                         SEQUENCE LISTING

<110>  DNA Script SAS        
 
<120>  VARIANTS OF TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE AND USES 
       THEREOF

<130>  B3000PC00

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  PRT
<213>  Mus musculus

<400>  1

Met Asp Pro Leu Gln Ala Val His Leu Gly Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Leu Gly Thr Pro Val Ala Ser Thr Pro Tyr Asp Ile Arg Phe 
            20                  25                  30          


Arg Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Leu Gln Leu Gln Asn Ile Lys Ala Ser 
                85                  90                  95      


Ser Glu Leu Glu Leu Leu Asp Ile Ser Trp Leu Ile Glu Cys Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Met Gly Arg His Gln Leu Val Val Asn 
        115                 120                 125             


Arg Asn Ser Ser Pro Ser Pro Val Pro Gly Ser Gln Asn Val Pro Ala 
    130                 135                 140                 


Pro Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Tyr Asn Gln Leu Phe Thr Asp Ala Leu Asp Ile Leu Ala 
                165                 170                 175     


Glu Asn Asp Glu Leu Arg Glu Asn Glu Gly Ser Cys Leu Ala Phe Met 
            180                 185                 190         


Arg Ala Ser Ser Val Leu Lys Ser Leu Pro Phe Pro Ile Thr Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Ser Ile 
    210                 215                 220                 


Ile Glu Gly Ile Ile Glu Asp Gly Glu Ser Ser Glu Ala Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Arg Phe Thr Gln Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Asn 
    290                 295                 300                 


Arg Pro Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu Ala Val Val 
305                 310                 315                 320 


Thr Phe Leu Pro Asp Ala Leu Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Met Thr Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu 
            340                 345                 350         


Ala Thr Glu Asp Glu Glu Gln Gln Leu Leu His Lys Val Thr Asp Phe 
        355                 360                 365             


Trp Lys Gln Gln Gly Leu Leu Leu Tyr Cys Asp Ile Leu Glu Ser Thr 
    370                 375                 380                 


Phe Glu Lys Phe Lys Gln Pro Ser Arg Lys Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Asp His Gly Arg Val His 
                405                 410                 415     


Ser Glu Lys Ser Gly Gln Gln Glu Gly Lys Gly Trp Lys Ala Ile Arg 
            420                 425                 430         


Val Asp Leu Val Met Cys Pro Tyr Asp Arg Arg Ala Phe Ala Leu Leu 
        435                 440                 445             


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
    450                 455                 460                 


Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Arg 
465                 470                 475                 480 


Thr Lys Arg Val Phe Leu Glu Ala Glu Ser Glu Glu Glu Ile Phe Ala 
                485                 490                 495     


His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510 


<210>  2
<211>  381
<212>  PRT
<213>  Mus musculus

<400>  2

Asn Ser Ser Pro Ser Pro Val Pro Gly Ser Gln Asn Val Pro Ala Pro 
1               5                   10                  15      


Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn Tyr Asn Gln Leu Phe Thr Asp Ala Leu Asp Ile Leu Ala Glu 
        35                  40                  45              


Asn Asp Glu Leu Arg Glu Asn Glu Gly Ser Cys Leu Ala Phe Met Arg 
    50                  55                  60                  


Ala Ser Ser Val Leu Lys Ser Leu Pro Phe Pro Ile Thr Ser Met Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Ser Ile Ile 
                85                  90                  95      


Glu Gly Ile Ile Glu Asp Gly Glu Ser Ser Glu Ala Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Arg Phe Thr Gln Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Asn Arg 
                165                 170                 175     


Pro Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu Ala Val Val Thr 
            180                 185                 190         


Phe Leu Pro Asp Ala Leu Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Met Thr Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Ala 
    210                 215                 220                 


Thr Glu Asp Glu Glu Gln Gln Leu Leu His Lys Val Thr Asp Phe Trp 
225                 230                 235                 240 


Lys Gln Gln Gly Leu Leu Leu Tyr Cys Asp Ile Leu Glu Ser Thr Phe 
                245                 250                 255     


Glu Lys Phe Lys Gln Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Leu Ile Leu Lys Leu Asp His Gly Arg Val His Ser 
        275                 280                 285             


Glu Lys Ser Gly Gln Gln Glu Gly Lys Gly Trp Lys Ala Ile Arg Val 
    290                 295                 300                 


Asp Leu Val Met Cys Pro Tyr Asp Arg Arg Ala Phe Ala Leu Leu Gly 
305                 310                 315                 320 


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr 
                325                 330                 335     


His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Arg Thr 
            340                 345                 350         


Lys Arg Val Phe Leu Glu Ala Glu Ser Glu Glu Glu Ile Phe Ala His 
        355                 360                 365             


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380     


<210>  3
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Pro Lys Arg Arg Arg Ala Arg Val Gly Ser Pro Ser Gly Asp 
1               5                   10                  15      


Ala Ala Ser Ser Thr Pro Pro Ser Thr Arg Phe Pro Gly Val Ala Ile 
            20                  25                  30          


Tyr Leu Val Glu Pro Arg Met Gly Arg Ser Arg Arg Ala Phe Leu Thr 
        35                  40                  45              


Gly Leu Ala Arg Ser Lys Gly Phe Arg Val Leu Asp Ala Cys Ser Ser 
    50                  55                  60                  


Glu Ala Thr His Val Val Met Glu Glu Thr Ser Ala Glu Glu Ala Val 
65                  70                  75                  80  


Ser Trp Gln Glu Arg Arg Met Ala Ala Ala Pro Pro Gly Cys Thr Pro 
                85                  90                  95      


Pro Ala Leu Leu Asp Ile Ser Trp Leu Thr Glu Ser Leu Gly Ala Gly 
            100                 105                 110         


Gln Pro Val Pro Val Glu Cys Arg His Arg Leu Glu Val Ala Gly Pro 
        115                 120                 125             


Arg Lys Gly Pro Leu Ser Pro Ala Trp Met Pro Ala Tyr Ala Cys Gln 
    130                 135                 140                 


Arg Pro Thr Pro Leu Thr His His Asn Thr Gly Leu Ser Glu Ala Leu 
145                 150                 155                 160 


Glu Ile Leu Ala Glu Ala Ala Gly Phe Glu Gly Ser Glu Gly Arg Leu 
                165                 170                 175     


Leu Thr Phe Cys Arg Ala Ala Ser Val Leu Lys Ala Leu Pro Ser Pro 
            180                 185                 190         


Val Thr Thr Leu Ser Gln Leu Gln Gly Leu Pro His Phe Gly Glu His 
        195                 200                 205             


Ser Ser Arg Val Val Gln Glu Leu Leu Glu His Gly Val Cys Glu Glu 
    210                 215                 220                 


Val Glu Arg Val Arg Arg Ser Glu Arg Tyr Gln Thr Met Lys Leu Phe 
225                 230                 235                 240 


Thr Gln Ile Phe Gly Val Gly Val Lys Thr Ala Asp Arg Trp Tyr Arg 
                245                 250                 255     


Glu Gly Leu Arg Thr Leu Asp Asp Leu Arg Glu Gln Pro Gln Lys Leu 
            260                 265                 270         


Thr Gln Gln Gln Lys Ala Gly Leu Gln His His Gln Asp Leu Ser Thr 
        275                 280                 285             


Pro Val Leu Arg Ser Asp Val Asp Ala Leu Gln Gln Val Val Glu Glu 
    290                 295                 300                 


Ala Val Gly Gln Ala Leu Pro Gly Ala Thr Val Thr Leu Thr Gly Gly 
305                 310                 315                 320 


Phe Arg Arg Gly Lys Leu Gln Gly His Asp Val Asp Phe Leu Ile Thr 
                325                 330                 335     


His Pro Lys Glu Gly Gln Glu Ala Gly Leu Leu Pro Arg Val Met Cys 
            340                 345                 350         


Arg Leu Gln Asp Gln Gly Leu Ile Leu Tyr His Gln His Gln His Ser 
        355                 360                 365             


Cys Cys Glu Ser Pro Thr Arg Leu Ala Gln Gln Ser His Met Asp Ala 
    370                 375                 380                 


Phe Glu Arg Ser Phe Cys Ile Phe Arg Leu Pro Gln Pro Pro Gly Ala 
385                 390                 395                 400 


Ala Val Gly Gly Ser Thr Arg Pro Cys Pro Ser Trp Lys Ala Val Arg 
                405                 410                 415     


Val Asp Leu Val Val Ala Pro Val Ser Gln Phe Pro Phe Ala Leu Leu 
            420                 425                 430         


Gly Trp Thr Gly Ser Lys Leu Phe Gln Arg Glu Leu Arg Arg Phe Ser 
        435                 440                 445             


Arg Lys Glu Lys Gly Leu Trp Leu Asn Ser His Gly Leu Phe Asp Pro 
    450                 455                 460                 


Glu Gln Lys Thr Phe Phe Gln Ala Ala Ser Glu Glu Asp Ile Phe Arg 
465                 470                 475                 480 


His Leu Gly Leu Glu Tyr Leu Pro Pro Glu Gln Arg Asn Ala 
                485                 490                 


<210>  4
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val 
1               5                   10                  15      


Pro Arg Gly Ser His Met Ser Pro Ser Pro Val Pro Gly Ser Gln Asn 
            20                  25                  30          


Val Pro Ala Pro Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg 
        35                  40                  45              


Arg Thr Thr Leu Asn Asn Tyr Asn Gln Leu Phe Thr Asp Ala Leu Asp 
    50                  55                  60                  


Ile Leu Ala Glu Asn Asp Glu Leu Arg Glu Asn Glu Gly Ser Cys Leu 
65                  70                  75                  80  


Ala Phe Met Arg Ala Ser Ser Val Leu Lys Ser Leu Pro Phe Pro Ile 
                85                  90                  95      


Thr Ser Met Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val 
            100                 105                 110         


Lys Ser Ile Ile Glu Gly Ile Ile Glu Asp Gly Glu Ser Ser Glu Ala 
        115                 120                 125             


Lys Ala Val Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr 
    130                 135                 140                 


Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Met 
145                 150                 155                 160 


Gly Phe Arg Thr Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Arg Phe 
                165                 170                 175     


Thr Gln Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser 
            180                 185                 190         


Cys Val Asn Arg Pro Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu 
        195                 200                 205             


Ala Val Val Thr Phe Leu Pro Asp Ala Leu Val Thr Met Thr Gly Gly 
    210                 215                 220                 


Phe Arg Arg Gly Lys Met Thr Gly His Asp Val Asp Phe Leu Ile Thr 
225                 230                 235                 240 


Ser Pro Glu Ala Thr Glu Asp Glu Glu Gln Gln Leu Leu His Lys Val 
                245                 250                 255     


Thr Asp Phe Trp Lys Gln Gln Gly Leu Leu Leu Tyr Cys Asp Ile Leu 
            260                 265                 270         


Glu Ser Thr Phe Glu Lys Phe Lys Gln Pro Ser Arg Lys Val Asp Ala 
        275                 280                 285             


Leu Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Asp His Gly 
    290                 295                 300                 


Arg Val His Ser Glu Lys Ser Gly Gln Gln Glu Gly Lys Gly Trp Lys 
305                 310                 315                 320 


Ala Ile Arg Val Asp Leu Val Met Cys Pro Tyr Asp Arg Arg Ala Phe 
                325                 330                 335     


Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg 
            340                 345                 350         


Arg Tyr Ala Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu 
        355                 360                 365             


Tyr Asp Arg Thr Lys Arg Val Phe Leu Glu Ala Glu Ser Glu Glu Glu 
    370                 375                 380                 


Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn 
385                 390                 395                 400 


Ala 
    


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  t7-pro primer

<400>  5
taatacgact cactataggg                                                   20


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7-ter primer

<400>  6
gctagttatt gctcagcgg                                                    19


<210>  7
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
aaaaaaaaaa aaaagggg                                                     18


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
tttttttttt ttaaataagg                                                   20


<210>  9
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Reference TdT variant

<400>  9

Thr Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val 
1               5                   10                  15      


Pro Arg Gly Ser His Met Ser Pro Ser Pro Val Pro Gly Ser Gln Asn 
            20                  25                  30          


Val Pro Ala Pro Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg 
        35                  40                  45              


Arg Thr Thr Leu Asn Asn Tyr Asn Gln Leu Phe Thr Asp Ala Leu Asp 
    50                  55                  60                  


Ile Leu Ala Glu Asn Asp Glu Leu Arg Glu Asn Glu Gly Ser Cys Leu 
65                  70                  75                  80  


Ala Phe Met Arg Ala Ser Ser Val Leu Lys Ser Leu Pro Phe Pro Ile 
                85                  90                  95      


Thr Ser Met Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val 
            100                 105                 110         


Lys Ser Ile Ile Glu Gly Ile Ile Glu Asp Gly Glu Ser Ser Glu Ala 
        115                 120                 125             


Lys Ala Val Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr 
    130                 135                 140                 


Ser Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Met 
145                 150                 155                 160 


Gly Phe Arg Thr Leu Ser Lys Ile Gln Ser Asp Lys Ser Leu Arg Phe 
                165                 170                 175     


Thr Gln Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser 
            180                 185                 190         


Cys Val Asn Arg Pro Glu Ala Glu Ala Val Ser Met Leu Val Lys Glu 
        195                 200                 205             


Ala Val Val Thr Phe Leu Pro Asp Ala Leu Val Thr Met Thr Gly Gly 
    210                 215                 220                 


Phe Arg Arg Gly Lys Met Thr Gly His Asp Val Asp Phe Leu Ile Thr 
225                 230                 235                 240 


Ser Pro Glu Ala Thr Glu Asp Glu Glu Gln Gln Leu Leu His Lys Val 
                245                 250                 255     


Thr Asp Phe Trp Lys Gln Gln Gly Leu Leu Leu Tyr Cys Asp Ile Leu 
            260                 265                 270         


Glu Ser Thr Phe Glu Lys Phe Lys Gln Pro Ser Arg Lys Val Asp Ala 
        275                 280                 285             


Leu Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Asp His Gly 
    290                 295                 300                 


Arg Val His Ser Glu Lys Ser Gly Gln Gln Glu Gly Lys Gly Trp Lys 
305                 310                 315                 320 


Ala Ile Arg Val Asp Leu Val Met Cys Pro Tyr Asp Arg Arg Ala Phe 
                325                 330                 335     


Ala Leu Leu Gly Trp Thr Gly Ser Ala Gln Phe Ser Arg Asp Leu Arg 
            340                 345                 350         


Arg Tyr Ala Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu 
        355                 360                 365             


Tyr Asp Arg Thr Lys Arg Val Phe Leu Glu Ala Glu Ser Glu Glu Glu 
    370                 375                 380                 


Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn 
385                 390                 395                 400 


Ala 
    


<210>  10
<211>  519
<212>  PRT
<213>  Bos taurus

<400>  10

Met Ala Gln Gln Arg Gln His Gln Arg Leu Pro Met Asp Pro Leu Cys 
1               5                   10                  15      


Thr Ala Ser Ser Gly Pro Arg Lys Lys Arg Pro Arg Gln Val Gly Ala 
            20                  25                  30          


Ser Met Ala Ser Pro Pro His Asp Ile Lys Phe Gln Asn Leu Val Leu 
        35                  40                  45              


Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg Arg Asn Phe Leu Met 
    50                  55                  60                  


Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu Asn Glu Leu Ser Asp 
65                  70                  75                  80  


Ser Val Thr His Ile Val Ala Glu Asn Asn Ser Gly Ser Glu Val Leu 
                85                  90                  95      


Glu Trp Leu Gln Val Gln Asn Ile Arg Ala Ser Ser Gln Leu Glu Leu 
            100                 105                 110         


Leu Asp Val Ser Trp Leu Ile Glu Ser Met Gly Ala Gly Lys Pro Val 
        115                 120                 125             


Glu Ile Thr Gly Lys His Gln Leu Val Val Arg Thr Asp Tyr Ser Ala 
    130                 135                 140                 


Thr Pro Asn Pro Gly Phe Gln Lys Thr Pro Pro Leu Ala Val Lys Lys 
145                 150                 155                 160 


Ile Ser Gln Tyr Ala Cys Gln Arg Lys Thr Thr Leu Asn Asn Tyr Asn 
                165                 170                 175     


His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala Glu Asn Ser Glu Phe 
            180                 185                 190         


Lys Glu Asn Glu Val Ser Tyr Val Thr Phe Met Arg Ala Ala Ser Val 
        195                 200                 205             


Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys Asp Thr Glu Gly 
    210                 215                 220                 


Ile Pro Cys Leu Gly Asp Lys Val Lys Cys Ile Ile Glu Glu Ile Ile 
225                 230                 235                 240 


Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu Asn Asp Glu Arg 
                245                 250                 255     


Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys 
            260                 265                 270         


Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Ser Leu Ser Lys Ile 
        275                 280                 285             


Met Ser Asp Lys Thr Leu Lys Phe Thr Lys Met Gln Lys Ala Gly Phe 
    290                 295                 300                 


Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg Ala Glu Ala Glu 
305                 310                 315                 320 


Ala Val Gly Val Leu Val Lys Glu Ala Val Trp Ala Phe Leu Pro Asp 
                325                 330                 335     


Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg Gly Lys Lys Ile Gly 
            340                 345                 350         


His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser Ala Glu Asp Glu 
        355                 360                 365             


Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Lys Lys Gly Leu 
    370                 375                 380                 


Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Glu Lys Phe Lys Leu 
385                 390                 395                 400 


Pro Ser Arg Gln Val Asp Thr Leu Asp His Phe Gln Lys Cys Phe Leu 
                405                 410                 415     


Ile Leu Lys Leu His His Gln Arg Val Asp Ser Ser Lys Ser Asn Gln 
            420                 425                 430         


Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val Asp Leu Val Met Cys 
        435                 440                 445             


Pro Tyr Glu Asn Arg Ala Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg 
    450                 455                 460                 


Gln Phe Glu Arg Asp Ile Arg Arg Tyr Ala Thr His Glu Arg Lys Met 
465                 470                 475                 480 


Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Arg Val Phe Leu 
                485                 490                 495     


Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu Asp Tyr 
            500                 505                 510         


Ile Glu Pro Trp Glu Arg Asn 
        515                 


<210>  11
<211>  380
<212>  PRT
<213>  Bos taurus

<400>  11

Asp Tyr Ser Ala Thr Pro Asn Pro Gly Phe Gln Lys Thr Pro Pro Leu 
1               5                   10                  15      


Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Lys Thr Thr Leu 
            20                  25                  30          


Asn Asn Tyr Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala Glu 
        35                  40                  45              


Asn Ser Glu Phe Lys Glu Asn Glu Val Ser Tyr Val Thr Phe Met Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Lys Val Lys Cys Ile Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Ser 
    130                 135                 140                 


Leu Ser Lys Ile Met Ser Asp Lys Thr Leu Lys Phe Thr Lys Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg 
                165                 170                 175     


Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Trp Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser 
    210                 215                 220                 


Ala Glu Asp Glu Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu 
225                 230                 235                 240 


Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Glu 
                245                 250                 255     


Lys Phe Lys Leu Pro Ser Arg Gln Val Asp Thr Leu Asp His Phe Gln 
            260                 265                 270         


Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Ser Ser 
        275                 280                 285             


Lys Ser Asn Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val Asp 
    290                 295                 300                 


Leu Val Met Cys Pro Tyr Glu Asn Arg Ala Phe Ala Leu Leu Gly Trp 
305                 310                 315                 320 


Thr Gly Ser Arg Gln Phe Glu Arg Asp Ile Arg Arg Tyr Ala Thr His 
                325                 330                 335     


Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys 
            340                 345                 350         


Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His Leu 
        355                 360                 365             


Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380 


<210>  12
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Pro Pro Arg Ala Ser His Leu Ser Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Thr Gly Ala Leu Met Ala Ser Ser Pro Gln Asp Ile Lys Phe 
            20                  25                  30          


Gln Asp Leu Val Val Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Leu Gln Ala Gln Lys Val Gln Val Ser 
                85                  90                  95      


Ser Gln Pro Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Ile Arg 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Lys His Gln Leu Val Val Arg 
        115                 120                 125             


Arg Asp Tyr Ser Asp Ser Thr Asn Pro Gly Pro Pro Lys Thr Pro Pro 
    130                 135                 140                 


Ile Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn Gln Ile Phe Thr Asp Ala Phe Asp Ile Leu Ala 
                165                 170                 175     


Glu Asn Cys Glu Phe Arg Glu Asn Glu Asp Ser Cys Val Thr Phe Met 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met 
        195                 200                 205             


Lys Asp Thr Glu Gly Ile Pro Cys Leu Gly Ser Lys Val Lys Gly Ile 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Lys Val Arg Ser Asp Lys Ser Leu Lys Phe Thr Arg Met 
        275                 280                 285             


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Ser Val Leu Val Lys Glu Ala Val Trp 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Thr Glu Asp Glu Glu Gln Leu Leu Gln Lys Val Met Asn Leu Trp 
        355                 360                 365             


Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe 
    370                 375                 380                 


Glu Lys Leu Arg Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
385                 390                 395                 400 


Gln Lys Cys Phe Leu Ile Phe Lys Leu Pro Arg Gln Arg Val Asp Ser 
                405                 410                 415     


Asp Gln Ser Ser Trp Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val 
            420                 425                 430         


Asp Leu Val Leu Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly 
        435                 440                 445             


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr 
    450                 455                 460                 


His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
465                 470                 475                 480 


Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His 
                485                 490                 495     


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 


<210>  13
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  13

Asp Tyr Ser Asp Ser Thr Asn Pro Gly Pro Pro Lys Thr Pro Pro Ile 
1               5                   10                  15      


Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn Cys Asn Gln Ile Phe Thr Asp Ala Phe Asp Ile Leu Ala Glu 
        35                  40                  45              


Asn Cys Glu Phe Arg Glu Asn Glu Asp Ser Cys Val Thr Phe Met Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Ile Pro Cys Leu Gly Ser Lys Val Lys Gly Ile Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Ser Lys Val Arg Ser Asp Lys Ser Leu Lys Phe Thr Arg Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg 
                165                 170                 175     


Ala Glu Ala Glu Ala Val Ser Val Leu Val Lys Glu Ala Val Trp Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser 
    210                 215                 220                 


Thr Glu Asp Glu Glu Gln Leu Leu Gln Lys Val Met Asn Leu Trp Glu 
225                 230                 235                 240 


Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Glu 
                245                 250                 255     


Lys Leu Arg Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe Gln 
            260                 265                 270         


Lys Cys Phe Leu Ile Phe Lys Leu Pro Arg Gln Arg Val Asp Ser Asp 
        275                 280                 285             


Gln Ser Ser Trp Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val Asp 
    290                 295                 300                 


Leu Val Leu Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly Trp 
305                 310                 315                 320 


Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr His 
                325                 330                 335     


Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys 
            340                 345                 350         


Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His Leu 
        355                 360                 365             


Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380 


<210>  14
<211>  506
<212>  PRT
<213>  Gallus gallus

<400>  14

Met Glu Arg Ile Arg Pro Pro Thr Val Val Ser Gln Arg Lys Arg Gln 
1               5                   10                  15      


Lys Gly Met Tyr Ser Pro Lys Leu Ser Cys Gly Tyr Glu Ile Lys Phe 
            20                  25                  30          


Asn Lys Leu Val Ile Phe Ile Met Gln Arg Lys Met Gly Met Thr Arg 
        35                  40                  45              


Arg Thr Phe Leu Met Glu Leu Ala Arg Ser Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Ser Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Tyr Pro Glu Val Leu Asp Trp Leu Lys Gly Gln Ala Val Gly Asp Ser 
                85                  90                  95      


Ser Arg Phe Glu Ile Leu Asp Ile Ser Trp Leu Thr Ala Cys Met Glu 
            100                 105                 110         


Met Gly Arg Pro Val Asp Leu Glu Lys Lys Tyr His Leu Val Glu Gln 
        115                 120                 125             


Ala Gly Gln Tyr Pro Thr Leu Lys Thr Pro Glu Ser Glu Val Ser Ser 
    130                 135                 140                 


Phe Thr Ala Ser Lys Val Ser Gln Tyr Ser Cys Gln Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn Lys Lys Phe Thr Asp Ala Phe Glu Ile Met Ala 
                165                 170                 175     


Glu Asn Tyr Glu Phe Lys Glu Asn Glu Ile Phe Cys Leu Glu Phe Leu 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Pro Val Thr Arg Met 
        195                 200                 205             


Lys Asp Ile Gln Gly Leu Pro Cys Met Gly Asp Arg Val Arg Asp Val 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Glu Gly Glu Ser Ser Arg Ala Lys Asp Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Glu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Val Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Leu Arg 
            260                 265                 270         


Thr Val Glu Glu Val Lys Ala Asp Lys Thr Leu Lys Leu Ser Lys Met 
        275                 280                 285             


Gln Arg Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Ser 
    290                 295                 300                 


Lys Ala Glu Ala Asp Ala Val Ser Ser Ile Val Lys Asn Thr Val Cys 
305                 310                 315                 320 


Thr Phe Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Ile Gly His Asp Ile Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Gln Arg Glu Asp Asp Glu Leu Leu His Lys Gly Leu Leu Leu Tyr Cys 
        355                 360                 365             


Asp Ile Ile Glu Ser Thr Phe Val Lys Glu Gln Ile Pro Ser Arg His 
    370                 375                 380                 


Val Asp Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu 
385                 390                 395                 400 


Tyr Gln Pro Arg Val Asp Asn Ser Ser Tyr Asn Met Ser Lys Lys Cys 
                405                 410                 415     


Asp Met Ala Glu Val Lys Asp Trp Lys Ala Ile Arg Val Asp Leu Val 
            420                 425                 430         


Ile Thr Pro Phe Glu Gln Tyr Ala Tyr Ala Leu Leu Gly Trp Thr Gly 
        435                 440                 445             


Ser Arg Gln Phe Gly Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Arg 
    450                 455                 460                 


Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Arg Lys Arg Val 
465                 470                 475                 480 


Phe Leu Lys Ala Gly Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
                485                 490                 495     


Asp Tyr Val Glu Pro Trp Glu Arg Asn Ala 
            500                 505     


<210>  15
<211>  376
<212>  PRT
<213>  Gallus gallus

<400>  15

Gln Tyr Pro Thr Leu Lys Thr Pro Glu Ser Glu Val Ser Ser Phe Thr 
1               5                   10                  15      


Ala Ser Lys Val Ser Gln Tyr Ser Cys Gln Arg Lys Thr Thr Leu Asn 
            20                  25                  30          


Asn Cys Asn Lys Lys Phe Thr Asp Ala Phe Glu Ile Met Ala Glu Asn 
        35                  40                  45              


Tyr Glu Phe Lys Glu Asn Glu Ile Phe Cys Leu Glu Phe Leu Arg Ala 
    50                  55                  60                  


Ala Ser Val Leu Lys Ser Leu Pro Phe Pro Val Thr Arg Met Lys Asp 
65                  70                  75                  80  


Ile Gln Gly Leu Pro Cys Met Gly Asp Arg Val Arg Asp Val Ile Glu 
                85                  90                  95      


Glu Ile Ile Glu Glu Gly Glu Ser Ser Arg Ala Lys Asp Val Leu Asn 
            100                 105                 110         


Asp Glu Arg Tyr Lys Ser Phe Lys Glu Phe Thr Ser Val Phe Gly Val 
        115                 120                 125             


Gly Val Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Leu Arg Thr Val 
    130                 135                 140                 


Glu Glu Val Lys Ala Asp Lys Thr Leu Lys Leu Ser Lys Met Gln Arg 
145                 150                 155                 160 


Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Ser Lys Ala 
                165                 170                 175     


Glu Ala Asp Ala Val Ser Ser Ile Val Lys Asn Thr Val Cys Thr Phe 
            180                 185                 190         


Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe Arg Arg Gly Lys 
        195                 200                 205             


Lys Ile Gly His Asp Ile Asp Phe Leu Ile Thr Ser Pro Gly Gln Arg 
    210                 215                 220                 


Glu Asp Asp Glu Leu Leu His Lys Gly Leu Leu Leu Tyr Cys Asp Ile 
225                 230                 235                 240 


Ile Glu Ser Thr Phe Val Lys Glu Gln Ile Pro Ser Arg His Val Asp 
                245                 250                 255     


Ala Met Asp His Phe Gln Lys Cys Phe Ala Ile Leu Lys Leu Tyr Gln 
            260                 265                 270         


Pro Arg Val Asp Asn Ser Ser Tyr Asn Met Ser Lys Lys Cys Asp Met 
        275                 280                 285             


Ala Glu Val Lys Asp Trp Lys Ala Ile Arg Val Asp Leu Val Ile Thr 
    290                 295                 300                 


Pro Phe Glu Gln Tyr Ala Tyr Ala Leu Leu Gly Trp Thr Gly Ser Arg 
305                 310                 315                 320 


Gln Phe Gly Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Arg Lys Met 
                325                 330                 335     


Met Leu Asp Asn His Ala Leu Tyr Asp Lys Arg Lys Arg Val Phe Leu 
            340                 345                 350         


Lys Ala Gly Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu Asp Tyr 
        355                 360                 365             


Val Glu Pro Trp Glu Arg Asn Ala 
    370                 375     


<210>  16
<211>  518
<212>  PRT
<213>  Monodelphis domestica

<400>  16

Met His Arg Ile Arg Thr Ile Asp Ser Asp Phe Gly Lys Lys Arg Gln 
1               5                   10                  15      


Lys Lys Met Asp Asn His Ile Ser Ser Met Ile Tyr Glu Ile Lys Phe 
            20                  25                  30          


His Glu Phe Val Leu Phe Ile Leu Glu Lys Lys Met Gly Ala Thr Arg 
        35                  40                  45              


Arg Thr Phe Leu Thr Asp Leu Ala Arg Lys Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asn Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Ala Trp Leu Lys Thr His Lys Met Glu Lys Thr 
                85                  90                  95      


Thr Gln Phe Glu Leu Leu Asp Ile Ser Trp Leu Ile Glu Cys Met Lys 
            100                 105                 110         


Val Gly Lys Pro Val Asp Thr Lys Gly Lys Tyr Gln Leu Met Glu Ser 
        115                 120                 125             


Arg Val Asp Ser Ala Asn Pro Asp Pro Thr Ala Gly Thr Leu Asn Ile 
    130                 135                 140                 


Leu Pro Pro Thr Thr Lys Thr Ile Ser Gln Tyr Ala Cys Gln Arg Arg 
145                 150                 155                 160 


Thr Thr Ile Asn Asn His Asn Gln Arg Phe Thr Asp Ala Phe Glu Ile 
                165                 170                 175     


Leu Ala Lys Asn Tyr Glu Phe Lys Glu Asn Asp Asp Thr Cys Leu Thr 
            180                 185                 190         


Phe Met Arg Ala Ile Ser Val Leu Lys Cys Leu Pro Phe Glu Val Val 
        195                 200                 205             


Ser Leu Lys Asp Thr Glu Gly Leu Pro Trp Ile Gly Asp Glu Val Lys 
    210                 215                 220                 


Gly Ile Met Glu Glu Ile Ile Glu Asp Gly Glu Ser Leu Glu Val Gln 
225                 230                 235                 240 


Ala Val Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser 
                245                 250                 255     


Val Phe Gly Val Gly Leu Lys Thr Ala Asp Lys Trp Tyr Arg Met Gly 
            260                 265                 270         


Phe Arg Thr Leu Asn Lys Ile Arg Ser Asp Lys Thr Leu Lys Leu Thr 
        275                 280                 285             


Lys Met Gln Lys Ala Gly Leu Cys Tyr Tyr Glu Asp Leu Ile Asp Cys 
    290                 295                 300                 


Val Ser Lys Ala Glu Ala Asp Ala Val Ser Leu Leu Val Gln Asp Ala 
305                 310                 315                 320 


Val Trp Thr Phe Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe 
                325                 330                 335     


Arg Arg Gly Lys Glu Phe Gly His Asp Val Asp Phe Leu Ile Thr Ser 
            340                 345                 350         


Pro Gly Ala Glu Lys Glu Gln Glu Asp Gln Leu Leu Gln Lys Val Thr 
        355                 360                 365             


Asn Leu Trp Lys Lys Gln Gly Leu Leu Leu Tyr Cys Asp Leu Ile Glu 
    370                 375                 380                 


Ser Thr Phe Glu Asp Leu Lys Leu Pro Ser Arg Lys Ile Asp Ala Leu 
385                 390                 395                 400 


Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Tyr His His Lys 
                405                 410                 415     


Glu Asp Lys Arg Lys Trp Glu Met Pro Thr Gly Ser Asn Glu Ser Glu 
            420                 425                 430         


Ala Lys Ser Trp Lys Ala Ile Arg Val Asp Leu Val Val Cys Pro Tyr 
        435                 440                 445             


Asp Arg Tyr Ala Phe Ala Leu Leu Gly Trp Ser Gly Ser Arg Gln Phe 
    450                 455                 460                 


Glu Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Lys Lys Met Met Leu 
465                 470                 475                 480 


Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Lys Ala 
                485                 490                 495     


Lys Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu Glu Tyr Ile Gln 
            500                 505                 510         


Pro Ser Glu Arg Asn Ala 
        515             


<210>  17
<211>  387
<212>  PRT
<213>  Monodelphis domestica

<400>  17

Ser Ala Asn Pro Asp Pro Thr Ala Gly Thr Leu Asn Ile Leu Pro Pro 
1               5                   10                  15      


Thr Thr Lys Thr Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Ile 
            20                  25                  30          


Asn Asn His Asn Gln Arg Phe Thr Asp Ala Phe Glu Ile Leu Ala Lys 
        35                  40                  45              


Asn Tyr Glu Phe Lys Glu Asn Asp Asp Thr Cys Leu Thr Phe Met Arg 
    50                  55                  60                  


Ala Ile Ser Val Leu Lys Cys Leu Pro Phe Glu Val Val Ser Leu Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Leu Pro Trp Ile Gly Asp Glu Val Lys Gly Ile Met 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Leu Glu Val Gln Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ala Asp Lys Trp Tyr Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Asn Lys Ile Arg Ser Asp Lys Thr Leu Lys Leu Thr Lys Met Gln 
145                 150                 155                 160 


Lys Ala Gly Leu Cys Tyr Tyr Glu Asp Leu Ile Asp Cys Val Ser Lys 
                165                 170                 175     


Ala Glu Ala Asp Ala Val Ser Leu Leu Val Gln Asp Ala Val Trp Thr 
            180                 185                 190         


Phe Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Glu Phe Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ala 
    210                 215                 220                 


Glu Lys Glu Gln Glu Asp Gln Leu Leu Gln Lys Val Thr Asn Leu Trp 
225                 230                 235                 240 


Lys Lys Gln Gly Leu Leu Leu Tyr Cys Asp Leu Ile Glu Ser Thr Phe 
                245                 250                 255     


Glu Asp Leu Lys Leu Pro Ser Arg Lys Ile Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Leu Ile Leu Lys Leu Tyr His His Lys Glu Asp Lys 
        275                 280                 285             


Arg Lys Trp Glu Met Pro Thr Gly Ser Asn Glu Ser Glu Ala Lys Ser 
    290                 295                 300                 


Trp Lys Ala Ile Arg Val Asp Leu Val Val Cys Pro Tyr Asp Arg Tyr 
305                 310                 315                 320 


Ala Phe Ala Leu Leu Gly Trp Ser Gly Ser Arg Gln Phe Glu Arg Asp 
                325                 330                 335     


Leu Arg Arg Tyr Ala Thr His Glu Lys Lys Met Met Leu Asp Asn His 
            340                 345                 350         


Ala Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Lys Ala Lys Ser Glu 
        355                 360                 365             


Glu Glu Ile Phe Ala His Leu Gly Leu Glu Tyr Ile Gln Pro Ser Glu 
    370                 375                 380                 


Arg Asn Ala 
385         


<210>  18
<211>  512
<212>  PRT
<213>  Elephantulus edwardii

<400>  18

Met Asp Pro Leu Gln Met Ala Cys Thr Gly Pro Arg Lys Lys Arg Ala 
1               5                   10                  15      


Arg Gln Met Asp Thr Ser Met Gly Ser Thr Gln Asp Ile Lys Phe Gln 
            20                  25                  30          


Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg Arg 
        35                  40                  45              


Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu Asn 
    50                  55                  60                  


Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser Gly 
65                  70                  75                  80  


Ser Asp Val Leu Glu Trp Leu Gln Val Gln Lys Ile Lys Ala Ser Ser 
                85                  90                  95      


Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Gly Ala 
            100                 105                 110         


Gly Lys Leu Val Glu Ile Thr Gly Lys His Gln Leu Val Ser Ile Met 
        115                 120                 125             


Val Arg Gly Asp Cys Pro Ala Ser His Asp Ser Ser Pro Gln Lys Thr 
    130                 135                 140                 


Glu Ser Ala Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg 
145                 150                 155                 160 


Thr Thr Leu Asn Asn His Asn His Ile Phe Thr Asp Ala Phe Glu Ile 
                165                 170                 175     


Leu Ala Glu Asn Cys Glu Phe Arg Glu Asn Glu Gly Ser Tyr Val Thr 
            180                 185                 190         


Tyr Met Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Ser Ile Ile 
        195                 200                 205             


Ser Met Lys Asp Thr Glu Gly Ile Pro Cys Leu Ala Asp Lys Val Lys 
    210                 215                 220                 


Cys Val Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys 
225                 230                 235                 240 


Ala Val Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser 
                245                 250                 255     


Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Leu Gly 
            260                 265                 270         


Phe Arg Thr Leu Ser Gly Ile Met Asn Asp Lys Thr Leu Lys Leu Thr 
        275                 280                 285             


His Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys 
    290                 295                 300                 


Val Thr Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala 
305                 310                 315                 320 


Val Trp Ala Phe Leu Pro Asp Ala Ile Val Thr Met Thr Gly Gly Phe 
                325                 330                 335     


Arg Arg Gly Lys Lys Val Gly His Asp Val Asp Phe Leu Ile Thr Ser 
            340                 345                 350         


Pro Glu Ala Thr Glu Glu Gln Glu Gln Gln Leu Leu His Lys Val Ile 
        355                 360                 365             


Thr Phe Trp Glu Lys Glu Gly Leu Leu Leu Tyr Cys Asp Leu Tyr Glu 
    370                 375                 380                 


Ser Thr Phe Glu Lys Leu Lys Met Pro Ser Arg Lys Val Asp Ala Leu 
385                 390                 395                 400 


Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His Arg Glu Cys 
                405                 410                 415     


Val Asp Asp Gly Thr Ser Ser Gln Leu Gln Gly Lys Thr Trp Lys Ala 
            420                 425                 430         


Ile Arg Val Asp Leu Val Val Cys Pro Tyr Glu Cys Arg Ala Phe Ala 
        435                 440                 445             


Leu Leu Gly Trp Thr Gly Ser Pro Gln Phe Glu Arg Asp Leu Arg Arg 
    450                 455                 460                 


Tyr Ala Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr 
465                 470                 475                 480 


Asp Lys Thr Lys Arg Lys Phe Leu Ser Ala Asp Ser Glu Glu Asp Ile 
                485                 490                 495     


Phe Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510         


<210>  19
<211>  381
<212>  PRT
<213>  Elephantulus edwardii

<400>  19

Asp Cys Pro Ala Ser His Asp Ser Ser Pro Gln Lys Thr Glu Ser Ala 
1               5                   10                  15      


Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn His Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala Glu 
        35                  40                  45              


Asn Cys Glu Phe Arg Glu Asn Glu Gly Ser Tyr Val Thr Tyr Met Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Ser Ile Ile Ser Met Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Ile Pro Cys Leu Ala Asp Lys Val Lys Cys Val Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Leu Gly Phe Arg Thr 
    130                 135                 140                 


Leu Ser Gly Ile Met Asn Asp Lys Thr Leu Lys Leu Thr His Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg 
                165                 170                 175     


Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Trp Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Ile Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Val Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Ala 
    210                 215                 220                 


Thr Glu Glu Gln Glu Gln Gln Leu Leu His Lys Val Ile Thr Phe Trp 
225                 230                 235                 240 


Glu Lys Glu Gly Leu Leu Leu Tyr Cys Asp Leu Tyr Glu Ser Thr Phe 
                245                 250                 255     


Glu Lys Leu Lys Met Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Leu Ile Leu Lys Leu His Arg Glu Cys Val Asp Asp 
        275                 280                 285             


Gly Thr Ser Ser Gln Leu Gln Gly Lys Thr Trp Lys Ala Ile Arg Val 
    290                 295                 300                 


Asp Leu Val Val Cys Pro Tyr Glu Cys Arg Ala Phe Ala Leu Leu Gly 
305                 310                 315                 320 


Trp Thr Gly Ser Pro Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr 
                325                 330                 335     


His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
            340                 345                 350         


Lys Arg Lys Phe Leu Ser Ala Asp Ser Glu Glu Asp Ile Phe Ala His 
        355                 360                 365             


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380     


<210>  20
<211>  506
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Python bivittatus

<400>  20

Met Asn Lys Met Lys Thr Ser Asp Phe Ser Pro Met Arg Lys Arg Gln 
1               5                   10                  15      


Lys Arg Met Gln Ile Ala Ala Pro Leu Ser Ser Tyr Lys Ile Glu Phe 
            20                  25                  30          


Lys Asp Ile Ile Ile Phe Ile Val Glu Arg Lys Met Gly Met Thr Arg 
        35                  40                  45              


Arg Met Phe Leu Met Asp Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Leu Val Thr His Val Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Cys Ser Glu Ile Leu Lys Trp Leu Gln Lys His Asn Val Glu Asp Ser 
                85                  90                  95      


Ser Arg Phe Arg Ile Leu Asp Ile Arg Trp Leu Thr Ala Cys Met Glu 
            100                 105                 110         


Val Gly Arg Pro Val Asp Ser Glu Lys Tyr Gln Leu Pro Glu Asp Glu 
        115                 120                 125             


Asp Arg Ser Val Thr Ser Asp Leu Asp Arg Asp Ser Ile Ser Glu Tyr 
    130                 135                 140                 


Ala Cys Gln Arg Arg Thr Thr Leu Lys Asn Tyr Asn Gln Lys Phe Thr 
145                 150                 155                 160 


Asp Ala Phe Glu Ile Leu Ala Glu Asn Tyr Glu Phe Asn Glu Asn Lys 
                165                 170                 175     


Gly Phe Cys Thr Ala Phe Arg Arg Ala Ala Ser Val Leu Lys Cys Leu 
            180                 185                 190         


Pro Phe Thr Ile Val Gln Val His Asp Ile Glu Gly Val Pro Trp Met 
        195                 200                 205             


Gly Lys Gln Val Lys Gly Ile Ile Glu Asp Ile Ile Glu Glu Gly Glu 
    210                 215                 220                 


Ser Ser Lys Val Lys Ala Val Leu Asp Asn Glu Asn Tyr Arg Ser Val 
225                 230                 235                 240 


Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu Lys Thr Ser Asp Lys 
                245                 250                 255     


Trp Tyr Arg Met Gly Leu Arg Thr Leu Glu Glu Val Lys Arg Asp Lys 
            260                 265                 270         


Asn Leu Lys Leu Thr Arg Met Gln Lys Ala Gly Phe Leu His Tyr Asp 
        275                 280                 285             


Asp Leu Thr Ser Cys Val Ser Lys Ala Glu Ala Asp Ala Ala Ser Leu 
    290                 295                 300                 


Ile Val Gln Asp Val Val Trp Lys Ile Val Pro Asn Ala Ile Val Thr 
305                 310                 315                 320 


Ile Ala Gly Gly Phe Arg Arg Gly Lys Gln Thr Gly His Asp Val Asp 
                325                 330                 335     


Phe Leu Ile Thr Val Pro Gly Ser Lys Gln Glu Glu Glu Glu Leu Leu 
            340                 345                 350         


His Thr Val Ile Asp Ile Trp Lys Lys Gln Glu Leu Leu Leu Tyr Tyr 
        355                 360                 365             


Asp Leu Ile Glu Ser Thr Phe Glu Asp Thr Lys Leu Pro Ser Arg Lys 
    370                 375                 380                 


Val Asp Ala Leu Asp His Phe Gln Lys Cys Phe Ala Ile Leu Lys Val 
385                 390                 395                 400 


His Lys Glu Arg Glu Asp Lys Gly Asn Ser Ile Arg Ser Lys Ala Phe 
                405                 410                 415     


Ser Glu Glu Glu Ile Lys Asp Trp Lys Ala Ile Arg Val Asp Leu Val 
            420                 425                 430         


Val Val Pro Phe Glu Gln Tyr Ala Phe Ala Leu Leu Gly Trp Thr Gly 
        435                 440                 445             


Ser Thr Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Lys 
    450                 455                 460                 


Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
465                 470                 475                 480 


Phe Leu Asn Ala Ala Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
                485                 490                 495     


Asp Tyr Leu Glu Pro Trp Glu Arg Asn Ala 
            500                 505     


<210>  21
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Python bivittatus

<400>  21

Glu Lys Tyr Gln Leu Pro Glu Asp Glu Asp Arg Ser Val Thr Ser Asp 
1               5                   10                  15      


Leu Asp Arg Asp Ser Ile Ser Glu Tyr Ala Cys Gln Arg Arg Thr Thr 
            20                  25                  30          


Leu Lys Asn Tyr Asn Gln Lys Phe Thr Asp Ala Phe Glu Ile Leu Ala 
        35                  40                  45              


Glu Asn Tyr Glu Phe Asn Glu Asn Lys Gly Phe Cys Thr Ala Phe Arg 
    50                  55                  60                  


Arg Ala Ala Ser Val Leu Lys Cys Leu Pro Phe Thr Ile Val Gln Val 
65                  70                  75                  80  


His Asp Ile Glu Gly Val Pro Trp Met Gly Lys Gln Val Lys Gly Ile 
                85                  90                  95      


Ile Glu Asp Ile Ile Glu Glu Gly Glu Ser Ser Lys Val Lys Ala Val 
            100                 105                 110         


Leu Asp Asn Glu Asn Tyr Arg Ser Val Lys Leu Phe Thr Ser Val Phe 
        115                 120                 125             


Gly Val Gly Leu Lys Thr Ser Asp Lys Trp Tyr Arg Met Gly Leu Arg 
    130                 135                 140                 


Thr Leu Glu Glu Val Lys Arg Asp Lys Asn Leu Lys Leu Thr Arg Met 
145                 150                 155                 160 


Gln Lys Ala Gly Phe Leu His Tyr Asp Asp Leu Thr Ser Cys Val Ser 
                165                 170                 175     


Lys Ala Glu Ala Asp Ala Ala Ser Leu Ile Val Gln Asp Val Val Trp 
            180                 185                 190         


Lys Ile Val Pro Asn Ala Ile Val Thr Ile Ala Gly Gly Phe Arg Arg 
        195                 200                 205             


Gly Lys Gln Thr Gly His Asp Val Asp Phe Leu Ile Thr Val Pro Gly 
    210                 215                 220                 


Ser Lys Gln Glu Glu Glu Glu Leu Leu His Thr Val Ile Asp Ile Trp 
225                 230                 235                 240 


Lys Lys Gln Glu Leu Leu Leu Tyr Tyr Asp Leu Ile Glu Ser Thr Phe 
                245                 250                 255     


Glu Asp Thr Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Ala Ile Leu Lys Val His Lys Glu Arg Glu Asp Lys 
        275                 280                 285             


Gly Asn Ser Ile Arg Ser Lys Ala Phe Ser Glu Glu Glu Ile Lys Asp 
    290                 295                 300                 


Trp Lys Ala Ile Arg Val Asp Leu Val Val Val Pro Phe Glu Gln Tyr 
305                 310                 315                 320 


Ala Phe Ala Leu Leu Gly Trp Thr Gly Ser Thr Gln Phe Glu Arg Asp 
                325                 330                 335     


Leu Arg Arg Tyr Ala Thr His Glu Lys Lys Met Met Leu Asp Asn His 
            340                 345                 350         


Ala Leu Tyr Asp Lys Thr Lys Lys Ile Phe Leu Asn Ala Ala Ser Glu 
        355                 360                 365             


Glu Glu Ile Phe Ala His Leu Gly Leu Asp Tyr Leu Glu Pro Trp Glu 
    370                 375                 380                 


Arg Asn Ala 
385         


<210>  22
<211>  490
<212>  PRT
<213>  Canis lupus

<400>  22

Met Gly Ala Glu Ala Gly Thr Trp Arg Asp Thr Gly Gly Lys Phe Leu 
1               5                   10                  15      


Leu Leu Ala Thr Glu Pro Glu Arg Lys Phe Arg Ala Ser Asp Ala Cys 
            20                  25                  30          


Cys Gln Gly Pro Ser Pro Ala Gly Gln Ala Leu Glu Glu Thr Gly Ala 
        35                  40                  45              


Cys Asp Ser Ile Thr His Ile Val Ala Glu Asn Asn Ser Gly Ser Asp 
    50                  55                  60                  


Val Leu Glu Trp Leu Gln Val Gln Asn Ile Lys Ala Ser Ser Gln Leu 
65                  70                  75                  80  


Glu Leu Leu Asp Ile Ser Trp Leu Ile Glu Ser Met Gly Ala Gly Lys 
                85                  90                  95      


Pro Val Glu Met Thr Gly Lys His Gln Leu Met Arg Arg Asp Tyr Thr 
            100                 105                 110         


Ala Ser Pro Asn Pro Glu Leu Gln Lys Thr Leu Pro Val Ala Val Lys 
        115                 120                 125             


Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu Asn Asn Tyr 
    130                 135                 140                 


Asn Asn Val Phe Thr Asp Ala Phe Glu Val Leu Ala Glu Asn Tyr Glu 
145                 150                 155                 160 


Phe Arg Glu Asn Glu Val Phe Ser Leu Thr Phe Met Arg Ala Ala Ser 
                165                 170                 175     


Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys Asp Thr Glu 
            180                 185                 190         


Gly Ile Pro Cys Leu Gly Asp Gln Val Lys Cys Ile Ile Glu Glu Ile 
        195                 200                 205             


Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu Asn Asp Glu 
    210                 215                 220                 


Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly Val Gly Leu 
225                 230                 235                 240 


Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Thr Leu Ser Lys 
                245                 250                 255     


Ile Lys Ser Asp Lys Ser Leu Lys Phe Thr Pro Met Gln Lys Ala Gly 
            260                 265                 270         


Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg Ala Glu Ala 
        275                 280                 285             


Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Gly Ala Phe Leu Pro 
    290                 295                 300                 


Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg Gly Lys Lys Met 
305                 310                 315                 320 


Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser Thr Asp Glu 
                325                 330                 335     


Asp Glu Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp Glu Arg Lys 
            340                 345                 350         


Gly Leu Leu Leu Tyr Cys Asp Leu Val Glu Ser Thr Phe Glu Lys Leu 
        355                 360                 365             


Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe Gln Lys Cys 
    370                 375                 380                 


Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Gly Gly Lys Cys 
385                 390                 395                 400 


Ser Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val Asp Leu Val 
                405                 410                 415     


Met Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly Trp Thr Gly 
            420                 425                 430         


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Ser His Glu Arg 
        435                 440                 445             


Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
    450                 455                 460                 


Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His Leu Gly Leu 
465                 470                 475                 480 


Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
                485                 490 


<210>  23
<211>  381
<212>  PRT
<213>  Canis lupus

<400>  23

Asp Tyr Thr Ala Ser Pro Asn Pro Glu Leu Gln Lys Thr Leu Pro Val 
1               5                   10                  15      


Ala Val Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn Tyr Asn Asn Val Phe Thr Asp Ala Phe Glu Val Leu Ala Glu 
        35                  40                  45              


Asn Tyr Glu Phe Arg Glu Asn Glu Val Phe Ser Leu Thr Phe Met Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys 
65                  70                  75                  80  


Asp Thr Glu Gly Ile Pro Cys Leu Gly Asp Gln Val Lys Cys Ile Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Ser Lys Ile Lys Ser Asp Lys Ser Leu Lys Phe Thr Pro Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr Arg 
                165                 170                 175     


Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Gly Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Phe Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Met Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser 
    210                 215                 220                 


Thr Asp Glu Asp Glu Glu Gln Leu Leu Pro Lys Val Ile Asn Leu Trp 
225                 230                 235                 240 


Glu Arg Lys Gly Leu Leu Leu Tyr Cys Asp Leu Val Glu Ser Thr Phe 
                245                 250                 255     


Glu Lys Leu Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Gly 
        275                 280                 285             


Gly Lys Cys Ser Gln Gln Glu Gly Lys Thr Trp Lys Ala Ile Arg Val 
    290                 295                 300                 


Asp Leu Val Met Cys Pro Tyr Glu Arg Arg Ala Phe Ala Leu Leu Gly 
305                 310                 315                 320 


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Ser 
                325                 330                 335     


His Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
            340                 345                 350         


Lys Lys Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe Ala His 
        355                 360                 365             


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380     


<210>  24
<211>  512
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Condylura cristata

<400>  24

Met Asp Pro Leu Gln Met Ala Cys Thr Gly Pro Arg Lys Lys Arg Ala 
1               5                   10                  15      


Arg Gln Met Asp Thr Ser Met Gly Ser Thr Gln Asp Ile Lys Phe Gln 
            20                  25                  30          


Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr Arg Arg 
        35                  40                  45              


Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu Asn 
    50                  55                  60                  


Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser Gly 
65                  70                  75                  80  


Ser Asp Val Leu Glu Trp Leu Gln Val Gln Lys Ile Lys Ala Ser Ser 
                85                  90                  95      


Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Gly Ala 
            100                 105                 110         


Gly Lys Leu Val Glu Ile Thr Gly Lys His Gln Leu Val Ser Ile Met 
        115                 120                 125             


Val Arg Gly Asp Cys Pro Ala Ser His Asp Ser Ser Pro Gln Lys Thr 
    130                 135                 140                 


Glu Ser Ala Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg 
145                 150                 155                 160 


Thr Thr Leu Asn Asn His Asn His Ile Phe Thr Asp Ala Phe Glu Ile 
                165                 170                 175     


Leu Ala Glu Asn Cys Glu Phe Arg Glu Asn Glu Gly Ser Tyr Val Thr 
            180                 185                 190         


Tyr Met Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Ser Ile Ile 
        195                 200                 205             


Ser Met Lys Asp Thr Glu Gly Ile Pro Cys Leu Ala Asp Lys Val Lys 
    210                 215                 220                 


Cys Val Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys 
225                 230                 235                 240 


Ala Val Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser 
                245                 250                 255     


Val Phe Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Leu Gly 
            260                 265                 270         


Phe Arg Thr Leu Ser Gly Ile Met Asn Asp Lys Thr Leu Lys Leu Thr 
        275                 280                 285             


His Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys 
    290                 295                 300                 


Val Thr Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala 
305                 310                 315                 320 


Val Trp Ala Phe Leu Pro Asp Ala Ile Val Thr Met Thr Gly Gly Phe 
                325                 330                 335     


Arg Arg Gly Lys Lys Val Gly His Asp Val Asp Phe Leu Ile Thr Ser 
            340                 345                 350         


Pro Glu Ala Thr Glu Glu Gln Glu Gln Gln Leu Leu His Lys Val Ile 
        355                 360                 365             


Thr Phe Trp Glu Lys Glu Gly Leu Leu Leu Tyr Cys Asp Leu Tyr Glu 
    370                 375                 380                 


Ser Thr Phe Glu Lys Leu Lys Met Pro Ser Arg Lys Val Asp Ala Leu 
385                 390                 395                 400 


Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His Arg Glu Cys 
                405                 410                 415     


Val Asp Asp Gly Thr Ser Ser Gln Leu Gln Gly Lys Thr Trp Lys Ala 
            420                 425                 430         


Ile Arg Val Asp Leu Val Val Cys Pro Tyr Glu Cys Arg Ala Phe Ala 
        435                 440                 445             


Leu Leu Gly Trp Thr Gly Ser Pro Gln Phe Glu Arg Asp Leu Arg Arg 
    450                 455                 460                 


Tyr Ala Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr 
465                 470                 475                 480 


Asp Lys Thr Lys Arg Lys Phe Leu Ser Ala Asp Ser Glu Glu Asp Ile 
                485                 490                 495     


Phe Ala His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510         


<210>  25
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Condylura cristata

<400>  25

Gly Asp Cys Pro Ala Ser His Asp Ser Ser Pro Gln Lys Thr Glu Ser 
1               5                   10                  15      


Ala Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
            20                  25                  30          


Leu Asn Asn His Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala 
        35                  40                  45              


Glu Asn Cys Glu Phe Arg Glu Asn Glu Gly Ser Tyr Val Thr Tyr Met 
    50                  55                  60                  


Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Ser Ile Ile Ser Met 
65                  70                  75                  80  


Lys Asp Thr Glu Gly Ile Pro Cys Leu Ala Asp Lys Val Lys Cys Val 
                85                  90                  95      


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Val 
            100                 105                 110         


Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe 
        115                 120                 125             


Gly Val Gly Leu Lys Thr Ala Glu Lys Trp Phe Arg Leu Gly Phe Arg 
    130                 135                 140                 


Thr Leu Ser Gly Ile Met Asn Asp Lys Thr Leu Lys Leu Thr His Met 
145                 150                 155                 160 


Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Thr 
                165                 170                 175     


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Trp 
            180                 185                 190         


Ala Phe Leu Pro Asp Ala Ile Val Thr Met Thr Gly Gly Phe Arg Arg 
        195                 200                 205             


Gly Lys Lys Val Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu 
    210                 215                 220                 


Ala Thr Glu Glu Gln Glu Gln Gln Leu Leu His Lys Val Ile Thr Phe 
225                 230                 235                 240 


Trp Glu Lys Glu Gly Leu Leu Leu Tyr Cys Asp Leu Tyr Glu Ser Thr 
                245                 250                 255     


Phe Glu Lys Leu Lys Met Pro Ser Arg Lys Val Asp Ala Leu Asp His 
            260                 265                 270         


Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His Arg Glu Cys Val Asp 
        275                 280                 285             


Asp Gly Thr Ser Ser Gln Leu Gln Gly Lys Thr Trp Lys Ala Ile Arg 
    290                 295                 300                 


Val Asp Leu Val Val Cys Pro Tyr Glu Cys Arg Ala Phe Ala Leu Leu 
305                 310                 315                 320 


Gly Trp Thr Gly Ser Pro Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
                325                 330                 335     


Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys 
            340                 345                 350         


Thr Lys Arg Lys Phe Leu Ser Ala Asp Ser Glu Glu Asp Ile Phe Ala 
        355                 360                 365             


His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380         


<210>  26
<211>  508
<212>  PRT
<213>  Ochotona princeps

<400>  26

Met Asp Ser Leu Gln Thr Gly His Leu Gly Pro Arg Lys Lys Arg Ser 
1               5                   10                  15      


Arg Gln Thr Asp Ala Ala Arg Thr Ser Ile Pro Gln Glu Val Lys Phe 
            20                  25                  30          


Gln Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Ser Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Ser Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Leu Glu Trp Leu Gln Val Gln Lys Leu Lys Asp Ser 
                85                  90                  95      


Ser Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Arg 
            100                 105                 110         


Ala Gly Lys Pro Val Ala Thr Thr Gly Lys His Gln Leu Val Met Arg 
        115                 120                 125             


Glu Glu Tyr Ser Ala Asn Pro Ser Pro Gly Pro Gln Ala Thr Pro Ala 
    130                 135                 140                 


Val Tyr Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu Asn 
145                 150                 155                 160 


Asn His Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala Glu Asn 
                165                 170                 175     


Tyr Glu Phe Lys Glu Asn Glu Gly Cys Tyr Val Thr Tyr Met Arg Ala 
            180                 185                 190         


Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Val Ser Met Lys Asp 
        195                 200                 205             


Thr Glu Gly Ile Pro Cys Leu Glu Asp Lys Val Lys Ser Ile Met Glu 
    210                 215                 220                 


Glu Ile Ile Glu Glu Gly Glu Ser Ser Glu Val Lys Ala Val Leu Ser 
225                 230                 235                 240 


Asp Glu Arg Tyr Gln Cys Phe Lys Leu Phe Thr Ser Val Phe Gly Val 
                245                 250                 255     


Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Ser Leu 
            260                 265                 270         


Ser Asn Ile Arg Leu Asp Lys Ser Leu Lys Phe Thr Gln Met Gln Lys 
        275                 280                 285             


Ala Gly Phe Arg Tyr Tyr Glu Asp Ile Val Ser Cys Val Thr Arg Ala 
    290                 295                 300                 


Glu Ala Glu Ala Val Asp Val Leu Val Asn Glu Ala Val Arg Ala Phe 
305                 310                 315                 320 


Leu Pro Asp Ala Phe Ile Thr Met Thr Gly Gly Phe Arg Arg Gly Lys 
                325                 330                 335     


Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Leu Thr 
            340                 345                 350         


Glu Glu Asp Glu Gln Gln Leu Leu His Lys Val Met Asn Leu Trp Glu 
        355                 360                 365             


Lys Lys Gly Leu Leu Leu Tyr His Asp Leu Val Glu Ser Thr Phe Glu 
    370                 375                 380                 


Lys Leu Lys Gln Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe Gln 
385                 390                 395                 400 


Lys Cys Phe Leu Ile Phe Lys Leu Tyr His Glu Arg Val Gly Gly Asp 
                405                 410                 415     


Arg Cys Arg Gln Pro Glu Gly Lys Asp Trp Lys Ala Ile Arg Val Asp 
            420                 425                 430         


Leu Val Met Cys Pro Tyr Glu Cys His Ala Phe Ala Leu Leu Gly Trp 
        435                 440                 445             


Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Ser His 
    450                 455                 460                 


Glu Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys 
465                 470                 475                 480 


Arg Val Phe Leu Gln Ala Glu Asn Glu Glu Glu Ile Phe Ala His Leu 
                485                 490                 495     


Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505             


<210>  27
<211>  379
<212>  PRT
<213>  Ochotona princeps

<400>  27

Glu Tyr Ser Ala Asn Pro Ser Pro Gly Pro Gln Ala Thr Pro Ala Val 
1               5                   10                  15      


Tyr Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu Asn Asn 
            20                  25                  30          


His Asn His Ile Phe Thr Asp Ala Phe Glu Ile Leu Ala Glu Asn Tyr 
        35                  40                  45              


Glu Phe Lys Glu Asn Glu Gly Cys Tyr Val Thr Tyr Met Arg Ala Ala 
    50                  55                  60                  


Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Val Ser Met Lys Asp Thr 
65                  70                  75                  80  


Glu Gly Ile Pro Cys Leu Glu Asp Lys Val Lys Ser Ile Met Glu Glu 
                85                  90                  95      


Ile Ile Glu Glu Gly Glu Ser Ser Glu Val Lys Ala Val Leu Ser Asp 
            100                 105                 110         


Glu Arg Tyr Gln Cys Phe Lys Leu Phe Thr Ser Val Phe Gly Val Gly 
        115                 120                 125             


Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Ser Leu Ser 
    130                 135                 140                 


Asn Ile Arg Leu Asp Lys Ser Leu Lys Phe Thr Gln Met Gln Lys Ala 
145                 150                 155                 160 


Gly Phe Arg Tyr Tyr Glu Asp Ile Val Ser Cys Val Thr Arg Ala Glu 
                165                 170                 175     


Ala Glu Ala Val Asp Val Leu Val Asn Glu Ala Val Arg Ala Phe Leu 
            180                 185                 190         


Pro Asp Ala Phe Ile Thr Met Thr Gly Gly Phe Arg Arg Gly Lys Lys 
        195                 200                 205             


Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Glu Leu Thr Glu 
    210                 215                 220                 


Glu Asp Glu Gln Gln Leu Leu His Lys Val Met Asn Leu Trp Glu Lys 
225                 230                 235                 240 


Lys Gly Leu Leu Leu Tyr His Asp Leu Val Glu Ser Thr Phe Glu Lys 
                245                 250                 255     


Leu Lys Gln Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe Gln Lys 
            260                 265                 270         


Cys Phe Leu Ile Phe Lys Leu Tyr His Glu Arg Val Gly Gly Asp Arg 
        275                 280                 285             


Cys Arg Gln Pro Glu Gly Lys Asp Trp Lys Ala Ile Arg Val Asp Leu 
    290                 295                 300                 


Val Met Cys Pro Tyr Glu Cys His Ala Phe Ala Leu Leu Gly Trp Thr 
305                 310                 315                 320 


Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Ser His Glu 
                325                 330                 335     


Arg Lys Met Ile Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Arg 
            340                 345                 350         


Val Phe Leu Gln Ala Glu Asn Glu Glu Glu Ile Phe Ala His Leu Gly 
        355                 360                 365             


Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 


<210>  28
<211>  516
<212>  PRT
<213>  Erinaceus europaeus

<400>  28

Met Asp Ala Leu Pro Val Val His Ser Ser Pro Arg Lys Lys Arg Ser 
1               5                   10                  15      


Arg Leu Met Gly Ala Ser Val Ala Tyr Pro Pro Tyr Asp Ile Lys Phe 
            20                  25                  30          


His Asn Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Ser Ser Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asp Glu Leu Ser Asp Ser Ile Thr His Ile Val Ala Glu Asn Asn Thr 
65                  70                  75                  80  


Gly Ser Glu Val Leu Glu Trp Leu Gln Val Gln Asp Ile Lys Ile Ser 
                85                  90                  95      


Ser Gln Leu Glu Leu Leu Asp Val Ser Trp Leu Val Glu Cys Met Arg 
            100                 105                 110         


Ala Gly Asn Pro Val Val Ile Thr Gly Lys His Gln Leu Val Ser Tyr 
        115                 120                 125             


Thr Val Lys Ser Asp Ala Ser Phe Gly Ser Asn Pro Gly Ser Gln Asn 
    130                 135                 140                 


Thr Pro Pro Leu Ala Ile Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg 
145                 150                 155                 160 


Arg Thr Ser Leu Asn Asn Cys Asn His Ile Phe Thr Asp Ala Leu Asp 
                165                 170                 175     


Ile Leu Ala Glu Asn His Glu Phe Arg Glu Asn Glu Val Ser Cys Val 
            180                 185                 190         


Ala Phe Met Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile 
        195                 200                 205             


Ile Ser Met Lys Asp Thr Lys Gly Ile Pro Cys Leu Gly Asp Lys Ala 
    210                 215                 220                 


Lys Cys Val Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val 
225                 230                 235                 240 


Lys Ala Ile Leu Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr 
                245                 250                 255     


Ser Val Phe Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met 
            260                 265                 270         


Gly Phe Arg Thr Leu Asn Lys Ile Met Ser Asp Lys Thr Leu Lys Leu 
        275                 280                 285             


Thr Arg Met Gln Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser 
    290                 295                 300                 


Cys Val Ala Lys Ala Glu Ala Asp Ala Val Ser Val Leu Val Gln Glu 
305                 310                 315                 320 


Ala Val Trp Ala Phe Leu Pro Asp Ala Met Val Thr Met Thr Gly Gly 
                325                 330                 335     


Phe Arg Arg Gly Lys Lys Leu Gly His Asp Val Asp Phe Leu Ile Thr 
            340                 345                 350         


Ser Pro Gly Ala Thr Glu Glu Glu Glu Gln Gln Leu Leu Pro Lys Val 
        355                 360                 365             


Ile Asn Phe Trp Glu Arg Lys Gly Leu Leu Leu Tyr His Asp Leu Val 
    370                 375                 380                 


Glu Ser Thr Phe Glu Lys Leu Lys Leu Pro Ser Arg Lys Val Asp Ala 
385                 390                 395                 400 


Leu Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu His Leu Gln 
                405                 410                 415     


His Val Asn Gly Val Gly Asn Ser Lys Thr Gly Gln Gln Glu Gly Lys 
            420                 425                 430         


Asn Trp Lys Ala Ile Arg Val Asp Leu Val Met Cys Pro Tyr Glu Arg 
        435                 440                 445             


Arg Ala Phe Ala Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg 
    450                 455                 460                 


Asp Leu Arg Arg Phe Ala Thr His Glu Arg Lys Met Met Leu Asp Asn 
465                 470                 475                 480 


His Ala Leu Tyr Asp Lys Thr Lys Arg Ile Phe Leu Lys Ala Glu Ser 
                485                 490                 495     


Glu Glu Glu Ile Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp 
            500                 505                 510         


Glu Arg Asn Ala 
        515     


<210>  29
<211>  384
<212>  PRT
<213>  Erinaceus europaeus

<400>  29

Asp Ala Ser Phe Gly Ser Asn Pro Gly Ser Gln Asn Thr Pro Pro Leu 
1               5                   10                  15      


Ala Ile Lys Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Ser Leu 
            20                  25                  30          


Asn Asn Cys Asn His Ile Phe Thr Asp Ala Leu Asp Ile Leu Ala Glu 
        35                  40                  45              


Asn His Glu Phe Arg Glu Asn Glu Val Ser Cys Val Ala Phe Met Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Thr Ile Ile Ser Met Lys 
65                  70                  75                  80  


Asp Thr Lys Gly Ile Pro Cys Leu Gly Asp Lys Ala Lys Cys Val Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala Ile Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Gln Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Asn Lys Ile Met Ser Asp Lys Thr Leu Lys Leu Thr Arg Met Gln 
145                 150                 155                 160 


Lys Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Ala Lys 
                165                 170                 175     


Ala Glu Ala Asp Ala Val Ser Val Leu Val Gln Glu Ala Val Trp Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Met Val Thr Met Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Leu Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ala 
    210                 215                 220                 


Thr Glu Glu Glu Glu Gln Gln Leu Leu Pro Lys Val Ile Asn Phe Trp 
225                 230                 235                 240 


Glu Arg Lys Gly Leu Leu Leu Tyr His Asp Leu Val Glu Ser Thr Phe 
                245                 250                 255     


Glu Lys Leu Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Gln Lys Cys Phe Leu Ile Leu Lys Leu His Leu Gln His Val Asn Gly 
        275                 280                 285             


Val Gly Asn Ser Lys Thr Gly Gln Gln Glu Gly Lys Asn Trp Lys Ala 
    290                 295                 300                 


Ile Arg Val Asp Leu Val Met Cys Pro Tyr Glu Arg Arg Ala Phe Ala 
305                 310                 315                 320 


Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg 
                325                 330                 335     


Phe Ala Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr 
            340                 345                 350         


Asp Lys Thr Lys Arg Ile Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile 
        355                 360                 365             


Phe Ala His Leu Gly Leu Asp Tyr Ile Asp Pro Trp Glu Arg Asn Ala 
    370                 375                 380                 


<210>  30
<211>  510
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tupaia chinensis


<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<400>  30

Met Asp Leu Leu Arg Met Ala Pro Leu Ser Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Met Gly Ser Ser Met Ala Ser Ala Pro His Asp Ile Lys Phe 
            20                  25                  30          


Gln Gly Val Val Leu Tyr Ile Leu Glu Lys Lys Met Gly Thr Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Met Ser Leu Ser His Gln Val Trp Asp Xaa Asn Cys 
65                  70                  75                  80  


Gly Xaa Asp Val Arg Glu Trp Leu Gln Val Gln Lys Val Lys Ala Ser 
                85                  90                  95      


Ser Gln Pro Glu Leu Leu Asp Val Ser Trp Leu Val Glu Cys Met Arg 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Ala Thr Gly Lys His Gln Leu Leu Val Lys 
        115                 120                 125             


Ser Asp His Ser Thr Ser Pro Ser Pro Gly Pro Gln Lys Thr Pro Ala 
    130                 135                 140                 


Leu Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr 
145                 150                 155                 160 


Leu Asn Asn Cys Asn Arg Val Phe Thr Asp Ala Phe Glu Thr Leu Ala 
                165                 170                 175     


Glu Asn Tyr Glu Phe Arg Glu Asn Glu Asp Ser Ser Val Ile Phe Leu 
            180                 185                 190         


Arg Ala Ala Ser Val Leu Arg Ser Leu Pro Phe Thr Ile Thr Ser Met 
        195                 200                 205             


Arg Asp Thr Glu Gly Leu Pro Cys Leu Gly Asp Lys Val Lys Cys Val 
    210                 215                 220                 


Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Asn Ala Val 
225                 230                 235                 240 


Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe 
                245                 250                 255     


Gly Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg 
            260                 265                 270         


Thr Leu Ser Arg Val Arg Ser Asp Lys Ser Leu His Leu Thr Arg Met 
        275                 280                 285             


Gln Gln Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Ala Ser Cys Val Thr 
    290                 295                 300                 


Arg Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Gly 
305                 310                 315                 320 


Ala Phe Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe Arg Arg 
                325                 330                 335     


Gly Lys Lys Thr Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly 
            340                 345                 350         


Ser Thr Glu Glu Lys Glu Glu Glu Leu Leu Gln Lys Val Leu Asn Leu 
        355                 360                 365             


Trp Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr 
    370                 375                 380                 


Phe Glu Lys Leu Lys Thr Pro Ser Arg Lys Val Asp Ala Leu Asp His 
385                 390                 395                 400 


Phe Pro Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp 
                405                 410                 415     


Gly Asp Lys Pro Ser Gln Gln Glu Gly Lys Ser Trp Lys Ala Ile Arg 
            420                 425                 430         


Val Asp Leu Val Met Cys Pro Tyr Glu Arg His Ala Phe Ala Leu Leu 
        435                 440                 445             


Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala 
    450                 455                 460                 


Thr His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys 
465                 470                 475                 480 


Thr Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Asp Ile Phe Ala 
                485                 490                 495     


His Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
            500                 505                 510 


<210>  31
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tupaia chinensis

<400>  31

Asp His Ser Thr Ser Pro Ser Pro Gly Pro Gln Lys Thr Pro Ala Leu 
1               5                   10                  15      


Ala Val Gln Lys Ile Ser Gln Tyr Ala Cys Gln Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn Cys Asn Arg Val Phe Thr Asp Ala Phe Glu Thr Leu Ala Glu 
        35                  40                  45              


Asn Tyr Glu Phe Arg Glu Asn Glu Asp Ser Ser Val Ile Phe Leu Arg 
    50                  55                  60                  


Ala Ala Ser Val Leu Arg Ser Leu Pro Phe Thr Ile Thr Ser Met Arg 
65                  70                  75                  80  


Asp Thr Glu Gly Leu Pro Cys Leu Gly Asp Lys Val Lys Cys Val Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Asn Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val Phe Gly 
        115                 120                 125             


Val Gly Leu Lys Thr Ser Glu Lys Trp Phe Arg Met Gly Phe Arg Thr 
    130                 135                 140                 


Leu Ser Arg Val Arg Ser Asp Lys Ser Leu His Leu Thr Arg Met Gln 
145                 150                 155                 160 


Gln Ala Gly Phe Leu Tyr Tyr Glu Asp Leu Ala Ser Cys Val Thr Arg 
                165                 170                 175     


Ala Glu Ala Glu Ala Val Gly Val Leu Val Lys Glu Ala Val Gly Ala 
            180                 185                 190         


Phe Leu Pro Asp Ala Leu Val Thr Ile Thr Gly Gly Phe Arg Arg Gly 
        195                 200                 205             


Lys Lys Thr Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro Gly Ser 
    210                 215                 220                 


Thr Glu Glu Lys Glu Glu Glu Leu Leu Gln Lys Val Leu Asn Leu Trp 
225                 230                 235                 240 


Glu Lys Lys Gly Leu Leu Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe 
                245                 250                 255     


Glu Lys Leu Lys Thr Pro Ser Arg Lys Val Asp Ala Leu Asp His Phe 
            260                 265                 270         


Pro Lys Cys Phe Leu Ile Leu Lys Leu His His Gln Arg Val Asp Gly 
        275                 280                 285             


Asp Lys Pro Ser Gln Gln Glu Gly Lys Ser Trp Lys Ala Ile Arg Val 
    290                 295                 300                 


Asp Leu Val Met Cys Pro Tyr Glu Arg His Ala Phe Ala Leu Leu Gly 
305                 310                 315                 320 


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr 
                325                 330                 335     


His Glu Arg Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
            340                 345                 350         


Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Asp Ile Phe Ala His 
        355                 360                 365             


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
    370                 375                 380     


<210>  32
<211>  525
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  32

Met Ser Phe Ala Met Phe Pro Ala Lys Lys Glu His Leu Lys Lys Lys 
1               5                   10                  15      


Arg Arg Arg Met Asn Gly Cys Ile Ser Pro Thr Leu Tyr Glu Ile Lys 
            20                  25                  30          


Phe Asn Glu Phe Val Leu Phe Ile Leu Glu Lys Lys Met Gly Thr Thr 
        35                  40                  45              


Arg Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val 
    50                  55                  60                  


Glu Ser Glu Leu Ser Glu Ser Val Thr His Ile Val Ala Glu Asn Asn 
65                  70                  75                  80  


Ser Cys Ser Asp Val Leu Glu Trp Leu Ala Val Gln Asn Val Gly Asp 
                85                  90                  95      


Ser Ser Arg Phe Glu Leu Leu Asp Ile Ser Trp Leu Thr Glu Cys Met 
            100                 105                 110         


Lys Val Gly Lys Pro Val Glu Ala Ile Gly Lys His Gln Leu Met Arg 
        115                 120                 125             


Gly Asn Cys Leu Thr Asn Ser Ala Pro Ile Asn Cys Met Thr Glu Thr 
    130                 135                 140                 


Pro Ser Leu Ala Thr Lys Gln Val Ser Gln Tyr Ala Cys Glu Arg Arg 
145                 150                 155                 160 


Thr Thr Leu Asn Asn Cys Asn Gln Lys Phe Thr Asp Ala Phe Glu Ile 
                165                 170                 175     


Leu Ala Lys Asp Phe Glu Phe Arg Glu Asn Glu Gly Ile Cys Leu Ala 
            180                 185                 190         


Phe Met Arg Ala Ile Ser Val Leu Lys Cys Leu Pro Phe Thr Ile Val 
        195                 200                 205             


Arg Met Lys Asp Ile Glu Gly Val Pro Trp Leu Gly Asp Gln Val Lys 
    210                 215                 220                 


Ser Ile Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Ser Val Lys 
225                 230                 235                 240 


Ala Val Leu Asn Asp Glu Arg Tyr Arg Ser Phe Gln Leu Phe Asn Ser 
                245                 250                 255     


Val Phe Glu Val Gly Leu Thr Asp Asn Gly Glu Asn Gly Ile Ala Arg 
            260                 265                 270         


Gly Phe Gln Thr Leu Asn Glu Val Ile Thr Asp Glu Asn Ile Ser Leu 
        275                 280                 285             


Thr Lys Thr Thr Leu Ser Thr Ser Leu Trp Asn Tyr Leu Pro Gly Phe 
    290                 295                 300                 


Leu Tyr Tyr Glu Asp Leu Val Ser Cys Val Ala Lys Glu Glu Ala Asp 
305                 310                 315                 320 


Ala Val Tyr Leu Ile Val Lys Glu Ala Val Arg Ala Phe Leu Pro Glu 
                325                 330                 335     


Ala Leu Val Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Lys Ile Gly 
            340                 345                 350         


His Asp Val Asp Phe Leu Ile Ser Asp Pro Glu Ser Gly Gln Asp Glu 
        355                 360                 365             


Gln Leu Leu Pro Asn Ile Ile Lys Leu Trp Glu Lys Gln Glu Leu Leu 
    370                 375                 380                 


Leu Tyr Tyr Asp Leu Val Glu Ser Thr Phe Glu Lys Thr Lys Ile Pro 
385                 390                 395                 400 


Ser Arg Lys Val Asp Ala Met Asp His Phe Gln Lys Cys Phe Leu Ile 
                405                 410                 415     


Leu Lys Leu His His Gln Lys Val Asp Ser Gly Arg Tyr Lys Pro Pro 
            420                 425                 430         


Pro Glu Ser Lys Asn His Glu Ala Lys Asn Trp Lys Ala Ile Arg Val 
        435                 440                 445             


Asp Leu Val Met Cys Pro Phe Glu Gln Tyr Ala Tyr Ala Leu Leu Gly 
    450                 455                 460                 


Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr 
465                 470                 475                 480 


His Glu Lys Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr 
                485                 490                 495     


Lys Lys Ile Phe Leu Lys Ala Glu Ser Glu Glu Asp Ile Phe Thr His 
            500                 505                 510         


Leu Gly Leu Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
        515                 520                 525 


<210>  33
<211>  394
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  33

Leu Thr Asn Ser Ala Pro Ile Asn Cys Met Thr Glu Thr Pro Ser Leu 
1               5                   10                  15      


Ala Thr Lys Gln Val Ser Gln Tyr Ala Cys Glu Arg Arg Thr Thr Leu 
            20                  25                  30          


Asn Asn Cys Asn Gln Lys Phe Thr Asp Ala Phe Glu Ile Leu Ala Lys 
        35                  40                  45              


Asp Phe Glu Phe Arg Glu Asn Glu Gly Ile Cys Leu Ala Phe Met Arg 
    50                  55                  60                  


Ala Ile Ser Val Leu Lys Cys Leu Pro Phe Thr Ile Val Arg Met Lys 
65                  70                  75                  80  


Asp Ile Glu Gly Val Pro Trp Leu Gly Asp Gln Val Lys Ser Ile Ile 
                85                  90                  95      


Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Ser Val Lys Ala Val Leu 
            100                 105                 110         


Asn Asp Glu Arg Tyr Arg Ser Phe Gln Leu Phe Asn Ser Val Phe Glu 
        115                 120                 125             


Val Gly Leu Thr Asp Asn Gly Glu Asn Gly Ile Ala Arg Gly Phe Gln 
    130                 135                 140                 


Thr Leu Asn Glu Val Ile Thr Asp Glu Asn Ile Ser Leu Thr Lys Thr 
145                 150                 155                 160 


Thr Leu Ser Thr Ser Leu Trp Asn Tyr Leu Pro Gly Phe Leu Tyr Tyr 
                165                 170                 175     


Glu Asp Leu Val Ser Cys Val Ala Lys Glu Glu Ala Asp Ala Val Tyr 
            180                 185                 190         


Leu Ile Val Lys Glu Ala Val Arg Ala Phe Leu Pro Glu Ala Leu Val 
        195                 200                 205             


Thr Leu Thr Gly Gly Phe Arg Arg Gly Lys Lys Ile Gly His Asp Val 
    210                 215                 220                 


Asp Phe Leu Ile Ser Asp Pro Glu Ser Gly Gln Asp Glu Gln Leu Leu 
225                 230                 235                 240 


Pro Asn Ile Ile Lys Leu Trp Glu Lys Gln Glu Leu Leu Leu Tyr Tyr 
                245                 250                 255     


Asp Leu Val Glu Ser Thr Phe Glu Lys Thr Lys Ile Pro Ser Arg Lys 
            260                 265                 270         


Val Asp Ala Met Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu 
        275                 280                 285             


His His Gln Lys Val Asp Ser Gly Arg Tyr Lys Pro Pro Pro Glu Ser 
    290                 295                 300                 


Lys Asn His Glu Ala Lys Asn Trp Lys Ala Ile Arg Val Asp Leu Val 
305                 310                 315                 320 


Met Cys Pro Phe Glu Gln Tyr Ala Tyr Ala Leu Leu Gly Trp Thr Gly 
                325                 330                 335     


Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr Ala Thr His Glu Lys 
            340                 345                 350         


Lys Met Met Leu Asp Asn His Ala Leu Tyr Asp Lys Thr Lys Lys Ile 
        355                 360                 365             


Phe Leu Lys Ala Glu Ser Glu Glu Asp Ile Phe Thr His Leu Gly Leu 
    370                 375                 380                 


Asp Tyr Ile Glu Pro Trp Glu Arg Asn Ala 
385                 390                 


<210>  34
<211>  479
<212>  PRT
<213>  Jaculus jaculus

<400>  34

Met Asp Pro Glu Gln Ala Ala His Trp Ser Pro Arg Lys Lys Arg Pro 
1               5                   10                  15      


Arg Gln Arg Ser Ala Ser Val Ala Ser Ala Pro His Asp Ile Arg Phe 
            20                  25                  30          


Gln Asp Leu Val Leu Phe Ile Leu Glu Lys Lys Met Gly Ser Thr Arg 
        35                  40                  45              


Arg Ala Phe Leu Met Glu Leu Ala Arg Arg Lys Gly Phe Arg Val Glu 
    50                  55                  60                  


Asn Glu Leu Ser Asp Ser Val Thr His Ile Val Ala Glu Asn Asn Ser 
65                  70                  75                  80  


Gly Ser Asp Val Met Lys Trp Leu Gln Gly Gln Asn Ile Gln Ala Ser 
                85                  90                  95      


Ser Glu Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met Gly 
            100                 105                 110         


Ala Gly Lys Pro Val Glu Met Thr Gly Arg His Gln Leu Val Lys Gln 
        115                 120                 125             


Thr Phe Cys Leu Pro Gly Phe Ile Leu Gln Asp Ala Phe Asp Ile Leu 
    130                 135                 140                 


Ala Glu Asn Cys Glu Phe Arg Glu Asn Glu Ala Ser Cys Val Glu Phe 
145                 150                 155                 160 


Met Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Pro Ile Ile Ser 
                165                 170                 175     


Val Lys Asp Thr Glu Gly Ile Pro Trp Leu Gly Gly Lys Val Lys Cys 
            180                 185                 190         


Val Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys Ala 
        195                 200                 205             


Leu Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser Val 
    210                 215                 220                 


Phe Gly Val Gly Leu Lys Thr Ala Glu Arg Trp Phe Arg Met Gly Phe 
225                 230                 235                 240 


Arg Thr Leu Ser Thr Val Lys Leu Asp Lys Ser Leu Thr Phe Thr Arg 
                245                 250                 255     


Met Gln Lys Ala Gly Phe Leu His Tyr Glu Asp Leu Val Ser Cys Val 
            260                 265                 270         


Thr Arg Ala Glu Ala Glu Ala Val Ser Val Leu Val Gln Gln Ala Val 
        275                 280                 285             


Val Ala Phe Leu Pro Asp Ala Leu Val Ser Met Thr Gly Gly Phe Arg 
    290                 295                 300                 


Arg Gly Lys Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser Pro 
305                 310                 315                 320 


Glu Ala Thr Glu Glu Glu Glu Gln Gln Leu Leu His Lys Val Thr Asn 
                325                 330                 335     


Phe Trp Glu Gln Lys Gly Leu Leu Leu Tyr Cys Asp His Val Glu Ser 
            340                 345                 350         


Thr Phe Glu Lys Cys Lys Leu Pro Ser Arg Lys Val Asp Ala Leu Asp 
        355                 360                 365             


His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Tyr Arg Glu Arg Val 
    370                 375                 380                 


Asp Ser Val Lys Ser Ser Gln Gln Glu Gly Lys Gly Trp Lys Ala Ile 
385                 390                 395                 400 


Arg Val Asp Leu Val Met Cys Pro Tyr Glu Cys Arg Ala Phe Ala Leu 
                405                 410                 415     


Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg Tyr 
            420                 425                 430         


Ala Thr His Glu Arg Lys Met Arg Leu Asp Asn His Ala Leu Tyr Asp 
        435                 440                 445             


Lys Thr Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile Phe 
    450                 455                 460                 


Ala His Leu Gly Leu Glu Tyr Ile Glu Pro Leu Glu Arg Asn Ala 
465                 470                 475                 


<210>  35
<211>  384
<212>  PRT
<213>  Jaculus jaculus

<400>  35

Ser Ser Glu Leu Glu Leu Leu Asp Val Ser Trp Leu Ile Glu Cys Met 
1               5                   10                  15      


Gly Ala Gly Lys Pro Val Glu Met Thr Gly Arg His Gln Leu Val Lys 
            20                  25                  30          


Gln Thr Phe Cys Leu Pro Gly Phe Ile Leu Gln Asp Ala Phe Asp Ile 
        35                  40                  45              


Leu Ala Glu Asn Cys Glu Phe Arg Glu Asn Glu Ala Ser Cys Val Glu 
    50                  55                  60                  


Phe Met Arg Ala Ala Ser Val Leu Lys Ser Leu Pro Phe Pro Ile Ile 
65                  70                  75                  80  


Ser Val Lys Asp Thr Glu Gly Ile Pro Trp Leu Gly Gly Lys Val Lys 
                85                  90                  95      


Cys Val Ile Glu Glu Ile Ile Glu Asp Gly Glu Ser Ser Glu Val Lys 
            100                 105                 110         


Ala Leu Leu Asn Asp Glu Arg Tyr Lys Ser Phe Lys Leu Phe Thr Ser 
        115                 120                 125             


Val Phe Gly Val Gly Leu Lys Thr Ala Glu Arg Trp Phe Arg Met Gly 
    130                 135                 140                 


Phe Arg Thr Leu Ser Thr Val Lys Leu Asp Lys Ser Leu Thr Phe Thr 
145                 150                 155                 160 


Arg Met Gln Lys Ala Gly Phe Leu His Tyr Glu Asp Leu Val Ser Cys 
                165                 170                 175     


Val Thr Arg Ala Glu Ala Glu Ala Val Ser Val Leu Val Gln Gln Ala 
            180                 185                 190         


Val Val Ala Phe Leu Pro Asp Ala Leu Val Ser Met Thr Gly Gly Phe 
        195                 200                 205             


Arg Arg Gly Lys Lys Ile Gly His Asp Val Asp Phe Leu Ile Thr Ser 
    210                 215                 220                 


Pro Glu Ala Thr Glu Glu Glu Glu Gln Gln Leu Leu His Lys Val Thr 
225                 230                 235                 240 


Asn Phe Trp Glu Gln Lys Gly Leu Leu Leu Tyr Cys Asp His Val Glu 
                245                 250                 255     


Ser Thr Phe Glu Lys Cys Lys Leu Pro Ser Arg Lys Val Asp Ala Leu 
            260                 265                 270         


Asp His Phe Gln Lys Cys Phe Leu Ile Leu Lys Leu Tyr Arg Glu Arg 
        275                 280                 285             


Val Asp Ser Val Lys Ser Ser Gln Gln Glu Gly Lys Gly Trp Lys Ala 
    290                 295                 300                 


Ile Arg Val Asp Leu Val Met Cys Pro Tyr Glu Cys Arg Ala Phe Ala 
305                 310                 315                 320 


Leu Leu Gly Trp Thr Gly Ser Arg Gln Phe Glu Arg Asp Leu Arg Arg 
                325                 330                 335     


Tyr Ala Thr His Glu Arg Lys Met Arg Leu Asp Asn His Ala Leu Tyr 
            340                 345                 350         


Asp Lys Thr Lys Arg Val Phe Leu Lys Ala Glu Ser Glu Glu Glu Ile 
        355                 360                 365             


Phe Ala His Leu Gly Leu Glu Tyr Ile Glu Pro Leu Glu Arg Asn Ala 
    370                 375                 380                 


