                         SEQUENCE LISTING

<110>  UTI LIMITED PARTNERSHIP
       Santamaria, Pedro
 
<120>  METHODS OF TREATING LIVER DISEASE

<130>  PTI0017-401-PC

<140>  PCT/US2020/034239
<141>  2020-05-22

<150>  US 62/852,194
<151>  2019-05-23

<160>  105   

<170>  PatentIn version 3.5

<210>  1
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu 
1               5                   10                  15  


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Leu Leu Leu Gln Leu Leu Gly Ser Pro Gly Arg Arg Tyr Tyr 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala Gln Arg Leu 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Arg Val Phe Val Ser Pro Leu Ala Lys Lys Leu Ala Val Glu 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Homo sapients

<400>  5

Ser Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Thr Ile Ala Asn Asp Val Val Ser Leu Ala Thr Lys Ala Arg 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Gln Trp Leu Ala Glu Phe Arg Lys Tyr Leu Glu Lys Pro Ile 
1               5                   10                  15  


<210>  8
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Asp Leu Ile Ala Glu Val Glu Thr Asp Lys Ala Thr Val 
1               5                   10                  


<210>  9
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Asp Leu Leu Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile 
1               5                   10                  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Asp Leu Leu Ala Glu Ile Glu Thr Asp Lys Ala Thr Ile Gly 
1               5                   10                  15  


<210>  11
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Ile Pro Ile Ser Asn Ile Arg Arg Val Ile Ala Gln Arg Leu 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Pro Gly Arg Arg Tyr Tyr Ser Leu Pro Pro His Gln Lys Val 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Asn Pro Glu Ser Ser Phe Asn Asp Glu Asn Leu Arg Ile Val 
1               5                   10                  15  


<210>  14
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Phe Asn Asp Glu Asn Leu Arg Ile Val Val Ala Asp Leu Phe 
1               5                   10                  15  


<210>  15
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  15

Leu Leu Leu Met Ile Leu His Pro Asp Val Gln Arg Arg Val Gln 
1               5                   10                  15  


<210>  16
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Leu Ala Trp Gly Leu Leu Leu Met Ile Leu His Pro Asp Val Gln 
1               5                   10                  15      


Arg Arg Val Gln 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  17

Thr Thr Leu Ile Thr Asn Leu Ser Ser Val Leu Lys Asp Glu Ala Val 
1               5                   10                  15      


Trp Glu Lys Pro 
            20  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Leu Val Pro Leu Ala Val Ile Val Ala Ile Phe Leu Leu Leu 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  20

Glu Asn Leu Arg Ile Val Val Ala Asp Leu Phe Ser Ala Gly Met 
1               5                   10                  15  


<210>  21
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Leu Arg Glu Val Leu Asn Ala Val Pro Val Leu Leu His Ile 
1               5                   10                  15  


<210>  22
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Gly Lys Val Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu 
1               5                   10                  15  


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Phe Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg Trp 
1               5                   10                  15  


<210>  24
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Leu Ala Gly Lys Val Leu Arg Phe Gln Lys Ala Phe Leu Thr 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Leu Leu Leu Met Ile Leu His Pro Asp Val Gln Arg Arg Val 
1               5                   10                  15  


<210>  26
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Asn Leu Arg Ile Val Val Ala Asp Leu Phe Ser Ala Gly Met 
1               5                   10                  15  


<210>  27
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  27

Val Lys Pro Glu Ala Phe Leu Pro Phe Ser Ala Gly Arg Arg Ala 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  28

Ala Gly Lys Val Leu Arg Phe Gln Lys Ala Phe Leu Thr Gln Leu 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Ile Phe Leu Leu Leu Val Asp Leu Met His Arg Arg Gln Arg 
1               5                   10                  15  


<210>  30
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  30

Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu Ala Gln Glu Gly Leu 
1               5                   10                  15  


<210>  31
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Met Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe 
1               5                   10                  15  


<210>  32
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  32

Asp Leu Phe Ser Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Leu Phe Leu Phe Phe Thr Ser Leu Leu Gln His Phe Ser Phe 
1               5                   10                  15  


<210>  34
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Gln Leu Arg Arg Arg Phe Gly Asp Val Phe Ser Leu Gln Leu 
1               5                   10                  15  


<210>  35
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  35

Glu Gln Arg Arg Phe Ser Val Ser Thr Leu Arg Asn Leu Gly Leu 
1               5                   10                  15  


<210>  36
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Arg Phe Glu Tyr Asp Asp Pro Arg Phe Leu Arg Leu Leu Asp Leu 
1               5                   10                  15      


Ala Gln Glu Gly 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  37

Ala Gly Met Val Thr Thr Ser Thr Thr Leu Ala Trp Gly Leu Leu Leu 
1               5                   10                  15      


Met Ile Leu His 
            20  


<210>  38
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  38

Thr Thr Ala Glu Arg Glu Ile Val Arg Asp Ile Lys Glu Lys Leu 
1               5                   10                  15  


<210>  39
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp 
1               5                   10                  15  


<210>  40
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  40

Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val 
1               5                   10                  15  


<210>  41
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Tyr Leu Met Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Thr 
1               5                   10                  15  


<210>  42
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  42

Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr 
1               5                   10                  15  


<210>  43
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  43

Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala Ser 
1               5                   10                  15  


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala Ser 
1               5                   10                  15  


<210>  45
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu 
1               5                   10                  15  


<210>  46
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  46

Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  47

Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu Arg Leu 
1               5                   10                  15  


<210>  48
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Ala Pro Arg Ala Val Phe Pro Ser Ile Val Gly Arg Pro Arg 
1               5                   10                  15  


<210>  49
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys Tyr 
1               5                   10                  15  


<210>  50
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
1               5                   10                  15  


<210>  51
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  51

Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
1               5                   10                  15  


<210>  52
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  52

Leu Pro His Ala Ile Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu 
1               5                   10                  15  


<210>  53
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  53

Tyr Lys Lys Leu Leu Lys Glu Arg Lys Glu Met Phe Ser Tyr Leu 
1               5                   10                  15  


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  54

Asp Glu Leu Arg Thr Asp Leu Lys Ala Val Glu Ala Lys Val Gln 
1               5                   10                  15  


<210>  55
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  55

Asn Lys Ile Thr Asn Ser Leu Val Leu Asp Ile Ile Lys Leu Ala 
1               5                   10                  15  


<210>  56
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  56

Asn Arg Leu Asp Arg Cys Leu Lys Ala Val Arg Lys Glu Arg 
1               5                   10                  


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  57

Leu Ile Gln Gln Gly Ala Arg Val Gly Arg Ile Asp 
1               5                   10          


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Lys Glu Met Phe Ser Tyr Leu Ser Asn Gln Ile Lys Lys Leu Ser 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Ser Ser Leu Leu Asn Lys Ile Thr Asn Ser Leu Val Leu Asp 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Asn Asp Ser Phe Ile Gln Glu Ile Ser Lys Met Tyr Pro Gly Arg 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  61

Ser Thr Leu Glu Leu Phe Leu His Glu Leu Ala Ile Met Asp Ser 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  62

Ser Lys Cys Met His Leu Ile Gln Gln Gly Ala Arg Val Gly Arg 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  63

Asn Ser Leu Val Leu Asp Ile Ile Lys Leu Ala Gly Val His Thr 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  64

Arg Arg His Tyr Arg Phe Ile His Gly Ile Gly Arg Ser Gly Asp 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Ser His Glu His Leu Ile Arg Leu Leu Leu Glu Lys Gly Lys 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  66

Ser Asn Gly Tyr Lys Lys Leu Leu Lys Glu Arg Lys Glu Met Phe 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  67

Ser Pro Ser Leu Asp Val Leu Ile Thr Leu Leu Ser Leu Gly Ser 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  68

Asp Gln Lys Ser Cys Phe Lys Ser Met Ile Thr Ala Gly Phe Glu 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  69

Tyr Thr Phe Arg Gly Phe Met Ser His Thr Asn Asn Tyr Pro Cys 
1               5                   10                  15  


<210>  70
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  70

Tyr Asn Glu Arg Leu Leu His Thr Pro His Asn Pro Ile Ser Leu 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Cys Ile Leu Cys Ile His Ser Thr Thr Ser Cys Phe Ala Pro 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Ser Leu Leu Asn Lys Ile Thr Asn Ser Leu Val Leu Asp Ile 
1               5                   10                  15  


<210>  73
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  73

Ala Leu Gln Glu Gly Leu Arg Arg Ala Val Ser Val Pro Leu Thr 
1               5                   10                  15  


<210>  74
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  74

Arg Arg Gln Phe Gln Ser Leu Asp Thr Thr Met Arg Arg Leu Ile 
1               5                   10                  15  


<210>  75
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  75

Glu Gln Arg Ile Arg Leu Val Val Ser Arg Leu Gly Leu Asp Ser 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  76

Ala Lys Thr Gln Ala Ala Leu Val Leu Asp Cys Leu Glu Thr Arg 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  77

Lys Val Gln Gly Ile Gly Trp Tyr Leu Asp Glu Lys Asn Leu Ala 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  78

Tyr Phe Asn Val Leu Ile Asn Leu Arg Asp Ile Thr Asp Glu Ala 
1               5                   10                  15  


<210>  79
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  79

Leu Pro Val Val Gly Ser Gln Leu Val Gly Leu Val Pro Leu Lys 
1               5                   10                  15  


<210>  80
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  80

Ile Arg Leu Val Val Ser Arg Leu Gly Leu Asp Ser Leu Cys Pro 
1               5                   10                  15  


<210>  81
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  81

Glu Leu Ser Leu Pro Val Val Gly Ser Gln Leu Val Gly Leu Val 
1               5                   10                  15  


<210>  82
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  82

Gly Val Phe Gly Ala Tyr Phe Asn Val Leu Ile Asn Leu Arg Asp 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  83

Thr Thr Met Arg Arg Leu Ile Pro Pro Phe Arg Glu Ala Ser Ala 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  84

Glu Glu Glu Gln Arg Ile Arg Leu Val Val Ser Arg Leu Gly Leu 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  85

Gly Leu Val Pro Leu Lys Ala Leu Leu Asp Ala Ala Ala Phe Tyr 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  86

Val Leu Ile Asn Leu Arg Asp Ile Thr Asp Glu Ala Phe Lys Asp 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  87

Arg Leu Val Val Ser Arg Leu Gly Leu Asp Ser Leu Cys Pro Phe 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  88

Ser Asn Ile Thr Ile Arg Asn Gln Ile Asn Ala Leu Thr Ser Phe 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  89

Lys Asn Asn Ile Phe Met Ser Asn Ser Tyr Pro Arg Asp Phe Val 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  90

Leu Gly Thr Val Leu Arg Asn Leu Lys Leu Ala Arg Lys Leu Met 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  91

Leu Ile Gln Pro Phe Met Phe Arg Leu Asp Asn Arg Tyr Gln Pro 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  92

Tyr Leu Pro Leu Val Leu Gly Pro Thr Ala Met Arg Lys Tyr Leu 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  93

Leu Gly Thr Val Leu Arg Asn Leu Lys Leu Ala Arg Lys Leu Met 
1               5                   10                  15  


<210>  94
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  94

Gln Glu Ala Arg Lys Ile Val Gly Ala Met Val Gln Ile Ile Thr 
1               5                   10                  15  


<210>  95
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  95

Gln Gln Arg Gln Ala Leu Ala Gln Ile Ser Leu Pro Arg Ile Ile 
1               5                   10                  15  


<210>  96
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  96

Arg Ser Leu Met Phe Met Gln Trp Gly Gln Leu Leu Asp His Asp 
1               5                   10                  15  


<210>  97
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  97

Arg Leu Asp Asn Arg Tyr Gln Pro Met Glu Pro Asn Pro Arg Val 
1               5                   10                  15  


<210>  98
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  98

Glu Leu Leu Ser Tyr Phe Lys Gln Pro Val Ala Ala Thr Arg Thr 
1               5                   10                  15  


<210>  99
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  99

Gln Leu Gly Thr Val Leu Arg Asn Leu Lys Leu Ala Arg Lys Leu 
1               5                   10                  15  


<210>  100
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ala Ile Ile Tyr Leu Ile Leu Leu Phe Thr Ala Val Arg Gly Ile 
1               5                   10                  15      


Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp 
            20                  25                  30          


Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe His 
        35                  40                  45              


Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly 
    50                  55                  60                  


Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala Val 
65                  70                  75                  80  


Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro 
                85                  90                  95      


Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro Val 
            100                 105                 110         


Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe Thr 
        115                 120                 125             


Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val Thr 
    130                 135                 140                 


Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu Phe 
145                 150                 155                 160 


Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val Tyr 
                165                 170                 175     


Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys His 
            180                 185                 190         


Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu Ser Gly 
        195                 200                 205             


Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
    210                 215                 220                 


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys Gly Ser Gly Ser Gly Ser Gly Ser Cys 
        435                 440                 445             


<210>  101
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly Met Leu 
1               5                   10                  15      


Val Ala Ser Ser Leu Gly Gly Asp Leu Ile Ala Glu Val Glu Thr Asp 
            20                  25                  30          


Lys Ala Thr Val Gly Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Ser Gly Asp Thr Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys 
    50                  55                  60                  


His Phe Leu Asn Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile 
65                  70                  75                  80  


Tyr Asn Gln Glu Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr 
                85                  90                  95      


Gln Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser 
            100                 105                 110         


Gln Lys Asp Leu Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys 
        115                 120                 125             


Arg Tyr Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val 
    130                 135                 140                 


Gln Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His 
145                 150                 155                 160 


His Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile 
                165                 170                 175     


Glu Val Arg Trp Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val 
            180                 185                 190         


Ser Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val 
        195                 200                 205             


Met Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val 
    210                 215                 220                 


Glu His Pro Ser Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg 
225                 230                 235                 240 


Ser Glu Ser Ala Gln Ser Lys Ser Gly Gly Gly Gly Gly Asp Lys Thr 
                245                 250                 255     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
            260                 265                 270         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        275                 280                 285             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    290                 295                 300                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
305                 310                 315                 320 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                325                 330                 335     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            340                 345                 350         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        355                 360                 365             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu 
    370                 375                 380                 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys 
385                 390                 395                 400 


Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                405                 410                 415     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            420                 425                 430         


Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  102
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  102

Ile Lys Glu Glu His Val Ile Ile Gln Ala Glu Phe Tyr Leu Asn Pro 
1               5                   10                  15      


Asp Gln Ser Gly Glu Phe Met Phe Asp Phe Asp Gly Asp Glu Ile Phe 
            20                  25                  30          


His Val Asp Met Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe 
        35                  40                  45              


Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly Ala Leu Ala Asn Ile Ala 
    50                  55                  60                  


Val Asp Lys Ala Asn Leu Glu Ile Met Thr Lys Arg Ser Asn Tyr Thr 
65                  70                  75                  80  


Pro Ile Thr Asn Val Pro Pro Glu Val Thr Val Leu Thr Asn Ser Pro 
                85                  90                  95      


Val Glu Leu Arg Glu Pro Asn Val Leu Ile Cys Phe Ile Asp Lys Phe 
            100                 105                 110         


Thr Pro Pro Val Val Asn Val Thr Trp Leu Arg Asn Gly Lys Pro Val 
        115                 120                 125             


Thr Thr Gly Val Ser Glu Thr Val Phe Leu Pro Arg Glu Asp His Leu 
    130                 135                 140                 


Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser Thr Glu Asp Val 
145                 150                 155                 160 


Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu Pro Leu Leu Lys 
                165                 170                 175     


His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu Thr Thr Glu 
            180                 185                 190     


<210>  103
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  103

Gly Asp Thr Gln Pro Arg Phe Leu Glu Gln Ala Lys Cys Glu Cys His 
1               5                   10                  15      


Phe Leu Asn Gly Thr Glu Arg Val Trp Asn Leu Ile Arg Tyr Ile Tyr 
            20                  25                  30          


Asn Gln Glu Glu Tyr Ala Arg Tyr Asn Ser Asp Leu Gly Glu Tyr Gln 
        35                  40                  45              


Ala Val Thr Glu Leu Gly Arg Pro Asp Ala Glu Tyr Trp Asn Ser Gln 
    50                  55                  60                  


Lys Asp Leu Leu Glu Arg Arg Arg Ala Glu Val Asp Thr Tyr Cys Arg 
65                  70                  75                  80  


Tyr Asn Tyr Gly Val Val Glu Ser Phe Thr Val Gln Arg Arg Val Gln 
                85                  90                  95      


Pro Lys Val Thr Val Tyr Pro Ser Lys Thr Gln Pro Leu Gln His His 
            100                 105                 110         


Asn Leu Leu Val Cys Ser Val Asn Gly Phe Tyr Pro Gly Ser Ile Glu 
        115                 120                 125             


Val Arg Trp Phe Arg Asn Ser Gln Glu Glu Lys Ala Gly Val Val Ser 
    130                 135                 140                 


Thr Gly Leu Ile Gln Asn Gly Asp Trp Thr Phe Gln Thr Leu Val Met 
145                 150                 155                 160 


Leu Glu Thr Val Pro Arg Ser Gly Glu Val Tyr Thr Cys Gln Val Glu 
                165                 170                 175     


His Pro Ser Met Met Ser Pro Leu Thr Val Gln Trp Ser Ala Arg Ser 
            180                 185                 190         


Glu Ser Ala Gln Ser Lys 
        195             


<210>  104
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  104

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
65                  70                  75                  80  


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                85                  90                  95      


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105     


<210>  105
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  105

Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Val Ser Lys Leu Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
65                  70                  75                  80  


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                85                  90                  95      


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105     


