                         SEQUENCE LISTING

<110>  Sunshine Lake Pharma Co., Ltd.
        
<120>  Anti-TrkA ANTIBODIES AND USES THEREOF

<130>  2020-5-26

<160>  152   

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  1

Val Tyr Ser Phe Thr Ala Tyr Thr 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  2

Ile Asn Pro His Asn Gly Gly Thr 
1               5               


<210>  3
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  3

Ala Ile Ser Arg Tyr Gly Ser Ser Ser Phe Tyr Phe Asp Val 
1               5                   10                  


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  4

Gly Tyr Ala Phe Thr Asn Tyr Trp 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  5

Phe Tyr Pro Arg Thr Gly Asn Thr 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  6

Ala Arg Ala Gly Thr Gly Phe Asp Tyr 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  7

Gly Tyr Arg Phe Ser Ser Tyr Trp 
1               5               


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  8

Ile Leu Pro Gly Arg Gly Ile Ile 
1               5               


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  9

Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val 
1               5                   10  


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  10

Gly Tyr Thr Phe Ser Thr Tyr Trp 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  11

Asn Leu Pro Gly Arg His Ile Thr 
1               5               


<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  12

Ala Arg Gly Arg Gly Thr Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  13

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  14

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  15

Ala Phe Ser Tyr Tyr Gly Ser Arg Gly Phe Tyr Phe Asp Tyr 
1               5                   10                  


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  16

Gly Tyr Ser Phe Thr Gly Tyr Thr 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  17

Ile Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  18
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  18

Ala Ser Ser Ser Tyr Arg Asn Asp Gly Asn Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  19

Gly Tyr Ser Ile Thr Gly Tyr Thr 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  20

Val Asn Pro Tyr Asn Gly Gly Thr 
1               5               


<210>  21
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  21

Ala Ile Ser Arg Tyr Gly Ser Glu Ser Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  22

Gly Tyr Thr Phe Asn Ile Tyr Trp 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  23

Ile Leu Pro Gly Ser Gly Asn Thr 
1               5               


<210>  24
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  24

Ala Arg Thr Asp Gly Arg Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  25

Gly Tyr Thr Phe Ser Ser Tyr Trp 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  26

Phe Leu Pro Arg Ser Gly Lys Thr 
1               5               


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region CDR sequence

<400>  27

Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val 
1               5                   10  


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  28

Ser Ser Ile Ser Tyr 
1               5   


<210>  29
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  29

Ala Thr Ser 
1               


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  30

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  31

Glu Asn Val Gly Gly Tyr 
1               5       


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  32

Gly Ala Ser 
1               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  33

Gly Gln Asn Tyr Ile Tyr Pro Phe Thr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  34

Thr Gly Ala Val Thr Ile Ser Asn Tyr 
1               5                   


<210>  35
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  35

Gly Thr Asn 
1               


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  36

Val Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  37

Gln Ser Leu Leu His Ser Asn Gly Ile Thr Tyr 
1               5                   10      


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  38

Gln Met Ser 
1               


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  39

Ala Gln Asn Leu Glu Phe Pro Phe Thr 
1               5                   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  40

Ser Ser Val Ser Tyr 
1               5   


<210>  41
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  41

Leu Thr Ser 
1               


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  42

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  43

Ser Ser Val Ser Tyr 
1               5   


<210>  44
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  44

Asp Thr Ser 
1               


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  45

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  46

Ser Ser Val Ser Tyr 
1               5   


<210>  47
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  47

Ala Thr Ser 
1               


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  48

Gln Gln Trp Ser Ser Asn Pro Pro Thr 
1               5                   


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  49

Lys Ser Val Ser Ser Ser Ala Tyr Ser Tyr 
1               5                   10  


<210>  50
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  50

Leu Ala Ser 
1               


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  51

Gln His Ser Arg Glu Leu Pro Phe Thr 
1               5                   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  52

Ser Asn Ile Ser Tyr 
1               5   


<210>  53
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  53

Asp Thr Ser 
1               


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region CDR sequence

<400>  54

Gln Gln Trp Ser Ser Val Pro Leu Thr 
1               5                   


<210>  55
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  55

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Val Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro His Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Ser Ser Phe Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Ala Val Ser Ser 
        115                 120     


<210>  56
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  56

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  57
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  57

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Thr Gly Tyr Arg Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Gly Ile Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  58
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  58

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Asn Leu Pro Gly Arg His Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Leu Thr Val Ser Ser 
        115             


<210>  59
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  59

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ser Tyr Tyr Gly Ser Arg Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120     


<210>  60
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  60

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Ser Tyr Arg Asn Asp Gly Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  61
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  61

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Glu Ser Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  62
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  62

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Asn Ile Tyr 
            20                  25                  30          


Trp Ile Asp Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  63
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region

<400>  63

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Phe Leu Pro Arg Ser Gly Lys Thr Asn Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser 
        115         


<210>  64
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  64

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys 
            100                 105     


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  65

Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  66

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ile Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  67
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  67

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Thr Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  68
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  68

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  69
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  69

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  70
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  70

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Lys Lys 
            100                 105     


<210>  71
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  71

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Thr Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  72
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region

<400>  72

Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Val Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  73
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 wild type Fc sequence

<400>  73

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  74
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length sequence of the constant region of the antibody

<400>  74

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly 
                325     


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full-length sequence of the constant region of the antibody

<400>  75

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  76
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  76

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Val Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro His Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Ser Ser Phe Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Ala Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  77
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  77

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440         


<210>  78
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  78

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Thr Gly Tyr Arg Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Gly Ile Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  79
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  79

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Asn Leu Pro Gly Arg His Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  80
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  80

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ser Tyr Tyr Gly Ser Arg Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  81
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  81

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Ser Tyr Arg Asn Asp Gly Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


<210>  82
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  82

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Glu Ser Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445         


<210>  83
<211>  444
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  83

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Asn Ile Tyr 
            20                  25                  30          


Trp Ile Asp Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 


<210>  84
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain

<400>  84

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Phe Leu Pro Arg Ser Gly Lys Thr Asn Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440             


<210>  85
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  85

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  86
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  86

Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  87
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  87

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ile Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  88
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  88

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Thr Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  89
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  89

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  90
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  90

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  91
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  91

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Lys Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  92
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  92

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Thr Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  93
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain

<400>  93

Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Val Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  94
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  94

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Gly Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Leu Leu Gln Gln Ser 
        115                 120                 125             


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys 
    130                 135                 140                 


Ala Ser Val Tyr Ser Phe Thr Ala Tyr Thr Met Asn Trp Val Lys Gln 
145                 150                 155                 160 


Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro His Asn 
                165                 170                 175     


Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            180                 185                 190         


Leu Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu Leu Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ile Ser Arg Tyr Gly Ser 
    210                 215                 220                 


Ser Ser Phe Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Ala Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  95
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  95

Glu Val Leu Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Val Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro His Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Leu Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Ser Ser Phe Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Ala Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Ser Ser Ser Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Ser Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Gly Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Asn Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  96
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  96

Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Gly Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile Tyr Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Ser Gly Ala Glu Leu Val Arg Pro Gly Thr Ser Val Lys Ile Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr Trp Leu Gly Trp Met Lys 
145                 150                 155                 160 


Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Asp Phe Tyr Pro Arg 
                165                 170                 175     


Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe Lys Gly Lys Val Thr Leu 
            180                 185                 190         


Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys Ala Arg Ala Gly Thr Gly 
    210                 215                 220                 


Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
225                 230                 235             


<210>  97
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  97

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Tyr 
            20                  25                  30          


Trp Leu Gly Trp Met Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Phe Tyr Pro Arg Thr Gly Asn Thr Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Leu Cys 
                85                  90                  95      


Ala Arg Ala Gly Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met 
    130                 135                 140                 


Ser Val Gly Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val 
145                 150                 155                 160 


Gly Gly Tyr Val Ser Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Gly Ala Ser Ser Arg His Thr Gly Val Pro Asp Arg 
            180                 185                 190         


Phe Thr Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Val Gln Ala Glu Asp Leu Ala Ala Tyr His Cys Gly Gln Asn Tyr Ile 
    210                 215                 220                 


Tyr Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235             


<210>  98
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  98

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Ile Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Pro Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly 
            100                 105                 110         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
        115                 120                 125             


Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val Lys Ile 
    130                 135                 140                 


Ser Cys Lys Thr Thr Gly Tyr Arg Phe Ser Ser Tyr Trp Ile Glu Trp 
145                 150                 155                 160 


Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu Gly Glu Ile Leu 
                165                 170                 175     


Pro Gly Arg Gly Ile Ile Asn Tyr Asn Glu Asn Phe Arg Gly Lys Ala 
            180                 185                 190         


Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Val Gln Leu Ser 
        195                 200                 205             


Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Thr Asp 
    210                 215                 220                 


Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  99
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  99

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Thr Gly Tyr Arg Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Arg Gly Ile Ile Asn Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Val Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr 
    130                 135                 140                 


Ser Pro Gly Glu Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala 
145                 150                 155                 160 


Val Thr Ile Ser Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His 
                165                 170                 175     


Leu Phe Thr Gly Leu Ile Gly Gly Thr Asn Asn Arg Pro Pro Gly Val 
            180                 185                 190         


Pro Ala Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr 
        195                 200                 205             


Ile Thr Gly Ala Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Val Leu 
    210                 215                 220                 


Trp Tyr Ser Asn His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  100
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  100

Asp Ile Val Met Thr Gln Ala Ala Phe Ser Thr Pro Val Thr Leu Gly 
1               5                   10                  15      


Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser 
    130                 135                 140                 


Met Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Thr Tyr Trp 
145                 150                 155                 160 


Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Glu Asn Leu Pro Gly Arg His Ile Thr Asn Tyr Asn Glu Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met 
        195                 200                 205             


Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Gly Arg Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Pro 
225                 230                 235                 240 


Leu Thr Val Ser Ser 
                245 


<210>  101
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  101

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Asn Leu Pro Gly Arg His Ile Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Gly Thr Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Pro Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Phe Ser Thr 
    130                 135                 140                 


Pro Val Thr Leu Gly Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu 
            180                 185                 190         


Ala Ser Gly Val Pro Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Gln Asn Leu Glu Phe Pro Phe Thr Phe Gly Ser Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys 
                245 


<210>  102
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  102

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Thr Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln 
145                 150                 155                 160 


Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn 
                165                 170                 175     


Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Phe Ser Tyr Tyr Gly Ser 
    210                 215                 220                 


Arg Gly Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  103
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  103

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ser Tyr Tyr Gly Ser Arg Gly Phe Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Leu Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Thr Ser Ser Val Ser Tyr Ile Tyr Trp Tyr Gln Gln Lys Pro Arg 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Leu Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  104
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  104

Asp Ile Val Met Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Thr Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn Trp Val Lys Gln 
145                 150                 155                 160 


Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Ile Asn Pro Tyr Asn 
                165                 170                 175     


Gly Gly Thr Arg Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ser Ser Ser Tyr Arg Asn 
    210                 215                 220                 


Asp Gly Asn Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  105
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  105

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Asn Pro Tyr Asn Gly Gly Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Ser Ser Tyr Arg Asn Asp Gly Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser 
                165                 170                 175     


Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Met Glu Thr Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  106
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  106

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Thr Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Lys Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Met Lys Ile Ser Cys Lys 
    130                 135                 140                 


Ala Ser Gly Tyr Ser Ile Thr Gly Tyr Thr Met Asn Trp Val Lys Gln 
145                 150                 155                 160 


Ser His Gly Lys Asn Leu Glu Trp Ile Gly Leu Val Asn Pro Tyr Asn 
                165                 170                 175     


Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Leu Ser Leu Lys 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Ile Ser Arg Tyr Gly Ser 
    210                 215                 220                 


Glu Ser Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  107
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  107

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Met Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Ile Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Asn Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asn Pro Tyr Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Leu Ser Leu Lys Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Ser Arg Tyr Gly Ser Glu Ser Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Ser Gln Ser Pro 
    130                 135                 140                 


Ala Ile Leu Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Arg 
145                 150                 155                 160 


Ala Thr Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Tyr Ala Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Arg Val Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Ser Asn Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Lys Lys 
        


<210>  108
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  108

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Val Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Thr Ser Lys Ser Val Ser Ser Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Val Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        115                 120                 125             


His Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val 
    130                 135                 140                 


Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Asn Ile Tyr Trp Ile 
145                 150                 155                 160 


Asp Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile Gly Glu 
                165                 170                 175     


Ile Leu Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Asn Phe Lys Gly 
            180                 185                 190         


Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln 
        195                 200                 205             


Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Thr Asp Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  109
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  109

Gln Val His Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Asn Ile Tyr 
            20                  25                  30          


Trp Ile Asp Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr His Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Gly Arg Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Val Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Thr Ser Lys 
145                 150                 155                 160 


Ser Val Ser Ser Ser Ala Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Val Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln His Ser Arg Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  110
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  110

Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Val Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser 
        115                 120                 125             


Gly Ala Glu Leu Met Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys 
    130                 135                 140                 


Ala Thr Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu Trp Val Lys Gln 
145                 150                 155                 160 


Arg Pro Gly His Gly Leu Glu Trp Leu Gly Glu Phe Leu Pro Arg Ser 
                165                 170                 175     


Gly Lys Thr Asn Tyr Asn Glu Glu Phe Arg Gly Lys Ala Thr Phe Thr 
            180                 185                 190         


Ala Asp Thr Ser Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr 
        195                 200                 205             


Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Thr Asp Pro Pro Tyr 
    210                 215                 220                 


Phe Gly Val Trp Gly Ala Gly Thr Met Val Ala Val Ser Ser 
225                 230                 235             


<210>  111
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single chain antibody fragment

<400>  111

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Glu Phe Leu Pro Arg Ser Gly Lys Thr Asn Tyr Asn Glu Glu Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Asp Pro Pro Tyr Phe Gly Val Trp Gly Ala Gly Thr Met 
            100                 105                 110         


Val Ala Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Pro Ile Met Ser 
    130                 135                 140                 


Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Asn 
145                 150                 155                 160 


Ile Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys 
                165                 170                 175     


Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser 
        195                 200                 205             


Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser 
    210                 215                 220                 


Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235             


<210>  112
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  112
gaagtgctgc tgcagcagag cggaccagag ctggtcaagc ccggcgcctc catgaagatc       60

agctgtaagg cctccgtgta cagcttcaca gcctacacaa tgaactgggt gaagcagagc      120

cacggcaaga atctggagtg gatcggactg atcaacccac acaatggcgg cactaggtac      180

aaccagaagt tcaagggcaa ggccacactg actctggata agtccagcag cactgcctac      240

atggatctgc tgtctctgac aagcgaggac agcgccgtct actattgcgc catctctagg      300

tacggcagca gcagcttcta cttcgatgtg tggggcgccg gcacaacagt ggctgtgagc      360

agcgccagca ccaagggccc cagcgtgttc cctctggctc cttgtagccg gtccacctcc      420

gagtccacag ctgctctggg ctgcctcgtg aaggactact ttcccgaacc cgttaccgtg      480

agctggaata gcggcgcttt aacctccgga gtgcacacct tccccgctgt gctccagtcc      540

tccggtttat actctttatc ctccgtggtg accgtgcctt cctccagcct cggcaccaag      600

acctacactt gtaacgtgga ccacaagccc agcaacacca aggtggacaa gagggtggag      660

tccaagtacg gacctccttg tcccccttgc cccgcccccg aggccgctgg cggaccctcc      720

gtgttcctct tcccccccaa acccaaggac actttaatga tctcccggac ccccgaagtg      780

acttgtgtgg tggtggacgt gtcccaagaa gaccccgagg tgcagtttaa ctggtacgtg      840

gatggcgtgg aggtgcacaa cgccaagacc aagcctaggg aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct caccgtgctg catcaagatt ggctgaacgg caaggagtac      960

aagtgcaagg tgagcaacaa gggactgccc agctccatcg agaagaccat cagcaaggcc     1020

aaaggccagc cccgggaacc tcaagtttat acactgcccc ccagccaaga agagatgacc     1080

aagaaccaag tttctttaac ttgtttagtg aagggcttct accctagcga catcgctgtg     1140

gagtgggagt ccaatggcca gcccgaaaac aattataaga ccaccccccc cgtgctggac     1200

tccgatggtt cttttttttt atactccaag ctgacagtgg acaagtctcg ttggcaagaa     1260

ggcaacgtgt tctcttgtag cgtgatgcac gaggctttac acaaccacta cacccagaag     1320

tctttatctc tgtctttagg ctgatgagaa ttc                                  1353


<210>  113
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  113
caagtgcagc tccagcagag cggagctgag ctggtgagac ccggcactag cgtgaagatc       60

agctgtaagg ccagcggcta cgccttcact aattactggc tgggctggat gaagcagaga      120

cccggccatg gactggagtg gatcggcgac ttctacccaa ggactggcaa cactttctac      180

aacgagaact ttaagggcaa ggtgactctg actgccgata agtccagcaa cactgcctac      240

atgcagctgt cctctctgac tagcgaagat agcgccgtgt atctgtgtgc tagggctggc      300

actggcttcg attactgggg ccaaggcaca acactgacag tgagcagcgc cagcaccaag      360

ggccccagcg tgttccctct ggctccttgt agccggtcca cctccgagtc cacagctgct      420

ctgggctgcc tcgtgaagga ctactttccc gaacccgtta ccgtgagctg gaatagcggc      480

gctttaacct ccggagtgca caccttcccc gctgtgctcc agtcctccgg tttatactct      540

ttatcctccg tggtgaccgt gccttcctcc agcctcggca ccaagaccta cacttgtaac      600

gtggaccaca agcccagcaa caccaaggtg gacaagaggg tggagtccaa gtacggacct      660

ccttgtcccc cttgccccgc ccccgaggcc gctggcggac cctccgtgtt cctcttcccc      720

cccaaaccca aggacacttt aatgatctcc cggacccccg aagtgacttg tgtggtggtg      780

gacgtgtccc aagaagaccc cgaggtgcag tttaactggt acgtggatgg cgtggaggtg      840

cacaacgcca agaccaagcc tagggaggaa cagttcaact ccacctaccg ggtggtgtcc      900

gtgctcaccg tgctgcatca agattggctg aacggcaagg agtacaagtg caaggtgagc      960

aacaagggac tgcccagctc catcgagaag accatcagca aggccaaagg ccagccccgg     1020

gaacctcaag tttatacact gccccccagc caagaagaga tgaccaagaa ccaagtttct     1080

ttaacttgtt tagtgaaggg cttctaccct agcgacatcg ctgtggagtg ggagtccaat     1140

ggccagcccg aaaacaatta taagaccacc ccccccgtgc tggactccga tggttctttt     1200

tttttatact ccaagctgac agtggacaag tctcgttggc aagaaggcaa cgtgttctct     1260

tgtagcgtga tgcacgaggc tttacacaac cactacaccc agaagtcttt atctctgtct     1320

ttaggctgat gagaattc                                                   1338


<210>  114
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  114
caagtgcagc tgcagcagag cggcgctgag ctgatgaagc ccggcgcttc cgtcaagatc       60

agctgcaaga ctactggcta taggttcagc agctactgga tcgagtgggt gaagcagaga      120

cccggccacg gactggaatg gctgggcgaa atcctccccg gaaggggcat catcaactac      180

aatgagaact ttaggggcaa ggccacattc acagccgaca caagcagcaa cactgcctac      240

gtgcagctga gctctctgac ttccgaggac agcgccgtgt acttctgcgc cagaacagac      300

cctccttatt tcggcgtgtg gggcgccgga actactgtga ctgtgtccag cgccagcacc      360

aagggcccca gcgtgttccc tctggctcct tgtagccggt ccacctccga gtccacagct      420

gctctgggct gcctcgtgaa ggactacttt cccgaacccg ttaccgtgag ctggaatagc      480

ggcgctttaa cctccggagt gcacaccttc cccgctgtgc tccagtcctc cggtttatac      540

tctttatcct ccgtggtgac cgtgccttcc tccagcctcg gcaccaagac ctacacttgt      600

aacgtggacc acaagcccag caacaccaag gtggacaaga gggtggagtc caagtacgga      660

cctccttgtc ccccttgccc cgcccccgag gccgctggcg gaccctccgt gttcctcttc      720

ccccccaaac ccaaggacac tttaatgatc tcccggaccc ccgaagtgac ttgtgtggtg      780

gtggacgtgt cccaagaaga ccccgaggtg cagtttaact ggtacgtgga tggcgtggag      840

gtgcacaacg ccaagaccaa gcctagggag gaacagttca actccaccta ccgggtggtg      900

tccgtgctca ccgtgctgca tcaagattgg ctgaacggca aggagtacaa gtgcaaggtg      960

agcaacaagg gactgcccag ctccatcgag aagaccatca gcaaggccaa aggccagccc     1020

cgggaacctc aagtttatac actgcccccc agccaagaag agatgaccaa gaaccaagtt     1080

tctttaactt gtttagtgaa gggcttctac cctagcgaca tcgctgtgga gtgggagtcc     1140

aatggccagc ccgaaaacaa ttataagacc accccccccg tgctggactc cgatggttct     1200

ttttttttat actccaagct gacagtggac aagtctcgtt ggcaagaagg caacgtgttc     1260

tcttgtagcg tgatgcacga ggctttacac aaccactaca cccagaagtc tttatctctg     1320

tctttaggct gatgagaatt c                                               1341


<210>  115
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  115
caagtgcagc tgcagcagag cggagccgag ctgatgaagc ccggcgcctc catgaagatc       60

agctgcaagg ccactggcta cacattcagc acatactgga tcgagtgggt caagcagaga      120

cccggccacg gactggagtg gatcggagag aatctgcccg gaaggcacat cactaactac      180

aacgagaagt tcaagggcaa ggccactttc acagccgaca ctagcagcaa cactgcctac      240

atgcagctca gctctctgac aagcgaagat agcgccgtgt actactgtgc taggggaagg      300

ggcacttact acttcgatta ctggggccaa ggcactccac tgactgtgtc cagcgccagc      360

accaagggcc ccagcgtgtt ccctctggct ccttgtagcc ggtccacctc cgagtccaca      420

gctgctctgg gctgcctcgt gaaggactac tttcccgaac ccgttaccgt gagctggaat      480

agcggcgctt taacctccgg agtgcacacc ttccccgctg tgctccagtc ctccggttta      540

tactctttat cctccgtggt gaccgtgcct tcctccagcc tcggcaccaa gacctacact      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agagggtgga gtccaagtac      660

ggacctcctt gtcccccttg ccccgccccc gaggccgctg gcggaccctc cgtgttcctc      720

ttccccccca aacccaagga cactttaatg atctcccgga cccccgaagt gacttgtgtg      780

gtggtggacg tgtcccaaga agaccccgag gtgcagttta actggtacgt ggatggcgtg      840

gaggtgcaca acgccaagac caagcctagg gaggaacagt tcaactccac ctaccgggtg      900

gtgtccgtgc tcaccgtgct gcatcaagat tggctgaacg gcaaggagta caagtgcaag      960

gtgagcaaca agggactgcc cagctccatc gagaagacca tcagcaaggc caaaggccag     1020

ccccgggaac ctcaagttta tacactgccc cccagccaag aagagatgac caagaaccaa     1080

gtttctttaa cttgtttagt gaagggcttc taccctagcg acatcgctgt ggagtgggag     1140

tccaatggcc agcccgaaaa caattataag accacccccc ccgtgctgga ctccgatggt     1200

tctttttttt tatactccaa gctgacagtg gacaagtctc gttggcaaga aggcaacgtg     1260

ttctcttgta gcgtgatgca cgaggcttta cacaaccact acacccagaa gtctttatct     1320

ctgtctttag gctgatgaga attc                                            1344


<210>  116
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  116
gaggtgcagc tccaacagag cggaccagag ctggtgaaac ccggcgccag catgaagatc       60

agctgtaagg cctccggcta cagcttcact ggctacacta tgaactgggt gaagcagtcc      120

cacggcaaga atctggagtg gatcggactg atcaacccat acaacggcgg cacaaactac      180

aaccagaagt tcaagggcaa ggccactctg acagtcgata agagctccag cactgcctac      240

atggagctgc tgagcctcac tagcgaggac agcgctgtgt actactgtgc cttctcctac      300

tacggctcta ggggcttcta cttcgattac tggggccaag gcacaacact gacagtgtcc      360

agcgccagca ccaagggccc cagcgtgttc cctctggctc cttgtagccg gtccacctcc      420

gagtccacag ctgctctggg ctgcctcgtg aaggactact ttcccgaacc cgttaccgtg      480

agctggaata gcggcgcttt aacctccgga gtgcacacct tccccgctgt gctccagtcc      540

tccggtttat actctttatc ctccgtggtg accgtgcctt cctccagcct cggcaccaag      600

acctacactt gtaacgtgga ccacaagccc agcaacacca aggtggacaa gagggtggag      660

tccaagtacg gacctccttg tcccccttgc cccgcccccg aggccgctgg cggaccctcc      720

gtgttcctct tcccccccaa acccaaggac actttaatga tctcccggac ccccgaagtg      780

acttgtgtgg tggtggacgt gtcccaagaa gaccccgagg tgcagtttaa ctggtacgtg      840

gatggcgtgg aggtgcacaa cgccaagacc aagcctaggg aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct caccgtgctg catcaagatt ggctgaacgg caaggagtac      960

aagtgcaagg tgagcaacaa gggactgccc agctccatcg agaagaccat cagcaaggcc     1020

aaaggccagc cccgggaacc tcaagtttat acactgcccc ccagccaaga agagatgacc     1080

aagaaccaag tttctttaac ttgtttagtg aagggcttct accctagcga catcgctgtg     1140

gagtgggagt ccaatggcca gcccgaaaac aattataaga ccaccccccc cgtgctggac     1200

tccgatggtt cttttttttt atactccaag ctgacagtgg acaagtctcg ttggcaagaa     1260

ggcaacgtgt tctcttgtag cgtgatgcac gaggctttac acaaccacta cacccagaag     1320

tctttatctc tgtctttagg ctgatgagaa ttc                                  1353


<210>  117
<211>  1356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  117
gaagtgcagc tgcaacagag cggcccagag ctcgtgaagc ccggcgccag catgaagatc       60

agctgcaagg ccagcggcta cagcttcact ggctacacaa tgaactgggt caagcagagc      120

cacggaaaaa atctggagtg gatcggactg atcaaccctt acaacggcgg cacaaggtac      180

aatcagaagt tcaagggcaa ggccactctc actgtggata agagcagcag cactgcctac      240

atggagctgc tgtctctgac aagcgaggat agcgccgtgt actactgcgc cagctcctcc      300

tataggaacg acggcaactg gtacttcgat gtgtggggcg ccggcactac tgtgacagtg      360

agctccgcca gcaccaaggg ccccagcgtg ttccctctgg ctccttgtag ccggtccacc      420

tccgagtcca cagctgctct gggctgcctc gtgaaggact actttcccga acccgttacc      480

gtgagctgga atagcggcgc tttaacctcc ggagtgcaca ccttccccgc tgtgctccag      540

tcctccggtt tatactcttt atcctccgtg gtgaccgtgc cttcctccag cctcggcacc      600

aagacctaca cttgtaacgt ggaccacaag cccagcaaca ccaaggtgga caagagggtg      660

gagtccaagt acggacctcc ttgtccccct tgccccgccc ccgaggccgc tggcggaccc      720

tccgtgttcc tcttcccccc caaacccaag gacactttaa tgatctcccg gacccccgaa      780

gtgacttgtg tggtggtgga cgtgtcccaa gaagaccccg aggtgcagtt taactggtac      840

gtggatggcg tggaggtgca caacgccaag accaagccta gggaggaaca gttcaactcc      900

acctaccggg tggtgtccgt gctcaccgtg ctgcatcaag attggctgaa cggcaaggag      960

tacaagtgca aggtgagcaa caagggactg cccagctcca tcgagaagac catcagcaag     1020

gccaaaggcc agccccggga acctcaagtt tatacactgc cccccagcca agaagagatg     1080

accaagaacc aagtttcttt aacttgttta gtgaagggct tctaccctag cgacatcgct     1140

gtggagtggg agtccaatgg ccagcccgaa aacaattata agaccacccc ccccgtgctg     1200

gactccgatg gttctttttt tttatactcc aagctgacag tggacaagtc tcgttggcaa     1260

gaaggcaacg tgttctcttg tagcgtgatg cacgaggctt tacacaacca ctacacccag     1320

aagtctttat ctctgtcttt aggctgatga gaattc                               1356


<210>  118
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  118
gaagtgcagc tgcagcagag cggaccagag ctggtcaagc ccggcgccag catgaagatc       60

agctgtaagg ccagcggcta cagcatcact ggctacacta tgaactgggt gaagcagagc      120

cacggcaaga acctcgagtg gattggcctc gtgaacccat acaacggcgg cacttcctac      180

aaccagaagt tcaaaggcaa ggccacactc acagtcgata agtccagctc cacagcctac      240

atggagctgc tgtctctgaa gagcgaggat agcgctgtct actactgtgc catcagcaga      300

tacggcagcg agagctggta cttcgacgtg tggggcgccg gcacaacagt gacagtgagc      360

agcgccagca caaagggccc cagcgtgttc cctctggctc cttgtagccg gtccacctcc      420

gagtccacag ctgctctggg ctgcctcgtg aaggactact ttcccgaacc cgttaccgtg      480

agctggaata gcggcgcttt aacctccgga gtgcacacct tccccgctgt gctccagtcc      540

tccggtttat actctttatc ctccgtggtg accgtgcctt cctccagcct cggcaccaag      600

acctacactt gtaacgtgga ccacaagccc agcaacacca aggtggacaa gagggtggag      660

tccaagtacg gacctccttg tcccccttgc cccgcccccg aggccgctgg cggaccctcc      720

gtgttcctct tcccccccaa acccaaggac actttaatga tctcccggac ccccgaagtg      780

acttgtgtgg tggtggacgt gtcccaagaa gaccccgagg tgcagtttaa ctggtacgtg      840

gatggcgtgg aggtgcacaa cgccaagacc aagcctaggg aggaacagtt caactccacc      900

taccgggtgg tgtccgtgct caccgtgctg catcaagatt ggctgaacgg caaggagtac      960

aagtgcaagg tgagcaacaa gggactgccc agctccatcg agaagaccat cagcaaggcc     1020

aaaggccagc cccgggaacc tcaagtttat acactgcccc ccagccaaga agagatgacc     1080

aagaaccaag tttctttaac ttgtttagtg aagggcttct accctagcga catcgctgtg     1140

gagtgggagt ccaatggcca gcccgaaaac aattataaga ccaccccccc cgtgctggac     1200

tccgatggtt cttttttttt atactccaag ctgacagtgg acaagtctcg ttggcaagaa     1260

ggcaacgtgt tctcttgtag cgtgatgcac gaggctttac acaaccacta cacccagaag     1320

tctttatctc tgtctttagg ctgatgagaa ttc                                  1353


<210>  119
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  119
caagtgcatc tgcagcagag cggcgctgag ctgatgaagc ccggcgccag cgtgaagatt       60

agctgcaagg ccactggcta cacattcaac atctactgga tcgactgggt gaagcagagg      120

cccggccacg gactggaatg gatcggcgaa attctgcccg gcagcggcaa cactcactac      180

aacgagaact tcaagggcaa ggccacaatg acagccgaca caagctccaa cactgcttac      240

atgcagctga cttctctgac tagcgaggac agcgccgtgt actattgcgc taggacagac      300

ggaaggggct acttcgatta ctggggccaa ggcactacac tcacagtgag cagcgccagc      360

actaagggcc ccagcgtgtt ccctctggct ccttgtagcc ggtccacctc cgagtccaca      420

gctgctctgg gctgcctcgt gaaggactac tttcccgaac ccgttaccgt gagctggaat      480

agcggcgctt taacctccgg agtgcacacc ttccccgctg tgctccagtc ctccggttta      540

tactctttat cctccgtggt gaccgtgcct tcctccagcc tcggcaccaa gacctacact      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agagggtgga gtccaagtac      660

ggacctcctt gtcccccttg ccccgccccc gaggccgctg gcggaccctc cgtgttcctc      720

ttccccccca aacccaagga cactttaatg atctcccgga cccccgaagt gacttgtgtg      780

gtggtggacg tgtcccaaga agaccccgag gtgcagttta actggtacgt ggatggcgtg      840

gaggtgcaca acgccaagac caagcctagg gaggaacagt tcaactccac ctaccgggtg      900

gtgtccgtgc tcaccgtgct gcatcaagat tggctgaacg gcaaggagta caagtgcaag      960

gtgagcaaca agggactgcc cagctccatc gagaagacca tcagcaaggc caaaggccag     1020

ccccgggaac ctcaagttta tacactgccc cccagccaag aagagatgac caagaaccaa     1080

gtttctttaa cttgtttagt gaagggcttc taccctagcg acatcgctgt ggagtgggag     1140

tccaatggcc agcccgaaaa caattataag accacccccc ccgtgctgga ctccgatggt     1200

tctttttttt tatactccaa gctgacagtg gacaagtctc gttggcaaga aggcaacgtg     1260

ttctcttgta gcgtgatgca cgaggcttta cacaaccact acacccagaa gtctttatct     1320

ctgtctttag gctgatgaga attc                                            1344


<210>  120
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  120
caggtgcagc tgcagcagtc cggcgctgag ctcatgaagc ccggcgccag cgtgaagatc       60

agctgcaagg ccactggcta cacattcagc agctactgga tcgagtgggt gaagcagaga      120

cccggccacg gactggaatg gctgggagag tttctgccta gaagcggcaa gacaaactac      180

aacgaggagt ttaggggcaa ggctacattc actgccgaca catccagcaa cactgcctac      240

atgcagctga gcagcctcac aagcgaggat tccgccgtct actactgtgc taggactgat      300

cctccttact tcggagtgtg gggcgctggc acaatggtgg ctgtgagcag cgcctccact      360

aagggcccca gcgtgttccc tctggctcct tgtagccggt ccacctccga gtccacagct      420

gctctgggct gcctcgtgaa ggactacttt cccgaacccg ttaccgtgag ctggaatagc      480

ggcgctttaa cctccggagt gcacaccttc cccgctgtgc tccagtcctc cggtttatac      540

tctttatcct ccgtggtgac cgtgccttcc tccagcctcg gcaccaagac ctacacttgt      600

aacgtggacc acaagcccag caacaccaag gtggacaaga gggtggagtc caagtacgga      660

cctccttgtc ccccttgccc cgcccccgag gccgctggcg gaccctccgt gttcctcttc      720

ccccccaaac ccaaggacac tttaatgatc tcccggaccc ccgaagtgac ttgtgtggtg      780

gtggacgtgt cccaagaaga ccccgaggtg cagtttaact ggtacgtgga tggcgtggag      840

gtgcacaacg ccaagaccaa gcctagggag gaacagttca actccaccta ccgggtggtg      900

tccgtgctca ccgtgctgca tcaagattgg ctgaacggca aggagtacaa gtgcaaggtg      960

agcaacaagg gactgcccag ctccatcgag aagaccatca gcaaggccaa aggccagccc     1020

cgggaacctc aagtttatac actgcccccc agccaagaag agatgaccaa gaaccaagtt     1080

tctttaactt gtttagtgaa gggcttctac cctagcgaca tcgctgtgga gtgggagtcc     1140

aatggccagc ccgaaaacaa ttataagacc accccccccg tgctggactc cgatggttct     1200

ttttttttat actccaagct gacagtggac aagtctcgtt ggcaagaagg caacgtgttc     1260

tcttgtagcg tgatgcacga ggctttacac aaccactaca cccagaagtc tttatctctg     1320

tctttaggct gatgagaatt c                                               1341


<210>  121
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  121
cagatcgtgc tgagccagag cccagctatt ctgtccgcca gccccggcga gaaggtgact       60

atgacttgta gggccagctc cagcatcagc tacatgcact ggtaccagca gaagcccggc      120

tcctccccaa agccttggat cagcgccact agcaatctgg ccagcggcgt gccagccaga      180

ttcagcggaa gcggcagcgg cactagctac tctctgacta tctccggcgt ggaagctgag      240

gatgccgcca cttactactg ccagcagtgg tccagcaacc ctcctacttt cggcggcggc      300

acaaatctgg agatcaagcg gaccgtggct gccccctccg tgttcatctt ccccccttcc      360

gacgagcagc tgaagtccgg caccgctagc gtggtgtgtt tactgaacaa cttctaccct      420

cgtgaggcca aggtgcagtg gaaggtggac aacgctttac agtccggcaa ctcccaagaa      480

tccgtgaccg agcaagattc caaggactcc acctactctt tatcctccac tttaacttta      540

tccaaggccg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca tcaaggttta      600

tcctcccccg tgaccaagtc cttcaatcgt ggcgagtgct gatgagaatt c               651


<210>  122
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  122
agcatcgtca tgacacaaag ccctaagagc atgagcatga gcgtgggcga gagagtgact       60

ctgagctgta aggccagcga gaatgtgggc ggctacgtga gctggtatca gcagaagcca      120

gatcagagcc caaagctgct gatctacggc gccagcagca gacacactgg cgtgccagat      180

aggttcactg gcagcggctc cgagacagac ttcactctga ctatcagcag cgtccaagcc      240

gaagatctgg ccgcctatca ctgcggccag aactacatct acccattcac attcggcggc      300

ggcacaaagc tggagatcaa gcggaccgtg gctgccccct ccgtgttcat cttcccccct      360

tccgacgagc agctgaagtc cggcaccgct agcgtggtgt gtttactgaa caacttctac      420

cctcgtgagg ccaaggtgca gtggaaggtg gacaacgctt tacagtccgg caactcccaa      480

gaatccgtga ccgagcaaga ttccaaggac tccacctact ctttatcctc cactttaact      540

ttatccaagg ccgactacga gaagcacaag gtgtacgctt gtgaggtgac ccatcaaggt      600

ttatcctccc ccgtgaccaa gtccttcaat cgtggcgagt gctgatgaga attc            654


<210>  123
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  123
caagccgtcg tgacacaaga gtccgctctg acaacttccc ccggcgagac tgtgacactg       60

acttgtagga gcagcactgg cgccgtgact atcagcaact acgccaactg ggtccaagag      120

aagccagatc atctgttcac tggactgatc ggcggcacaa ataataggcc tcccggcgtg      180

ccagccagat ttagcggctc tctgattggc gataaggctg ctctgacaat cactggcgcc      240

cagactgagg acgaggccat ctacttctgc gtcctctggt acagcaacca ctgggtgttc      300

ggcggcggca ctaagctgac tgtgctgcgg accgtggctg ccccctccgt gttcatcttc      360

cccccttccg acgagcagct gaagtccggc accgctagcg tggtgtgttt actgaacaac      420

ttctaccctc gtgaggccaa ggtgcagtgg aaggtggaca acgctttaca gtccggcaac      480

tcccaagaat ccgtgaccga gcaagattcc aaggactcca cctactcttt atcctccact      540

ttaactttat ccaaggccga ctacgagaag cacaaggtgt acgcttgtga ggtgacccat      600

caaggtttat cctcccccgt gaccaagtcc ttcaatcgtg gcgagtgctg atgagaattc      660


<210>  124
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  124
gatatcgtca tgactcaagc cgccttcagc actccagtca ctctcggcac aagcgccagc       60

atcagctgta ggtccagcca gtctctgctg cacagcaacg gcatcactta tctgtactgg      120

tatctgcaga agcccggcca aagcccacag ctgctgatct accagatgag caatctggcc      180

agcggcgtgc cagatagatt cagcagcagc ggaagcggaa cagacttcac actgaggatc      240

tctagggtgg aagccgaaga tgtgggcgtc tattactgcg cccagaacct cgagttccct      300

ttcacattcg gcagcggcac taagctggag atcaagcgga ccgtggctgc cccctccgtg      360

ttcatcttcc ccccttccga cgagcagctg aagtccggca ccgctagcgt ggtgtgttta      420

ctgaacaact tctaccctcg tgaggccaag gtgcagtgga aggtggacaa cgctttacag      480

tccggcaact cccaagaatc cgtgaccgag caagattcca aggactccac ctactcttta      540

tcctccactt taactttatc caaggccgac tacgagaagc acaaggtgta cgcttgtgag      600

gtgacccatc aaggtttatc ctcccccgtg accaagtcct tcaatcgtgg cgagtgctga      660

tgagaattc                                                              669


<210>  125
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  125
cagatcgtgc tgacacagag cccagctctg atgagcgcca gccccggcga gaaggtcaca       60

atgacttgca gcgccacatc cagcgtgagc tacatctact ggtaccagca gaagcctagg      120

agcagcccta agccttggat ctacctcaca agcaatctgg ccagcggagt gccagctagg      180

ttcagcggaa gcggcagcgg cacaagctac tctctgacaa tctccagcat ggaagccgaa      240

gatgccgcca cttactactg ccagcagtgg agcagcaatc cacctacatt cggaggcggc      300

actaagctgg agatcaagcg gaccgtggct gccccctccg tgttcatctt ccccccttcc      360

gacgagcagc tgaagtccgg caccgctagc gtggtgtgtt tactgaacaa cttctaccct      420

cgtgaggcca aggtgcagtg gaaggtggac aacgctttac agtccggcaa ctcccaagaa      480

tccgtgaccg agcaagattc caaggactcc acctactctt tatcctccac tttaacttta      540

tccaaggccg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca tcaaggttta      600

tcctcccccg tgaccaagtc cttcaatcgt ggcgagtgct gatgagaatt c               651


<210>  126
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  126
gatatcgtga tgactcagtc cccagccatc atgtccgcca gccccggcga gaaggtgact       60

atgacttgct ccgccagcag cagcgtgagc tacatgcact ggtaccagca gaagagcggc      120

acatccccaa agaggtggat ctacgacaca agcaagctgg ccagcggcgt gccagccaga      180

ttcagcggct ccggcagcgg aacaagctac tctctgacta tcagcagcat ggagacagag      240

gacgctgcca cttactactg ccagcagtgg agcagcaatc ctccaacttt cggcggaggc      300

actaagctgg agctgaagcg gaccgtggct gccccctccg tgttcatctt ccccccttcc      360

gacgagcagc tgaagtccgg caccgctagc gtggtgtgtt tactgaacaa cttctaccct      420

cgtgaggcca aggtgcagtg gaaggtggac aacgctttac agtccggcaa ctcccaagaa      480

tccgtgaccg agcaagattc caaggactcc acctactctt tatcctccac tttaacttta      540

tccaaggccg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca tcaaggttta      600

tcctcccccg tgaccaagtc cttcaatcgt ggcgagtgct gatgagaatt c               651


<210>  127
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  127
cagattgtgc tgtcccagtc cccagccatt ctgagcgcca gccccggcga gaaggtgact       60

atgacttgta gggccacaag cagcgtgagc tacatgtact ggtaccagca gaagcccggc      120

agcagcccta agccttggat ctacgccaca agcaatctgg ccagcggcgt cccagctaga      180

tttagcggca gcggatccgg cactagctat tctctgacta tctctagggt cgaggccgaa      240

gatgccgcca catactactg ccagcagtgg tcctccaatc ctccaacatt cggcggcgga      300

actaagctgg agaagaagag gacagtggct gccccttccg tgttcatctt ccctccaagc      360

gacgagcagc tgaagtccgg cactgctagc gtggtgtgtt tactgaacaa cttctaccct      420

cgtgaggcca aggtgcagtg gaaggtggac aacgctttac agtccggcaa ctcccaagaa      480

tccgtgaccg agcaagattc caaggactcc acctactctt tatcctccac tttaacttta      540

tccaaggccg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca tcaaggttta      600

tcctcccccg tgaccaagtc cttcaatcgt ggcgagtgct gatgagaatt c               651


<210>  128
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  128
gatatcgtgc tgactcagag cccagcctct ctggtggtgt ctctgggaca gagggccaca       60

atcagctgta ggacttccaa gagcgtgagc agctccgcct acagctacat gcactggtac      120

cagcagaagc ccggccagcc tcctaaggtg ctgatctatc tggccagcaa tctggagagc      180

ggcgtcccag ctagattcag cggctccgga agcggcactg acttcactct gaacatccac      240

ccagtggaag aggaggatgc cgccacatac tactgccagc actctaggga gctgcctttc      300

acatttggca gcggaactaa gctggagatc aagaggactg tcgccgcccc tagcgtgttc      360

atcttccctc caagcgatga gcagctgaag agcggcactg ctagcgtggt gtgtttactg      420

aacaacttct accctcgtga ggccaaggtg cagtggaagg tggacaacgc tttacagtcc      480

ggcaactccc aagaatccgt gaccgagcaa gattccaagg actccaccta ctctttatcc      540

tccactttaa ctttatccaa ggccgactac gagaagcaca aggtgtacgc ttgtgaggtg      600

acccatcaag gtttatcctc ccccgtgacc aagtccttca atcgtggcga gtgctgatga      660

gaattc                                                                 666


<210>  129
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  129
caaattgttc tcacacagag ccctcctatc atgagcgcca gccccggcga gaaggtgact       60

atgacttgtt ccgccagcag caacatcagc tacatgcact ggtaccagca gaagtccggc      120

acaagcccaa agaggtggat ctacgacaca agcaagctgg ccagcggcgt gccagccaga      180

tttagcggct ccggaagcgg cactagctac tctctgacaa tcagcagcat ggaagccgag      240

gacgccgcta catactactg ccagcagtgg agctccgtcc cactgacttt cggcgctggc      300

actaagctgg agatcaagag gactgtggcc gccccttccg tgttcatctt ccctcctagc      360

gacgaacagc tcaagagcgg cactgctagc gtggtgtgtt tactgaacaa cttctaccct      420

cgtgaggcca aggtgcagtg gaaggtggac aacgctttac agtccggcaa ctcccaagaa      480

tccgtgaccg agcaagattc caaggactcc acctactctt tatcctccac tttaacttta      540

tccaaggccg actacgagaa gcacaaggtg tacgcttgtg aggtgaccca tcaaggttta      600

tcctcccccg tgaccaagtc cttcaatcgt ggcgagtgct gatgagaatt c               651


<210>  130
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  130
cagatcgtgc tgagccagag cccagctatt ctgtccgcca gccccggcga gaaggtgact       60

atgacttgta gggccagctc cagcatcagc tacatgcact ggtaccagca gaagcccggc      120

tcctccccaa agccttggat cagcgccact agcaatctgg ccagcggcgt gccagccaga      180

ttcagcggaa gcggcagcgg cactagctac tctctgacta tctccggcgt ggaagctgag      240

gatgccgcca cttactactg ccagcagtgg tccagcaacc ctcctacttt cggcggcggc      300

acaaatctgg agatcaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      360

tctgaagtgc tgctgcagca gagcggacca gagctggtca agcccggcgc ctccatgaag      420

atcagctgta aggcctccgt gtacagcttc acagcctaca caatgaactg ggtgaagcag      480

agccacggca agaatctgga gtggatcgga ctgatcaacc cacacaatgg cggcactagg      540

tacaaccaga agttcaaggg caaggccaca ctgactctgg ataagtccag cagcactgcc      600

tacatggatc tgctgtctct gacaagcgag gacagcgccg tctactattg cgccatctct      660

aggtacggca gcagcagctt ctacttcgat gtgtggggcg ccggcacaac agtggctgtg      720

agcagc                                                                 726


<210>  131
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  131
gaagtgctgc tgcagcagag cggaccagag ctggtcaagc ccggcgcctc catgaagatc       60

agctgtaagg cctccgtgta cagcttcaca gcctacacaa tgaactgggt gaagcagagc      120

cacggcaaga atctggagtg gatcggactg atcaacccac acaatggcgg cactaggtac      180

aaccagaagt tcaagggcaa ggccacactg actctggata agtccagcag cactgcctac      240

atggatctgc tgtctctgac aagcgaggac agcgccgtct actattgcgc catctctagg      300

tacggcagca gcagcttcta cttcgatgtg tggggcgccg gcacaacagt ggctgtgagc      360

agcggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctca gatcgtgctg      420

agccagagcc cagctattct gtccgccagc cccggcgaga aggtgactat gacttgtagg      480

gccagctcca gcatcagcta catgcactgg taccagcaga agcccggctc ctccccaaag      540

ccttggatca gcgccactag caatctggcc agcggcgtgc cagccagatt cagcggaagc      600

ggcagcggca ctagctactc tctgactatc tccggcgtgg aagctgagga tgccgccact      660

tactactgcc agcagtggtc cagcaaccct cctactttcg gcggcggcac aaatctggag      720

atcaag                                                                 726


<210>  132
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  132
agcatcgtca tgacacaaag ccctaagagc atgagcatga gcgtgggcga gagagtgact       60

ctgagctgta aggccagcga gaatgtgggc ggctacgtga gctggtatca gcagaagcca      120

gatcagagcc caaagctgct gatctacggc gccagcagca gacacactgg cgtgccagat      180

aggttcactg gcagcggctc cgagacagac ttcactctga ctatcagcag cgtccaagcc      240

gaagatctgg ccgcctatca ctgcggccag aactacatct acccattcac attcggcggc      300

ggcacaaagc tggagatcaa gggtggcggt ggctcgggcg gtggtgggtc gggtggcggc      360

ggatctcaag tgcagctcca gcagagcgga gctgagctgg tgagacccgg cactagcgtg      420

aagatcagct gtaaggccag cggctacgcc ttcactaatt actggctggg ctggatgaag      480

cagagacccg gccatggact ggagtggatc ggcgacttct acccaaggac tggcaacact      540

ttctacaacg agaactttaa gggcaaggtg actctgactg ccgataagtc cagcaacact      600

gcctacatgc agctgtcctc tctgactagc gaagatagcg ccgtgtatct gtgtgctagg      660

gctggcactg gcttcgatta ctggggccaa ggcacaacac tgacagtgag cagc            714


<210>  133
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  133
caagtgcagc tccagcagag cggagctgag ctggtgagac ccggcactag cgtgaagatc       60

agctgtaagg ccagcggcta cgccttcact aattactggc tgggctggat gaagcagaga      120

cccggccatg gactggagtg gatcggcgac ttctacccaa ggactggcaa cactttctac      180

aacgagaact ttaagggcaa ggtgactctg actgccgata agtccagcaa cactgcctac      240

atgcagctgt cctctctgac tagcgaagat agcgccgtgt atctgtgtgc tagggctggc      300

actggcttcg attactgggg ccaaggcaca acactgacag tgagcagcgg tggcggtggc      360

tcgggcggtg gtgggtcggg tggcggcgga tctagcatcg tcatgacaca aagccctaag      420

agcatgagca tgagcgtggg cgagagagtg actctgagct gtaaggccag cgagaatgtg      480

ggcggctacg tgagctggta tcagcagaag ccagatcaga gcccaaagct gctgatctac      540

ggcgccagca gcagacacac tggcgtgcca gataggttca ctggcagcgg ctccgagaca      600

gacttcactc tgactatcag cagcgtccaa gccgaagatc tggccgccta tcactgcggc      660

cagaactaca tctacccatt cacattcggc ggcggcacaa agctggagat caag            714


<210>  134
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  134
caagccgtcg tgacacaaga gtccgctctg acaacttccc ccggcgagac tgtgacactg       60

acttgtagga gcagcactgg cgccgtgact atcagcaact acgccaactg ggtccaagag      120

aagccagatc atctgttcac tggactgatc ggcggcacaa ataataggcc tcccggcgtg      180

ccagccagat ttagcggctc tctgattggc gataaggctg ctctgacaat cactggcgcc      240

cagactgagg acgaggccat ctacttctgc gtcctctggt acagcaacca ctgggtgttc      300

ggcggcggca ctaagctgac tgtgctgggt ggcggtggct cgggcggtgg tgggtcgggt      360

ggcggcggat ctcaagtgca gctgcagcag agcggcgctg agctgatgaa gcccggcgct      420

tccgtcaaga tcagctgcaa gactactggc tataggttca gcagctactg gatcgagtgg      480

gtgaagcaga gacccggcca cggactggaa tggctgggcg aaatcctccc cggaaggggc      540

atcatcaact acaatgagaa ctttaggggc aaggccacat tcacagccga cacaagcagc      600

aacactgcct acgtgcagct gagctctctg acttccgagg acagcgccgt gtacttctgc      660

gccagaacag accctcctta tttcggcgtg tggggcgccg gaactactgt gactgtgtcc      720

agc                                                                    723


<210>  135
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  135
caagtgcagc tgcagcagag cggcgctgag ctgatgaagc ccggcgcttc cgtcaagatc       60

agctgcaaga ctactggcta taggttcagc agctactgga tcgagtgggt gaagcagaga      120

cccggccacg gactggaatg gctgggcgaa atcctccccg gaaggggcat catcaactac      180

aatgagaact ttaggggcaa ggccacattc acagccgaca caagcagcaa cactgcctac      240

gtgcagctga gctctctgac ttccgaggac agcgccgtgt acttctgcgc cagaacagac      300

cctccttatt tcggcgtgtg gggcgccgga actactgtga ctgtgtccag cggtggcggt      360

ggctcgggcg gtggtgggtc gggtggcggc ggatctcaag ccgtcgtgac acaagagtcc      420

gctctgacaa cttcccccgg cgagactgtg acactgactt gtaggagcag cactggcgcc      480

gtgactatca gcaactacgc caactgggtc caagagaagc cagatcatct gttcactgga      540

ctgatcggcg gcacaaataa taggcctccc ggcgtgccag ccagatttag cggctctctg      600

attggcgata aggctgctct gacaatcact ggcgcccaga ctgaggacga ggccatctac      660

ttctgcgtcc tctggtacag caaccactgg gtgttcggcg gcggcactaa gctgactgtg      720

ctg                                                                    723


<210>  136
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  136
gatatcgtca tgactcaagc cgccttcagc actccagtca ctctcggcac aagcgccagc       60

atcagctgta ggtccagcca gtctctgctg cacagcaacg gcatcactta tctgtactgg      120

tatctgcaga agcccggcca aagcccacag ctgctgatct accagatgag caatctggcc      180

agcggcgtgc cagatagatt cagcagcagc ggaagcggaa cagacttcac actgaggatc      240

tctagggtgg aagccgaaga tgtgggcgtc tattactgcg cccagaacct cgagttccct      300

ttcacattcg gcagcggcac taagctggag atcaagggtg gcggtggctc gggcggtggt      360

gggtcgggtg gcggcggatc tcaagtgcag ctgcagcaga gcggagccga gctgatgaag      420

cccggcgcct ccatgaagat cagctgcaag gccactggct acacattcag cacatactgg      480

atcgagtggg tcaagcagag acccggccac ggactggagt ggatcggaga gaatctgccc      540

ggaaggcaca tcactaacta caacgagaag ttcaagggca aggccacttt cacagccgac      600

actagcagca acactgccta catgcagctc agctctctga caagcgaaga tagcgccgtg      660

tactactgtg ctaggggaag gggcacttac tacttcgatt actggggcca aggcactcca      720

ctgactgtgt ccagc                                                       735


<210>  137
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  137
caagtgcagc tgcagcagag cggagccgag ctgatgaagc ccggcgcctc catgaagatc       60

agctgcaagg ccactggcta cacattcagc acatactgga tcgagtgggt caagcagaga      120

cccggccacg gactggagtg gatcggagag aatctgcccg gaaggcacat cactaactac      180

aacgagaagt tcaagggcaa ggccactttc acagccgaca ctagcagcaa cactgcctac      240

atgcagctca gctctctgac aagcgaagat agcgccgtgt actactgtgc taggggaagg      300

ggcacttact acttcgatta ctggggccaa ggcactccac tgactgtgtc cagcggtggc      360

ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg atatcgtcat gactcaagcc      420

gccttcagca ctccagtcac tctcggcaca agcgccagca tcagctgtag gtccagccag      480

tctctgctgc acagcaacgg catcacttat ctgtactggt atctgcagaa gcccggccaa      540

agcccacagc tgctgatcta ccagatgagc aatctggcca gcggcgtgcc agatagattc      600

agcagcagcg gaagcggaac agacttcaca ctgaggatct ctagggtgga agccgaagat      660

gtgggcgtct attactgcgc ccagaacctc gagttccctt tcacattcgg cagcggcact      720

aagctggaga tcaag                                                       735


<210>  138
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  138
cagatcgtgc tgacacagag cccagctctg atgagcgcca gccccggcga gaaggtcaca       60

atgacttgca gcgccacatc cagcgtgagc tacatctact ggtaccagca gaagcctagg      120

agcagcccta agccttggat ctacctcaca agcaatctgg ccagcggagt gccagctagg      180

ttcagcggaa gcggcagcgg cacaagctac tctctgacaa tctccagcat ggaagccgaa      240

gatgccgcca cttactactg ccagcagtgg agcagcaatc cacctacatt cggaggcggc      300

actaagctgg agatcaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      360

tctgaggtgc agctccaaca gagcggacca gagctggtga aacccggcgc cagcatgaag      420

atcagctgta aggcctccgg ctacagcttc actggctaca ctatgaactg ggtgaagcag      480

tcccacggca agaatctgga gtggatcgga ctgatcaacc catacaacgg cggcacaaac      540

tacaaccaga agttcaaggg caaggccact ctgacagtcg ataagagctc cagcactgcc      600

tacatggagc tgctgagcct cactagcgag gacagcgctg tgtactactg tgccttctcc      660

tactacggct ctaggggctt ctacttcgat tactggggcc aaggcacaac actgacagtg      720

tccagc                                                                 726


<210>  139
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  139
gaggtgcagc tccaacagag cggaccagag ctggtgaaac ccggcgccag catgaagatc       60

agctgtaagg cctccggcta cagcttcact ggctacacta tgaactgggt gaagcagtcc      120

cacggcaaga atctggagtg gatcggactg atcaacccat acaacggcgg cacaaactac      180

aaccagaagt tcaagggcaa ggccactctg acagtcgata agagctccag cactgcctac      240

atggagctgc tgagcctcac tagcgaggac agcgctgtgt actactgtgc cttctcctac      300

tacggctcta ggggcttcta cttcgattac tggggccaag gcacaacact gacagtgtcc      360

agcggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctca gatcgtgctg      420

acacagagcc cagctctgat gagcgccagc cccggcgaga aggtcacaat gacttgcagc      480

gccacatcca gcgtgagcta catctactgg taccagcaga agcctaggag cagccctaag      540

ccttggatct acctcacaag caatctggcc agcggagtgc cagctaggtt cagcggaagc      600

ggcagcggca caagctactc tctgacaatc tccagcatgg aagccgaaga tgccgccact      660

tactactgcc agcagtggag cagcaatcca cctacattcg gaggcggcac taagctggag      720

atcaag                                                                 726


<210>  140
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  140
gatatcgtga tgactcagtc cccagccatc atgtccgcca gccccggcga gaaggtgact       60

atgacttgct ccgccagcag cagcgtgagc tacatgcact ggtaccagca gaagagcggc      120

acatccccaa agaggtggat ctacgacaca agcaagctgg ccagcggcgt gccagccaga      180

ttcagcggct ccggcagcgg aacaagctac tctctgacta tcagcagcat ggagacagag      240

gacgctgcca cttactactg ccagcagtgg agcagcaatc ctccaacttt cggcggaggc      300

actaagctgg agctgaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      360

tctgaagtgc agctgcaaca gagcggccca gagctcgtga agcccggcgc cagcatgaag      420

atcagctgca aggccagcgg ctacagcttc actggctaca caatgaactg ggtcaagcag      480

agccacggaa aaaatctgga gtggatcgga ctgatcaacc cttacaacgg cggcacaagg      540

tacaatcaga agttcaaggg caaggccact ctcactgtgg ataagagcag cagcactgcc      600

tacatggagc tgctgtctct gacaagcgag gatagcgccg tgtactactg cgccagctcc      660

tcctatagga acgacggcaa ctggtacttc gatgtgtggg gcgccggcac tactgtgaca      720

gtgagctcc                                                              729


<210>  141
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  141
gaagtgcagc tgcaacagag cggcccagag ctcgtgaagc ccggcgccag catgaagatc       60

agctgcaagg ccagcggcta cagcttcact ggctacacaa tgaactgggt caagcagagc      120

cacggaaaaa atctggagtg gatcggactg atcaaccctt acaacggcgg cacaaggtac      180

aatcagaagt tcaagggcaa ggccactctc actgtggata agagcagcag cactgcctac      240

atggagctgc tgtctctgac aagcgaggat agcgccgtgt actactgcgc cagctcctcc      300

tataggaacg acggcaactg gtacttcgat gtgtggggcg ccggcactac tgtgacagtg      360

agctccggtg gcggtggctc gggcggtggt gggtcgggtg gcggcggatc tgatatcgtg      420

atgactcagt ccccagccat catgtccgcc agccccggcg agaaggtgac tatgacttgc      480

tccgccagca gcagcgtgag ctacatgcac tggtaccagc agaagagcgg cacatcccca      540

aagaggtgga tctacgacac aagcaagctg gccagcggcg tgccagccag attcagcggc      600

tccggcagcg gaacaagcta ctctctgact atcagcagca tggagacaga ggacgctgcc      660

acttactact gccagcagtg gagcagcaat cctccaactt tcggcggagg cactaagctg      720

gagctgaag                                                              729


<210>  142
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  142
cagattgtgc tgtcccagtc cccagccatt ctgagcgcca gccccggcga gaaggtgact       60

atgacttgta gggccacaag cagcgtgagc tacatgtact ggtaccagca gaagcccggc      120

agcagcccta agccttggat ctacgccaca agcaatctgg ccagcggcgt cccagctaga      180

tttagcggca gcggatccgg cactagctat tctctgacta tctctagggt cgaggccgaa      240

gatgccgcca catactactg ccagcagtgg tcctccaatc ctccaacatt cggcggcgga      300

actaagctgg agaagaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      360

tctgaagtgc agctgcagca gagcggacca gagctggtca agcccggcgc cagcatgaag      420

atcagctgta aggccagcgg ctacagcatc actggctaca ctatgaactg ggtgaagcag      480

agccacggca agaacctcga gtggattggc ctcgtgaacc catacaacgg cggcacttcc      540

tacaaccaga agttcaaagg caaggccaca ctcacagtcg ataagtccag ctccacagcc      600

tacatggagc tgctgtctct gaagagcgag gatagcgctg tctactactg tgccatcagc      660

agatacggca gcgagagctg gtacttcgac gtgtggggcg ccggcacaac agtgacagtg      720

agcagc                                                                 726


<210>  143
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  143
gaagtgcagc tgcagcagag cggaccagag ctggtcaagc ccggcgccag catgaagatc       60

agctgtaagg ccagcggcta cagcatcact ggctacacta tgaactgggt gaagcagagc      120

cacggcaaga acctcgagtg gattggcctc gtgaacccat acaacggcgg cacttcctac      180

aaccagaagt tcaaaggcaa ggccacactc acagtcgata agtccagctc cacagcctac      240

atggagctgc tgtctctgaa gagcgaggat agcgctgtct actactgtgc catcagcaga      300

tacggcagcg agagctggta cttcgacgtg tggggcgccg gcacaacagt gacagtgagc      360

agcggtggcg gtggctcggg cggtggtggg tcgggtggcg gcggatctca gattgtgctg      420

tcccagtccc cagccattct gagcgccagc cccggcgaga aggtgactat gacttgtagg      480

gccacaagca gcgtgagcta catgtactgg taccagcaga agcccggcag cagccctaag      540

ccttggatct acgccacaag caatctggcc agcggcgtcc cagctagatt tagcggcagc      600

ggatccggca ctagctattc tctgactatc tctagggtcg aggccgaaga tgccgccaca      660

tactactgcc agcagtggtc ctccaatcct ccaacattcg gcggcggaac taagctggag      720

aagaag                                                                 726


<210>  144
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  144
gatatcgtgc tgactcagag cccagcctct ctggtggtgt ctctgggaca gagggccaca       60

atcagctgta ggacttccaa gagcgtgagc agctccgcct acagctacat gcactggtac      120

cagcagaagc ccggccagcc tcctaaggtg ctgatctatc tggccagcaa tctggagagc      180

ggcgtcccag ctagattcag cggctccgga agcggcactg acttcactct gaacatccac      240

ccagtggaag aggaggatgc cgccacatac tactgccagc actctaggga gctgcctttc      300

acatttggca gcggaactaa gctggagatc aagggtggcg gtggctcggg cggtggtggg      360

tcgggtggcg gcggatctca agtgcatctg cagcagagcg gcgctgagct gatgaagccc      420

ggcgccagcg tgaagattag ctgcaaggcc actggctaca cattcaacat ctactggatc      480

gactgggtga agcagaggcc cggccacgga ctggaatgga tcggcgaaat tctgcccggc      540

agcggcaaca ctcactacaa cgagaacttc aagggcaagg ccacaatgac agccgacaca      600

agctccaaca ctgcttacat gcagctgact tctctgacta gcgaggacag cgccgtgtac      660

tattgcgcta ggacagacgg aaggggctac ttcgattact ggggccaagg cactacactc      720

acagtgagca gc                                                          732


<210>  145
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  145
caagtgcatc tgcagcagag cggcgctgag ctgatgaagc ccggcgccag cgtgaagatt       60

agctgcaagg ccactggcta cacattcaac atctactgga tcgactgggt gaagcagagg      120

cccggccacg gactggaatg gatcggcgaa attctgcccg gcagcggcaa cactcactac      180

aacgagaact tcaagggcaa ggccacaatg acagccgaca caagctccaa cactgcttac      240

atgcagctga cttctctgac tagcgaggac agcgccgtgt actattgcgc taggacagac      300

ggaaggggct acttcgatta ctggggccaa ggcactacac tcacagtgag cagcggtggc      360

ggtggctcgg gcggtggtgg gtcgggtggc ggcggatctg atatcgtgct gactcagagc      420

ccagcctctc tggtggtgtc tctgggacag agggccacaa tcagctgtag gacttccaag      480

agcgtgagca gctccgccta cagctacatg cactggtacc agcagaagcc cggccagcct      540

cctaaggtgc tgatctatct ggccagcaat ctggagagcg gcgtcccagc tagattcagc      600

ggctccggaa gcggcactga cttcactctg aacatccacc cagtggaaga ggaggatgcc      660

gccacatact actgccagca ctctagggag ctgcctttca catttggcag cggaactaag      720

ctggagatca ag                                                          732


<210>  146
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  146
caaattgttc tcacacagag ccctcctatc atgagcgcca gccccggcga gaaggtgact       60

atgacttgtt ccgccagcag caacatcagc tacatgcact ggtaccagca gaagtccggc      120

acaagcccaa agaggtggat ctacgacaca agcaagctgg ccagcggcgt gccagccaga      180

tttagcggct ccggaagcgg cactagctac tctctgacaa tcagcagcat ggaagccgag      240

gacgccgcta catactactg ccagcagtgg agctccgtcc cactgacttt cggcgctggc      300

actaagctgg agatcaaggg tggcggtggc tcgggcggtg gtgggtcggg tggcggcgga      360

tctcaggttc agctgcagca gtccggcgct gagctcatga agcccggcgc cagcgtgaag      420

atcagctgca aggccactgg ctacacattc agcagctact ggatcgagtg ggtgaagcag      480

agacccggcc acggactgga atggctggga gagtttctgc ctagaagcgg caagacaaac      540

tacaacgagg agtttagggg caaggctaca ttcactgccg acacatccag caacactgcc      600

tacatgcagc tgagcagcct cacaagcgag gattccgccg tctactactg tgctaggact      660

gatcctcctt acttcggagt gtggggcgct ggcacaatgg tggctgtgag cagc            714


<210>  147
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleic acid molecule

<400>  147
caggttcagc tgcagcagtc cggcgctgag ctcatgaagc ccggcgccag cgtgaagatc       60

agctgcaagg ccactggcta cacattcagc agctactgga tcgagtgggt gaagcagaga      120

cccggccacg gactggaatg gctgggagag tttctgccta gaagcggcaa gacaaactac      180

aacgaggagt ttaggggcaa ggctacattc actgccgaca catccagcaa cactgcctac      240

atgcagctga gcagcctcac aagcgaggat tccgccgtct actactgtgc taggactgat      300

cctccttact tcggagtgtg gggcgctggc acaatggtgg ctgtgagcag cggtggcggt      360

ggctcgggcg gtggtgggtc gggtggcggc ggatctcaaa ttgttctcac acagagccct      420

cctatcatga gcgccagccc cggcgagaag gtgactatga cttgttccgc cagcagcaac      480

atcagctaca tgcactggta ccagcagaag tccggcacaa gcccaaagag gtggatctac      540

gacacaagca agctggccag cggcgtgcca gccagattta gcggctccgg aagcggcact      600

agctactctc tgacaatcag cagcatggaa gccgaggacg ccgctacata ctactgccag      660

cagtggagct ccgtcccact gactttcggc gctggcacta agctggagat caag            714


<210>  148
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Constant region of human IgG4

<400>  148

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  149
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of tanezumab

<400>  149

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Phe His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Glu His Thr Leu Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  150
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of tanezumab

<400>  150

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Gly Tyr 
            20                  25                  30          


Asp Leu Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ile Ile Trp Gly Asp Gly Thr Thr Asp Tyr Asn Ser Ala Val Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Tyr Trp Tyr Ala Thr Ser Tyr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  151
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain of MNAC13

<400>  151

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  152
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain of MNAC13

<400>  152

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Thr Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Lys Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Met Phe Gly Asn Asp Phe Phe Phe Pro Met Asp Arg 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


