par
\par
<400> 91\par
Lys Glu Tyr Asn Leu Val \par
1               5       \par
\par
<210> 92\par
<211> 6\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> C-terminally substituted 6-amino acids of G\'ce\'b1s/12\par
\par
<400> 92\par
Lys Asp Ile Met Leu Gln \par
1               5       \par
\par
<210> 93\par
<211> 651\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> amino acid sequence of the AP-TGF\'ce\'b1.\par
\par
<400> 93\par
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val \par
1               5                   10                  15      \par
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala \par
            20                  25                  30          \par
Asp Pro Pro Val Ala Ala Ala Val Val Ser Arg Ser Gly Ile Ile Pro \par
        35                  40                  45              \par
Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu Ala Ala Glu Ala \par
    50                  55                  60                  \par
Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr Ala Ala Lys Asn \par
65                  70                  75                  80  \par
Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser Thr Val Thr Ala \par
                85                  90                  95      \par
Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu Gly Pro Glu Ile \par
            100                 105                 110         \par
Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr \par
        115                 120                 125             \par
Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr Ala Thr Ala Tyr \par
    130                 135                 140                 \par
Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly Leu Ser Ala Ala \par
145                 150                 155                 160 \par
Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn Glu Val Ile Ser \par
                165                 170                 175     \par
Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val Gly Val Val Thr \par
            180                 185                 190         \par
Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr Tyr Ala His Thr \par
        195                 200                 205             \par
Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro Ala Ser Ala Arg \par
    210                 215                 220                 \par
Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile Ser Asn Met Asp \par
225                 230                 235                 240 \par
Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met Phe Arg Met Gly \par
                245                 250                 255     \par
Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln Gly Gly Thr Arg \par
            260                 265                 270         \par
Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala Lys Arg Gln Gly \par
        275                 280                 285             \par
Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln Ala Ser Leu Asp \par
    290                 295                 300                 \par
Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro Gly Asp Met Lys \par
305                 310                 315                 320 \par
Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser Leu Met Glu Met \par
                325                 330                 335     \par
Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro Arg Gly Phe Phe \par
            340                 345                 350         \par
Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Ser Arg \par
        355                 360                 365             \par
Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp Asp Ala Ile Glu \par
    370                 375                 380                 \par
Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu Ser Leu Val Thr \par
385                 390                 395                 400 \par
Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr Pro Leu Arg Gly \par
                405                 410                 415     \par
Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg Asp Arg Lys Ala \par
            420                 425                 430         \par
Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr Val Leu Lys Asp \par
        435                 440                 445             \par
Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly Ser Pro Glu Tyr \par
    450                 455                 460                 \par
Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr His Ala Gly Glu \par
465                 470                 475                 480 \par
Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His Leu Val His Gly \par
                485                 490                 495     \par
Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala Phe Ala Ala Cys \par
            500                 505                 510         \par
Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro Ala Gly Thr Thr \par
        515                 520                 525             \par
Asp Ala Ala His Pro Gly Tyr His Asp Cys Pro Asp Ser His Thr Gln \par
    530                 535                 540                 \par
Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro \par
545                 550                 555                 560 \par
Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala \par
                565                 570                 575     \par
Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys Gln Ala Ile Thr \par
            580                 585                 590         \par
Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val Leu Ile Ile Thr \par
        595                 600                 605             \par
Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His Cys Glu Trp Cys \par
    610                 615                 620                 \par
Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala Leu Leu Lys Gly \par
625                 630                 635                 640 \par
Arg Thr Ala Cys Cys His Ser Glu Thr Val Val \par
                645                 650     \par
\par
<210> 94\par
<211> 39\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> signal-sequence peptide and the cleaved fragment of human TGFA\par
\par
<400> 94\par
Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val \par
1               5                   10                  15      \par
Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Ala \par
            20                  25                  30          \par
Asp Pro Pro Val Ala Ala Ala \par
        35                  \par
\par
<210> 95\par
<211> 489\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> alkaline phosphatase sequence derived from human ALPP\par
\par
<400> 95\par
Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn Arg Glu \par
1               5                   10                  15      \par
Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala Gln Thr \par
            20                  25                  30          \par
Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly Val Ser \par
        35                  40                  45              \par
Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp Lys Leu \par
    50                  55                  60                  \par
Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe Pro Tyr Val Ala Leu \par
65                  70                  75                  80  \par
Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro Asp Ser Gly Ala Thr \par
                85                  90                  95      \par
Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr Ile Gly \par
            100                 105                 110         \par
Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg Gly Asn \par
        115                 120                 125             \par
Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys Ser Val \par
    130                 135                 140                 \par
Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala Gly Thr \par
145                 150                 155                 160 \par
Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp Val Pro \par
                165                 170                 175     \par
Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln Leu Ile \par
            180                 185                 190         \par
Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys Tyr Met \par
        195                 200                 205             \par
Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr Ser Gln \par
    210                 215                 220                 \par
Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp Leu Ala \par
225                 230                 235                 240 \par
Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu Met Gln \par
                245                 250                 255     \par
Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe Glu Pro \par
            260                 265                 270         \par
Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp Pro Ser \par
        275                 280                 285             \par
Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg Asn Pro \par
    290                 295                 300                 \par
Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His Gly His \par
305                 310                 315                 320 \par
His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met Phe Asp \par
                325                 330                 335     \par
Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp Thr Leu \par
            340                 345                 350         \par
Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly Gly Tyr \par
        355                 360                 365             \par
Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys Ala Arg \par
    370                 375                 380                 \par
Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro Gly Tyr \par
385                 390                 395                 400 \par
Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu Ser Gly \par
                405                 410                 415     \par
Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Glu Glu Thr \par
            420                 425                 430         \par
His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln Ala His \par
        435                 440                 445             \par
Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val Met Ala \par
    450                 455                 460                 \par
Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala Pro Pro \par
465                 470                 475                 480 \par
Ala Gly Thr Thr Asp Ala Ala His Pro \par
                485                 \par
\par
<210> 96\par
<211> 48\par
<212> PRT\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> mature, ectodomain-shed fragment of human TGFA\par
\par
<400> 96\par
Gly Tyr His Asp Cys Pro Asp Ser His Thr Gln Phe Cys Phe His Gly \par
1               5                   10                  15      \par
Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys Val Cys His \par
            20                  25                  30          \par
Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu Leu Ala Val \par
        35                  40                  45              \par
\par
\par
\par
<210> 97\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNAQHSS104236\par
\par
<400> 97\par
ggagagagug gcaagaguac guuua                                          25\par
\par
\par
<210> 98\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNAQHSS104237\par
\par
<400> 98\par
cccuuugacu uacaaagugu cauuu                                          25\par
\par
\par
<210> 99\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA11HSS178464\par
\par
<400> 99\par
ccggcaucau cgaguacccu uucga                                          25\par
\par
\par
<210> 100\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA11HSS104213\par
\par
<400> 100\par
gcaucaguac gucagugcca ucaag                                          25\par
\par
\par
<210> 101\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA12MSS204749\par
\par
<400> 101\par
ccaucgucaa caacaagcuc uucuu                                          25\par
\par
\par
<210> 102\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA13-HSS173827\par
\par
<400> 102\par
cagaagcccu uauaccacca cuuca                                          25\par
\par
\par
<210> 103\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA13-HSS116479\par
\par
<400> 103\par
gcagcccaag gaauggugga aacaa                                          25\par
\par
\par
<210> 104\par
<211> 25\par
<212> RNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> ADAM17-HSS186181\par
\par
<400> 104\par
cagaaucgug uugacagcaa agaaa                                          25\par
\par
\par
<210> 105\par
<211> 21\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNAQ_1\par
\par
<400> 105\par
accgaatgga ggaaagcaag g                                              21\par
\par
\par
<210> 106\par
<211> 25\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNAQ2\par
\par
<400> 106\par
catctctctg gggtccatca tattc                                          25\par
\par
\par
<210> 107\par
<211> 20\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA11_1\par
\par
<400> 107\par
cagcgaatac gaccaagtcc                                                20\par
\par
\par
<210> 108\par
<211> 20\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA11_2\par
\par
<400> 108\par
accaggggta ggtgatgatg                                                20\par
\par
\par
<210> 109\par
<211> 19\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA12_1\par
\par
<400> 109\par
gagggattct ggcatcagg                                                 19\par
\par
\par
<210> 110\par
<211> 19\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA12_2\par
\par
<400> 110\par
cgatccggtc caagttgtc                                                 19\par
\par
\par
<210> 111\par
<211> 24\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA13_1\par
\par
<400> 111\par
cctggataac ttggataaac ttgg                                           24\par
\par
\par
<210> 112\par
<211> 19\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GNA13_2\par
\par
<400> 112\par
ttcatggatg cctttggtg                                                 19\par
\par
\par
<210> 113\par
<211> 22\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GAPDH_1\par
\par
<400> 113\par
gccaaggtca tccatgacaa ct                                             22\par
\par
\par
<210> 114\par
<211> 20\par
<212> DNA\par
<213> Homo sapiens\par
\par
\par
<220> \par
<223> GADPH_2\par
\par
<400> 114\par
gaggggccat ccacagtctt                                                20\par
\par
\par
}
