                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
       Universite de Montpellier
 
<120>  Method for identifying ubiquitin and ubiquitin-like enzyme 
       activities

<130>  BR112490/RIM

<150>  EP19305690.0
<151>  2019-05-29

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Lys Cys Ser Val Gly Gly Leu Glu Leu Thr Glu Gln Thr Pro 
1               5                   10                  15      


Ala Leu Leu Gly Asn Met Ala Met Ala Thr Ser Leu Met Asp Ile Gly 
            20                  25                  30          


Asp Ser Phe Gly His Pro Ala Cys Pro Leu Val Ser Arg Ser Arg Asn 
        35                  40                  45              


Ser Pro Val Glu Asp Asp Asp Asp Asp Asp Asp Val Val Phe Ile Glu 
    50                  55                  60                  


Ser Ile Gln Pro Pro Ser Ile Ser Ala Pro Ala Ile Ala Asp Gln Arg 
65                  70                  75                  80  


Asn Phe Ile Phe Ala Ser Ser Lys Asn Glu Lys Pro Gln Gly Asn Tyr 
                85                  90                  95      


Ser Val Ile Pro Pro Ser Ser Arg Asp Leu Ala Ser Gln Lys Gly Asn 
            100                 105                 110         


Ile Ser Glu Thr Ile Val Ile Asp Asp Glu Glu Asp Val Glu Thr Asn 
        115                 120                 125             


Gly Gly Ala Glu Lys Lys Ser Ser Phe Phe Ile Glu Trp Gly Leu Pro 
    130                 135                 140                 


Gly Thr Lys Asn Lys Thr Asn Asp Leu Asp Phe Ser Thr Ser Ser Leu 
145                 150                 155                 160 


Ser Arg Ser Lys Thr Lys Thr Gly Val Arg Pro Phe Asn Pro Gly Arg 
                165                 170                 175     


Met Asn Val Ala Gly Asp Leu Phe Gln Asn Gly Glu Phe Ala Thr His 
            180                 185                 190         


His Ser Pro Glu Met His Leu Gln Arg Arg Leu Met Ser Phe Phe Gln 
        195                 200                 205             


<210>  2
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Tyr Ala Cys Ser Ser Ser Glu Asp Trp Pro Pro Pro Leu Asp 
1               5                   10                  15      


Ile Ser Ser Asp Gly Asp Val Asp Ala Thr Val Leu Arg Glu Leu Tyr 
            20                  25                  30          


Pro Asp Ser Pro Pro Gly Tyr Glu Glu Cys Val Gly Pro Gly Ala Thr 
        35                  40                  45              


Gln Leu Tyr Val Pro Thr Asp Ala Pro Pro Pro Tyr Ser Leu Thr Asp 
    50                  55                  60                  


Ser Cys Pro Thr Leu Asp Gly Thr Ser Asp Ser Gly Ser Gly His Ser 
65                  70                  75                  80  


Pro Gly Arg His Gln Gln Glu Gln Arg Thr Pro Ala Gln Gly Gly Leu 
                85                  90                  95      


His Thr Val Ser Met Asp Thr Leu Pro Pro Tyr Glu Ala Val Cys Gly 
            100                 105                 110         


Ala Gly Pro Pro Ser Gly Leu Leu Pro Leu Pro Gly Pro Asp Pro Gly 
        115                 120                 125             


Pro Arg Gly Ser Gln Gly Ser Pro Thr Pro Thr Arg Ala Pro Ala Ser 
    130                 135                 140                 


Gly Pro Glu Arg Ile Val 
145                 150 


<210>  3
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Ala Val Leu Thr Glu Glu Leu Asp Glu Glu Glu Gln Leu Leu 
1               5                   10                  15      


Arg Arg His Arg Lys Glu Lys Lys Glu Leu Gln Ala Lys Ile Gln Gly 
            20                  25                  30          


Met Lys Asn Ala Val Pro Lys Asn Asp Lys Lys Arg Arg Lys Gln Leu 
        35                  40                  45              


Thr Glu Asp Val Ala Lys Leu Glu Lys Glu Met Glu Gln Lys His Arg 
    50                  55                  60                  


Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu Asn Lys Ile Asp 
65                  70                  75                  80  


Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu Asn Gln Pro Pro 
                85                  90                  95      


Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys Ala Ala Leu Glu 
            100                 105                 110         


Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile Glu Asn Leu Thr 
        115                 120                 125             


Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln Ile Leu Ala Ala 
    130                 135                 140                 


Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly His Cys Met Tyr 
145                 150                 155                 160 


Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys Ala Leu Thr Val 
                165                 170                 175     


Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln Ser His Val Glu 
            180                 185                 190         


Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly Asp Met Tyr Thr 
        195                 200                 205             


Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val Asn Thr Ala Ala 
    210                 215                 220                 


Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His Ile Leu Gln Thr 
225                 230                 235                 240 


Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile Ile Val Gly Glu 
                245                 250                 255     


Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met Arg His Ala Tyr 
            260                 265                 270         


Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Val Asn Ile Val 
        275                 280                 285             


Thr Glu Asn Cys Ser 
    290             


<210>  4
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Thr Pro Arg Pro Cys Ala Asp Gly Pro Cys Cys Ser His Pro 
1               5                   10                  15      


Ser Ala Val Leu Gly Val Gln Gln Thr Leu Glu Glu Met Asp Phe Glu 
            20                  25                  30          


Arg Gly Ile Trp Ser Ala Ala Leu Asn Gly Asp Leu Gly Arg Val Lys 
        35                  40                  45              


His Leu Ile Gln Lys Ala Glu Asp Pro Ser Gln Pro Asp Ser Ala Gly 
    50                  55                  60                  


Tyr Thr Ala Leu His Tyr Ala Ser Arg Asn Gly His Tyr Ala Val Cys 
65                  70                  75                  80  


Gln Phe Leu Leu Glu Ser Gly Ala Lys Cys Asp Ala Gln Thr His Gly 
                85                  90                  95      


Gly Ala Thr Ala Leu His Arg Ala Ser Tyr Cys Gly His Thr Glu Ile 
            100                 105                 110         


Thr Arg Leu Leu Leu Ser His Gly Ser Asn Pro Arg Val Val Asp Asp 
        115                 120                 125             


Asp Gly Met Thr Ser Leu His Lys Ala Ala Glu Arg Gly His Gly Asp 
    130                 135                 140                 


Ile Cys Ser Leu Leu Leu Gln His Ser Pro Ala Leu Lys Ala Ile Arg 
145                 150                 155                 160 


Asp Arg Lys Ala Arg Leu Ala Cys Asp Leu Leu Pro Cys Asn Ser Asp 
                165                 170                 175     


Leu Arg Asp Leu Leu Ser Ser 
            180             


<210>  5
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Trp Leu Leu Gly Pro Leu Cys Leu Leu Leu Ser Ser Ala Ala Glu 
1               5                   10                  15      


Ser Gln Leu Leu Pro Gly Asn Asn Phe Thr Asn Glu Cys Asn Ile Pro 
            20                  25                  30          


Gly Asn Phe Met Cys Ser Asn Gly Arg Cys Ile Pro Gly Ala Trp Gln 
        35                  40                  45              


Cys Asp Gly Leu Pro Asp Cys Phe Asp Lys Ser Asp Glu Lys Glu Cys 
    50                  55                  60                  


Pro Lys Ala Lys Ser Lys Cys Gly Pro Thr Phe Phe Pro Cys Ala Ser 
65                  70                  75                  80  


Gly Ile His Cys Ile Ile Gly Arg Phe Arg Cys Asn Gly Phe Glu Asp 
                85                  90                  95      


Cys Pro Asp Gly Ser Asp Glu Glu Asn Cys Thr Ala Asn Pro Leu Leu 
            100                 105                 110         


Cys Ser Thr Ala Arg Tyr His Cys Lys Asn Gly Leu Cys Ile Asp Lys 
        115                 120                 125             


Ser Phe Ile Cys Asp Gly Gln Asn Asn Cys Gln Asp Asn Ser Asp Glu 
    130                 135                 140                 


Glu Ser Cys Glu Ser Ser Gln Glu Pro Gly Ser Gly Gln Val Phe Val 
145                 150                 155                 160 


Thr Ser Glu Asn Gln Leu Val Tyr Tyr Pro Ser Ile Thr Tyr Ala Ile 
                165                 170                 175     


Ile Gly Ser Ser Val Ile Phe Val Leu Val Val Ala Leu Leu Ala Leu 
            180                 185                 190         


Val Leu His His Gln Arg Lys Arg Asn Asn Leu Met Thr Leu Pro Val 
        195                 200                 205             


His Arg Leu Gln His Pro Val Leu Leu Ser Arg Leu Val Val Leu Asp 
    210                 215                 220                 


His Pro His His Cys Asn Val Thr Tyr Asn Val Asn Asn Gly Ile Gln 
225                 230                 235                 240 


Tyr Val Ala Ser Gln Ala Glu Gln Asn Ala Ser Glu Val Gly Ser Pro 
                245                 250                 255     


Pro Ser Tyr Ser Glu Ala Leu Leu Asp Gln Arg Pro Ala Trp Tyr Asp 
            260                 265                 270         


Leu Pro Pro Pro Pro Tyr Ser Ser Asp Thr Glu Ser Leu Asn Gln Ala 
        275                 280                 285             


Asp Leu Pro Pro Tyr Arg Ser Arg Ser Gly Ser Ala Asn Ser Ala Ser 
    290                 295                 300                 


Ser Gln Ala Ala Ser Ser Leu Leu Ser Val Glu Asp Thr Ser His Ser 
305                 310                 315                 320 


Pro Gly Gln Pro Gly Pro Gln Glu Gly Thr Ala Glu Pro Arg Asp Ser 
                325                 330                 335     


Glu Pro Ser Gln Gly Thr Glu Glu Val 
            340                 345 


<210>  6
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Arg Val Lys Met Ile Asn Val Gln Arg Leu Leu Glu Ala Ala 
1               5                   10                  15      


Glu Phe Leu Glu Arg Arg Glu Arg Glu Cys Glu His Gly Tyr Ala Ser 
            20                  25                  30          


Ser Phe Pro Ser Met Pro Ser Pro Arg Leu Gln His Ser Lys Pro Pro 
        35                  40                  45              


Arg Arg Leu Ser Arg Ala Gln Lys His Ser Ser Gly Ser Ser Asn Thr 
    50                  55                  60                  


Ser Thr Ala Asn Arg Ser Thr His Asn Glu Leu Glu Lys Asn Arg Arg 
65                  70                  75                  80  


Ala His Leu Arg Leu Cys Leu Glu Arg Leu Lys Val Leu Ile Pro Leu 
                85                  90                  95      


Gly Pro Asp Cys Thr Arg His Thr Thr Leu Gly Leu Leu Asn Lys Ala 
            100                 105                 110         


Lys Ala His Ile Lys Lys Leu Glu Glu Ala Glu Arg Lys Ser Gln His 
        115                 120                 125             


Gln Leu Glu Asn Leu Glu Arg Glu Gln Arg Phe Leu Lys Trp Arg Leu 
    130                 135                 140                 


Glu Gln Leu Gln Gly Pro Gln Glu Met Glu Arg Ile Arg Met Asp Ser 
145                 150                 155                 160 


Ile Gly Ser Thr Ile Ser Ser Asp Arg Ser Asp Ser Glu Arg Glu Glu 
                165                 170                 175     


Ile Glu Val Asp Val Glu Ser Thr Glu Phe Ser His Gly Glu Val Asp 
            180                 185                 190         


Asn Ile Ser Thr Thr Ser Ile Ser Asp Ile Asp Asp His Ser Ser Leu 
        195                 200                 205             


Pro Ser Ile Gly Ser Asp Glu Gly Tyr Ser Ser Ala Ser Val Lys Leu 
    210                 215                 220                 


Ser Phe Thr Ser 
225             


<210>  7
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Val Tyr Glu Lys Tyr Thr Gly Ser Val Gly Gly Thr His Asp Met 
1               5                   10                  15      


Ile Cys Glu Tyr His His Leu Cys Gln Thr Ser Leu Gln Gly Ile Pro 
            20                  25                  30          


Val Ser Gln Leu Lys Gly Val Asn Gly His Thr His Ser Leu Asp Asp 
        35                  40                  45              


Ala Leu Ala Val Leu Arg Gly Cys Lys Val Gly Ser Gly Pro Ser Ser 
    50                  55                  60                  


<210>  8
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Gln Ala Trp Val Pro Gly Leu Ala Pro Thr Leu Leu Phe Ser 
1               5                   10                  15      


Leu Leu Ala Gly Pro Gln Lys Ile Ala Ala Lys Cys Gly Leu Ile Leu 
            20                  25                  30          


Ala Cys Pro Lys Gly Phe Lys Cys Cys Gly Asp Ser Cys Cys Gln Glu 
        35                  40                  45              


Asn Glu Leu Phe Pro Gly Pro Val Arg Ile Phe Val Ile Ile Phe Leu 
    50                  55                  60                  


Val Ile Leu Ser Val Phe Cys Ile Cys Gly Leu Ala Lys Cys Phe Cys 
65                  70                  75                  80  


Arg Asn Cys Arg Glu Pro Glu Pro Asp Thr Pro Val Asp Cys Arg Gly 
                85                  90                  95      


Pro Leu Glu Leu Pro Ser Ile Ile Pro Pro Glu Arg Val Arg Val Ser 
            100                 105                 110         


Leu Ser Ala Pro Pro Pro Pro Tyr Ser Glu Val Ile Leu Lys Pro Ser 
        115                 120                 125             


Leu Gly Pro Thr Pro Thr Glu Pro Pro Pro Pro Tyr Ser Phe Arg Pro 
    130                 135                 140                 


Glu Glu Tyr Thr Gly Asp Gln Arg Gly Ile Asp Asn Pro Ala Phe 
145                 150                 155                 


<210>  9
<211>  872
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Thr Ala Cys Lys Arg Ser Gly Glu Pro Gln Ser Asp Asp Ile 
1               5                   10                  15      


Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu Ile Glu Arg 
            20                  25                  30          


Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala Cys Thr Asn 
        35                  40                  45              


Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp Asn Asn Ala 
    50                  55                  60                  


Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala Lys Leu Cys 
65                  70                  75                  80  


Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr Leu Glu Asn 
                85                  90                  95      


Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys Met Asn Lys 
            100                 105                 110         


Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu Thr Glu Glu 
        115                 120                 125             


Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu Asp Tyr Ser 
    130                 135                 140                 


Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala Glu Ala Leu 
145                 150                 155                 160 


Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu Glu Leu Lys 
                165                 170                 175     


Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu Lys Glu Lys 
            180                 185                 190         


Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu Ala Ser Ser 
        195                 200                 205             


Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu Gln Lys Leu 
    210                 215                 220                 


Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg Arg Val Tyr 
225                 230                 235                 240 


Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe Leu Asn Ala 
                245                 250                 255     


Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr Tyr His Asn 
            260                 265                 270         


Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile Ile Val Met 
        275                 280                 285             


Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met Ala Leu Pro 
    290                 295                 300                 


Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala Gln Gly Lys 
305                 310                 315                 320 


Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile Arg Arg Met 
                325                 330                 335     


Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile Ser Asn Glu 
            340                 345                 350         


Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile Val Ala Ala 
        355                 360                 365             


Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val Gly Gly Glu 
    370                 375                 380                 


Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro Ile Pro Glu 
385                 390                 395                 400 


Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu Arg Arg Asn 
                405                 410                 415     


Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu Gly Val Lys 
            420                 425                 430         


Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu Phe Ile Asn 
        435                 440                 445             


Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr Thr Phe Phe 
    450                 455                 460                 


Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys Pro Phe Ile 
465                 470                 475                 480 


Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp Asn Arg Ile 
                485                 490                 495     


Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser Leu Val Gln 
            500                 505                 510         


Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg Arg Asp His 
        515                 520                 525             


Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala Met Glu Asn 
    530                 535                 540                 


Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu Gly Glu Gln 
545                 550                 555                 560 


Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln Leu Val Val 
                565                 570                 575     


Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr Asp Glu Ser 
            580                 585                 590         


Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr Glu Gly Gln 
        595                 600                 605             


Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr Asn Asn Cys 
    610                 615                 620                 


Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys Leu Met Gly 
625                 630                 635                 640 


Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro Val Leu Tyr 
                645                 650                 655     


Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val Glu Asp Asp 
            660                 665                 670         


Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe Gly Asn Pro 
        675                 680                 685             


Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro Ile Thr Asn 
    690                 695                 700                 


Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr Ile Leu Asn 
705                 710                 715                 720 


Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly Phe His Met 
                725                 730                 735     


Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro Glu Glu Ile 
            740                 745                 750         


Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Gly Phe Gln Ala Leu Glu 
        755                 760                 765             


Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser Val Leu Ile 
    770                 775                 780                 


Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu Gln Lys Arg 
785                 790                 795                 800 


Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro Val Gly Gly 
                805                 810                 815     


Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro Asp Thr Glu 
            820                 825                 830         


Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu Leu Pro Glu 
        835                 840                 845             


Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys Ala Ile Thr 
    850                 855                 860                 


Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870         


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Leu Asn Lys Asn His Ser Glu Gly Gly Gly Val Ile Val Asn 
1               5                   10                  15      


Asn Thr Glu Ser Ile Leu Met Ser Tyr Asp His Val Glu Leu Thr Phe 
            20                  25                  30          


Asn Asp Met Lys Asn Val Pro Glu Ala Phe Lys Gly Thr Lys Lys Gly 
        35                  40                  45              


Thr Val Tyr Leu Thr Pro Tyr Arg Val Ile Phe Leu Ser Lys Gly Lys 
    50                  55                  60                  


Asp Ala Met Gln Ser Phe Met Met Pro Phe Tyr Leu Met Lys Asp Cys 
65                  70                  75                  80  


Glu Ile Lys Gln Pro Val Phe Gly Ala Asn Tyr Ile Lys Gly Thr Val 
                85                  90                  95      


Lys Ala Glu Ala Gly Gly Gly Trp Glu Gly Ser Ala Ser Tyr Lys Leu 
            100                 105                 110         


Thr Phe Thr Ala Gly Gly Ala Ile Glu Phe Gly Gln Arg Met Leu Gln 
        115                 120                 125             


Val Ala Ser Gln Ala Ser Arg Gly Glu Val Pro Ser Gly Ala Tyr Gly 
    130                 135                 140                 


Tyr Ser Tyr Met Pro Ser Gly Ala Tyr Val Tyr Pro Pro Pro Val Ala 
145                 150                 155                 160 


Asn Gly Met Tyr Pro Cys Pro Pro Gly Tyr Pro Tyr Pro Pro Pro Pro 
                165                 170                 175     


Pro Glu Phe Tyr Pro Gly Pro Pro Met Met Asp Gly Ala Met Gly Tyr 
            180                 185                 190         


Val Gln Pro Pro Pro Pro Pro Tyr Pro Gly Pro Met Glu Pro Pro Val 
        195                 200                 205             


Ser Gly Pro Asp Val Pro Ser Thr Pro Ala Ala Glu Ala Lys Ala Ala 
    210                 215                 220                 


Glu Ala Ala Ala Ser Ala Tyr Tyr Asn Pro Gly Asn Pro His Asn Val 
225                 230                 235                 240 


Tyr Met Pro Thr Ser Gln Pro Pro Pro Pro Pro Tyr Tyr Pro Pro Glu 
                245                 250                 255     


Asp Lys Lys Thr Gln 
            260     


<210>  11
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Arg Val Gln Leu Phe Glu Ile Ser Leu Ser His Gly Arg Val 
1               5                   10                  15      


Val Tyr Ser Pro Gly Glu Pro Leu Ala Gly Thr Val Arg Val Arg Leu 
            20                  25                  30          


Gly Ala Pro Leu Pro Phe Arg Ala Ile Arg Val Thr Cys Ile Gly Ser 
        35                  40                  45              


Cys Gly Val Ser Asn Lys Ala Asn Asp Thr Ala Trp Val Val Glu Glu 
    50                  55                  60                  


Gly Tyr Phe Asn Ser Ser Leu Ser Leu Ala Asp Lys Gly Ser Leu Pro 
65                  70                  75                  80  


Ala Gly Glu His Ser Phe Pro Phe Gln Phe Leu Leu Pro Ala Thr Ala 
                85                  90                  95      


Pro Thr Ser Phe Glu Gly Pro Phe Gly Lys Ile Val His Gln Val Arg 
            100                 105                 110         


Ala Ala Ile His Thr Pro Arg Phe Ser Lys Asp His Lys Cys Ser Leu 
        115                 120                 125             


Val Phe Tyr Ile Leu Ser Pro Leu Asn Leu Asn Ser Ile Pro Asp Ile 
    130                 135                 140                 


Glu Gln Pro Asn Val Ala Ser Ala Thr Lys Lys Phe Ser Tyr Lys Leu 
145                 150                 155                 160 


Val Lys Thr Gly Ser Val Val Leu Thr Ala Ser Thr Asp Leu Arg Gly 
                165                 170                 175     


Tyr Val Val Gly Gln Ala Leu Gln Leu His Ala Asp Val Glu Asn Gln 
            180                 185                 190         


Ser Gly Lys Asp Thr Ser Pro Val Val Ala Ser Leu Leu Gln Lys Val 
        195                 200                 205             


Ser Tyr Lys Ala Lys Arg Trp Ile His Asp Val Arg Thr Ile Ala Glu 
    210                 215                 220                 


Val Glu Gly Ala Gly Val Lys Ala Trp Arg Arg Ala Gln Trp His Glu 
225                 230                 235                 240 


Gln Ile Leu Val Pro Ala Leu Pro Gln Ser Ala Leu Pro Gly Cys Ser 
                245                 250                 255     


Leu Ile His Ile Asp Tyr Tyr Leu Gln Val Ser Leu Lys Ala Pro Glu 
            260                 265                 270         


Ala Thr Val Thr Leu Pro Val Phe Ile Gly Asn Ile Ala Val Asn His 
        275                 280                 285             


Ala Pro Val Ser Pro Arg Pro Gly Leu Gly Leu Pro Pro Gly Ala Pro 
    290                 295                 300                 


Pro Leu Val Val Pro Ser Ala Pro Pro Gln Glu Glu Ala Glu Ala Glu 
305                 310                 315                 320 


Ala Ala Ala Gly Gly Pro His Phe Leu Asp Pro Val Phe Leu Ser Thr 
                325                 330                 335     


Lys Ser His Ser Gln Arg Gln Pro Leu Leu Ala Thr Leu Ser Ser Val 
            340                 345                 350         


Pro Gly Ala Pro Glu Pro Cys Pro Gln Asp Gly Ser Pro Ala Ser His 
        355                 360                 365             


Pro Leu His Pro Pro Leu Cys Ile Ser Thr Gly Ala Thr Val Pro Tyr 
    370                 375                 380                 


Phe Ala Glu Gly Ser Gly Gly Pro Val Pro Thr Thr Ser Thr Leu Ile 
385                 390                 395                 400 


Leu Pro Pro Glu Tyr Ser Ser Trp Gly Tyr Pro Tyr Glu Ala Pro Pro 
                405                 410                 415     


Ser Tyr Glu Gln Ser Cys Gly Gly Val Glu Pro Ser Leu Thr Pro Glu 
            420                 425                 430         


Ser 
    


<210>  12
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Leu Gly Lys Val Lys Ser Leu Thr Ile Ser Phe Asp Cys Leu 
1               5                   10                  15      


Asn Asp Ser Asn Val Pro Val Tyr Ser Ser Gly Asp Thr Val Ser Gly 
            20                  25                  30          


Arg Val Asn Leu Glu Val Thr Gly Glu Ile Arg Val Lys Ser Leu Lys 
        35                  40                  45              


Ile His Ala Arg Gly His Ala Lys Val Arg Trp Thr Glu Ser Arg Asn 
    50                  55                  60                  


Ala Gly Ser Asn Thr Ala Tyr Thr Gln Asn Tyr Thr Glu Glu Val Glu 
65                  70                  75                  80  


Tyr Phe Asn His Lys Asp Ile Leu Ile Gly His Glu Arg Asp Asp Asp 
                85                  90                  95      


Asn Ser Glu Glu Gly Phe His Thr Ile His Ser Gly Arg His Glu Tyr 
            100                 105                 110         


Ala Phe Ser Phe Glu Leu Pro Gln Thr Pro Leu Ala Thr Ser Phe Glu 
        115                 120                 125             


Gly Arg His Gly Ser Val Arg Tyr Trp Val Lys Ala Glu Leu His Arg 
    130                 135                 140                 


Pro Trp Leu Leu Pro Val Lys Leu Lys Lys Glu Phe Thr Val Phe Glu 
145                 150                 155                 160 


His Ile Asp Ile Asn Thr Pro Ser Leu Leu Ser Pro Gln Ala Gly Thr 
                165                 170                 175     


Lys Glu Lys Thr Leu Cys Cys Trp Phe Cys Thr Ser Gly Pro Ile Ser 
            180                 185                 190         


Leu Ser Ala Lys Ile Glu Arg Lys Gly Tyr Thr Pro Gly Glu Ser Ile 
        195                 200                 205             


Gln Ile Phe Ala Glu Ile Glu Asn Cys Ser Ser Arg Met Val Val Pro 
    210                 215                 220                 


Lys Ala Ala Ile Tyr Gln Thr Gln Ala Phe Tyr Ala Lys Gly Lys Met 
225                 230                 235                 240 


Lys Glu Val Lys Gln Leu Val Ala Asn Leu Arg Gly Glu Ser Leu Ser 
                245                 250                 255     


Ser Gly Lys Thr Glu Thr Trp Asn Gly Lys Leu Leu Lys Ile Pro Pro 
            260                 265                 270         


Val Ser Pro Ser Ile Leu Asp Cys Ser Ile Ile Arg Val Glu Tyr Ser 
        275                 280                 285             


Leu Met Val Tyr Val Asp Ile Pro Gly Ala Met Asp Leu Phe Leu Asn 
    290                 295                 300                 


Leu Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg 
305                 310                 315                 320 


Thr Ser Ser Val Ser Ser Gln Cys Ser Met Asn Met Asn Trp Leu Ser 
                325                 330                 335     


Leu Ser Leu Pro Glu Arg Pro Glu Ala Pro Pro Ser Tyr Ala Glu Val 
            340                 345                 350         


Val Thr Glu Glu Gln Arg Arg Asn Asn Leu Ala Pro Val Ser Ala Cys 
        355                 360                 365             


Asp Asp Phe Glu Arg Ala Leu Gln Gly Pro Leu Phe Ala Tyr Ile Gln 
    370                 375                 380                 


Glu Phe Arg Phe Leu Pro Pro Pro Leu Tyr Ser Glu Ile Asp Pro Asn 
385                 390                 395                 400 


Pro Asp Gln Ser Ala Asp Asp Arg Pro Ser Cys Pro Ser Arg 
                405                 410                 


<210>  13
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Cys Gly Arg Leu Gly Arg Phe Lys Ala Thr Leu Trp Leu Ser 
1               5                   10                  15      


Glu Glu His Pro Leu Ser Leu Gly Asp Gln Val Thr Pro Ile Ile Asp 
            20                  25                  30          


Leu Met Ala Ile Ser Asn Ala His Phe Ala Lys Leu Arg Asp Phe Ile 
        35                  40                  45              


Thr Leu Arg Leu Pro Pro Gly Phe Pro Val Lys Ile Glu Ile Pro Leu 
    50                  55                  60                  


Phe His Val Leu Asn Ala Arg Ile Thr Phe Ser Asn Leu Cys Gly Cys 
65                  70                  75                  80  


Asp Glu Pro Leu Ser Ser Val Trp Val Pro Ala Pro Ser Ser Ala Val 
                85                  90                  95      


Ala Ala Ser Gly Asn Pro Phe Pro Cys Glu Val Asp Pro Thr Val Phe 
            100                 105                 110         


Glu Val Pro Asn Gly Tyr Ser Val Leu Gly Met Glu Arg Asn Glu Pro 
        115                 120                 125             


Leu Arg Asp Glu Asp Asp Asp Leu Leu Gln Phe Ala Ile Gln Gln Ser 
    130                 135                 140                 


Leu Leu Glu Ala Gly Thr Glu Ala Glu Gln Val Thr Val Trp Glu Ala 
145                 150                 155                 160 


Leu Thr Asn Thr Arg Pro Gly Ala Arg Pro Pro Pro Gln Ala Thr Val 
                165                 170                 175     


Tyr Glu Glu Gln Leu Gln Leu Glu Arg Ala Leu Gln Glu Ser Leu Gln 
            180                 185                 190         


Leu Ser Thr Glu Pro Arg Gly Pro Gly Ser Pro Pro Arg Thr Pro Pro 
        195                 200                 205             


Ala Pro Gly Pro Pro Ser Phe Glu Glu Gln Leu Arg Leu Ala Leu Glu 
    210                 215                 220                 


Leu Ser Ser Arg Glu Gln Glu Glu Arg Glu Arg Arg Gly Gln Gln Glu 
225                 230                 235                 240 


Glu Glu Asp Leu Gln Arg Ile Leu Gln Leu Ser Leu Thr Glu His 
                245                 250                 255 


<210>  14
<211>  497
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Phe Asn Ser Phe Glu Gly Ser Lys Thr Cys Val Pro Ala Asp 
1               5                   10                  15      


Ile Asn Lys Glu Glu Glu Phe Val Glu Glu Phe Asn Arg Leu Lys Thr 
            20                  25                  30          


Phe Ala Asn Phe Pro Ser Gly Ser Pro Val Ser Ala Ser Thr Leu Ala 
        35                  40                  45              


Arg Ala Gly Phe Leu Tyr Thr Gly Glu Gly Asp Thr Val Arg Cys Phe 
    50                  55                  60                  


Ser Cys His Ala Ala Val Asp Arg Trp Gln Tyr Gly Asp Ser Ala Val 
65                  70                  75                  80  


Gly Arg His Arg Lys Val Ser Pro Asn Cys Arg Phe Ile Asn Gly Phe 
                85                  90                  95      


Tyr Leu Glu Asn Ser Ala Thr Gln Ser Thr Asn Ser Gly Ile Gln Asn 
            100                 105                 110         


Gly Gln Tyr Lys Val Glu Asn Tyr Leu Gly Ser Arg Asp His Phe Ala 
        115                 120                 125             


Leu Asp Arg Pro Ser Glu Thr His Ala Asp Tyr Leu Leu Arg Thr Gly 
    130                 135                 140                 


Gln Val Val Asp Ile Ser Asp Thr Ile Tyr Pro Arg Asn Pro Ala Met 
145                 150                 155                 160 


Tyr Ser Glu Glu Ala Arg Leu Lys Ser Phe Gln Asn Trp Pro Asp Tyr 
                165                 170                 175     


Ala His Leu Thr Pro Arg Glu Leu Ala Ser Ala Gly Leu Tyr Tyr Thr 
            180                 185                 190         


Gly Ile Gly Asp Gln Val Gln Cys Phe Cys Cys Gly Gly Lys Leu Lys 
        195                 200                 205             


Asn Trp Glu Pro Cys Asp Arg Ala Trp Ser Glu His Arg Arg His Phe 
    210                 215                 220                 


Pro Asn Cys Phe Phe Val Leu Gly Arg Asn Leu Asn Ile Arg Ser Glu 
225                 230                 235                 240 


Ser Asp Ala Val Ser Ser Asp Arg Asn Phe Pro Asn Ser Thr Asn Leu 
                245                 250                 255     


Pro Arg Asn Pro Ser Met Ala Asp Tyr Glu Ala Arg Ile Phe Thr Phe 
            260                 265                 270         


Gly Thr Trp Ile Tyr Ser Val Asn Lys Glu Gln Leu Ala Arg Ala Gly 
        275                 280                 285             


Phe Tyr Ala Leu Gly Glu Gly Asp Lys Val Lys Cys Phe His Cys Gly 
    290                 295                 300                 


Gly Gly Leu Thr Asp Trp Lys Pro Ser Glu Asp Pro Trp Glu Gln His 
305                 310                 315                 320 


Ala Lys Trp Tyr Pro Gly Cys Lys Tyr Leu Leu Glu Gln Lys Gly Gln 
                325                 330                 335     


Glu Tyr Ile Asn Asn Ile His Leu Thr His Ser Leu Glu Glu Cys Leu 
            340                 345                 350         


Val Arg Thr Thr Glu Lys Thr Pro Ser Leu Thr Arg Arg Ile Asp Asp 
        355                 360                 365             


Thr Ile Phe Gln Asn Pro Met Val Gln Glu Ala Ile Arg Met Gly Phe 
    370                 375                 380                 


Ser Phe Lys Asp Ile Lys Lys Ile Met Glu Glu Lys Ile Gln Ile Ser 
385                 390                 395                 400 


Gly Ser Asn Tyr Lys Ser Leu Glu Val Leu Val Ala Asp Leu Val Asn 
                405                 410                 415     


Ala Gln Lys Asp Ser Met Gln Asp Glu Ser Ser Gln Thr Ser Leu Gln 
            420                 425                 430         


Lys Glu Ile Ser Thr Glu Glu Gln Leu Arg Arg Leu Gln Glu Glu Lys 
        435                 440                 445             


Leu Cys Lys Ile Cys Met Asp Arg Asn Ile Ala Ile Val Phe Val Pro 
    450                 455                 460                 


Cys Gly His Leu Val Thr Cys Lys Gln Cys Ala Glu Ala Val Asp Lys 
465                 470                 475                 480 


Cys Pro Met Cys Tyr Thr Val Ile Thr Phe Lys Gln Lys Ile Phe Met 
                485                 490                 495     


Ser 
    


<210>  15
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Pro Lys Asp Ser Ala Lys Cys Leu His Arg Gly Pro Gln Pro 
1               5                   10                  15      


Ser His Trp Ala Ala Gly Asp Gly Pro Thr Gln Glu Arg Cys Gly Pro 
            20                  25                  30          


Arg Ser Leu Gly Ser Pro Val Leu Gly Leu Asp Thr Cys Arg Ala Trp 
        35                  40                  45              


Asp His Val Asp Gly Gln Ile Leu Gly Gln Leu Arg Pro Leu Thr Glu 
    50                  55                  60                  


Glu Glu Glu Glu Glu Gly Ala Gly Ala Thr Leu Ser Arg Gly Pro Ala 
65                  70                  75                  80  


Phe Pro Gly Met Gly Ser Glu Glu Leu Arg Leu Ala Ser Phe Tyr Asp 
                85                  90                  95      


Trp Pro Leu Thr Ala Glu Val Pro Pro Glu Leu Leu Ala Ala Ala Gly 
            100                 105                 110         


Phe Phe His Thr Gly His Gln Asp Lys Val Arg Cys Phe Phe Cys Tyr 
        115                 120                 125             


Gly Gly Leu Gln Ser Trp Lys Arg Gly Asp Asp Pro Trp Thr Glu His 
    130                 135                 140                 


Ala Lys Trp Phe Pro Ser Cys Gln Phe Leu Leu Arg Ser Lys Gly Arg 
145                 150                 155                 160 


Asp Phe Val His Ser Val Gln Glu Thr His Ser Gln Leu Leu Gly Ser 
                165                 170                 175     


Trp Asp Pro Trp Glu Glu Pro Glu Asp Ala Ala Pro Val Ala Pro Ser 
            180                 185                 190         


Val Pro Ala Ser Gly Tyr Pro Glu Leu Pro Thr Pro Arg Arg Glu Val 
        195                 200                 205             


Gln Ser Glu Ser Ala Gln Glu Pro Gly Gly Val Ser Pro Ala Glu Ala 
    210                 215                 220                 


Gln Arg Ala Trp Trp Val Leu Glu Pro Pro Gly Ala Arg Asp Val Glu 
225                 230                 235                 240 


Ala Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Leu 
                245                 250                 255     


Asp Arg Ala Val Ser Ile Val Phe Val Pro Cys Gly His Leu Val Cys 
            260                 265                 270         


Ala Glu Cys Ala Pro Gly Leu Gln Leu Cys Pro Ile Cys Arg Ala Pro 
        275                 280                 285             


Val Arg Ser Arg Val Arg Thr Phe Leu Ser 
    290                 295             


<210>  16
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Glu Ala Gly Phe Gln Ala Thr Asn Ala Phe Thr Glu Cys Lys 
1               5                   10                  15      


Phe Thr Cys Thr Ser Gly Lys Cys Leu Tyr Leu Gly Ser Leu Val Cys 
            20                  25                  30          


Asn Gln Gln Asn Asp Cys Gly Asp Asn Ser Asp Glu Glu Asn Cys Leu 
        35                  40                  45              


Leu Val Thr Glu His Pro Pro Pro Gly Ile Phe Asn Ser Glu Leu Glu 
    50                  55                  60                  


Phe Ala Gln Ile Ile Ile Ile Val Val Val Val Thr Val Met Val Val 
65                  70                  75                  80  


Val Ile Val Cys Leu Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe 
                85                  90                  95      


Ile Asn Arg Pro Asn Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln 
            100                 105                 110         


Glu Gly Cys Leu Trp Pro Ser Asp Ser Ala Ala Pro Arg Leu Gly Ala 
        115                 120                 125             


Ser Glu Ile Met His Ala Pro Arg Ser Arg Asp Arg Phe Thr Ala Pro 
    130                 135                 140                 


Ser Phe Ile Gln Arg Asp Arg Phe Ser Arg Phe Gln Pro Thr Tyr Pro 
145                 150                 155                 160 


Tyr Val Gln His Glu Ile Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp 
                165                 170                 175     


Gly Glu Glu Pro Pro Pro Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg 
            180                 185                 190         


Asp Pro Glu Gln Gln Met Glu Leu Asn Arg Glu Ser Val Arg Ala Pro 
        195                 200                 205             


Pro Asn Arg Thr Ile Phe Asp Ser Asp Leu Ile Asp Ile Ala Met Tyr 
    210                 215                 220                 


Ser Gly Gly Pro Cys Pro Pro Ser Ser Asn Ser Gly Ile Ser Ala Ser 
225                 230                 235                 240 


Thr Cys Ser Ser Asn Gly Arg Met Glu Gly Pro Pro Pro Thr Tyr Ser 
                245                 250                 255     


Glu Val Met Gly His His Pro Gly Ala Ser Phe Leu His His Gln Arg 
            260                 265                 270         


Ser Asn Ala His Arg Gly Ser Arg Leu Gln Phe Gln Gln Asn Asn Ala 
        275                 280                 285             


Glu Ser Thr Ile Val Pro Ile Lys Gly Lys Asp Arg Lys Pro Gly Asn 
    290                 295                 300                 


Leu Val 
305     


<210>  17
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gln Asn Arg Thr Gly Leu Ile Leu Cys Ala Leu Ala Leu Leu Met 
1               5                   10                  15      


Gly Phe Leu Met Val Cys Leu Gly Ala Phe Phe Ile Ser Trp Gly Ser 
            20                  25                  30          


Ile Phe Asp Cys Gln Gly Ser Leu Ile Ala Ala Tyr Leu Leu Leu Pro 
        35                  40                  45              


Leu Gly Phe Val Ile Leu Leu Ser Gly Ile Phe Trp Ser Asn Tyr Arg 
    50                  55                  60                  


Gln Val Thr Glu Ser Lys Gly Val Leu Arg His Met Leu Arg Gln His 
65                  70                  75                  80  


Leu Ala His Gly Ala Leu Pro Val Ala Thr Val Asp Arg Pro Asp Phe 
                85                  90                  95      


Tyr Pro Pro Ala Tyr Glu Glu Ser Leu Glu Val Glu Lys Gln Ser Cys 
            100                 105                 110         


Pro Ala Glu Arg Glu Ala Ser Gly Ile Pro Pro Pro Leu Tyr Thr Glu 
        115                 120                 125             


Thr Gly Leu Glu Phe Gln Asp Gly Asn Asp Ser His Pro Glu Ala Pro 
    130                 135                 140                 


Pro Ser Tyr Arg Glu Ser Ile Ala Gly Leu Val Val Thr Ala Ile Ser 
145                 150                 155                 160 


Glu Asp Ala Gln Arg Arg Gly Gln Glu Cys 
                165                 170 


<210>  18
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ser Leu Phe Arg Arg Ser Ser Ser Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Thr Ala Gly Ala Arg Gly Gly Gly Gly Gly Thr Ala Ala Pro Gln Glu 
            20                  25                  30          


Leu Asn Asn Ser Arg Pro Ala Arg Gln Val Arg Arg Leu Glu Phe Asn 
        35                  40                  45              


Gln Ala Met Asp Asp Phe Lys Thr Met Phe Pro Asn Met Asp Tyr Asp 
    50                  55                  60                  


Ile Ile Glu Cys Val Leu Arg Ala Asn Ser Gly Ala Val Asp Ala Thr 
65                  70                  75                  80  


Ile Asp Gln Leu Leu Gln Met Asn Leu Glu Gly Gly Gly Ser Ser Gly 
                85                  90                  95      


Gly Val Tyr Glu Asp Ser Ser Asp Ser Glu Asp Ser Ile Pro Pro Glu 
            100                 105                 110         


Ile Leu Glu Arg Thr Leu Glu Pro Asp Ser Ser Asp Glu Glu Pro Pro 
        115                 120                 125             


Pro Val Tyr Ser Pro Pro Ala Tyr His Met His Val Phe Asp Arg Pro 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Pro Thr Pro Pro Pro Arg Ile Asp Ala Leu Gly 
145                 150                 155                 160 


Ser Gly Ala Pro Thr Ser Gln Arg Arg Tyr Arg Asn Trp Asn Pro Pro 
                165                 170                 175     


Leu Leu Gly Asn Leu Pro Asp Asp Phe Leu Arg Ile Leu Pro Gln Gln 
            180                 185                 190         


Leu Asp Ser Ile Gln Gly Asn Ala Gly Gly Pro Lys Pro Gly Ser Gly 
        195                 200                 205             


Glu Gly Cys Pro Pro Ala Met Ala Gly Pro Gly Pro Gly Asp Gln Glu 
    210                 215                 220                 


Ser Arg Trp Lys Gln Tyr Leu Glu Asp Glu Arg Ile Ala Leu Phe Leu 
225                 230                 235                 240 


Gln Asn Glu Glu Phe Met Lys Glu Leu Gln Arg Asn Arg Asp Phe Leu 
                245                 250                 255     


Leu Ala Leu Glu Arg Asp Arg Leu Lys Tyr Glu Ser Gln Lys Ser Lys 
            260                 265                 270         


Ser Ser Ser Val Ala Val Gly Asn Asp Phe Gly Phe Ser Ser Pro Val 
        275                 280                 285             


Pro Gly Thr Gly Asp Ala Asn Pro Ala Val Ser Glu Asp Ala Leu Phe 
    290                 295                 300                 


Arg Asp Lys Leu Lys His Met Gly Lys Ser Thr Arg Arg Lys Leu Phe 
305                 310                 315                 320 


Glu Leu Ala Arg Ala Phe Ser Glu Lys Thr Lys Met Arg Lys Ser Lys 
                325                 330                 335     


Arg Lys His Leu Leu Lys His Gln Ser Leu Gly Ala Ala Ala Ser Thr 
            340                 345                 350         


Ala Asn Leu Leu Asp Asp Val Glu Gly His Ala Cys Asp Glu Asp Phe 
        355                 360                 365             


Arg Gly Arg Arg Gln Glu Ala Pro Lys Val Glu Glu Gly Leu Arg Glu 
    370                 375                 380                 


Gly Gln 
385     


<210>  19
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Asn Ser Lys Gly Gln Tyr Pro Thr Gln Pro Thr Tyr Pro Val Gln 
1               5                   10                  15      


Pro Pro Gly Asn Pro Val Tyr Pro Gln Thr Leu His Leu Pro Gln Ala 
            20                  25                  30          


Pro Pro Tyr Thr Asp Ala Pro Pro Ala Tyr Ser Glu Leu Tyr Arg Pro 
        35                  40                  45              


Ser Phe Val His Pro Gly Ala Ala Thr Val Pro Thr Met Ser Ala Ala 
    50                  55                  60                  


Phe Pro Gly Ala Ser Leu Tyr Leu Pro Met Ala Gln Ser Val Ala Val 
65                  70                  75                  80  


Gly Pro Leu Gly Ser Thr Ile Pro Met Ala Tyr Tyr Pro Val Gly Pro 
                85                  90                  95      


Ile Tyr Pro Pro Gly Ser Thr Val Leu Val Glu Gly Gly Tyr Asp Ala 
            100                 105                 110         


Gly Ala Arg Phe Gly Ala Gly Ala Thr Ala Gly Asn Ile Pro Pro Pro 
        115                 120                 125             


Pro Pro Gly Cys Pro Pro Asn Ala Ala Gln Leu Ala Val Met Gln Gly 
    130                 135                 140                 


Ala Asn Val Leu Val Thr Gln Arg Lys Gly Asn Phe Phe Met Gly Gly 
145                 150                 155                 160 


Ser Asp Gly Gly Tyr Thr Ile Trp 
                165             


<210>  20
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Ile Thr Val Tyr Cys Val Arg Arg Asp Leu Ser Glu Val Thr 
1               5                   10                  15      


Phe Ser Leu Gln Val Ser Pro Asp Phe Glu Leu Arg Asn Phe Lys Val 
            20                  25                  30          


Leu Cys Glu Ala Glu Ser Arg Val Pro Val Glu Glu Ile Gln Ile Ile 
        35                  40                  45              


His Met Glu Arg Leu Leu Ile Glu Asp His Cys Ser Leu Gly Ser Tyr 
    50                  55                  60                  


Gly Leu Lys Asp Gly Asp Ile Val Val Leu Leu Gln Lys Asp Asn Val 
65                  70                  75                  80  


Gly Pro Arg Ala Pro Gly Arg Ala Pro Asn Gln Pro Arg Val Asp Phe 
                85                  90                  95      


Ser Gly Ile Ala Val Pro Gly Thr Ser Ser Ser Arg Pro Gln His Pro 
            100                 105                 110         


Gly Gln Gln Gln Gln Arg Thr Pro Ala Ala Gln Arg Ser Gln Gly Leu 
        115                 120                 125             


Ala Ser Gly Glu Lys Val Ala Gly Leu Gln Gly Leu Gly Ser Pro Ala 
    130                 135                 140                 


Leu Ile Arg Ser Met Leu Leu Ser Asn Pro His Asp Leu Ser Leu Leu 
145                 150                 155                 160 


Lys Glu Arg Asn Pro Pro Leu Ala Glu Ala Leu Leu Ser Gly Ser Leu 
                165                 170                 175     


Glu Thr Phe Ser Gln Val Leu Met Glu Gln Gln Arg Glu Lys Ala Leu 
            180                 185                 190         


Arg Glu Gln Glu Arg Leu Arg Leu Tyr Thr Ala Asp Pro Leu Asp Arg 
        195                 200                 205             


Glu Ala Gln Ala Lys Ile Glu Glu Glu Ile Arg Gln Gln Asn Ile Glu 
    210                 215                 220                 


Glu Asn Met Asn Ile Ala Ile Glu Glu Ala Pro Glu Ser Phe Gly Gln 
225                 230                 235                 240 


Val Thr Met Leu Tyr Ile Asn Cys Lys Val Asn Gly His Pro Leu Lys 
                245                 250                 255     


Ala Phe Val Asp Ser Gly Ala Gln Met Thr Ile Met Ser Gln Ala Cys 
            260                 265                 270         


Ala Glu Arg Cys Asn Ile Met Arg Leu Val Asp Arg Arg Trp Ala Gly 
        275                 280                 285             


Val Ala Lys Gly Val Gly Thr Gln Arg Ile Ile Gly Arg Val His Leu 
    290                 295                 300                 


Ala Gln Ile Gln Ile Glu Gly Asp Phe Leu Gln Cys Ser Phe Ser Ile 
305                 310                 315                 320 


Leu Glu Asp Gln Pro Met Asp Met Leu Leu Gly Leu Asp Met Leu Arg 
                325                 330                 335     


Arg His Gln Cys Ser Ile Asp Leu Lys Lys Asn Val Leu Val Ile Gly 
            340                 345                 350         


Thr Thr Gly Thr Gln Thr Tyr Phe Leu Pro Glu Gly Glu Leu Pro Leu 
        355                 360                 365             


Cys Ser Arg Met Val Ser Gly Gln Asp Glu Ser Ser Asp Lys Glu Ile 
    370                 375                 380                 


Thr His Ser Val Met Asp Ser Gly Arg Lys Glu His 
385                 390                 395     


<210>  21
<211>  650
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Glu Gly Thr Ala Glu Ala Pro Leu Glu Asn Gly Gly Gly Gly 
1               5                   10                  15      


Asp Ser Gly Ala Gly Ala Leu Glu Arg Gly Val Ala Pro Ile Lys Arg 
            20                  25                  30          


Gln Tyr Leu Thr Thr Lys Glu Gln Phe His Gln Phe Leu Glu Ala Lys 
        35                  40                  45              


Gly Gln Glu Lys Thr Cys Arg Glu Thr Glu Val Gly Asp Pro Ala Gly 
    50                  55                  60                  


Asn Glu Leu Ala Glu Pro Glu Ala Lys Arg Ile Arg Leu Glu Asp Gly 
65                  70                  75                  80  


Gln Thr Ala Asp Gly Gln Thr Glu Glu Ala Ala Glu Pro Gly Glu Gln 
                85                  90                  95      


Leu Gln Thr Gln Lys Arg Ala Arg Gly Gln Asn Lys Gly Arg Pro His 
            100                 105                 110         


Val Lys Pro Thr Asn Tyr Asp Lys Asn Arg Leu Cys Pro Ser Leu Ile 
        115                 120                 125             


Gln Glu Ser Ala Ala Lys Cys Phe Phe Gly Asp Arg Cys Arg Phe Leu 
    130                 135                 140                 


His Asp Val Gly Arg Tyr Leu Glu Thr Lys Pro Ala Asp Leu Gly Pro 
145                 150                 155                 160 


Arg Cys Val Leu Phe Glu Thr Phe Gly Arg Cys Pro Tyr Gly Val Thr 
                165                 170                 175     


Cys Arg Phe Ala Gly Ala His Leu Gly Pro Glu Gly Gln Asn Leu Val 
            180                 185                 190         


Gln Glu Glu Leu Ala Ala Arg Gly Thr Gln Pro Pro Ser Ile Arg Asn 
        195                 200                 205             


Gly Leu Asp Lys Ala Leu Gln Gln Gln Leu Arg Lys Arg Glu Val Arg 
    210                 215                 220                 


Phe Glu Arg Ala Glu Gln Ala Leu Arg Arg Phe Ser Gln Gly Pro Thr 
225                 230                 235                 240 


Pro Ala Ala Ala Val Pro Glu Gly Thr Ala Ala Glu Gly Ala Pro Arg 
                245                 250                 255     


Gln Glu Asn Cys Gly Ala Gln Gln Val Pro Ala Gly Pro Gly Thr Ser 
            260                 265                 270         


Thr Pro Pro Ser Ser Pro Val Arg Thr Cys Gly Pro Leu Thr Asp Glu 
        275                 280                 285             


Asp Val Val Arg Leu Arg Pro Cys Glu Lys Lys Arg Leu Asp Ile Arg 
    290                 295                 300                 


Gly Lys Leu Tyr Leu Ala Pro Leu Thr Thr Cys Gly Asn Leu Pro Phe 
305                 310                 315                 320 


Arg Arg Ile Cys Lys Arg Phe Gly Ala Asp Val Thr Cys Gly Glu Met 
                325                 330                 335     


Ala Val Cys Thr Asn Leu Leu Gln Gly Gln Met Ser Glu Trp Ala Leu 
            340                 345                 350         


Leu Lys Arg His Gln Cys Glu Asp Ile Phe Gly Val Gln Leu Glu Gly 
        355                 360                 365             


Ala Phe Pro Asp Thr Met Thr Lys Cys Ala Glu Leu Leu Ser Arg Thr 
    370                 375                 380                 


Val Glu Val Asp Phe Val Asp Ile Asn Val Gly Cys Pro Ile Asp Leu 
385                 390                 395                 400 


Val Tyr Lys Lys Gly Gly Gly Cys Ala Leu Met Asn Arg Ser Thr Lys 
                405                 410                 415     


Phe Gln Gln Ile Val Arg Gly Met Asn Gln Val Leu Asp Val Pro Leu 
            420                 425                 430         


Thr Val Lys Ile Arg Thr Gly Val Gln Glu Arg Val Asn Leu Ala His 
        435                 440                 445             


Arg Leu Leu Pro Glu Leu Arg Asp Trp Gly Val Ala Leu Val Thr Leu 
    450                 455                 460                 


His Gly Arg Ser Arg Glu Gln Arg Tyr Thr Lys Leu Ala Asp Trp Gln 
465                 470                 475                 480 


Tyr Ile Glu Glu Cys Val Gln Ala Ala Ser Pro Met Pro Leu Phe Gly 
                485                 490                 495     


Asn Gly Asp Ile Leu Ser Phe Glu Asp Ala Asn Arg Ala Met Gln Thr 
            500                 505                 510         


Gly Val Thr Gly Ile Met Ile Ala Arg Gly Ala Leu Leu Lys Pro Trp 
        515                 520                 525             


Leu Phe Thr Glu Ile Lys Glu Gln Arg His Trp Asp Ile Ser Ser Ser 
    530                 535                 540                 


Glu Arg Leu Asp Ile Leu Arg Asp Phe Thr Asn Tyr Gly Leu Glu His 
545                 550                 555                 560 


Trp Gly Ser Asp Thr Gln Gly Val Glu Lys Thr Arg Arg Phe Leu Leu 
                565                 570                 575     


Glu Trp Leu Ser Phe Leu Cys Arg Tyr Val Pro Val Gly Leu Leu Glu 
            580                 585                 590         


Arg Leu Pro Gln Arg Ile Asn Glu Arg Pro Pro Tyr Tyr Leu Gly Arg 
        595                 600                 605             


Asp Tyr Leu Glu Thr Leu Met Ala Ser Gln Lys Ala Ala Asp Trp Ile 
    610                 615                 620                 


Arg Ile Ser Glu Met Leu Leu Gly Pro Val Pro Pro Ser Phe Ala Phe 
625                 630                 635                 640 


Leu Pro Lys His Lys Ala Asn Ala Tyr Lys 
                645                 650 


<210>  22
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gln Pro Pro Val Pro Gly Pro Leu Gly Leu Leu Asp Pro Ala Glu 
1               5                   10                  15      


Gly Leu Ser Arg Arg Lys Lys Thr Ser Leu Trp Phe Val Gly Ser Leu 
            20                  25                  30          


Leu Leu Val Ser Val Leu Ile Val Thr Val Gly Leu Ala Ala Thr Thr 
        35                  40                  45              


Arg Thr Glu Asn Val Thr Val Gly Gly Tyr Tyr Pro Gly Ile Ile Leu 
    50                  55                  60                  


Gly Phe Gly Ser Phe Leu Gly Ile Ile Gly Ile Asn Leu Val Glu Asn 
65                  70                  75                  80  


Arg Arg Gln Met Leu Val Ala Ala Ile Val Phe Ile Ser Phe Gly Val 
                85                  90                  95      


Val Ala Ala Phe Cys Cys Ala Ile Val Asp Gly Val Phe Ala Ala Gln 
            100                 105                 110         


His Ile Glu Pro Arg Pro Leu Thr Thr Gly Arg Cys Gln Phe Tyr Ser 
        115                 120                 125             


Ser Gly Val Gly Tyr Leu Tyr Asp Val Tyr Gln Thr Glu Val Thr Cys 
    130                 135                 140                 


His Ser Leu Asp Gly Lys Cys Gln Leu Lys Val Arg Ser Asn Thr Cys 
145                 150                 155                 160 


Tyr Cys Cys Asp Leu Tyr Ala Cys Gly Ser Ala Glu Pro Ser Pro Ala 
                165                 170                 175     


Tyr Tyr Glu Phe Ile Gly Val Ser Gly Cys Gln Asp Val Leu His Leu 
            180                 185                 190         


Tyr Arg Leu Leu Trp Ala Ser Ala Val Leu Asn Val Leu Gly Leu Phe 
        195                 200                 205             


Leu Gly Ile Ile Thr Ala Ala Val Leu Gly Ala Phe Lys Asp Met Val 
    210                 215                 220                 


Pro Leu Ser Gln Leu Ala Tyr Gly Pro Ala Val Pro Pro Gln Thr Leu 
225                 230                 235                 240 


Tyr Asn Pro Ala Gln Gln Ile Leu Ala Tyr Ala Gly Phe Arg Leu Thr 
                245                 250                 255     


Pro Glu Pro Val Pro Thr Cys Ser Ser Tyr Pro Leu Pro Leu Gln Pro 
            260                 265                 270         


Cys Ser Arg Phe Pro Val Ala Pro Ser Ser Ala Leu Ala Ser Ser Glu 
        275                 280                 285             


Asp Leu Gln Pro Pro Ser Pro Ser Ser Ser Gly Ser Gly Leu Pro Gly 
    290                 295                 300                 


Gln Ala Pro Pro Cys Tyr Ala Pro Thr Tyr Phe Pro Pro Gly Glu Lys 
305                 310                 315                 320 


Pro Pro Pro Tyr Ala Pro 
                325     


<210>  23
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Phe Gly Leu Ser Trp Val Leu Leu Val Val Phe Leu Gln Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Asp Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Val 
        35                  40                  45              


Ser Asp His Tyr Val Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Pro 
    50                  55                  60                  


Glu Trp Val Gly Cys Phe Arg Ser Lys Ala His Lys Ser Thr Thr Glu 
65                  70                  75                  80  


Tyr Ala Ala Ser Val Lys Gly Arg Phe Thr Ile Leu Arg Asp Asp Ser 
                85                  90                  95      


Lys Asn Ser Val His Leu Gln Met Asn Ser Leu Lys Thr Asp Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Val Arg Asp Leu Glu Gly Ala Gly Lys Tyr Asp 
        115                 120                 125             


Trp Tyr Phe Asp Ile Trp Gly Arg Gly Ile Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
                245                 250                 255     


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
            260                 265                 270         


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
        275                 280                 285             


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    290                 295                 300                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            420                 425                 430         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        515                 520     


<210>  24
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Cys His Gly Arg Ile Ala Pro Lys Ser Thr Ser Val Phe Ala Val 
1               5                   10                  15      


Ala Ser Val Gly His Gly Val Phe Leu Pro Leu Val Ile Leu Cys Thr 
            20                  25                  30          


Leu Leu Gly Asp Gly Leu Ala Ser Val Cys Pro Leu Pro Pro Glu Pro 
        35                  40                  45              


Glu Asn Gly Gly Tyr Ile Cys His Pro Arg Pro Cys Arg Asp Pro Leu 
    50                  55                  60                  


Thr Ala Gly Ser Val Ile Glu Tyr Leu Cys Ala Glu Gly Tyr Met Leu 
65                  70                  75                  80  


Lys Gly Asp Tyr Lys Tyr Leu Thr Cys Lys Asn Gly Glu Trp Lys Pro 
                85                  90                  95      


Ala Met Glu Ile Ser Cys Arg Leu Asn Glu Asp Lys Asp Thr His Thr 
            100                 105                 110         


Ser Leu Gly Val Pro Thr Leu Ser Ile Val Ala Ser Thr Ala Ser Ser 
        115                 120                 125             


Val Ala Leu Ile Leu Leu Leu Val Val Leu Phe Val Leu Leu Gln Pro 
    130                 135                 140                 


Lys Leu Lys Ser Phe His His Ser Arg Arg Asp Gln Gly Val Ser Gly 
145                 150                 155                 160 


Asp Gln Val Ser Ile Met Val Asp Gly Val Gln Val Ala Leu Pro Ser 
                165                 170                 175     


Tyr Glu Glu Ala Val Tyr Gly Ser Ser Gly His Cys Val Pro Pro Ala 
            180                 185                 190         


Asp Pro Arg Val Gln Ile Val Leu Ser Glu Gly Ser Gly Pro Ser Gly 
        195                 200                 205             


Arg Ser Val Pro Arg Glu Gln Gln Leu Pro Asp Gln Gly Ala Cys Ser 
    210                 215                 220                 


Ser Ala Gly Gly Glu Asp Glu Ala Pro Gly Gln Ser Gly Leu Cys Glu 
225                 230                 235                 240 


Ala Trp Gly Ser Arg Ala Ser Glu Thr Val Met Val His Gln Ala Thr 
                245                 250                 255     


Thr Ser Ser Trp Val Ala Gly Ser Gly Asn Arg Gln Leu Ala His Lys 
            260                 265                 270         


Glu Thr Ala Asp Ser Glu Asn Ser Asp Ile Gln Ser Leu Leu Ser Leu 
        275                 280                 285             


Thr Ser Glu Glu Tyr Thr Asp Asp Ile Pro Leu Leu Lys Glu Ala 
    290                 295                 300             


<210>  25
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Asp Pro Arg Leu Ser Thr Val Arg Gln Thr Cys Cys Cys Phe Asn 
1               5                   10                  15      


Val Arg Ile Ala Thr Thr Ala Leu Ala Ile Tyr His Val Ile Met Ser 
            20                  25                  30          


Val Leu Leu Phe Ile Glu His Ser Val Glu Val Ala His Gly Lys Ala 
        35                  40                  45              


Ser Cys Lys Leu Ser Gln Met Gly Tyr Leu Arg Ile Ala Asp Leu Ile 
    50                  55                  60                  


Ser Ser Phe Leu Leu Ile Thr Met Leu Phe Ile Ile Ser Leu Ser Leu 
65                  70                  75                  80  


Leu Ile Gly Val Val Lys Asn Arg Glu Lys Tyr Leu Leu Pro Phe Leu 
                85                  90                  95      


Ser Leu Gln Ile Met Asp Tyr Leu Leu Cys Leu Leu Thr Leu Leu Gly 
            100                 105                 110         


Ser Tyr Ile Glu Leu Pro Ala Tyr Leu Lys Leu Ala Ser Arg Ser Arg 
        115                 120                 125             


Ala Ser Ser Ser Lys Phe Pro Leu Met Thr Leu Gln Leu Leu Asp Phe 
    130                 135                 140                 


Cys Leu Ser Ile Leu Thr Leu Cys Ser Ser Tyr Met Glu Val Pro Thr 
145                 150                 155                 160 


Tyr Leu Asn Phe Lys Ser Met Asn His Met Asn Tyr Leu Pro Ser Gln 
                165                 170                 175     


Glu Asp Met Pro His Asn Gln Phe Ile Lys Met Met Ile Ile Phe Ser 
            180                 185                 190         


Ile Ala Phe Ile Thr Val Leu Ile Phe Lys Val Tyr Met Phe Lys Cys 
        195                 200                 205             


Val Trp Arg Cys Tyr Arg Leu Ile Lys Cys Met Asn Ser Val Glu Glu 
    210                 215                 220                 


Lys Arg Asn Ser Lys Met Leu Gln Lys Val Val Leu Pro Ser Tyr Glu 
225                 230                 235                 240 


Glu Ala Leu Ser Leu Pro Ser Lys Thr Pro Glu Gly Gly Pro Ala Pro 
                245                 250                 255     


Pro Pro Tyr Ser Glu Val 
            260         


<210>  26
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ser Ser Asp His Leu Asn Asn Ser Thr Leu Lys Glu Ala Gln Phe 
1               5                   10                  15      


Lys Asp Leu Phe Leu Lys Lys Ala Glu Leu Glu Phe Ala Gln Ile Ile 
            20                  25                  30          


Ile Ile Val Val Val Val Thr Val Met Val Val Val Ile Val Cys Leu 
        35                  40                  45              


Leu Asn His Tyr Lys Val Ser Thr Arg Ser Phe Ile Asn Arg Pro Asn 
    50                  55                  60                  


Gln Ser Arg Arg Arg Glu Asp Gly Leu Pro Gln Ile Met His Ala Pro 
65                  70                  75                  80  


Arg Ser Arg Asp Arg Phe Thr Ala Pro Ser Phe Ile Gln Arg Asp Arg 
                85                  90                  95      


Phe Ser Arg Phe Gln Pro Thr Tyr Pro Tyr Val Gln His Glu Ile Asp 
            100                 105                 110         


Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr 
        115                 120                 125             


Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Met Glu 
    130                 135                 140                 


Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp 
145                 150                 155                 160 


Ser Asp Leu Ile Asp Ile Ala Met Tyr Ser Gly Gly Pro Cys Pro Pro 
                165                 170                 175     


Ser Ser Asn Ser Gly Ile Ser Ala Ser Thr Cys Ser Ser Asn Gly Arg 
            180                 185                 190         


Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Met Gly His His Pro 
        195                 200                 205             


Gly Ala Ser Phe Leu His His Gln Arg Ser Asn Ala His Arg Gly Ser 
    210                 215                 220                 


Arg Leu Gln Phe Gln Gln Asn Asn Ala Glu Ser Thr Ile Val Pro Ile 
225                 230                 235                 240 


Lys Gly Lys Asp Arg Lys Pro Gly Asn Leu Val 
                245                 250     


<210>  27
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Val Pro Gly Pro Tyr Gln Ala Ala Thr Gly Pro Ser Ser Ala 
1               5                   10                  15      


Pro Ser Ala Pro Pro Ser Tyr Glu Glu Thr Val Ala Val Asn Ser Tyr 
            20                  25                  30          


Tyr Pro Thr Pro Pro Ala Pro Met Pro Gly Pro Thr Thr Gly Leu Val 
        35                  40                  45              


Thr Gly Pro Asp Gly Lys Gly Met Asn Pro Pro Ser Tyr Tyr Thr Gln 
    50                  55                  60                  


Pro Ala Pro Ile Pro Asn Asn Asn Pro Ile Thr Val Gln Thr Val Tyr 
65                  70                  75                  80  


Val Gln His Pro Ile Thr Phe Leu Asp Arg Pro Ile Gln Met Cys Cys 
                85                  90                  95      


Pro Ser Cys Asn Lys Met Ile Val Ser Gln Leu Ser Tyr Asn Ala Gly 
            100                 105                 110         


Ala Leu Thr Trp Leu Ser Cys Gly Ser Leu Cys Leu Leu Gly Cys Ile 
        115                 120                 125             


Ala Gly Cys Cys Phe Ile Pro Phe Cys Val Asp Ala Leu Gln Asp Val 
    130                 135                 140                 


Asp His Tyr Cys Pro Asn Cys Arg Ala Leu Leu Gly Thr Tyr Lys Arg 
145                 150                 155                 160 


Leu 
    


<210>  28
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Pro Arg Glu Asp Ala His Phe Ile Tyr Gly Tyr Pro Lys Lys Gly 
1               5                   10                  15      


His Gly His Ser Tyr Thr Thr Ala Glu Glu Ala Ala Gly Ile Gly Ile 
            20                  25                  30          


Leu Thr Val Ile Leu Gly Val Leu Leu Leu Ile Gly Cys Trp Tyr Cys 
        35                  40                  45              


Arg Arg Arg Asn Gly Tyr Arg Ala Leu Met Asp Lys Ser Leu His Val 
    50                  55                  60                  


Gly Thr Gln Cys Ala Leu Thr Arg Arg Cys Pro Gln Glu Gly Phe Asp 
65                  70                  75                  80  


His Arg Asp Ser Lys Val Ser Leu Gln Glu Lys Asn Cys Glu Pro Val 
                85                  90                  95      


Val Pro Asn Ala Pro Pro Ala Tyr Glu Lys Leu Ser Ala Glu Gln Ser 
            100                 105                 110         


Pro Pro Pro Tyr Ser Pro 
        115             


<210>  29
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Asp His His Gln Pro Gly Thr Gly Arg Tyr Gln Val Leu Leu Asn 
1               5                   10                  15      


Glu Glu Asp Asn Ser Glu Ser Ser Ala Ile Glu Gln Pro Pro Thr Ser 
            20                  25                  30          


Asn Pro Ala Pro Gln Ile Val Gln Ala Ala Ser Ser Ala Pro Ala Leu 
        35                  40                  45              


Glu Thr Asp Ser Ser Pro Pro Pro Tyr Ser Ser Ile Thr Val Glu Val 
    50                  55                  60                  


Pro Thr Thr Ser Asp Thr Glu Val Tyr Gly Glu Phe Tyr Pro Val Pro 
65                  70                  75                  80  


Pro Pro Tyr Ser Val Ala Thr Ser Leu Pro Thr Tyr Asp Glu Ala Glu 
                85                  90                  95      


Lys Ala Lys Ala Ala Ala Met Ala Ala Ala Ala Ala Glu Thr Ser Gln 
            100                 105                 110         


Arg Ile Gln Glu Glu Glu Cys Pro Pro Arg Asp Asp Phe Ser Asp Ala 
        115                 120                 125             


Asp Gln Leu Arg Val Gly Asn Asp Gly Ile Phe Met Leu Ala Phe Phe 
    130                 135                 140                 


Met Ala Phe Ile Phe Asn Trp Leu Gly Phe Cys Leu Ser Phe Cys Ile 
145                 150                 155                 160 


Thr Asn Thr Ile Ala Gly Arg Tyr Gly Ala Ile Cys Gly Phe Gly Leu 
                165                 170                 175     


Ser Leu Ile Lys Trp Ile Leu Ile Val Arg Phe Ser Asp Tyr Phe Thr 
            180                 185                 190         


Gly Tyr Phe Asn Gly Gln Tyr Trp Leu Trp Trp Ile Phe Leu Val Leu 
        195                 200                 205             


Gly Leu Leu Leu Phe Phe Arg Gly Phe Val Asn Tyr Leu Lys Val Arg 
    210                 215                 220                 


Asn Met Ser Glu Ser Met Ala Ala Ala His Arg Thr Arg Tyr Phe Phe 
225                 230                 235                 240 


Leu Leu 
        


<210>  30
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val Val Val Met 
1               5                   10                  15      


Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His Tyr Lys Leu 
            20                  25                  30          


Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg Arg Arg Glu 
        35                  40                  45              


Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu Ser Thr Val 
    50                  55                  60                  


Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro Pro Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu Arg Phe His 
                85                  90                  95      


Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile Asp Leu Pro 
            100                 105                 110         


Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro Tyr Gln Gly 
        115                 120                 125             


Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu Glu Leu Asn 
    130                 135                 140                 


Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe Asp Ser Asp 
145                 150                 155                 160 


Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro Ser Ser Asn 
                165                 170                 175     


Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg Met Glu Gly 
            180                 185                 190         


Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro Gly Ser Ser 
        195                 200                 205             


Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu Glu Gly Thr 
    210                 215                 220                 


Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala Ala Ile Trp 
225                 230                 235                 240 


Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
                245                 250         


<210>  31
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Val Leu Glu Ser Thr Met Val Cys Val Asp Asn Ser Glu Tyr Met 
1               5                   10                  15      


Arg Asn Gly Asp Phe Leu Pro Thr Arg Leu Gln Ala Gln Gln Asp Ala 
            20                  25                  30          


Val Asn Ile Val Cys His Ser Lys Thr Arg Ser Asn Pro Glu Asn Asn 
        35                  40                  45              


Val Gly Leu Ile Thr Leu Ala Asn Asp Cys Glu Val Leu Thr Thr Leu 
    50                  55                  60                  


Thr Pro Asp Thr Gly Arg Ile Leu Ser Lys Leu His Thr Val Gln Pro 
65                  70                  75                  80  


Lys Gly Lys Ile Thr Phe Cys Thr Gly Ile Arg Val Ala His Leu Ala 
                85                  90                  95      


Leu Lys His Arg Gln Gly Lys Asn His Lys Met Arg Ile Ile Ala Phe 
            100                 105                 110         


Val Gly Ser Pro Val Glu Asp Asn Glu Lys Asp Leu Val Lys Leu Ala 
        115                 120                 125             


Lys Arg Leu Lys Lys Glu Lys Val Asn Val Asp Ile Ile Asn Phe Gly 
    130                 135                 140                 


Glu Glu Glu Val Asn Thr Glu Lys Leu Thr Ala Phe Val Asn Thr Leu 
145                 150                 155                 160 


Asn Gly Lys Asp Gly Thr Gly Ser His Leu Val Thr Val Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Asp Ala Leu Ile Ser Ser Pro Ile Leu Ala Gly Glu 
            180                 185                 190         


Gly Gly Ala Met Leu Gly Leu Gly Ala Ser Asp Phe Glu Phe Gly Val 
        195                 200                 205             


Asp Pro Ser Ala Asp Pro Glu Leu Ala Leu Ala Leu Arg Val Ser Met 
    210                 215                 220                 


Glu Glu Gln Arg Gln Arg Gln Glu Glu Glu Ala Arg Arg Ala Ala Ala 
225                 230                 235                 240 


Ala Ser Ala Ala Glu Ala Gly Ile Ala Thr Thr Gly Thr Glu Asp Ser 
                245                 250                 255     


Asp Asp Ala Leu Leu Lys Met Thr Ile Ser Gln Gln Glu Phe Gly Arg 
            260                 265                 270         


Thr Gly Leu Pro Asp Leu Ser Ser Met Thr Glu Glu Glu Gln Ile Ala 
        275                 280                 285             


Tyr Ala Met Gln Met Ser Leu Gln Gly Ala Glu Phe Gly Gln Ala Glu 
    290                 295                 300                 


Ser Ala Asp Ile Asp Ala Ser Ser Ala Met Asp Thr Ser Glu Pro Ala 
305                 310                 315                 320 


Lys Glu Glu Asp Asp Tyr Asp Val Met Gln Asp Pro Glu Phe Leu Gln 
                325                 330                 335     


Ser Val Leu Glu Asn Leu Pro Gly Val Asp Pro Asn Asn Glu Ala Ile 
            340                 345                 350         


Arg Asn Ala Met Gly Ser Leu Ala Ser Gln Ala Thr Lys Asp Gly Lys 
        355                 360                 365             


Lys Asp Lys Lys Glu Glu Asp Lys Lys 
    370                 375         


<210>  32
<211>  621
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Asp Phe Glu Glu Leu Arg Asn Met Val Ser Ser Phe Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Phe Ala Gly Arg Asn Lys Ser Gly 
            20                  25                  30          


Arg Lys His Asp Leu Leu Met Arg Ala Leu His Leu Leu Lys Ser Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Ile Lys Ile Arg Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Tyr Pro Arg Thr Leu Glu Gly Leu Ser Asp Leu Ser Thr Ile Lys Ser 
65                  70                  75                  80  


Ser Val Phe Ser Leu Asp Gly Gly Ser Ser Pro Val Glu Pro Asp Leu 
                85                  90                  95      


Ala Val Ala Gly Ile His Ser Leu Pro Ser Thr Ser Val Thr Pro His 
            100                 105                 110         


Ser Pro Ser Ser Pro Val Gly Ser Val Leu Leu Gln Asp Thr Lys Pro 
        115                 120                 125             


Thr Phe Glu Met Gln Gln Pro Ser Pro Pro Ile Pro Pro Val His Pro 
    130                 135                 140                 


Asp Val Gln Leu Lys Asn Leu Pro Phe Tyr Asp Val Leu Asp Val Leu 
145                 150                 155                 160 


Ile Lys Pro Thr Ser Leu Val Gln Ser Ser Ile Gln Arg Phe Gln Glu 
                165                 170                 175     


Lys Phe Phe Ile Phe Ala Leu Thr Pro Gln Gln Val Arg Glu Ile Cys 
            180                 185                 190         


Ile Ser Arg Asp Phe Leu Pro Gly Gly Arg Arg Asp Tyr Thr Val Gln 
        195                 200                 205             


Val Gln Leu Arg Leu Cys Leu Ala Glu Thr Ser Cys Pro Gln Glu Asp 
    210                 215                 220                 


Asn Tyr Pro Asn Ser Leu Cys Ile Lys Val Asn Gly Lys Leu Phe Pro 
225                 230                 235                 240 


Leu Pro Gly Tyr Ala Pro Pro Pro Lys Asn Gly Ile Glu Gln Lys Arg 
                245                 250                 255     


Pro Gly Arg Pro Leu Asn Ile Thr Ser Leu Val Arg Leu Ser Ser Ala 
            260                 265                 270         


Val Pro Asn Gln Ile Ser Ile Ser Trp Ala Ser Glu Ile Gly Lys Asn 
        275                 280                 285             


Tyr Ser Met Ser Val Tyr Leu Val Arg Gln Leu Thr Ser Ala Met Leu 
    290                 295                 300                 


Leu Gln Arg Leu Lys Met Lys Gly Ile Arg Asn Pro Asp His Ser Arg 
305                 310                 315                 320 


Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro Asp Ser Glu Ile Ala 
                325                 330                 335     


Thr Thr Ser Leu Arg Val Ser Leu Met Cys Pro Leu Gly Lys Met Arg 
            340                 345                 350         


Leu Thr Ile Pro Cys Arg Ala Val Thr Cys Thr His Leu Gln Cys Phe 
        355                 360                 365             


Asp Ala Ala Leu Tyr Leu Gln Met Asn Glu Lys Lys Pro Thr Trp Ile 
    370                 375                 380                 


Cys Pro Val Cys Asp Lys Lys Ala Ala Tyr Glu Ser Leu Ile Leu Asp 
385                 390                 395                 400 


Gly Leu Phe Met Glu Ile Leu Asn Asp Cys Ser Asp Val Asp Glu Ile 
                405                 410                 415     


Lys Phe Gln Glu Asp Gly Ser Trp Cys Pro Met Arg Pro Lys Lys Glu 
            420                 425                 430         


Ala Met Lys Val Ser Ser Gln Pro Cys Thr Lys Ile Glu Ser Ser Ser 
        435                 440                 445             


Val Leu Ser Lys Pro Cys Ser Val Thr Val Ala Ser Glu Ala Ser Lys 
    450                 455                 460                 


Lys Lys Val Asp Val Ile Asp Leu Thr Ile Glu Ser Ser Ser Asp Glu 
465                 470                 475                 480 


Glu Glu Asp Pro Pro Ala Lys Arg Lys Cys Ile Phe Met Ser Glu Thr 
                485                 490                 495     


Gln Ser Ser Pro Thr Lys Gly Val Leu Met Tyr Gln Pro Ser Ser Val 
            500                 505                 510         


Arg Val Pro Ser Val Thr Ser Val Asp Pro Ala Ala Ile Pro Pro Ser 
        515                 520                 525             


Leu Thr Asp Tyr Ser Val Pro Phe His His Thr Pro Ile Ser Ser Met 
    530                 535                 540                 


Ser Ser Asp Leu Pro Gly Leu Asp Phe Leu Ser Leu Ile Pro Val Asp 
545                 550                 555                 560 


Pro Gln Tyr Cys Pro Pro Met Phe Leu Asp Ser Leu Thr Ser Pro Leu 
                565                 570                 575     


Thr Ala Ser Ser Thr Ser Val Thr Thr Thr Ser Ser His Glu Ser Ser 
            580                 585                 590         


Thr His Val Ser Ser Ser Ser Ser Arg Ser Glu Thr Gly Val Ile Thr 
        595                 600                 605             


Ser Ser Gly Ser Asn Ile Pro Asp Ile Ile Ser Leu Asp 
    610                 615                 620     


<210>  33
<211>  715
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Glu Leu Ala Asp Val Gly Ala Ala Ala Ser Ser Gln Gly Val His 
1               5                   10                  15      


Asp Gln Val Leu Pro Thr Pro Asn Ala Ser Ser Arg Val Ile Val His 
            20                  25                  30          


Val Asp Leu Asp Cys Phe Tyr Ala Gln Val Glu Met Ile Ser Asn Pro 
        35                  40                  45              


Glu Leu Lys Asp Lys Pro Leu Gly Val Gln Gln Lys Tyr Leu Val Val 
    50                  55                  60                  


Thr Cys Asn Tyr Glu Ala Arg Lys Leu Gly Val Lys Lys Leu Met Asn 
65                  70                  75                  80  


Val Arg Asp Ala Lys Glu Lys Cys Pro Gln Leu Val Leu Val Asn Gly 
                85                  90                  95      


Glu Asp Leu Thr Arg Tyr Arg Glu Met Ser Tyr Lys Val Thr Glu Leu 
            100                 105                 110         


Leu Glu Glu Phe Ser Pro Val Val Glu Arg Leu Gly Phe Asp Glu Asn 
        115                 120                 125             


Phe Val Asp Leu Thr Glu Met Val Glu Lys Arg Leu Gln Gln Leu Gln 
    130                 135                 140                 


Ser Asp Glu Leu Ser Ala Val Thr Val Ser Gly His Val Tyr Asn Asn 
145                 150                 155                 160 


Gln Ser Ile Asn Leu Leu Asp Val Leu His Ile Arg Leu Leu Val Gly 
                165                 170                 175     


Ser Gln Ile Ala Ala Glu Met Arg Glu Ala Met Tyr Asn Gln Leu Gly 
            180                 185                 190         


Leu Thr Gly Cys Ala Gly Val Ala Ser Asn Lys Leu Leu Ala Lys Leu 
        195                 200                 205             


Val Ser Gly Val Phe Lys Pro Asn Gln Gln Thr Val Leu Leu Pro Glu 
    210                 215                 220                 


Ser Cys Gln His Leu Ile His Ser Leu Asn His Ile Lys Glu Ile Pro 
225                 230                 235                 240 


Gly Ile Gly Tyr Lys Thr Ala Lys Cys Leu Glu Ala Leu Gly Ile Asn 
                245                 250                 255     


Ser Val Arg Asp Leu Gln Thr Phe Ser Pro Lys Ile Leu Glu Lys Glu 
            260                 265                 270         


Leu Gly Ile Ser Val Ala Gln Arg Ile Gln Lys Leu Ser Phe Gly Glu 
        275                 280                 285             


Asp Asn Ser Pro Val Ile Leu Ser Gly Pro Pro Gln Ser Phe Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Lys Lys Cys Ser Ser Glu Val Glu Ala Lys Asn Lys 
305                 310                 315                 320 


Ile Glu Glu Leu Leu Ala Ser Leu Leu Asn Arg Val Cys Gln Asp Gly 
                325                 330                 335     


Arg Lys Pro His Thr Val Arg Leu Ile Ile Arg Arg Tyr Ser Ser Glu 
            340                 345                 350         


Lys His Tyr Gly Arg Glu Ser Arg Gln Cys Pro Ile Pro Ser His Val 
        355                 360                 365             


Ile Gln Lys Leu Gly Thr Gly Asn Tyr Asp Val Met Thr Pro Met Val 
    370                 375                 380                 


Asp Ile Leu Met Lys Leu Phe Arg Asn Met Val Asn Val Lys Met Pro 
385                 390                 395                 400 


Phe His Leu Thr Leu Leu Ser Val Cys Phe Cys Asn Leu Lys Ala Leu 
                405                 410                 415     


Asn Thr Ala Lys Lys Gly Leu Ile Asp Tyr Tyr Leu Met Pro Ser Leu 
            420                 425                 430         


Ser Thr Thr Ser Arg Ser Gly Lys His Ser Phe Lys Met Lys Asp Thr 
        435                 440                 445             


His Met Glu Asp Phe Pro Lys Asp Lys Glu Thr Asn Arg Asp Phe Leu 
    450                 455                 460                 


Pro Ser Gly Arg Ile Glu Ser Thr Arg Thr Arg Glu Ser Pro Leu Asp 
465                 470                 475                 480 


Thr Thr Asn Phe Ser Lys Glu Lys Asp Ile Asn Glu Phe Pro Leu Cys 
                485                 490                 495     


Ser Leu Pro Glu Gly Val Asp Gln Glu Val Phe Lys Gln Leu Pro Val 
            500                 505                 510         


Asp Ile Gln Glu Glu Ile Leu Ser Gly Lys Ser Arg Glu Lys Phe Gln 
        515                 520                 525             


Gly Lys Gly Ser Val Ser Cys Pro Leu His Ala Ser Arg Gly Val Leu 
    530                 535                 540                 


Ser Phe Phe Ser Lys Lys Gln Met Gln Asp Ile Pro Ile Asn Pro Arg 
545                 550                 555                 560 


Asp His Leu Ser Ser Ser Lys Gln Val Ser Ser Val Ser Pro Cys Glu 
                565                 570                 575     


Pro Gly Thr Ser Gly Phe Asn Ser Ser Ser Ser Ser Tyr Met Ser Ser 
            580                 585                 590         


Gln Lys Asp Tyr Ser Tyr Tyr Leu Asp Asn Arg Leu Lys Asp Glu Arg 
        595                 600                 605             


Ile Ser Gln Gly Pro Lys Glu Pro Gln Gly Phe His Phe Thr Asn Ser 
    610                 615                 620                 


Asn Pro Ala Val Ser Ala Phe His Ser Phe Pro Asn Leu Gln Ser Glu 
625                 630                 635                 640 


Gln Leu Phe Ser Arg Asn His Thr Thr Asp Ser His Lys Gln Thr Val 
                645                 650                 655     


Ala Thr Asp Ser His Glu Gly Leu Thr Glu Asn Arg Glu Pro Asp Ser 
            660                 665                 670         


Val Asp Glu Lys Ile Thr Phe Pro Ser Asp Ile Asp Pro Gln Val Phe 
        675                 680                 685             


Tyr Glu Leu Pro Glu Ala Val Gln Lys Glu Leu Leu Ala Glu Trp Lys 
    690                 695                 700                 


Arg Ala Gly Ser Asp Phe His Ile Gly His Lys 
705                 710                 715 


<210>  34
<211>  696
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Ala Asp Met Asp Tyr Glu Arg Pro Asn Val Glu Thr Ile Lys 
1               5                   10                  15      


Cys Val Val Val Gly Asp Asn Ala Val Gly Lys Thr Arg Leu Ile Cys 
            20                  25                  30          


Ala Arg Ala Cys Asn Thr Thr Leu Thr Gln Tyr Gln Leu Leu Ala Thr 
        35                  40                  45              


His Val Pro Thr Val Trp Ala Ile Asp Gln Tyr Arg Val Cys Gln Glu 
    50                  55                  60                  


Val Leu Glu Arg Ser Arg Asp Val Val Asp Glu Val Ser Val Ser Leu 
65                  70                  75                  80  


Arg Leu Trp Asp Thr Phe Gly Asp His His Lys Asp Arg Arg Phe Ala 
                85                  90                  95      


Tyr Gly Arg Ser Asp Val Val Val Leu Cys Phe Ser Ile Ala Asn Pro 
            100                 105                 110         


Asn Ser Leu Asn His Val Lys Ser Met Trp Tyr Pro Glu Ile Lys His 
        115                 120                 125             


Phe Cys Pro Arg Thr Pro Val Ile Leu Val Gly Cys Gln Leu Asp Leu 
    130                 135                 140                 


Arg Tyr Ala Asp Leu Glu Ala Val Asn Arg Ala Arg Arg Pro Leu Ala 
145                 150                 155                 160 


Arg Pro Ile Lys Arg Gly Asp Ile Leu Pro Pro Glu Lys Gly Arg Glu 
                165                 170                 175     


Val Ala Lys Glu Leu Gly Leu Pro Tyr Tyr Glu Thr Ser Val Phe Asp 
            180                 185                 190         


Gln Phe Gly Ile Lys Asp Val Phe Asp Asn Ala Ile Arg Ala Ala Leu 
        195                 200                 205             


Ile Ser Arg Arg His Leu Gln Phe Trp Lys Ser His Leu Lys Lys Val 
    210                 215                 220                 


Gln Lys Pro Leu Leu Gln Ala Pro Phe Leu Pro Pro Lys Ala Pro Pro 
225                 230                 235                 240 


Pro Val Ile Lys Ile Pro Glu Cys Pro Ser Met Gly Thr Asn Glu Ala 
                245                 250                 255     


Ala Cys Leu Leu Asp Asn Pro Leu Cys Ala Asp Val Leu Phe Ile Leu 
            260                 265                 270         


Gln Asp Gln Glu His Ile Phe Ala His Arg Ile Tyr Leu Ala Thr Ser 
        275                 280                 285             


Ser Ser Lys Phe Tyr Asp Leu Phe Leu Met Glu Cys Glu Glu Ser Pro 
    290                 295                 300                 


Asn Gly Ser Glu Gly Ala Cys Glu Lys Glu Lys Gln Ser Arg Asp Phe 
305                 310                 315                 320 


Gln Gly Arg Ile Leu Ser Val Asp Pro Glu Glu Glu Arg Glu Glu Gly 
                325                 330                 335     


Pro Pro Arg Ile Pro Gln Ala Asp Gln Trp Lys Ser Ser Asn Lys Ser 
            340                 345                 350         


Leu Val Glu Ala Leu Gly Leu Glu Ala Glu Gly Ala Val Pro Glu Thr 
        355                 360                 365             


Gln Thr Leu Thr Gly Trp Ser Lys Gly Phe Ile Gly Met His Arg Glu 
    370                 375                 380                 


Met Gln Val Asn Pro Ile Ser Lys Arg Met Gly Pro Met Thr Val Val 
385                 390                 395                 400 


Arg Met Asp Ala Ser Val Gln Pro Gly Pro Phe Arg Thr Leu Leu Gln 
                405                 410                 415     


Phe Leu Tyr Thr Gly Gln Leu Asp Glu Lys Glu Lys Asp Leu Val Gly 
            420                 425                 430         


Leu Ala Gln Ile Ala Glu Val Leu Glu Met Phe Asp Leu Arg Met Met 
        435                 440                 445             


Val Glu Asn Ile Met Asn Lys Glu Ala Phe Met Asn Gln Glu Ile Thr 
    450                 455                 460                 


Lys Ala Phe His Val Arg Lys Ala Asn Arg Ile Lys Glu Cys Leu Ser 
465                 470                 475                 480 


Lys Gly Thr Phe Ser Asp Val Thr Phe Lys Leu Asp Asp Gly Ala Ile 
                485                 490                 495     


Ser Ala His Lys Pro Leu Leu Ile Cys Ser Cys Glu Trp Met Ala Ala 
            500                 505                 510         


Met Phe Gly Gly Ser Phe Val Glu Ser Ala Asn Ser Glu Val Tyr Leu 
        515                 520                 525             


Pro Asn Ile Asn Lys Ile Ser Met Gln Ala Val Leu Asp Tyr Leu Tyr 
    530                 535                 540                 


Thr Lys Gln Leu Ser Pro Asn Leu Asp Leu Asp Pro Leu Glu Leu Ile 
545                 550                 555                 560 


Ala Leu Ala Asn Arg Phe Cys Leu Pro His Leu Val Ala Leu Ala Glu 
                565                 570                 575     


Gln His Ala Val Gln Glu Leu Thr Lys Ala Ala Thr Ser Gly Val Gly 
            580                 585                 590         


Ile Asp Gly Glu Val Leu Ser Tyr Leu Glu Leu Ala Gln Phe His Asn 
        595                 600                 605             


Ala His Gln Leu Ala Ala Trp Cys Leu His His Ile Cys Thr Asn Tyr 
    610                 615                 620                 


Asn Ser Val Cys Ser Lys Phe Arg Lys Glu Ile Lys Ser Lys Ser Ala 
625                 630                 635                 640 


Asp Asn Gln Glu Tyr Phe Glu Arg His Arg Trp Pro Pro Val Trp Tyr 
                645                 650                 655     


Leu Lys Glu Glu Asp His Tyr Gln Arg Val Lys Arg Glu Arg Glu Lys 
            660                 665                 670         


Glu Asp Ile Ala Leu Asn Lys His Arg Ser Arg Arg Lys Trp Cys Phe 
        675                 680                 685             


Trp Asn Ser Ser Pro Ala Val Ala 
    690                 695     


<210>  35
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ile Thr Lys Phe Val Gln Asp Arg His Arg Ala Arg Arg Asn Arg 
1               5                   10                  15      


Leu Arg Lys Asp Gln Leu Lys Lys Leu Pro Val His Lys Phe Lys Lys 
            20                  25                  30          


Gly Asp Glu Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr Glu Asp 
        35                  40                  45              


Gly Asp Lys Leu Arg Ile Leu Pro Cys Ser His Ala Tyr His Cys Lys 
    50                  55                  60                  


Cys Val Asp Pro Trp Leu Thr Lys Thr Lys Lys Thr Cys Pro Val Cys 
65                  70                  75                  80  


Lys Gln Lys Val Val Pro Ser Gln Gly Asp Ser Asp Ser Asp Thr Asp 
                85                  90                  95      


Ser Ser Gln Glu Glu Asn Glu Val Thr Glu His Thr Pro Leu Leu Arg 
            100                 105                 110         


Pro Leu Ala Ser Val Ser Ala Gln Ser Phe Gly Ala Leu Ser Glu Ser 
        115                 120                 125             


Arg Ser His Gln Asn Met Thr Glu Ser Ser Asp Tyr Glu Glu Asp Asp 
    130                 135                 140                 


Asn Glu Asp Thr Asp Ser Ser Asp Ala Glu Asn Glu Ile Asn Glu His 
145                 150                 155                 160 


Asp Val Val Val Gln Leu Gln Pro Asn Gly Glu Arg Asp Tyr Asn Ile 
                165                 170                 175     


Ala Asn Thr Val 
            180 


<210>  36
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Thr Arg Lys Arg Arg Gly Gly Ala Ile Asn Ser Arg Gln Ala 
1               5                   10                  15      


Gln Lys Arg Thr Arg Glu Ala Thr Ser Thr Pro Glu Ile Ser Leu Glu 
            20                  25                  30          


Ala Glu Pro Ile Glu Leu Val Glu Thr Ala Gly Asp Glu Ile Val Asp 
        35                  40                  45              


Leu Thr Cys Glu Ser Leu Glu Pro Val Val Val Asp Leu Thr His Asn 
    50                  55                  60                  


Asp Ser Val Val Ile Val Asp Glu Arg Arg Arg Pro Arg Arg Asn Ala 
65                  70                  75                  80  


Arg Arg Leu Pro Gln Asp His Ala Asp Ser Cys Val Val Ser Ser Asp 
                85                  90                  95      


Asp Glu Glu Leu Ser Arg Asp Arg Asp Val Tyr Val Thr Thr His Thr 
            100                 105                 110         


Pro Arg Asn Ala Arg Asp Glu Gly Ala Thr Gly Leu Arg Pro Ser Gly 
        115                 120                 125             


Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Val Gln 
    130                 135                 140                 


Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His Val Phe Cys Ser 
145                 150                 155                 160 


Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro Thr Cys 
                165                 170                 175     


Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
            180                 185                 190 


<210>  37
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Ala Gly Ala Thr Ser Met Trp Ala Ser Cys Cys Gly Leu Leu 
1               5                   10                  15      


Asn Glu Val Met Gly Thr Gly Ala Val Arg Gly Gln Gln Ser Ala Phe 
            20                  25                  30          


Ala Gly Ala Thr Gly Pro Phe Arg Phe Thr Pro Asn Pro Glu Phe Ser 
        35                  40                  45              


Thr Tyr Pro Pro Ala Ala Thr Glu Gly Pro Asn Ile Val Cys Lys Ala 
    50                  55                  60                  


Cys Gly Leu Ser Phe Ser Val Phe Arg Lys Lys His Val Cys Cys Asp 
65                  70                  75                  80  


Cys Lys Lys Asp Phe Cys Ser Val Cys Ser Val Leu Gln Glu Asn Leu 
                85                  90                  95      


Arg Arg Cys Ser Thr Cys His Leu Leu Gln Glu Thr Ala Phe Gln Arg 
            100                 105                 110         


Pro Gln Leu Met Arg Leu Lys Val Lys Asp Leu Arg Gln Tyr Leu Ile 
        115                 120                 125             


Leu Arg Asn Ile Pro Ile Asp Thr Cys Arg Glu Lys Glu Asp Leu Val 
    130                 135                 140                 


Asp Leu Val Leu Cys His His Gly Leu Gly Ser Glu Asp Asp Met Asp 
145                 150                 155                 160 


Thr Ser Ser Leu Asn Ser Ser Arg Ser Gln Thr Ser Ser Phe Phe Thr 
                165                 170                 175     


Arg Ser Phe Phe Ser Asn Tyr Thr Ala Pro Ser Ala Thr Met Ser Ser 
            180                 185                 190         


Phe Gln Gly Glu Leu Met Asp Gly Asp Gln Thr Ser Arg Ser Gly Val 
        195                 200                 205             


Pro Ala Gln Val Gln Ser Glu Ile Thr Ser Ala Asn Thr Glu Asp Asp 
    210                 215                 220                 


Asp Asp Asp Asp Asp Glu Asp Asp Asp Asp Glu Glu Glu Asn Ala Glu 
225                 230                 235                 240 


Asp Arg Asn Pro Gly Leu Ser Lys Glu Arg Val Arg Ala Ser Leu Ser 
                245                 250                 255     


Asp Leu Ser Ser Leu Asp Asp Val Glu Gly Met Ser Val Arg Gln Leu 
            260                 265                 270         


Lys Glu Ile Leu Ala Arg Asn Phe Val Asn Tyr Ser Gly Cys Cys Glu 
        275                 280                 285             


Lys Trp Glu Leu Val Glu Lys Val Asn Arg Leu Tyr Lys Glu Asn Glu 
    290                 295                 300                 


Glu Asn Gln Lys Ser Tyr Gly Glu Arg Leu Gln Leu Gln Asp Glu Glu 
305                 310                 315                 320 


Asp Asp Ser Leu Cys Arg Ile Cys Met Asp Ala Val Ile Asp Cys Val 
                325                 330                 335     


Leu Leu Glu Cys Gly His Met Val Thr Cys Thr Lys Cys Gly Lys Arg 
            340                 345                 350         


Met Ser Glu Cys Pro Ile Cys Arg Gln Tyr Val Val Arg Ala Val His 
        355                 360                 365             


Val Phe Lys Ser 
    370         


<210>  38
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu Ala Val Ala 
1               5                   10                  15      


Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly Cys Glu Leu 
            20                  25                  30          


Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp Leu Ile Asp 
        35                  40                  45              


Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe Leu Phe Gln 
    50                  55                  60                  


Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys Glu Ser Val 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His Asp Ser Ile 
                85                  90                  95      


Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe Ile Leu Val 
            100                 105                 110         


Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val Asn Arg Met 
        115                 120                 125             


Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr Ala Gly Tyr 
    130                 135                 140                 


Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu Cys Tyr Glu 
145                 150                 155                 160 


Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys Thr Ile Arg 
                165                 170                 175     


Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala Lys Tyr Leu 
            180                 185                 190         


Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu Val Ser Pro 
        195                 200                 205             


Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu Ala Glu Ala 
    210                 215                 220                 


Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg Ile Ser Thr 
225                 230                 235                 240 


Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys Leu Phe Thr 
                245                 250                 255     


Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met Asp Lys Leu 
            260                 265                 270         


Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala Glu Val Gln 
        275                 280                 285             


Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn Glu Pro Gln 
    290                 295                 300                 


Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser Tyr Ala Arg 
305                 310                 315                 320 


Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu Ala Glu Lys 
                325                 330                 335     


Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro Ser Ala Met 
            340                 345                 350         


Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile Phe Ser Met 
        355                 360                 365             


Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly Asn Ile Ile 
    370                 375                 380                 


Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu Ile Val Leu 
385                 390                 395                 400 


Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys Arg Thr Ile 
                405                 410                 415     


Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu Val Pro Cys 
            420                 425                 430         


Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala Ser Lys Pro 
        435                 440                 445             


Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val Leu Thr Leu 
    450                 455                 460                 


Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala Pro Asp Val 
465                 470                 475                 480 


Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser Glu Glu Gly 
                485                 490                 495     


Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe Gly Ile Arg 
            500                 505                 510         


Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp Tyr Thr Leu 
        515                 520                 525             


Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp Val Glu Phe 
    530                 535                 540                 


Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys Gln Ala Glu 
545                 550                 555                 560 


Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly Ala Gln Pro 
                565                 570                 575     


Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile Val Asp Ser 
            580                 585                 590         


Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu Glu Glu Arg 
        595                 600                 605             


Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser Ala Lys Arg 
    610                 615                 620                 


Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile Ala Leu Asp 
625                 630                 635                 640 


<210>  39
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Leu Arg Ser Ser His Asn Ala Ser Lys Thr Leu Asn Ala Asn 
1               5                   10                  15      


Asn Met Glu Thr Leu Ile Glu Cys Gln Ser Glu Gly Asp Ile Lys Glu 
            20                  25                  30          


His Pro Leu Leu Ala Ser Cys Glu Ser Glu Asp Ser Ile Cys Gln Leu 
        35                  40                  45              


Ile Glu Val Lys Lys Arg Lys Lys Val Leu Ser Trp Pro Phe Leu Met 
    50                  55                  60                  


Arg Arg Leu Ser Pro Ala Ser Asp Phe Ser Gly Ala Leu Glu Thr Asp 
65                  70                  75                  80  


Leu Lys Ala Ser Leu Phe Asp Gln Pro Leu Ser Ile Ile Cys Gly Asp 
                85                  90                  95      


Ser Asp Thr Leu Pro Arg Pro Ile Gln Asp Ile Leu Thr Ile Leu Cys 
            100                 105                 110         


Leu Lys Gly Pro Ser Thr Glu Gly Ile Phe Arg Arg Ala Ala Asn Glu 
        115                 120                 125             


Lys Ala Arg Lys Glu Leu Lys Glu Glu Leu Asn Ser Gly Asp Ala Val 
    130                 135                 140                 


Asp Leu Glu Arg Leu Pro Val His Leu Leu Ala Val Val Phe Lys Asp 
145                 150                 155                 160 


Phe Leu Arg Ser Ile Pro Arg Lys Leu Leu Ser Ser Asp Leu Phe Glu 
                165                 170                 175     


Glu Trp Met Gly Ala Leu Glu Met Gln Asp Glu Glu Asp Arg Ile Glu 
            180                 185                 190         


Ala Leu Lys Gln Val Ala Asp Lys Leu Pro Arg Pro Asn Leu Leu Leu 
        195                 200                 205             


Leu Lys His Leu Val Tyr Val Leu His Leu Ile Ser Lys Asn Ser Glu 
    210                 215                 220                 


Val Asn Arg Met Asp Ser Ser Asn Leu Ala Ile Cys Ile Gly Pro Asn 
225                 230                 235                 240 


Met Leu Thr Leu Glu Asn Asp Gln Ser Leu Ser Phe Glu Ala Gln Lys 
                245                 250                 255     


Asp Leu Asn Asn Lys Val Lys Thr Leu Val Glu Phe Leu Ile Asp Asn 
            260                 265                 270         


Cys Phe Glu Ile Phe Gly Glu Asn Ile Pro Val His Ser Ser Ile Thr 
        275                 280                 285             


Ser Asp Asp Ser Leu Glu His Thr Asp Ser Ser Asp Val Ser Thr Leu 
    290                 295                 300                 


Gln Asn Asp Ser Ala Tyr Asp Ser Asn Asp Pro Asp Val Glu Ser Asn 
305                 310                 315                 320 


Ser Ser Ser Gly Ile Ser Ser Pro Ser Arg Gln Pro Gln Val Pro Met 
                325                 330                 335     


Ala Thr Ala Ala Gly Leu Asp Ser Ala Gly Pro Gln Asp Ala Arg Glu 
            340                 345                 350         


Val Ser Pro Glu Pro Ile Val Ser Thr Val Ala Arg Leu Lys Ser Ser 
        355                 360                 365             


Leu Ala Gln Pro Asp Arg Arg Tyr Ser Glu Pro Ser Met Pro Ser Ser 
    370                 375                 380                 


Gln Glu Cys Leu Glu Ser Arg Val Thr Asn Gln Thr Leu Thr Lys Ser 
385                 390                 395                 400 


Glu Gly Asp Phe Pro Val Pro Arg Val Gly Ser Arg Leu Glu Ser Glu 
                405                 410                 415     


Glu Ala Glu Asp Pro Phe Pro Glu Glu Val Phe Pro Ala Val Gln Gly 
            420                 425                 430         


Lys Thr Lys Arg Pro Val Asp Leu Lys Ile Lys Asn Leu Ala Pro Gly 
        435                 440                 445             


Ser Val Leu Pro Arg Ala Leu Val Leu Lys Ala Phe Ser Ser Ser Ser 
    450                 455                 460                 


Leu Asp Ala Ser Ser Asp Ser Ser Pro Val Ala Ser Pro Ser Ser Pro 
465                 470                 475                 480 


Lys Arg Asn Phe Phe Ser Arg His Gln Ser Phe Thr Thr Lys Thr Glu 
                485                 490                 495     


Lys Gly Lys Pro Ser Arg Glu Ile Lys Lys His Ser Met Ser Phe Thr 
            500                 505                 510         


Phe Ala Pro His Lys Lys Val Leu Thr Lys Asn Leu Ser Ala Gly Ser 
        515                 520                 525             


Gly Lys Ser Gln Asp Phe Thr Arg Asp His Val Pro Arg Gly Val Arg 
    530                 535                 540                 


Lys Glu Ser Gln Leu Ala Gly Arg Ile Val Gln Glu Asn Gly Cys Glu 
545                 550                 555                 560 


Thr His Asn Gln Thr Ala Arg Gly Phe Cys Leu Arg Pro His Ala Leu 
                565                 570                 575     


Ser Val Asp Asp Val Phe Gln Gly Ala Asp Trp Glu Arg Pro Gly Ser 
            580                 585                 590         


Pro Pro Ser Tyr Glu Glu Ala Met Gln Gly Pro Ala Ala Arg Leu Val 
        595                 600                 605             


Ala Ser Glu Ser Gln Thr Val Gly Ser Met Thr Val Gly Ser Met Arg 
    610                 615                 620                 


Ala Arg Met Leu Glu Ala His Cys Leu Leu Pro Pro Leu Pro Pro Ala 
625                 630                 635                 640 


His His Val Glu Asp Ser Arg His Arg Gly Ser Lys Glu Pro Leu Pro 
                645                 650                 655     


Gly His Gly Leu Ser Pro Leu Pro Glu Arg Trp Lys Gln Ser Arg Thr 
            660                 665                 670         


Val His Ala Ser Gly Asp Ser Leu Gly His Val Ser Gly Pro Gly Arg 
        675                 680                 685             


Pro Glu Leu Leu Pro Leu Arg Thr Val Ser Glu Ser Val Gln Arg Asn 
    690                 695                 700                 


Lys Arg Asp Cys Leu Val Arg Arg Cys Ser Gln Pro Val Phe Glu Ala 
705                 710                 715                 720 


Asp Gln Phe Gln Tyr Ala Lys Glu Ser Tyr Ile 
                725                 730     


<210>  40
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Pro Met His Leu Leu Gly Arg Leu Glu Lys Pro Leu Leu Leu 
1               5                   10                  15      


Leu Cys Cys Ala Ser Phe Leu Leu Gly Leu Ala Leu Leu Gly Ile Lys 
            20                  25                  30          


Thr Asp Ile Thr Pro Val Ala Tyr Phe Phe Leu Thr Leu Gly Gly Phe 
        35                  40                  45              


Phe Leu Phe Ala Tyr Leu Leu Val Arg Phe Leu Glu Trp Gly Leu Arg 
    50                  55                  60                  


Ser Gln Leu Gln Ser Met Gln Thr Glu Ser Pro Gly Pro Ser Gly Asn 
65                  70                  75                  80  


Ala Arg Asp Asn Glu Ala Phe Glu Val Pro Val Tyr Glu Glu Ala Val 
                85                  90                  95      


Val Gly Leu Glu Ser Gln Cys Arg Pro Gln Glu Leu Asp Gln Pro Pro 
            100                 105                 110         


Pro Tyr Ser Thr Val Val Ile Pro Pro Ala Pro Glu Glu Glu Gln Pro 
        115                 120                 125             


Ser His Pro Glu Gly Ser Arg Arg Ala Lys Leu Glu Gln Arg Arg Met 
    130                 135                 140                 


Ala Ser Glu Gly Ser Met Ala Gln Glu Gly Ser Pro Gly Arg Ala Pro 
145                 150                 155                 160 


Ile Asn Leu Arg Leu Arg Gly Pro Arg Ala Val Ser Thr Ala Pro Asp 
                165                 170                 175     


Leu Gln Ser Leu Ala Ala Val Pro Thr Leu Glu Pro Leu Thr Pro Pro 
            180                 185                 190         


Pro Ala Tyr Asp Val Cys Phe Gly His Pro Asp Asp Asp Ser Val Phe 
        195                 200                 205             


Tyr Glu Asp Asn Trp Ala Pro Pro 
    210                 215     


<210>  41
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Glu Gln Gly Ser Gly Arg Leu Glu Asp Phe Pro Val Asn Val Phe 
1               5                   10                  15      


Ser Val Thr Pro Tyr Thr Pro Ser Thr Ala Asp Ile Gln Val Ser Asp 
            20                  25                  30          


Asp Asp Lys Ala Gly Ala Thr Leu Leu Phe Ser Gly Ile Phe Leu Gly 
        35                  40                  45              


Leu Val Gly Ile Thr Phe Thr Val Met Gly Trp Ile Lys Tyr Gln Gly 
    50                  55                  60                  


Val Ser His Phe Glu Trp Thr Gln Leu Leu Gly Pro Val Leu Leu Ser 
65                  70                  75                  80  


Val Gly Val Thr Phe Ile Leu Ile Ala Val Cys Lys Phe Lys Met Leu 
                85                  90                  95      


Ser Cys Gln Leu Cys Lys Glu Ser Glu Glu Arg Val Pro Asp Ser Glu 
            100                 105                 110         


Gln Thr Pro Gly Gly Pro Ser Phe Val Phe Thr Gly Ile Asn Gln Pro 
        115                 120                 125             


Ile Thr Phe His Gly Ala Thr Val Val Gln Tyr Ile Pro Pro Pro Tyr 
    130                 135                 140                 


Gly Ser Pro Glu Pro Met Gly Ile Asn Thr Ser Tyr Leu Gln Ser Val 
145                 150                 155                 160 


Val Ser Pro Cys Gly Leu Ile Thr Ser Gly Gly Ala Ala Ala Ala Met 
                165                 170                 175     


Ser Ser Pro Pro Gln Tyr Tyr Thr Ile Tyr Pro Gln Asp Asn Ser Ala 
            180                 185                 190         


Phe Val Val Asp Glu Gly Cys Leu Ser Phe Thr Asp Gly Gly Asn His 
        195                 200                 205             


Arg Pro Asn Pro Asp Val Asp Gln Leu Glu Glu Thr Gln Leu Glu Glu 
    210                 215                 220                 


Glu Ala Cys Ala Cys Phe Ser Pro Pro Pro Tyr Glu Glu Ile Tyr Ser 
225                 230                 235                 240 


Leu Pro Arg 
            


<210>  42
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Ala Asp Gly Glu Arg Ser Pro Leu Leu Ser Glu Pro Ile Asp 
1               5                   10                  15      


Gly Gly Ala Gly Gly Asn Gly Leu Val Gly Pro Gly Gly Ser Gly Ala 
            20                  25                  30          


Gly Pro Gly Gly Gly Leu Thr Pro Ser Ala Pro Pro Tyr Gly Ala Ala 
        35                  40                  45              


Phe Pro Pro Phe Pro Glu Gly His Pro Ala Val Leu Pro Gly Glu Asp 
    50                  55                  60                  


Pro Pro Pro Tyr Ser Pro Leu Thr Ser Pro Asp Ser Gly Ser Ala Pro 
65                  70                  75                  80  


Met Ile Thr Cys Arg Val Cys Gln Ser Leu Ile Asn Val Glu Gly Lys 
                85                  90                  95      


Met His Gln His Val Val Lys Cys Gly Val Cys Asn Glu Ala Thr Pro 
            100                 105                 110         


Ile Lys Asn Ala Pro Pro Gly Lys Lys Tyr Val Arg Cys Pro Cys Asn 
        115                 120                 125             


Cys Leu Leu Ile Cys Lys Val Thr Ser Gln Arg Ile Ala Cys Pro Arg 
    130                 135                 140                 


Pro Tyr Cys Lys Arg Ile Ile Asn Leu Gly Pro Val His Pro Gly Pro 
145                 150                 155                 160 


Leu Ser Pro Glu Pro Gln Pro Met Gly Val Arg Val Ile Cys Gly His 
                165                 170                 175     


Cys Lys Asn Thr Phe Leu Trp Thr Glu Phe Thr Asp Arg Thr Leu Ala 
            180                 185                 190         


Arg Cys Pro His Cys Arg Lys Val Ser Ser Ile Gly Arg Arg Tyr Pro 
        195                 200                 205             


Arg Lys Arg Cys Ile Cys Cys Phe Leu Leu Gly Leu Leu Leu Ala Val 
    210                 215                 220                 


Thr Ala Thr Gly Leu Ala Phe Gly Thr Trp Lys His Ala Arg Arg Tyr 
225                 230                 235                 240 


Gly Gly Ile Tyr Ala Ala Trp Ala Phe Val Ile Leu Leu Ala Val Leu 
                245                 250                 255     


Cys Leu Gly Arg Ala Leu Tyr Trp Ala Cys Met Lys Val Ser His Pro 
            260                 265                 270         


Val Gln Asn Phe Ser 
        275         


<210>  43
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  43

Met His Arg Leu Met Gly Val Asn Ser Thr Ala Ala Ala Ala Ala Gly 
1               5                   10                  15      


Gln Pro Asn Val Ser Cys Thr Cys Asn Cys Lys Arg Ser Leu Phe Gln 
            20                  25                  30          


Ser Met Glu Ile Thr Glu Leu Glu Phe Val Gln Ile Ile Ile Ile Val 
        35                  40                  45              


Val Val Met Met Val Met Val Val Val Ile Thr Cys Leu Leu Ser His 
    50                  55                  60                  


Tyr Lys Leu Ser Ala Arg Ser Phe Ile Ser Arg His Ser Gln Gly Arg 
65                  70                  75                  80  


Arg Arg Glu Asp Ala Leu Ser Ser Glu Gly Cys Leu Trp Pro Ser Glu 
                85                  90                  95      


Ser Thr Val Ser Gly Asn Gly Ile Pro Glu Pro Gln Val Tyr Ala Pro 
            100                 105                 110         


Pro Arg Pro Thr Asp Arg Leu Ala Val Pro Pro Phe Ala Gln Arg Glu 
        115                 120                 125             


Arg Phe His Arg Phe Gln Pro Thr Tyr Pro Tyr Leu Gln His Glu Ile 
    130                 135                 140                 


Asp Leu Pro Pro Thr Ile Ser Leu Ser Asp Gly Glu Glu Pro Pro Pro 
145                 150                 155                 160 


Tyr Gln Gly Pro Cys Thr Leu Gln Leu Arg Asp Pro Glu Gln Gln Leu 
                165                 170                 175     


Glu Leu Asn Arg Glu Ser Val Arg Ala Pro Pro Asn Arg Thr Ile Phe 
            180                 185                 190         


Asp Ser Asp Leu Met Asp Ser Ala Arg Leu Gly Gly Pro Cys Pro Pro 
        195                 200                 205             


Ser Ser Asn Ser Gly Ile Ser Ala Thr Cys Tyr Gly Ser Gly Gly Arg 
    210                 215                 220                 


Met Glu Gly Pro Pro Pro Thr Tyr Ser Glu Val Ile Gly His Tyr Pro 
225                 230                 235                 240 


Gly Ser Ser Phe Gln His Gln Gln Ser Ser Gly Pro Pro Ser Leu Leu 
                245                 250                 255     


Glu Gly Thr Arg Leu His His Thr His Ile Ala Pro Leu Glu Ser Ala 
            260                 265                 270         


Ala Ile Trp Ser Lys Glu Lys Asp Lys Gln Lys Gly His Pro Leu 
        275                 280                 285         


<210>  44
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  45
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ser Arg Ser Arg Leu Phe Ser Val Thr Ser Ala Ile Ser Thr Ile 
1               5                   10                  15      


Gly Ile Leu Cys Leu Pro Leu Phe Gln Leu Val Leu Ser Asp Leu Pro 
            20                  25                  30          


Cys Glu Glu Asp Glu Met Cys Val Asn Tyr Asn Asp Gln His Pro Asn 
        35                  40                  45              


Gly Trp Tyr Ile Trp Ile Leu Leu Leu Leu Val Leu Val Ala Ala Leu 
    50                  55                  60                  


Leu Cys Gly Ala Val Val Leu Cys Leu Gln Cys Trp Leu Arg Arg Pro 
65                  70                  75                  80  


Arg Ile Asp Ser His Arg Arg Thr Met Ala Val Phe Ala Val Gly Asp 
                85                  90                  95      


Leu Asp Ser Ile Tyr Gly Thr Glu Ala Ala Val Ser Pro Thr Val Gly 
            100                 105                 110         


Ile His Leu Gln Thr Gln Thr Pro Asp Leu Tyr Pro Val Pro Ala Pro 
        115                 120                 125             


Cys Phe Gly Pro Leu Gly Ser Pro Pro Pro Tyr Glu Glu Ile Val Lys 
    130                 135                 140                 


Thr Thr 
145     


<210>  46
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Glu Ala Ser Ala Ala Gly Ala Asp Ser Gly Ala Ala Val Ala 
1               5                   10                  15      


Ala His Arg Phe Phe Cys His Phe Cys Lys Gly Glu Val Ser Pro Lys 
            20                  25                  30          


Leu Pro Glu Tyr Ile Cys Pro Arg Cys Glu Ser Gly Phe Ile Glu Glu 
        35                  40                  45              


Val Thr Asp Asp Ser Ser Phe Leu Gly Gly Gly Gly Ser Arg Ile Asp 
    50                  55                  60                  


Asn Thr Thr Thr Thr His Phe Ala Glu Leu Trp Gly His Leu Asp His 
65                  70                  75                  80  


Thr Met Phe Phe Gln Asp Phe Arg Pro Phe Leu Ser Ser Ser Pro Leu 
                85                  90                  95      


Asp Gln Asp Asn Arg Ala Asn Glu Arg Gly His Gln Thr His Thr Asp 
            100                 105                 110         


Phe Trp Gly Ala Arg Pro Pro Arg Leu Pro Leu Gly Arg Arg Tyr Arg 
        115                 120                 125             


Ser Arg Gly Ser Ser Arg Pro Asp Arg Ser Pro Ala Ile Glu Gly Ile 
    130                 135                 140                 


Leu Gln His Ile Phe Ala Gly Phe Phe Ala Asn Ser Ala Ile Pro Gly 
145                 150                 155                 160 


Ser Pro His Pro Phe Ser Trp Ser Gly Met Leu His Ser Asn Pro Gly 
                165                 170                 175     


Asp Tyr Ala Trp Gly Gln Thr Gly Leu Asp Ala Ile Val Thr Gln Leu 
            180                 185                 190         


Leu Gly Gln Leu Glu Asn Thr Gly Pro Pro Pro Ala Asp Lys Glu Lys 
        195                 200                 205             


Ile Thr Ser Leu Pro Thr Val Thr Val Thr Gln Glu Gln Val Asp Met 
    210                 215                 220                 


Gly Leu Glu Cys Pro Val Cys Lys Glu Asp Tyr Thr Val Glu Glu Glu 
225                 230                 235                 240 


Val Arg Gln Leu Pro Cys Asn His Phe Phe His Ser Ser Cys Ile Val 
                245                 250                 255     


Pro Trp Leu Glu Leu His Asp Thr Cys Pro Val Cys Arg Lys Ser Leu 
            260                 265                 270         


Asn Gly Glu Asp Ser Thr Arg Gln Ser Gln Ser Thr Glu Ala Ser Ala 
        275                 280                 285             


Ser Asn Arg Phe Ser Asn Asp Ser Gln Leu His Asp Arg Trp Thr Phe 
    290                 295                 300                 


