                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       Cochran, Jennifer R.
       Kintzing, James R.
       Miller, Caitlyn
 
<120>  Drug Conjugates and Methods of Using Same

<130>  STAN-1624WO

<150>  US  62/851,443
<151>  2019-05-22

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Gly Cys Pro Arg Ile Leu Met Arg Cys Lys Gln Asp Ser Asp Cys Leu 
1               5                   10                  15      


Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys Gly 
            20                  25              


<210>  2
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys Cys 
1               5                   10                  15      


Asp Pro Ala Ala Thr Cys Tyr Cys Arg Phe Phe Asn Ala Phe Cys Tyr 
            20                  25                  30          


Cys Arg 
        


<210>  3
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Cys Gly Glu Thr Cys Val Gly Gly Thr Cys Asn Thr Pro Gly Cys Thr 
1               5                   10                  15      


Cys Ser Trp Pro Val Cys Thr Arg Asn Gly Leu Pro Val 
            20                  25                  


<210>  4
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Ser Gly Ser Asp Gly Gly Val Cys Pro Lys Ile Leu Lys Lys Cys Arg 
1               5                   10                  15      


Arg Asp Ser Asp Cys Pro Gly Ala Cys Ile Cys Arg Gly Asn Gly Tyr 
            20                  25                  30          


Cys Gly 
        


<210>  5
<211>  36
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Met Cys Met Pro Cys Phe Thr Thr Asp His Gln Met Ala Arg Lys Cys 
1               5                   10                  15      


Asp Asp Cys Cys Gly Gly Lys Gly Arg Gly Lys Cys Tyr Gly Pro Gln 
            20                  25                  30          


Cys Leu Cys Arg 
        35      


<210>  6
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Thr Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Ser Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Gly Cys Ala Glu Pro Arg Gly Asp Met Pro Trp Thr Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Gly Cys Val Gly Gly Arg Gly Asp Trp Ser Pro Lys Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Gly Cys Ala Glu Leu Arg Gly Asp Arg Ser Tyr Pro Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gly Cys Arg Leu Pro Arg Gly Asp Val Pro Arg Pro His Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Gly Cys Tyr Pro Leu Arg Gly Asp Asn Pro Tyr Ala Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Gly Cys Thr Ile Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  14
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gly Cys His Pro Pro Arg Gly Asp Asn Pro Pro Val Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  15
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Gly Cys Pro Glu Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  16
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Gly Cys Leu Pro Pro Arg Gly Asp Asn Pro Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Gly Cys His Leu Gly Arg Gly Asp Trp Ala Pro Val Gly Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Gly Cys Asn Val Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Gly Cys Phe Pro Gly Arg Gly Asp Trp Ala Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Gly Cys Pro Leu Pro Arg Gly Asp Asn Pro Pro Thr Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Gly Cys Ser Glu Ala Arg Gly Asp Asn Pro Arg Leu Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  22
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Gly Cys Leu Leu Gly Arg Gly Asp Trp Ala Pro Glu Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  23
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Leu Lys Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  24
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Gly Cys Val Arg Gly Arg Gly Asp Trp Ala Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  25
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Gly Cys Leu Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  26
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Gly Cys Phe Val Gly Arg Gly Asp Trp Ala Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Gly Cys Pro Val Gly Arg Gly Asp Trp Ser Pro Ala Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Gly Cys Pro Arg Pro Arg Gly Asp Asn Pro Pro Leu Thr Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Leu Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Gly Cys Tyr Gln Gly Arg Gly Asp Trp Ser Pro Ser Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Gly Cys Ala Pro Gly Arg Gly Asp Trp Ala Pro Ser Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Gly Cys Val Gln Gly Arg Gly Asp Trp Ser Pro Pro Ser Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  32
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Gly Cys His Val Gly Arg Gly Asp Trp Ala Pro Glu Glu Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  33
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Gly Cys Asp Gly Gly Arg Gly Asp Trp Ala Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Arg Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  34
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Gly Cys Pro Gln Gly Arg Gly Asp Trp Ala Pro Glu Trp Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Pro Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  35
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Gly Cys Pro Arg Gly Arg Gly Asp Trp Ser Pro Pro Ala Cys Lys Gln 
1               5                   10                  15      


Asp Ser Asp Cys Gln Ala Gly Cys Val Cys Gly Pro Asn Gly Phe Cys 
            20                  25                  30          


Gly 
    


<210>  36
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Ser Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Val Cys Tyr Cys Arg 
        35              


<210>  37
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Lys Gly Arg Gly Asp Ala Arg 
            20                  25                  30          


Leu Gln Cys Tyr Cys Arg 
        35              


<210>  38
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Val Gly Arg Gly Asp Asp Asn 
            20                  25                  30          


Leu Lys Cys Tyr Cys Arg 
        35              


<210>  39
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Glu Gly Arg Gly Asp Arg Asp 
            20                  25                  30          


Met Lys Cys Tyr Cys Arg 
        35              


<210>  40
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Gly Cys Val Arg Leu His Glu Ser Cys Leu Gly Gln Gln Val Pro Cys 
1               5                   10                  15      


Cys Asp Pro Ala Ala Thr Cys Tyr Cys Tyr Gly Arg Gly Asp Asn Asp 
            20                  25                  30          


Leu Arg Cys Tyr Cys Arg 
        35              


<210>  41
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  41

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


